Rna encoding an antibody

ABSTRACT

The present invention relates to a RNA encoding an antibody or a fragment or variant thereof and a composition, in particular a passive vaccine, comprising such an RNA. The present invention further relates to the use of such an RNA or of such a composition for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention also relates to a combination of at least two modified RNA&#39;s, in particular wherein one RNA encodes a heavy chain variable region of an antibody and another RNA encodes the corresponding light chain variable region of said antibody.

This application is a national phase application under 35 U.S.C. § 371 of International Application No. PCT/EP2017/060226, filed Apr. 28, 2017, which claims benefit of International Application No. PCT/EP2016/059711, filed Apr. 29, 2016, the entire contents of each of which are hereby incorporated by reference.

The present invention relates to a RNA encoding an antibody or a fragment or variant thereof and a composition, in particular a passive vaccine, comprising such an RNA. The present invention further relates to the use of such an RNA or of such a composition for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention also relates to a combination of at least two modified RNA's, in particular wherein one RNA encodes a heavy chain or a heavy chain variable region of an antibody and another RNA encodes the corresponding light chain or light chain variable region of said antibody.

The occurrence of tumours and cancer diseases is, alongside cardiovascular and infectious diseases, one of the most frequent causes of death in modern societies and is associated with usually considerable costs during the therapy and subsequent rehabilitation measures. The treatment of tumours and cancer diseases depends greatly, for example, on the nature of the tumour which occurs and at present conventionally is undertaken by using radio- or chemotherapy, in addition to invasive interventions. However, these therapies represent an exceptional burden on the immune system, and in some cases can be employed to only a limited extent. Furthermore, these therapy forms usually require long pauses between the individual treatments for regeneration of the immune system. In recent years, alongside these “conventional methods”, molecular biology programmes in particular have emerged as promising for the treatment or for assisting these therapies.

An example of these molecular biology methods comprises the use of antibodies or immunoglobulins as essential effectors of the immune system. Antibodies or immunoglobulins can be generated either in vitro by using known molecular biology methods or by the immune system of the organism itself to be treated. The immune system of higher vertebrates thus has two separate functions of the immune system: the innate immune system, which reacts non-specifically to pathogens (e.g. by macrophage-mediated phagocytosis) and the adaptive immune system, which reacts specifically to pathogens by means of specialized effector cells (e.g. B and T cells). The antibodies or immunoglobulins which are secreted by plasma cells during an immune response are part of this adaptive immune system. Together with the complement system, they form the humoral branch of the immune response.

Alongside their essential importance for the immune system in higher vertebrates, precisely because of their high affinity and specificity for a particular antigen antibodies are an outstanding means both in biochemical and molecular biology research and in diagnostics and medical uses. Thus, antibodies are capable of binding specifically to their target structures (e.g. antigens, which substantially comprise proteins, peptides, in some cases lipids, carbohydrates etc.) and of thereby blocking (inhibiting) or, where appropriate, labelling these. They can moreover activate the immune system by means of their Fc part, so that the labelled cells are destroyed. Over 100 therapeutic antibodies are currently to be found in clinical studies. Antibodies which can be employed in cancer therapy play by far the most important role in this context. Most of the antibodies prepared for this at present are monoclonal antibodies which originate originally, for example, from the mouse. In order to prevent an immune reaction against such monoclonal antibodies, at present chiefly humanized or human antibodies are employed for therapy (cf. David Male; “Immunologie auf einen Blick [Immunology at a Glance]”, 1st German edition, 2005, Elsevier-Urban & Fischer Verlag; Charles A. Janeway, Paul Travers, Mark Walport and Mark Shlomchik, Immunobiology, 5th edition, 2001, Garland Publishing; Dissertation by Christian Klein, Monoklonale Antikörper and rekombinante Antikörperfragmente gegen sekundäre Arzneipflanzenmetabolite [Monoclonal Antibodies and Recombinant Antibody Fragments Against Secondary Medicinal Plant Metabolites], 2004; Andreas Schmiedl and Stefan Dübel, Rekombinante Antikörper & Phagen-Display [Recombinant Antibody & Phage Display], 2004, Molekulare Biotechnologie [Molecular Biotechnology] (Wiley-VCH)).

Antibodies are typically immunoglobulins or can be derived from immunoglobulins. Immunoglobulins can in turn be differentiated into five main classes of immunoglobulins on the basis of their heavy chain, the IgM (μ), IgD (δ), IgG (γ), IgA (α) and IgE (ε) antibodies, IgG antibodies making up the largest proportion. Immunoglobulins can moreover be differentiated into the isotypes κ and λ on the basis of their light chains.

For example, IgG antibodies are typically built up two identical light and two heavy protein chains which are bonded to one another via disulfide bridges. As shown in FIG. 1, the light chain comprises the N-terminal variable domain V_(L) (also referred to as “light chain variable region”) and the C-terminal constant domain C_(L) (also referred to as “light chain constant region”). The heavy chain of an IgG antibody can be divided into an N-terminal variable domain V_(H) (also referred to as “heavy chain variable region”) and three constant domains C_(H)1, C_(H)2 and C_(H)3 (all three constant domains together are also referred to as “heavy chain constant region”). While the amino acid sequence is largely the same in the region of the constant domains, wide differences in sequence are typically found within the variable domains.

The antibody repertoire of a human comprises about at least 10¹¹ different antibody specificities. In higher vertebrates, the formation of antibodies takes place naturally in the immune system by somatic recombination. In this context, an organism is indeed theoretically capable of generating an antibody of appropriate specificity against any antigen. However, if each of these antibodies were to be coded by an endogenous gene, they would burst the human genome. Instead, in humans antibody genes are composed of a large number of individual gene segments. The part of the antibody gene which codes for the variable region of a light chain is formed from a V gene segment and a J gene segment. In this context, numerous different V and J segments are available, which can be combined with one another virtually as desired. In this context, the variable region of a heavy chain is composed of three different gene segments. In addition to the V and J segments, additional D segments are also found here. The V_(H), D_(H) and J_(H) segments can likewise be combined with one another virtually as desired to form the variable region of the heavy chain (cf. FIG. 2). The mechanism by which the various gene segments are combined to form complete antibody genes is called immunoglobulin rearrangement or somatic recombination. It takes place exclusively in B lymphocytes at certain times of cell development.

In addition to pure gene rearrangement, further mechanisms for increasing the antibody diversity also exist. Two mechanisms which are accompanied by somatic recombination are first to be mentioned in this context: The junctional diversity in this context describes controlled imprecise joining together of the rearranged gene segments, as a result of which random removal and insertion of nucleotides occurs at the cleavage sites. A further combinatorial diversity results from the possibility of combining a particular rearranged light chain with a particular rearranged heavy chain. Finally, the diversity of antibodies is also additionally increased after successful rearrangement and later activation of B cells, in that an affinity maturation of antibodies occurs due to an increased rate of mutation in the region of the variable regions of activated B cells (somatic hypermutation).

In addition to the formation of antibodies which takes place naturally by the immune system of the particular organism, antibodies can also be generated by molecular biology methods. However, in order to utilize the system elaborated for specification of antibody formation and specification thereof for particular antigens or nucleic acids, the formation of antibodies is at present typically induced in selected organisms by injection of a particular antigen, and the antibody is then isolated from the organism for further use. In this context, the B lymphocytes of the organism are conventionally purified selectively and fused with an immortal myeloma cell to form a hybridoma cell. Those cells which secrete the corresponding antigen-specific antibodies are then determined by selection methods.

In addition to use of hybridoma cells, recombinant preparation of these antibodies with the desired specificity is also possible after isolation and sequencing. Cells which provide the required posttranslational modifications are typically used for this. On the basis of the immune reaction with formation of human anti-mouse antibodies in the human organism in the case of native antibodies produced in the mouse (or in other hosts), chimeric, humanized or human antibodies are preferably prepared here.

After expression, these antibodies, optionally prepared by recombinant methods, can be employed as agents both in biochemical and molecular biology research, and in diagnostics and for medical uses.

In medical uses, however, in many cases antibodies can be employed directly only with difficulty, since these usually have only a very short half-life in vivo and therefore, possibly, cannot reach their target antigen or their target nucleic acid at all. This requires either high active compound concentrations of the desired antibody, or alternative methods which are suitable for providing large amounts of antibodies in vivo.

Such methods include, e.g. molecular medicine methods of gene therapy and genetic vaccination which, when used generally in the therapy and prevention of diseases, have considerable effects on medical practice. Both methods are based on the introduction of nucleic acids into cells or into tissue of the patient and on subsequent processing by the cells or, respectively, tissue of the information coded by the nucleic acids introduced, i.e. expression of the desired polypeptides, e.g. antibodies, in the cells or respectively, the tissue.

The conventional procedure of methods of gene therapy and of genetic vaccination is based on the use of DNA to sluice the required genetic information into the cell. Various methods for introducing DNA into cells have been developed in this connection, such as, for example, calcium phosphate transfection, polyprene transfection, protoplast fusion, electroporation, microinjection, lipofection and the use of gene canons, lipofection in particular having emerged as a suitable method.

A further method which has been proposed in particular in the case of genetic vaccination methods is the use of DNA viruses as DNA vehicles. Such viruses have the advantage that because of their infectious properties a very high transfection rate can be achieved. The viruses used are genetically modified, so that no functional infectious particles are formed in the transfected cell. The use of DNA viruses as DNA vehicles, however, has been criticized in recent years because of the risk of recombination of non-active viruses to give active viruses.

The use of DNA as an agent in gene therapy and genetic vaccination or for passive immunization (by passive vaccines), e.g. by using coding sequences for antibodies, may, however, also be less advantageous from some points of view. DNA is degraded only relatively slowly in the bloodstream, so that when (foreign) DNA is used as the coding sequence for a desired protein, a formation of anti-DNA antibodies may occur, which has been confirmed in an animal model in the mouse (Gilkeson et al., J. Clin. Invest. 1995, 95: 1398-1402). The possible persistence of (foreign) DNA in the organism can thus lead to a hyperactivation of the immune system, which as is known results in splenomegaly in mice (Montheith et al., Anticancer Drug Res. 1997, 12(5): 421-432). Furthermore, (foreign) DNA can interact with the host genome, and in particular cause mutations by integration into the host genome. Thus, for example, the (foreign) DNA introduced may be inserted into an intact gene, which represents a mutation which can impede or even completely switch off the function of the endogenous gene. On the one hand enzyme systems which are vital for the cell may be destroyed by such integration events, and on the other hand there is also the danger of a transformation of the cell modified in this way into a degenerated state if a gene which is decisive for regulation of cell growth is modified by the integration of the foreign DNA. With the methods to date of gene therapy and genetic vaccination and also of passive immunization, a risk of development of cancer therefore cannot necessarily be ruled out when (foreign) DNA is used. In this context, passive immunization (by so-called “passive vaccines”) is to be strictly differentiated from so-called active immunization. In active immunization, an antigen (“active vaccine”) is typically administered, after which the organism forms antibodies against this antigen. Active immunization thus creates a permanent immunization of the organism against the particular antigen, which can be associated with the disadvantages described above. In passive immunization, in contrast, only an antiserum or the purified antibody itself (“passive vaccine”) is administered to the organism. The coding sequence for the antibody can likewise be administered, as described above, as a so-called passive vaccine for passive immunization.

Summarizing, in the prior art there is an increased demand for and a considerable interest in agents which are suitable for employing antibodies effectively in vivo, in particular for providing increased active compound amounts of antibodies in vivo, without the risks hitherto associated with the use of DNA.

It is thus an object of the present invention to provide an RNA encoding an antibody or a fragment thereof. In particular, it is an object to provide a system for expressing an antibody. It is a further object of the invention to provide such a system, which allows treatment and/or prophylaxis of a variety of diseases with antibodies in a safe and effective manner. It is thus a particular object of the present invention to provide a composition, in particular a passive vaccine, for treatment or prophylaxis of a variety of diseases, such as cancer, cardiovascular diseases, infectious diseases, autoimmune diseases, virus diseases and monogenetic diseases.

The object underlying the present invention is solved by the claimed subject matter.

The present application is filed together with a sequence listing in electronic format. The sequence listing is provided as a file entitled CU01P215WO1_Sequence listing.txt, created on Apr. 26, 2017, which is 50,982 KB in size. The information contained in the electronic format of the sequence listing is incorporated herein by reference in its entirety.

For the sake of clarity and readability the following definitions are provided. Any technical feature mentioned for these definitions may be read on each and every embodiment of the invention. Additional definitions and explanations may be specifically provided in the context of these embodiments.

Adaptive immune response: The adaptive immune response is typically understood to be an antigen-specific response of the immune system. Antigen specificity allows for the generation of responses that are tailored, for example, to specific pathogens or pathogen-infected cells. The ability to mount these tailored responses is usually maintained in the body by “memory cells”. Should a pathogen infect the body more than once, these specific memory cells are used to quickly eliminate it. In this context, the first step of an adaptive immune response is the activation of naïve antigen-specific T cells or different immune cells able to induce an antigen-specific immune response by antigen-presenting cells. This occurs in the lymphoid tissues and organs through which naïve T cells are constantly passing. The three cell types that may serve as antigen-presenting cells are dendritic cells, macrophages, and B cells. Each of these cells has a distinct function in eliciting immune responses. Dendritic cells may take up antigens by phagocytosis and macropinocytosis and may become stimulated by contact with e.g. a foreign antigen to migrate to the local lymphoid tissue, where they differentiate into mature dendritic cells. Macrophages ingest particulate antigens such as bacteria and are induced by infectious agents or other appropriate stimuli to express MHC molecules. The unique ability of B cells to bind and internalize soluble protein antigens via their receptors may also be important to induce T cells. MHC-molecules are, typically, responsible for presentation of an antigen to T-cells. Therein, presenting the antigen on MHC molecules leads to activation of T cells, which induces their proliferation and differentiation into armed effector T cells. The most important function of effector T cells is the killing of infected cells by CD8+ cytotoxic T cells and the activation of macrophages by Th1 cells, which together make up cell-mediated immunity, and the activation of B cells by both Th2 and Th1 cells to produce different classes of antibody, thus driving the humoral immune response. T cells recognize an antigen by their T cell receptors which do not recognize and bind the antigen directly, but instead recognize short peptide fragments e.g. of pathogen-derived protein antigens, e.g. so-called epitopes, which are bound to MHC molecules on the surfaces of other cells.

Adaptive immune system: The adaptive immune system is essentially dedicated to eliminate or prevent pathogenic growth. It typically regulates the adaptive immune response by providing the vertebrate immune system with the ability to recognize and remember specific pathogens (to generate immunity), and to mount stronger attacks each time the pathogen is encountered. The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all of the progeny (offspring) of such a cell will then inherit genes encoding the same receptor specificity, including the Memory B cells and Memory T cells that are the keys to long-lived specific immunity.

Adjuvant/adjuvant component: An adjuvant or an adjuvant component in the broadest sense is typically a pharmacological and/or immunological agent that may modify, e.g. enhance, the effect of other agents, such as a drug or vaccine. It is to be interpreted in a broad sense and refers to a broad spectrum of substances. Typically, these substances are able to increase the immunogenicity of antigens. For example, adjuvants may be recognized by the innate immune systems and, e.g., may elicit an innate immune response. “Adjuvants” typically do not elicit an adaptive immune response. Insofar, “adjuvants” do not qualify as antigens. Their mode of action is distinct from the effects triggered by antigens resulting in an adaptive immune response.

Antibody: As used herein, the term “antibody” encompasses various forms of antibodies, preferably monoclonal antibodies, including but not being limited to whole antibodies, antibodies of any (recombinant or naturally occurring) antibody format, human antibodies, chimeric antibodies, humanized antibodies and genetically engineered antibodies (variant or mutant antibodies) as long as the characteristic properties of an antibody are retained. Namely, an antibody recognizes a unique molecule of an antigen via its variable region. In particular, the antibody mediates this function by binding to the antigen. In particular, the term “antibody” refers to both, glycosylated and non-glycosylated immunoglobulins of any isotype or subclass (preferably IgG). An antibody may also be derived from an immunoglobulin, however, an antibody typically comprises an antigen-binding region (of an immunoglobulin) that is in particular able to compete with the “intact” immunoglobulin antibody for specific binding, unless otherwise specified. Preferred examples of antibodies include monoclonal antibodies, bispecific antibodies, minibodies, domain antibodies, synthetic antibodies, antibody mimetics, chimeric antibodies, humanized antibodies, human antibodies, antibody fusions, antibody conjugates, single chain antibodies, antibody derivatives, and antibody analogues. Unless otherwise indicated, the term “antibody” includes, in addition to antibodies comprising two full-length heavy chains and two full-length light chains, derivatives, variants, and antibodies of any formats, which do not comprise two full-length heavy chains and two full-length light chains. In some instances an “antibody” may thus include fewer chains, for example a single chain only. Especially preferred are human or humanized monoclonal antibodies and/or recombinant antibodies, especially as recombinant human monoclonal antibodies. Particularly preferred are human IgG-type antibodies.

Human antibody: The term “human antibody”, as used herein, is intended to include antibodies having variable and constant regions derived from human (germ line) immunoglobulin sequences. In other words, the term “human antibodies” refers to antibodies which have human sequences, that is to say in the constant regions (if present) and in the variable regions. Human antibodies are well-known in the state of the art (van Dijk, M. A., and van de Winkel, J. G., Curr. Opin. Chem. Biol. 5 (2001) 368-374). Human antibodies can also be produced in transgenic animals (e.g., mice) that are capable, upon immunization, of producing a full repertoire or a selection of human antibodies in the absence of endogenous immunoglobulin production. Transfer of the human germ-line immunoglobulin gene array in such germ-line mutant mice will result in the production of human antibodies upon antigen challenge (see, e.g., Jakobovits, A., et al., Proc. Natl. Acad. Sci. USA 90 (1993) 2551-2555; Jakobovits, A., et al., Nature 362 (1993) 255-258; Bruggemann, M., et al., Year Immunol. 7 (1993) 3340). Human antibodies can also be produced in phage display libraries (Hoogenboom, H. R., and Winter, G., J. Mol. Biol. 227 (1992) 381-388; Marks, J. D., et al., J. Mol. Biol. 222 (1991) 581-597). The techniques of Cole et al. and Boerner et al. are also available for the preparation of human monoclonal antibodies (Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77 (1985); and Boerner, P., et al., J. Immunol. 147 (1991) 86-95). In particular, the term “human antibody” as used herein also comprises antibodies of recombinant antibody formats as long as the variable regions (including the hypervariable regions) have human (germ line) immunoglobulin sequences.

Antigen: In the context of the present invention, the term “antigen” typically refers to a substance, which is capable of being recognized by the immune system, preferably by the adaptive immune system, and which is capable of eliciting an antigen-specific immune response, e.g. by formation of antibodies and/or antigen-specific T cells as part of an adaptive immune response. Typically, an antigen may be or may comprise a peptide or protein, which may be presented by the MHC to T-cells. In the sense of the present invention an antigen may be the product of translation of a provided nucleic acid molecule, preferably an RNA comprising at least one coding sequence as defined herein. In this context, also fragments, variants and derivatives of an antigen, such as a peptide or a protein, comprising at least one epitope are understood as antigens.

Artificial nucleic acid molecule: An artificial nucleic acid molecule may typically be understood to be a nucleic acid molecule, e.g. a DNA or an RNA, that does not occur naturally. In other words, an artificial nucleic acid molecule may be understood as a non-natural nucleic acid molecule. Such nucleic acid molecule may be non-natural due to its individual sequence (which does not occur naturally) and/or due to other modifications, e.g. structural modifications of nucleotides, which do not occur naturally. An artificial nucleic acid molecule may be a DNA molecule, an RNA molecule or a hybrid-molecule comprising DNA and RNA portions. Typically, artificial nucleic acid molecules may be designed and/or generated by genetic engineering methods to correspond to a desired artificial sequence of nucleotides (heterologous sequence). In this context an artificial sequence is usually a sequence that may not occur naturally, i.e. it differs from the wild type sequence by at least one nucleotide. The term “wild type” may be understood as a sequence occurring in nature. Further, the term “artificial nucleic acid molecule” is not restricted to mean “one single molecule” but is, typically, understood to comprise an ensemble of identical molecules. Accordingly, it may relate to a plurality of identical molecules contained in an aliquot.

Bicistronic RNA, multicistronic RNA: A bicistronic or multicistronic RNA is typically an RNA, preferably an mRNA, that typically may have two (bicistronic) or more (multicistronic) open reading frames (ORF). An open reading frame in this context is a sequence of codons that is translatable into a peptide or protein.

Carrier/polymeric carrier: A carrier in the context of the invention may typically be a compound that facilitates transport and/or complexation of another compound (cargo). A polymeric carrier is typically a carrier that is formed of a polymer. A carrier may be associated to its cargo by covalent or non-covalent interaction. A carrier may transport nucleic acids, e.g. RNA or DNA, to the target cells. The carrier may—for some embodiments—be a cationic component.

Cationic component: The term “cationic component” typically refers to a charged molecule, which is positively charged (cation) at a pH value typically from 1 to 9, preferably at a pH value of or below 9 (e.g. from 5 to 9), of or below 8 (e.g. from 5 to 8), of or below 7 (e.g. from 5 to 7), most preferably at a physiological pH, e.g. from 7.3 to 7.4. Accordingly, a cationic component may be any positively charged compound or polymer, preferably a cationic peptide or protein, which is positively charged under physiological conditions, particularly under physiological conditions in vivo. A “cationic peptide or protein” may contain at least one positively charged amino acid, or more than one positively charged amino acid, e.g. selected from Arg, His, Lys or Orn. Accordingly, “polycationic” components are also within the scope exhibiting more than one positive charge under the conditions given.

5′-cap: A 5′-cap is an entity, typically a modified nucleotide entity, which generally “caps” the 5′-end of a mature mRNA. A 5′-cap may typically be formed by a modified nucleotide, particularly by a derivative of a guanine nucleotide. Preferably, the 5′-cap is linked to the 5′-terminus via a 5′-5′-triphosphate linkage. A 5′-cap may be methylated, e.g. m7GpppN, wherein N is the terminal 5′ nucleotide of the nucleic acid carrying the 5′-cap, typically the 5′-end of an RNA. Further examples of 5′cap structures include glyceryl, inverted deoxy abasic residue (moiety), 4′,5′ methylene nucleotide, 1-(beta-D-erythrofuranosyl) nucleotide, 4′-thio nucleotide, carbocyclic nucleotide, 1,5-anhydrohexitol nucleotide, L-nucleotides, alpha-nucleotide, modified base nucleotide, threo-pentofuranosyl nucleotide, acyclic 3′,4′-seco nucleotide, acyclic 3,4-dihydroxybutyl nucleotide, acyclic 3,5 dihydroxypentyl nucleotide, 3′-3′-inverted nucleotide moiety, 3′-3′-inverted abasic moiety, 3′-2′-inverted nucleotide moiety, 3′-2′-inverted abasic moiety, 1,4-butanediol phosphate, 3′-phosphoramidate, hexylphosphate, aminohexyl phosphate, 3′-phosphate, 3′phosphorothioate, phosphorodithioate, or bridging or non-bridging methylphosphonate moiety.

Cellular immunity/cellular immune response: Cellular immunity relates typically to the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In more general terms, cellular immunity is not based on antibodies, but on the activation of cells of the immune system. Typically, a cellular immune response may be characterized e.g. by activating antigen-specific cytotoxic T-lymphocytes that are able to induce apoptosis in cells, e.g. specific immune cells like dendritic cells or other cells, displaying epitopes of foreign antigens on their surface. Such cells may be virus-infected or infected with intracellular bacteria, or cancer cells displaying antibodies. Further characteristics may be activation of macrophages and natural killer cells, enabling them to destroy pathogens and stimulation of cells to secrete a variety of cytokines that influence the function of other cells involved in adaptive immune responses and innate immune responses.

DNA: DNA is the usual abbreviation for deoxy-ribonucleic acid. It is a nucleic acid molecule, i.e. a polymer consisting of nucleotides. These nucleotides are usually deoxy-adenosine-monophosphate, deoxy-thymidine-monophosphate, deoxy-guanosine-monophosphate and deoxy-cytidine-monophosphate monomers which are—by themselves—composed of a sugar moiety (deoxyribose), a base moiety and a phosphate moiety, and polymerise by a characteristic backbone structure. The backbone structure is, typically, formed by phosphodiester bonds between the sugar moiety of the nucleotide, i.e. deoxyribose, of a first and a phosphate moiety of a second, adjacent monomer. The specific order of the monomers, i.e. the order of the bases linked to the sugar/phosphate-backbone, is called the DNA sequence. DNA may be single stranded or double stranded. In the double stranded form, the nucleotides of the first strand typically hybridize with the nucleotides of the second strand, e.g. by KT-base-pairing and G/C-base-pairing.

Epitope: In the context of the present invention, the term ‘epitope’ typically refers to a fragment of an antigen or a variant of an antigen, wherein said fragment is presented by an MHC complex. Such a fragment comprising or consisting of an epitope as used herein may typically comprise from about 5 to about 20 amino acids. An epitope may also be referred to herein as ‘antigen determinant’. Epitopes can be distinguished in T cell epitopes and B cell epitopes. T cell epitopes or parts of the proteins in the context of the present invention may comprise fragments preferably having a length of about 6 to about 20 or even more amino acids, e.g. fragments as processed and presented by MHC class I molecules, preferably having a length of about 8 to about 10 amino acids, e.g. 8, 9, or 10, (or even 11, or 12 amino acids), or fragments as processed and presented by MHC class II molecules, preferably having a length of about 13 or more amino acids, e.g. 13, 14, 15, 16, 17, 18, 19, 20 or even more amino acids, wherein these fragments may be selected from any part of the amino acid sequence. These fragments are typically recognized by T cells in form of a complex consisting of the peptide fragment and an MHC molecule, i.e. the fragments are typically not recognized in their native form. B cell epitopes are typically fragments located on the outer surface of (native) protein or peptide antigens as defined herein, preferably having 5 to 15 amino acids, more preferably having 5 to 12 amino acids, even more preferably having 6 to 9 amino acids, which may be recognized by antibodies, i.e. in their native form. Such epitopes of proteins or peptides may furthermore be selected from any of the herein mentioned variants of such proteins or peptides. In this context, antigenic determinants can be conformational or discontinuous epitopes, which are composed of segments of the proteins or peptides as defined herein that are discontinuous in the amino acid sequence of the proteins or peptides as defined herein but are brought together in the three-dimensional structure or continuous or linear epitopes, which are composed of a single polypeptide chain.

Fragment of a sequence: A fragment of a sequence may typically be a shorter portion of a full-length sequence of e.g. a nucleic acid molecule or an amino acid sequence. Accordingly, a fragment, typically, consists of a sequence that is identical to the corresponding stretch within the full-length sequence. A preferred fragment of a sequence in the context of the present invention, consists of a continuous stretch of entities, such as nucleotides or amino acids corresponding to a continuous stretch of entities in the molecule the fragment is derived from, which represents at least 20%, preferably at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, and most preferably at least 80% of the total (i.e. full-length) molecule from which the fragment is derived.

G/C modified: A G/C-modified nucleic acid may typically be a nucleic acid, preferably an artificial nucleic acid molecule as defined herein, based on a modified wild-type sequence comprising a preferably increased number of guanosine and/or cytosine nucleotides as compared to the wild-type sequence. Such an increased number may be generated by substitution of codons containing adenosine or thymidine nucleotides by codons containing guanosine or cytosine nucleotides. If the enriched G/C content occurs in a coding region of DNA or RNA, it makes use of the degeneracy of the genetic code. Accordingly, the codon substitutions preferably do not alter the encoded amino acid residues, but exclusively increase the G/C content of the nucleic acid molecule. As used herein, the term ‘G/C modification’ comprises, in particular, the modifications of the number of guanosine and/or cytosine nucleotides in the RNA according to the invention, such as GC optimization of sequences, adaptation of sequences to human codon usage, codon optimization or C-optimization of sequences.

Gene therapy: Gene therapy may typically be understood to mean a treatment of a patient's body or isolated elements of a patient's body, for example isolated tissues/cells, by nucleic acids encoding a peptide or protein. It typically may comprise at least one of the steps of a) administration of a nucleic acid, preferably an RNA as defined herein, directly to the patient—by whatever administration route—or in vitro to isolated cells/tissues of the patient, which results in transfection of the patient's cells either in vivo/ex vivo or in vitro; b) transcription and/or translation of the introduced nucleic acid molecule; and optionally c) re-administration of isolated, transfected cells to the patient, if the nucleic acid has not been administered directly to the patient.

Genetic vaccination: Genetic vaccination may typically be understood to be vaccination by administration of a nucleic acid molecule encoding an antigen or an immunogen or fragments thereof. The nucleic acid molecule may be administered to a subject's body or to isolated cells of a subject. Upon transfection of certain cells of the body or upon transfection of the isolated cells, the antigen or immunogen may be expressed by those cells and subsequently presented to the immune system, eliciting an adaptive, i.e. antigen-specific immune response. Accordingly, genetic vaccination typically comprises at least one of the steps of a) administration of a nucleic acid, preferably an artificial nucleic acid molecule as defined herein, to a subject, preferably a patient, or to isolated cells of a subject, preferably a patient, which usually results in transfection of the subject's cells either in vivo or in vitro; b) transcription and/or translation of the introduced nucleic acid molecule; and optionally c) re-administration of isolated, transfected cells to the subject, preferably the patient, if the nucleic acid has not been administered directly to the patient.

Heterologous sequence: Two sequences are typically understood to be ‘heterologous’ if they are not derivable from the same gene. I.e., although heterologous sequences may be derivable from the same organism, they naturally (in nature) do not occur in the same nucleic acid molecule, such as in the same mRNA.

Humoral immunity/humoral immune response: Humoral immunity refers typically to antibody production and optionally to accessory processes accompanying antibody production. A humoral immune response may be typically characterized, e.g., by Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation. Humoral immunity also typically may refer to the effector functions of antibodies, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination.

Immunogen: In the context of the present invention, an immunogen may be typically understood to be a compound that is able to stimulate an immune response. Preferably, an immunogen is a peptide, polypeptide, or protein. In a particularly preferred embodiment, an immunogen in the sense of the present invention is the product of translation of a provided nucleic acid molecule, preferably an artificial nucleic acid molecule as defined herein. Typically, an immunogen elicits at least an adaptive immune response.

Immunostimulatory composition: In the context of the invention, an immunostimulatory composition may be typically understood to be a composition containing at least one component which is able to induce an immune response or from which a component, which is able to induce an immune response, is derivable. Such immune response may be preferably an innate immune response or a combination of an adaptive and an innate immune response. Preferably, an immunostimulatory composition in the context of the invention contains at least one artificial nucleic acid molecule, more preferably an RNA, for example an mRNA molecule. The immunostimulatory component, such as the mRNA may be complexed with a suitable carrier. Thus, the immunostimulatory composition may comprise an mRNA/carrier-complex. Furthermore, the immunostimulatory composition may comprise an adjuvant and/or a suitable vehicle for the immunostimulatory component, such as the mRNA.

Immune response: An immune response may typically be a specific reaction of the adaptive immune system to a particular antigen (so called specific or adaptive immune response) or an unspecific reaction of the innate immune system (so called unspecific or innate immune response), or a combination thereof.

Immune system: The immune system may protect organisms from infection. If a pathogen succeeds in passing a physical barrier of an organism and enters this organism, the innate immune system provides an immediate, but non-specific response. If pathogens evade this innate response, vertebrates possess a second layer of protection, the adaptive immune system. Here, the immune system adapts its response during an infection to improve its recognition of the pathogen. This improved response is then retained after the pathogen has been eliminated, in the form of an immunological memory, and allows the adaptive immune system to mount faster and stronger attacks each time this pathogen is encountered. According to this, the immune system comprises the innate and the adaptive immune system. Each of these two parts typically contains so called humoral and cellular components.

Immunostimulatory RNA: An immunostimulatory RNA (isRNA) in the context of the invention may typically be an RNA that is able to induce an innate immune response. It usually does not have an open reading frame and thus does not provide a peptide-antigen or immunogen but elicits an immune response e.g. by binding to a specific kind of Toll-like-receptor (TLR) or other suitable receptors. However, of course also mRNAs having an open reading frame and coding for a peptide/protein may induce an innate immune response and, thus, may be immunostimulatory RNAs.

Innate immune system: The innate immune system, also known as non-specific (or unspecific) immune system, typically comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner. This means that the cells of the innate system may recognize and respond to pathogens in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. The innate immune system may be, e.g., activated by ligands of Toll-like receptors (TLRs) or other auxiliary substances such as lipopolysaccharides, TNF-alpha, CD40 ligand, or cytokines, monokines, lymphokines, interleukins or chemokines, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, IL-29, IL-30, IL-31, IL-32, IL-33, IFN-alpha, IFN-beta, IFN-gamma, GM-CSF, G-CSF, M-CSF, LT-beta, TNF-alpha, growth factors, and hGH, a ligand of human Toll-like receptor TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, a ligand of murine Toll-like receptor TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12 or TLR13, a ligand of a NOD-like receptor, a ligand of a RIG-I like receptor, an immunostimulatory nucleic acid, an immunostimulatory RNA (isRNA), a CpG-DNA, an antibacterial agent, or an anti-viral agent. The pharmaceutical composition according to the present invention may comprise one or more such substances. Typically, a response of the innate immune system includes recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines; activation of the complement cascade; identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialized white blood cells; activation of the adaptive immune system; and/or acting as a physical and chemical barrier to infectious agents.

Cloning site: A cloning site is typically understood to be a segment of a nucleic acid molecule, which is suitable for insertion of a nucleic acid sequence, e.g., a nucleic acid sequence comprising an open reading frame. Insertion may be performed by any molecular biological method known to the one skilled in the art, e.g. by restriction and ligation. A cloning site typically comprises one or more restriction enzyme recognition sites (restriction sites). These one or more restrictions sites may be recognized by restriction enzymes which cleave the DNA at these sites. A cloning site which comprises more than one restriction site may also be termed a multiple cloning site (MCS) or a polylinker.

Nucleic acid molecule: A nucleic acid molecule is a molecule comprising, preferably consisting of nucleic acid components. The term nucleic acid molecule preferably refers to DNA or RNA molecules. It is preferably used synonymous with the term “polynucleotide”. Preferably, a nucleic acid molecule is a polymer comprising or consisting of nucleotide monomers, which are covalently linked to each other by phosphodiester-bonds of a sugar/phosphate-backbone. The term “nucleic acid molecule” also encompasses modified nucleic acid molecules, such as base-modified, sugar-modified or backbone-modified etc. DNA or RNA molecules.

Open reading frame: An open reading frame (ORF) in the context of the invention may typically be a sequence of several nucleotide triplets, which may be translated into a peptide or protein. An open reading frame preferably contains a start codon, i.e. a combination of three subsequent nucleotides coding usually for the amino acid methionine (ATG), at its 5′-end and a subsequent region, which usually exhibits a length which is a multiple of 3 nucleotides. An ORF is preferably terminated by a stop-codon (e.g., TAA, TAG, TGA). Typically, this is the only stop-codon of the open reading frame. Thus, an open reading frame in the context of the present invention is preferably a nucleotide sequence, consisting of a number of nucleotides that may be divided by three, which starts with a start codon (e.g. ATG) and which preferably terminates with a stop codon (e.g., TAA, TGA, or TAG). The open reading frame may be isolated or it may be incorporated in a longer nucleic acid sequence, for example in a vector or an mRNA. An open reading frame may also be termed “(protein) coding region” or, preferably, “coding sequence”.

Peptide: A peptide or polypeptide is typically a polymer of amino acid monomers, linked by peptide bonds. It typically contains less than 50 monomer units. Nevertheless, the term peptide is not a disclaimer for molecules having more than 50 monomer units. Long peptides are also called polypeptides, typically having between 50 and 600 monomeric units.

Pharmaceutically effective amount: A pharmaceutically effective amount in the context of the invention is typically understood to be an amount that is sufficient to induce a pharmaceutical effect, such as an immune response, altering a pathological level of an expressed peptide or protein, or substituting a lacking gene product, e.g., in case of a pathological situation.

Protein: A protein typically comprises one or more peptides or polypeptides. A protein is typically folded into 3-dimensional form, which may be required for the protein to exert its biological function.

Poly(A) sequence: A poly(A) sequence, also called poly(A) tail or 3′-poly(A) tail, is typically understood to be a sequence of adenosine nucleotides, e.g., of up to about 400 adenosine nucleotides, e.g. from about 5 to about 400, preferably from about 10 to about 200, more preferably from about 10 to about 100, even more preferably from about 40 to about 80, most preferably from about 50 to about 70 adenosine nucleotides. A poly(A) sequence is typically located at the 3′end of an mRNA. In the context of the present invention, a poly(A) sequence may be located within an mRNA or any other nucleic acid molecule, such as, e.g., in a vector, for example, in a vector serving as template for the generation of an RNA, preferably an mRNA, e.g., by transcription of the vector.

Polyadenylation: Polyadenylation is typically understood to be the addition of a poly(A) sequence to a nucleic acid molecule, such as an RNA molecule, e.g. to a premature mRNA. Polyadenylation may be induced by a so-called polyadenylation signal. This signal is preferably located within a stretch of nucleotides at the 3′-end of a nucleic acid molecule, such as an RNA molecule, to be polyadenylated. A polyadenylation signal typically comprises a hexamer consisting of adenine and uracil/thymine nucleotides, preferably the hexamer sequence AAUAAA. Other sequences, preferably hexamer sequences, are also conceivable. Polyadenylation typically occurs during processing of a pre-mRNA (also called premature-mRNA). Typically, RNA maturation (from pre-mRNA to mature mRNA) comprises the step of polyadenylation.

Restriction site: A restriction site, also termed restriction enzyme recognition site, is a nucleotide sequence recognized by a restriction enzyme. A restriction site is typically a short, preferably palindromic nucleotide sequence, e.g. a sequence comprising 4 to 8 nucleotides. A restriction site is preferably specifically recognized by a restriction enzyme. The restriction enzyme typically cleaves a nucleotide sequence comprising a restriction site at this site. In a double-stranded nucleotide sequence, such as a double-stranded DNA sequence, the restriction enzyme typically cuts both strands of the nucleotide sequence.

RNA, mRNA: RNA is the usual abbreviation for ribonucleic-acid. It is a nucleic acid molecule, i.e. a polymer consisting of nucleotides. These nucleotides are usually adenosine-monophosphate, uridine-monophosphate, guanosine-monophosphate and cytidine-monophosphate monomers which are connected to each other along a so-called backbone. The backbone is formed by phosphodiester bonds between the sugar, i.e. ribose, of a first and a phosphate moiety of a second, adjacent monomer. The specific succession of the monomers is called the RNA-sequence. Usually RNA may be obtainable by transcription of a DNA-sequence, e.g., inside a cell. In eukaryotic cells, transcription is typically performed inside the nucleus or the mitochondria. In vivo, transcription of DNA usually results in the so-called premature RNA which has to be processed into so-called messenger-RNA, usually abbreviated as mRNA. Processing of the premature RNA, e.g. in eukaryotic organisms, comprises a variety of different posttranscriptional-modifications such as splicing, 5′-capping, polyadenylation, export from the nucleus or the mitochondria and the like. The sum of these processes is also called maturation of RNA. The mature messenger RNA usually provides the nucleotide sequence that may be translated into an amino-acid sequence of a particular peptide or protein. Typically, a mature mRNA comprises a 5′-cap, a 5′-UTR, an open reading frame, a 3′-UTR and a poly(A) sequence. Aside from messenger RNA, several non-coding types of RNA exist which may be involved in regulation of transcription and/or translation.

Sequence of a nucleic acid molecule: The sequence of a nucleic acid molecule is typically understood to be the particular and individual order, i.e. the succession of its nucleotides. The sequence of a protein or peptide is typically understood to be the order, i.e. the succession of its amino acids.

Sequence identity: Two or more sequences are identical if they exhibit the same length and order of nucleotides or amino acids. The percentage of identity typically describes the extent to which two sequences are identical, i.e. it typically describes the percentage of nucleotides that correspond in their sequence position with identical nucleotides of a reference-sequence. For determination of the degree of identity, the sequences to be compared are considered to exhibit the same length, i.e. the length of the longest sequence of the sequences to be compared. This means that a first sequence consisting of 8 nucleotides is 80% identical to a second sequence consisting of 10 nucleotides comprising the first sequence. In other words, in the context of the present invention, identity of sequences preferably relates to the percentage of nucleotides of a sequence which have the same position in two or more sequences having the same length. Gaps are usually regarded as non-identical positions, irrespective of their actual position in an alignment.

Stabilized nucleic acid molecule: A stabilized nucleic acid molecule is a nucleic acid molecule, preferably a DNA or RNA molecule that is modified such, that it is more stable to disintegration or degradation, e.g., by environmental factors or enzymatic digest, such as by an exo- or endonuclease degradation, than the nucleic acid molecule without the modification. Preferably, a stabilized nucleic acid molecule in the context of the present invention is stabilized in a cell, such as a prokaryotic or eukaryotic cell, preferably in a mammalian cell, such as a human cell. The stabilization effect may also be exerted outside of cells, e.g. in a buffer solution etc., for example, in a manufacturing process for a pharmaceutical composition comprising the stabilized nucleic acid molecule.

Transfection: The term “transfection” refers to the introduction of nucleic acid molecules, such as DNA or RNA (e.g. mRNA) molecules, into cells, preferably into eukaryotic cells. In the context of the present invention, the term “transfection” encompasses any method known to the skilled person for introducing nucleic acid molecules into cells, preferably into eukaryotic cells, such as into mammalian cells. Such methods encompass, for example, electroporation, lipofection, e.g. based on cationic lipids and/or liposomes, calcium phosphate precipitation, nanoparticle based transfection, virus based transfection, or transfection based on cationic polymers, such as DEAE-dextran or polyethylenimine etc. Preferably, the introduction is non-viral.

Vaccine: A vaccine is typically understood to be a prophylactic or therapeutic material providing at least one antigen, preferably an immunogen. The antigen or immunogen may be derived from any material that is suitable for vaccination. For example, the antigen or immunogen may be derived from a pathogen, such as from bacteria or virus particles etc., or from a tumor or cancerous tissue. The antigen or immunogen stimulates the body's adaptive immune system to provide an adaptive immune response.

Vector: The term “vector” refers to a nucleic acid molecule, preferably to an artificial nucleic acid molecule. A vector in the context of the present invention is suitable for incorporating or harboring a desired nucleic acid sequence, such as a nucleic acid sequence comprising an open reading frame. Such vectors may be storage vectors, expression vectors, cloning vectors, transfer vectors etc. A storage vector is a vector, which allows the convenient storage of a nucleic acid molecule, for example, of an mRNA molecule. Thus, the vector may comprise a sequence corresponding, e.g., to a desired mRNA sequence or a part thereof, such as a sequence corresponding to the coding sequence and the 3′-UTR of an mRNA. An expression vector may be used for production of expression products such as RNA, e.g. mRNA, or peptides, polypeptides or proteins. For example, an expression vector may comprise sequences needed for transcription of a sequence stretch of the vector, such as a promoter sequence, e.g. an RNA polymerase promoter sequence. A cloning vector is typically a vector that contains a cloning site, which may be used to incorporate nucleic acid sequences into the vector. A cloning vector may be, e.g., a plasmid vector or a bacteriophage vector. A transfer vector may be a vector, which is suitable for transferring nucleic acid molecules into cells or organisms, for example, viral vectors. A vector in the context of the present invention may be, e.g., an RNA vector or a DNA vector. Preferably, a vector is a DNA molecule. Preferably, a vector in the sense of the present application comprises a cloning site, a selection marker, such as an antibiotic resistance factor, and a sequence suitable for multiplication of the vector, such as an origin of replication. Preferably, a vector in the context of the present application is a plasmid vector.

Vehicle: A vehicle is typically understood to be a material that is suitable for storing, transporting, and/or administering a compound, such as a pharmaceutically active compound. For example, it may be a physiologically acceptable liquid, which is suitable for storing, transporting, and/or administering a pharmaceutically active compound.

3′-untranslated region (3′-UTR): Generally, the term “3′-UTR” refers to a part of the artificial nucleic acid molecule, which is located 3′ (i.e. “downstream”) of an open reading frame and which is not translated into protein. Typically, a 3′-UTR is the part of an mRNA which is located between the protein coding region (open reading frame (ORF) or coding sequence (CDS)) and the poly(A) sequence of the mRNA. In the context of the invention, the term 3′-UTR may also comprise elements, which are not encoded in the template, from which an RNA is transcribed, but which are added after transcription during maturation, e.g. a poly(A) sequence. A 3′-UTR of the mRNA is not translated into an amino acid sequence. The 3′-UTR sequence is generally encoded by the gene, which is transcribed into the respective mRNA during the gene expression process. The genomic sequence is first transcribed into pre-mature mRNA, which comprises optional introns. The pre-mature mRNA is then further processed into mature mRNA in a maturation process. This maturation process comprises the steps of 5′capping, splicing the pre-mature mRNA to excise optional introns and modifications of the 3′-end, such as polyadenylation of the 3′-end of the pre-mature mRNA and optional endo-/or exonuclease cleavages etc. In the context of the present invention, a 3′-UTR corresponds to the sequence of a mature mRNA, which is located between the stop codon of the protein coding region, preferably immediately 3′ to the stop codon of the protein coding region, and the poly(A) sequence of the mRNA. The term “corresponds to” means that the 3′-UTR sequence may be an RNA sequence, such as in the mRNA sequence used for defining the 3′-UTR sequence, or a DNA sequence, which corresponds to such RNA sequence. In the context of the present invention, the term “a 3′-UTR of a gene”, such as “a 3′-UTR of a ribosomal protein gene”, is the sequence, which corresponds to the 3′-UTR of the mature mRNA derived from this gene, i.e. the mRNA obtained by transcription of the gene and maturation of the pre-mature mRNA. The term “3′-UTR of a gene” encompasses the DNA sequence and the RNA sequence (both sense and antisense strand and both mature and immature) of the 3′-UTR.

5′-untranslated region (5′-UTR): A 5′-UTR is typically understood to be a particular section of messenger RNA (mRNA). It is located 5′ of the open reading frame of the mRNA. Typically, the 5′-UTR starts with the transcriptional start site and ends one nucleotide before the start codon of the open reading frame. The 5′-UTR may comprise elements for controlling gene expression, also called regulatory elements. Such regulatory elements may be, for example, ribosomal binding sites. The 5′-UTR may be post-transcriptionally modified, for example by addition of a 5′-CAP. In the context of the present invention, a 5′-UTR corresponds to the sequence of a mature mRNA, which is located between the 5′-CAP and the start codon. Preferably, the 5′-UTR corresponds to the sequence, which extends from a nucleotide located 3′ to the 5′-CAP, preferably from the nucleotide located immediately 3′ to the 5′-CAP, to a nucleotide located 5′ to the start codon of the protein coding region, preferably to the nucleotide located immediately 5′ to the start codon of the protein coding region. The nucleotide located immediately 3′ to the 5′-CAP of a mature mRNA typically corresponds to the transcriptional start site. The term “corresponds to” means that the 5′-UTR sequence may be an RNA sequence, such as in the mRNA sequence used for defining the 5′-UTR sequence, or a DNA sequence, which corresponds to such RNA sequence. In the context of the present invention, the term “a 5′-UTR of a gene” is the sequence, which corresponds to the 5′-UTR of the mature mRNA derived from this gene, i.e. the mRNA obtained by transcription of the gene and maturation of the pre-mature mRNA. The term “5′-UTR of a gene” encompasses the DNA sequence and the RNA sequence of the 5′-UTR. By the inventive embodiments such a 5′-UTR may be provided 5′-terminal to the coding sequence. Its length is typically less than 500, 400, 300, 250 or less than 200 nucleotides. In other embodiments its length may be in the range of at least 10, 20, 30 or 40, preferably up to 100 or 150, nucleotides.

5′Terminal Oligopyrimidine Tract (TOP): The 5′terminal oligopyrimidine tract (TOP) is typically a stretch of pyrimidine nucleotides located in the 5′ terminal region of a nucleic acid molecule, such as the 5′ terminal region of certain mRNA molecules or the 5′ terminal region of a functional entity, e.g. the transcribed region, of certain genes. The sequence starts with a cytidine, which usually corresponds to the transcriptional start site, and is followed by a stretch of usually about 3 to 30 pyrimidine nucleotides. For example, the TOP may comprise 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 or even more nucleotides. The pyrimidine stretch and thus the 5′ TOP ends one nucleotide 5′ to the first purine nucleotide located downstream of the TOP. Messenger RNA that contains a 5′terminal oligopyrimidine tract is often referred to as TOP mRNA. Accordingly, genes that provide such messenger RNAs are referred to as TOP genes. TOP sequences have, for example, been found in genes and mRNAs encoding peptide elongation factors and ribosomal proteins.

TOP motif: In the context of the present invention, a TOP motif is a nucleic acid sequence which corresponds to a 5′TOP as defined above. Thus, a TOP motif in the context of the present invention is preferably a stretch of pyrimidine nucleotides having a length of 3-30 nucleotides. Preferably, the TOP-motif consists of at least 3 pyrimidine nucleotides, preferably at least 4 pyrimidine nucleotides, preferably at least 5 pyrimidine nucleotides, more preferably at least 6 nucleotides, more preferably at least 7 nucleotides, most preferably at least 8 pyrimidine nucleotides, wherein the stretch of pyrimidine nucleotides preferably starts at its 5′end with a cytosine nucleotide. In TOP genes and TOP mRNAs, the TOP-motif preferably starts at its 5′end with the transcriptional start site and ends one nucleotide 5′ to the first purin residue in said gene or mRNA. A TOP motif in the sense of the present invention is preferably located at the 5′end of a sequence, which represents a 5′UTR, or at the 5′end of a sequence, which codes for a 5′UTR. Thus, preferably, a stretch of 3 or more pyrimidine nucleotides is called “TOP motif” in the sense of the present invention if this stretch is located at the 5′end of a respective sequence, such as the artificial nucleic acid molecule, the 5′UTR element of the artificial nucleic acid molecule, or the nucleic acid sequence which is derived from the 5′UTR of a TOP gene as described herein. In other words, a stretch of 3 or more pyrimidine nucleotides, which is not located at the 5′-end of a 5′UTR or a 5′UTR element but anywhere within a 5′UTR or a 5′UTR element, is preferably not referred to as “TOP motif”.

TOP gene: TOP genes are typically characterised by the presence of a 5′ terminal oligopyrimidine tract. Furthermore, most TOP genes are characterized by a growth-associated translational regulation. However, also TOP genes with a tissue specific translational regulation are known. As defined above, the 5′UTR of a TOP gene corresponds to the sequence of a 5′UTR of a mature mRNA derived from a TOP gene, which preferably extends from the nucleotide located 3′ to the 5′-CAP to the nucleotide located 5′ to the start codon. A 5′UTR of a TOP gene typically does not comprise any start codons, preferably no upstream AUGs (uAUGs) or upstream open reading frames (uORFs). Therein, upstream AUGs and upstream open reading frames are typically understood to be AUGs and open reading frames that occur 5′ of the start codon (AUG) of the open reading frame that should be translated. The 5′UTRs of TOP genes are generally rather short. The lengths of 5′UTRs of TOP genes may vary between 20 nucleotides up to 500 nucleotides, and are typically less than about 200 nucleotides, preferably less than about 150 nucleotides, more preferably less than about 100 nucleotides. Exemplary 5′UTRs of TOP genes in the sense of the present invention are the nucleic acid sequences extending from the nucleotide at position 5 to the nucleotide located immediately 5′ to the start codon (e.g. the ATG) in the sequences according to SEQ ID NOs: 1-1363 of the patent application WO2013/143700, whose disclosure is incorporated herewith by reference. In this context, a particularly preferred fragment of a 5′UTR of a TOP gene is a 5′UTR of a TOP gene lacking the 5′TOP motif. The terms “5′UTR of a TOP gene” or “5′-TOP UTR” preferably refer to the 5′UTR of a naturally occurring TOP gene.

RNA Encoding an Antibody or a Fragment Thereof

In a first aspect, the present invention provides an RNA comprising at least one coding sequence encoding an antibody, or a fragment or variant of an antibody.

As used herein, the term “antibody” refers to antibodies of any antibody format. Typically, an antibody recognizes (and binds to) an antigen. To this end, an antibody usually comprises at least one antigen-binding site, which is also referred to as “paratope” and which recognizes (and binds to) an epitope on the antigen. A paratope typically comprises a set of complementary determining regions (CDRs) and usually contains parts of the light chain and parts of the heavy chain of the antibody. For example, a paratope of native IgG comprises three CDRs of the heavy chain (CDRH1, CDRH2 and CDRH3) and three CDRs of the light chain (CDRL1, CDRL2, and CDRL3). The CDRs of an antibody are arranged in the antibody's variable region: CDRH1, CDRH2 and CDRH3 in the heavy chain variable region (V_(H)) and CDRL1, CDRL2, and CDRL3 in the light chain variable region (V_(L)). In addition, an antibody may comprise a constant region (on heavy and light chain: C_(H) and C_(L), respectively). In native IgG the heavy chain constant region comprises three domains (CH1, CH2 and CH3), whereas the light chain constant region comprises one domain only (see also FIG. 1). Accordingly, an antibody is typically an immunoglobulin or is derived from an immunoglobulin. An antibody may fulfil different functions by recognizing (and binding to) an antigen, such as neutralization, agglutination, precipitation and/or complement activation. Neutralizing antibodies typically block parts of the surface of a bacterial cell or virion to render its attack ineffective. In agglutination antibodies “glue together” (foreign) cells into clumps that are attractive targets for phagocytosis. In precipitation antibodies “glue together” serum-soluble antigens, forcing them to precipitate out of solution in clumps that are attractive targets for phagocytosis. In complement activation antibodies that are latched onto a (foreign) cell encourage complement to attack it with a membrane attack complex, thereby leading to lysis of the (foreign) cell or to encouragement of inflammation by chemotactically attracting inflammatory cells.

In the context of the present invention, an “RNA comprising at least one coding sequence encoding an antibody, or a fragment or variant of an antibody” includes any RNA which encodes an antibody or a fragment or variant of an antibody. More generally, the RNA of the present invention contains at least one coding region, wherein the at least one coding region codes for at least one antibody or a fragment or variant of an antibody. If more than one coding region is contained in the RNA molecule of the invention, the second, third etc. coding region may code for other peptides/proteins and/or may code for antibodies or fragments or variants thereof as well, which may be the same or distinct from the first antibody coding region. In a preferred embodiment, the inventive RNA contains at least two coding regions, all of them coding for identical or distinct antibodies or fragments or variants thereof. For example, distinct fragments of an antibody may be encoded by different coding regions on the same RNA molecule. In still another embodiment of the present invention, an inventive RNA may code for more than one antibody or a fragment or variant of an antibody within the same coding region. In summary, the inventive RNA may be mono-, bi- or multicistronic.

The RNA according to the invention can be single-stranded or double-stranded, linear or circular, or in particular in the form of mRNA. The RNA according to the invention is particularly preferably in the form of single-stranded RNA, even more preferably in the form of mRNA.

The RNA according to the invention preferably has a length of from 50 to 15,000 nucleotides, more preferably a length of from 50 to 10,000 nucleotides, even more preferably a length of from 500 to 10,000 nucleotides and most preferably a length of from 500 to 7,000, 500 to 5,000 or 700 to 3,000 nucleotides.

In the context of the present invention, the antibodies coded by the RNA according to the invention can be chosen from all antibodies, e.g. from all antibodies which are generated by recombinant methods or are naturally occurring and are known to a person skilled in the art from the prior art, in particular antibodies which are (can be) employed for therapeutic purposes or for diagnostic or for research purposes or have been found with particular diseases, e.g. cancer diseases, infectious diseases etc.

In the context of the present invention, antibodies or fragments or variants thereof, which are encoded by the RNA according to the invention, typically include all antibodies or fragments or variants thereof which are known to a person skilled in the art, e.g. naturally occurring antibodies or antibodies generated in a host organism by immunization, antibodies or fragments or variants thereof prepared by recombinant methods which have been isolated and identified from naturally occurring antibodies or antibodies generated in a host organism by (conventional) immunization or have been generated with the aid of molecular biology methods, as well as chimeric antibodies or fragments or variants thereof, human antibodies or fragments or variants thereof, humanized antibodies or fragments or variants thereof, bispecific antibodies or fragments or variants thereof, and intrabodies or fragments or variants thereof, i.e. antibodies expressed in cells and possibly localized in particular cell compartments.

RNA molecules according to the invention can also be prepared on the basis of polyclonal antibodies or fragments or variants thereof or, as an antibody-coding RNA cocktail, can have a polyclonal character. In the context of this invention, polyclonal antibodies are typically mixtures of antibodies against a specific antigen or immunogen or epitope of a protein which have been generated by immunization of a host organism, for example mammals, i.e. animals, including cattle, pigs, dogs, cats, donkeys, monkeys, including rodents, e.g. mice, hamsters, rabbits etc., and man. Polyclonal antibodies conventionally recognize different epitopes or regions of the same specific antigen, each of these epitopes in turn being capable of generating a clone of B lymphocytes which produces an antibody against this epitope. From such polyclonal antibodies or from the antibody sera obtained from the host organism, the individual antibodies specific against the particular epitopes can be obtained by individualization to monoclonal antibodies. The present invention accordingly also provides RNA which codes for a monoclonal antibody, or a fragment or variant thereof, obtained by individualization of polyclonal antibodies.

Monoclonal antibodies in the context of this invention are therefore typically antibodies which are specific for a particular antigen or epitope (of a protein), i.e. bind this antigen or epitope (of a protein) with a high affinity, and conventionally are expressed by a hybridoma cell. For the preparation of such monoclonal antibodies, the corresponding antigen or immunogen or epitope of a protein is typically injected at least once, but typically several times, into a host organism as described here, as a result of which the immune system of the host organism, in the presence of suitable adjuvants, is preferably stimulated to antibody production via activation of correspondingly specific B cells. The B lymphocytes are then conventionally selectively purified from the spleen or other organs or fluids suitable for this from an animal immunized in this manner, and are fused with an immortal myeloma cell to give the so-called hybridoma cell. After selection methods and cloning of the hybridomas or hybridoma cells formed, those clones which secernate, i.e. express and secrete, antibodies of the desired specificity can be determined. These clones can be isolated and sequenced with known molecular biology methods. The data obtained from such a sequencing can serve further in a nucleic acid synthesis for generation of synthetic DNA sequences or for screening a cDNA library and isolation of the cDNA fragments and generation of a DNA or nucleic acid template for in vitro or in vivo synthesis of the RNA according to the invention which codes for an antibody. Where appropriate, the RNA contained in the hybridomas can also be isolated, for example by fractionation, and subsequently the RNA molecules according to the invention which code for the hybridoman antibody can be purified by methods known to the person skilled in the art.

Nevertheless, RNA molecules which code for non-human monoclonal or polyclonal antibody or fragments or variants thereof, e.g. murine monoclonal antibodies or monoclonal antibodies from other, as described here, non-human host organisms or hybridoma cells are of only limited suitability for therapeutic use in humans, since in the human organism itself they conventionally cause an immune reaction with formation of human anti-antibodies directed against these non-human host antibodies. As a result, such non-human monoclonal or polyclonal antibodies as a rule can be administered to a person only a single time. To by-pass this problem, RNA molecules which code for chimeric, humanized and human antibodies can also be provided according to the invention.

Chimeric antibodies in the context of the present invention are preferably antibodies in which the constant domains of an antibody as described here have been replaced by human sequences. Preferably, chimeric antibodies are formed from monoclonal or polyclonal antibodies as described here.

Humanized antibodies in the context of the present invention are antibodies in which the constant and variable regions described above of the non-human monoclonal or polyclonal antibodies, with the exception of the hypervariable regions, have been replaced by human sequences.

RNA molecules which code for human antibodies, i.e. antibodies which have human sequences, that is to say in the constant regions (if present) and in the variable regions, including the hypervariable regions, or fragments or variants thereof can furthermore be used in the context of the present invention. Such RNA molecules which code for human antibodies can be isolated from human tissue or originate from immunized host organisms as described here, e.g. mice, which are then transgenic for the human IgG gene locus.

Preferably, the at least one coding sequence of the RNA according to the invention encodes an antibody, preferably as defined herein, or a fragment or variant thereof, wherein the antibody is preferably selected from the group consisting of AAB-003; Abagovomab; Abciximab; Abituzumab; Abrilumab; Actoxumab; Adalimumab; Aducanumab; Afasevikumab; Aflibercept; Afutuzuab; Afutuzumab; Alacizumab_pegol; Alemtuzumab; Alirocumab; ALX-0061; Amatuximab; Anetumab_ravtansine; Anifrolumab; Anrukinzumab; Apolizumab; Apomab; Aquaporumab; Arcitumomab_99tc; Ascrinvacumab; Aselizuab; Atezolizumab; Atinumab; Atlizuab; Aurograb; Avelumab; Bapineuzumab; Basiliximab; Bavituximab; Begelomab; Benralizumab; Betalutin; Bevacituzuab; Bevacizumab_154-aspartic_acid; Bevacizumab_(—) 154-substitution; Bevacizumab_180-serine; Bevacizumab_180-substitution; Bevacizumab_beta; Bevacizumab; Bevacizumab-rhuMAb-VEGF; Bezlotoxumab; Bimagrumab; Bimekizumab; Bleselumab; Blinatumomab; Blinatumumab; Blontuvetmab; Blosozumab; Bococizumab; Brentuximab_vedotin; Briakinumab; Brodalumab; Brolucizumab; Brontictuzumab; BTT-1023; Burosumab; Canakinumab; Cantuzumab; Cantuzumab_mertansine; Cantuzumab_ravtansine; Caplacizumab; Carlumab; Cergutuzumab_amunaleukin; Certolizumab_pegol; Cetuximab; Citatuzumab_bogatox; Cixutumumab; Clazakizumab; Clivatuzumab_tetraxetan; Codrituzumab; Coltuximab_ravtansine; Conatumumab_CV; Conatumumab; Concizumab; Crenezumab; Crotedumab; Dacetuzumab; Dacliximab; Daclizumab; Dalotuzumab; Dapirolizumab_pegol; Daratumumab; Dectrekumab; Demcizumab; Denintuzumab_mafodotin; Denosumab; Depatuxizumab; Depatuxizumab_mafodotin; Dinutuximab_beta; Dinutuximab; Diridavumab; Domagrozumab; Drozituab; Drozitumab; Duligotumab; Duligotuzumab; Dupilumab; Durvalumab; Dusigitumab; Ecromeximab; Eculizumab; Efalizumab; Efungumab; Eldelumab; Elgemtumab; Elotuzumab; Emactuzumab; Emibetuzumab; Emicizumab; Enavatuzumab; Enfortumab; Enfortumabvedotin; Enoblituzumab; Enokizumab; Enoticumab; Ensituximab; Entolimod; Epratuzumab; Eptacog_beta; Erlizuab; Etaracizumab; Etrolizuab; Etrolizumab; Evinacumab; Evolocumab; Exbivirumab; Farletuzumab; Fasinumab; Fezakinumab; FG-3019; Fibatuzumab; Ficlatuzumab; Figitumumab; Firivumab; Flanvotumab; Fletikumab; Fontolizumab; Foralumab; Foravirumab; Fresolimumab; Fulranumab; Futuximab; Galcanezumab; Galiximab; Ganitumab; Gantenerumab; Gemtuzumab; Gemtuzumab_ozogamicin; Gevokizumab; Girentuximab; Glembatumumab; Goilixiab; Guselkumab; HuMab-001; HuMab-005; HuMab-006; HuMab-019; HuMab-021; HuMab-025; HuMab-027; HuMab-032; HuMab-033; HuMab-035; HuMab-036; HuMab-041; HuMab-044; HuMab-049; HuMab-050; HuMab-054; HuMab-055; HuMab-059; HuMab-060; HuMab-067; HuMab-072; HuMab-084; HuMab-091; HuMab-093; HuMab-098; HuMab-100; HuMab-106; HuMab_10F8; HuMab-111; HuMab-123; HuMab-124; HuMab-125; HuMab-127; HuMab-129; HuMab-132; HuMab-143; HuMab-150; HuMab-152; HuMab-153; HuMab-159; HuMab-160; HuMab-162; HuMab-163; HuMab-166; HuMab-167; HuMab-169; HuMab-7D8; huMAb-anti-MSP10.1; huMAb-anti-MSP10.2; HUMAB-Clone_18; HUMAB-Clone_22; HuMab-L612; HuMab_LC5002-002; HuMab_LC5002-003; HuMab_LC5002-005; HuMab_LC5002-007; HuMab_LC5002-018; Ibalizumab; Ibritumomab_tiuxetan; Icrucumab; Idarucizumab; Igatuzuab; IGF-IR_HUMAB-1A; IGF-IR_HUMAB-23; IGF-IR_HUMAB-8; ImAb1; Imalumab; Imgatuzumab; Inclacumab; Indatuximab_ravtansine; Indusatumab_vedotin; Inebilizumab; Insulin_peglispro; Interferon_beta-1b; Intetumumab; Iodine_(124I)_Girentuximab; lodine_(131I)_Derlotuxiab_biotin; lodine_(131I)_Derlotuximab_biotin; Ipilimumab; Iratumumab; Isatuximab; Itolizumab; Ixekizumab; Labetuzumab_govitecan; Lambrolizumab; Lampalizumab; Lanadelumab; Landogrozumab; Laprituximab_emtansine; Lealesoab; Lebrikizumab; Lenercept_chain1; Lenzilumab; Lerdelimumab; Lexatumumab; Libivirumab; Lifastuzumab; Lifastuzumab_vedotin; Ligelizumab; Lilotomab; Lintuzumab; Lirilumab; Lodelcizumab; Lokivetmab; Lorvotuzumab_mertansine; Lpathomab; Lucatumumab; Lulizumab_pegol; Lumiliximab; Lumretuzumab; Lutetium_(177Lu)_Iilotomab_satetraxetan; Margetuximab; Marzeptacog_alfa; Matuzumab; Mavrilimumab; MDX-1303; Mepolizumab; Metelimumab; Milatuzumab; Mirvetuximab; Modotuximab; Mogamulizumab; Monalizumab; Motavizumab; Moxetumomab_pasudotox; Muromonab-CD3; Namilumab; Naptumomab_estafenatox; Narnatumab; Natalizumab; Navicixizumab; Navivumab; Ndimab-varB; Necitumumab; Neliximab; Nemolizumab; Nesvacumab; Neuradiab; Nimotuzumab; Nivolumab; Obiltoxaximab; Obinutuzumab; Ocaratuzumab; Ocrelizumab; Ofatumumab; Olaratumab; Olizuab; Olokizumab; Omalizumab; Onartuzumab; Ontuxizumab; Opicinumab; Oportuzumab_monatox; Oreptacog_alfa; Orticumab; Otelixizumab; Otlertuzumab; Oxelumab; Ozanezumab; Ozoralizumab; Palivizumab; Pamrevlumab; Panitumumab; Pankoab; PankoMab; Panobacumab; Parsatuzumab; Pascolizumab; Pasotuxizumab; Pateclizumab; Patritumab; Pembrolizumab; Perakizumab; Pertuzuab; Pertuzumab; Pexelizumab_h5g1.1-scFv; Pexelizumab; PF-05082566; PF-05082568; Pidilizumab; Pinatuzumab_vedotin; Placulumab; Plozalizumab; Pogalizumab; Polatuzumab_vedotin; Ponezumab; Pritoxaximab; Pritumumab; Quilizumab; Racotumomab; Radretumab; Rafivirumab; Ralpancizumab; Ramucirumab; Ranibizivab; Ranibizumab; Refanezumab; REGN2810; rhuMab_HER2(9CI); rhuMab_HER2; rhuMAb-VEGF; Rilotumumab; Rinucumab; Risankizumab; Rituximab; Rivabazumab_pegol; Robatumumab; Roledumab; Romosozumab; Rontalizuab; Rontalizumab; Rovalpituzumab_tesirine; Rovelizumab; Ruplizumab; Sacituzumab_govitecan; Samalizumab; Sarilumab; Satumomab_pendetide; Secukinumab; Seribantumab; Setoxaximab; Sifalimumab; Siltuximab; Simtuzumab; Sirukumab; Sofituzumab_vedotin; Solanezumab; Solitomab; Sonepcizumab; Stamulumab; Suptavumab; Suvizumab; Tabalumab; Tacatuzuab; Tadocizumab; Talizumab; Tamtuvetmab; Tanezumab; Tarextumab; Tefibazumab; Tenatumomab; Teneliximab; Teplizumab; Teprotumumab; Tesidolumab; Tezepelumab; ThioMAb-chMA79b-HC(A118C); ThioMab-hu10A8.v1-HC(A118C); ThioMab-hu10A8.v1-HC(V205C); ThioMab-hu10A8.v1-LC(A118C); ThioMab-hu10A8.v1-LC(V205C); ThioMAb-huMA79b.v17-HC(A118C); ThioMAb-huMA79b.v18-HC(A118C); ThioMAb-huMA79b.v28-HC(A118C); ThioMAb-huMA79b.v28-LC(V205C); Ticilivab; Tigatuzumab; Tildrakizumab; Tisotumab_vedotin; Tocilizumab; Tosatoxumab; Tositumomab; Tovetumab; Tralokinumab; Trastuzuab; Trastuzumab_emtansine; Trastuzumab; TRC-105; Tregalizumab; Tremelimumab; Trevogrumab; Tucotuzumab_celmoleukin; Ublituximab; Ulocuplumab; Urelumab; Urtoxazumab; Ustekinumab; Vadastuximab_talirine; Vandortuzumab_vedotin; Vantictumab; Vanucizumab; Varlilumab; Vatelizumab; Vedolizumab; Veltuzumab; Vesencumab; Visilizumab; Volociximab; Vorsetuzumab; Vorsetuzumab_mafodotin; Yttrium_(90Y)_clivatuzumab_tetraxetan; Yttrium_Y_90_epratuzumab_tetraxetan; Yttrium_Y_90_epratuzumab; Zalutumumab; Zanolimumab; Zatuximab; Andecaliximab; Aprutumab; Azintuxizumab; Brazikumab; Cabiralizumab; Camrelizumab; Cosfroviximab; Crizanlizumab; Dezamizumab; Duvortuxizumab; Elezanumab; Emapalumab; Eptinezumab; Erenumab; Fremanezumab; Frunevetmab; Gatipotuzumab; Gedivumab; Gemetuzumab; Gilvetmab; Ifabotuzumab; Lacnotuzumab; Larcaviximab; Lendalizumab; Lesofavumab; Letolizumab; Losatuxizumab; Lupartumab; Lutikizumab; Oleclumab; Porgaviximab; Prezalumab; Ranevetmab; Remtolumab; Rosmantuzumab; Rozanolixizumab; Sapelizumab; Selicrelumab; Suvratoxumab; Tavolixizumab; Telisotuzumab; Telisotuzumab_vedotin; Timigutuzumab; Timolumab; Tomuzotuximab; Trastuzumab_duocarmazine; Varisacumab; Vunakizumab; Xentuzumab; anti-rabies_SO57; anti-rabies_SOJB; anti-rabies_SOJA; anti-rabies; anti-RSV_5ITB; anti-alpha-toxin_4U6V; anti-IsdB_5D1Q; anti-IsdB_5D1X; anti-IsdB_5D1Z; anti-HIV_b12; anti-HIV_2G12; anti-HIV_4E10; anti-HIV_VRC01; anti-HIV_PG9; anti-HIV_VRC07; anti-HIV_3BNC117; anti-HIV_10-1074; anti-HIV_PGT121; anti-HIV_PGDM1400; anti-HIV_N6; anti-HIV_10E8; anti-HIV_12A12; anti-HIV_12A21; anti-HIV_35022; anti-HIV_3BC176; anti-HIV_3BNC55; anti-HIV_3BNC60; anti-HIV_447-52D; anti-HIV_5H/I1-BMV-D5; anti-HIV_8ANC195; anti-HIV_CAP256-VRC26.01; anti-HIV_CAP256-VRC26.02; anti-HIV_CAP256-VRC26.03; anti-HIV_CAP256-VRC26.04; anti-HIV_CAP256-VRC26.05; anti-HIV_CAP256-VRC26.06; anti-HIV_CAP256-VRC26.07; anti-HIV_CAP256-VRC26.08; anti-HIV_CAP256-VRC26.09; anti-HIV_CAP256-VRC26.10; anti-HIV_CAP256-VRC26.11; anti-HIV_CAP256-VRC26.12; anti-HIV_CAP256-VRC26.I1; anti-HIV_CAP256-VRC26.I2; anti-HIV_CAP256-VRC26.UCA; anti-HIV_CH01; anti-HIVCH02; anti-HIV_CH03; anti-HIV_CH04; anti-HIV_CH103; anti-HIV_M66.6; anti-HIV_NIH45-46; anti-HIV_PG16; anti-HIV_PGT122; anti-HIV_PGT123; anti-HIV_PGT125; anti-HIV_PGT126; anti-HIV_PGT127; anti-HIV_PGT128; anti-HIV_PGT130; anti-HIV_PGT131; anti-HIV_PGT135; anti-HIV_PGT136; anti-HIV_PGT137; anti-HIV_PGT141; anti-HIV_PGT142; anti-HIV_PGT143; anti-HIV_PGT144; anti-HIV_PGT145; anti-HIV_PGT151; anti-HIV_PGT152; anti-HIV_VRC-CH30; anti-HIV_VRC-CH31; anti-HIV_VRC-CH32; anti-HIV_VRC-CH33; anti-HIV_VRC-CH34; anti-HIV_VRC-PG04; anti-HIV_VRC-PG04b; anti-HIV_VRC-PG20; anti-HIV_VRC02; anti-HIV_VRC03; anti-HIV_VRC23; anti-HIV_SCCK; anti-HIV_SAWN; anti-HIV_3QEG; anti-HIV_1N0X; anti-HIV_3QEH; anti-HIV_2B1H; anti-HIV_3TNM; anti-HIV_3UJJ; anti-HIV_3UJI; anti-HIV_2QSC; anti-HIV_3MLZ; anti-HIV_3MLX; anti-HIV_3MLW; anti-HIV_3MLV; anti-HIV_3MLU; anti-HIV_3MLT; anti-HIV_3GO1; anti-HIV_4XCY; anti-HIV_4YBL; anti-HIV_4R4N; anti-HIV_4R4B; anti-HIV_3JUY; anti-HIV_4KG5; anti-HIV-1; anti-HIV_V3; anti-HIV_CD4bs; anti-HIV_V2; anti-HIV_C38-VRC18.02; anti-HIV_44-VRC13.02; anti-HIV_45; anti-HIV_cap256-206-252885; anti-HIV_cap256-206-249183; anti-HIV_cap256-206-220956; anti-HIV_cap256-206-220629; anti-HIV_cap256-206-200599; anti-HIV_cap256-206-186347; anti-HIV_cap256-206-186226; anti-HIV_cap256-206-179686; anti-HIV_cap256-206-173707; anti-HIV_cap256-206-173339; anti-HIV_cap256-206-172689; anti-HIV_cap256-206-162744; anti-HIV_cap256-206-146057; anti-HIV_cap256-206-139519; anti-HIV_cap256-206-136316; anti-HIV_cap256-206-116098; anti-HIV_cap256-206-115862; anti-HIV_cap256-206-107018; anti-HIV_cap256-206-098644; anti-HIV_cap256-206-098135; anti-HIV_cap256-206-096276; anti-HIV_cap256-206-092794; anti-HIV_cap256-206-086817; anti-HIV_cap256-206-086446; anti-HIV_cap256-206-086180; anti-HIV_cap256-206-083708; anti-HIV_cap256-206-079556; anti-HIV_cap256-206-078657; anti-HIV_cap256-206-075802; anti-HIV_cap256-206-069097; anti-HIV_cap256-206-067758; anti-HIV_cap256-206-057019; anti-HIV_cap256-206-055385; anti-HIV_cap256-206-053187; anti-HIV_cap256-206-053139; anti-HIV_cap256-206-050350; anti-HIV_cap256-206-046207; anti-HIV_cap256-206-043389; anti-HIV_cap256-206-042555; anti-HIV_cap256-206-029720; anti-HIV_cap256-206-028848; anti-HIV_cap256-206-027652; anti-HIV_cap256-206-024075; anti-HIV_cap256-206-008748; anti-HIV_cap256-206-008530; anti-HIV_cap256-176-723043; anti-HIV_cap256-176-600049; anti-HIV_cap256-176-531926; anti-HIV_cap256-176-504134; anti-HIV_cap256-119-186229; anti-HIV_cap256-119-183891; anti-HIV_cap256-119-183631; anti-HIV_cap256-119-182676; anti-HIV_cap256-119-180772; anti-HIV_cap256-119-180508; anti-HIV_cap256-119-180260; anti-HIV_cap256-119-180173; anti-HIV_cap256-119-179839; anti-HIV_cap256-119-179262; anti-HIV_cap256-119-178995; anti-HIV_cap256-119-178455; anti-HIV_cap256-119-177993; anti-HIV_cap256-119-177727; anti-HIV_cap256-119-176746; anti-HIV_cap256-119-176241; anti-HIV_cap256-119-175215; anti-HIV_cap256-119-173928; anti-HIV_cap256-119-173495; anti-HIV_cap256-119-172882; anti-HIV_cap256-119-172429; anti-HIV_cap256-119-172223; anti-HIV_cap256-119-171838; anti-HIV_cap256-119-171587; anti-HIV_cap256-119-169596; anti-HIV_cap256-119-169523; anti-HIV_cap256-119-169462; anti-HIV_cap256-119-169092; anti-HIV_cap256-119-168680; anti-HIV_cap256-119-166385; anti-HIV_cap256-119-165943; anti-HIV_cap256-119-165738; anti-HIV_cap256-119-164913; anti-HIV_cap256-119-164167; anti-HIV_cap256-119-163558; anti-HIV_cap256-119-162043; anti-HIV_cap256-119-161718; anti-HIV_cap256-119-161675; anti-HIV_cap256-119-161053; anti-HIV_cap256-119-159499; anti-HIV_cap256-119-159114; anti-HIV_cap256-119-156751; anti-HIV_cap256-119-155656; anti-HIV_cap256-119-154420; anti-HIV_cap256-119-153954; anti-HIV_cap256-119-153864; anti-HIV_cap256-119-153793; anti-HIV_cap256-119-153462; anti-HIV_cap256-119-153124; anti-HIV_cap256-119-153025; anti-HIV_cap256-119-152713; anti-HIV_cap256-119-151794; anti-HIV_cap256-119-150980; anti-HIV_cap256-119-148895; anti-HIV_cap256-119-148848; anti-HIV_cap256-119-148743; anti-HIV_cap256-119-148595; anti-HIV_cap256-119-148490; anti-HIV_cap256-119-148470; anti-HIV_cap256-119-148107; anti-HIV_cap256-119-147933; anti-HIV_cap256-119-147434; anti-HIV_cap256-119-146106; anti-HIV_cap256-119-145604; anti-HIV_cap256-119-143998; anti-HIV_cap256-119-143441; anti-HIV_cap256-119-141307; anti-HIV_cap256-119-140896; anti-HIV_cap256-119-140090; anti-HIV_cap256-119-140037; anti-HIV_cap256-119-139135; anti-HIV_cap256-119-137881; anti-HIV_cap256-119-137643; anti-HIV_cap256-119-137170; anti-HIV_cap256-119-136616; anti-HIV_cap256-119-136206; anti-HIV_cap256-119-135565; anti-HIV_cap256-119-135025; anti-HIV_cap256-119-133983; anti-HIV_cap256-119-133917; anti-HIV_cap256-119-132663; anti-HIV_cap256-119-132113; anti-HIV_cap256-119-131839; anti-HIV_cap256-119-130626; anti-HIV_cap256-119-130191; anti-HIV_cap256-119-129798; anti-HIV_cap256-119-128745; anti-HIV_cap256-119-128593; anti-HIV_cap256-119-128152; anti-HIV_cap256-119-127693; anti-HIV_cap256-119-126684; anti-HIV_cap256-119-126056; anti-HIV_cap256-119-125765; anti-HIV_cap256-119-125106; anti-HIV_cap256-119-124026; anti-HIV_cap256-119-121783; anti-HIV_cap256-119-121208; anti-HIV_cap256-119-120945; anti-HIV_cap256-119-118229; anti-HIV_cap256-119-118025; anti-HIV_cap256-119-117418; anti-HIV_cap256-119-117250; anti-HIV_cap256-119-117230; anti-HIV_cap256-119-116999; anti-HIV_cap256-119-116558; anti-HIV_cap256-119-116484; anti-HIV_cap256-119-114844; anti-HIV_cap256-119-114141; anti-HIV_cap256-119-111917; anti-HIV_cap256-119-111862; anti-HIV_cap256-119-110064; anti-HIV_cap256-119-109192; anti-HIV_cap256-119-108793; anti-HIV_cap256-119-108127; anti-HIV_cap256-119-107758; anti-HIV_cap256-119-107209; anti-HIV_cap256-119-107184; anti-HIV_cap256-119-106827; anti-HIV_cap256-119-106511; anti-HIV_cap256-119-106327; anti-HIV_cap256-119-105486; anti-HIV_cap256-119-105197; anti-HIV_cap256-119-104946; anti-HIV_cap256-119-103667; anti-HIV_cap256-119-103385; anti-HIV_cap256-119-103267; anti-HIV_cap256-119-103011; anti-HIV_cap256-119-102072; anti-HIV_cap256-119-101945; anti-HIV_cap256-119-101319; anti-HIV_cap256-119-100871; anti-HIV_cap256-119-100838; anti-HIV_cap256-119-100025; anti-HIV_cap256-119-100000; anti-HIV_cap256-119-098890; anti-HIV_cap256-119-098715; anti-HIV_cap256-119-098632; anti-HIV_cap256-119-097199; anti-HIV_cap256-119-096189; anti-HIV_cap256-119-094581; anti-HIV_cap256-119-094200; anti-HIV_cap256-119-094158; anti-HIV_cap256-119-092814; anti-HIV_cap256-119-092808; anti-HIV_cap256-119-092573; anti-HIV_cap256-119-090815; anti-HIV_cap256-119-090368; anti-HIV_cap256-119-089710; anti-HIV_cap256-119-088555; anti-HIV_cap256-119-087962; anti-HIV_cap256-119-086903; anti-HIV_cap256-119-086804; anti-HIV_cap256-119-085910; anti-HIV_cap256-119-085772; anti-HIV_cap256-119-084603; anti-HIV_cap256-119-084276; anti-HIV_cap256-119-082288; anti-HIV_cap256-119-080383; anti-HIV_cap256-119-079333; anti-HIV_cap256-119-078618; anti-HIV_cap256-119-077466; anti-HIV_cap256-119-076284; anti-HIV_cap256-119-074680; anti-HIV_cap256-119-074081; anti-HIV_cap256-119-071704; anti-HIV_cap256-119-071266; anti-HIV_cap256-119-069667; anti-HIV_cap256-119-069591; anti-HIV_cap256-119-068691; anti-HIV_cap256-119-068488; anti-HIV_cap256-119-067536; anti-HIV_cap256-119-065852; anti-HIV_cap256-119-065457; anti-HIV_cap256-119-064501; anti-HIV_cap256-119-063568; anti-HIV_cap256-119-063103; anti-HIV_cap256-119-061027; anti-HIV_cap256-119-058232; anti-HIV_cap256-119-057341; anti-HIV_cap256-119-056895; anti-HIV_cap256-119-056402; anti-HIV_cap256-119-056034; anti-HIV_cap256-119-055042; anti-HIV_cap256-119-054776; anti-HIV_cap256-119-054539; anti-HIV_cap256-119-054112; anti-HIV_cap256-119-053339; anti-HIV_cap256-119-052404; anti-HIV_cap256-119-051123; anti-HIV_cap256-119-051077; anti-HIV_cap256-119-050442; anti-HIV_cap256-119-049433; anti-HIV_cap256-119-047532; anti-HIV_cap256-119-047489; anti-HIV_cap256-119-046020; anti-HIV_cap256-119-044746; anti-HIV_cap256-119-044740; anti-HIV_cap256-119-043790; anti-HIV_cap256-119-042880; anti-HIV_cap256-119-042606; anti-HIV_cap256-119-042444; anti-HIV_cap256-119-040328; anti-HIV_cap256-119-040164; anti-HIV_cap256-119-039130; anti-HIV_cap256-119-038138; anti-HIV_cap256-119-037868; anti-HIV_cap256-119-037102; anti-HIV_cap256-119-036683; anti-HIV_cap256-119-036495; anti-HIV_cap256-119-035375; anti-HIV_cap256-119-035165; anti-HIV_cap256-119-035109; anti-HIV_cap256-119-033789; anti-HIV_cap256-119-033641; anti-HIV_cap256-119-032113; anti-HIV_cap256-119-031739; anti-HIV_cap256-119-030932; anti-HIV_cap256-119-030740; anti-HIV_cap256-119-030197; anti-HIV_cap256-119-027047; anti-HIV_cap256-119-026950; anti-HIV_cap256-119-026279; anti-HIV_cap256-119-025355; anti-HIV_cap256-119-025301; anti-HIV_cap256-119-025010; anti-HIV_cap256-119-024631; anti-HIV_cap256-119-024467; anti-HIV_cap256-119-023805; anti-HIV_cap256-119-021736; anti-HIV_cap256-119-021203; anti-HIV_cap256-119-020569; anti-HIV_cap256-119-019432; anti-HIV_cap256-119-018827; anti-HIV_cap256-119-018483; anti-HIV_cap256-119-018118; anti-HIV_cap256-119-017782; anti-HIV_cap256-119-017669; anti-HIV_cap256-119-016976; anti-HIV_cap256-119-015432; anti-HIV_cap256-119-015281; anti-HIV_cap256-119-014957; anti-HIV_cap256-119-014777; anti-HIV_cap256-119-014313; anti-HIV_cap256-119-014219; anti-HIV_cap256-119-013631; anti-HIV_cap256-119-012924; anti-HIV_cap256-119-011793; anti-HIV_cap256-119-011413; anti-HIV_cap256-119-011323; anti-HIV_cap256-119-011233; anti-HIV_cap256-119-009038; anti-HIV_cap256-119-008756; anti-HIV_cap256-119-008055; anti-HIV_cap256-119-006949; anti-HIV_cap256-119-006685; anti-HIV_cap256-119-006015; anti-HIV_cap256-119-005841; anti-HIV_cap256-119-005824; anti-HIV_cap256-119-005494; anti-HIV_cap256-119-004949; anti-HIV_cap256-119-004422; anti-HIV_cap256-119-003932; anti-HIV_cap256-119-003577; anti-HIV_cap256-119-002155; anti-HIV_cap256-119-002017; anti-HIV_cap256-119-001312; anti-HIV_cap256-119-001017; anti-HIV_cap256-119-000594; anti-HIV_cap256-059-241099; anti-HIV_cap256-059-207529; anti-HIV_cap256-059-205541; anti-HIV_cap256-059-188439; anti-HIV_cap256-059-187234; anti-HIV_cap256-059-187047; anti-HIV_cap256-059-186068; anti-HIV_cap256-059-182835; anti-HIV_cap256-059-176659; anti-HIV_cap256-059-172956; anti-HIV_cap256-059-171272; anti-HIV_cap256-059-168734; anti-HIV_cap256-059-155838; anti-HIV_cap256-059-149799; anti-HIV_cap256-059-148168; anti-HIV_cap256-059-144685; anti-HIV_cap256-059-140017; anti-HIV_cap256-059-137547; anti-HIV_cap256-059-131908; anti-HIV_cap256-059-116006; anti-HIV_cap256-059-115783; anti-HIV_cap256-059-114609; anti-HIV_cap256-059-113952; anti-HIV_cap256-059-113878; anti-HIV_cap256-059-113622; anti-HIV_cap256-059-109427; anti-HIV_cap256-059-109081; anti-HIV_cap256-059-107590; anti-HIV_cap256-059-107504; anti-HIV_cap256-059-099614; anti-HIV_cap256-059-098972; anti-HIV_cap256-059-097236; anti-HIV_cap256-059-091487; anti-HIV_cap256-059-089812; anti-HIV_cap256-059-088468; anti-HIV_cap256-059-088341; anti-HIV_cap256-059-086533; anti-HIV_cap256-059-086043; anti-HIV_cap256-059-084191; anti-HIV_cap256-059-082135; anti-HIV_cap256-059-079417; anti-HIV_cap256-059-076027; anti-HIV_cap256-059-075082; anti-HIV_cap256-059-072575; anti-HIV_cap256-059-071926; anti-HIV_cap256-059-069638; anti-HIV_cap256-059-069165; anti-HIV_cap256-059-068956; anti-HIV_cap256-059-068876; anti-HIV_cap256-059-067733; anti-HIV_cap256-059-067450; anti-HIV_cap256-059-065694; anti-HIV_cap256-059-065109; anti-HIV_cap256-059-065060; anti-HIV_cap256-059-064001; anti-HIV_cap256-059-063270; anti-HIV_cap256-059-061357; anti-HIV_cap256-059-059834; anti-HIV_cap256-059-059313; anti-HIV_cap256-059-057130; anti-HIV_cap256-059-050520; anti-HIV_cap256-059-049839; anti-HIV_cap256-059-048503; anti-HIV_cap256-059-045516; anti-HIV_cap256-059-044188; anti-HIV_cap256-059-044105; anti-HIV_cap256-059-042100; anti-HIV_cap256-059-040742; anti-HIV_cap256-059-040554; anti-HIV_cap256-059-039660; anti-HIV_cap256-059-039298; anti-HIV_cap256-059-037873; anti-HIV_cap256-059-037633; anti-HIV_cap256-059-036817; anti-HIV_cap256-059-032787; anti-HIV_cap256-059-032427; anti-HIV_cap256-059-029390; anti-HIV_cap256-059-027877; anti-HIV_cap256-059-026640; anti-HIV_cap256-059-026017; anti-HIV_cap256-059-024100; anti-HIV_cap256-059-023966; anti-HIV_cap256-059-020534; anti-HIV_cap256-059-019513; anti-HIV_cap256-059-012963; anti-HIV_cap256-059-010396; anti-HIV_cap256-059-008136; anti-HIV_cap256-059-006147; anti-HIV_cap256-059-005081; anti-HIV_cap256-059-005006; anti-HIV_cap256-059-004451; anti-HIV_cap256-059-003571; anti-HIV_cap256-059-003449; anti-HIV_cap256-059-002712; anti-HIV_cap256-059-001573; anti-HIV_cap256-059-001379; anti-HIV_cap256-059-001029; anti-HIV_cap256-048-165087; anti-HIV_cap256-048-158861; anti-HIV_cap256-048-158280; anti-HIV_cap256-048-157928; anti-HIV_cap256-048-157056; anti-HIV_cap256-048-156422; anti-HIV_cap256-048-152863; anti-HIV_cap256-048-152770; anti-HIV_cap256-048-150027; anti-HIV_cap256-048-148246; anti-HIV_cap256-048-147428; anti-HIV_cap256-048-146603; anti-HIV_cap256-048-145735; anti-HIV_cap256-048-145116; anti-HIV_cap256-048-144077; anti-HIV_cap256-048-142876; anti-HIV_cap256-048-140582; anti-HIV_cap256-048-139355; anti-HIV_cap256-048-139151; anti-HIV_cap256-048-137672; anti-HIV_cap256-048-137506; anti-HIV_cap256-048-137270; anti-HIV_cap256-048-135447; anti-HIV_cap256-048-131966; anti-HIV_cap256-048-131008; anti-HIV_cap256-048-129369; anti-HIV_cap256-048-128476; anti-HIV_cap256-048-128270; anti-HIV_cap256-048-126220; anti-HIV_cap256-048-125713; anti-HIV_cap256-048-123934; anti-HIV_cap256-048-122673; anti-HIV_cap256-048-122208; anti-HIV_cap256-048-121552; anti-HIV_cap256-048-120643; anti-HIV_cap256-048-118458; anti-HIV_cap256-048-118112; anti-HIV_cap256-048-116469; anti-HIV_cap256-048-113917; anti-HIV_cap256-048-112368; anti-HIV_cap256-048-112047; anti-HIV_cap256-048-112029; anti-HIV_cap256-048-110957; anti-HIV_cap256-048-110526; anti-HIV_cap256-048-109336; anti-HIV_cap256-048-108152; anti-HIV_cap256-048-107799; anti-HIV_cap256-048-107384; anti-HIV_cap256-048-106530; anti-HIV_cap256-048-106464; anti-HIV_cap256-048-106411; anti-HIV_cap256-048-106306; anti-HIV_cap256-048-104496; anti-HIV_cap256-048-103074; anti-HIV_cap256-048-100832; anti-HIV_cap256-048-100188; anti-HIV_cap256-048-099645; anti-HIV_cap256-048-098137; anti-HIV_cap256-048-097878; anti-HIV_cap256-048-097510; anti-HIV_cap256-048-097313; anti-HIV_cap256-048-096626; anti-HIV_cap256-048-096483; anti-HIV_cap256-048-095691; anti-HIV_cap256-048-095525; anti-HIV_cap256-048-094783; anti-HIV_cap256-048-094356; anti-HIV_cap256-048-090756; anti-HIV_cap256-048-089065; anti-HIV_cap256-048-084986; anti-HIV_cap256-048-083355; anti-HIV_cap256-048-082462; anti-HIV_cap256-048-082246; anti-HIV_cap256-048-080752; anti-HIV_cap256-048-078409; anti-HIV_cap256-048-078273; anti-HIV_cap256-048-078062; anti-HIV_cap256-048-077798; anti-HIV_cap256-048-073853; anti-HIV_cap256-048-071661; anti-HIV_cap256-048-071360; anti-HIV_cap256-048-070955; anti-HIV_cap256-048-070061; anti-HIV_cap256-048-069669; anti-HIV_cap256-048-069205; anti-HIV_cap256-048-068882; anti-HIV_cap256-048-067764; anti-HIV_cap256-048-066845; anti-HIV_cap256-048-065226; anti-HIV_cap256-048-063717; anti-HIV_cap256-048-063150; anti-HIV_cap256-048-062431; anti-HIV_cap256-048-060745; anti-HIV_cap256-048-060420; anti-HIV_cap256-048-060014; anti-HIV_cap256-048-059747; anti-HIV_cap256-048-058393; anti-HIV_cap256-048-058159; anti-HIV_cap256-048-057127; anti-HIV_cap256-048-056251; anti-HIV_cap256-048-055421; anti-HIV_cap256-048-054989; anti-HIV_cap256-048-054759; anti-HIV_cap256-048-052573; anti-HIV_cap256-048-051477; anti-HIV_cap256-048-051299; anti-HIV_cap256-048-050815; anti-HIV_cap256-048-049884; anti-HIV_cap256-048-049170; anti-HIV_cap256-048-048531; anti-HIV_cap256-048-048259; anti-HIV_cap256-048-047313; anti-HIV_cap256-048-046596; anti-HIV_cap256-048-044781; anti-HIV_cap256-048-042599; anti-HIV_cap256-048-041276; anti-HIV_cap256-048-040200; anti-HIV_cap256-048-039061; anti-HIV_cap256-048-038515; anti-HIV_cap256-048-038255; anti-HIV_cap256-048-038177; anti-HIV_cap256-048-035513; anti-HIV_cap256-048-034112; anti-HIV_cap256-048-033983; anti-HIV_cap256-048-032688; anti-HIV_cap256-048-031092; anti-HIV_cap256-048-030464; anti-HIV_cap256-048-030289; anti-HIV_cap256-048-030261; anti-HIV_cap256-048-029362; anti-HIV_cap256-048-027638; anti-HIV_cap256-048-027613; anti-HIV_cap256-048-026627; anti-HIV_cap256-048-026239; anti-HIV_cap256-048-025518; anti-HIV_cap256-048-024854; anti-HIV_cap256-048-024537; anti-HIV_cap256-048-021781; anti-HIV_cap256-048-021758; anti-HIV_cap256-048-020988; anti-HIV_cap256-048-020663; anti-HIV_cap256-048-020590; anti-HIV_cap256-048-019765; anti-HIV_cap256-048-019254; anti-HIV_cap256-048-018073; anti-HIV_cap256-048-016775; anti-HIV_cap256-048-016069; anti-HIV_cap256-048-015867; anti-HIV_cap256-048-015673; anti-HIV_cap256-048-015156; anti-HIV_cap256-048-014521; anti-HIV_cap256-048-014475; anti-HIV_cap256-048-013798; anti-HIV_cap256-048-013271; anti-HIV_cap256-048-013180; anti-HIV_cap256-048-012148; anti-HIV_cap256-048-011870; anti-HIV_cap256-048-011530; anti-HIV_cap256-048-010968; anti-HIV_cap256-048-010224; anti-HIV_cap256-048-009749; anti-HIV_cap256-048-009623; anti-HIV_cap256-048-008234; anti-HIV_cap256-048-008149; anti-HIV_cap256-048-007301; anti-HIV_cap256-048-007174; anti-HIV_cap256-048-007079; anti-HIV_cap256-048-007033; anti-HIV_cap256-048-006128; anti-HIV_cap256-048-005999; anti-HIV_cap256-048-005394; anti-HIV_cap256-048-004226; anti-HIV_cap256-048-004097; anti-HIV_cap256-048-003289; anti-HIV_cap256-048-002601; anti-HIV_cap256-048-002129; anti-HIV_cap256-048-001875; anti-HIV_cap256-048-001302; anti-HIV_cap256-048-001203; anti-HIV_cap256-048-000383; anti-HIV_cap256-038-261791; anti-HIV_cap256-038-241540; anti-HIV_cap256-038-235677; anti-HIV_cap256-038-234314; anti-HIV_cap256-038-234273; anti-HIV_cap256-038-223164; anti-HIV_cap256-038-220289; anti-HIV_cap256-038-220020; anti-HIV_cap256-038-216853; anti-HIV_cap256-038-213466; anti-HIV_cap256-038-213212; anti-HIV_cap256-038-213120; anti-HIV_cap256-038-212592; anti-HIV_cap256-038-211790; anti-HIV_cap256-038-209916; anti-HIV_cap256-038-207938; anti-HIV_cap256-038-202245; anti-HIV_cap256-038-197721; anti-HIV_cap256-038-196679; anti-HIV_cap256-038-196118; anti-HIV_cap256-038-195382; anti-HIV_cap256-038-180001; anti-HIV_cap256-038-178021; anti-HIV_cap256-038-177104; anti-HIV_cap256-038-171261; anti-HIV_cap256-038-169090; anti-HIV_cap256-038-168705; anti-HIV_cap256-038-167685; anti-HIV_cap256-038-158775; anti-HIV_cap256-038-157318; anti-HIV_cap256-038-153058; anti-HIV_cap256-038-150027; anti-HIV_cap256-038-146372; anti-HIV_cap256-038-141868; anti-HIV_cap256-038-141616; anti-HIV_cap256-038-127989; anti-HIV_cap256-038-118109; anti-HIV_cap256-038-112226; anti-HIV_cap256-038-105918; anti-HIV_cap256-038-104487; anti-HIV_cap256-038-102308; anti-HIV_cap256-038-091115; anti-HIV_cap256-038-090262; anti-HIV_cap256-038-083260; anti-HIV_cap256-038-080981; anti-HIV_cap256-038-080873; anti-HIV_cap256-038-074413; anti-HIV_cap256-038-073153; anti-HIV_cap256-038-064227; anti-HIV_cap256-038-061640; anti-HIV_cap256-038-059482; anti-HIV_cap256-038-054000; anti-HIV_cap256-038-050554; anti-HIV_cap256-038-044256; anti-HIV_cap256-038-040944; anti-HIV_cap256-038-040090; anti-HIV_cap256-038-032874; anti-HIV_cap256-038-025899; anti-HIV_cap256-038-024581; anti-HIV_cap256-038-013345; anti-HIV_cap256-038-011559; anti-HIV_cap256-038-009634; anti-HIV_cap256-038-006730; anti-HIV_cap256-038-004887; anti-HIV_cap256-038-004840; anti-HIV_cap256-038-002181; anti-HIV_cap256-038-001902; anti-HIV_cap256-038-000976; anti-HIV_cap256-038-000384; anti-HIV_206-314431; anti-HIV_206-247594; anti-HIV_206-116890; anti-HIV_206-072383; anti-HIV_206-037527; anti-HIV_206-009095; anti-HIV_176-503620; anti-HIV_176-478726; anti-HIV_276-245056; anti-HIV_176-164413; anti-HIV_176-094308; anti-HIV_176-065321; anti-HIV_119-099719; anti-HIV_119-099536; anti-HIV_119-098907; anti-HIV_119-098555; anti-HIV_119-097828; anti-HIV_119-096480; anti-HIV_119-095664; anti-HIV_119-095212; anti-HIV_119-094773; anti-HIV_119-094508; anti-HIV_119-093795; anti-HIV_119-093732; anti-HIV_119-092903; anti-HIV_119-092284; anti-HIV_119-091586; anti-HIV_119-091023; anti-HIV_119-090334; anti-HIV_119-088694; anti-HIV_119-088499; anti-HIV_119-088298; anti-HIV_119-087488; anti-HIV_119-087423; anti-HIV_119-087371; anti-HIV_119-087279; anti-HIV_119-087146; anti-HIV_119-087048; anti-HIV_119-085802; anti-HIV_119-085784; anti-HIV_119-085370; anti-HIV_119-085276; anti-HIV_119-084885; anti-HIV_119-084874; anti-HIV_119-084691; anti-HIV_119-083793; anti-HIV_119-083163; anti-HIV_119-082331; anti-HIV_119-082070; anti-HIV_119-081512; anti-HIV_119-080816; anti-HIV_119-079302; anti-HIV_119-079292; anti-HIV_119-079289; anti-HIV_119-078935; anti-HIV_119-078702; anti-HIV_119-078593; anti-HIV_119-077708; anti-HIV_119-076904; anti-HIV_119-075862; anti-HIV_119-075465; anti-HIV_119-074822; anti-HIV_119-074629; anti-HIV_119-074500; anti-HIV_119-073911; anti-HIV_119-072765; anti-HIV_119-072313; anti-HIV_119-072280; anti-HIV_119-071693; anti-HIV_119-071353; anti-HIV_119-069711; anti-HIV_119-069061; anti-HIV_119-068202; anti-HIV_119-068063; anti-HIV_119-067980; anti-HIV_119-067866; anti-HIV_119-067756; anti-HIV_119-066859; anti-HIV_119-065821; anti-HIV_119-065191; anti-HIV_119-064667; anti-HIV_119-063791; anti-HIV_119-062989; anti-HIV_119-062286; anti-HIV_119-061416; anti-HIV_119-061344; anti-HIV_119-060240; anti-HIV_119-060184; anti-HIV_119-058035; anti-HIV_119-057858; anti-HIV_119-057473; anti-HIV_119-057090; anti-HIV_119-055754; anti-HIV_119-054899; anti-HIV_119-054501; anti-HIV_119-051867; anti-HIV_119-051814; anti-HIV_119-051567; anti-HIV_119-051483; anti-HIV_119-050913; anti-HIV_119-050187; anti-HIV_119-049069; anti-HIV_119-048517; anti-HIV_119-048470; anti-HIV_119-048303; anti-HIV_119-048021; anti-HIV_119-047928; anti-HIV_119-047384; anti-HIV_119-047145; anti-HIV_119-046752; anti-HIV_119-046660; anti-HIV_119-046202; anti-HIV_119-045790; anti-HIV_119-044670; anti-HIV_119-044140; anti-HIV_119-042776; anti-HIV_119-042581; anti-HIV_119-040905; anti-HIV_119-040322; anti-HIV_119-039892; anti-HIV_119-039764; anti-HIV_119-039188; anti-HIV_119-039058; anti-HIV_119-038837; anti-HIV_119-038396; anti-HIV_119-036918; anti-HIV_119-036592; anti-HIV_119-036310; anti-HIV_119-035618; anti-HIV_119-035569; anti-HIV_119-035466; anti-HIV_119-035157; anti-HIV_119-035121; anti-HIV_119-035046; anti-HIV_119-034754; anti-HIV_119-034318; anti-HIV_119-033780; anti-HIV_119-033632; anti-HIV_119-033183; anti-HIV_119-030696; anti-HIV_119-030059; anti-HIV_119-029589; anti-HIV_119-029448; anti-HIV_119-029220; anti-HIV_119-028317; anti-HIV_119-028165; anti-HIV_119-027147; anti-HIV_119-026743; anti-HIV_119-026508; anti-HIV_119-025683; anti-HIV_119-025614; anti-HIV_119-025548; anti-HIV_119-025526; anti-HIV_119-023552; anti-HIV_119-023092; anti-HIV_119-022793; anti-HIV_119-022395; anti-HIV_119-022334; anti-HIV_119-021866; anti-HIV_119-021278; anti-HIV_119-021183; anti-HIV_119-019376; anti-HIV_119-019238; anti-HIV_119-018500; anti-HIV_119-018318; anti-HIV_119-018218; anti-HIV_119-017876; anti-HIV_119-017740; anti-HIV_119-017128; anti-HIV_119-017044; anti-HIV_119-016644; anti-HIV_119-015878; anti-HIV_119-015538; anti-HIV_119-015455; anti-HIV_119-014425; anti-HIV_119-013582; anti-HIV_119-013364; anti-HIV_119-012886; anti-HIV_119-012249; anti-HIV_119-012161; anti-HIV_119-012110; anti-HIV_119-012100; anti-HIV_119-011651; anti-HIV_119-011479; anti-HIV_119-011232; anti-HIV_119-011175; anti-HIV_119-008396; anti-HIV_119-007148; anti-HIV_119-007029; anti-HIV_119-004707; anti-HIV_119-003910; anti-HIV_119-002450; anti-HIV_119-001552; anti-HIV_059-188169; anti-HIV_059-183739; anti-HIV_059-182376; anti-HIV_059-182199; anti-HIV_059-169202; anti-HIV_059-155645; anti-HIV_059-151619; anti-HIV_059-146503; anti-HIV_059-136098; anti-HIV_059-105516; anti-HIV_059-095709; anti-HIV_059-069468; anti-HIV_059-060026; anti-HIV_059-053668; anti-HIV_059-052864; anti-HIV_059-050968; anti-HIV_059-046422; anti-HIV_059-045120; anti-HIV_059-039932; anti-HIV_059-038595; anti-HIV_059-035082; anti-HIV_059-029204; anti-HIV_059-025235; anti-HIV_059-015192; anti-HIV_059-007060; anti-HIV_059-006953; anti-HIV_059-005953; anti-HIV_059-003725; anti-HIV_059-002618; anti-HIV_059-001522; anti-HIV_059-000731; anti-HIV_059-000634; anti-HIV_048-250757; anti-HIV_048-250716; anti-HIV_048-250463; anti-HIV_048-248153; anti-HIV_048-247532; anti-HIV_048-245846; anti-HIV_048-244016; anti-HIV_048-243682; anti-HIV_048-243588; anti-HIV_048-241775; anti-HIV_048-237996; anti-HIV_048-237730; anti-HIV_048-237253; anti-HIV_048-234100; anti-HIV_048-230882; anti-HIV_048-229473; anti-HIV_048-228238; anti-HIV_048-228027; anti-HIV_048-227795; anti-HIV_048-227770; anti-HIV_048-225298; anti-HIV_048-225090; anti-HIV_048-224187; anti-HIV_048-223055; anti-HIV_048-222711; anti-HIV_048-221209; anti-HIV_048-220629; anti-HIV_048-219430; anti-HIV_048-216250; anti-HIV_048-216133; anti-HIV_048-214886; anti-HIV_048-214709; anti-HIV_048-214001; anti-HIV_048-213230; anti-HIV_048-212574; anti-HIV_048-212207; anti-HIV_048-209146; anti-HIV_048-208206; anti-HIV_048-208194; anti-HIV_048-207744; anti-HIV_048-206501; anti-HIV_048-204221; anti-HIV_048-204015; anti-HIV_048-201240; anti-HIV_048-200455; anti-HIV_048-200319; anti-HIV_048-197896; anti-HIV_048-193813; anti-HIV_048-192098; anti-HIV_048-191786; anti-HIV_048-188746; anti-HIV_048-185937; anti-HIV_048-184849; anti-HIV_048-183089; anti-HIV_048-181509; anti-HIV_048-180990; anti-HIV_048-177532; anti-HIV_048-177426; anti-HIV_048-177389; anti-HIV_048-174266; anti-HIV_048-172847; anti-HIV_048-172845; anti-HIV_048-172363; anti-HIV_048-171609; anti-HIV_048-170705; anti-HIV_048-168381; anti-HIV_048-166619; anti-HIV_048-162036; anti-HIV_048-160042; anti-HIV_048-159676; anti-HIV_048-159500; anti-HIV_048-159421; anti-HIV_048-159333; anti-HIV_048-158932; anti-HIV_048-155811; anti-HIV_048-155464; anti-HIV_048-155392; anti-HIV_048-155389; anti-HIV_048-154449; anti-HIV_048-153379; anti-HIV_048-153171; anti-HIV_048-152324; anti-HIV_048-146102; anti-HIV_048-145984; anti-HIV_048-145371; anti-HIV_048-144907; anti-HIV_048-142298; anti-HIV_048-142277; anti-HIV_048-141934; anti-HIV_048-141207; anti-HIV_048-140796; anti-HIV_048-139893; anti-HIV_048-138820; anti-HIV_048-135858; anti-HIV_048-134968; anti-HIV_048-134312; anti-HIV_048-132253; anti-HIV_048-130710; anti-HIV_048-128564; anti-HIV_048-126702; anti-HIV_048-124521; anti-HIV_048-122740; anti-HIV_048-119536; anti-HIV_048-116929; anti-HIV_048-116577; anti-HIV_048-116046; anti-HIV_048-115875; anti-HIV_048-115599; anti-HIV_048-113988; anti-HIV_048-112989; anti-HIV_048-112435; anti-HIV_048-111339; anti-HIV_048-111055; anti-HIV_048-111027; anti-HIV_048-109721; anti-HIV_048-109666; anti-HIV_048-109196; anti-HIV_048-109051; anti-HIV_048-108570; anti-HIV_048-108033; anti-HIV_048-107279; anti-HIV_048-106271; anti-HIV_048-106054; anti-HIV_048-104848; anti-HIV_048-104638; anti-HIV_048-104567; anti-HIV_048-102804; anti-HIV_048-101676; anti-HIV_048-097603; anti-HIV_048-097107; anti-HIV_048-096871; anti-HIV_048-096668; anti-HIV_048-095236; anti-HIV_048-094155; anti-HIV_048-093219; anti-HIV_048-092976; anti-HIV_048-090866; anti-HIV_048-090650; anti-HIV_048-089009; anti-HIV_048-088654; anti-HIV_048-086513; anti-HIV_048-086024; anti-HIV_048-085857; anti-HIV_048-084277; anti-HIV_048-084245; anti-HIV_048-082487; anti-HIV_048-081787; anti-HIV_048-081062; anti-HIV_048-079639; anti-HIV_048-079126; anti-HIV_048-073118; anti-HIV_048-070264; anti-HIV_048-069426; anti-HIV_048-068564; anti-HIV_048-068345; anti-HIV_048-067337; anti-HIV_048-067180; anti-HIV_048-063017; anti-HIV_048-061885; anti-HIV_048-061671; anti-HIV_048-060700; anti-HIV_048-060592; anti-HIV_048-060300; anti-HIV_048-059141; anti-HIV_048-057777; anti-HIV_048-056928; anti-HIV_048-056131; anti-HIV_048-055864; anti-HIV_048-055094; anti-HIV_048-054343; anti-HIV_048-054193; anti-HIV_048-052521; anti-HIV_048-049037; anti-HIV_048-048720; anti-HIV_048-048542; anti-HIV_048-047777; anti-HIV_048-046841; anti-HIV_048-046202; anti-HIV_048-046059; anti-HIV_048-043568; anti-HIV_048-042713; anti-HIV_048-042440; anti-HIV_048-040511; anti-HIV_048-039195; anti-HIV_048-036935; anti-HIV_048-034478; anti-HIV_048-031641; anti-HIV_048-029760; anti-HIV_048-027970; anti-HIV_048-027337; anti-HIV_048-027217; anti-HIV_048-026760; anti-HIV_048-024800; anti-HIV_048-024313; anti-HIV_048-021748; anti-HIV_048-020991; anti-HIV_048-020340; anti-HIV_048-019993; anti-HIV_048-019947; anti-HIV_048-017871; anti-HIV_048-015931; anti-HIV_048-015920; anti-HIV_048-013898; anti-HIV_048-013429; anti-HIV_048-012358; anti-HIV_048-011158; anti-HIV_048-010720; anti-HIV_048-009445; anti-HIV_048-006126; anti-HIV_048-005652; anti-HIV_048-005532; anti-HIV_048-005189; anti-HIV_048-005088; anti-HIV_048-004023; anti-HIV_048-001580; anti-HIV_038-221120; anti-HIV_038-197677; anti-HIV_038-196765; anti-HIV_038-186200; anti-HIV_038-126170; anti-HIV_038-108545; anti-HIV_038-107263; anti-HIV_038-104530; anti-HIV_038-099169; anti-HIV_038-075067; anti-HIV_038-072368; anti-HIV_038-068503; anti-HIV_038-068016; anti-HIV_038-063958; anti-HIV_038-033733; anti-HIV_038-030557; anti-HIV_038-024298; anti-HIV_038-011154; anti-HIV_5CIN; anti-HIV_5CIL; anti-HIV_5CIP; anti-HIV_4JKP; anti-HIV_3TNN; anti-HIV_3BQU; anti-HIV_IgG; anti-HIV_4P9M; anti-HIV_4P9H; anti-HIV_Ig; anti-HIV; anti-influenza; anti-influenza_Apo; anti-influenza-A; anti-OX40.

Preferably, the antibody or the fragment of variant thereof, which is encoded by the at least one coding sequence of the RNA according to the present invention, is selected from the group consisting of antibodies having an amino acid sequence according to any of the amino acid sequences SEQ ID NO: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, 61730 or a fragment or variant of any one of said amino acid sequences.

The at least one coding sequence of the RNA according to the invention preferably comprises a nucleic acid sequence encoding a full-length antibody or a full-length variant of an antibody as defined herein. The term ‘full-length antibody’ or ‘full-length variant of an antibody’ as used herein typically refers to an antibody that substantially comprises the entire amino acid sequence of the antibody. For example, the RNA preferably comprises a nucleic acid sequence encoding all chains of the antibody, in particular if the antibody comprises more than one chain (a “multiple-chain antibody”).

It is also preferred that the at least one coding sequence of the RNA according to the invention comprises a nucleic acid sequence encoding a fragment of an antibody. In the context of the present invention, a ‘fragment’ of an antibody or of a variant thereof may comprise a sequence of an antibody or of a variant thereof as defined herein, which is, with regard to its amino acid sequence (or its encoded nucleic acid sequence), N-terminally, C-terminally and/or intrasequentially truncated compared to the amino acid sequence of the full-length antibody or a variant thereof (or its encoded nucleic acid sequence). Such truncation may thus occur either on the amino acid level or on the nucleic acid level, respectively. A sequence identity with respect to such a fragment as defined herein therefore preferably refers to the entire antibody or a variant thereof as defined herein or to the entire (coding) nucleic acid sequence of such an antibody or of a variant thereof.

Preferably, a fragment or a variant of an antibody is a functional fragment or a functional variant, which comprises at least one functional CDR of the corresponding antibody capable of recognizing (and binding to) an antigen.

Such a fragment has preferably a length of at least 3 amino acids. More preferably, such a fragment has a length of at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 amino acids.

Examples of such antibody fragments are any antibody fragments known to a person skilled in the art, e.g. Fab, Fab′, F(ab′)₂, Fc, Facb, pFc′, Fd, and Fv fragments of the abovementioned antibodies etc. A diagram of the structure of such exemplified antibody fragments is shown by way of example in FIG. 4. For example, a Fab (fragment antigen binding) fragment typically comprises the variable and a constant domain of a light and a heavy chain, e.g. the C_(H)1 and the V_(H) domain of the heavy chain and the complete light chain. The two chains are bonded to one another via a disulfide bridge. A Fab fragment thus conventionally contains the complete antigen-binding region of the original antibody and usually has the same affinity for the antigen, the immunogen or an epitope of a protein. Antibody fragments, as also described above for antibodies, can be prepared with the aid of molecular biology methods. In this context, the DNA sequences which code for the various domains of the antibody fragment are cloned into a specific expression vector. The RNA which codes for these antibody fragments can then be expressed e.g. in suitable host cells. Suitable host cells in connection with the present invention include, inter alia, E. coli, yeasts, transgenic plants or mammalian cells etc. (see below). Moreover, antibody fragments consisting of the minimal binding subunit of antibodies are known as single-chain antibodies (scFvs) and have excellent binding specificity and affinity for their ligands. An scFv fragment (single chain variable fragment) typically comprises the variable domain of the light and of the heavy chain, which are bonded to one another via an artificial polypeptide linker. In the cloning of such scFv fragments, RNAs which code for a V_(H) and V_(L), these being linked to one another by a polypeptide linker, are preferably provided. As a rule, a polypeptide built up from 15-25 glycine, proline and/or serine residues (cf. FIG. 5) or the associated nucleotide sequence is used at the RNA level for the provision of this component.

Preferably, the antibody fragment, which is encoded by the coding sequence of the RNA according to the invention, is an antigen-binding fragment. Such an antigen-binding fragment typically comprises at least one CDR. More preferably, the antibody fragment, which is encoded by the coding sequence of the RNA according to the invention, comprises a heavy chain variable region (V_(H)) and/or a light chain variable region (V_(L)). Even more preferably, the antibody fragment, which is encoded by the coding sequence of the RNA according to the invention, comprises a complete (full-length) heavy chain or a complete (full-length) light chain of an antibody.

It is also preferred that the RNA comprises at least one coding sequence encoding a variant of an antibody as defined herein, or a fragment of a variant of an antibody. Preferably, such variants have the same biological function as or, respectively, the specific activity of the corresponding full length antibody or of the corresponding antibody fragment, e.g. the specific binding of particular antigens or nucleic acids. Accordingly, it is preferred, if the hypervariable region(s) are conserved or are modified by merely conservative mutations.

The biological function of antibodies described here which are coded by the RNA according to the invention includes e.g. neutralization of antigens, complement activation or opsonization. In the case of neutralization of antigens, the antibody can bind to an antigen and thereby neutralize this. The antibody is conventionally blocked by the binding of the antigen, and can therefore display its action only against one antigen, or two antigens in the case of bispecific antibodies. scFv antibody fragments are suitable above all for this (neutralization) function of an antibody, since they do not include the functions of the constant domains of an antibody. In the case of complement activation, the complex system of complement proteins which are dependent upon the Fc part of the antibody can be activated via binding of antibodies. End products of the complement cascade typically lead to lysis of cells and to the creation of a phlogistic (inflammatory) milieu. In the case of opsonization, pathogens or foreign particles are rendered accessible to phagocytes by binding by an antibody via the constant domains of the antibody. Alternatively, the opsonized cells, which are recognized as foreign, can be lysed via an antibody-dependent, cell-mediated cytotoxicity (ADCC). In this context, NK cells in particular can perform lytic functions in this manner via activation of their Fc receptors.

In certain embodiments of the present invention, a ‘variant’ of an antibody or a fragment thereof as defined herein may be encoded by the RNA comprising at least one coding sequence as defined herein, wherein the amino acid sequence encoded by the at least one coding sequence differs in at least one amino acid residue from the antibody's reference amino acid sequence. Exemplified reference amino acid sequences of antibodies are shown below in Table 3.

In this context, the ‘change’ in at least one amino acid residue may consist, for example, in a mutation of an amino acid residue to another amino acid, a deletion or an insertion. More preferably, the term ‘variant’ as used in the context of the amino acid sequence encoded by the at least one coding sequence of the RNA according to the invention comprises any homolog, isoform or transcript variant of the antibody or a fragment thereof as defined herein, wherein the homolog, isoform or transcript variant is preferably characterized by a degree of identity or homology, respectively, as defined herein.

Preferably, a variant of an antibody or a fragment thereof may be encoded by the RNA comprising at least one coding sequence as defined herein, wherein at least one amino acid residue of the amino acid sequence encoded by the at least one coding sequence is substituted. Substitutions, wherein amino acids, which originate from the same class, are exchanged for one another, are called conservative substitutions. In particular, these are amino acids having aliphatic side chains, positively or negatively charged side chains, aromatic groups in the side chains or amino acids, the side chains of which can form hydrogen bridges, e.g. side chains which have a hydroxyl function. By conservative constitution, e.g. an amino acid having a polar side chain may be replaced by another amino acid having a corresponding polar side chain, or, for example, an amino acid characterized by a hydrophobic side chain may be substituted by another amino acid having a corresponding hydrophobic side chain (e.g. serine (threonine) by threonine (serine) or leucine (isoleucine) by isoleucine (leucine)). In a preferred embodiment, a variant of an antibody or a fragment thereof may be encoded by the RNA according to the invention, wherein at least one amino acid residue of the amino acid sequence encoded by the at least one coding sequence comprises at least one conservative substitution compared to the respective reference sequence. These amino acid sequences as well as their encoding nucleic acid sequences in particular are comprised by the term ‘variant’ as defined herein.

Insertions, deletions and/or non-conservative substitutions are also possible, in particular, at those sequence positions, which cause no modification to the three-dimensional structure or do not affect the binding region. Modifications to a three-dimensional structure by insertion(s) or deletion(s) can easily be determined e.g. using CD spectra (circular dichroism spectra) (Urry, 1985, Absorption, Circular Dichroism and ORD of Polypeptides, in: Modern Physical Methods in Biochemistry, Neuberger et al. (ed.), Elsevier, Amsterdam).

In order to determine the percentage, to which two sequences (nucleic acid sequences, e.g. RNA or mRNA sequences as defined herein, or amino acid sequences, preferably the amino acid sequence encoded by the RNA according to the invention) are identical, the sequences can be aligned in order to be subsequently compared to one another. For this purpose, e.g. gaps can be inserted into the sequence of the first sequence and the component at the corresponding position of the second sequence can be compared. If a position in the first sequence is occupied by the same component as is the case at a corresponding position in the second sequence, the two sequences are identical at this position. The percentage, to which two sequences are identical, is a function of the number of identical positions divided by the total number of positions. The percentage, to which two sequences are identical, can be determined using a mathematical algorithm. A preferred, but not limiting, example of a mathematical algorithm, which can be used is the algorithm of Karlin et al. (1993), PNAS USA, 90:5873-5877 or Altschul et al. (1997), Nucleic Acids Res., 25:3389-3402. Such an algorithm is integrated, for example, in the BLAST program. Sequences, which are identical to the sequences of the present invention to a certain extent, can be identified by this program. Typically, “% sequence identity” is calculated in respect to a reference sequence. Exemplified reference sequences in the context of the present invention are the sequences according to SEQ ID NO: 1-61734, in particular the protein and RNA sequences shown in Table 3 below.

A fragment of an antibody or a variant thereof encoded by the at least one coding sequence of the RNA according to the invention may typically comprise an amino acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with an amino acid sequence of the respective reference full-length antibody or a fragment thereof.

More preferably, a fragment of an antibody or a variant thereof encoded by the at least one coding sequence of the RNA according to the invention may typically comprise or consist of an amino acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, 61730; or a fragment or variant of any one of said amino acid sequences.

Most preferably, a fragment of an antibody or a variant thereof encoded by the at least one coding sequence of the RNA according to the invention typically comprises or consists of an amino acid sequence having a sequence identity of at least 80% with an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, 61730; or a fragment or variant of any one of said amino acid sequences.

Without being limited thereto, according to the present invention RNAs which code for antibodies inter alia code for those antibodies which bind antigens or specific nucleic acids. Antigens in the context of the present invention are typically molecules which are recognized as exogenous by the immune system and conventionally cause an immune reaction or immune response with the formation of antibodies directed specifically against them. However, antigens can also include, especially in the case of autoimmune diseases, endogenous molecules or structures which are incorrectly recognized as exogenous by the immune system and thereby trigger an immune reaction. Alternatively formulated, antigens are therefore all molecules which are recognized by an antibody in the context of the present invention. Antigens substantially comprise proteins, peptides or epitopes of these proteins or peptides. In this context, epitopes (also called “antigenic determinants”) are typically small regions (molecular sections) lying on the surface of such protein or peptide structures and having a length of from 5 to 15, in rare case also to 25, preferably 6 to 9 amino acids. Antigens can furthermore also include lipids, carbohydrates etc. In the context of the present invention, antigens also include, for example, so-called immunogens, i.e. antigens which lead to an immunity of the organism transfected therewith. Antigens by way of example include, without being limited thereto, surface antigens of cells, tumour antigens etc. For example, according to the present invention antibodies can bind the following antigens (which typically occur in vertebrates), e.g. tumour-specific surface antigens (TSSA), e.g. 5T4, α5β1-integrin, 707-AP, AFP, ART-4, B7H4, BAGE, β-catenin/m, Bcr-abl, MN/C IX-antigen, CA125, CAMEL, CAP-1, CASP-8, CD4, CD19, CD20, CD22, CD25, CDC27/m, CD 30, CD33, CD52, CD56, CD80, CDK4/m, CEA, CT, Cyp-B, DAM, EGFR, ErbB3, ELF2M, EMMPRIN, EpCam, ETV6-AML1, G250, GAGE, GnT-V, Gp100, HAGE, HER-2/neu, HLA-A*0201-R170I, HPV-E7, HSP70-2M, HAST-2, hTERT (or hTRT), iCE, IGF-1R, IL-2R, IL-5, KIAA0205, LAGE, LDLR/FUT, MAGE, MART-1/Melan-A, MART-2/Ski, MC1R, myosin/m, MUC1, MUM-1, -2, -3, NA88-A, NY-ESO1, PAP, proteinase-3, p190 minor bcr-abl, Pml/RARα, PRAME, PSA, PSM, PSMA, RAGE, RU1 or RU2, SAGE, SART-1 or SART-3, survivin, TEL/AML1, TGFβ, TPI/m, TRP-1, TRP-2, TRP-2/INT2, VEGF and WT1, or sequences, such as e.g. NY-Eso-1 or NY-Eso-B. Tumour antigens can, for example, typically be responsible for metastasing, that is to say dissolving of tumour cells out of their native tissue, transfer into the vascular system (lymph or blood vessel system), exit from the vascular system and colonization in a new tissue. In this context, such tumour antigens which cause modified cell-cell interactions compared with the native state are of interest in particular.

Antibodies encoded by the inventive RNA may also be directed against tumour antigens listed by Table 1 or Table 2. In particular, RNA encoding those antibodies may be used to treat (or, may be used to prepare a medicament to treat, respectively) the cancer diseases given in the last column of Tables 1 and 2.

TABLE 1 Antigens expressed in cancer diseases Tumor antigen Name of tumor antigen Cancers or cancer diseases related thereto 5T4 colorectal cancer, gastric cancer, ovarian cancer 707-AP 707 alanine proline melanoma 9D7 renal cell carcinoma AFP alpha-fetoprotein hepatocellular carcinoma, gallbladder cancer, testicular cancer, ovarian cancer, bladder cancer AlbZIP HPG1 prostate cancer alpha5beta1-Integrin alpha5beta6-Integrin colon cancer alpha-methylacyl-coenzyme prostate cancer A racemase ART-4 adenocarcinoma antigen lung cancer, head and neck cancer, leukemia, esophageal recognized by T cells 4 cancer, gastric cancer, cervical cancer, ovarian cancer, breast cancer, squamous cell carcinoma B7H4 ovarian cancer BAGE-1 B antigen bladder cancer, head and neck cancer, lung cancer, melanoma, squamous cell carcinoma BCL-2 leukemia BING-4 melanoma CA 15-3/CA 27-29 breast cancer, ovary cancer, lung cancer, prostate cancer CA 19-9 gastric cancer, pancreatic cancer, liver cancer, breast cancer, gallbladder cancer, colon cancer, ovary cancer, lung cancer CA 72-4 ovarian cancer CA125 ovarian cancer, colorectal cancer, gastric cancer, liver cancer, pancreatic cancer, uterus cancer, cervix carcinoma, colon cancer, breast cancer, lung cancer calreticulin bladder cancer CAMEL CTL-recognized antigen on melanoma melanoma CASP-8 caspase-B head and neck cancer cathepsin B breast cancer cathepsin L breast cancer CD19 B-cell malignancies CD20 CD22 CD25 CD30 CD33 CD4 CD52 CD55 CD56 CD80 CEA carcinoembryonic antigen gut carcinoma, colorectal cancer, colon cancer, hepatocellular cancer, lung cancer, breast cancer, thyroid cancer, pancreatic cancer, liver cancer cervix cancer, bladder cancer, melanoma CLCA2 calcium-activated chloride channel-2 lung cancer CML2B leukemia Coactosin-like protein pancreatic cancer Collagen XXIII prostate cancer COX-2 ovarian cancer, breast cancer, colorectal cancer CT-9/BRD6 bromodomain testis-specific protein Cten C-terminal tensin-like protein prostate cancer cyclin B1 cyclin D1 ovarian cancer cyp-B cyclophilin B bladder cancer, lung cancer, T-cell leukemia, squamous cell carcinoma, CYPB1 cytochrom P450 1B1 leukemia DAM-10/MAGE-B1 differentiation antigen melanoma 10 melanoma, skin tumors, ovarian cancer, lung cancer DAM-6/MAGE-B2 differentiation antigen melanoma 6 melanoma, skin tumors, ovarian cancer, lung cancer EGFR/Her1 lung cancer, ovarian cancer, head and neck cancer, colon cancer, pancreatic cancer, breast cancer EMMPRIN tumor cell-associated extracellular lung cancer, breast cancer, bladder cancer, ovarian cancer, matrix metalloproteinase inducer/ brain cancer, lymphoma EpCam epithelial cell adhesion molecule ovarian cancer, breast cancer, colon cancer, lung cancer EphA2 ephrin type-A receptor 2 glioma EphA3 ephrin type-A receptor 2 melanoma, sarcoma, lung cancer ErbB3 breast cancer EZH2 (enhancer of Zeste homolog 2) endometrium cancer, melanoma, prostate cancer, breast cancer FGF-5 fibroblast growth factor-5 renal cell carcinoma, breast cancer, prostate cancer FN fibronectin melanoma Fra-1 Fos-related antigen-1 breast cancer, esophageal cancer, renal cell carcinoma, thyroid cancer G250/CAIX glycoprotein 250 leukemia, renal cell carcinoma, head and neck cancer, colon cancer, ovarian cancer, cervical cancer GAGE-1 G antigen 1 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-2 G antigen 2 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-3 G antigen 3 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-4 G antigen 4 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-5 G antigen 5 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-6 G antigen 6 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-7b G antigen 7b bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GAGE-8 G antigen 8 bladder cancer, lung cancer, sarcoma, melanoma, head and neck cancer GDEP gene differentially expressed in prostate prostate cancer GnT-V N-acetylglucosaminyltransferase V glioma, melanoma gp100 glycoprotein 100 kDa melanoma GPC3 glypican 3 hepatocellular carcinoma, melanoma HAGE helicase antigen bladder cancer HAST-2 human signet ring tumor-2 hepsin prostate Her2/neu/ErbB2 human epidermal receptor-2/ breast cancer, bladder cancer, melanoma, ovarian cancer, neurological pancreas cancer, gastric cancer HERV-K-MEL melanoma HNE human neutrophil elastase leukemia homeobox NKX 3.1 prostate cancer HOM-TES-14/SCP-1 ovarian cancer HOM-TES-85 HPV-E6 cervical cancer HPV-E7 cervical cancer HST-2 gastric cancer hTERT human telomerase reverse transcriptase breast cancer, melanoma, lung cancer, ovarian cancer, sarcoma, Non-Hodgkin-lymphoma, acute leukemia iCE intestinal carboxyl esterase renal cell carcinoma IGF-1R colorectal cancer IL-13Ra2 interleukin 13 receptor alpha 2 chain glioblastoma IL-2R colorectal cancer IL-5 immature laminin receptor renal cell carcinoma kallikrein 2 prostate cancer kallikrein 4 prostate cancer Ki67 prostate cancer, breast cancer, Non-Hodgkin-lymphoma, melanoma KIAA0205 bladder cancer KK-LC-1 Kita-kyushu lung cancer antigen 1 lung cancer KM-HN-1 tongue cancer, hepatocellular carcinomas, melanoma, gastric cancer, esophageal, colon cancer, pancreatic cancer LAGE-1 L antigen bladder cancer, head and neck cancer, melanoma livin bladder cancer, melanoma MAGE-A1 melanoma antigen-A1 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A10 melanoma antigen-A10 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A12 melanoma antigen-A12 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia, prostate cancer, myeloma, brain tumors MAGE-A2 melanoma antigen-A2 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A3 melanoma antigen-A3 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A4 melanoma antigen-A4 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A6 melanoma antigen-A6 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-A9 melanoma-antigen-A9 bladder cancer, head and neck cancer, melanoma, colon cancer, lung cancer, sarcoma, leukemia MAGE-B1 melanoma-antigen-B1 melanoma MAGE-B10 melanoma-antigen-B10 melanoma MAGE-B16 melanoma-antigen-B16 melanoma MAGE-B17 melanoma-antigen-B17 melanoma MAGE-B2 melanoma-antigen-B2 melanoma MAGE-B3 melanoma-antigen-B3 melanoma MAGE-B4 melanoma-antigen-B4 melanoma MAGE-B5 melanoma-antigen-B5 melanoma MAGE-B6 melanoma-antigen-B6 melanoma MAGE-C1 melanoma-antigen-C1 bladder cancer, melanoma MAGE-C2 melanoma-antigen-C2 melanoma MAGE-C3 melanoma-antigen-C3 melanoma MAGE-D1 melanoma-antigen-D1 melanoma MAGE-D2 melanoma-antigen-D2 melanoma MAGE-D4 melanoma-antigen-D4 melanoma MAGE-E1 melanoma-antigen-E1 bladder cancer, melanoma MAGE-E2 melanoma-antigen-E2 melanoma MAGE-F1 melanoma-antigen-F1 melanoma MAGE-H1 melanoma-antigen-H1 melanoma MAGEL2 MAGE-like 2 melanoma mammaglobin A breast cancer MART-1/Melan-A melanoma antigen recognized by melanoma T cells-1/melanoma antigen A MART-2 melanoma antigen recognized by melanoma T cells-2 matrix protein 22 bladder cancer MCIR melanocortin I receptor melanoma M-CSF macrophage colony-stimulating ovarian cancer factor gene mesothelin ovarian cancer MG5D/PXDN breast cancer, glioblastoma, melanoma MMP 11 M-phase phosphoprotein 11 leukemia MN/CA IX-antigen renal cell carcinoma MRP-3 multidrug resistance-associated lung cancer protein 3 MUC1 mucin 1 breast cancer MUC2 mucin 2 breast cancer, ovarian cancer, pancreatic cancer NA 88-A NA cDNA clone of patient M88 melanoma N-acetylglucosaminyltransferase-V Neo-PAP Neo-poly(A) polymerase NGEP prostate cancer NMP22 bladder cancer NPM/ALK nucleophosmin/anaplastic lymphoma kinase fusion protein NSE neuron-specific enolase small cell cancer of lung, neuroblastoma, Wilm' tumor, melanoma, thyroid cancer, kidney cancer, testicle cancer, pancreas cancer NY-ESO-1 New York esophageous 1 bladder cancer, head and neck cancer, melanoma, sarcoma, B-lymphoma, hepatoma, pancreatic cancer, ovarian cancer, breast cancer NY-ESO-B OA1 ocular albinism type 1 protein melanoma OFA-iLRP oncofetal antigen-immature leukemia laminin receptor OGT O-linked N-acetylglucosamine transferase gene OS-9 osteocalcin prostate cancer osteopontin prostate cancer, breast cancer, ovarian cancer p15 protein 15 p15 melanoma p190 minor bcr-abl p53 PAGE-4 prostate GAGE-like protein-4 prostate cancer PAI-1 plasminogen acitvator inhibitor 1 breast cancer PAI-2 plasminogen acitvator inhibitor 2 breast cancer PAP prostate acic phosphatase prostate cancer PART-1 prostate cancer PATE prostate cancer PDEF prostate cancer Pim-I-Kinase PinI Propyl isomerase prostate cancer PDTE prostate cancer PRAME preferentially expressed antigen of melanoma, lung cancer, leukemia, head and neck cancer, melanoma renal cell carcinoma, sarcoma prostein prostate cancer proteinase-3 PSA prostate-specific antigen prostate cancer PSCA prostate cancer PSGR prostate cancer PSM PSMA prostate-specific membrane antigen prostate cancer RAGE-1 renal antigen bladder cancer, renal cancer, sarcoma, colon cancer RHAMM/CD168 receptor for hyaluronic acid mediated leukemia motility RU1 renal ubiquitous 1 bladder cancer, melanoma, renal cancer RU2 renal ubiquitous 1 bladder cancer, melanoma, sarcoma, brain tumor, esophagel cancer, renal cancer, colon cancer, breast cancer S-100 melanoma SAGE sarcoma antigen SART-1 squamous antigen rejecting tumor 1 esophageal cancer, head and neck cancer, lung cancer, uterine cancer SART-2 squamous antigen rejecting tumor 1 head and neck cancer, lung cancer, renal cell carcinoma, melanoma, brain tumor SART-3 squamous antigen rejecting tumor 1 head and neck cancer, lung cancer, leukemia, melanoma, esophageal cancer SCC squamous cell carcinoma antigen lung cancer Sp17 sperm protein 17 multiple myeloma SSX-1 synovial sarcoma X breakpoint 1 hepatocellular cell carcinom, breast cancer SSX-2/HOM-MEL-40 synovial sarcoma X breakpoint 2 breast cancer SSX-4 synovial sarcoma X breakpoint 4 bladder cancer, hepatocellular cell carcinoma, breast cancer STAMP-1 prostate cancer STEAP six transmembrane epithelial antigen prostate cancer prostate survivin bladder cancer survivin-2B intron 2-retaining survivin bladder cancer TA-90 melanoma TAG-72 prostate carcinoma TARP prostate cancer TGFb TGFbeta TGFbRII TGFbeta receptor II TGM-4 prostate-specific transglutaminase prostate cancer TRAG-3 taxol resistant associated protein 3 breast cancer, leukemia, and melanoma TRG testin-related gene TRP-1 tyrosine related protein 1 melanoma TRP-2/6b TRP-2/novel exon 6b melanoma, glioblastoma TRP-2/INT2 TRP-2/intron 2 melanoma, glioblastoma Trp-p8 prostate cancer Tyrosinase melanoma UPA urokinase-type plasminogen activator breast cancer VEGF vascular endothelial growth factor VEGFR-2/FLK-1 vascular endothelial growth factor receptor-2 WTI Wilm' tumor gene gastric cancer, colon cancer, lung cancer, breast cancer, ovarian cancer, leukemia

TABLE 2 Mutant antigens expressed in cancer diseases Mutant antigen Name of mutant antigen Cancers or cancer diseases related thereto alpha-actinin-4/m lung carcinoma ARTC1/m melanoma bcr/abl breakpoint cluster region-Abelson fusion protein CML beta-Catenin/m beta-Catenin melanoma BRCA1/m breast cancer BRCA2/m breast cancer CASP-5/m colorectal cancer, gastric cancer, endometrial carcinoma CASP-8/m head and neck cancer, squamous cell carcinoma CDC27/m cell-division-cycle 27 CDK4/m cyclin-dependent kinase 4 melanoma CDKN2A/m melanoma CML66 CML CDA-1/m colorectal cancer DEK-CAN fusion protein AML EFTUD2/m melanoma ELF2/m Elongation factor 2 lung squamous cell carcinoma ETV6-AML1 Ets variant gene6/acute myeloid leukemia 1 gene fusion ALL protein FN1/m fibronectin 1 melanoma GPNMB/m melanoma HLA-A*0201-R170I arginine to isoleucine exchange at residue 170 of the renal cell carcinoma alpha-helix of the alpha2-domain in the HLA-A2 gene HLA-A11/m melanoma HLA-A2/m renal cell carcinoma HSP70-2M heat shock protein 70-2 mutated renal cell carcinoma, melanoma, neuroblastoma KIAA0205/m bladder tumor K-Ras/m pancreatic carcinoma, colorectal carcinoma LDLR-FUT LDR-Fucosyltransferase fusion protein melanoma MART2/m melanoma ME1/m non-small cell lung carcinoma MUM-1/m melanoma ubiquitous mutated 1 melanoma MUM-2/m melanoma ubiquitous mutated 2 melanoma MUM-3/m melanoma ubiquitous mutated 3 melanoma Myosin class I/m melanoma neo-PAP/m melanoma NFYC/m lung squamous cell carcinoma N-Ras/m melanoma OGT/m colorectal carcinoma OS-9/m melanoma p53/m Pml/RARa promyelocytic leukemia/retinoic acid receptor alpha APL, PML PRDX5/m melanoma PTPRK/m receptor-type protein-tyrosine phosphatase kappa melanoma RBAF600/m melanoma SIRT2/m melanoma SYT-SSX-1 synaptotagmin I/synovial sarcoma X fusion protein sarcoma SYT-SSX-2 synaptotagmin I/synovial sarcoma X fusion protein sarcoma TEL-AMLI translocation Ets-family leukemia/acute myeloid AML leukemia I fusion protein TGFbRII TGFbeta receptor II colorectal carcinoma TPI/m triosephosphate isomerase melanoma

In a preferred embodiment according to the invention, antibodies encoded by the inventive RNA are directed against the following (protein) antigens (whereby the RNA molecules may be used for the preparation of a medicament, e.g. a pharmaceutical composition or more preferably a (passive) vaccine in the meaning of the present inventino), are selected from the group consisting of 5T4, 707-AP, 9D7, AFP, AlbZIP HPG1, alpha-5-beta-1-integrin, alpha-5-beta-6-integrin, alpha-actinin-4/m, alpha-methylacyl-coenzyme A racemase, ART-4, ARTC1/m, B7H4, BAGE-1, BCL-2, bcr/abl, beta-catenin/m, BING-4, BRCA1/m, BRCA2/m, CA 15-3/CA 27-29, CA 19-9, CA72-4, CA125, calreticulin, CAMEL, CASP-8/m, cathepsin B, cathepsin L, CD19, CD20, CD22, CD25, CDE30, CD33, CD4, CD52, CD55, CD56, CD80, CDC27/m, CDK4/m, CDKN2A/m, CEA, CLCA2, CML28, CML66, COA-1/m, coactosin-like protein, collage XXIII, COX-2, CT-9/BRD6, Cten, cyclin B1, cyclin D1, cyp-B, CYPB1, DAM-10, DAM-6, DEK-CAN, EFTUD2/m, EGFR, ELF2/m, EMMPRIN, EpCam, EphA2, EphA3, ErbB3, ETV6-AML1, EZH2, FGF-5, FN, Frau-1, G250, GAGE-1, GAGE-2, GAGE-3, GAGE-4, GAGE-5, GAGE-6, GAGE7b, GAGE-8, GDEP, GnT-V, gp100, GPC3, GPNMB/m, HAGE, HAST-2, hepsin, Her2/neu, HERV-K-MEL, HLA-A*0201-R17I, HLA-A11/m, HLA-A2/m, HNE, homeobox NKX3.1, HOM-TES-14/SCP-1, HOM-TES-85, HPV-E6, HPV-E7, HSP70-2M, HST-2, hTERT, iCE, IGF-1R, IL-13Ra2, IL-2R, IL-5, immature laminin receptor, kallikrein-2, kallikrein-4, Ki67, KIAA0205, KIAA0205/m, KK-LC-1, K-Ras/m, LAGE-A1, LDLR-FUT, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A9, MAGE-A10, MAGE-A12, MAGE-B1, MAGE-B2, MAGE-B3, MAGE-B4, MAGE-B5, MAGE-B6, MAGE-B10, MAGE-B16, MAGE-B17, MAGE-C1, MAGE-C2, MAGE-C3, MAGE-D1, MAGE-D2, MAGE-D4, MAGE-E1, MAGE-E2, MAGE-F1, MAGE-H1, MAGEL2, mammaglobin A, MART-1/melan-A, MART-2, MART-2/m, matrix protein 22, MC1R, M-CSF, ME1/m, mesothelin, MG50/PXDN, MMP11, MN/CA IX-antigen, MRP-3, MUC-1, MUC-2, MUM-1/m, MUM-2/m, MUM-3/m, myosin class I/m, NA88-A, N-acetylglucosaminyltransferase-V, Neo-PAP, Neo-PAP/m, NFYC/m, NGEP, NMP22, NPM/ALK, N-Ras/m, NSE, NY-ESO-1, NY-ESO-B, OA1, OFA-iLRP, OGT, OGT/m, OS-9, OS-9/m, osteocalcin, osteopontin, p15, p190 minor bcr-abl, p53, p53/m, PAGE-4, PAI-1, PAI-2, PART-1, PATE, PDEF, Pim-1-Kinase, Pin-1, Pml/PARalpha, POTE, PRAME, PRDX5/m, prostein, proteinase-3, PSA, PSCA, PSGR, PSM, PSMA, PTPRK/m, RAGE-1, RBAF600/m, RHAMM/CD168, RU1, RU2, S-100, SAGE, SART-1, SART-2, SART-3, SCC, SIRT2/m, Sp17, SSX-1, SSX-2/HOM-MEL-40, SSX-4, STAMP-1, STEAP, survivin, survivin-2B, SYT-SSX-1, SYT-SSX-2, TA-90, TAG-72, TARP, TEL-AML1, TGFbeta, TGFbetaRII, TGM-4, TPI/m, TRAG-3, TRG, TRP-1, TRP-2/6b, TRP/INT2, TRP-p8, tyrosinase, UPA, VEGF, VEGFR-2/FLK-1, and WT1.

In a particularly preferred embodiment, the RNA codes for antibodies which are directed against protein antigens selected from the group consisting of MAGE-A1, MAGE-A6, melan-A, GP100, tyrosinase, survivin, CEA, Her-2/neu, WT1, PRAME, EGFRI (epidermal growth factor receptor 1), mucin-1 and SEC61G, hTERT, 5T4, NY-Eso1, and TRP-2, more preferably from sequences of group consisting of MAGE-A1 [accession number M77481], MAGE-A6 [accession number NM_005363], melan-A [accession number NM_005511], GP100 [accession number M77348], tyrosinase [accession number NM_000372], survivin [accession number AF077350], CEA [accession number NM_004363], Her-2/neu [accession number M11730], WT1 [accession number NM_000378], PRAME [accession number NM_006115], EGFRI (epidermal growth factor receptor 1) [accession number AF288738], mucin-1 [accession number NM_002456] and SEC61G [accession number NM_014302], hTERT [accession number NM_198253], 5T4 [accession number NM_006670], NY-Eso1 [accession number NM_001327], and TRP-2 [accession number NM_001922].

Antibodies (and therefore also the RNAs according to the invention on which these antibodies are based) which bind the antigens described here and, possibly, other antigens or nucleic acids can be identified e.g. by means of the method of phage display developed by George P. Smith. In this context, antibodies or antibody fragments are typically expressed on the surface of filamentous phages (Smith, G. P., 1985, “Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface”, Science 228; 1315-1317). For this there are conventionally 3 to 5 copies of the surface protein gplll on the proximal end of the phage, with the aid of which the phage infects bacteria cells via the F pilus thereof. In phage display, for example, the DNA for an antibody fragment which codes the antigen-binding variable domain is then cloned in-frame before the gplll gene. In protein biosynthesis, a fusion protein is formed therefrom, which is expressed on the virus surface without the phage losing its infectiousness. With the aid of the phage display technique, it is possible to generate large antibody libraries, each phage expressing a different antibody fragment on the surface. To this extent, the underlying RNA is therefore also available. A particular antibody fragment can be isolated from such a library by a method called “phage panning”. For this, the corresponding antigen is bound to a matrix and incubated with the phage suspension. The phages which present an appropriate antibody fragment interact with the fixed antigen, while the other phages are removed by a washing step. The phages isolated are multiplied, for example, in E. coli. The DNA is isolated accordingly and the gene sequence is determined. Expression constructs which contain the cDNA coding for the entire antibody or antibody fragments can then be developed with the aid of genetic engineering methods. An RNA (mRNA) which codes for the antibody can be generated from this cDNA by means of in vitro transcription (see below). Nucleic acids or, respectively, mRNA coding for monoclonal antibodies which are entirely of human origin are obtained in this manner.

In the context of the present invention, RNA according to the invention which codes for antibodies as described above is also suitable for coding so-called intrabodies or for rendering possible an expression of intrabodies. Intrabodies in the context of the present invention can include any of the antibodies or antibody fragments described here. Intrabodies are intracellularly expressed antibodies, i.e. antibodies which are coded by nucleic acids localized in the cell and are expressed there. For this, an RNA according to the invention which encodes the antibodies or antibody fragments as described above is introduced into cells beforehand, for example with the aid of transfection methods according to the invention or other suitable transfection methods and, where appropriate, thereafter transplanted into an organism or being or introduced directly as nucleic acids into an organism or being. In this context (irrespective of whether an an intrabody or a secreted antibody shall be introduce into the cell), the RNA according to the invention (or a corresponding nucleic acid) can be introduced in the naked form or as a complex with suitable carriers (e.g. liposomes) into the organism or the being or can have such modifications (of the RNA) which, where appropriate together with one of the transfection methods mentioned, lead to a better cell uptake, e.g. any of the RNA modifications mentioned here, such as, for example, lipid modifications of the RNA according to the invention. An organism or a being in connection with the present invention typically means mammals, i.e. animals, including cattle, pig, dog, cat, donkey, monkey, rodents, e.g. mouse, hamster, rabbit etc., and humans. Intrabodies can be localized and expressed at certain sites in the cell. For example, intrabodies can be expressed in the cytoplasm, the formation of disulfide bridges usually being decreased under the reducing conditions of the cytoplasm. It has been possible to demonstrate, however, that cytoplasmic intrabodies, and in particular scFv fragments, can be functional. Cytoplasmic expression by the RNA according to the invention opens up the possibility of also inhibiting cytoplasmic proteins. This is not possible with treatment with monoclonal antibodies from the prior art, since these antibodies can reach only secreted and membrane-located (extracellular) proteins due to their secretion from the cell after intracellular expression (which represents the major difference between antibodies and intrabodies). By expression of a signal peptide, intrabodies can be transported into the endoplasmic reticulum (ER) and then secreted as with regular antibodies. In this case, typically only secreted or membrane-located proteins are a target for these antibodies. By additional coding of a C-terminal ER retention signal (for example KDEL) by the RNA according to the invention, the intrabody can remain in the ER (where it may bind to specific antigen located in the ER) and prevent secretion of its antigen and/or transport of its antigen or its target molecule to the plasma membrane. Depending on the requirement, intrabodies can include full length antibodies or antibody fragments as described above. Intrabodies in the context of the present invention preferably initially include full length antibodies, which are retained in the cell and not secreted from the cell (by whatever technique, e.g. retention signal sequences etc.). However, if e.g. intracellular expression of full length antibodies is technically not possible or not appropriate, antibody fragments as described above can also be employed as intrabodies.

Preferably, the antibody encoded by the at least one coding sequence of the RNA is an antibody as defined herein, which is encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734.

In a preferred embodiment, the present invention thus provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of nucleic acid sequences according to SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

In certain embodiments, the RNA according to the invention, preferably the at least one coding sequence of the RNA according to the invention, may comprise or consist of a fragment of a nucleic acid sequence encoding an antibody or a fragment or variant thereof as defined herein. Preferably, the RNA according to the invention, preferably the at least one coding sequence of the RNA according to the invention, comprises or consists of a fragment of a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or of a variant of any one of said nucleic acid sequences.

In this context, a ‘fragment of a nucleic acid sequence’ is preferably a nucleic acid sequence encoding a fragment of an antibody or of a variant thereof as described herein. More preferably, the expression ‘fragment of a nucleic acid sequence’ refers to a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a respective full-length nucleic acid sequence.

In another preferred embodiment, the RNA according to the invention, preferably the at least one coding sequence of the RNA according to the invention, may comprise or consist of a variant of a nucleic acid sequence as defined herein, preferably of a nucleic acid sequence encoding an antibody or a fragment thereof as defined herein. The expression ‘variant of a nucleic acid sequence’ as used herein in the context of a nucleic acid sequence encoding an antibody or a fragment thereof, typically refers to a nucleic acid sequence, which differs by at least one nucleic acid residue from the respective reference nucleic acid sequence encoding an antibody or a fragment thereof. More preferably, the expression ‘variant of a nucleic acid sequence’ refers to a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence, from which it is derived.

Preferably, the RNA according to the invention, more preferably the at least one coding sequence of the RNA according to the invention, encodes a variant of an antibody or a fragment thereof, preferably as defined herein.

In a preferred embodiment, the RNA according to the invention, more preferably the at least one coding sequence of the RNA according to the invention, comprises or consists of a variant of a nucleic acid sequence encoding an antibody or a fragment thereof as defined herein, wherein the variant of the nucleic acid sequence encodes an amino acid sequence comprising at least one conservative substitution of an amino acid residue.

In another embodiment, the RNA according to the invention, more preferably the at least one coding sequence of the RNA according to the invention, comprises or consists of a variant of a nucleic acid sequence encoding an antibody or a fragment thereof as defined herein, wherein the nucleic acid sequence of the variant differs from the respective reference nucleic acid sequence in at least one nucleic acid residue, preferably without resulting—due to the degenerated genetic code—in an alteration of the encoded amino acid sequence, i.e. the amino acid sequence encoded by the variant or at least part thereof may preferably not differ from the reference amino acid sequence in one or more mutation(s) within the above meaning.

Furthermore, a ‘variant’ of a nucleic acid sequence encoding an antibody or a fragment or variant thereof as defined herein, may also comprise DNA sequences, which correspond to RNA sequences as defined herein and may also comprise further RNA sequences, which correspond to DNA sequences as defined herein. Those skilled in the art are familiar with the translation of an RNA sequence into a DNA sequence (or vice versa) or with the creation of the complementary strand sequence (i.e. by substitution of U residues with T residues and/or by constructing the complementary strand with respect to a given sequence).

According to a preferred embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence encoding a reference full-length antibody as defined herein, or a variant thereof.

In a further preferred embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

According to a particularly preferred embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 80% with a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment of any one of said nucleic acid sequences.

Table 3 below shows the assignment of amino acid sequences and RNA sequences of exemplified antibodies, which are preferably encoded by the RNA according to the present invention as described herein. In particular, the first column of Table 3 (“Name”) identifies (i) the antibody name and (ii) the antibody fragment (or complete antibody) encoded by the respective amino acid or RNA sequences, for example the chain (e.g., heavy chain, light chain, or any alternative/variant thereof) or the variable region. If the respective amino acid or RNA sequences encodes a fragment of a chain only (such as a certain region of an antibody chain), this can be retrieved from the column “Name”. In other words, unless otherwise indicated under “name”, the sequences provided relate to full length heavy or light chain sequences of the respective antibodies. However, it is also preferred that the coding sequence of the RNA according to the present invention encodes a fragment or a variant of the antibody sequences (e.g. heavy chain or light chain sequences) shown in Table 3 below.

TABLE 3 RNA and amino acid sequences of exemplified antibodies Name Protein SEQ ID NO RNA SEQ ID NO AAB-003_gamma1-Chain 1 7643, 15285, 22927, 30569, 38211, 45853, 53495 Abagovomab_HeavyChain 2 7644, 15286, 22928, 30570, 38212, 45854, 53496 Abagovomab_LightChain 3 7645, 15287, 22929, 30571, 38213, 45855, 53497 Abciximab_HeavyChain 4 7646, 15288, 22930, 30572, 38214, 45856, 53498 Abciximab_LightChain 5 7647, 15289, 22931, 30573, 38215, 45857, 53499 Abituzumab_HeavyChain1 6 7648, 15290, 22932, 30574, 38216, 45858, 53500 Abituzumab_LightChain1 7 7649, 15291, 22933, 30575, 38217, 45859, 53501 Abrilumab_HeavyChain1 8 7650, 15292, 22934, 30576, 38218, 45860, 53502 Abrilumab_LightChain1 9 7651, 15293, 22935, 30577, 38219, 45861, 53503 Abrilumab_LightChain1_variant2 10 7652, 15294, 22936, 30578, 38220, 45862, 53504 Actoxumab_HeavyChain1 11 7653, 15295, 22937, 30579, 38221, 45863, 53505 Actoxumab_LightChain1 12 7654, 15296, 22938, 30580, 38222, 45864, 53506 Adalimumab_HeavyChain 13 7655, 15297, 22939, 30581, 38223, 45865, 53507 Adalimumab_LightChain 14 7656, 15298, 22940, 30582, 38224, 45866, 53508 Aducanumab_HeavyChain1 15 7657, 15299, 22941, 30583, 38225, 45867, 53509 Aducanumab_LightChain1 16 7658, 15300, 22942, 30584, 38226, 45868, 53510 Afasevikumab_HeavyChain1 17 7659, 15301, 22943, 30585, 38227, 45869, 53511 Afasevikumab_LightChain1 18 7660, 15302, 22944, 30586, 38228, 45870, 53512 Aflibercept_Fusion_protein1 19 7661, 15303, 22945, 30587, 38229, 45871, 53513 Afutuzuab_HeavyChain1 20 7662, 15304, 22946, 30588, 38230, 45872, 53514 Afutuzuab_LightChain1 21 7663, 15305, 22947, 30589, 38231, 45873, 53515 Afutuzumab_HeavyChain1 22 7664, 15306, 22948, 30590, 38232, 45874, 53516 Afutuzumab_LightChain1 23 7665, 15307, 22949, 30591, 38233, 45875, 53517 Alacizumab_pegol_HeavyChain1 24 7666, 15308, 22950, 30592, 38234, 45876, 53518 Alacizumab_pegol_LightChain1 25 7667, 15309, 22951, 30593, 38235, 45877, 53519 Alemtuzumab_HeavyChain 26 7668, 15310, 22952, 30594, 38236, 45878, 53520 Alemtuzumab_HeavyChain_variant_Ibey_H 27 7669, 15311, 22953, 30595, 38237, 45879, 53521 Alemtuzumab_HeavyChain_variant_Icel_H 28 7670, 15312, 22954, 30596, 38238, 45880, 53522 Alemtuzumab_HeavyChain_variant_8005_H 29 7671, 15313, 22955, 30597, 38239, 45881, 53523 Alemtuzumab_LightChain 30 7672, 15314, 22956, 30598, 38240, 45882, 53524 Alemtuzumab_LightChain_variant_8005_L 31 7673, 15315, 22957, 30599, 38241, 45883, 53525 Alirocumab_HeavyChain1 32 7674, 15316, 22958, 30600, 38242, 45884, 53526 Alirocumab_LightChain1 33 7675, 15317, 22959, 30601, 38243, 45885, 53527 ALX-0061_HeavyChain1 34 7676, 15318, 22960, 30602, 38244, 45886, 53528 Amatuximab_HeavyChain1 35 7677, 15319, 22961, 30603, 38245, 45887, 53529 Amatuximab_LightChain1 36 7678, 15320, 22962, 30604, 38246, 45888, 53530 Anetumab_ravtansine_HeavyChain1 37 7679, 15321, 22963, 30605, 38247, 45889, 53531 Anetumab_ravtansine_LightChain1 38 7680, 15322, 22964, 30606, 38248, 45890, 53532 Anifrolumab_HeavyChain1 39 7681, 15323, 22965, 30607, 38249, 45891, 53533 Anifrolumab_LightChain1 40 7682, 15324, 22966, 30608, 38250, 45892, 53534 Anrukinzumab_HeavyChain1 41 7683, 15325, 22967, 30609, 38251, 45893, 53535 Anrukinzumab_LightChain1 42 7684, 15326, 22968, 30610, 38252, 45894, 53536 Apolizumab_HeavyChain1 43 7685, 15327, 22969, 30611, 38253, 45895, 53537 Apolizumab_LightChain1 44 7686, 15328, 22970, 30612, 38254, 45896, 53538 Apomab_HeavyChain 45 7687, 15329, 22971, 30613, 38255, 45897, 53539 Apomab_LightChain 46 7688, 15330, 22972, 30614, 38256, 45898, 53540 Aquaporumab_LightChain 47 7689, 15331, 22973, 30615, 38257, 45899, 53541 Arcitumomab_99tc_HeavyChain 48 7690, 15332, 22974, 30616, 38258, 45900, 53542 Arcitumomab_99tc_LightChain 49 7691, 15333, 22975, 30617, 38259, 45901, 53543 Ascrinvacumab_HeavyChain1 50 7692, 15334, 22976, 30618, 38260, 45902, 53544 Ascrinvacumab_LightChain1 51 7693, 15335, 22977, 30619, 38261, 45903, 53545 Aselizuab_HeavyChain1 52 7694, 15336, 22978, 30620, 38262, 45904, 53546 Aselizuab_HeavyChain2 53 7695, 15337, 22979, 30621, 38263, 45905, 53547 Aselizuab_LightChain1 54 7696, 15338, 22980, 30622, 38264, 45906, 53548 Atezolizumab_HeavyChain1 55 7697, 15339, 22981, 30623, 38265, 45907, 53549 Atezolizumab_LightChain1 56 7698, 15340, 22982, 30624, 38266, 45908, 53550 Atinumab_HeavyChain1 57 7699, 15341, 22983, 30625, 38267, 45909, 53551 Atinumab_LightChain1 58 7700, 15342, 22984, 30626, 38268, 45910, 53552 Atlizuab_HeavyChain1 59 7701, 15343, 22985, 30627, 38269, 45911, 53553 Atlizuab_LightChain1 60 7702, 15344, 22986, 30628, 38270, 45912, 53554 Aurograb_SingleChain 61 7703, 15345, 22987, 30629, 38271, 45913, 53555 Avelumab_HeavyChain1 62 7704, 15346, 22988, 30630, 38272, 45914, 53556 Avelumab_LightChain1 63 7705, 15347, 22989, 30631, 38273, 45915, 53557 Bapineuzumab_HeavyChain1 64 7706, 15349, 22990, 30632, 38274, 45916, 53558 Bapineuzumab_LightChain1 65 7707, 15349, 22991, 30633, 38275, 45917, 53559 Basiliximab_HeavyChain 66 7708, 15350, 22992, 30634, 38276, 45918, 53560 Basiliximab_LightChain 67 7709, 15351, 22993, 30635, 38277, 45919, 53561 Bavituximab_HeavyChain 68 7710, 15352, 22994, 30636, 38278, 45920, 53562 Bavituximab_LightChain 69 7711, 15353, 22995, 30637, 38279, 45921, 53563 Bavituximab_LightChain_variant_8734_L 70 7712, 15354, 22996, 30638, 38280, 45922, 53564 Begelomab_HeavyChain1 71 7713, 15355, 22997, 30639, 38281, 45923, 53565 Begelomab_LightChain1 72 7714, 15356, 22998, 30640, 38282, 45924, 53566 Benralizumab_HeavyChain1 73 7715, 15357, 22999, 30641, 38283, 45925, 53567 Benralizumab_LightChain1 74 7716, 15358, 23000, 30642, 38284, 45926, 53568 Betalutin_HeavyChain1 75 7717, 15359, 23001, 30643, 38285, 45927, 53569 Betalutin_LightChain1 76 7718, 15360, 23002, 30644, 38286, 45928, 53570 Bevacituzuab_HeavyChain1 77 7719, 15361, 23003, 30645, 38287, 45929, 53571 Bevacituzuab_LightChain1 78 7720, 15362, 23004, 30646, 38288, 45930, 53572 Bevacizumab_154-aspartic_acid_LightChain 79 7721, 15363, 23005, 30647, 38289, 45931, 53573 Bevacizumab_154-substitution_deriv_LightChain 80 7722, 15364, 23006, 30648, 38290, 45932, 53574 Bevacizumab_180-serine_HeavyChain 81 7723, 15365, 23007, 30649, 38291, 45933, 53575 Bevacizumab_180-substitution_deriv_HeavyCahin 82 7724, 15366, 23008, 30650, 38292, 45934, 53576 Bevacizumab_beta_HeavyChain1 83 7725, 15367, 23009, 30651, 38293, 45935, 53577 Bevacizumab_beta_LightChain1 84 7726, 15368, 23010, 30652, 38294, 45936, 53578 Bevacizumab_FcDomain 85 7727, 15369, 23011, 30653, 38295, 45937, 53579 Bevacizumab_HeavyChain 86 7728, 15370, 23012, 30654, 38296, 45938, 53580 Bevacizumab_HeavyChain_variant1 87 7729, 15371, 23013, 30655, 38297, 45939, 53581 Bevacizumab_HeavyChain_V-Region 88 7730, 15372, 23014, 30656, 38298, 45940, 53582 Bevacizumab_LightChain1 89 7731, 15373, 23015, 30657, 38299, 45941, 53583 Bevacizumab_LightChain2 90 7732, 15374, 23016, 30658, 38300, 45942, 53584 Bevacizumab_LightChain 91 7733, 15375, 23017, 30659, 38301, 45943, 53585 Bevacizumab_LightChain_VJ-Region 92 7734, 15376, 23018, 30660, 38302, 45944, 53586 Bevacizumab_LightChain_V-Region 93 7735, 15377, 23019, 30661, 38303, 45945, 53587 Bevacizumah-rhuMAb-VEGF_HeavyChain_gamma1- 94 7736, 15378, 23020, 30662, 38304, 45946, 53588 Chain_VDJ-Region Bevacizumah-rhuMAb-VEGF_LightChain_VJ-Region 95 7737, 15379, 23021, 30663, 38305, 45947, 53589 Bevacizumab_gamma1-Chain 96 7738, 15380, 23022, 30664, 38306, 45948, 53590 Bevacizumab_gamma1-Chain_CH3-Region_mutein 97 7739, 15381, 23023, 30665, 38307, 45949, 53591 Bezlotoxumab_HeavyChain1 98 7740, 15382, 23024, 30666, 38308, 45950, 53592 Bezlotoxumab_LightChain1 99 7741, 15383, 23025, 30667, 38309, 45951, 53593 Bimagrumab_HeavyChain1 100 7742, 15384, 23026, 30668, 38310, 45952, 53594 Bimagrumab_HeavyChain 101 7743, 15385, 23027, 30669, 38311, 45953, 53595 Bimagrumab_LightChain1 102 7744, 15386, 23028, 30670, 38312, 45954, 53596 Bimekizumab_HeavyChain1 103 7745, 15387, 23029, 30671, 38313, 45955, 53597 Bimekizumab_LightChain1 104 7746, 15388, 23030, 30672, 38314, 45956, 53598 Bleselumab_HeavyChain1 105 7747, 15389, 23031, 30673, 38315, 45957, 53599 Bleselumab_LightChain1 106 7748, 15390, 23032, 30674, 38316, 45958, 53600 Blinatumomab_HeavyChain1 107 7749, 15391, 23033, 30675, 38317, 45959, 53601 Blinatumomab_SingleChain 108 7750, 15392, 23034, 30676, 38318, 45960, 53602 Blinatumumab_SingleChain_variable_fragment_fusion_protein_(bite) 109 7751, 15393, 23035, 30677, 38319, 45961, 53603 Blontuvetmab_HeavyChain 110 7752, 15394, 23036, 30678, 38320, 45962, 53604 Blontuvetmab_LightChain 111 7753, 15395, 23037, 30679, 38321, 45963, 53605 Blosozumab_HeavyChain1 112 7754, 15396, 23038, 30680, 38322, 45964, 53606 Blosozumab_LightChain1 113 7755, 15397, 23039, 30681, 38323, 45965, 53607 Bococizumab_HeavyChain1 114 7756, 15398, 23040, 30682, 38324, 45966, 53608 Bococizumab_LightChain1 115 7757, 15399, 23041, 30683, 38325, 45967, 53609 Brentuximab_vedotin_HeavyChain1 116 7758, 15400, 23042, 30684, 38326, 45968, 53610 Brentuximab_vedotin_LightChain1 117 7759, 15401, 23043, 30685, 38327, 45969, 53611 Briakinumab_HeavyChain1 118 7760, 15402, 23044, 30686, 38328, 45970, 53612 Briakinumab_LightChain1 119 7761, 15403, 23045, 30687, 38329, 45971, 53613 Brodalumab_HeavyChain1 120 7762, 15404, 23046, 30688, 38330, 45972, 53614 Brodalumab_LightChain1 121 7763, 15405, 23047, 30689, 38331, 45973, 53615 Brolucizumab_HeavyChain1 122 7764, 15406, 23048, 30690, 38332, 45974, 53616 Brolucizuma_scFv_fragment 123 7765, 15407, 23049, 30691, 38333, 45975, 53617 Brontictuzumab_HeavyChain1 124 7766, 15408, 23050, 30692, 38334, 45976, 53618 Brontictuzumab_LightChain1 125 7767, 15409, 23051, 30693, 38335, 45977, 53619 BTT-1023_HeavyChain1 126 7768, 15410, 23052, 30694, 38336, 45978, 53620 BTT-1023_LightChain1 127 7769, 15411, 23053, 30695, 38337, 45979, 53621 Burosumab_HeavyChain1 128 7770, 15412, 23054, 30696, 38338, 45980, 53622 Burosumab_LightChain1 129 7771, 15413, 23055, 30697, 38339, 45981, 53623 Canakinumab_HeavyChain1 130 7772, 15414, 23056, 30698, 38340, 45982, 53624 Canakinumab_HeavyChain 131 7773, 15415, 23057, 30699, 38341, 45983, 53625 Canakinumab_LightChain1 132 7774, 15416, 23058, 30700, 38342, 45984, 53626 Canakinumab_LightChain 133 7775, 15417, 23059, 30701, 38343, 45985, 53627 Canakinumab_LightChain_variant_8836_L 134 7776, 15418, 23060, 30702, 38344, 45986, 53628 Cantuzumab_HeavyChain1 135 7777, 15419, 23061, 30703, 38345, 45987, 53629 Cantuzumab_HeavyChain 136 7778, 15420, 23062, 30704, 38346, 45988, 53630 Cantuzumab_LightChain1 137 7779, 15421, 23063, 30705, 38347, 45989, 53631 Cantuzumab_mertansine_HeavyChain1 138 7780, 15422, 23064, 30706, 38348, 45990, 53632 Cantuzumab_mertansine_LightChain1 139 7781, 15423, 23065, 30707, 38349, 45991, 53633 Cantuzumab_ravtansine_HeavyChain1 140 7782, 15424, 23066, 30708, 38350, 45992, 53634 Cantuzumab_ravtansine_LightChain1 141 7783, 15425, 23067, 30709, 38351, 45993, 53635 Caplacizumab 142 7784, 15426, 23068, 30710, 38352, 45994, 53636 Caplacizumab_HeavyChain1 143 7785, 15427, 23069, 30711, 38353, 45995, 53637 Caplacizumab_HeavyChain1 144 7786, 15428, 23070, 30712, 38354, 45996, 53638 Carlumab_HeavyChain1 145 7787, 15429, 23071, 30713, 38355, 45997, 53639 Carlumab_LightChain1 146 7788, 15430, 23072, 30714, 38356, 45998, 53640 Cergutuzumab_amunaleukin_HeavyChain1 147 7789, 15431, 23073, 30715, 38357, 45999, 53641 Cergutuzumab_amunaleukin_HeavyChain2 148 7790, 15432, 23074, 30716, 38358, 46000, 53642 Cergutuzumab_amunaleukin_LightChain1 149 7791, 15433, 23075, 30717, 38359, 46001, 53643 Certolizumab_pegol_HeavyChain1 150 7792, 15434, 23076, 30718, 38360, 46002, 53644 Certolizumab_pegol_HeavyChain 151 7793, 15435, 23077, 30719, 38361, 46003, 53645 Certolizumab_pegol_LightChain1 152 7794, 15436, 23078, 30720, 38362, 46004, 53646 Certolizumab_pegol_LightChain 153 7795, 15437, 23079, 30721, 38363, 46005, 53647 Cetuximab_HeavyChain 154 7796, 15438, 23080, 30722, 38364, 46006, 53648 Cetuximab_HeavyChain_variant 155 7797, 15439, 23081, 30723, 38365, 46007, 53649 Cetuximab_LightChain 156 7798, 15440, 23082, 30724, 38366, 46008, 53650 Cetuximab_LightChain_variant 157 7799, 15441, 23083, 30725, 38367, 46009, 53651 Citatuzumab_bogatox_HeavyChain1 158 7780, 15442, 23084, 30726, 38368, 46010, 53652 Citatuzumab_bogatox_LightChain1 159 7801, 15443, 23085, 30727, 38369, 46011, 53653 Cixutumumab_HeavyChain1 160 7802, 15444, 23086, 30728, 38370, 46012, 53654 Cixutumumab_LightChain1 161 7803, 15445, 23087, 30729, 38371, 46013, 53655 Clazakizumab_HeavyChain1 162 7804, 15446, 23088, 30730, 38372, 46014, 53656 Clazakizumab_LightChain1 163 7805, 15447, 23089, 30731, 38373, 46015, 53657 Clivatuzumab_tetraxetan_HeavyChain1 164 7806, 15448, 23090, 30732, 38374, 46016, 53658 Clivatuzumab_tetraxetan_LightChain1 165 7807, 15449, 23091, 30733, 38375, 46017, 53659 Codrituzumab_HeavyChain1 166 7808, 15450, 23092, 30734, 38376, 46018, 53660 Codrituzumab_LightChain1 167 7809, 15451, 23093, 30735, 38377, 46019, 53661 Coltuximab_ravtansine_HeavyChain1 168 7810, 15452, 23094, 30736, 38378, 46020, 53662 Coltuximah_ravtansine_LightChain1 169 7811, 15453, 23095, 30737, 38379, 46021, 53663 Conatumumab_CV_HeavyChain 170 7812, 15454, 23096, 30738, 38380, 46022, 53664 Conatumumab_CV_LightChain 171 7813, 15455, 23097, 30739, 38381, 46023, 53665 Conatumumab_HeavyChain1 172 7814, 15456, 23098, 30740, 38382, 46024, 53666 Conatumumab_HeavyChain 173 7815, 15457, 23099, 30741, 38383, 46025, 53667 Conatumumab_LightChain1 174 7816, 15458, 23100, 30742, 38384, 46026, 53668 Conatumumab_LightChain 175 7817, 15459, 23101, 30743, 38385, 46027, 53669 Concizumab_HeavyChain1 175 7818, 15460, 23102, 30744, 38386, 46028, 53670 Concizumab_LightChain1 177 7819, 15461, 23103, 30745, 38387, 46029, 53671 Crenezumab_HeavyChain1 178 7820, 15462, 23104, 30746, 38388, 46030, 53672 Crenezumab_LightChain1 179 7821, 15463, 23105, 30747, 38389, 46031, 53673 Crotedumab_HeavyChain1 180 7822, 15464, 23106, 30748, 38390, 46032, 53674 Crotedumab_HeavyChain2 181 7823, 15465, 23107, 30749, 38391, 46033, 53675 Crotedumab_LightChain1 182 7824, 15466, 23108, 30750, 38392, 46034, 53676 Crotedumab_LightChain2 183 7825, 15467, 23109, 30751, 38393, 46035, 53677 Dacetuzumab_HeavyChain1 184 7826, 15468, 23110, 30752, 38394, 46036, 53678 Dacetuzumab_LightChain1 185 7827, 15469, 23111, 30753, 38395, 46037, 53679 Dacliximab_LightChain_VJ-Region 186 7828, 15470, 23112, 30754, 38396, 46038, 53680 Dacliximab_gamma2-Chain_VDJ-Region 187 7829, 15471, 23113, 30755, 38397, 46039, 53681 Daclizumab_HeavyChain 188 7830, 15472, 23114, 30756, 38398, 46040, 53682 Daclizumab_LightChain 189 7831, 15473, 23115, 30757, 38399, 46041, 53683 Dalotuzumab_HeavyChain1 190 7832, 15474, 23116, 30758, 38400, 46042, 53684 Dalotuzumab_LightChain1 191 7833, 15475, 23117, 30759, 38401, 46043, 53685 Dapirolizumab_pegol_HeavyChain1 192 7834, 15476, 23118, 30760, 38402, 46044, 53686 Dapirolizumab_pegol_LightChain1 193 7835, 15477, 23119, 30761, 38403, 46045, 53687 Daratumumab_HeavyChain1 194 7836, 15478, 23120, 30762, 38404, 46046, 53688 Daratumumab_LightChain1 195 7837, 15479, 23121, 30763, 38405, 46047, 53689 Dectrekumab_HeavyChain1 196 7838, 15480, 23122, 30764, 38406, 46048, 53690 Dectrekumab_LightChain1 197 7839, 15481, 23123, 30765, 38407, 46049, 53691 Demcizumab_HeavyChain1 198 7840, 15482, 23124, 30766, 38408, 46050, 53692 Demcizumab_LightChain1 199 7841, 15483, 23125, 30767, 38409, 46051, 53693 Denintuzumab_mafodotin_HeavyChain1 200 7842, 15484, 23126, 30768, 38410, 46052, 53694 Denintuzumab_mafodotin_LightChain1 201 7843, 15485, 23127, 30769, 38411, 46053, 53695 Denosumab_HeavyChain 202 7844, 15486, 23128, 30770, 38412, 46054, 53696 Denosumab_LightChain 203 7845, 15487, 23129, 30771, 38413, 46055, 53697 Depatuxizumab_HeavyChain1 204 7846, 15488, 23130, 30772, 38414, 46056, 53698 Depatuxizumab_LightChain1 205 7847, 15489, 23131, 30773, 38415, 46057, 53699 Depatuxizumab_mafodotin_HeavyChain1 206 7848, 15490, 23132, 30774, 38416, 46058, 53700 Depatuxizumab_mafodotin_LightChain1 207 7849, 15491, 23133, 30775, 38417, 46059, 53701 Dinutuximab_beta_HeavyChain1 208 7850, 15492, 23134, 30776, 38418, 46060, 53702 Dinutuximab_beta_LightChain1 209 7851, 15493, 23135, 30777, 38419, 46061, 53703 Dinutuximab_HeavyChain1 210 7852, 15494, 23136, 30778, 38420, 46062, 53704 Dinutuximab_LightChain1 211 7853, 15495, 23137, 30779, 38421, 46063, 53705 Dinutuximab_LightChain 212 7854, 15496, 23138, 30780, 38422, 46064, 53706 Diridavumab_HeavyChain1 213 7855, 15497, 23139, 30781, 38423, 46065, 53707 Diridavumab_LightChain1 214 7856, 15498, 23140, 30782, 38424, 46066, 53708 Domagrozumab_HeavyChain1 215 7857, 15499, 23141, 30783, 38425, 46067, 53709 Domagrozumab_HeavyChain 216 7858, 15500, 23142, 30784, 38426, 46068, 53710 Domagrozumab_LightChain1 217 7859, 15501, 23143, 30785, 38427, 46069, 53711 Drozituab_HeavyChain1 218 7860, 15502, 23144, 30786, 38428, 46070, 53712 Drozituab_LightChain1 219 7861, 15503, 23145, 30787, 38429, 46071, 53713 Drozitumab_HeavyChain1 220 7862, 15504, 23146, 30788, 38430, 46072, 53714 Drozitumab_LightChain1 221 7863, 15505, 23147, 30789, 38431, 46073, 53715 Duligotumab_HeavyChain1 222 7864, 15506, 23148, 30790, 38432, 46074, 53716 Duligotumab_LightChain1 223 7865, 15507, 23149, 30791, 38433, 46075, 53717 Duligotuzumab_HeavyChain1 224 7866, 15508, 23150, 30792, 38434, 46076, 53718 Duligotuzumab_LightChain1 225 7867, 15509, 23151, 30793, 38435, 46077, 53719 Dupilumab_HeavyChain1 226 7868, 15510, 23152, 30794, 38436, 46078, 53720 Dupilumab_LightChain1 227 7869, 15511, 23153, 30795, 38437, 46079, 53721 Durvalumab_HeavyChain1 228 7870, 15512, 23154, 30796, 38438, 46080, 53722 Durvalumab_LightChain1 229 7871, 15513, 23155, 30797, 38439, 46081, 53723 Dusigitumab_HeavyChain1 230 7872, 15514, 23156, 30798, 38440, 46082, 53724 Dusigitumab_LightChain1 231 7873, 15515, 23157, 30799, 38441, 46083, 53725 Ecromeximab_HeavyChain1 232 7874, 15516, 23158, 30800, 38442, 46084, 53726 Ecromeximab_LightChain1 233 7875, 15517, 23159, 30801, 38443, 46085, 53727 Eculizumab_HeavyChain1 234 7876, 15518, 23160, 30802, 38444, 46086, 53728 Eculizumab_LightChain1 235 7877, 15519, 23161, 30803, 38445, 46087, 53729 Efalizumab_HeavyChain 236 7878, 15520, 23162, 30804, 38446, 46088, 53730 Efalizumab_LightChain 237 7879, 15521, 23163, 30805, 38447, 46089, 53731 Efungumab_SingleChain_variable_fragment 238 7880, 15522, 23164, 30806, 38448, 46090, 53732 Eldelumab_HeavyChain1 239 7881, 15523, 23165, 30807, 38449, 46091, 53733 Eldelumab_LightChain1 240 7882, 15524, 23166, 30808, 38450, 46092, 53734 Elgemtumab_HeavyChain1 241 7883, 15525, 23167, 30809, 38451, 46093, 53735 Elgemtumab_LightChain1 242 7884, 15526, 23168, 30810, 38452, 46094, 53736 Elotuzumab_HeavyChain1 243 7885, 15527, 23169, 30811, 38453, 46095, 53737 Elotuzumab_LightChain1 244 7886, 15528, 23170, 30812, 38454, 46096, 53738 Emactuzumab_HeavyChain1 245 7887, 15529, 23171, 30813, 38455, 46097, 53739 Emactuzumab_LightChain1 246 7888, 15530, 23172, 30814, 38456, 46098, 53740 Emibetuzumab_HeavyChain1 247 7889, 15531, 23173, 30815, 38457, 46099, 53741 Emibetuzumab_LightChain1 248 7890, 15532, 23174, 30816, 38458, 46100, 53742 Emicizumab_HeavyChain1 249 7891, 15533, 23175, 30817, 38459, 46101, 53743 Emicizumab_HeavyChain2 250 7892, 15534, 23176, 30818, 38460, 46102, 53744 Emicizumab_LightChain1 251 7893, 15535, 23177, 30819, 38461, 46103, 53745 Enavatuzumab_HeavyChain1 252 7894, 15536, 23178, 30820, 38462, 46104, 53746 Enavatuzumab_LightChain1 253 7895, 15537, 23179, 30821, 38463, 46105, 53747 Enfortumab_HeavyChain 254 7896, 15538, 23180, 30822, 38464, 46106, 53748 Enfortumab_LightChain 255 7897, 15539, 23181, 30823, 38465, 46107, 53749 Enfortumab_vedotin_HeavyChain1 256 7898, 15540, 23182, 30824, 38466, 46108, 53750 Enfortumab_vedotin_LightChain1 257 7899, 15541, 23183, 30825, 38467, 46109, 53751 Enoblituzumab_HeavyChain 258 7900, 15542, 23184, 30826, 38468, 46110, 53752 Enoblituzumab_LightChain 259 7901, 15543, 23185, 30827, 38469, 46111, 53753 Enokizumab_HeavyChain1 260 7902, 15544, 23186, 30828, 38470, 46112, 53754 Enokizumab_LightChain1 261 7903, 15545, 23187, 30829, 38471, 46113, 53755 Enokizumab_LightChain 262 7904, 15546, 23188, 30830, 38472, 46114, 53756 Enoticumab_HeavyChain1 263 7905, 15547, 23189, 30831, 38473, 46115, 53757 Enoticumab_LightChain1 264 7906, 15548, 23190, 30832, 38474, 46116, 53758 Ensituximab_HeavyChain1 265 7907, 15549, 23191, 30833, 38475, 46117, 53759 Ensituximab_LightChain1 266 7908, 15550, 23192, 30834, 38476, 46118, 53760 Ensituximab_SingleChain_variable_fragment 267 7909, 15551, 23193, 30835, 38477, 46119, 53761 Entolimod_Chain1 268 7910, 15552, 23194, 30836, 38478, 46120, 53762 Epratuzumab_HeavyChain 269 7911, 15553, 23195, 30837, 38479, 46121, 53763 Epratuzumab_LightChain 270 7912, 15554, 23196, 30838, 38480, 46122, 53764 Eptacog_beta_HeavyChain1 271 7913, 15555, 23197, 30839, 38481, 46123, 53765 Eptacog_beta_LightChain1 272 7914, 15556, 23198, 30840, 38482, 46124, 53766 Erlizuab_HeavyChain1 273 7915, 15557, 23199, 30841, 38483, 46125, 53767 Erlizuab_LightChain1 274 7916, 15558, 23200, 30842, 38484, 46126, 53768 Etaracizumab_HeavyChain1 275 7917, 15559, 23201, 30843, 38485, 46127, 53769 Etaracizumab_LightChain1 276 7918, 15560, 23202, 30844, 38486, 46128, 53770 Etrolizumab_HeavyChain1 277 7919, 15561, 23203, 30845, 38487, 46129, 53771 Etrolizumab_HeavyChain2 278 7920, 15562, 23204, 30846, 38488, 46130, 53772 Etrolizuab_LightChain1 279 7921, 15563, 23205, 30847, 38489, 46131, 53773 Etrolizumab_HeavyChain1 280 7922, 15564, 23206, 30848, 38490, 46132, 53774 Etrolizumab_LightChain1 281 7923, 15565, 23207, 30849, 38491, 46133, 53775 Evinacumab_HeavyChain1 282 7924, 15566, 23208, 30850, 38492, 46134, 53776 Evinacumab_LightChain1 283 7925, 15567, 23209, 30851, 38493, 46135, 53777 Evolocumab_HeavyChain1 284 7926, 15568, 23210, 30852, 38494, 46136, 53778 Evolocumab_LightChain1 285 7927, 15569, 23211, 30853, 38495, 46137, 53779 Exbivirumab_HeavyChain1 286 7928, 15570, 23212, 30854, 38496, 46138, 53780 Exbivirumab_LightChain1 287 7929, 15571, 23213, 30855, 38497, 46139, 53781 Farletuzumab_HeavyChain1 288 7930, 15572, 23214, 30856, 38498, 46140, 53782 Farletuzumab_LightChain1 289 7931, 15573, 23215, 30857, 38499, 46141, 53783 Fasinumab_HeavyChain1 290 7932, 15574, 23216, 30858, 38500, 46142, 53784 Fasinumab_LightChain1 291 7933, 15575, 23217, 30859, 38501, 46143, 53785 Fezakinumab_HeavyChain1 292 7934, 15576, 23218, 30860, 38502, 46144, 53786 Fezakinumab_LightChain1 293 7935, 15577, 23219, 30861, 38503, 46145, 53787 FG-3019_HeavyChain1 294 7936, 15578, 23220, 30862, 38504, 46146, 53788 FG-3019_LightChain1 295 7937, 15579, 23221, 30863, 38505, 46147, 53789 Fibatuzumab_HeavyChain1 296 7938, 15580, 23222, 30864, 38506, 46148, 53790 Fibatuzumab_LightChain1 297 7939, 15581, 23223, 30865, 38507, 46149, 53791 Ficlatuzumab_HeavyChain1 298 7940, 15582, 23224, 30866, 38508, 46150, 53792 Ficlatuzumab_HeavyChain 299 7941, 15583, 23225, 30867, 38509, 46151, 53793 Ficlatuzumab_LightChain1 300 7942, 15584, 23226, 30868, 38510, 46152, 53794 Figitumumab_HeavyChain1 301 7943, 15585, 23227, 30869, 38511, 46153, 53795 Figitumumab_LightChain1 302 7944, 15586, 23228, 30870, 38512, 46154, 53796 Firivumab_HeavyChain1 303 7945, 15587, 23229, 30871, 38513, 46155, 53797 Firivumab_LightChain1 304 7946, 15588, 23230, 30872, 38514, 46156, 53798 Flanvotumab_HeavyChain1 305 7947, 15589, 23231, 30873, 38515, 46157, 53799 Flanvotumab_LightChain1 306 7948, 15590, 23232, 30874, 38516, 46158, 53800 Fletikumab_HeavyChain1 307 7949, 15591, 23233, 30875, 38517, 46159, 53801 Fletikumab_LightChain1 308 7950, 15592, 23234, 30876, 38518, 46160, 53802 Fontolizumab_HeavyChain1 309 7951, 15593, 23235, 30877, 38519, 46161, 53803 Fontolizumab_LightChain1 310 7952, 15594, 23236, 30878, 38520, 46162, 53804 Foralumab_HeavyChain1 311 7953, 15595, 23237, 30879, 38521, 46163, 53805 Foralumab_LightChain1 312 7954, 15596, 23238, 30880, 38522, 46164, 53806 Foravirumab_HeavyChain1 313 7955, 15597, 23239, 30881, 38523, 46165, 53807 Foravirumab_HeavyChain 314 7956, 15598, 23240, 30882, 38524, 46166, 53808 Foravirumab_LightChain1 315 7957, 15599, 23241, 30883, 38525, 46167, 53809 Fresolimumab_HeavyChain1 316 7958, 15600, 23242, 30884, 38526, 46168, 53810 Fresolimumab_LightChain1 317 7959, 15601, 23243, 30885, 38527, 46169, 53811 Fulranumab_HeavyChain1 318 7960, 15602, 23244, 30886, 38528, 46170, 53812 Fulranumab_LightChain1 319 7961, 15603, 23245, 30887, 38529, 46171, 53813 Futuximab_HeavyChain1 320 7962, 15604, 23246, 30888, 38530, 46172, 53814 Futuximab_LightChain1 321 7963, 15605, 23247, 30889, 38531, 46173, 53815 Galcanezumab_HeavyChain1 322 7964, 15606, 23248, 30890, 38532, 46174, 53816 Galcanezumab_LightChain1 323 7965, 15607, 23249, 30891, 38533, 46175, 53817 Galiximab_HeavyChain1 324 7966, 15608, 23250, 30892, 38534, 46176, 53818 Galiximab_LightChain1 325 7967, 15609, 23251, 30893, 38535, 46177, 53819 Ganitumab_HeavyChain1 326 7968, 15610, 23252, 30894, 38536, 46178, 53820 Ganitumab_LightChain1 327 7969, 15611, 23253, 30895, 38537, 46179, 53821 Gantenerumab_HeavyChain1 328 7970, 15612, 23254, 30896, 38538, 46180, 53822 Gantenerumab_LightChain1 329 7971, 15613, 23255, 30897, 38539, 46181, 53823 Gemtuzumab_HeavyChain1 330 7972, 15614, 23256, 30898, 38540, 46182, 53824 Gemtuzumab_HeavyChain2 331 7973, 15615, 23257, 30899, 38541, 46183, 53825 Gemtuzumab_LightChain2 332 7974, 15616, 23258, 30900, 38542, 46184, 53826 Gemtuzumab_ozogamicin_LightChain1 333 7975, 15617, 23259, 30901, 38543, 46185, 53827 Gevokizumab_HeavyChain1 334 7976, 15618, 23260, 30902, 38544, 46186, 53828 Gevokizumab_LightChain1 335 7977, 15619, 23261, 30903, 38545, 46187, 53829 Girentuximab_HeavyChain1 336 7978, 15620, 23262, 30904, 38546, 46188, 53830 Girentuximab_LightChain1 337 7979, 15621, 23263, 30905, 38547, 46189, 53831 Glembatumumab_HeavyChain1 338 7980, 15622, 23264, 30906, 38548, 46190, 53832 Glembatumumab_LightChain1 339 7981, 15623, 23265, 30907, 38549, 46191, 53833 Goilixiab_HeavyChain1 340 7982, 15624, 23266, 30908, 38550, 46192, 53834 Goilixiab_LightChain1 341 7983, 15625, 23267, 30909, 38551, 46193, 53835 Guselkumab_HeavyChain1 342 7984, 15626, 23268, 30910, 38552, 46194, 53836 Guselkumab_LightChain1 343 7985, 15627, 23269, 30911, 38553, 46195, 53837 HuMab-001_HeavyChain_VDJ-Region 344 7986, 15628, 23270, 30912, 38554, 46196, 53838 HuMab-001_LightChain_VJ-Region 345 7987, 15629, 23271, 30913, 38555, 46197, 53839 HuMab-005_HeavyChain_gamma-Chain_VDJ-Region 346 7988, 15630, 23272, 30914, 38556, 46198, 53840 HuMab-005_LightChain_VJ-Region 347 7989, 15631, 23273, 30915, 38557, 46199, 53841 HuMab-006_HeavyChain_VDJ-Region 348 7990, 15632, 23274, 30916, 38558, 46200, 53842 HuMab-006_LightChain_VJ-Region 349 7991, 15633, 23275, 30917, 38559, 46201, 53843 HuMab-019_HeavyChain_VDJ-Region 350 7992, 15634, 23276, 30918, 38560, 46202, 53844 HuMab-021_HeavyChain_VDJ-Region 351 7993, 15635, 23277, 30919, 38561, 46203, 53845 HuMab-021_LightChain_VJ-Region 352 7994, 15636, 23278, 30920, 38562, 46204, 53846 HuMab-025_HeavyChain_VDJ-Region 353 7995, 15637, 23279, 30921, 38563, 46205, 53847 HuMab-025_LightChain_VJ-Region 354 7996, 15638, 23280, 30922, 38564, 46206, 53848 HuMab-027_HeavyChain_VDJ-Region 355 7997, 15639, 23281, 30923, 38565, 46207, 53849 HuMab-032_HeavyChain_VDJ-Region 356 7998, 15640, 23282, 30924, 38566, 46208, 53850 HuMab-032_LightChain_VJ-Region 357 7999, 15641, 23283, 30925, 38567, 46209, 53851 HuMab-033_HeavyChain_VDJ-Region 358 8000, 15642, 23284, 30926, 38568, 46210, 53852 HuMab-035_HeavyChain_VDJ-Region 359 8001, 15643, 23285, 30927, 38569, 46211, 53853 HuMab-036_HeavyChain_VDJ-Region 360 8002, 15644, 23286, 30928, 38570, 46212, 53854 HuMab-036_LightChain_VJ-Region 361 8003, 15645, 23287, 30929, 38571, 46213, 53855 HuMab-041_HeavyChain_VDJ-Region 362 8004, 15646, 23288, 30930, 38572, 46214, 53856 HuMab-044_HeavyChain_VDJ-Region 363 8005, 15647, 23289, 30931, 38573, 46215, 53857 HuMab-049_HeavyChain_VDJ-Region 364 8006, 15648, 23290, 30932, 38574, 46216, 53858 HuMab-049_LightChain_VJ-Region 365 8007, 15649, 23291, 30933, 38575, 46217, 53859 HuMab-050_HeavyChain_VDJ-Region 366 8008, 15650, 23292, 30934, 38576, 46218, 53860 HuMab-050_LightChain_VJ-Region 367 8009, 15651, 23293, 30935, 38577, 46219, 53861 HuMab-054_HeavyChain_VDJ-Region 368 8010, 15652, 23294, 30936, 38578, 46220, 53862 HuMab-054_LightChain_VJ-Region 369 8011, 15653, 23295, 30937, 38579, 46221, 53863 HuMab-055_HeavyChain_VDJ-Region 370 8012, 15654, 23296, 30938, 38580, 46222, 53864 HuMab-059_HeavyChain_VDJ-Region 371 8013, 15655, 23297, 30939, 38581, 46223, 53865 HuMab-059_LightChain_VJ-Region 372 8014, 15656, 23298, 30940, 38582, 46224, 53866 HuMab-060_HeavyChain_VDJ-Region 373 8015, 15657, 23299, 30941, 38583, 46225, 53867 HuMab-060_LightChain_VJ-Region 374 8016, 15658, 23300, 30942, 38584, 46226, 53868 HuMab-067_HeavyChain_VDJ-Region 375 8017, 15659, 23301, 30943, 38585, 46227, 53869 HuMab-072_HeavyChain_VDJ-Region 376 8018, 15660, 23302, 30944, 38586, 46228, 53870 HuMab-072_LightChain_VJ-Region 377 8019, 15661, 23303, 30945, 38587, 46229, 53871 HuMab-084_HeavyChain_VDJ-Region 378 8020, 15662, 23304, 30946, 38588, 46230, 53872 HuMab-084_LightChain_VJ-Region 379 8021, 15663, 23305, 30947, 38589, 46231, 53873 HuMab-091_HeavyChain_VDJ-Region 380 8022, 15664, 23306, 30948, 38590, 46232, 53874 HuMab-091_LightChain_VJ-Region 381 8023, 15665, 23307, 30949, 38591, 46233, 53875 HuMab-093_HeavyChain_VDJ-Region 382 8024, 15666, 23308, 30950, 38592, 46234, 53876 HuMab-098_HeavyChain_VDJ-Region 383 8025, 15667, 23309, 30951, 38593, 46235, 53877 HuMab-098_LightChain_VJ-Region 384 8026, 15668, 23310, 30952, 38594, 46236, 53878 HuMab-100_HeavyChain_VDJ-Region 385 8027, 15669, 23311, 30953, 38595, 46237, 53879 HuMab-106_HeavyChain_VDJ-Region 386 8028, 15670, 23312, 30954, 38596, 46238, 53880 HuMab-106_LightChain_VJ-Region 387 8029, 15671, 23313, 30955, 38597, 46239, 53881 HuMab_10F8_HeavyChain_V-Region 388 8030, 15672, 23314, 30956, 38598, 46240, 53882 HuMab_10F8_HeavyChain_V-Region_Precursor 389 8031, 15673, 23315, 30957, 38599, 46241, 53883 HuMab_10F8_LightChain_V-Region 390 8032, 15674, 23316, 30958, 38600, 46242, 53884 HuMab_10F8_LightChain_V-Region_Precursor 391 8033, 15675, 23317, 30959, 38601, 46243, 53885 HuMab-111_HeavyChain_VDJ-Region 392 8034, 15676, 23318, 30960, 38602, 46244, 53886 HuMab-111_LightChain_VJ-Region 393 8035, 15677, 23319, 30961, 38603, 46245, 53887 HuMab-123_HeavyChain_VDJ-Region 394 8036, 15678, 23320, 30962, 38604, 46246, 53888 HuMab-123_LightChain_VJ-Region 395 8037, 15679, 23321, 30963, 38605, 46247, 53889 HuMab-124_HeavyChain_VDJ-Region 396 8038, 15680, 23322, 30964, 38606, 46248, 53890 HuMab-125_HeavyChain_VDJ-Region 397 8039, 15681, 23323, 30965, 38607, 46249, 53891 HuMab-125_LightChain_VJ-Region 398 8040, 15682, 23324, 30966, 38608, 46250, 53892 HuMab-127_HeavyChain_VDJ-Region 399 8041, 15683, 23325, 30967, 38609, 46251, 53893 HuMab-127_LightChain_VJ-Region 400 8042, 15684, 23326, 30968, 38610, 46252, 53894 HuMab-129_HeavyChain_VDJ-Region 401 8043, 15685, 23327, 30969, 38611, 46253, 53895 HuMab-129_LightChain_VJ-Region 402 8044, 15686, 23328, 30970, 38612, 46254, 53896 HuMab-132_HeavyChain_VDJ-Region 403 8045, 15687, 23329, 30971, 38613, 46255, 53897 HuMab-132_LightChain_VJ-Region 404 8046, 15688, 23330, 30972, 38614, 46256, 53898 HuMab-143_HeavyChain_VDJ-Region 405 8047, 15689, 23331, 30973, 38615, 46257, 53899 HuMab-143_LightChain_VJ-Region 406 8048, 15690, 23332, 30974, 38616, 46258, 53900 HuMab-150_HeavyChain_VDJ-Region 407 8049, 15691, 23333, 30975, 38617, 46259, 53901 HuMab-150_LightChain_VJ-Region 408 8050, 15692, 23334, 30976, 38618, 46260, 53902 HuMab-152_HeavyChain_VDJ-Region 409 8051, 15693, 23335, 30977, 38619, 46261, 53903 HuMab-152_LightChain_VJ-Region 410 8052, 15694, 23336, 30978, 38620, 46262, 53904 HuMab-153_HeavyChain_VDJ-Region 411 8053, 15695, 23337, 30979, 38621, 46263, 53905 HuMab-153_LightChain_VJ-Region 412 8054, 15696, 23338, 30980, 38622, 46264, 53906 HuMab-159_HeavyChain_VDJ-Region 413 8055, 15697, 23339, 30981, 38623, 46265, 53907 HuMab-159_LightChain_VJ-Region 414 8056, 15698, 23340, 30982, 38624, 46266, 53908 HuMab-160_HeavyChain_VDJ-Region 415 8057, 15699, 23341, 30983, 38625, 46267, 53909 HuMab-160_LightChain_VJ-Region 416 8058, 15700, 23342, 30984, 38626, 46268, 53910 HuMab-162_HeavyChain_VDJ-Region 417 8059, 15701, 23343, 30985, 38627, 46269, 53911 HuMab-162_LightChain_VJ-Region 418 8060, 15702, 23344, 30986, 38628, 46270, 53912 HuMab-163_HeavyChain_VDJ-Region 419 8061, 15703, 23345, 30987, 38629, 46271, 53913 HuMab-163_LightChain_VJ-Region 420 8062, 15704, 23346, 30988, 38630, 46272, 53914 HuMab-166_HeavyChain_VDJ-Region 421 8063, 15705, 23347, 30989, 38631, 46273, 53915 HuMab-166_LightChain_VJ-Region 422 8064, 15706, 23348, 30990, 38632, 46274, 53916 HuMab-167_HeavyChain_VDJ-Region 423 8065, 15707, 23349, 30991, 38633, 46275, 53917 HuMab-169_HeavyChain_VDJ-Region 424 8066, 15708, 23350, 30992, 38634, 46276, 53918 HuMab-169_LightChain_VJ-Region 425 8067, 15709, 23351, 30993, 38635, 46277, 53919 HuMab-708_HeavyChain_VH-Region 426 8068, 15710, 23352, 30994, 38636, 46278, 53920 HuMab-708_HeavyChain_V-Region 427 8069, 15711, 23353, 30995, 38637, 46279, 53921 HuMab-708_LightChain_VL-Region 428 8070, 15712, 23354, 30996, 38638, 46280, 53922 HuMab-708_LightChain_V-Region 429 8071, 15713, 23355, 30997, 38639, 46281, 53923 huMAb-anti-MSP10.1_LightChain_VJ-Region 430 8072, 15714, 23356, 30998, 38640, 46282, 53924 huMAb-anti-MSP10.2_LightChain_VJ-Region 431 8073, 15715, 23357, 30999, 38641, 46283, 53925 HUMAB-Clone_18_VJ-Region 432 8074, 15716, 23358, 31000, 38642, 46284, 53926 HUMAB-Clone_22_VJ-Region 433 8075, 15717, 23359, 31001, 38643, 46285, 53927 HuMab-L612_μChain_VDJ-Region_Precursor 434 8076, 15718, 23360, 31002, 38644, 46286, 53928 HuMab_LC5002-002_LightChain_V-Region 435 8077, 15719, 23361, 31003, 38645, 46287, 53929 HuMab_LC5002-002_gamma1-Chain_V-Region 436 8078, 15720, 23362, 31004, 38646, 46288, 53930 HuMab_LC5002-003_LightChain_V-Region 437 8079, 15721, 23363, 31005, 38647, 46289, 53931 HuMab_LC5002-003_gamma1-Chain_V-Region 438 8080, 15722, 23364, 31006, 38648, 46290, 53932 HuMab_LC5002-005_LightChain_V-Region 439 8081, 15723, 23365, 31007, 38649, 46291, 53933 HuMab_LC5002-005_gamma1-Chain_V-Region 440 8082, 15724, 23366, 31008, 38650, 46292, 53934 HuMab_LC5002-007_LightChain_V-Region 441 8083, 15725, 23367, 31009, 38651, 46293, 53935 HuMab_LC5002-007_gamma1-Chain_V-Region 442 8084, 15726, 23368, 31010, 38652, 46294, 53936 HuMab_LC5002-018_gamma1-Chain_V-Region 443 8085, 15727, 23369, 31011, 38653, 46295, 53937 Ibalizumab_HeavyChain1 444 8086, 15728, 23370, 31012, 38654, 46296, 53938 Ibalizumab_LightChain1 445 8087, 15729, 23371, 31013, 38655, 46297, 53939 Ibritumomab_tiuxetan_HeavyChain 446 8088, 15730, 23372, 31014, 38656, 46298, 53940 Ibritumomab_tiuxetan_LightChain 447 8089, 15731, 23373, 31015, 38657, 46299, 53941 Icrucumab_HeavyChain1 448 8090, 15732, 23374, 31016, 38658, 46300, 53942 Icrucumab_LightChain1 449 8091, 15733, 23375, 31017, 38659, 46301, 53943 Idarucizumab_HeavyChain1 450 8092, 15734, 23376, 31018, 38660, 46302, 53944 Idarucizumab_LightChain1 451 8093, 15735, 23377, 31019, 38661, 46303, 53945 Igatuzuab_HeavyChain1 452 8094, 15736, 23378, 31020, 38662, 46304, 53946 Igatuzuab_LightChain1 453 8095, 15737, 23379, 31021, 38663, 46305, 53947 IGF-IR_HUMAB-1A_HeavyChain 454 8096, 15738, 23380, 31022, 38664, 46306, 53948 IGF-IR_HUMAB-23_HeavyChain 455 8097, 15739, 23381, 31023, 38665, 46307, 53949 IGF-IR_HUMAB-23_LightChain 456 8098, 15740, 23382, 31024, 38666, 46308, 53950 IGF-IR_HUMAB-8_HeavyChain 457 8099, 15741, 23383, 31025, 38667, 46309, 53951 IGF-IR_HUMAB-8_LightChain 458 8100, 15742, 23384, 31026, 38668, 46310, 53952 ImAb1_LightChain 459 8101, 15743, 23385, 31027, 38669, 46311, 53953 ImAb1_gamma1-Chain 460 8102, 15744, 23386, 31028, 38670, 46312, 53954 Imalumab_HeavyChain1 461 8103, 15745, 23387, 31029, 38671, 46313, 53955 Imalumab_LightChain1 462 8104, 15746, 23388, 31030, 38672, 46314, 53956 Imgatuzumab_HeavyChain1 463 8105, 15747, 23389, 31031, 38673, 46315, 53957 Imgatuzumab_LightChain1 464 8106, 15748, 23390, 31032, 38674, 46316, 53958 Inclacumab_HeavyChain1 465 8107, 15749, 23391, 31033, 38675, 46317, 53959 Inclacumab_LightChain1 466 8108, 15750, 23392, 31034, 38676, 46318, 53960 Indatuximab_ravtansine_HeavyChain1 467 8109, 15751, 23393, 31035, 38677, 46319, 53961 Indatuximab_ravtansine_LightChain1 468 8110, 15752, 23394, 31036, 38678, 46320, 53962 Indusatumab_vedotin_HeavyChain1 469 8111, 15753, 23395, 31037, 38679, 46321, 53963 Indusatumab_vedotin_LightChain1 470 8112, 15754, 23396, 31038, 38680, 46322, 53964 Inebilizumab_HeavyChain1 471 8113, 15755, 23397, 31039, 38681, 46323, 53965 Inebilizumab_LightChain1 472 8114, 15756, 23398, 31040, 38682, 46324, 53966 Insulin_peglispro_Fragment1 473 8115, 15757, 23399, 31041, 38683, 46325, 53967 Insulin_peglispro_Fragment2 474 8116, 15758, 23400, 31042, 38684, 46326, 53968 Interferon_beta-1b_chain1 475 8117, 15759, 23401, 31043, 38685, 46327, 53969 Intetumumab_HeavyChain1 476 8118, 15760, 23402, 31044, 38686, 46328, 53970 Intetumumab_LightChain1 477 8119, 15761, 23403, 31045, 38687, 46329, 53971 Iodine_(1241)_Girentuximab_HeavyChain1 478 8120, 15762, 23404, 31046, 38688, 46330, 53972 Iodine_(1241)_Girentuximab_LightChain1 479 8121, 15763, 23405, 31047, 38689, 46331, 53973 Iodine_(1311)_Derlotuxiab_biotin_HeavyChain1 480 8122, 15764, 23406, 31048, 38690, 46332, 53974 Iodine_(1311)_Derlotuxiab_biotin_LightChain1 481 8123, 15765, 23407, 31049, 38691, 46333, 53975 Iodine_(1311)_Derlotuximab_biotin_HeavyChain1 482 8124, 15766, 23408, 31050, 38692, 46334, 53976 Iodine_(1311)_Derlotuximab_biotin_LightChain1 483 8125, 15767, 23409, 31051, 38693, 46335, 53977 Ipilimumab_HeavyChain 484 8126, 15768, 23410, 31052, 38694, 46336, 53978 Ipilimumab_LightChain 485 8127, 15769, 23411, 31053, 38695, 46337, 53979 Iratumumab_HeavyChain1 486 8128, 15770, 23412, 31054, 38696, 46338, 53980 Iratumumab_LightChain1 487 8129, 15771, 23413, 31055, 38697, 46339, 53981 Isatuximab_HeavyChain1 488 8130, 15772, 23414, 31056, 38698, 46340, 53982 Isatuximab_LightChain1 489 8131, 15773, 23415, 31057, 38699, 46341, 53983 Itolizumab_HeavyChain1 490 8132, 15774, 23416, 31058, 38700, 46342, 53984 Itolizumab_LightChain1 491 8133, 15775, 23417, 31059, 38701, 46343, 53985 Ixekizumab_HeavyChain1 492 8134, 15776, 23418, 31060, 38702, 46344, 53986 Ixekizumab_LightChain1 493 8135, 15777, 23419, 31061, 38703, 46345, 53987 Labetuzumab_govitecan_HeavyChain1 494 8136, 15778, 23420, 31062, 38704, 46346, 53988 Labetuzumab_govitecan_LightChain1 495 8137, 15779, 23421, 31063, 38705, 46347, 53989 Lambrolizumab_HeavyChain1 496 8138, 15780, 23422, 31064, 38706, 46348, 53990 Lambrolizumab_LightChain1 497 8139, 15781, 23423, 31065, 38707, 46349, 53991 Lampalizumab_HeavyChain1 498 8140, 15782, 23424, 31066, 38708, 46350, 53992 Lampalizumab_LightChain1 499 8141, 15783, 23425, 31067, 38709, 46351, 53993 Lanadelumab_HeavyChain1 500 8142, 15784, 23426, 31068, 38710, 46352, 53994 Lanadelumab_LightChain1 501 8143, 15785, 23427, 31069, 38711, 46353, 53995 Landogrozumab_HeavyChain1 502 8144, 15786, 23428, 31070, 38712, 46354, 53996 Landogrozumab_LightChain1 503 8145, 15787, 23429, 31071, 38713, 46355, 53997 Laprituximab_emtansine_HeavyChain1 504 8146, 15788, 23430, 31072, 38714, 46355, 53998 Laprituximab_emtansine_LightChain1 505 8147, 15789, 23431, 31073, 38715, 46357, 53999 Lealesoab_HeavyChain1 506 8148, 15790, 23432, 31074, 38716, 46358, 54000 Lealesoab_LightChain1 507 8149, 15791, 23433, 31075, 38717, 46359, 54001 Lebrikizumab_HeavyChain1 508 8150, 15792, 23434, 31076, 38718, 46360, 54002 Lebrikizumab_LightChain1 509 8151, 15793, 23435, 31077, 38719, 46361, 54003 Lenercept_chain1 510 8152, 15794, 23436, 31078, 38720, 46362, 54004 Lenzilumab_HeavyChain1 511 8153, 15795, 23437, 31079, 38721, 46363, 54005 Lenzilumab_LightChain1 512 8154, 15796, 23438, 31080, 38722, 46364, 54006 Lerdelimumab_HeavyChain1 513 8155, 15797, 23439, 31081, 38723, 46365, 54007 Lerdelimumab_LightChain1 514 8156, 15798, 23440, 31082, 38724, 46366, 54008 Lexatumumab_HeavyChain1 515 8157, 15799, 23441, 31083, 38725, 46367, 54009 Lexatumumab_HeavyChain 516 8158, 15800, 23442, 31084, 38726, 46368, 54010 Lexatumumab_LightChain1 517 8159, 15801, 23443, 31085, 38727, 46369, 54011 Lexatumumab_LightChain 518 8160, 15802, 23444, 31086, 38728, 46370, 54012 Libivirumab_HeavyChain1 519 8161, 15803, 23445, 31087, 38729, 46371, 54013 Libivirumab_LightChain1 520 8162, 15804, 23446, 31088, 38730, 46372, 54014 Lifastuzumab_HeavyChain 521 8163, 15805, 23447, 31089, 38731, 46373, 54015 Lifastuzumab_LightChain 522 8164, 15806, 23448, 31090, 38732, 46374, 54016 Lifastuzumab_vedotin_HeavyChain1 523 8165, 15807, 23449, 31091, 38733, 46375, 54017 Lifastuzumab_vedotin_LightChain1 524 8166, 15808, 23450, 31092, 38734, 46376, 54018 Ligelizumab_HeavyChain1 525 8167, 15809, 23451, 31093, 38735, 46377, 54019 Ligelizumab_LightChain1 526 8168, 15810, 23452, 31094, 38736, 46378, 54020 Lilotomab_HeavyChain1 527 8169, 15811, 23453, 31095, 38737, 46379, 54021 Lilotomab_LightChain1 528 8170, 15812, 23454, 31096, 38738, 46380, 54022 Lintuzumab_HeavyChain1 529 8171, 15813, 23455, 31097, 38739, 46381, 54023 Lintuzumab_LightChain1 530 8172, 15814, 23456, 31098, 38740, 46382, 54024 Lirilumab_HeavyChain1 531 8173, 15815, 23457, 31099, 38741, 46383, 54025 Lirilumab_LightChain1 532 8174, 15816, 23458, 31100, 38742, 46384, 54026 Lodelcizumab_HeavyChain1 533 8175, 15817, 23459, 31101, 38743, 46385, 54027 Lodelcizumab_LightChain1 534 8176, 15818, 23460, 31102, 38744, 46386, 54028 Lokivetmab_HeavyChain1 535 8177, 15819, 23461, 31103, 38745, 46387, 54029 Lokivetmab_LightChain1 536 8178, 15820, 23462, 31104, 38746, 46388, 54030 Lorvotuzumab_mertansine_HeavyChain1 537 8179, 15821, 23463, 31105, 38747, 46389, 54031 Lorvotuzumab_mertansine_LightChain1 538 8180, 15822, 23464, 31106, 38748, 46390, 54032 Lpathomab_VL 539 8181, 15823, 23465, 31107, 38749, 46391, 54033 Lpathomab_gamma1-Chain_VDJ-Region 540 8182, 15824, 23466, 31108, 38750, 46392, 54034 Lucatumumab_HeavyChain1 541 8183, 15825, 23467, 31109, 38751, 46393, 54035 Lucatumumab_LightChain1 542 8184, 15826, 23468, 31110, 38752, 46394, 54036 Lulizumab_pegol_LightChain1 543 8185, 15827, 23469, 31111, 38753, 46395, 54037 Lulizumab_pegol_LightChain 544 8186, 15828, 23470, 31112, 38754, 46396, 54038 Lumiliximab_HeavyChain1 545 8187, 15829, 23471, 31113, 38755, 46397, 54039 Lumiliximab_LightChain1 546 8188, 15830, 23472, 31114, 38756, 46398, 54040 Lumretuzumab_HeavyChain1 547 8189, 15831, 23473, 31115, 38757, 46399, 54041 Lumretuzumab_LightChain1 548 8190, 15832, 23474, 31116, 38758, 46400, 54042 Lutetium_(177Lu)_lilotomab_satetraxetan_HeavyChain1 549 8191, 15833, 23475, 31117, 38759, 46401, 54043 Lutetium_(177Lu)_lilotomab_satetraxetan_LightChain1 550 8192, 15834, 23476, 31118, 38760, 46402, 54044 Margetuximab_HeavyChain1 551 8193, 15835, 23477, 31119, 38761, 46403, 54045 Margetuximab_LightChain1 552 8194, 15836, 23478, 31120, 38762, 46404, 54046 Marzeptacog_alfa_HeavyChain1 553 8195, 15837, 23479, 31121, 38763, 46405, 54047 Marzeptacog_alfa_LightChain1 554 8196, 15838, 23480, 31122, 38764, 46406, 54048 Matuzumab_HeavyChain1_variant_3c08_H 555 8197, 15839, 23481, 31123, 38765, 46407, 54049 Matuzumab_HeavyChain1_variant_3c09_C 556 8198, 15840, 23482, 31124, 38766, 46408, 54050 Matuzumab_LightChain1_variant_3c08_L 557 8199, 15841, 23483, 31125, 38767, 46409, 54051 Matuzumab_LightChain1_variant_3c09_B 558 8200, 15842, 23484, 31126, 38768, 46410, 54052 Mavrilimumab_HeavyChain1 559 8201, 15843, 23485, 31127, 38769, 46411, 54053 Mavrilimumab_LightChain1 560 8202, 15844, 23486, 31128, 38770, 49412, 54054 MDX-1303_HeavyChain1 561 8203, 15845, 23487, 31129, 38771, 46413, 54055 MDX-1303_LightChain1 562 8204, 15846, 23488, 31130, 38772, 46414, 54056 Mepolizumab_HeavyChain1 563 8205, 15847, 23489, 31131, 38773, 46415, 54057 Mepolizumab_LightChain1 564 8206, 15848, 23490, 31132, 38774, 46416, 54058 Metelimumab_HeavyChain1 565 8207, 15849, 23491, 31133, 38775, 46417, 54059 Metelimumab_LightChain1 566 8208, 15850, 23492, 31134, 38776, 46418, 54060 Milatuzumab_HeavyChain1 567 8209, 15851, 23493, 31135, 38777, 46419, 54061 Milatuzumab_LightChain1 568 8210, 15852, 23494, 31136, 38778, 46420, 54062 Mirvetuximab_HeavyChain1 569 8211, 15853, 23495, 31137, 38779, 46421, 54063 Mirvetuximab_LightChain1 570 8212, 15854, 23496, 31138, 38780, 46422, 54064 Modotuximab_HeavyChain1 571 8213, 15855, 23497, 31139, 38781, 46423, 54065 Modotuximab_LightChain1 572 8214, 15856, 23498, 31140, 38782, 46424, 54066 Mogamulizumab_HeavyChain1 573 8215, 15857, 23499, 31141, 38783, 46425, 54067 Mogamulizumab_LightChain1 574 8216, 15858, 23500, 31142, 38784, 46426, 54068 Monalizumab_HeavyChain1 575 8217, 15859, 23501, 31143, 38785, 46427, 54069 Monalizumab_LightChain1 576 8218, 15860, 23502, 31144, 38786, 46428, 54070 Motavizumab_HeavyChain 577 8219, 15861, 23503, 31145, 38787, 46429, 54071 Motavizumab_HeavyChain_variant 578 8220, 15862, 23504, 31146, 38788, 46430, 54072 Motavizumab_LightChain 579 8221, 15863, 23505, 31147, 38789, 46431, 54073 Motavizumab_LightChain_variant 580 8222, 15864, 23506, 31148, 38790, 46432, 54074 Moxetumomab_pasudotox_HeavyChain1 581 8223, 15865, 23507, 31149, 38791, 46433, 54075 Moxetumomab_pasudotox_LightChain1 582 8224, 15866, 23508, 31150, 38792, 46434, 54076 Muromonab-CD3_HeavyChain 583 8225, 15867, 23509, 31151, 38793, 46435, 54077 Muromonab-CD3_LightChain 584 8226, 15868, 23510, 31152, 38794, 46436, 54078 Namilumab_HeavyChain1 585 8227, 15869, 23511, 31153, 38795, 46437, 54079 Namilumab_LightChain1 586 8228, 15870, 23512, 31154, 38796, 46438, 54080 Naptumomab_estafenatox_HeavyChain 587 8229, 15871, 23513, 31155, 38797, 46439, 54081 Naptumomab_estafenatox_LightChain 588 8230, 15872, 23514, 31156, 38798, 46440, 54082 Narnatumab_HeavyChain1 589 8231, 15873, 23515, 31157, 38799, 46441, 54083 Narnatumab_LightChain1 590 8232, 15874, 23516, 31158, 38800, 46442, 54084 Natalizumab_HeavyChain1 591 8233, 15875, 23517, 31159, 38801, 46443, 54085 Natalizumab_LightChain1 592 8234, 15876, 23518, 31160, 38802, 46444, 54086 Navicixizumab_HeavyChain1 593 8235, 15877, 23519, 31161, 38803, 46445, 54087 Navicixizumab_HeavyChain2 594 8236, 15878, 23520, 31162, 38804, 46446, 54088 Navicixizumab_LightChain1 595 8237, 15879, 23521, 31163, 38805, 46447, 54089 Navivumab_HeavyChain1 596 8238, 15880, 23522, 31164, 38806, 46448, 54090 Navivumab_LightChain1 597 8239, 15881, 23523, 31165, 38807, 46449, 54091 Ndimab-varB_HeavyChain 598 8240, 15882, 23524, 31166, 38808, 46450, 54092 Ndimab-varB_LightChain 599 8241, 15883, 23525, 31167, 38809, 46451, 54093 Necitumumab_HeavyChain1 600 8242, 15884, 23526, 31168, 38810, 46452, 54094 Necitumumab_LightChain1 601 8243, 15885, 23527, 31169, 38811, 46453, 54095 Neliximab_HeavyChain_VH-Region 602 8244, 15886, 23528, 31170, 38812, 46454, 54096 Neliximab_HeavyChain_VH-Region_variant1 603 8245, 15887, 23529, 31171, 38813, 46455, 54097 Neliximab_LightChain_VL-Region 604 8246, 15888, 23530, 31172, 38814, 46456, 54098 Neliximab_LightChain_VL-Region_variant1 605 8247, 15889, 23531, 31173, 38815, 46457, 54099 Nemolizumab_HeavyChain1 606 8248, 15890, 23532, 31174, 38816, 46458, 54100 Nemolizumab_LightChain1 607 8249, 15891, 23533, 31175, 38817, 46459, 54101 Nesvacumab_HeavyChain1 608 8250, 15892, 23534, 31176, 38818, 46460, 54102 Nesvacumab_LightChain1 609 8251, 15893, 23535, 31177, 38819, 46461, 54103 Neuradiab_HeavyChain1 610 8252, 15894, 23536, 31178, 38820, 46462, 54104 Neuradiab_LightChain1 611 8253, 15895, 23537, 31179, 38821, 46463, 54105 Nimotuzumab_HeavyChain1 612 8254, 15896, 23538, 31180, 38822, 46464, 54106 Nimotuzumab_LightChain1 613 8255, 15897, 23539, 31181, 38823, 46465, 54107 Nivolumab_HeavyChain1 614 8256, 15898, 23540, 31182, 38824, 46466, 54108 Nivolumab_LightChain1 615 8257, 15899, 23541, 31183, 38825, 46467, 54109 Obiltoxaximab_HeavyChain1 616 8258, 15900, 23542, 31184, 38826, 46468, 54110 Obiltoxaximab_LightChain1 617 8259, 15901, 23543, 31185, 38827, 46469, 54111 Obinutuzumab_HeavyChain1 618 8260, 15902, 23544, 31186, 38828, 46470, 54112 Obinutuzumab_LightChain1 619 8261, 15903, 23545, 31187, 38829, 46471, 54113 Ocaratuzumab_HeavyChain1 620 8262, 15904, 23546, 31188, 38830, 46472, 54114 Ocaratuzumab_LightChain1 621 8263, 15905, 23547, 31189, 38831, 46473, 54115 Ocrelizumab_HeavyChain1 622 8264, 15906, 23548, 31190, 38832, 46474, 54116 Ocrelizumab_LightChain1 623 8265, 15907, 23549, 31191, 38833, 46475, 54117 Ofatumumab_HeavyChain1 624 8266, 15908, 23550, 31192, 38834, 46476, 54118 Ofatumumab_LightChain1 625 8267, 15909, 23551, 31193, 38835, 46477, 54119 Olaratumab_HeavyChain1 626 8268, 15910, 23552, 31194, 38836, 46478, 54120 Olaratumab_LightChain1 627 8269, 15911, 23553, 31195, 38837, 46479, 54121 Olizuab_HeavyChain1 628 8270, 15912, 23554, 31196, 38838, 46480, 54122 Olizuab_LightChain1 629 8271, 15913, 23555, 31197, 38839, 46481, 54123 Olokizumab_HeavyChain1 630 8272, 15914, 23556, 31198, 38840, 46482, 54124 Olokizumab_LightChain1 631 8273, 15915, 23557, 31199, 38841, 46483, 54125 Omalizumab_HeavyChain 632 8274, 15916, 23558, 31200, 38842, 46484, 54126 Omalizumab_LightChain 633 8275, 15917, 23559, 31201, 38843, 46485, 54127 Onartuzumab_HeavyChain1 634 8276, 15918, 23560, 31202, 38844, 46486, 54128 Onartuzumab_HeavyChain2 635 8277, 15919, 23561, 31203, 38845, 46487, 54129 Onartuzumab_LightChain1 636 8278, 15920, 23562, 31204, 38846, 46488, 54130 Ontuxizumab_HeavyChain1 637 8279, 15921, 23563, 31205, 38847, 46489, 54131 Ontuxizumab_LightChain1 638 8280, 15922, 23564, 31206, 38848, 46490, 54132 Opicinumab_HeavyChain1 639 8281, 15923, 23565, 31207, 38849, 46491, 54133 Opicinumab_LightChain1 640 8282, 15924, 23566, 31208, 38850, 46492, 54134 Oportuzumab_monatox_HeavyChain1 641 8283, 15925, 23567, 31209, 38851, 46493, 54135 Oportuzumab_monatox_SingleChain_variable_fragment 642 8284, 15926, 23568, 31210, 38852, 46494, 54136 Oreptacog_alfa_HeavyChain1 643 8285, 15927, 23569, 31211, 38853, 46495, 54137 Oreptacog_alfa_LightChain1 644 8286, 15928, 23570, 31212, 38854, 46496, 54138 Orticumab_HeavyChain1 645 8287, 15929, 23571, 31213, 38855, 46497, 54139 Orticumab_LightChain1 646 8288, 15930, 23572, 31214, 38856, 46498, 54140 Otelixizumab_HeavyChain1 647 8289, 15931, 23573, 31215, 38857, 46499, 54141 Otelixizumab_LightChain1 648 8290, 15932, 23574, 31216, 38858, 46500, 54142 Otlertuzumab_HeavyChain1 649 8291, 15933, 23575, 31217, 38859, 46501, 54143 Oxelumab_HeavyChain1 650 8292, 15934, 23576, 31218, 38860, 46502, 54144 Oxelumab_LightChain1 651 8293, 15935, 23577, 31219, 38861, 46503, 54145 Ozanezumab_HeavyChain1 652 8294, 15936, 23578, 31220, 38862, 49504, 54146 Ozanezumab_LightChain1 653 8295, 15937, 23579, 31221, 38863, 46505, 54147 Ozoralizumab_HeavyChain1 654 8296, 15938, 23580, 31222, 38864, 46506, 54148 Palivizumab_HeavyChain 655 8297, 15939, 23581, 31223, 38865, 46507, 54149 Palivizumab_LightChain 656 8298, 15940, 23582, 31224, 38866, 46508, 54150 Palivizumab_VH-Region 657 8299, 15941, 23583, 31225, 38867, 46509, 54151 Pamrevlumab_HeavyChain1 658 8300, 15942, 23584, 31226, 38868, 46510, 54152 Pamrevlumab_LightChain1 659 8301, 15943, 23585, 31227, 38869, 46511, 54153 Panitumumab_HeavyChain1 660 8302, 15944, 23586, 31228, 38870, 46512, 54154 Panitumumab_LightChain1 661 8303, 15945, 23587, 31229, 38871, 46513, 54155 Pankoab_HeavyChain1 662 8304, 15946, 23588, 31230, 38872, 46514, 54156 Pankoab_LightChain1 663 8305, 15947, 23589, 31231, 38873, 46515, 54157 Pankoab_LightChain2 664 8306, 15948, 23590, 31232, 38874, 46516, 54158 PankoMab_HeavyChain_VDJ-Region 665 8307, 15949, 23591, 31233, 38875, 46517, 54159 PankoMab_LightChain_VJ-Region 666 8308, 15950, 23592, 31234, 38876, 46518, 54160 Panobacumab_HeavyChain1 667 8309, 15951, 23593, 31235, 38877, 46519, 54161 Panobacumab_LightChain1 668 8310, 15952, 23594, 31236, 38878, 46520, 54162 Panobacumab_LightChain2 669 8311, 15953, 23595, 31237, 38879, 46521, 54163 Parsatuzumab_HeavyChain1 670 8312, 15954, 23596, 31238, 38880, 46522, 54164 Parsatuzumab_LightChain1 671 8313, 15955, 23597, 31239, 38881, 46523, 54165 Pascolizumab_HeavyChain1 672 8314, 15956, 23598, 31240, 38882, 46524, 54166 Pascolizumab_LightChain1 673 8315, 15957, 23599, 31241, 38883, 46525, 54167 Pasotuxizumab_HeavyChain1 674 8316, 15958, 23600, 31242, 38884, 46526, 54168 Pasotuxizumab_SingleChain 675 8317, 15959, 23601, 31243, 38885, 46527, 54169 Pateclizumab_HeavyChain1 676 8318, 15960, 23602, 31244, 38886, 46528, 54170 Pateclizumab_LightChain1 677 8319, 15961, 23603, 31245, 38887, 46529, 54171 Patritumab_HeavyChain1 678 8320, 15962, 23604, 31246, 38888, 46530, 54172 Patritumab_hinge-CH2—CH3 679 8321, 15963, 23605, 31247, 38889, 46531, 54173 Patritumab_LightChain1 680 8322, 15964, 23606, 31248, 38890, 46532, 54174 Pembrolizumab_HeavyChain1 681 8323, 15965, 23607, 31249, 38891, 46533, 54175 Pembrolizumab_LightChain1 682 8324, 15966, 23608, 31250, 38892, 46534, 54176 Perakizumab_HeavyChain1 683 8325, 15967, 23609, 31251, 38893, 46535, 54177 Perakizumab_LightChain1 684 8326, 15968, 23610, 31252, 38894, 46536, 54178 Pertuzuab_HeavyChain1 685 8327, 15969, 23611, 31253, 38895, 46537, 54179 Pertuzuab_LightChain1 686 8328, 15970, 23612, 31254, 38896, 46538, 54180 Pertuzumab_HeavyChain 687 8329, 15971, 23613, 31255, 38897, 46539, 54181 Pertuzumab_LightChain 688 8330, 15972, 23614, 31256, 38898, 46540, 54182 Pexelizumab_h5g1.1-scFv 689 8331, 15973, 23615, 31257, 38899, 46541, 54183 Pexelizumab_h5g1.1VHC_+_F_Heavy_Chain_V-Region 690 8332, 15974, 23616, 31258, 38900, 46542, 54184 Pexelizumab_h5g1.1VHC_+_F_Light_Chain_V-Region 691 8333, 15975, 23617, 31259, 38901, 46543, 54185 PF-05082566_HeavyChain1 692 8334, 15976, 23618, 31260, 38902, 46544, 54186 PF-05082568_LightChain1 693 8335, 15977, 23619, 31261, 38903, 46545, 54187 Pidilizumab_HeavyChain1 694 8336, 15978, 23620, 31262, 38904, 46546, 54188 Pidilizumab_LightChain1 695 8337, 15979, 23621, 31263, 38905, 46547, 54189 Pinatuzumab_vedotin_HeavyChain1 696 8338, 15980, 23622, 31264, 38906, 46548, 54190 Pinatuzumab_vedotin_LightChain1 697 8339, 15981, 23623, 31265, 38907, 46549, 54191 Placulumab_chain1 698 8340, 15982, 23624, 31266, 38908, 46550, 54192 Placulumab_HeavyChain1 699 8341, 15983, 23625, 31267, 38909, 46551, 54193 Plozalizumab_HeavyChain1 700 8342, 15984, 23626, 31268, 38910, 46552, 54194 Plozalizumab_LightChain1 701 8343, 15985, 23627, 31269, 38911, 46553, 54195 Pogalizumab_HeavyChain1 702 8344, 15986, 23628, 31270, 38912, 46554, 54196 Pogalizumab_LightChain1 703 8345, 15987, 23629, 31271, 38913, 46555, 54197 Polatuzumab_vedotin_HeavyChain1 704 8346, 15988, 23630, 31272, 38914, 46556, 54198 Polatuzumab_vedotin_LightChain1 705 8347, 15989, 23631, 31273, 38915, 46557, 54199 Ponezumab_HeavyChain1 706 8348, 15990, 23632, 31274, 38916, 46558, 54200 Ponezumab_LightChain1 707 8349, 15991, 23633, 31275, 38917, 46559, 54201 Pritoxaximab_HeavyChain1 708 8350, 15992, 23634, 31276, 38918, 46560, 54202 Pritoxaximab_LightChain1 709 8351, 15993, 23635, 31277, 38919, 46561, 54203 Pritumumab_HeavyChain1 710 8352, 15994, 23636, 31278, 38920, 46562, 54204 Pritumumab_LightChain1 711 8353, 15995, 23637, 31279, 38921, 46563, 54205 Quilizumab_HeavyChain1 712 8354, 15996, 23638, 31280, 38922, 46564, 54206 Quilizumab_LightChain1 713 8355, 15997, 23639, 31281, 38923, 46565, 54207 Racotumomab_HeavyChain1 714 8356, 15998, 23640, 31282, 38924, 46566, 54208 Racotumomab_LightChain1 715 8357, 15999, 23641, 31283, 38925, 46567, 54209 Racotumomab_scVH-VH′-VH_chain 716 8358, 16000, 23642, 31284, 38926, 46568, 54210 Radretumab_HeavyChain1 717 8359, 16001, 23643, 31285, 38927, 46569, 54211 Radretumab_j_chain 718 8360, 16002, 23644, 31286, 38928, 46570, 54212 Rafivirumab_HeavyChain1 719 8361, 16003, 23645, 31287, 38929, 46571, 54213 Rafivirumab_HeavyChain 720 8362, 16004, 23646, 31288, 38930, 46572, 54214 Rafivirumab_LightChain1 721 8363, 16005, 23647, 31289, 38931, 46573, 54215 Rafivirumab_LightChain 722 8364, 16006, 23648, 31290, 38932, 46574, 54216 Ralpancizumab_HeavyChain1 723 8365, 16007, 23649, 31291, 38933, 46575, 54217 Ralpancizumab_LightChain1 724 8366, 16008, 23650, 31292, 38934, 46576, 54218 Ramucirumab_HeavyChain1 725 8367, 16009, 23651, 31293, 38935, 46577, 54219 Ramucirumab_LightChain1 726 8368, 16010, 23652, 31294, 38936, 46578, 54220 Ranibiziuab_HeavyChain1 727 8369, 16011, 23653, 31295, 38937, 46579, 54221 Ranibiziuab_LightChain1 728 8370, 16012, 23654, 31296, 38938, 46580, 54222 Ranibizumab_fab_fragment 729 8371, 16013, 23655, 31297, 38939, 46581, 54223 Ranibizumab_HeavyChain 730 8372, 16014, 23656, 31298, 38940, 46582, 54224 Ranibizumab_LightChain 731 8373, 16015, 23657, 31299, 38941, 46583, 54225 Ranibizumab_LightChain_variant 732 8374, 16016, 23658, 31300, 38942, 46584, 54226 Refanezumab_HeavyChain1 733 8375, 16017, 23659, 31301, 38943, 46585, 54227 Refanezumab_LightChain1 734 8376, 16018, 23660, 31302, 38944, 46586, 54228 REGN2810_HeavyChain1 735 8377, 16019, 23661, 31303, 38945, 46587, 54229 REGN2810_LightChain1 736 8378, 16020, 23662, 31304, 38946, 46588, 54230 rhuMab_HER2(9CI)_LightChain 737 8379, 16021, 23663, 31305, 38947, 46589, 54231 rhuMab_HER2_HeavyChain 738 8380, 16022, 23664, 31306, 38948, 46590, 54232 rhuMab_HER2_LightChain 739 8381, 16023, 23665, 31307, 38949, 46591, 54233 rhuMab_HER2_LightChain_variant1 740 8382, 16024, 23666, 31308, 38950, 46592, 54234 rhuMab_HER2_LightChain_variant2 741 8383, 16025, 23667, 31309, 38951, 46593, 54235 rhuMab_HER2_LightChain_variant3 742 8384, 16026, 23668, 31310, 38952, 46594, 54236 rhuMab_HER2_LightChain_variant4 743 8385, 16027, 23669, 31311, 38953, 46595, 54237 rhuMab_HER2_LightChain_V-Region 744 8386, 16028, 23670, 31312, 38954, 46596, 54238 rhuMab_HER2_gamma1-Chain 745 8387, 16029, 23671, 31313, 38955, 46597, 54239 rhuMab_HER2_gamma1-Chain 746 8388, 16030, 23672, 31314, 38956, 46598, 54240 rhuMab_HER2_gamma1- 747 8389, 16031, 23673, 31315, 38957, 46599, 54241 Chain_rhuMab_HER2_LightChain_sc405 rhuMab_HER2_gamma1-Chain_variant1 748 8390, 16032, 23674, 31316, 38958, 46600, 54242 rhuMab_HER2_gamma1-Chain_variant2 749 8391, 16033, 23675, 31317, 38959, 46601, 54243 rhuMab_HER2_gamma1-Chain_variant3 750 8392, 16034, 23676, 31318, 38960, 46602, 54244 rhuMab_HER2_gamma1-Chain_V-Region 751 8393, 16035, 23677, 31319, 38961, 46603, 54245 rhuMab-VEGF_HeavyChain1 752 8394, 16036, 23678, 31320, 38962, 46604, 54246 rhuMab-VEGF_LightChain1 753 8395, 16037, 23679, 31321, 38963, 46605, 54247 rhuMAb-VEGF_LightChain 754 8396, 16038, 23680, 31322, 38964, 46606, 54248 rhuMAb-VEGF_LightChain_VG-Region 755 8397, 16039, 23681, 31323, 38965, 46607, 54249 rhuMAb-VEGF_gamma1-Chain 756 8398, 16040, 23682, 31324, 38966, 46608, 54250 rhuMAb-VEGF_gamma1-Chain_VDG-Region 757 8399, 16041, 23683, 31325, 38967, 46609, 54251 Rilotumumab_HeavyChain1 758 8400, 16042, 23684, 31326, 38968, 46610, 54252 Rilotumumab_LightChain1 759 8401, 16043, 23685, 31327, 38969, 46611, 54253 Rilotumumab_scFv-CH_chain 760 8402, 16044, 23686, 31328, 38970, 46612, 54254 Rinucumab_HeavyChain1 761 8403, 16045, 23687, 31329, 38971, 46613, 54255 Rinucumab_HeavyChain 762 8404, 16046, 23688, 31330, 38972, 46614, 54256 Rinucumab_LightChain1 763 8405, 16047, 23689, 31331, 38973, 46615, 54257 Risankizumab_HeavyChain1 764 8406, 16048, 23690, 31332, 38974, 46616, 54258 Risankizumab_LightChain1 765 8407, 16049, 23691, 31333, 38975, 46617, 54259 Rituximab_HeavyChain 766 8408, 16050, 23692, 31334, 38976, 46618, 54260 Rituximab_HeavyChain_variant 767 8409, 16051, 23693, 31335, 38977, 46619, 54261 Rituximab_LightChain 768 8410, 16052, 23694, 31336, 38978, 46620, 54262 Rivabazumab_pegol_HeavyChain1 769 8411, 16053, 23695, 31337, 38979, 46621, 54263 Rivabazumab_pegol_LightChain1 770 8412, 16054, 23696, 31338, 38980, 46622, 54264 Robatumumab_HeavyChain1 771 8413, 16055, 23697, 31339, 38981, 46623, 54265 Robatumumab_LightChain1 772 8414, 16056, 23698, 31340, 38982, 46624, 54266 Roledumab_HeavyChain1 773 8415, 16057, 23699, 31341, 38983, 46625, 54267 Roledumab_LightChain1 774 8416, 16058, 23700, 31342, 38984, 46626, 54268 Romosozumab_fab_fragment 775 8417, 16059, 23701, 31343, 38985, 46627, 54269 Romosozumab_HeavyChain1 776 8418, 16060, 23702, 31344, 38986, 46628, 54270 Romosozumab_LightChain1 777 8419, 16061, 23703, 31345, 38987, 46629, 54271 Rontalizuab_HeavyChain1 778 8420, 16062, 23704, 31346, 38988, 46630, 54272 Rontalizuab_LightChain1 779 8421, 16063, 23705, 31347, 38989, 46631, 54273 Rontalizumab_HeavyChain1 780 8422, 16064, 23706, 31348, 38990, 46632, 54274 Rontalizumab_LightChain1 781 8423, 16065, 23707, 31349, 38991, 46633, 54275 Rovalpituzumab_tesirine_HeavyChain1 782 8424, 16066, 23708, 31350, 38992, 46634, 54276 Rovalpituzumab_tesirine_LightChain1 783 8425, 16067, 23709, 31351, 38993, 46635, 54277 Rovelizumab_HeavyChain1 784 8426, 16068, 23710, 31352, 38994, 46636, 54278 Rovelizumab_LightChain1 785 8427, 16069, 23711, 31353, 38995, 46637, 54279 Ruplizumab_HeavyChain1 786 8428, 16070, 23712, 31354, 38996, 46638, 54280 Ruplizumab_LightChain1 787 8429, 16071, 23713, 31355, 38997, 46639, 54281 Sacituzumab_govitecan_HeavyChain1 788 8430, 16072, 23714, 31356, 38998, 46640, 54282 Sacituzumab_govitecan_LightChain1 789 8431, 16073, 23715, 31357, 38999, 46641, 54283 Samalizumab_HeavyChain1 790 8432, 16074, 23716, 31358, 39000, 46642, 54284 Samalizumab_LightChain1 791 8433, 16075, 23717, 31359, 39001, 46643, 54285 Sarilumab_HeavyChain1 792 8434, 16076, 23718, 31360, 39002, 46644, 54286 Sarilumab_LightChain1 793 8435, 16077, 23719, 31361, 39003, 46645, 54287 Satumomab_pendetide_HeavyChain 794 8436, 16078, 23720, 31362, 39004, 46646, 54288 Satumomab_pendetide_LightChain 795 8437, 16079, 23721, 31363, 39005, 46647, 54289 Secukinumab_HeavyChain1 796 8438, 16080, 23722, 31364, 39006, 46648, 54290 Secukinumab_LightChain1 797 8439, 16081, 23723, 31365, 39007, 46649, 54291 Seribantumab_HeavyChain1 798 8440, 16082, 23724, 31366, 39008, 46650, 54292 Seribantumab_LightChain1 799 8441, 16083, 23725, 31367, 39009, 46651, 54293 Setoxaximab_HeavyChain1 800 8442, 16084, 23726, 31368, 39010, 46652, 54294 Setoxaximab_LightChain1 801 8443, 16085, 23727, 31369, 39011, 46653, 54295 Sifalimumab_HeavyChain1 802 8444, 16086, 23728, 31370, 39012, 46654, 54296 Sifalimumab_LightChain1 803 8445, 16087, 23729, 31371, 39013, 46655, 54297 Siltuximab_HeavyChain1 804 8446, 16088, 23730, 31372, 39014, 46656, 54298 Siltuximab_LightChain1 805 8447, 16089, 23731, 31373, 39015, 46657, 54299 Simtuzumab_HeavyChain1 806 8448, 16090, 23732, 31374, 39016, 46658, 54300 Simtuzumab_LightChain1 807 8449, 16091, 23733, 31375, 39017, 46659, 54301 Sirukumab_HeavyChain1 808 8450, 16092, 23734, 31376, 39018, 46660, 54302 Sirukumab_LightChain1 809 8451, 16093, 23735, 31377, 39019, 46661, 54303 Sofituzumab_vedotin_HeavyChain1 810 8452, 16094, 23736, 31378, 39020, 46662, 54304 Sofituzumab_vedotin_LightChain1 811 8453, 16095, 23737, 31379, 39021, 46663, 54305 Solanezumab_HeavyChain1 812 8454, 16096, 23738, 31380, 39022, 46664, 54306 Solanezumab_HeavyChain 813 8455, 16097, 23739, 31381, 39023, 46665, 54307 Solanezumab_LightChain1 814 8456, 16098, 23740, 31382, 39024, 46666, 54308 Solitomab_HeavyChain1 815 8457, 16099, 23741, 31383, 39025, 46667, 54309 Solitomab_SingleChain 816 8458, 16100, 23742, 31384, 39026, 46668, 54310 Sonepcizumab_LightChain_Precursor 817 8459, 16101, 23743, 31385, 39027, 46669, 54311 Sonepcizumab_gamma1-Chain_Precursor 818 8460, 16102, 23744, 31386, 39028, 46670, 54312 Stamulumab_HeavyChain1 819 8461, 16103, 23745, 31387, 39029, 46671, 54313 Stamulumab_LightChain1 820 8462, 16104, 23746, 31388, 39030, 46672, 54314 Suptavumab_HeavyChain1 821 8463, 16105, 23747, 31389, 39031, 46673, 54315 Suptavumab_LightChain1 822 8464, 16106, 23748, 31390, 39032, 46674, 54316 Suvizumab_HeavyChain1 823 8465, 16107, 23749, 31391, 39033, 46675, 54317 Suvizumab_LightChain1 824 8466, 16108, 23750, 31392, 39034, 46676, 54318 Tabalumab_HeavyChain1 825 8467, 16109, 23751, 31393, 39035, 46677, 54319 Tabalumab_LightChain1 826 8468, 16110, 23752, 31394, 39036, 46678, 54320 Tacatuzuab_HeavyChain1 827 8469, 16111, 23753, 31395, 39037, 46679, 54321 Tacatuzuab_LightChain1 828 8470, 16112, 23754, 31396, 39038, 46680, 54322 Tadocizumab_fab_fragment_HeavyChain 829 8471, 16113, 23755, 31397, 39039, 46681, 54323 Tadocizumab_fab_fragment_LightChain 830 8472, 16114, 23756, 31398, 39040, 46682, 54324 Talizumab_HeavyChain1 831 8473, 16115, 23757, 31399, 39041, 46683, 54325 Talizumab_LightChain1 832 8474, 16116, 23758, 31400, 39042, 46684, 54326 Tamtuvetmab_HeavyChain1 833 8475, 16117, 23759, 31401, 39043, 46685, 54327 Tamtuvetmab_LightChain1 834 8476, 16118, 23760, 31402, 39044, 46686, 54328 Tanezumab_HeavyChain 835 8477, 16119, 23761, 31403, 39045, 46687, 54329 Tanezumab_LightChain 836 8478, 16120, 23762, 31404, 39046, 46688, 54330 Tarextumab_HeavyChain1 837 8479, 16121, 23763, 31405, 39047, 46689, 54331 Tarextumab_LightChain1 838 8480, 16122, 23764, 31406, 39048, 46690, 54332 Tefibazumab_HeavyChain1 839 8481, 16123, 23765, 31407, 39049, 46691, 54333 Tefibazumab_LightChain1 840 8482, 16124, 23766, 31408, 39050, 46692, 54334 Tenatumomab_HeavyChain1 841 8483, 16125, 23767, 31409, 39051, 46693, 54335 Tenatumomab_LightChain1 842 8484, 16126, 23768, 31410, 39052, 46694, 54336 Teneliximab_HeavyChain1 843 8485, 16127, 23769, 31411, 39053, 46695, 54337 Teneliximab_LightChain1 844 8486, 16128, 23770, 31412, 39054, 46696, 54338 Teplizumab_HeavyChain1 845 8487, 16129, 23771, 31413, 39055, 46697, 54339 Teplizumab_LightChain1 846 8488, 16130, 23772, 31414, 39056, 46698, 54340 Teprotumumab_HeavyChain1 847 8489, 16131, 23773, 31415, 39057, 46699, 54341 Teprotumumab_LightChain1 848 8490, 16132, 23774, 31416, 39058, 46700, 54342 Tesidolumab_HeavyChain1 849 8491, 16133, 23775, 31417, 39059, 46701, 54343 Tesidolumab_LightChain1 850 8492, 16134, 23776, 31418, 39060, 46702, 54344 Tezepelumab_HeavyChain1 851 8493, 16135, 23777, 31419, 39061, 46703, 54345 Tezepelumab_LightChain1 852 8494, 16136, 23778, 31420, 39162, 46704, 54346 ThioMAb-chMA79b-HC(A118C)_HeavyChain 853 8495, 16137, 23779, 31421, 39063, 46705, 54347 ThioMab-hu10A8.v1-HC(A118C)_HeavyChain 854 8496, 16138, 23780, 31422, 39064, 46706, 54348 ThioMab-hu10A8.v1-HC(V205C)_HeavyChain 855 8497, 16139, 23781, 31423, 39065, 46707, 54349 ThioMab-hu10A8.v1-LC(A118C)_LightChain 856 8498, 16140, 23782, 31424, 39066, 46708, 54350 ThioMab-hu10AB.v1-LC(V205C)_LightChain 857 8499, 16141, 23783, 31425, 39067, 46709, 54351 ThioMAb-huMA79b.v17-HC(A118C)_HeavyChain 858 8500, 16142, 23784, 31426, 39068, 46710, 54352 ThioMAb-huMA79b.v17-HC(A118C)_LightChain 859 8501, 16143, 23785, 31427, 39069, 46711, 54353 ThioMAb-huMA79b.v18-HC(A118C)_HeavyChain 860 8502, 16144, 23786, 31428, 39070, 46712, 54354 ThioMAb-huMA79b.v28-HC(A118C)_LightChain 861 8503, 16145, 23787, 31429, 39071, 46713, 54355 ThioMAb-huMA79b.v28-LC(V205C)_LightChain 862 8504, 16146, 23788, 31430, 39072, 46714, 54356 Ticiliuab_HeavyChain1 863 8505, 16147, 23789, 31431, 39073, 46715, 54357 Ticilivab_LightChain1 864 8506, 16148, 23790, 31432, 39074, 46716, 54358 Tigatuzumab_HeavyChain1 865 8507, 16149, 23791, 31433, 39075, 46717, 54359 Tigatuzumab_HeavyChain 866 8508, 16150, 23792, 31434, 39076, 46718, 54360 Tigatuzumab_LightChain1 867 8509, 16151, 23793, 31435, 39077, 46719, 54361 Tigatuzumab_LightChain 868 8510, 16152, 23794, 31436, 39078, 46720, 54362 Tildrakizumab_HeavyChain1 869 8511, 16153, 23795, 31437, 39079, 46721, 54363 Tildrakizumab_LightChain1 870 8512, 16154, 23796, 31438, 39080, 46722, 54364 Tisotumab_vedotin_HeavyChain1 871 8513, 16155, 23797, 31439, 39081, 46723, 54365 Tisotumab_vedotin_LightChain1 872 8514, 16156, 23798, 31440, 39082, 46724, 54366 Tocilizumab_HeavyChain1 873 8515, 16157, 23799, 31441, 39083, 46725, 54367 Tocilizumab_LightChain1 874 8516, 16158, 23800, 31442, 39084, 46726, 54368 Tosatoxumab_HeavyChain1 875 8517, 16159, 23801, 31443, 39085, 46727, 54369 Tosatoxumab_LightChain1 876 8518, 16160, 23802, 31444, 39086, 46728, 54370 Tositumomab_HeavyChain 877 8519, 16161, 23803, 31445, 39087, 46729, 54371 Tositumomab_LightChain 878 8520, 16162, 23804, 31446, 39088, 46730, 54372 Tovetumab_HeavyChain1 879 8521, 16163, 23805, 31447, 39089, 46731, 54373 Tovetumab_LightChain1 880 8522, 16164, 23806, 31448, 39090, 46732, 54374 Tralokinumab_HeavyChain1 881 8523, 16165, 23807, 31449, 39091, 46733, 54375 Tralokinumab_LightChain1 882 8524, 16166, 23808, 31450, 39092, 46734, 54376 Trastuzuab_HeavyChain1 883 8525, 16167, 23809, 31451, 39093, 46735, 54377 Trastuzuab_LightChain1 884 8526, 16168, 23810, 31452, 39094, 46736, 54378 Trastuzumab_emtansine_HeavyChain1 885 8527, 16169, 23811, 31453, 39095, 46737, 54379 Trastuzumab_emtansine_LightChain1 886 8528, 16170, 23812, 31454, 39096, 46738, 54380 Trastuzumab_HeavyChain1 887 8529, 16171, 23813, 31455, 39097, 46739, 54381 Trastuzumab_HeavyChain 888 8530, 16172, 23814, 31456, 39098, 46740, 54382 Trastuzumab_HeavyChain_variant_1n8z_B 889 8531, 16173, 23815, 31457, 39099, 46741, 54383 Trastuzumab_HeavyChain_variant_7637_H 890 8532, 16174, 23816, 31458, 39100, 46742, 54384 Trastuzumab_LightChain1 891 8533, 16175, 23817, 31459, 39101, 46743, 54385 Trastuzumab_LightChain_variant_1n8z_A 892 8534, 16176, 23818, 31460, 39102, 46744, 54386 Trastuzumab_LightChain_variant_7637_L 893 8535, 16177, 23819, 31461, 39103, 46745, 54387 TRC-105_HeavyChain1 894 8536, 16178, 23820, 31462, 39104, 46746, 54388 TRC-105_LightChain1 895 8537, 16179, 23821, 31463, 39105, 46747, 54389 Tregalizumab_HeavyChain1 896 8538, 16180, 23822, 31464, 39106, 46748, 54390 Tregalizumab_LightChain1 897 8539, 16181, 23823, 31465, 39107, 46749, 54391 Tremelimumab_HeavyChain1 898 8540, 16182, 23824, 31466, 39108, 46750, 54392 Tremelimumab_LightChain1 899 8541, 16183, 23825, 31467, 39109, 46751, 54393 Trevogrumab_HeavyChain1 900 8542, 16184, 23826, 31468, 39110, 46752, 54394 Trevogrumab_LightChain1 901 8543, 16185, 23827, 31469, 39111, 46753, 54395 Tucotuzumab_celmoleukin_HeavyChain1 902 8544, 16186, 23828, 31470, 39112, 46754, 54396 Tucotuzumab_celmoleukin_LightChain1 903 8545, 16187, 23829, 31471, 39113, 46755, 54397 Ublituximab_HeavyChain1 904 8546, 16188, 23830, 31472, 39114, 46756, 54398 Ublituximab_LightChain1 905 8547, 16189, 23831, 31473, 39115, 46757, 54399 Ulocuplumab_HeavyChain1 906 8548, 16190, 23832, 31474, 39116, 46758, 54400 Ulocuplumab_LightChain1 907 8549, 16191, 23833, 31475, 39117, 46759, 54401 Urelumab_HeavyChain1 908 8550, 16192, 23834, 31476, 39118, 46760, 54402 Urelumab_LightChain1 909 8551, 16193, 23835, 31477, 39119, 46761, 54403 Urtoxazumab_HeavyChain1 910 8552, 16194, 23836, 31478, 39120, 46762, 54404 Urtoxazumab_LightChain1 911 8553, 16195, 23837, 31479, 39121, 46763, 54405 Ustekinumab_HeavyChain1 912 8554, 16196, 23838, 31480, 39122, 46764, 54406 Ustekinumab_LightChain1 913 8555, 16197, 23839, 31481, 39123, 46765, 54407 Vadastuximab_talirine_HeavyChain1 914 8556, 16198, 23840, 31482, 39124, 46766, 54408 Vadastuximab_talirine_LightChain1 915 8557, 16199, 23841, 31483, 39125, 46767, 54409 Vandortuzumab_vedotin_HeavyChain1 916 8558, 16200, 23842, 31484, 39126, 46768, 54410 Vandortuzumab_vedotin_LightChain1 917 8559, 16201, 23843, 31485, 39127, 46769, 54411 Vantictumab_HeavyChain1 918 8560, 16202, 23844, 31486, 39128, 46770, 54412 Vantictumab_LightChain1 919 8561, 16203, 23845, 31487, 39129, 46771, 54413 Vanucizumab_HeavyChain1 920 8562, 16204, 23846, 31488, 39130, 46772, 54414 Vanucizumab_HeavyChain2 921 8563, 16205, 23847, 31489, 39131, 46773, 54415 Vanucizumab_LightChain1 922 8564, 16206, 23848, 31490, 39132, 46774, 54416 Vanucizumab_LightChain2 923 8565, 16207, 23849, 31491, 39133, 46775, 54417 Varlilumab_HeavyChain1 924 8566, 16208, 23850, 31492, 39134, 46776, 54418 Varlilumab_LightChain1 925 8567, 16209, 23851, 31493, 39135, 46777, 54419 Vatelizumab_HeavyChain1 926 8568, 16210, 23852, 31494, 39136, 46778, 54420 Vatelizumab_LightChain1 927 8569, 16211, 23853, 31495, 39137, 46779, 54421 Vedolizumab_HeavyChain1 928 8570, 16212, 23854, 31496, 39138, 46780, 54422 Vedolizumab_LightChain1 929 8571, 16213, 23855, 31497, 39139, 46781, 54423 Veltuzumab_HeavyChain1 930 8572, 16214, 23856, 31498, 39140, 46782, 54424 Veltuzumab_LightChain1 931 8573, 16215, 23857, 31499, 39141, 46783, 54425 Vesencumab_HeavyChain1 932 8574, 16216, 23858, 31500, 39142, 46784, 54426 Vesencumab_LightChain1 933 8575, 16217, 23859, 31501, 39143, 46785, 54427 Visilizumab_HeavyChain1 934 8576, 16218, 23860, 31502, 39144, 46786, 54428 Visilizumab_LightChain1 935 8577, 16219, 23861, 31503, 39145, 46787, 54429 Volociximab_HeavyChain 936 8578, 16220, 23862, 31504, 39146, 46788, 54430 Volociximab_LightChain 937 8579, 16221, 23863, 31505, 39147, 46789, 54431 Vorsetuzumab_HeavyChain1 938 8580, 16222, 23864, 31506, 39148, 46790, 54432 Vorsetuzumab_LightChain1 939 8581, 16223, 23865, 31507, 39149, 46791, 54433 Vorsetuzumab_mafodotin_HeavyChain1 940 8582, 16224, 23866, 31508, 39150, 46792, 54434 Vorsetuzumab_mafodotin_LightChain1 941 8583, 16225, 23867, 31509, 39151, 46793, 54435 Yttrium_(90Y)_clivatuzumab_tetraxetan_HeavyChain1 942 8584, 16226, 23868, 31510, 39152, 46794, 54436 Yttrium_(90Y)_clivatuzumab_tetraxetan_LightChain1 943 8585, 16227, 23869, 31511, 39153, 46795, 54437 Yttrium_Y_90_epratuzumab_tetraxetan_HeavyChain1 944 8586, 16228, 23870, 31512, 39154, 46796, 54438 Yttrium_Y_90_epratuzumab_tetraxetan_LightChain1 945 8587, 16229, 23871, 31513, 39155, 46797, 54439 Yttrium_Y_90_epratuzumab_HeavyChain1 946 8588, 16230, 23872, 31514, 39156, 46798, 54440 Yttrium_Y_90_epratuzumab_LightChain1 947 8589, 16231, 23873, 31515, 39157, 46799, 54441 Zalutumumab_HeavyChain1 948 8590, 16232, 23874, 31516, 39158, 46800, 54442 Zalutumumab_LightChain1 949 8591, 16233, 23875, 31517, 39159, 46801, 54443 Zanolimumab_H0_HeavyChain 950 8592, 16234, 23876, 31518, 39160, 46802, 54444 Zanolimumab_L0_LightChain 951 8593, 16235, 23877, 31519, 39161, 46803, 54445 Zatuximab_HeavyChain1 952 8594, 16236, 23878, 31520, 39162, 46804, 54446 Zatuximab_LightChain1 953 8595, 16237, 23879, 31521, 39163, 46805, 54447 Actoxumab_HeavyChain 954 8596, 16238, 23880, 31522, 39164, 49806, 54448 Actoxumab_LightChain 955 8597, 16239, 23881, 31523, 39165, 49807, 54449 Andecaliximab_HeavyChain 956 8598, 16240, 23882, 31524, 39166, 49808, 54450 Andecaliximab_LightChain 957 8599, 16241, 23883, 31525, 39167, 49809, 54451 Aprutumab_HeavyChain 958 8600, 16242, 23884, 31526, 39168, 49810, 54452 Aprutumab_LightChain 959 8601, 16243, 23885, 31527, 39169, 49811, 54453 Azintuxizumab_HeavyChain 960 8602, 16244, 23886, 31528, 39170, 49812, 54454 Azintuxizumab_LightChain 961 8603, 16245, 23887, 31529, 39171, 49813, 54455 Blinatumomab_HeavyChain1 962 8604, 16246, 23888, 31530, 39172, 49814, 54456 Blinatumomab_HeavyChain2 963 8605, 16247, 23889, 31531, 39173, 49815, 54457 Blinatumomab_LightChain_HeavyChain_HeavyChain_Light 964 8606, 16248, 23890, 31532, 39174, 49816, 54458 Chain Blinatumomab_LightChain1 965 8607, 16249, 23891, 31533, 39175, 49817, 54459 Blinatumomab_LightChain2 966 8608, 16250, 23892, 31534, 39176, 49818, 54460 Brazikumab_HeavyChain 967 8609, 16251, 23893, 31535, 39177, 49819, 54461 Brazikumab_LightChain 968 8610, 16252, 23894, 31536, 39178, 49820, 54462 Brolucizumab_HeavyChain 969 8611, 16253, 23895, 31537, 39179, 49821, 54463 Brolucizumab_LightChain 970 8612, 16254, 23896, 31538, 39180, 49822, 54464 Cabiralizumab_HeavyChain 971 8613, 16255, 23897, 31539, 39181, 49823, 54465 Cabiralizumab_LightChain 972 8614, 16256, 23898, 31540, 39182, 49824, 54466 Camrelizumab_HeavyChain 973 8615, 16257, 23899, 31541, 39183, 49825, 54467 Camrelizumab_LightChain 974 8616, 16258, 23900, 31542, 39184, 49826, 54468 Caplanizumab_HeavyChain 975 8617, 16259, 23901, 31543, 39185, 49827, 54469 Citatuzumab_bogatox_HeavyChain 976 8618, 16260, 23902, 31544, 39186, 49828, 54470 Cosfroviximab_HeavyChain 977 8619, 16261, 23903, 31545, 39187, 49829, 54471 Cosfroviximab_LightChain 978 8620, 16262, 23904, 31546, 39188, 49830, 54472 Crizanlizumab_HeavyChain 979 8621, 16263, 23905, 31547, 39189, 49831, 54473 Crizanlizumab_LightChain 980 8622, 16264, 23906, 31548, 39190, 49832, 54474 Crotedumab_HeavyChain 981 8623, 16265, 23907, 31549, 39191, 49833, 54475 Crotedumab_LightChain 982 8624, 16266, 23908, 31550, 39192, 49834, 54476 Dezamizumab_HeavyChain 983 8625, 16267, 23909, 31551, 39193, 49835, 54477 Dezamizumab_LightChain 984 8626, 16268, 23910, 31552, 39194, 49836, 54478 Duvortuxizumab_Chain1_scFv 985 8627, 16269, 23911, 31553, 39195, 49837, 54479 Duvortuxizumab_Chain2_scfv 986 8628, 16270, 23912, 31554, 39196, 46838, 54480 Duvortuxizumab_Chain3_h-CH2—CH3 987 8629, 16271, 23913, 31555, 39197, 46839, 54481 Efungumab_HeavyChain 988 8630, 16272, 23914, 31556, 39198, 46840, 54482 Efungumab_HeavyChain_LightChain 989 8631, 16273, 23915, 31557, 39199, 46841, 54483 Efungumab_LightChain 990 8632, 16274, 23916, 31558, 39200, 46842, 54484 Elezanumab_HeavyChain 991 8633, 16275, 23917, 31559, 39201, 46843, 54485 Elezanumab_LightChain 992 8634, 16276, 23918, 31560, 39202, 46844, 54486 Emapalumab_HeavyChain 993 8635, 16277, 23919, 31561, 39203, 46845, 54487 Emapalumab_LightChain 994 8636, 16278, 23920, 31562, 39204, 46846, 54488 Enoblituzumab_HeavyChain 995 8637, 16279, 23921, 31563, 39205, 46847, 54489 Enoblituzumab_LightChain 996 8638, 16280, 23922, 31564, 39206, 46848, 54490 Eptinezumab_HeavyChain 997 8639, 16281, 23923, 31565, 39207, 46849, 54491 Eptinezumab_LightChain 998 8640, 16282, 23924, 31566, 39208, 46850, 54492 Erenumab_HeavyChain 999 8641, 16283, 23925, 31567, 39209, 46851, 54493 Erenumab_LightChain 1000 8642, 16284, 23926, 31568, 39210, 46852, 54494 Fremanezumab_HeavyChain 1001 8643, 16285, 23927, 31569, 39211, 46853, 54495 Fremanezumab_LightChain 1002 8644, 16286, 23928, 31570, 39212, 46854, 54496 Frunevetmab_HeavyChain 1003 8645, 16287, 23929, 31571, 39213, 46855, 54497 Frunevetmab_LightChain 1004 8646, 16288, 23930, 31572, 39214, 46856, 54498 Gatipotuzumab_HeavyChain 1005 8647, 16289, 23931, 31573, 39215, 46857, 54499 Gatipotuzumab_LightChain 1006 8648, 16290, 23932, 31574, 39216, 46858, 54500 Gedivumab_HeavyChain 1007 8649, 16291, 23933, 31575, 39217, 46859, 54501 Gedivumab_LightChain 1008 8650, 16292, 23934, 31576, 39218, 46860, 54502 Gemetuzumab_HeavyChain 1009 8651, 16293, 23935, 31577, 39219, 46861, 54503 Gemetuzumab_LightChain 1010 8652, 16294, 23936, 31578, 39220, 46862, 54504 Gilvetmab_HeavyChain 1011 8653, 16295, 23937, 31579, 39221, 46863, 54505 Gilvetmab_LightChain 1012 8654, 16296, 23938, 31580, 39222, 46864, 54506 Ifabotuzumab_HeavyChain 1013 8655, 16297, 23939, 31581, 39223, 46865, 54507 Ifabotuzumab_LightChain 1014 8656, 16298, 23940, 31582, 39224, 46866, 54508 Iratumumab_HeavyChain 1015 8657, 16299, 23941, 31583, 39225, 46867, 54509 Iratumumab_LightChain 1016 8658, 16300, 23942, 31584, 39226, 46868, 54510 Lacnotuzumab_HeavyChain 1017 8659, 16301, 23943, 31585, 39227, 46869, 54511 Lacnotuzumab_LightChain 1018 8660, 16302, 23944, 31586, 39228, 46870, 54512 Larcaviximab_HeavyChain 1019 8661, 16303, 23945, 31587, 39229, 46871, 54513 Larcaviximab_LightChain 1020 8662, 16304, 23946, 31588, 39230, 46872, 54514 Landalizumab_HeavyChain 1021 8663, 16305, 23947, 31589, 39231, 46873, 54515 Landalizumab_LightChain 1022 8664, 16306, 23948, 31590, 39232, 46874, 54516 Lesofavumab_HeavyChain 1023 8665, 16307, 23949, 31591, 39233, 46875, 54517 Lesofavumab_LightChain 1024 8666, 16308, 23950, 31592, 39234, 46875, 54518 Letolizumab_HeavyChain 1025 8667, 16309, 23951, 31593, 39235, 46877, 54519 Losatuxizumab_HeavyChain 1026 8668, 16310, 23952, 31594, 39236, 46878, 54520 Losatuxizumab_LightChain 1027 8669, 16311, 23953, 31595, 39237, 46879, 54521 Lupartumab_HeavyChain 1028 8670, 16312, 23954, 31596, 39238, 46880, 54522 Lupartumab_LightChain 1029 8671, 16313, 23955, 31597, 39239, 46881, 54523 Lutikizumab_HeavyChain 1030 8672, 16314, 23956, 31598, 39240, 46882, 54524 Lutikizumab_LightChain 1031 8673, 16315, 23957, 31599, 39241, 46883, 54525 Oleclumab_HeavyChain 1032 8674, 16316, 23958, 31600, 39242, 46884, 54526 Oleclumab_LightChain 1033 8675, 16317, 23959, 31601, 39243, 46885, 54527 Otlertuzumab_HeavyChain 1034 8676, 16318, 23960, 31602, 39244, 46886, 54528 Ozoralizumab_HeavyChain 1035 8677, 16319, 23961, 31603, 39245, 46887, 54529 Ozoralizumab_HeavyChain_HeavyChain_HeavyChain 1036 8678, 16320, 23962, 31604, 39246, 46888, 54530 Pasotuxizumab_HeavyChain_LightChain_HeavyChain_Light 1037 8679, 16321, 23963, 31605, 39247, 46889, 54531 Chain Pasotuxizumab_HeavyChain1 1038 8680, 16322, 23964, 31606, 39248, 46890, 54532 Pasotuxizumab_HeavyChain2 1039 8681, 16323, 23965, 31607, 39249, 46891, 54533 Pasotuxizumab_LightChain1 1040 8682, 16324, 23966, 31608, 39250, 46892, 54534 Pasotuxizumab_LightChain2 1041 8683, 16325, 23967, 31609, 39251, 46893, 54535 Placulumab_HeavyChain 1042 8684, 16326, 23968, 31610, 39252, 46894, 54536 Porgaviximab_HeavyChain 1043 8685, 16327, 23969, 31611, 39253, 46895, 54537 Porgaviximab_LightChain 1044 8686, 16328, 23970, 31612, 39254, 46896, 54538 Prezalumab_HeavyChain 1045 8687, 16329, 23971, 31613, 39255, 46897, 54539 Prezalumab_LightChain 1046 8688, 16330, 23972, 31614, 39256, 46898, 54540 Radretumab_HeavyChain 1047 8689, 16331, 23973, 31615, 39257, 46899, 54541 Radretumab_HeavyChain_LightChain 1048 8690, 16332, 23974, 31616, 39258, 46900, 54542 Radretumab_LightChain 1049 8691, 16333, 23975, 31617, 39259, 46901, 54543 Ranevetmab_HeavyChain1 1050 8692, 16334, 23976, 31618, 39260, 46902, 54544 Ranevetmab_HeavyChain2 1051 8693, 16335, 23977, 31619, 39261, 46903, 54545 Ranevetmab_LightChain 1052 8694, 16336, 23978, 31620, 39262, 46904, 54546 Remtolumab_HeavyChain 1053 8695, 16337, 23979, 31621, 39263, 46905, 54547 Remtolumab_LightChain 1054 8696, 16338, 23980, 31622, 39264, 46906, 54548 Rosmantuzumab_HeavyChain 1055 8697, 16339, 23981, 31623, 39265, 46907, 54549 Rosmantuzumab_LightChain 1056 8698, 16340, 23982, 31624, 39266, 46908, 54550 Rozanolixizumab_HeavyChain 1057 8699, 16341, 23983, 31625, 39267, 46909, 54551 Rozanolixizumab_LightChain 1058 8700, 16342, 23984, 31626, 39268, 46910, 54552 Sapalizumab_HeavyChain 1059 8701, 16343, 23985, 31627, 39269, 46911, 54553 Sapalizumab_LightChain 1060 8702, 16344, 23986, 31628, 39270, 46912, 54554 Salicrelumab_HeavyChain 1061 8703, 16345, 23987, 31629, 39271, 46913, 54555 Salicrelumab_LightChain 1062 8704, 16346, 23988, 31630, 39272, 46914, 54556 Solitomab_HeavyChain1 1063 8705, 16347, 23989, 31631, 39273, 46915, 54557 Solitomab_HeavyChain2 1064 8706, 16348, 23990, 31632, 39274, 46916, 54558 Solitomab_LightChain_HeavyChain_HeavyChain_LightChain 1065 8707, 16349, 23991, 31633, 39275, 46917, 54559 Solitomab_LightChain1 1066 8708, 16350, 23992, 31634, 39276, 46918, 54560 Solitomab_LightChain2 1067 8709, 16351, 23993, 31635, 39277, 46919, 54561 Suptavumab_HeavyChain2 1068 8710, 16352, 23994, 31636, 39278, 46920, 54562 Suvratoxumab_HeavyChain 1069 8711, 16353, 23995, 31637, 39279, 46921, 54563 Suvratoxumab_LightChain 1070 8712, 16354, 23996, 31638, 39280, 46922, 54564 Tadocizumab_LightChain 1071 8713, 16355, 23997, 31639, 39281, 46923, 54565 Tanezumab_HeavyChain 1072 8714, 16356, 23998, 31640, 39282, 46924, 54566 Tanezumab_LightChain 1073 8715, 16357, 23999, 31641, 39283, 46925, 54567 Tavolixizumab_HeavyChain 1074 8716, 16358, 24000, 31642, 39284, 46926, 54568 Tavolixizumab_LightChain 1075 8717, 16359, 24001, 31643, 39285, 46927, 54569 Telisotuzumab_HeavyChain 1076 8718, 16360, 24002, 31644, 39286, 46928, 54570 Telisotuzumab_LightChain 1077 8719, 16361, 24003, 31645, 39287, 46929, 54571 Telisotuzumab_vadotin_HeavyChain 1078 8720, 16362, 24004, 31646, 39288, 46930, 54572 Telisotuzumab_vadotin_LightChain 1079 8721, 16363, 24005, 31647, 39289, 46931, 54573 Timigutuzumab_HeavyChain 1080 8722, 16364, 24006, 31648, 39290, 46932, 54574 Timigutuzumab_LightChain 1081 8723, 16365, 24007, 31649, 39291, 46933, 54575 Timolumab_HeavyChain 1082 8724, 16366, 24008, 31650, 39292, 46934, 54576 Timolumab_LightChain 1083 8725, 16367, 24009, 31651, 39293, 46935, 54577 Tomuzotuximab_HeavyChain 1084 8726, 16368, 24010, 31652, 39294, 46936, 54578 Tomuzotuximab_LightChain 1085 8727, 16369, 24011, 31653, 39295, 46937, 54579 Trastuzumab_duocarmazine_HeavyChain 1086 8728, 16370, 24012, 31654, 39296, 46938, 54580 Trastuzumab_duocarmazine_LightChain 1087 8729, 16371, 24013, 31655, 39297, 46939, 54581 Varisacumab_HeavyChain 1088 8730, 16372, 24014, 31656, 39298, 46940, 54582 Varisacumab_LightChain 1089 8731, 16373, 24015, 31657, 39299, 46941, 54583 Vunakizumab_HeavyChain 1090 8732, 16374, 24016, 31658, 39300, 46942, 54584 Vunakizumab_LightChain 1091 8733, 16375, 24017, 31659, 39301, 46943, 54585 Xentuzumab_HeavyChain 1092 8734, 16376, 24018, 31660, 39302, 46944, 54586 Xentuzumab_LightChain 1093 8735, 16377, 24019, 31661, 39303, 46945, 54587 anti-rabies_S057_LightChain 1094 8736, 16378, 24020, 31662, 39304, 46946, 54588 anti-rabies_S057_HeavyChain 1095 8737, 16379, 24021, 31663, 39305, 46947, 54589 anti-rabies_S0JB_LightChain 1096 8738, 16380, 24022, 31664, 39306, 46948, 54590 anti-rabies_S0JB_HeavyChain 1097 8739, 16381, 24023, 31665, 39307, 46949, 54591 anti-rabies_S0JA_LightChain 1098 8740, 16382, 24024, 31666, 39308, 46950, 54592 anti-rabies_S0JA_HeavyChain 1099 8741, 16383, 24025, 31667, 39309, 46951, 54593 anti-rabies_LightChain 1100 8742, 16384, 24026, 31668, 39310, 46952, 54594 anti-rabies_HeavyChain 1101 8743, 16385, 24027, 31669, 39311, 46953, 54595 anti-rabies_LightChain 1102 8744, 16386, 24028, 31670, 39312, 46954, 54596 anti-rabies_HeavyChain 1103 8745, 16387, 24029, 31671, 39313, 46955, 54597 anti-RSV_5ITB_LightChain 1104 8746, 16388, 24030, 31672, 39314, 46956, 54598 anti-RSV_5ITB_HeavyChain 1105 8747, 16389, 24031, 31673, 39315, 46957, 54599 anti-alpha-toxin_4U6V_LightChain 1106 8748, 16390, 24032, 31674, 39316, 46958, 54600 anti-alpha-toxin_4U6V_HeavyChain 1107 8749, 16391, 24033, 31675, 39317, 46959, 54601 anti-alpha-toxin_4U6V_Chain-A 1108 8750, 16392, 24034, 31676, 39318, 46960, 54602 anti-alpha-toxin_4U6V_Chain-B 1109 8751, 16393, 24035, 31677, 39319, 46961, 54603 anti-lsdB_5D1Q_Chain-A 1110 8752, 16394, 24036, 31678, 39320, 46962, 54604 anti-lsdB_5D1Q_Chain-B 1111 8753, 16395, 24037, 31679, 39321, 46963, 54605 anti-lsdB_5D1Q_Chain-C 1112 8754, 16396, 24038, 31680, 39322, 46964, 54606 anti-lsdB_5D1Q_Chain-D 1113 8755, 16397, 24039, 31681, 39323, 46965, 54607 anti-lsdB_5D1Q_Chain-E 1114 8756, 16398, 24040, 31682, 39324, 46966, 54608 anti-lsdB_5D1Q_Chain-A 1115 8757, 16399, 24041, 31683, 39325, 46967, 54609 anti-lsdB_5D1X_Chain-B 1116 8758, 16400, 24042, 31684, 39326, 46968, 54610 anti-lsdB_5D1X_Chain-C 1117 8759, 16401, 24043, 31685, 39327, 46969, 54611 anti-lsdB_5D1X_Chain-D 1118 8760, 16402, 24044, 31686, 39328, 46970, 54612 anti-lsdB_5D1X_Chain-E 1119 8761, 16403, 24045, 31687, 39329, 46971, 54613 anti-lsdB_5D1Z_Chain-B 1120 8762, 16404, 24046, 31688, 39330, 46972, 54614 anti-lsdB_5D1Z_Chain-C 1121 8763, 16405, 24047, 31689, 39331, 46973, 54615 anti-lsdB_5D1Z_Chain-D 1122 8764, 16406, 24048, 31690, 39332, 46974, 54616 anti-lsdB_5D1Z_Chain-F 1123 8765, 16407, 24049, 31691, 39333, 46975, 54617 anti-lsdB_5D1Z_Chain-G 1124 8766, 16408, 24050, 31692, 39334, 46976, 54618 anti-lsdB_5D1Z_HeavyChain 1125 8767, 16409, 24051, 31693, 39335, 46977, 54619 anti-lsdB_5D1Z_Chain-1 1126 8768, 16410, 24052, 31694, 39336, 46978, 54620 anti-HIV_b12_LightChain 1127 8769, 16411, 24053, 31695, 39337, 46979, 54621 anti-HIV_b12_HeavyChain 1128 8770, 16412, 24054, 31696, 39338, 46980, 54622 anti-HIV_2GI2_LightChain 1129 8771, 16413, 24055, 31697, 39339, 46981, 54623 anti-HIV_2GI2_HeavyChain 1130 8772, 16414, 24056, 31698, 39340, 46982, 54624 anti-HIV_4E10_LightChain 1131 8773, 16415, 24057, 31699, 39341, 46983, 54625 anti-HIV_4E10_HeavyChain 1132 8774, 16416, 24058, 31700, 39342, 46984, 54626 anti-HIV_VRC01_LightChain 1133 8775, 16417, 24059, 31701, 39343, 46985, 54627 anti-HIV_VRC01_HeavyChain 1134 8776, 16418, 24060, 31702, 39344, 46986, 54628 anti-HIV_PG9_LightChain 1135 8777, 16419, 24061, 31703, 39345, 46987, 54629 anti-HIV_PG9_HeavyChain 1136 8778, 16420, 24062, 31704, 39346, 46988, 54630 anti-HIV_VRC07_LightChain 1137 8779, 16421, 24063, 31705, 39347, 46989, 54631 anti-HIV_VRC07_HeavyChain 1138 8780, 16422, 24064, 31706, 39348, 46990, 54632 anti-HIV_3BNC1I7_LightChain 1139 8781, 16423, 24065, 31707, 39349, 46991, 54633 anti-HIV_3BNC1I7_HeavyChain 1140 8782, 16424, 24066, 31708, 39350, 46992, 54634 anti-HIV_10-1074_LightChain 1141 8783, 16425, 24067, 31709, 39351, 46993, 54635 anti-HIV_10-1074_HeavyChain 1142 8784, 16426, 24068, 31710, 39352, 46994, 54636 anti-HIV_PGT12I_LightChain 1143 8785, 16427, 24069, 31711, 39353, 46995, 54637 anti-HIV_PGT12I_HeavyChain 1144 8786, 16428, 24070, 31712, 39354, 46996, 54638 anti-HIV_PGDM1400_LightChain 1145 8787, 16429, 24071, 31713, 39355, 46997, 54639 anti-HIV_PGDM1400_HeavyChain 1146 8788, 16430, 24072, 31714, 39356, 46998, 54640 anti-HIV_N6_LightChain 1147 8789, 16431, 24073, 31715, 39357, 46999, 54641 anti-HIV_N6_HeavyChain 1148 8790, 16432, 24074, 31716, 39358, 47000, 54642 anti-HIV_N6_GChain 1149 8791, 16433, 24075, 31717, 39359, 47001, 54643 anti-HIV_10E8_LightChain 1150 8792, 16434, 24076, 31718, 39360, 47002, 54644 anti-HIV_10E8_HeavyChain 1151 8793, 16435, 24077, 31719, 39361, 47003, 54645 anti-HIV_12A12_LightChain 1152 8794, 16436, 24078, 31720, 39362, 47004, 54646 anti-HIV_12A12_HeavyChain 1153 8795, 16437, 24079, 31721, 39363, 47005, 54647 anti-HIV_12A21_LightChain 1154 8796, 16438, 24080, 31722, 39364, 47006, 54648 anti-HIV_12A21_HeavyChain 1155 8797, 16439, 24081, 31723, 39365, 47007, 54649 anti-HIV_35022_LightChain 1156 8798, 16440, 24082, 31724, 39366, 47008, 54650 anti-HIV_35022_HeavyChain 1157 8799, 16441, 24083, 31725, 39367, 47009, 54651 anti-HIV_38C176_LightChain 1158 8800, 16442, 24084, 31726, 39368, 47010, 54652 anti-HIV_38C176_HeavyChain 1159 8801, 16443, 24085, 31727, 39369, 47011, 54653 anti-HIV_3BNC55_LightChain 1160 8802, 16444, 24086, 31728, 39370, 47012, 54654 anti-HIV_3BNC55_HeavyChain 1161 8803, 16445, 24087, 31729, 39371, 47013, 54655 anti-HIV_3BNC60_LightChain 1162 8804, 16446, 24088, 31730, 39372, 47014, 54656 anti-HIV_3BNC60_HeavyChain 1163 8805, 16447, 24089, 31731, 39373, 47015, 54657 anti-HIV_3BNC60_HeavyChain 1164 8806, 16448, 24090, 31732, 39374, 47016, 54658 anti-HIV_447-520_LightChain 1165 8807, 16449, 24091, 31733, 39375, 47017, 54659 anti-HIV_447-520_HeavyChain 1166 8808, 16450, 24092, 31734, 39376, 47018, 54660 anti-HIV_447-520_LightChain 1167 8809, 16451, 24093, 31735, 39377, 47019, 54661 anti-HIV_447-520_HeavyChain 1168 8810, 16452, 24094, 31736, 39378, 47020, 54662 anti-HIV_5H/I1-BMV-D5_LightChain 1169 8811, 16453, 24095, 31737, 39379, 47021, 54663 anti-HIV_5H/I1-BMV-D5_HeavyChain 1170 8812, 16454, 24096, 31738, 39380, 47022, 54664 anti-HIV_5H/I1-BMV-D5_A-Chain 1171 8813, 16455, 24097, 31739, 39381, 47023, 54665 anti-HIV_8ANC195_LightChain 1172 8814, 16456, 24098, 31740, 39382, 47024, 54666 anti-HIV_8ANC195_HeavyChain 1173 8815, 16457, 24099, 31741, 39383, 47025, 54667 anti-HIV_CAP256-VRC26.01_LightChain 1174 8816, 16458, 24100, 31742, 39384, 47026, 54668 anti-HIV_CAP256-VRC26.01_HeavyChain 1175 8817, 16459, 24101, 31743, 39385, 47027, 54669 anti-HIV_CAP256-VRC26.02_LightChain 1176 8818, 16460, 24102, 31744, 39386, 47028, 54670 anti-HIV_CAP256-VRC26.02_HeavyChain 1177 8819, 16461, 24103, 31745, 39387, 47029, 54671 anti-HIV_CAP256-VRC26.03_LightChain 1178 8820, 16462, 24104, 31746, 39388, 47030, 54672 anti-HIV_CAP256-VRC26.03_HeavyChain 1179 8821, 16463, 24105, 31747, 39389, 47031, 54673 anti-HIV_CAP256-VRC26.04_LightChain 1180 8822, 16464, 24106, 31748, 39390, 47032, 54674 anti-HIV_CAP256-VRC26.04_HeavyChain 1181 8823, 16465, 24107, 31749, 39391, 47033, 54675 anti-HIV_CAP256-VRC26.05_LightChain 1182 8824, 16466, 24108, 31750, 39392, 47034, 54676 anti-HIV_CAP256-VRC26.05_HeavyChain 1183 8825, 16467, 24109, 31751, 39393, 47035, 54677 anti-HIV_CAP256-VRC26.06_LightChain 1184 8826, 16468, 24110, 31752, 39394, 47036, 54678 anti-HIV_CAP256-VRC26.06_HeavyChain 1185 8827, 16469, 24111, 31753, 39395, 47037, 54679 anti-HIV_CAP256-VRC26.07_LightChain 1186 8828, 16470, 24112, 31754, 39396, 47038, 54680 anti-HIV_CAP256-VRC26.07_HeavyChain 1187 8829, 16471, 24113, 31755, 39397, 47039, 54681 anti-HIV_CAP256-VRC26.08_LightChain 1188 8830, 16472, 24114, 31756, 39398, 47040, 54682 anti-HIV_CAP256-VRC26.08_HeavyChain 1189 8831, 16473, 24115, 31757, 39399, 47041, 54683 anti-HIV_CAP256-VRC26.09_LightChain 1190 8832, 16474, 24116, 31758, 39400, 47042, 54684 anti-HIV_CAP256-VRC26.09_HeavyChain 1191 8833, 16475, 24117, 31759, 39401, 47043, 54685 anti-HIV_CAP256-VRC26.10_LightChain 1192 8834, 16476, 24118, 31760, 39402, 47044, 54686 anti-HIV_CAP256-VRC26.10_HeavyChain 1193 8835, 16477, 24119, 31761, 39403, 47045, 54687 anti-HIV_CAP256-VRC26.11_LightChain 1194 8836, 16478, 24120, 31762, 39404, 47046, 54688 anti-HIV_CAP256-VRC26.11_HeavyChain 1195 8837, 16479, 24121, 31763, 39405, 47047, 54689 anti-HIV_CAP256-VRC26.12_LightChain 1196 8838, 16480, 24122, 31764, 39406, 47048, 54690 anti-HIV_CAP256-VRC26.12_HeavyChain 1197 8839, 16481, 24123, 31765, 39407, 47049, 54691 anti-HIV_CAP256-VRC26.11_LightChain 1198 8840, 16482, 24124, 31766, 39408, 47050, 54692 anti-HIV_CAP256-VRC26.11_HeavyChain 1199 8841, 16483, 24125, 31767, 39409, 47051, 54693 anti-HIV_CAP256-VRC26.12_LightChain 1200 8842, 16484, 24126, 31768, 39410, 47052, 54694 anti-HIV_CAP256-VRC26.12_HeavyChain 1201 8843, 16485, 24127, 31769, 39411, 47053, 54695 anti-HIV_CAP256-VRC26.UCA_LightChain 1202 8844, 16486, 24128, 31770, 39412, 47054, 54696 anti-HIV_CAP256-VRC26.UCA_HeavyChain 1203 8845, 16487, 24129, 31771, 39413, 47055, 54697 anti-HIV_CH01_LightChain 1204 8846, 16488, 24130, 31772, 39414, 47056, 54698 anti-HIV_CH01_HeavyChain 1205 8847, 16489, 24131, 31773, 39415, 47057, 54699 anti-HIV_CH02_LightChain 1206 8848, 16490, 24132, 31774, 39416, 47058, 54700 anti-HIV_CH02_HeavyChain 1207 8849, 16491, 24133, 31775, 39417, 47059, 54701 anti-HIV_CH03_LightChain 1208 8850, 16492, 24134, 31776, 39418, 47060, 54702 anti-HIV_CH03_HeavyChain 1209 8851, 16493, 24135, 31777, 39419, 47061, 54703 anti-HIV_CH04_LightChain 1210 8852, 16494, 24136, 31778, 39420, 47062, 54704 anti-HIV_CH04_HeavyChain 1211 8853, 16495, 24137, 31779, 39421, 47063, 54705 anti-HIV_CH103_LightChain 1212 8854, 16496, 24138, 31780, 39422, 47064, 54706 anti-HIV_CH103_HeavyChain 1213 8855, 16497, 24139, 31781, 39423, 47065, 54707 anti-HIV_M66.6_LightChain 1214 8856, 16498, 24140, 31782, 39424, 47066, 54708 anti-HIV_M66.6_HeavyChain 1215 8857, 16499, 24141, 31783, 39425, 47067, 54709 anti-HIV_NIH45-46_LightChain 1216 8858, 16500, 24142, 31784, 39426, 47068, 54710 anti-HIV_NIH45-46_HeavyChain 1217 8859, 16501, 24143, 31785, 39427, 47069, 54711 anti-HIV_PG16_LightChain 1218 8860, 16502, 24144, 31786, 39428, 47070, 54712 anti-HIV_PG16_HeavyChain 1219 8861, 16503, 24145, 31787, 39429, 47071, 54713 anti-HIV_PGT122_LightChain 1220 8862, 16504, 24146, 31788, 39430, 47072, 54714 anti-HIV_PGT122_HeavyChain 1221 8863, 16505, 24147, 31789, 39431, 47073, 54715 anti-HIV_PGT123_LightChain 1222 8864, 16506, 24148, 31790, 39432, 47074, 54716 anti-HIV_PGT123_HeavyChain 1223 8865, 16507, 24149, 31791, 39433, 47075, 54717 anti-HIV_PGT125_LightChain 1224 8866, 16508, 24150, 31792, 39434, 47076, 54718 anti-HIV_PGT125_HeavyChain 1225 8867, 16509, 24151, 31793, 39435, 47077, 54719 anti-HIV_PGT126_LightChain 1226 8868, 16510, 24152, 31794, 39436, 47078, 54720 anti-HIV_PGT126_HeavyChain 1227 8869, 16511, 24153, 31795, 39437, 47079, 54721 anti-HIV_PGT127_LightChain 1228 8870, 16512, 24154, 31796, 39438, 47080, 54722 anti-HIV_PGT127_HeavyChain 1229 8871, 16513, 24155, 31797, 39439, 47081, 54723 anti-HIV_PGT128_LightChain 1230 8872, 16514, 24156, 31798, 39440, 47082, 54724 anti-HIV_PGT128_HeavyChain 1231 8873, 16515, 24157, 31799, 39441, 47083, 54725 anti-HIV_PGT130_LightChain 1232 8874, 16516, 24158, 31800, 39442, 47084, 54726 anti-HIV_PGT130_HeavyChain 1233 8875, 16517, 24159, 31801, 39443, 47085, 54727 anti-HIV_PGT131_LightChain 1234 8876, 16518, 24160, 31802, 39444, 47086, 54728 anti-HIV_PGT131_HeavyChain 1235 8877, 16519, 24161, 31803, 39445, 47087, 54729 anti-HIV_PGT135_LightChain 1236 8878, 16520, 24162, 31804, 39446, 47088, 54730 anti-HIV_PGT135_HeavyChain 1237 8879, 16521, 24163, 31805, 39447, 47089, 54731 anti-HIV_PGT136_LightChain 1238 8880, 16522, 24164, 31806, 39448, 47090, 54732 anti-HIV_PGT136_HeavyChain 1239 8881, 16523, 24165, 31807, 39449, 47091, 54733 anti-HIV_PGT137_LightChain 1240 8882, 16524, 24166, 31808, 39450, 47092, 54734 anti-HIV_PGT137_HeavyChain 1241 8883, 16525, 24167, 31809, 39451, 47093, 54735 anti-HIV_PGT141_LightChain 1242 8884, 16526, 24168, 31810, 39452, 47094, 54736 anti-HIV_PGT141_HeavyChain 1243 8885, 16527, 24169, 31811, 39453, 47095, 54737 anti-HIV_PGT142_LightChain 1244 8886, 16528, 24170, 31812, 39454, 47096, 54738 anti-HIV_PGT142_HeavyChain 1245 8887, 16529, 24171, 31813, 39455, 47097, 54739 anti-HIV_PGT143_LightChain 1246 8888, 16530, 24172, 31814, 39456, 47098, 54740 anti-HIV_PGT143_HeavyChain 1247 8889, 16531, 24173, 31815, 39457, 47099, 54741 anti-HIV_PGT144_LightChain 1248 8890, 16532, 24174, 31816, 39458, 47100, 54742 anti-HIV_PGT144_HeavyChain 1249 8891, 16533, 24175, 31817, 39459, 47101, 54743 anti-HIV_PGT145_LightChain 1250 8892, 16534, 24176, 31818, 39460, 47102, 54744 anti-HIV_PGT145_HeavyChain 1251 8893, 16535, 24177, 31819, 39461, 47103, 54745 anti-HIV_PGT151_LightChain 1252 8894, 16536, 24178, 31820, 39462, 47104, 54746 anti-HIV_PGT151_HeavyChain 1253 8895, 16537, 24179, 31821, 39463, 47105, 54747 anti-HIV_PGT152_LightChain 1254 8896, 16538, 24180, 31822, 39464, 47106, 54748 anti-HIV_PGT152_HeavyChain 1255 8897, 16539, 24181, 31823, 39465, 47107, 54749 anti-HIV_VRC-CH30_LightChain 1256 8898, 16540, 24182, 31824, 39466, 47108, 54750 anti-HIV_VRC-CH30_HeavyChain 1257 8899, 16541, 24183, 31825, 39467, 47109, 54751 anti-HIV_VRC-CH31_LightChain 1258 8900, 16542, 24184, 31826, 39468, 47110, 54752 anti-HIV_VRC-CH31_HeavyChain 1259 8901, 16543, 24185, 31827, 39469, 47111, 54753 anti-HIV_VRC-CH32_LightChain 1250 8902, 16544, 24186, 31828, 39470, 47112, 54754 anti-HIV_VRC-CH32_HeavyChain 1251 8903, 16545, 24187, 31829, 39471, 47113, 54755 anti-HIV_VRC-CH33_LightChain 1252 8904, 16546, 24188, 31830, 39472, 47114, 54756 anti-HIV_VRC-CH33_HeavyChain 1253 8905, 16547, 24189, 31831, 39473, 47115, 54757 anti-HIV_VRC-CH34_LightChain 1254 8906, 16548, 24190, 31832, 39474, 47116, 54758 anti-HIV_VRC-CH34_HeavyChain 1255 8907, 16549, 24191, 31833, 39475, 47117, 54759 anti-HIV_VRC-PG04_LightChain 1256 8908, 16550, 24192, 31834, 39476, 47118, 54760 anti-HIV_VRC-PG04_HeavyChain 1257 8909, 16551, 24193, 31835, 39477, 47119, 54761 anti-HIV_VRC-PG04b_LightChain 1258 8910, 16552, 24194, 31836, 39478, 47120, 54762 anti-HIV_VRC-PG04b_HeavyChain 1259 8911, 16553, 24195, 31837, 39479, 47121, 54763 anti-HIV_VRC-PG20_LightChain 1270 8912, 16554, 24196, 31838, 39480, 47122, 54764 anti-HIV_VRC-PG20_HeavyChain 1271 8913, 16555, 24197, 31839, 39481, 47123, 54765 anti-HIV_VRC-PG20_G-Chain 1272 8914, 16556, 24198, 31840, 39482, 47124, 54766 anti-HIV_VRC02_LightChain 1273 8915, 16557, 24199, 31841, 39483, 47125, 54767 anti-HIV_VRC02_HeavyChain 1274 8916, 16558, 24200, 31842, 39484, 47126, 54768 anti-HIV_VRC03_LightChain 1275 8917, 16559, 24201, 31843, 39485, 47127, 54769 anti-HIV_VRC03_HeavyChain 1276 8918, 16560, 24202, 31844, 39486, 47128, 54770 anti-HIV_VRC23_LightChain 1277 8919, 16561, 24203, 31845, 39487, 47129, 54771 anti-HIV_VRC23_HeavyChain 1278 8920, 16562, 24204, 31846, 39488, 47130, 54772 anti-HIV_VRC23_G-Chain 1279 8921, 16563, 24205, 31847, 39489, 47131, 54773 anti-HIV_5CCK_LightChain 1280 8922, 16564, 24206, 31848, 39490, 47132, 54774 anti-HIV_5CCK_HeavyChain 1281 8923, 16565, 24207, 31849, 39491, 47133, 54775 anti-HIV_5AWN_LightChain 1282 8924, 16566, 24208, 31850, 39492, 47134, 54776 anti-HIV_5AWN_HeavyChain 1283 8925, 16567, 24209, 31851, 39493, 47135, 54777 anti-HIV_3QEG_LightChain 1284 8926, 16568, 24210, 31852, 39494, 47136, 54778 anti-HIV_3QEG_HeavyChain 1285 8927, 16569, 24211, 31853, 39495, 47137, 54779 anti-HIV_INOX_K-Chain 1286 8928, 16570, 24212, 31854, 39496, 47138, 54780 anti-HIV_INOX_M-Chain 1287 8929, 16571, 24213, 31855, 39497, 47139, 54781 anti-HIV_3QEH_HeavyChain 1288 8930, 16572, 24214, 31856, 39498, 47140, 54782 anti-HIV_3QEH_G-Chain 1289 8931, 16573, 24215, 31857, 39499, 47141, 54783 anti-HIV_2BIH_HeavyChain 1290 8932, 16574, 24216, 31858, 39500, 47142, 54784 anti-HIV_2BIH_LightChain 1291 8933, 16575, 24217, 31859, 39501, 47143, 54785 anti-HIV_3TNM_B-Chain 1292 8934, 16576, 24218, 31860, 39502, 47144, 54786 anti-HIV_3TNM_A-Chain 1293 8935, 16577, 24219, 31861, 39503, 47145, 54787 anti-HIV_3UJJ_HeavyChain 1294 8936, 16578, 24220, 31862, 39504, 47146, 54788 anti-HIV_3UJJ_LightChain 1295 8937, 16579, 24221, 31863, 39505, 47147, 54789 anti-HIV_3UJI_HeavyChain 1296 8938, 16580, 24222, 31864, 39506, 47148, 54790 anti-HIV_3UJI_LightChain 1297 8939, 16581, 24223, 31865, 39507, 47149, 54791 anti-HIV_2QSC_HeavyChain 1298 8940, 16582, 24224, 31866, 39508, 47150, 54792 anti-HIV_2QSC_LightChain 1299 8941, 16583, 24225, 31867, 39509, 47151, 54793 anti-HIV_3MLZ_HeavyChain 1300 8942, 16584, 24226, 31868, 39510, 47152, 54794 anti-HIV_3MLZ_LightChain 1301 8943, 16585, 24227, 31869, 39511, 47153, 54795 anti-HIV_3MLX_I-Chain 1302 8944, 16586, 24228, 31870, 39512, 47154, 54796 anti-HIV_3MLX_M-Chain 1303 8945, 16587, 24229, 31871, 39513, 47155, 54797 anti-HIV_3MLW_I-Chain 1304 8946, 16588, 24230, 31872, 39514, 47156, 54798 anti-HIV_3MLW_M-Chain 1305 8947, 16589, 24231, 31873, 39515, 47157, 54799 anti-HIV_3MLV_N-Chain 1306 8948, 16590, 24232, 31874, 39516, 47158, 54800 anti-HIV_3MLV_M-Chain 1307 8949, 16591, 24233, 31875, 39517, 47159, 54801 anti-HIV_3MLU_LightChain 1308 8950, 16592, 24234, 31876, 39518, 47160, 54802 anti-HIV_3MLT_G-Chain 1309 8951, 16593, 24235, 31877, 39519, 47161, 54803 anti-HIV_3G01_HeavyChain 1310 8952, 16594, 24236, 31878, 39520, 47162, 54804 anti-HIV_3G01_LightChain 1311 8953, 16595, 24237, 31879, 39521, 47163, 54805 anti-HIV_4XCY_J-Chain 1312 8954, 16596, 24238, 31880, 39522, 47164, 54806 anti-HIV_4XCY_K-Chain 1313 8955, 16597, 24239, 31881, 39523, 47165, 54807 anti-HIV_4YBL_C-Chain 1314 8956, 16598, 24240, 31882, 39524, 47166, 54808 anti-HIV_4YBL_B-Chain 1315 8957, 16599, 24241, 31883, 39525, 47167, 54809 anti-HIV_4R4N_X-Chain 1316 8958, 16600, 24242, 31884, 39526, 47168, 54810 anti-HIV_4R4B_F-Chain 1317 8959, 16601, 24243, 31885, 39527, 47169, 54811 anti-HIV_3JUY_D-Chain 1318 8960, 16602, 24244, 31886, 39528, 47170, 54812 anti-HIV_4KG5_HeavyChain 1319 8961, 16603, 24245, 31887, 39529, 47171, 54813 anti-HIV_4KG5_LightChain 1320 8962, 16604, 24246, 31888, 39530, 47172, 54814 anti-HIV-1_LightChain 1321 8963, 16605, 24247, 31889, 39531, 47173, 54815 anti-HIV-1_LightChain 1322 8964, 16606, 24248, 31890, 39532, 47174, 54816 anti-HIV-1_LightChain 1323 8965, 16607, 24249, 31891, 39533, 47175, 54817 anti-HIV-1_LightChain 1324 8966, 16608, 24250, 31892, 39534, 47176, 54818 anti-HIV-1_LightChain 1325 8967, 16609, 24251, 31893, 39535, 47177, 54819 anti-HIV-1_LightChain 1326 8968, 16610, 24252, 31894, 39536, 47178, 54820 anti-HIV-1_HeavyChain 1327 8969, 16611, 24253, 31895, 39537, 47179, 54821 anti-HIV-1_HeavyChain 1328 8970, 16612, 24254, 31896, 39538, 47180, 54822 anti-HIV-1_HeavyChain 1329 8971, 16613, 24255, 31897, 39539, 47181, 54823 anti-HIV-1_HeavyChain 1330 8972, 16614, 24256, 31898, 39540, 47182, 54824 anti-HIV-1_HeavyChain 1331 8973, 16615, 24257, 31899, 39541, 47183, 54825 anti-HIV-1_HeavyChain 1332 8974, 16616, 24258, 31900, 39542, 47184, 54826 anti-HIV-1_HeavyChain 1333 8975, 16617, 24259, 31901, 39543, 47185, 54827 anti-HIV-1_HeavyChain 1334 8976, 16618, 24260, 31902, 39544, 47186, 54828 anti-HIV-1_HeavyChain 1335 8977, 16619, 24261, 31903, 39545, 47187, 54829 anti-HIV-1_HeavyChain 1336 8978, 16620, 24262, 31904, 39546, 47188, 54830 anti-HIV-1_LightChain 1337 8979, 16621, 24263, 31905, 39547, 47189, 54831 anti-HIV-1_LightChain 1338 8980, 16622, 24264, 31906, 39548, 47190, 54832 anti-HIV-1_LightChain 1339 8981, 16623, 24265, 31907, 39549, 47191, 54833 anti-HIV-1_LightChain 1340 8982, 16624, 24266, 31908, 39550, 47192, 54834 anti-HIV-1_LightChain 1341 8983, 16625, 24267, 31909, 39551, 47193, 54835 anti-HIV-1_LightChain 1342 8984, 16626, 24268, 31910, 39552, 47194, 54836 anti-HIV-1_LightChain 1343 8985, 16627, 24269, 31911, 39553, 47195, 54837 anti-HIV-1_LightChain 1344 8986, 16628, 24270, 31912, 39554, 47196, 54838 anti-HIV-1_HeavyChain 1345 8987, 16629, 24271, 31913, 39555, 47197, 54839 anti-HIV-1_HeavyChain 1346 8988, 16630, 24272, 31914, 39556, 47198, 54840 anti-HIV-1_HeavyChain 1347 8989, 16631, 24273, 31915, 39557, 47199, 54841 anti-HIV-1_HeavyChain 1348 8990, 16632, 24274, 31916, 39558, 47200, 54842 anti-HIV-1_HeavyChain 1349 8991, 16633, 24275, 31917, 39559, 47201, 54843 anti-HIV-1_HeavyChain 1350 8992, 16634, 24276, 31918, 39560, 47202, 54844 anti-HIV-1_HeavyChain 1351 8993, 16635, 24277, 31919, 39561, 47203, 54845 anti-HIV-1_HeavyChain 1352 8994, 16636, 24278, 31920, 39562, 47204, 54846 anti-HIV_V3_HeavyChain 1353 8995, 16637, 24279, 31921, 39563, 47205, 54847 anti-HIV_V3_HeavyChain 1354 8996, 16638, 24280, 31922, 39564, 47206, 54848 anti-HIV_V3_HeavyChain 1355 8997, 16639, 24281, 31923, 39565, 47207, 54849 anti-HIV_V3_HeavyChain 1356 8998, 16640, 24282, 31924, 39566, 47208, 54850 anti-HIV_V3_HeavyChain 1357 8999, 16641, 24283, 31925, 39567, 47209, 54851 anti-HIV_V3_HeavyChain 1358 9000, 16642, 24284, 31926, 39568, 47210, 54852 anti-HIV_V3_HeavyChain 1359 9001, 16643, 24285, 31927, 39569, 47211, 54853 anti-HIV_V3_HeavyChain 1360 9002, 16644, 24286, 31928, 39570, 47212, 54854 anti-HIV_V3_HeavyChain 1361 9003, 16645, 24287, 31929, 39571, 47213, 54855 anti-HIV_V3_HeavyChain 1362 9004, 16646, 24288, 31930, 39572, 47214, 54856 anti-HIV_V3_HeavyChain 1363 9005, 16647, 24289, 31931, 39573, 47215, 54857 anti-HIV_V3_HeavyChain 1364 9006, 16648, 24290, 31932, 39574, 47216, 54858 anti-HIV_CD4bs_HeavyChain 1365 9007, 16649, 24291, 31933, 39575, 47217, 54859 anti-HIV_CD4bs_HeavyChain 1366 9008, 16650, 24292, 31934, 39576, 47218, 54860 anti-HIV_CD4bs_HeavyChain 1367 9009, 16651, 24293, 31935, 39577, 47219, 54861 anti-HIV_CD4bs_HeavyChain 1368 9010, 16652, 24294, 31936, 39578, 47220, 54862 anti-HIV_CD4bs_HeavyChain 1369 9011, 16653, 24295, 31937, 39579, 47221, 54863 anti-HIV_CD4bs_HeavyChain 1370 9012, 16654, 24296, 31938, 39580, 47222, 54864 anti-HIV_CD4bs_HeavyChain 1371 9013, 16655, 24297, 31939, 39581, 47223, 54865 anti-HIV_CD4bs_HeavyChain 1372 9014, 16656, 24298, 31940, 39582, 47224, 54866 anti-HIV_CD4bs_HeavyChain 1373 9015, 16657, 24299, 31941, 39583, 47225, 54867 anti-HIV_CD4bs_HeavyChain 1374 9016, 16658, 24300, 31942, 39584, 47226, 54868 anti-HIV_V2_HeavyChain 1375 9017, 16659, 24301, 31943, 39585, 47227, 54869 anti-HIV_V2_HeavyChain 1376 9018, 16660, 24302, 31944, 39586, 47228, 54870 anti-HIV_V2_HeavyChain 1377 9019, 16661, 24303, 31945, 39587, 47229, 54871 anti-HIV_V2_HeavyChain 1378 9020, 16662, 24304, 31946, 39588, 47230, 54872 anti-HIV_V2_HeavyChain 1379 9021, 16663, 24305, 31947, 39589, 47231, 54873 anti-HIV_V2_HeavyChain 1380 9022, 16664, 24306, 31948, 39590, 47232, 54874 anti-HIV_V3_LightChain 1381 9023, 16665, 24307, 31949, 39591, 47233, 54875 anti-HIV_V3_LightChain 1382 9024, 16666, 24308, 31950, 39592, 47234, 54876 anti-HIV_V3_LightChain 1383 9025, 16667, 24309, 31951, 39593, 47235, 54877 anti-HIV_V3_LightChain 1384 9026, 16668, 24310, 31952, 39594, 47236, 54878 anti-HIV_V3_LightChain 1385 9027, 16669, 24311, 31953, 39595, 47237, 54879 anti-HIV_V3_LightChain 1386 9028, 16670, 24312, 31954, 39596, 47238, 54880 anti-HIV_V3_LightChain 1387 9029, 16671, 24313, 31955, 39597, 47239, 54881 anti-HIV_V3_LightChain 1388 9030, 16672, 24314, 31956, 39598, 47240, 54882 anti-HIV_V3_LightChain 1389 9031, 16673, 24315, 31957, 39599, 47241, 54883 anti-HIV_V3_LightChain 1390 9032, 16674, 24316, 31958, 39600, 47242, 54884 anti-HIV_V3_LightChain 1391 9033, 16675, 24317, 31959, 39601, 47243, 54885 anti-HIV_V3_LightChain 1392 9034, 16676, 24318, 31960, 39602, 47244, 54886 anti-HIV_V3_LightChain 1393 9035, 16677, 24319, 31961, 39603, 47245, 54887 anti-HIV_V3_LightChain 1394 9036, 16678, 24320, 31962, 39604, 47246, 54888 anti-HIV_V3_LightChain 1395 9037, 16679, 24321, 31963, 39605, 47247, 54889 anti-HIV_V3_LightChain 1396 9038, 16680, 24322, 31964, 39606, 47248, 54890 anti-HIV_V3_LightChain 1397 9039, 16681, 24323, 31965, 39607, 47249, 54891 anti-HIV_V3_LightChain 1398 9040, 16682, 24324, 31966, 39608, 47250, 54892 anti-HIV_V3_LightChain 1399 9041, 16683, 24325, 31967, 39609, 47251, 54893 anti-HIV_V3_LightChain 1400 9042, 16684, 24326, 31968, 39610, 47252, 54894 anti-HIV_V3_LightChain 1401 9043, 16685, 24327, 31969, 39611, 47253, 54895 anti-HIV_V3_LightChain 1402 9044, 16686, 24328, 31970, 39612, 47254, 54896 anti-HIV_V3_LightChain 1403 9045, 16687, 24329, 31971, 39613, 47255, 54897 anti-HIV_V3_LightChain 1404 9046, 16688, 24330, 31972, 39614, 47256, 54898 anti-HIV_V3_LightChain 1405 9047, 16689, 24331, 31973, 39615, 47257, 54899 anti-HIV_V3_LightChain 1406 9048, 16690, 24332, 31974, 39616, 47258, 54900 anti-HIV_V3_LightChain 1407 9049, 16691, 24333, 31975, 39617, 47259, 54901 anti-HIV_V3_LightChain 1408 9050, 16692, 24334, 31976, 39618, 47260, 54902 anti-HIV_V3_LightChain 1409 9051, 16693, 24335, 31977, 39619, 47261, 54903 anti-HIV_V3_LightChain 1410 9052, 16694, 24336, 31978, 39620, 47262, 54904 anti-HIV_CD4bs_LightChain 1411 9053, 16695, 24337, 31979, 39621, 47263, 54905 anti-HIV_CD4bs_LightChain 1412 9054, 16696, 24338, 31980, 39622, 47264, 54906 anti-HIV_CD4bs_LightChain 1413 9055, 16697, 24339, 31981, 39623, 47265, 54907 anti-HIV_CD4bs_LightChain 1414 9056, 16698, 24340, 31982, 39624, 47266, 54908 anti-HIV_CD4bs_LightChain 1415 9057, 16699, 24341, 31983, 39625, 47267, 54909 anti-HIV_CD4bs_LightChain 1416 9058, 16700, 24342, 31984, 39626, 47268, 54910 anti-HIV_CD4bs_LightChain 1417 9059, 16701, 24343, 31985, 39627, 47269, 54911 anti-HIV_CD4bs_LightChain 1418 9060, 16702, 24344, 31986, 39628, 47270, 54912 anti-HIV_CD4bs_LightChain 1419 9061, 16703, 24345, 31987, 39629, 47271, 54913 anti-HIV_CD4bs_LightChain 1420 9062, 16704, 24346, 31988, 39630, 47272, 54914 anti-HIV_V2_LightChain 1421 9063, 16705, 24347, 31989, 39631, 47273, 54915 anti-HIV_V2_LightChain 1422 9064, 16706, 24348, 31990, 39632, 47274, 54916 anti-HIV_V2_LightChain 1423 9065, 16707, 24349, 31991, 39633, 47275, 54917 anti-HIV_V2_LightChain 1424 9066, 16708, 24350, 31992, 39634, 47276, 54918 anti-HIV_V2_LightChain 1425 9067, 16709, 24351, 31993, 39635, 47277, 54919 anti-HIV_V2_LightChain 1426 9068, 16710, 24352, 31994, 39636, 47278, 54920 anti-HIV_10E8 1427 9069, 16711, 24353, 31995, 39637, 47279, 54921 anti-HIV_10E8 1428 9070, 16712, 24354, 31996, 39638, 47280, 54922 anti-HIV_10E8 1429 9071, 16713, 24355, 31997, 39639, 47281, 54923 anti-HIV_10E8 1430 9072, 16714, 24356, 31998, 39640, 47282, 54924 anti-HIV_10E8 1431 9073, 16715, 24357, 31999, 39641, 47283, 54925 anti-HIV_10E8 1432 9074, 16716, 24358, 32000, 39642, 47284, 54926 anti-HIV_10E8 1433 9075, 16717, 24359, 32001, 39643, 47285, 54927 anti-HIV_10E8 1434 9076, 16718, 24360, 32002, 39644, 47286, 54928 anti-HIV_10E8 1435 9077, 16719, 24361, 32003, 39645, 47287, 54929 anti-HIV_10E8 1436 9078, 16720, 24362, 32004, 39646, 47288, 54930 anti-HIV_10E8 1437 9079, 16721, 24363, 32005, 39647, 47289, 54931 anti-HIV_10E8 1438 9080, 16722, 24364, 32006, 39648, 47290, 54932 anti-HIV_10E8 1439 9081, 16723, 24365, 32007, 39649, 47291, 54933 anti-HIV_10E8 1440 9082, 16724, 24366, 32008, 39650, 47292, 54934 anti-HIV_10E8 1441 9083, 16725, 24367, 32009, 39651, 47293, 54935 anti-HIV_10E8 1442 9084, 16726, 24368, 32010, 39652, 47294, 54936 anti-HIV_10E8 1443 9085, 16727, 24369, 32011, 39653, 47295, 54937 anti-HIV_10E8 1444 9086, 16728, 24370, 32012, 39654, 47296, 54938 anti-HIV_10E8 1445 9087, 16729, 24371, 32013, 39655, 47297, 54939 anti-HIV_10E8 1446 9088, 16730, 24372, 32014, 39656, 47298, 54940 anti-HIV_10E8 1447 9089, 16731, 24373, 32015, 39657, 47299, 54941 anti-HIV_10E8 1448 9090, 16732, 24374, 32016, 39658, 47300, 54942 anti-HIV_10E8 1449 9091, 16733, 24375, 32017, 39659, 47301, 54943 anti-HIV_10E8 1450 9092, 16734, 24376, 32018, 39660, 47302, 54944 anti-HIV_10E8 1451 9093, 16735, 24377, 32019, 39661, 47303, 54945 anti-HIV_10E8 1452 9094, 16736, 24378, 32020, 39662, 47304, 54946 anti-HIV_10E8 1453 9095, 16737, 24379, 32021, 39663, 47305, 54947 anti-HIV_10E8 1454 9096, 16738, 24380, 32022, 39664, 47306, 54948 anti-HIV_10E8 1455 9097, 16739, 24381, 32023, 39665, 47307, 54949 anti-HIV_10E8 1456 9098, 16740, 24382, 32024, 39666, 47308, 54950 anti-HIV_10E8 1457 9099, 16741, 24383, 32025, 39667, 47309, 54951 anti-HIV_10E8 1458 9100, 16742, 24384, 32026, 39668, 47310, 54952 anti-HIV-1_LightChain 1459 9101, 16743, 24385, 32027, 39669, 47311, 54953 anti-HIV-1_LightChain 1460 9102, 16744, 24386, 32028, 39670, 47312, 54954 anti-HIV-1_LightChain 1461 9103, 16745, 24387, 32029, 39671, 47313, 54955 anti-HIV-1_LightChain 1462 9104, 16746, 24388, 32030, 39672, 47314, 54956 anti-HIV-1_LightChain 1463 9105, 16747, 24389, 32031, 39673, 47315, 54957 anti-HIV-1_LightChain 1464 9106, 16748, 24390, 32032, 39674, 47316, 54958 anti-HIV-1_LightChain 1465 9107, 16749, 24391, 32033, 39675, 47317, 54959 anti-HIV-1_LightChain 1466 9108, 16750, 24392, 32034, 39676, 47318, 54960 anti-HIV-1_LightChain 1467 9109, 16751, 24393, 32035, 39677, 47319, 54961 anti-HIV-1_LightChain 1468 9110, 16752, 24394, 32036, 39678, 47320, 54962 anti-HIV-1_LightChain 1469 9111, 16753, 24395, 32037, 39679, 47321, 54963 anti-HIV-1_LightChain 1470 9112, 16754, 24396, 32038, 39680, 47322, 54964 anti-HIV-1_LightChain 1471 9113, 16755, 24397, 32039, 39681, 47323, 54965 anti-HIV-1_LightChain 1472 9114, 16756, 24398, 32040, 39682, 47324, 54966 anti-HIV-1_LightChain 1473 9115, 16757, 24399, 32041, 39683, 47325, 54967 anti-HIV-1_LightChain 1474 9116, 16758, 24400, 32042, 39684, 47326, 54968 anti-HIV-1_LightChain 1475 9117, 16759, 24401, 32043, 39685, 47327, 54969 anti-HIV-1_LightChain 1476 9118, 16760, 24402, 32044, 39686, 47328, 54970 anti-HIV-1_LightChain 1477 9119, 16761, 24403, 32045, 39687, 47329, 54971 anti-HIV-1_LightChain 1478 9120, 16762, 24404, 32046, 39688, 47330, 54972 anti-HIV-1_LightChain 1479 9121, 16763, 24405, 32047, 39689, 47331, 54973 anti-HIV-1_LightChain 1480 9122, 16764, 24406, 32048, 39690, 47332, 54974 anti-HIV-1_LightChain 1481 9123, 16765, 24407, 32049, 39691, 47333, 54975 anti-HIV-1_LightChain 1482 9124, 16766, 24408, 32050, 39692, 47334, 54976 anti-HIV-1_LightChain 1483 9125, 16767, 24409, 32051, 39693, 47335, 54977 anti-HIV-1_LightChain 1484 9126, 16768, 24410, 32052, 39694, 47336, 54978 anti-HIV-1_LightChain 1485 9127, 16769, 24411, 32053, 39695, 47337, 54979 anti-HIV-1_LightChain 1486 9128, 16770, 24412, 32054, 39696, 47338, 54980 anti-HIV-1_LightChain 1487 9129, 16771, 24413, 32055, 39697, 47339, 54981 anti-HIV-1_LightChain 1488 9130, 16772, 24414, 32056, 39698, 47340, 54982 anti-HIV-1_LightChain 1489 9131, 16773, 24415, 32057, 39699, 47341, 54983 anti-HIV-1_LightChain 1490 9132, 16774, 24416, 32058, 39700, 47342, 54984 anti-HIV-1_LightChain 1491 9133, 16775, 24417, 32059, 39701, 47343, 54985 anti-HIV-1_LightChain 1492 9134, 16776, 24418, 32060, 39702, 47344, 54986 anti-HIV-1_LightChain 1493 9135, 16777, 24419, 32061, 39703, 47345, 54987 anti-HIV-1_LightChain 1494 9136, 16778, 24420, 32062, 39704, 47346, 54988 anti-HIV-1_LightChain 1495 9137, 16779, 24421, 32063, 39705, 47347, 54989 anti-HIV-1_LightChain 1496 9138, 16780, 24422, 32064, 39706, 47348, 54990 anti-HIV-1_LightChain 1497 9139, 16781, 24423, 32065, 39707, 47349, 54991 anti-HIV-1_LightChain 1498 9140, 16782, 24424, 32066, 39708, 47350, 54992 anti-HIV-1_LightChain 1499 9141, 16783, 24425, 32067, 39709, 47351, 54993 anti-HIV-1_LightChain 1500 9142, 16784, 24426, 32068, 39710, 47352, 54994 anti-HIV-1_LightChain 1501 9143, 16785, 24427, 32069, 39711, 47353, 54995 anti-HIV-1_LightChain 1502 9144, 16786, 24428, 32070, 39712, 47354, 54996 anti-HIV-1_LightChain 1503 9145, 16787, 24429, 32071, 39713, 47355, 54997 anti-HIV-1_LightChain 1504 9146, 16788, 24430, 32072, 39714, 47356, 54998 anti-HIV-1_LightChain 1505 9147, 16789, 24431, 32073, 39715, 47357, 54999 anti-HIV-1_LightChain 1506 9148, 16790, 24432, 32074, 39716, 47358, 55000 anti-HIV-1_LightChain 1507 9149, 16791, 24433, 32075, 39717, 47359, 55001 anti-HIV-1_LightChain 1508 9150, 16792, 24434, 32076, 39718, 47360, 55002 anti-HIV-1_LightChain 1509 9151, 16793, 24435, 32077, 39719, 47361, 55003 anti-HIV-1_LightChain 1510 9152, 16794, 24436, 32078, 39720, 47362, 55004 anti-HIV-1_LightChain 1511 9153, 16795, 24437, 32079, 39721, 47363, 55005 anti-HIV-1_LightChain 1512 9154, 16796, 24438, 32080, 39722, 47364, 55006 anti-HIV-1_LightChain 1513 9155, 16797, 24439, 32081, 39723, 47365, 55007 anti-HIV-1_LightChain 1514 9156, 16798, 24440, 32082, 39724, 47366, 55008 anti-HIV-1_LightChain 1515 9157, 16799, 24441, 32083, 39725, 47367, 55009 anti-HIV-1_LightChain 1516 9158, 16800, 24442, 32084, 39726, 47368, 55010 anti-HIV-1_LightChain 1517 9159, 16801, 24443, 32085, 39727, 47369, 55011 anti-HIV-1_LightChain 1518 9160, 16802, 24444, 32086, 39728, 47370, 55012 anti-HIV-1_LightChain 1519 9161, 16803, 24445, 32087, 39729, 47371, 55013 anti-HIV-1_LightChain 1520 9162, 16804, 24446, 32088, 39730, 47372, 55014 anti-HIV-1_LightChain 1521 9163, 16805, 24447, 32089, 39731, 47373, 55015 anti-HIV-1_LightChain 1522 9164, 16806, 24448, 32090, 39732, 47374, 55016 anti-HIV-1_LightChain 1523 9165, 16807, 24449, 32091, 39733, 47375, 55017 anti-HIV-1_LightChain 1524 9166, 16808, 24450, 32092, 39734, 47376, 55018 anti-HIV-1_LightChain 1525 9167, 16809, 24451, 32093, 39735, 47377, 55019 anti-HIV-1_LightChain 1526 9168, 16810, 24452, 32094, 39736, 47378, 55020 anti-HIV-1_LightChain 1527 9169, 16811, 24453, 32095, 39737, 47379, 55021 anti-HIV-1_LightChain 1528 9170, 16812, 24454, 32096, 39738, 47380, 55022 anti-HIV-1_LightChain 1529 9171, 16813, 24455, 32097, 39739, 47381, 55023 anti-HIV-1_LightChain 1530 9172, 16814, 24456, 32098, 39740, 47382, 55024 anti-HIV-1_LightChain 1531 9173, 16815, 24457, 32099, 39741, 47383, 55025 anti-HIV-1_LightChain 1532 9174, 16816, 24458, 32100, 39742, 47384, 55026 anti-HIV-1_LightChain 1533 9175, 16817, 24459, 32101, 39743, 47385, 55027 anti-HIV-1_LightChain 1534 9176, 16818, 24460, 32102, 39744, 47386, 55028 anti-HIV-1_LightChain 1535 9177, 16819, 24461, 32103, 39745, 47387, 55029 anti-HIV-1_LightChain 1536 9178, 16820, 24462, 32104, 39746, 47388, 55030 anti-HIV-1_LightChain 1537 9179, 16821, 24463, 32105, 39747, 47389, 55031 anti-HIV-1_LightChain 1538 9180, 16822, 24464, 32106, 39748, 47390, 55032 anti-HIV-1_LightChain 1539 9181, 16823, 24465, 32107, 39749, 47391, 55033 anti-HIV-1_LightChain 1540 9182, 16824, 24466, 32108, 39750, 47392, 55034 anti-HIV-1_LightChain 1541 9183, 16825, 24467, 32109, 39751, 47393, 55035 anti-HIV-1_LightChain 1542 9184, 16826, 24468, 32110, 39752, 47394, 55036 anti-HIV-1_LightChain 1543 9185, 16827, 24469, 32111, 39753, 47395, 55037 anti-HIV-1_LightChain 1544 9186, 16828, 24470, 32112, 39754, 47396, 55038 anti-HIV-1_LightChain 1545 9187, 16829, 24471, 32113, 39755, 47397, 55039 anti-HIV-1_LightChain 1546 9188, 16830, 24472, 32114, 39756, 47398, 55040 anti-HIV-1_LightChain 1547 9189, 16831, 24473, 32115, 39757, 47399, 55041 anti-HIV-1_LightChain 1548 9190, 16832, 24474, 32116, 39758, 47400, 55042 anti-HIV-1_LightChain 1549 9191, 16833, 24475, 32117, 39759, 47401, 55043 anti-HIV-1_LightChain 1550 9192, 16834, 24476, 32118, 39760, 47402, 55044 anti-HIV-1_LightChain 1551 9193, 16835, 24477, 32119, 39761, 47403, 55045 anti-HIV-1_LightChain 1552 9194, 16836, 24478, 32120, 39762, 47404, 55046 anti-HIV-1_LightChain 1553 9195, 16837, 24479, 32121, 39763, 47405, 55047 anti-HIV-1_LightChain 1554 9196, 16838, 24480, 32122, 39764, 47406, 55048 anti-HIV-1_LightChain 1555 9197, 16839, 24481, 32123, 39765, 47407, 55049 anti-HIV-1_LightChain 1556 9198, 16840, 24482, 32124, 39766, 47408, 55050 anti-HIV-1_LightChain 1557 9199, 16841, 24483, 32125, 39767, 47409, 55051 anti-HIV-1_LightChain 1558 9200, 16842, 24484, 32126, 39768, 47410, 55052 anti-HIV-1_LightChain 1559 9201, 16843, 24485, 32127, 39769, 47411, 55053 anti-HIV-1_LightChain 1560 9202, 16844, 24486, 32128, 39770, 47412, 55054 anti-HIV-1_LightChain 1561 9203, 16845, 24487, 32129, 39771, 47413, 55055 anti-HIV-1_LightChain 1562 9204, 16846, 24488, 32130, 39772, 47414, 55056 anti-HIV-1_LightChain 1563 9205, 16847, 24489, 32131, 39773, 47415, 55057 anti-HIV-1_LightChain 1564 9206, 16848, 24490, 32132, 39774, 47416, 55058 anti-HIV-1_LightChain 1565 9207, 16849, 24491, 32133, 39775, 47417, 55059 anti-HIV-1_LightChain 1566 9208, 16850, 24492, 32134, 39776, 47418, 55060 anti-HIV-1_LightChain 1567 9209, 16851, 24493, 32135, 39777, 47419, 55061 anti-HIV-1_LightChain 1568 9210, 16852, 24494, 32136, 39778, 47420, 55062 anti-HIV-1_LightChain 1569 9211, 16853, 24495, 32137, 39779, 47421, 55063 anti-HIV-1_LightChain 1570 9212, 16854, 24496, 32138, 39780, 47422, 55064 anti-HIV-1_LightChain 1571 9213, 16855, 24497, 32139, 39781, 47423, 55065 anti-HIV-1_LightChain 1572 9214, 16856, 24498, 32140, 39782, 47424, 55066 anti-HIV-1_LightChain 1573 9215, 16857, 24499, 32141, 39783, 47425, 55067 anti-HIV-1_LightChain 1574 9216, 16858, 24500, 32142, 39784, 47426, 55068 anti-HIV-1_LightChain 1575 9217, 16859, 24501, 32143, 39785, 47427, 55069 anti-HIV-1_LightChain 1576 9218, 16860, 24502, 32144, 39786, 47428, 55070 anti-HIV-1_LightChain 1577 9219, 16861, 24503, 32145, 39787, 47429, 55071 anti-HIV-1_LightChain 1578 9220, 16862, 24504, 32146, 39788, 47430, 55072 anti-HIV-1_LightChain 1579 9221, 16863, 24505, 32147, 39789, 47431, 55073 anti-HIV-1_LightChain 1580 9222, 16864, 24506, 32148, 39790, 47432, 55074 anti-HIV-1_LightChain 1581 9223, 16865, 24507, 32149, 39791, 47433, 55075 anti-HIV-1_LightChain 1582 9224, 16866, 24508, 32150, 39792, 47434, 55076 anti-HIV-1_LightChain 1583 9225, 16867, 24509, 32151, 39793, 47435, 55077 anti-HIV-1_LightChain 1584 9226, 16868, 24510, 32152, 39794, 47436, 55078 anti-HIV-1_LightChain 1585 9227, 16869, 24511, 32153, 39795, 47437, 55079 anti-HIV-1_LightChain 1586 9228, 16870, 24512, 32154, 39796, 47438, 55080 anti-HIV-1_LightChain 1587 9229, 16871, 24513, 32155, 39797, 47439, 55081 anti-HIV-1_LightChain 1588 9230, 16872, 24514, 32156, 39798, 47440, 55082 anti-HIV-1_LightChain 1589 9231, 16873, 24515, 32157, 39799, 47441, 55083 anti-HIV-1_LightChain 1590 9232, 16874, 24516, 32158, 39800, 47442, 55084 anti-HIV-1_LightChain 1591 9233, 16875, 24517, 32159, 39801, 47443, 55085 anti-HIV-1_LightChain 1592 9234, 16876, 24518, 32160, 39802, 47444, 55086 anti-HIV-1_LightChain 1593 9235, 16877, 24519, 32161, 39803, 47445, 55087 anti-HIV-1_LightChain 1594 9236, 16878, 24520, 32162, 39804, 47446, 55088 anti-HIV-1_LightChain 1595 9237, 16879, 24521, 32163, 39805, 47447, 55089 anti-HIV-1_LightChain 1596 9238, 16880, 24522, 32164, 39806, 47448, 55090 anti-HIV-1_LightChain 1597 9239, 16881, 24523, 32165, 39807, 47449, 55091 anti-HIV-1_LightChain 1598 9240, 16882, 24524, 32166, 39808, 47450, 55092 anti-HIV-1_LightChain 1599 9241, 16883, 24525, 32167, 39809, 47451, 55093 anti-HIV-1_LightChain 1600 9242, 16884, 24526, 32168, 39810, 47452, 55094 anti-HIV-1_LightChain 1601 9243, 16885, 24527, 32169, 39811, 47453, 55095 anti-HIV-1_LightChain 1602 9244, 16886, 24528, 32170, 39812, 47454, 55096 anti-HIV-1_LightChain 1603 9245, 16887, 24529, 32171, 39813, 47455, 55097 anti-HIV-1_LightChain 1604 9246, 16888, 24530, 32172, 39814, 47456, 55098 anti-HIV-1_LightChain 1605 9247, 16889, 24531, 32173, 39815, 47457, 55099 anti-HIV-1_LightChain 1606 9248, 16890, 24532, 32174, 39816, 47458, 55100 anti-HIV-1_LightChain 1607 9249, 16891, 24533, 32175, 39817, 47459, 55101 anti-HIV-1_LightChain 1608 9250, 16892, 24534, 32176, 39818, 47460, 55102 anti-HIV-1_HeavyChain 1609 9251, 16893, 24535, 32177, 39819, 47461, 55103 anti-HIV-1_HeavyChain 1610 9252, 16894, 24536, 32178, 39820, 47462, 55104 anti-HIV-1_HeavyChain 1611 9253, 16895, 24537, 32179, 39821, 47463, 55105 anti-HIV-1_HeavyChain 1612 9254, 16896, 24538, 32180, 39822, 47464, 55106 anti-HIV-1_HeavyChain 1613 9255, 16897, 24539, 32181, 39823, 47465, 55107 anti-HIV-1_HeavyChain 1614 9256, 16898, 24540, 32182, 39824, 47466, 55108 anti-HIV-1_HeavyChain 1615 9257, 16899, 24541, 32183, 39825, 47467, 55109 anti-HIV-1_HeavyChain 1616 9258, 16900, 24542, 32184, 39826, 47468, 55110 anti-HIV-1_HeavyChain 1617 9259, 16901, 24543, 32185, 39827, 47469, 55111 anti-HIV-1_HeavyChain 1618 9260, 16902, 24544, 32186, 39828, 47470, 55112 anti-HIV-1_HeavyChain 1619 9261, 16903, 24545, 32187, 39829, 47471, 55113 anti-HIV-1_HeavyChain 1620 9262, 16904, 24546, 32188, 39830, 47472, 55114 anti-HIV-1_HeavyChain 1621 9263, 16905, 24547, 32189, 39831, 47473, 55115 anti-HIV-1_HeavyChain 1622 9264, 16906, 24548, 32190, 39832, 47474, 55116 anti-HIV-1_HeavyChain 1623 9265, 16907, 24549, 32191, 39833, 47475, 55117 anti-HIV-1_HeavyChain 1624 9266, 16908, 24550, 32192, 39834, 47476, 55118 anti-HIV-1_HeavyChain 1625 9267, 16909, 24551, 32193, 39835, 47477, 55119 anti-HIV-1_HeavyChain 1626 9268, 16910, 24552, 32194, 39836, 47478, 55120 anti-HIV-1_HeavyChain 1627 9269, 16911, 24553, 32195, 39837, 47479, 55121 anti-HIV-1_HeavyChain 1628 9270, 16912, 24554, 32196, 39838, 47480, 55122 anti-HIV-1_HeavyChain 1629 9271, 16913, 24555, 32197, 39839, 47481, 55123 anti-HIV-1_HeavyChain 1630 9272, 16914, 24556, 32198, 39840, 47482, 55124 anti-HIV-1_HeavyChain 1631 9273, 16915, 24557, 32199, 39841, 47483, 55125 anti-HIV-1_HeavyChain 1632 9274, 16916, 24558, 32200, 39842, 47484, 55126 anti-HIV-1_HeavyChain 1633 9275, 16917, 24559, 32201, 39843, 47485, 55127 anti-HIV-1_HeavyChain 1634 9276, 16918, 24560, 32202, 39844, 47486, 55128 anti-HIV-1_HeavyChain 1635 9277, 16919, 24561, 32203, 39845, 47487, 55129 anti-HIV-1_HeavyChain 1636 9278, 16920, 24562, 32204, 39846, 47488, 55130 anti-HIV-1_HeavyChain 1637 9279, 16921, 24563, 32205, 39847, 47489, 55131 anti-HIV-1_HeavyChain 1638 9280, 16922, 24564, 32206, 39848, 47490, 55132 anti-HIV-1_HeavyChain 1639 9281, 16923, 24565, 32207, 39849, 47491, 55133 anti-HIV-1_HeavyChain 1640 9282, 16924, 24566, 32208, 39850, 47492, 55134 anti-HIV-1_HeavyChain 1641 9283, 16925, 24567, 32209, 39851, 47493, 55135 anti-HIV-1_HeavyChain 1642 9284, 16926, 24568, 32210, 39852, 47494, 55136 anti-HIV-1_HeavyChain 1643 9285, 16927, 24569, 32211, 39853, 47495, 55137 anti-HIV-1_HeavyChain 1644 9286, 16928, 24570, 32212, 39854, 47496, 55138 anti-HIV-1_HeavyChain 1645 9287, 16929, 24571, 32213, 39855, 47497, 55139 anti-HIV-1_HeavyChain 1646 9288, 16930, 24572, 32214, 39856, 47498, 55140 anti-HIV-1_HeavyChain 1647 9289, 16931, 24573, 32215, 39857, 47499, 55141 anti-HIV-1_HeavyChain 1648 9290, 16932, 24574, 32216, 39858, 47500, 55142 anti-HIV-1_HeavyChain 1649 9291, 16933, 24575, 32217, 39859, 47501, 55143 anti-HIV-1_HeavyChain 1650 9292, 16934, 24576, 32218, 39860, 47502, 55144 anti-HIV-1_HeavyChain 1651 9293, 16935, 24577, 32219, 39861, 47503, 55145 anti-HIV-1_HeavyChain 1652 9294, 16936, 24578, 32220, 39862, 47504, 55146 anti-HIV-1_HeavyChain 1653 9295, 16937, 24579, 32221, 39863, 47505, 55147 anti-HIV-1_HeavyChain 1654 9296, 16938, 24580, 32222, 39864, 47506, 55148 anti-HIV-1_HeavyChain 1655 9297, 16939, 24581, 32223, 39865, 47507, 55149 anti-HIV_C38-VRC18.02_HeavyChain 1656 9298, 16940, 24582, 32224, 39856, 47508, 55150 anti-HIV_44-VRC13.02_HeavyChain 1657 9299, 16941, 24583, 32225, 39867, 47509, 55151 anti-HIV-1_LightChain 1658 9300, 16942, 24584, 32226, 39868, 47510, 55152 anti-HIV-1_LightChain 1659 9301, 16943, 24585, 32227, 39869, 47511, 55153 anti-HIV-1_LightChain 1660 9302, 16944, 24586, 32228, 39870, 47512, 55154 anti-HIV-1_LightChain 1661 9303, 16945, 24587, 32229, 39871, 47513, 55155 anti-HIV-1_LightChain 1662 9304, 16946, 24588, 32230, 39872, 47514, 55156 anti-HIV-1_LightChain 1663 9305, 16947, 24589, 32231, 39873, 47515, 55157 anti-HIV-1_LightChain 1664 9306, 16948, 24590, 32232, 39874, 47516, 55158 anti-HIV-1_HeavyChain 1665 9307, 16949, 24591, 32233, 39875, 47517, 55159 anti-HIV-1_HeavyChain 1666 9308, 16950, 24592, 32234, 39876, 47518, 55160 anti-HIV-1_HeavyChain 1667 9309, 16951, 24593, 32235, 39877, 47519, 55161 anti-HIV-1_HeavyChain 1668 9310, 16952, 24594, 32236, 39878, 47520, 55162 anti-HIV-1_HeavyChain 1669 9311, 16953, 24595, 32237, 39879, 47521, 55163 anti-HIV-1_HeavyChain 1670 9312, 16954, 24596, 32238, 39880, 47522, 55164 anti-HIV-1_HeavyChain 1671 9313, 16955, 24597, 32239, 39881, 47523, 55165 anti-HIV_45_LightChain 1672 9314, 16956, 24598, 32240, 39882, 47524, 55165 anti-HIV_45_LightChain 1673 9315, 16957, 24599, 32241, 39883, 47525, 55167 anti-HIV_45_LightChain 1674 9316, 16958, 24600, 32242, 39884, 47526, 55168 anti-HIV_45_HeavyChain 1675 9317, 16959, 24601, 32243, 39885, 47527, 55169 anti-HIV_45_HeavyChain 1676 9318, 16960, 24602, 32244, 39886, 47528, 55170 anti-HIV_45_HeavyChain 1677 9319, 16961, 24603, 32245, 39887, 47529, 55171 anti-HIV_cap256-206-252885_VR-Chain 1678 9320, 16962, 24604, 32246, 39888, 47530, 55172 anti-HIV_cap256-206-249183_VR-Chain 1679 9321, 16963, 24605, 32247, 39889, 47531, 55173 anti-HIV_cap256-206-220956_VR-Chain 1680 9322, 16964, 24606, 32248, 39890, 47532, 55174 anti-HIV_cap256-206-220629_VR-Chain 1681 9323, 16965, 24607, 32249, 39891, 47533, 55175 anti-HIV_cap256-206-200599_VR-Chain 1682 9324, 16966, 24608, 32250, 39892, 47534, 55176 anti-HIV_cap256-206-186347_VR-Chain 1683 9325, 16967, 24609, 32251, 39893, 47535, 55177 anti-HIV_cap256-206-186226_VR-Chain 1684 9326, 16968, 24610, 32252, 39894, 47536, 55178 anti-HIV_cap256-206-179686_VR-Chain 1685 9327, 16969, 24611, 32253, 39895, 47537, 55179 anti-HIV_cap256-206-173707_VR-Chain 1686 9328, 16970, 24612, 32254, 39896, 47538, 55180 anti-HIV_cap256-206-173339_VR-Chain 1687 9329, 16971, 24613, 32255, 39897, 47539, 55181 anti-HIV_cap256-206-172689_VR-Chain 1688 9330, 16972, 24614, 32256, 39898, 47540, 55182 anti-HIV_cap256-206-162744_VR-Chain 1689 9331, 16973, 24615, 32257, 39899, 47541, 55183 anti-HIV_cap256-206-146057_VR-Chain 1690 9332, 16974, 24616, 32258, 39900, 47542, 55184 anti-HIV_cap256-206-139519_VR-Chain 1691 9333, 16975, 24617, 32259, 39901, 47543, 55185 anti-HIV_cap256-206-136316_VR-Chain 1692 9334, 16976, 24618, 32260, 39902, 47544, 55186 anti-HIV_cap256-206-116098_VR-Chain 1693 9335, 16977, 24619, 32261, 39903, 47545, 55187 anti-HIV_cap256-206-115862_VR-Chain 1694 9336, 16978, 24620, 32262, 39904, 47546, 55188 anti-HIV_cap256-206-107018_VR-Chain 1695 9337, 16979, 24621, 32263, 39905, 47547, 55189 anti-HIV_cap256-206-098644_VR-Chain 1696 9338, 16980, 24622, 32264, 39906, 47548, 55190 anti-HIV_cap256-206-098135_VR-Chain 1697 9339, 16981, 24623, 32265, 39907, 47549, 55191 anti-HIV_cap256-206-096276_VR-Chain 1698 9340, 16982, 24624, 32266, 39908, 47550, 55192 anti-HIV_cap256-206-092794_VR-Chain 1699 9341, 16983, 24625, 32267, 39909, 47551, 55193 anti-HIV_cap256-206-086817_VR-Chain 1700 9342, 16984, 24626, 32268, 39910, 47552, 55194 anti-HIV_cap256-206-086446_VR-Chain 1701 9343, 16985, 24627, 32269, 39911, 47553, 55195 anti-HIV_cap256-206-086180_VR-Chain 1702 9344, 16986, 24628, 32270, 39912, 47554, 55196 anti-HIV_cap256-206-083708_VR-Chain 1703 9345, 16987, 24629, 32271, 39913, 47555, 55197 anti-HIV_cap256-206-079556_VR-Chain 1704 9346, 16988, 24630, 32272, 39914, 47556, 55198 anti-HIV_cap256-206-078657_VR-Chain 1705 9347, 16989, 24631, 32273, 39915, 47557, 55199 anti-HIV_cap256-206-075802_VR-Chain 1706 9348, 16990, 24632, 32274, 39916, 47558, 55200 anti-HIV_cap256-206-069097_VR-Chain 1707 9349, 16991, 24633, 32275, 39917, 47559, 55201 anti-HIV_cap256-206-067758_VR-Chain 1708 9350, 16992, 24634, 32276, 39918, 47560, 55202 anti-HIV_cap256-206-057019_VR-Chain 1709 9351, 16993, 24635, 32277, 39919, 47561, 55203 anti-HIV_cap256-206-055385_VR-Chain 1710 9352, 16994, 24636, 32278, 39920, 47562, 55204 anti-HIV_cap256-206-053187_VR-Chain 1711 9353, 16995, 24637, 32279, 39921, 47563, 55205 anti-HIV_cap256-206-053139_VR-Chain 1712 9354, 16996, 24638, 32280, 39922, 47564, 55206 anti-HIV_cap256-206-050350_VR-Chain 1713 9355, 16997, 24639, 32281, 39923, 47565, 55207 anti-HIV_cap256-206-046207_VR-Chain 1714 9356, 16998, 24640, 32282, 39924, 47566, 55208 anti-HIV_cap256-206-043389_VR-Chain 1715 9357, 16999, 24641, 32283, 39925, 47567, 55209 anti-HIV_cap256-206-042555_VR-Chain 1716 9358, 17000, 24642, 32284, 39926, 47568, 55210 anti-HIV_cap256-206-029720_VR-Chain 1717 9359, 17001, 24643, 32285, 39927, 47596, 55211 anti-HIV_cap256-206-028848_VR-Chain 1718 9360, 17002, 24644, 32286, 39928, 47570, 55212 anti-HIV_cap256-206-027652_VR-Chain 1719 9361, 17003, 24645, 32287, 39929, 47571, 55213 anti-HIV_cap256-206-024075_VR-Chain 1720 9362, 17004, 24646, 32288, 39930, 47572, 55214 anti-HIV_cap256-206-008748_VR-Chain 1721 9363, 17005, 24647, 32289, 39931, 47573, 55215 anti-HIV_cap256-206-008530_VR-Chain 1722 9364, 17009, 24648, 32290, 39932, 47574, 55216 anti-HIV_cap256-176-723043_VR-Chain 1723 9365, 17007, 24649, 32291, 39933, 47575, 55217 anti-HIV_cap256-176-600049_VR-Chain 1724 9366, 17008, 24650, 32292, 39934, 47576, 55218 anti-HIV_cap256-176-531926_VR-Chain 1725 9367, 17009, 24651, 32293, 39935, 47577, 55219 anti-HIV_cap256-176-504134_VR-Chain 1726 9368, 17010, 24652, 32294, 39936, 47578, 55220 anti-HIV_cap256-119-186229_VR-Chain 1727 9369, 17011, 24653, 32295, 39937, 47579, 55221 anti-HIV_cap256-119-183891_VR-Chain 1728 9370, 17012, 24654, 32296, 39938, 47580, 55222 anti-HIV_cap256-119-183631_VR-Chain 1729 9371, 17013, 24655, 32297, 39939, 47581, 55223 anti-HIV_cap256-119-182676_VR-Chain 1730 9372, 17014, 24656, 32298, 39940, 47582, 55224 anti-HIV_cap256-119-180772_VR-Chain 1731 9373, 17015, 24657, 32299, 39941, 47583, 55225 anti-HIV_cap256-119-180508_VR-Chain 1732 9374, 17016, 24658, 32300, 39942, 47584, 55226 anti-HIV_cap256-119-180260_VR-Chain 1733 9375, 17017, 24659, 32301, 39943, 47585, 55227 anti-HIV_cap256-119-180173_VR-Chain 1734 9376, 17018, 24660, 32302, 39944, 47586, 55228 anti-HIV_cap256-119-179839_VR-Chain 1735 9377, 17019, 24661, 32303, 39945, 47587, 55229 anti-HIV_cap256-119-179262_VR-Chain 1736 9378, 17020, 24662, 32304, 39946, 47588, 55230 anti-HIV_cap256-119-178995_VR-Chain 1737 9379, 17021, 24663, 32305, 39947, 47589, 55231 anti-HIV_cap256-119-178455_VR-Chain 1738 9380, 17022, 24664, 32306, 39948, 47590, 55232 anti-HIV_cap256-119-177993_VR-Chain 1739 9381, 17023, 24665, 32307, 39949, 47591, 55233 anti-HIV_cap256-119-177727_VR-Chain 1740 9382, 17024, 24666, 32308, 39950, 47592, 55234 anti-HIV_cap256-119-176746_VR-Chain 1741 9383, 17025, 24667, 32309, 39951, 47593, 55235 anti-HIV_cap256-119-176241_VR-Chain 1742 9384, 17026, 24668, 32310, 39952, 47594, 55236 anti-HIV_cap256-119-175215_VR-Chain 1743 9385, 17027, 24669, 32311, 39953, 47595, 55237 anti-HIV_cap256-119-173928_VR-Chain 1744 9386, 17028, 24670, 32312, 39954, 47596, 55238 anti-HIV_cap256-119-173495_VR-Chain 1745 9387, 17029, 24671, 32313, 39955, 47597, 55239 anti-HIV_cap256-119-172882_VR-Chain 1746 9388, 17030, 24672, 32314, 39956, 47598, 55240 anti-HIV_cap256-119-172429_VR-Chain 1747 9389, 17031, 24673, 32315, 39957, 47599, 55241 anti-HIV_cap256-119-172223_VR-Chain 1748 9390, 17032, 24674, 32316, 39958, 47600, 55242 anti-HIV_cap256-119-171838_VR-Chain 1749 9391, 17033, 24675, 32317, 39959, 47601, 55243 anti-HIV_cap256-119-171587_VR-Chain 1750 9392, 17034, 24676, 32318, 39960, 47602, 55244 anti-HIV_cap256-119-169596_VR-Chain 1751 9393, 17035, 24677, 32319, 39961, 47603, 55245 anti-HIV_cap256-119-169523_VR-Chain 1752 9394, 17036, 24678, 32320, 39962, 47604, 55246 anti-HIV_cap256-119-169462_VR-Chain 1753 9395, 17037, 24679, 32321, 39963, 47605, 55247 anti-HIV_cap256-119-169092_VR-Chain 1754 9396, 17038, 24680, 32322, 39964, 47606, 55248 anti-HIV_cap256-119-168680_VR-Chain 1755 9397, 17039, 24681, 32323, 39965, 47607, 55249 anti-HIV_cap256-119-166385_VR-Chain 1756 9398, 17040, 24682, 32324, 39966, 47608, 55250 anti-HIV_cap256-119-165943_VR-Chain 1757 9399, 17041, 24683, 32325, 39967, 47609, 55251 anti-HIV_cap256-119-165738_VR-Chain 1758 9400, 17042, 24684, 32326, 39968, 47610, 55252 anti-HIV_cap256-119-164913_VR-Chain 1759 9401, 17043, 24685, 32327, 39969, 47611, 55253 anti-HIV_cap256-119-164167_VR-Chain 1760 9402, 17044, 24686, 32328, 39970, 47612, 55254 anti-HIV_cap256-119-163558_VR-Chain 1761 9403, 17045, 24687, 32329, 39971, 47613, 55255 anti-HIV_cap256-119-162043_VR-Chain 1762 9404, 17046, 24688, 32330, 39972, 47614, 55256 anti-HIV_cap256-119-161718_VR-Chain 1763 9405, 17047, 24689, 32331, 39973, 47615, 55257 anti-HIV_cap256-119-161675_VR-Chain 1764 9406, 17048, 24690, 32332, 39974, 47616, 55258 anti-HIV_cap256-119-161053_VR-Chain 1765 9407, 17049, 24691, 32333, 39975, 47617, 55259 anti-HIV_cap256-119-159499_VR-Chain 1766 9408, 17050, 24692, 32334, 39976, 47618, 55260 anti-HIV_cap256-119-159114_VR-Chain 1767 9409, 17051, 24693, 32335, 39977, 47619, 55261 anti-HIV_cap256-119-156751_VR-Chain 1768 9410, 17052, 24694, 32336, 39978, 47620, 55262 anti-HIV_cap256-119-155656_VR-Chain 1769 9411, 17053, 24695, 32337, 39979, 47621, 55263 anti-HIV_cap256-119-154420_VR-Chain 1770 9412, 17054, 24696, 32338, 39980, 47622, 55264 anti-HIV_cap256-119-153954_VR-Chain 1771 9413, 17055, 24697, 32339, 39981, 47623, 55265 anti-HIV_cap256-119-153864_VR-Chain 1772 9414, 17056, 24698, 32340, 39982, 47624, 55266 anti-HIV_cap256-119-153793_VR-Chain 1773 9415, 17057, 24699, 32341, 39983, 47625, 55267 anti-HIV_cap256-119-153462_VR-Chain 1774 9416, 17058, 24700, 32342, 39984, 47626, 55268 anti-HIV_cap256-119-153124_VR-Chain 1775 9417, 17059, 24701, 32343, 39985, 47627, 55269 anti-HIV_cap256-119-153025_VR-Chain 1776 9418, 17060, 24702, 32344, 39986, 47628, 55270 anti-HIV_cap256-119-152713_VR-Chain 1777 9419, 17061, 24703, 32345, 39987, 47629, 55271 anti-HIV_cap256-119-151794_VR-Chain 1778 9420, 17062, 24704, 32346, 39988, 47630, 55272 anti-HIV_cap256-119-150980_VR-Chain 1779 9421, 17063, 24705, 32347, 39989, 47631, 55273 anti-HIV_cap256-119-148895_VR-Chain 1780 9422, 17064, 24706, 32348, 39990, 47632, 55274 anti-HIV_cap256-119-148848_VR-Chain 1781 9423, 17065, 24707, 32349, 39991, 47633, 55275 anti-HIV_cap256-119-148743_VR-Chain 1782 9424, 17066, 24708, 32350, 39992, 47634, 55276 anti-HIV_cap256-119-148595_VR-Chain 1783 9425, 17067, 24709, 32351, 39993, 47635, 55277 anti-HIV_cap256-119-148490_VR-Chain 1784 9426, 17068, 24710, 32352, 39994, 47636, 55278 anti-HIV_cap256-119-148470_VR-Chain 1785 9427, 17069, 24711, 32353, 39995, 47637, 55279 anti-HIV_cap256-119-148107_VR-Chain 1786 9428, 17070, 24712, 32354, 39996, 47638, 55280 anti-HIV_cap256-119-147933_VR-Chain 1787 9429, 17071, 24713, 32355, 39997, 47639, 55281 anti-HIV_cap256-119-147434_VR-Chain 1788 9430, 17072, 24714, 32356, 39998, 47640, 55282 anti-HIV_cap256-119-146106_VR-Chain 1789 9431, 17073, 24715, 32357, 39999, 47641, 55283 anti-HIV_cap256-119-145604_VR-Chain 1790 9432, 17074, 24716, 32358, 40000, 47642, 55284 anti-HIV_cap256-119-143998_VR-Chain 1791 9433, 17075, 24717, 32359, 40001, 47643, 55285 anti-HIV_cap256-119-143441_VR-Chain 1792 9434, 17076, 24718, 32360, 40002, 47644, 55286 anti-HIV_cap256-119-141307_VR-Chain 1793 9435, 17077, 24719, 32361, 40003, 47645, 55287 anti-HIV_cap256-119-140896_VR-Chain 1794 9436, 17078, 24720, 32362, 40004, 47646, 55288 anti-HIV_cap256-119-140090_VR-Chain 1795 9437, 17079, 24721, 32363, 40005, 47647, 55289 anti-HIV_cap256-119-140037_VR-Chain 1796 9438, 17080, 24722, 32364, 40006, 47648, 55290 anti-HIV_cap256-119-139135_VR-Chain 1797 9439, 17081, 24723, 32365, 40007, 47649, 55291 anti-HIV_cap256-119-137881_VR-Chain 1798 9440, 17082, 24724, 32366, 40008, 47650, 55292 anti-HIV_cap256-119-137643_VR-Chain 1799 9441, 17083, 24725, 32367, 40009, 47651, 55293 anti-HIV_cap256-119-137170_VR-Chain 1800 9442, 17084, 24726, 32368, 40010, 47652, 55294 anti-HIV_cap256-119-136616_VR-Chain 1801 9443, 17085, 24727, 32369, 40011, 47653, 55295 anti-HIV_cap256-119-136206_VR-Chain 1802 9444, 17086, 24728, 32370, 40012, 47654, 55296 anti-HIV_cap256-119-135565_VR-Chain 1803 9445, 17087, 24729, 32371, 40013, 47655, 55297 anti-HIV_cap256-119-135025_VR-Chain 1804 9446, 17088, 24730, 32372, 40014, 47656, 55298 anti-HIV_cap256-119-133983_VR-Chain 1805 9447, 17089, 24731, 32373, 40015, 47657, 55299 anti-HIV_cap256-119-133917_VR-Chain 1806 9448, 17090, 24732, 32374, 40016, 47658, 55300 anti-HIV_cap256-119-132663_VR-Chain 1807 9449, 17091, 24733, 32375, 40017, 47659, 55301 anti-HIV_cap256-119-132113_VR-Chain 1808 9450, 17092, 24734, 32376, 40018, 47660, 55302 anti-HIV_cap256-119-131839_VR-Chain 1809 9451, 17093, 24735, 32377, 40019, 47661, 55303 anti-HIV_cap256-119-130626_VR-Chain 1810 9452, 17094, 24736, 32378, 40020, 47662, 55304 anti-HIV_cap256-119-130191_VR-Chain 1811 9453, 17095, 24737, 32379, 40021, 47663, 55305 anti-HIV_cap256-119-129798_VR-Chain 1812 9454, 17096, 24738, 32380, 40022, 47664, 55306 anti-HIV_cap256-119-128745_VR-Chain 1813 9455, 17097, 24739, 32381, 40023, 47665, 55307 anti-HIV_cap256-119-128593_VR-Chain 1814 9456, 17098, 24740, 32382, 40024, 47666, 55308 anti-HIV_cap256-119-128152_VR-Chain 1815 9457, 17099, 24741, 32383, 40025, 47667, 55309 anti-HIV_cap256-119-127693_VR-Chain 1816 9458, 17100, 24742, 32384, 40026, 47668, 55310 anti-HIV_cap256-119-126684_VR-Chain 1817 9459, 17101, 24743, 32385, 40027, 47669, 55311 anti-HIV_cap256-119-126056_VR-Chain 1818 9460, 17102, 24744, 32386, 40028, 47670, 55312 anti-HIV_cap256-119-125765_VR-Chain 1819 9461, 17103, 24745, 32387, 40029, 47671, 55313 anti-HIV_cap256-119-125106_VR-Chain 1820 9462, 17104, 24746, 32388, 40030, 47672, 55314 anti-HIV_cap256-119-124026_VR-Chain 1821 9463, 17105, 24747, 32389, 40031, 47673, 55315 anti-HIV_cap256-119-121783_VR-Chain 1822 9464, 17106, 24748, 32390, 40032, 47674, 55316 anti-HIV_cap256-119-121208_VR-Chain 1823 9465, 17107, 24749, 32391, 40033, 47675, 55317 anti-HIV_cap256-119-120945_VR-Chain 1824 9466, 17108, 24750, 32392, 40034, 47676, 55318 anti-HIV_cap256-119-118229_VR-Chain 1825 9467, 17109, 24751, 32393, 40035, 47677, 55319 anti-HIV_cap256-119-118025_VR-Chain 1826 9468, 17110, 24752, 32394, 40036, 47678, 55320 anti-HIV_cap256-119-117418_VR-Chain 1827 9469, 17111, 24753, 32395, 40037, 47679, 55321 anti-HIV_cap256-119-117250_VR-Chain 1828 9470, 17112, 24754, 32396, 40038, 47680, 55322 anti-HIV_cap256-119-117230_VR-Chain 1829 9471, 17113, 24755, 32397, 40039, 47681, 55323 anti-HIV_cap256-119-116999_VR-Chain 1830 9472, 17114, 24756, 32398, 40040, 47682, 55324 anti-HIV_cap256-119-116558_VR-Chain 1831 9473, 17115, 24757, 32399, 40041, 47683, 55325 anti-HIV_cap256-119-116484_VR-Chain 1832 9474, 17116, 24758, 32400, 40042, 47684, 55326 anti-HIV_cap256-119-114844_VR-Chain 1833 9475, 17117, 24759, 32401, 40043, 47685, 55327 anti-HIV_cap256-119-114141_VR-Chain 1834 9476, 17118, 24760, 32402, 40044, 47686, 55328 anti-HIV_cap256-119-111917_VR-Chain 1835 9477, 17119, 24761, 32403, 40045, 47687, 55329 anti-HIV_cap256-119-111862_VR-Chain 1836 9478, 17120, 24762, 32404, 40046, 47688, 55330 anti-HIV_cap256-119-110064_VR-Chain 1837 9479, 17121, 24763, 32405, 40047, 47689, 55331 anti-HIV_cap256-119-109192_VR-Chain 1838 9480, 17122, 24764, 32406, 40048, 47690, 55332 anti-HIV_cap256-119-108793_VR-Chain 1839 9481, 17123, 24765, 32407, 40049, 47691, 55333 anti-HIV_cap256-119-108127_VR-Chain 1840 9482, 17124, 24766, 32408, 40050, 47692, 55334 anti-HIV_cap256-119-107758_VR-Chain 1841 9483, 17125, 24767, 32409, 40051, 47693, 55335 anti-HIV_cap256-119-107209_VR-Chain 1842 9484, 17126, 24768, 32410, 40052, 47694, 55336 anti-HIV_cap256-119-107184_VR-Chain 1843 9485, 17127, 24769, 32411, 40053, 47695, 55337 anti-HIV_cap256-119-106827_VR-Chain 1844 9486, 17128, 24770, 32412, 40054, 47696, 55338 anti-HIV_cap256-119-106511_VR-Chain 1845 9487, 17129, 24771, 32413, 40055, 47697, 55339 anti-HIV_cap256-119-106327_VR-Chain 1846 9488, 17130, 24772, 32414, 40056, 47698, 55340 anti-HIV_cap256-119-105486_VR-Chain 1847 9489, 17131, 24773, 32415, 40057, 47699, 55341 anti-HIV_cap256-119-105197_VR-Chain 1848 9490, 17132, 24774, 32416, 40058, 47700, 55342 anti-HIV_cap256-119-104946_VR-Chain 1849 9491, 17133, 24775, 32417, 40059, 47701, 55343 anti-HIV_cap256-119-103667_VR-Chain 1850 9492, 17134, 24776, 32418, 40060, 47702, 55344 anti-HIV_cap256-119-103385_VR-Chain 1851 9493, 17135, 24777, 32419, 40061, 47703, 55345 anti-HIV_cap256-119-103267_VR-Chain 1852 9494, 17136, 24778, 32420, 40062, 47704, 55346 anti-HIV_cap256-119-103011_VR-Chain 1853 9495, 17137, 24779, 32421, 40063, 47705, 55347 anti-HIV_cap256-119-102072_VR-Chain 1854 9496, 17138, 24780, 32422, 40064, 47706, 55348 anti-HIV_cap256-119-101945_VR-Chain 1855 9497, 17139, 24781, 32423, 40065, 47707, 55349 anti-HIV_cap256-119-101319_VR-Chain 1856 9498, 17140, 24782, 32424, 40066, 47708, 55350 anti-HIV_cap256-119-100871_VR-Chain 1857 9499, 17141, 24783, 32425, 40067, 47709, 55351 anti-HIV_cap256-119-100838_VR-Chain 1858 9500, 17142, 24784, 32426, 40068, 47710, 55352 anti-HIV_cap256-119-100025_VR-Chain 1859 9501, 17143, 24785, 32427, 40069, 47711, 55353 anti-HIV_cap256-119-100000_VR-Chain 1860 9502, 17144, 24786, 32428, 40070, 47712, 55354 anti-HIV_cap256-119-098890_VR-Chain 1861 9503, 17145, 24787, 32429, 40071, 47713, 55355 anti-HIV_cap256-119-098715_VR-Chain 1862 9504, 17146, 24788, 32430, 40072, 47714, 55356 anti-HIV_cap256-119-098632_VR-Chain 1863 9505, 17147, 24789, 32431, 40073, 47715, 55357 anti-HIV_cap256-119-097199_VR-Chain 1864 9506, 17148, 24790, 32432, 40074, 47716, 55358 anti-HIV_cap256-119-096189_VR-Chain 1865 9507, 17149, 24791, 32433, 40075, 47717, 55359 anti-HIV_cap256-119-094581_VR-Chain 1866 9508, 17150, 24792, 32434, 40076, 47718, 55360 anti-HIV_cap256-119-094200_VR-Chain 1867 9509, 17151, 24793, 32435, 40077, 47719, 55361 anti-HIV_cap256-119-094158_VR-Chain 1868 9510, 17152, 24794, 32436, 40078, 47720, 55362 anti-HIV_cap256-119-092814_VR-Chain 1869 9511, 17153, 24795, 32437, 40079, 47721, 55363 anti-HIV_cap256-119-092808_VR-Chain 1870 9512, 17154, 24796, 32438, 40080, 47722, 55364 anti-HIV_cap256-119-092573_VR-Chain 1871 9513, 17155, 24797, 32439, 40081, 47723, 55365 anti-HIV_cap256-119-090815_VR-Chain 1872 9514, 17156, 24798, 32440, 40082, 47724, 55366 anti-HIV_cap256-119-090368_VR-Chain 1873 9515, 17157, 24799, 32441, 40083, 47725, 55367 anti-HIV_cap256-119-089710_VR-Chain 1874 9516, 17158, 24800, 32442, 40084, 47726, 55368 anti-HIV_cap256-119-088555_VR-Chain 1875 9517, 17159, 24801, 32443, 40085, 47727, 55369 anti-HIV_cap256-119-087962_VR-Chain 1876 9518, 17160, 24802, 32444, 40086, 47728, 55370 anti-HIV_cap256-119-086903_VR-Chain 1877 9519, 17161, 24803, 32445, 40087, 47729, 55371 anti-HIV_cap256-119-086804_VR-Chain 1878 9520, 17162, 24804, 32446, 40088, 47730, 55372 anti-HIV_cap256-119-085910_VR-Chain 1879 9521, 17163, 24805, 32447, 40089, 47731, 55373 anti-HIV_cap256-119-085772_VR-Chain 1880 9522, 17164, 24806, 32448, 40090, 47732, 55374 anti-HIV_cap256-119-084603_VR-Chain 1881 9523, 17165, 24807, 32449, 40091, 47733, 55375 anti-HIV_cap256-119-084276_VR-Chain 1882 9524, 17166, 24808, 32450, 40092, 47734, 55376 anti-HIV_cap256-119-082288_VR-Chain 1883 9525, 17167, 24809, 32451, 40093, 47735, 55377 anti-HIV_cap256-119-080383_VR-Chain 1884 9526, 17168, 24810, 32452, 40094, 47736, 55378 anti-HIV_cap256-119-079333_VR-Chain 1885 9527, 17169, 24811, 32453, 40095, 47737, 55379 anti-HIV_cap256-119-078618_VR-Chain 1886 9528, 17170, 24812, 32454, 40096, 47738, 55380 anti-HIV_cap256-119-077466_VR-Chain 1887 9529, 17171, 24813, 32455, 40097, 47739, 55381 anti-HIV_cap256-119-076284_VR-Chain 1888 9530, 17172, 24814, 32456, 40098, 47740, 55382 anti-HIV_cap256-119-074680_VR-Chain 1889 9531, 17173, 24815, 32457, 40099, 47741, 55383 anti-HIV_cap256-119-074081_VR-Chain 1890 9532, 17174, 24816, 32458, 40100, 47742, 55384 anti-HIV_cap256-119-071704_VR-Chain 1891 9533, 17175, 24817, 32459, 40101, 47743, 55385 anti-HIV_cap256-119-071266_VR-Chain 1892 9534, 17176, 24818, 32460, 40102, 47744, 55386 anti-HIV_cap256-119-069667_VR-Chain 1893 9535, 17177, 24819, 32461, 40103, 47745, 55387 anti-HIV_cap256-119-069591_VR-Chain 1894 9536, 17178, 24820, 32462, 40104, 47746, 55388 anti-HIV_cap256-119-068691_VR-Chain 1895 9537, 17179, 24821, 32463, 40105, 47747, 55389 anti-HIV_cap256-119-068488_VR-Chain 1896 9538, 17180, 24822, 32464, 40106, 47748, 55390 anti-HIV_cap256-119-067536_VR-Chain 1897 9539, 17181, 24823, 32465, 40107, 47749, 55391 anti-HIV_cap256-119-065852_VR-Chain 1898 9540, 17182, 24824, 32466, 40108, 47750, 55392 anti-HIV_cap256-119-065457_VR-Chain 1899 9541, 17183, 24825, 32467, 40109, 47751, 55393 anti-HIV_cap256-119-064501_VR-Chain 1900 9542, 17184, 24826, 32468, 40110, 47752, 55394 anti-HIV_cap256-119-063568_VR-Chain 1901 9543, 17185, 24827, 32469, 40111, 47753, 55395 anti-HIV_cap256-119-063103_VR-Chain 1902 9544, 17186, 24828, 32470, 40112, 47754, 55396 anti-HIV_cap256-119-061027_VR-Chain 1903 9545, 17187, 24829, 32471, 40113, 47755, 55397 anti-HIV_cap256-119-058232_VR-Chain 1904 9546, 17188, 24830, 32472, 40114, 47756, 55398 anti-HIV_cap256-119-057341_VR-Chain 1905 9547, 17189, 24831, 32473, 40115, 47757, 55399 anti-HIV_cap256-119-056895_VR-Chain 1906 9548, 17190, 24832, 32474, 40116, 47758, 55400 anti-HIV_cap256-119-056402_VR-Chain 1907 9549, 17191, 24833, 32475, 40117, 47759, 55401 anti-HIV_cap256-119-056034_VR-Chain 1908 9550, 17192, 24834, 32476, 40118, 47760, 55402 anti-HIV_cap256-119-055042_VR-Chain 1909 9551, 17193, 24835, 32477, 40119, 47761, 55403 anti-HIV_cap256-119-054776_VR-Chain 1910 9552, 17194, 24836, 32478, 40120, 47762, 55404 anti-HIV_cap256-119-054539_VR-Chain 1911 9553, 17195, 24837, 32479, 40121, 47763, 55405 anti-HIV_cap256-119-054112_VR-Chain 1912 9554, 17199, 24838, 32480, 40122, 47764, 55406 anti-HIV_cap256-119-053339_VR-Chain 1913 9555, 17197, 24839, 32481, 40123, 47765, 55407 anti-HIV_cap256-119-052404_VR-Chain 1914 9556, 17198, 24840, 32482, 40124, 47766, 55408 anti-HIV_cap256-119-051123_VR-Chain 1915 9557, 17199, 24841, 32483, 40125, 47767, 55409 anti-HIV_cap256-119-051077_VR-Chain 1916 9558, 17200, 24842, 32484, 40126, 47768, 55410 anti-HIV_cap256-119-050442_VR-Chain 1917 9559, 17201, 24843, 32485, 40127, 47769, 55411 anti-HIV_cap256-119-049433_VR-Chain 1918 9560, 17202, 24844, 32486, 40128, 47770, 55412 anti-HIV_cap256-119-047532_VR-Chain 1919 9561, 17203, 24845, 32487, 40129, 47771, 55413 anti-HIV_cap256-119-047489_VR-Chain 1920 9562, 17204, 24846, 32488, 40130, 47772, 55414 anti-HIV_cap256-119-046020_VR-Chain 1921 9563, 17205, 24847, 32489, 40131, 47773, 55415 anti-HIV_cap256-119-044746_VR-Chain 1922 9564, 17206, 24848, 32490, 40132, 47774, 55416 anti-HIV_cap256-119-044740_VR-Chain 1923 9565, 17207, 24849, 32491, 40133, 47775, 55417 anti-HIV_cap256-119-043790_VR-Chain 1924 9566, 17208, 24850, 32492, 40134, 47776, 55418 anti-HIV_cap256-119-042880_VR-Chain 1925 9567, 17209, 24851, 32493, 40135, 47777, 55419 anti-HIV_cap256-119-042606_VR-Chain 1926 9568, 17210, 24852, 32494, 40136, 47778, 55420 anti-HIV_cap256-119-042444_VR-Chain 1927 9569, 17211, 24853, 32495, 40137, 47779, 55421 anti-HIV_cap256-119-040328_VR-Chain 1928 9570, 17212, 24854, 32496, 40138, 47780, 55422 anti-HIV_cap256-119-040164_VR-Chain 1929 9571, 17213, 24855, 32497, 40139, 47781, 55423 anti-HIV_cap256-119-039130_VR-Chain 1930 9572, 17214, 24856, 32498, 40140, 47782, 55424 anti-HIV_cap256-119-038138_VR-Chain 1931 9573, 17215, 24857, 32499, 40141, 47783, 55425 anti-HIV_cap256-119-037868_VR-Chain 1932 9574, 17216, 24858, 32500, 40142, 47784, 55426 anti-HIV_cap256-119-037102_VR-Chain 1933 9575, 17217, 24859, 32501, 40143, 47785, 55427 anti-HIV_cap256-119-036683_VR-Chain 1934 9576, 17218, 24860, 32502, 40144, 47786, 55428 anti-HIV_cap256-119-036495_VR-Chain 1935 9577, 17219, 24861, 32503, 40145, 47787, 55429 anti-HIV_cap256-119-035375_VR-Chain 1936 9578, 17220, 24862, 32504, 40146, 47788, 55430 anti-HIV_cap256-119-035165_VR-Chain 1937 9579, 17221, 24863, 32505, 40147, 47789, 55431 anti-HIV_cap256-119-035109_VR-Chain 1938 9580, 17222, 24864, 32506, 40148, 47790, 55432 anti-HIV_cap256-119-033789_VR-Chain 1939 9581, 17223, 24865, 32507, 40149, 47791, 55433 anti-HIV_cap256-119-033641_VR-Chain 1940 9582, 17224, 24866, 32508, 40150, 47792, 55434 anti-HIV_cap256-119-032113_VR-Chain 1941 9583, 17225, 24867, 32509, 40151, 47793, 55435 anti-HIV_cap256-119-031739_VR-Chain 1942 9584, 17226, 24868, 32510, 40152, 47794, 55436 anti-HIV_cap256-119-030932_VR-Chain 1943 9585, 17227, 24869, 32511, 40153, 47795, 55437 anti-HIV_cap256-119-030740_VR-Chain 1944 9586, 17228, 24870, 32512, 40154, 47796, 55438 anti-HIV_cap256-119-030197_VR-Chain 1945 9587, 17229, 24871, 32513, 40155, 47797, 55439 anti-HIV_cap256-119-027047_VR-Chain 1946 9588, 17230, 24872, 32514, 40156, 47798, 55440 anti-HIV_cap256-119-026950_VR-Chain 1947 9589, 17231, 24873, 32515, 40157, 47799, 55441 anti-HIV_cap256-119-026279_VR-Chain 1948 9590, 17232, 24874, 32516, 40158, 47800, 55442 anti-HIV_cap256-119-025355_VR-Chain 1949 9591, 17233, 24875, 32517, 40159, 47801, 55443 anti-HIV_cap256-119-025301_VR-Chain 1950 9592, 17234, 24876, 32518, 40160, 47802, 55444 anti-HIV_cap256-119-025010_VR-Chain 1951 9593, 17235, 24877, 32519, 40161, 47803, 55445 anti-HIV_cap256-119-024631_VR-Chain 1952 9594, 17236, 24878, 32520, 40162, 47804, 55446 anti-HIV_cap256-119-024467_VR-Chain 1953 9595, 17237, 24879, 32521, 40163, 47805, 55447 anti-HIV_cap256-119-023805_VR-Chain 1954 9596, 17238, 24880, 32522, 40164, 47806, 55448 anti-HIV_cap256-119-021736_VR-Chain 1955 9597, 17239, 24881, 32523, 40165, 47807, 55449 anti-HIV_cap256-119-021203_VR-Chain 1956 9598, 17240, 24882, 32524, 40166, 47808, 55450 anti-HIV_cap256-119-020569_VR-Chain 1957 9599, 17241, 24883, 32525, 40167, 47809, 55451 anti-HIV_cap256-119-019432_VR-Chain 1958 9600, 17242, 24884, 32526, 40168, 47810, 55452 anti-HIV_cap256-119-018827_VR-Chain 1959 9601, 17243, 24885, 32527, 40169, 47811, 55453 anti-HIV_cap256-119-018483_VR-Chain 1960 9602, 17244, 24886, 32528, 40170, 47812, 55454 anti-HIV_cap256-119-018118_VR-Chain 1961 9603, 17245, 24887, 32529, 40171, 47813, 55455 anti-HIV_cap256-119-017782_VR-Chain 1962 9604, 17246, 24888, 32530, 40172, 47814, 55456 anti-HIV_cap256-119-017669_VR-Chain 1963 9605, 17247, 24889, 32531, 40173, 47815, 55457 anti-HIV_cap256-119-016976_VR-Chain 1964 9606, 17248, 24890, 32532, 40174, 47816, 55458 anti-HIV_cap256-119-015432_VR-Chain 1965 9607, 17249, 24891, 32533, 40175, 47817, 55459 anti-HIV_cap256-119-015281_VR-Chain 1966 9608, 17250, 24892, 32534, 40176, 47818, 55460 anti-HIV_cap256-119-014957_VR-Chain 1967 9609, 17251, 24893, 32535, 40177, 47819, 55461 anti-HIV_cap256-119-014777_VR-Chain 1968 9610, 17252, 24894, 32536, 40178, 47820, 55462 anti-HIV_cap256-119-014313_VR-Chain 1969 9611, 17253, 24895, 32537, 40179, 47821, 55463 anti-HIV_cap256-119-014219_VR-Chain 1970 9612, 17254, 24896, 32538, 40180, 47822, 55464 anti-HIV_cap256-119-013631_VR-Chain 1971 9613, 17255, 24897, 32539, 40181, 47823, 55465 anti-HIV_cap256-119-012924_VR-Chain 1972 9614, 17256, 24898, 32540, 40182, 47824, 55466 anti-HIV_cap256-119-011793_VR-Chain 1973 9615, 17257, 24899, 32541, 40183, 47825, 55467 anti-HIV_cap256-119-011413_VR-Chain 1974 9619, 17258, 24900, 32542, 40184, 47826, 55468 anti-HIV_cap256-119-011323_VR-Chain 1975 9617, 17259, 24901, 32543, 40185, 47827, 55469 anti-HIV_cap256-119-011233_VR-Chain 1976 9618, 17260, 24902, 32544, 40186, 47828, 55470 anti-HIV_cap256-119-009038_VR-Chain 1977 9619, 17261, 24903, 32545, 40187, 47829, 55471 anti-HIV_cap256-119-008756_VR-Chain 1978 9620, 17262, 24904, 32546, 40188, 47830, 55472 anti-HIV_cap256-119-008055_VR-Chain 1979 9621, 17263, 24905, 32547, 40189, 47831, 55473 anti-HIV_cap256-119-006949_VR-Chain 1980 9622, 17264, 24906, 32548, 40190, 47832, 55474 anti-HIV_cap256-119-006685_VR-Chain 1981 9623, 17265, 24907, 32549, 40191, 47833, 55475 anti-HIV_cap256-119-006015_VR-Chain 1982 9624, 17266, 24908, 32550, 40192, 47834, 55476 anti-HIV_cap256-119-005841_VR-Chain 1983 9625, 17267, 24909, 32551, 40193, 47835, 55477 anti-HIV_cap256-119-005824_VR-Chain 1984 9626, 17268, 24910, 32552, 40194, 47836, 55478 anti-HIV_cap256-119-005494_VR-Chain 1985 9627, 17269, 24911, 32553, 40195, 47837, 55479 anti-HIV_cap256-119-004949_VR-Chain 1986 9628, 17270, 24912, 32554, 40196, 47838, 55480 anti-HIV_cap256-119-004422_VR-Chain 1987 9629, 17271, 24913, 32555, 40197, 47839, 55481 anti-HIV_cap256-119-003932_VR-Chain 1988 9630, 17272, 24914, 32556, 40198, 47840, 55482 anti-HIV_cap256-119-003577_VR-Chain 1989 9631, 17273, 24915, 32557, 40199, 47841, 55483 anti-HIV_cap256-119-002155_VR-Chain 1990 9632, 17274, 24916, 32558, 40200, 47842, 55484 anti-HIV_cap256-119-002017_VR-Chain 1991 9633, 17275, 24917, 32559, 40201, 47843, 55485 anti-HIV_cap256-119-001312_VR-Chain 1992 9634, 17276, 24918, 32560, 40202, 47844, 55486 anti-HIV_cap256-119-001017_VR-Chain 1993 9635, 17277, 24919, 32561, 40203, 47845, 55487 anti-HIV_cap256-119-000594_VR-Chain 1994 9636, 17278, 24920, 32562, 40204, 47846, 55488 anti-HIV_cap256-059-241099_VR-Chain 1995 9637, 17279, 24921, 32563, 40205, 47847, 55489 anti-HIV_cap256-059-207529_VR-Chain 1996 9638, 17280, 24922, 32564, 40206, 47848, 55490 anti-HIV_cap256-059-205541_VR-Chain 1997 9639, 17281, 24923, 32565, 40207, 47849, 55491 anti-HIV_cap256-059-188439_VR-Chain 1998 9640, 17282, 24924, 32566, 40208, 47850, 55492 anti-HIV_cap256-059-187234_VR-Chain 1999 9641, 17283, 24925, 32567, 40209, 47851, 55493 anti-HIV_cap256-059-187047_VR-Chain 2000 9642, 17284, 24926, 32568, 40210, 47852, 55494 anti-HIV_cap256-059-186068_VR-Chain 2001 9643, 17285, 24927, 32569, 40211, 47853, 55495 anti-HIV_cap256-059-182835_VR-Chain 2002 9644, 17286, 24928, 32570, 40212, 47854, 55496 anti-HIV_cap256-059-176659_VR-Chain 2003 9645, 17287, 24929, 32571, 40213, 47855, 55497 anti-HIV_cap256-059-172956_VR-Chain 2004 9646, 17288, 24930, 32572, 40214, 47856, 55498 anti-HIV_cap256-059-171272_VR-Chain 2005 9647, 17289, 24931, 32573, 40215, 47857, 55499 anti-HIV_cap256-059-168734_VR-Chain 2006 9648, 17290, 24932, 32574, 40216, 47858, 55500 anti-HIV_cap256-059-155838_VR-Chain 2007 9649, 17291, 24933, 32575, 40217, 47859, 55501 anti-HIV_cap256-059-149799_VR-Chain 2008 9650, 17292, 24934, 32576, 40218, 47860, 55502 anti-HIV_cap256-059-148168_VR-Chain 2009 9651, 17293, 24935, 32577, 40219, 47861, 55503 anti-HIV_cap256-059-144685_VR-Chain 2010 9652, 17294, 24936, 32578, 40220, 47862, 55504 anti-HIV_cap256-059-140017_VR-Chain 2011 9653, 17295, 24937, 32579, 40221, 47863, 55505 anti-HIV_cap256-059-137547_VR-Chain 2012 9654, 17296, 24938, 32580, 40222, 47864, 55506 anti-HIV_cap256-059-131908_VR-Chain 2013 9655, 17297, 24939, 32581, 40223, 47865, 55507 anti-HIV_cap256-059-116006_VR-Chain 2014 9656, 17298, 24940, 32582, 40224, 47866, 55508 anti-HIV_cap256-059-115783_VR-Chain 2015 9657, 17299, 24941, 32583, 40225, 47867, 55509 anti-HIV_cap256-059-114609_VR-Chain 2016 9658, 17300, 24942, 32584, 40226, 47868, 55510 anti-HIV_cap256-059-113952_VR-Chain 2017 9659, 17301, 24943, 32585, 40227, 47869, 55511 anti-HIV_cap256-059-113878_VR-Chain 2018 9660, 17302, 24944, 32586, 40228, 47870, 55512 anti-HIV_cap256-059-113622_VR-Chain 2019 9661, 17303, 24945, 32587, 40229, 47871, 55513 anti-HIV_cap256-059-109427_VR-Chain 2020 9662, 17304, 24946, 32588, 40230, 47872, 55514 anti-HIV_cap256-059-109081_VR-Chain 2021 9663, 17305, 24947, 32589, 40231, 47873, 55515 anti-HIV_cap256-059-107590_VR-Chain 2022 9664, 17306, 24948, 32590, 40232, 47874, 55516 anti-HIV_cap256-059-107504_VR-Chain 2023 9665, 17307, 24949, 32591, 40233, 47875, 55517 anti-HIV_cap256-059-099614_VR-Chain 2024 9666, 17308, 24950, 32592, 40234, 47876, 55518 anti-HIV_cap256-059-098972_VR-Chain 2025 9667, 17309, 24951, 32593, 40235, 47877, 55519 anti-HIV_cap256-059-097236_VR-Chain 2026 9668, 17310, 24952, 32594, 40236, 47878, 55520 anti-HIV_cap256-059-091487_VR-Chain 2027 9669, 17311, 24953, 32595, 40237, 47879, 55521 anti-HIV_cap256-059-089812_VR-Chain 2028 9670, 17312, 24954, 32596, 40238, 47880, 55522 anti-HIV_cap256-059-088468_VR-Chain 2029 9671, 17313, 24955, 32597, 40239, 47881, 55523 anti-HIV_cap256-059-088341_VR-Chain 2030 9672, 17314, 24956, 32598, 40240, 47882, 55524 anti-HIV_cap256-059-086533_VR-Chain 2031 9673, 17315, 24957, 32599, 40241, 47883, 55525 anti-HIV_cap256-059-086043_VR-Chain 2032 9674, 17316, 24958, 32600, 40242, 47884, 55526 anti-HIV_cap256-059-084191_VR-Chain 2033 9675, 17317, 24959, 32601, 40243, 47885, 55527 anti-HIV_cap256-059-082135_VR-Chain 2034 9676, 17318, 24960, 32602, 40244, 47886, 55528 anti-HIV_cap256-059-079417_VR-Chain 2035 9677, 17319, 24961, 32603, 40245, 47887, 55529 anti-HIV_cap256-059-076027_VR-Chain 2036 9678, 17320, 24962, 32604, 40246, 47888, 55530 anti-HIV_cap256-059-075082_VR-Chain 2037 9679, 17321, 24963, 32605, 40247, 47889, 55531 anti-HIV_cap256-059-072575_VR-Chain 2038 9680, 17322, 24964, 32606, 40248, 47890, 55532 anti-HIV_cap256-059-071926_VR-Chain 2039 9681, 17323, 24965, 32607, 40249, 47891, 55533 anti-HIV_cap256-059-069638_VR-Chain 2040 9682, 17324, 24966, 32608, 40250, 47892, 55534 anti-HIV_cap256-059-069165_VR-Chain 2041 9683, 17325, 24967, 32609, 40251, 47893, 55535 anti-HIV_cap256-059-068956_VR-Chain 2042 9684, 17326, 24968, 32610, 40252, 47894, 55536 anti-HIV_cap256-059-068876_VR-Chain 2043 9685, 17327, 24969, 32611, 40253, 47895, 55537 anti-HIV_cap256-059-067733_VR-Chain 2044 9686, 17328, 24970, 32612, 40254, 47896, 55538 anti-HIV_cap256-059-067450_VR-Chain 2045 9687, 17329, 24971, 32613, 40255, 47897, 55539 anti-HIV_cap256-059-065694_VR-Chain 2046 9688, 17330, 24972, 32614, 40256, 47898, 55540 anti-HIV_cap256-059-065109_VR-Chain 2047 9689, 17331, 24973, 32615, 40257, 47899, 55541 anti-HIV_cap256-059-065060_VR-Chain 2048 9690, 17332, 24974, 32616, 40258, 47900, 55542 anti-HIV_cap256-059-064001_VR-Chain 2049 9691, 17333, 24975, 32617, 40256, 47901, 55543 anti-HIV_cap256-059-063270_VR-Chain 2050 9692, 17334, 24976, 32618, 40260, 47902, 55544 anti-HIV_cap256-059-061357_VR-Chain 2051 9693, 17335, 24977, 32619, 40261, 47903, 55545 anti-HIV_cap256-059-059834_VR-Chain 2052 9694, 17336, 24978, 32620, 40262, 47904, 55546 anti-HIV_cap256-059-059313_VR-Chain 2053 9695, 17337, 24979, 32621, 40263, 47905, 55547 anti-HIV_cap256-059-057130_VR-Chain 2054 9696, 17338, 24980, 32622, 40264, 47906, 55548 anti-HIV_cap256-059-050520_VR-Chain 2055 9697, 17339, 24981, 32623, 40265, 47907, 55549 anti-HIV_cap256-059-049839_VR-Chain 2056 9698, 17340, 24982, 32624, 40266, 47908, 55550 anti-HIV_cap256-059-048503_VR-Chain 2057 9699, 17341, 24983, 32625, 40267, 47909, 55551 anti-HIV_cap256-059-045516_VR-Chain 2058 9700, 17342, 24984, 32626, 40268, 47910, 55552 anti-HIV_cap256-059-044188_VR-Chain 2059 9701, 17343, 24985, 32627, 40269, 47911, 55553 anti-HIV_cap256-059-044105_VR-Chain 2060 9702, 17344, 24986, 32628, 40270, 47912, 55554 anti-HIV_cap256-059-042100_VR-Chain 2061 9703, 17345, 24987, 32629, 40271, 47913, 55555 anti-HIV_cap256-059-040742_VR-Chain 2062 9704, 17346, 24988, 32630, 40272, 47914, 55556 anti-HIV_cap256-059-040554_VR-Chain 2063 9705, 17347, 24989, 32631, 40273, 47915, 55557 anti-HIV_cap256-059-039660_VR-Chain 2064 9706, 17348, 24990, 32632, 40274, 47916, 55558 anti-HIV_cap256-059-039298_VR-Chain 2065 9707, 17349, 24991, 32633, 40275, 47917, 55559 anti-HIV_cap256-059-037873_VR-Chain 2066 9708, 17350, 24992, 32634, 40276, 47918, 55560 anti-HIV_cap256-059-037633_VR-Chain 2067 9709, 17351, 24993, 32635, 40277, 47919, 55561 anti-HIV_cap256-059-036817_VR-Chain 2068 9710, 17352, 24994, 32636, 40278, 47920, 55562 anti-HIV_cap256-059-032787_VR-Chain 2069 9711, 17353, 24995, 32637, 40279, 47921, 55563 anti-HIV_cap256-059-032427_VR-Chain 2070 9712, 17354, 24996, 32638, 40280, 47922, 55564 anti-HIV_cap256-059-029390_VR-Chain 2071 9713, 17355, 24997, 32639, 40281, 47923, 55565 anti-HIV_cap256-059-027877_VR-Chain 2072 9714, 17356, 24998, 32640, 40282, 47924, 55566 anti-HIV_cap256-059-026640_VR-Chain 2073 9715, 17357, 24999, 32641, 40283, 47925, 55567 anti-HIV_cap256-059-026017_VR-Chain 2074 9716, 17358, 25000, 32642, 40284, 47926, 55568 anti-HIV_cap256-059-024100_VR-Chain 2075 9717, 17359, 25001, 32643, 40285, 47927, 55569 anti-HIV_cap256-059-023966_VR-Chain 2076 9718, 17360, 25002, 32644, 40286, 47928, 55570 anti-HIV_cap256-059-020534_VR-Chain 2077 9719, 17361, 25003, 32645, 40287, 47929, 55571 anti-HIV_cap256-059-019513_VR-Chain 2078 9720, 17362, 25004, 32646, 40288, 47930, 55572 anti-HIV_cap256-059-012963_VR-Chain 2079 9721, 17363, 25005, 32647, 40289, 47931, 55573 anti-HIV_cap256-059-010396_VR-Chain 2080 9722, 17364, 25006, 32648, 40290, 47932, 55574 anti-HIV_cap256-059-008136_VR-Chain 2081 9723, 17365, 25007, 32649, 40291, 47933, 55575 anti-HIV_cap256-059-006147_VR-Chain 2082 9724, 17366, 25008, 32650, 40292, 47934, 55576 anti-HIV_cap256-059-005081_VR-Chain 2083 9725, 17367, 25009, 32651, 40293, 47935, 55577 anti-HIV_cap256-059-005006_VR-Chain 2084 9726, 17368, 25010, 32652, 40294, 47936, 55578 anti-HIV_cap256-059-004451_VR-Chain 2085 9727, 17369, 25011, 32653, 40295, 47937, 55579 anti-HIV_cap256-059-003571_VR-Chain 2086 9728, 17370, 25012, 32654, 40296, 47938, 55580 anti-HIV_cap256-059-003449_VR-Chain 2087 9729, 17371, 25013, 32655, 40297, 47939, 55581 anti-HIV_cap256-059-002712_VR-Chain 2088 9730, 17372, 25014, 32656, 40298, 47940, 55582 anti-HIV_cap256-059-001573_VR-Chain 2089 9731, 17373, 25015, 32657, 40299, 47941, 55583 anti-HIV_cap256-059-001379_VR-Chain 2090 9732, 17374, 25016, 32658, 40300, 47942, 55584 anti-HIV_cap256-059-001029_VR-Chain 2091 9733, 17375, 25017, 32659, 40301, 47943, 55585 anti-HIV_cap256-048-165087_VR-Chain 2092 9734, 17376, 25018, 32660, 40302, 47944, 55586 anti-HIV_cap256-048-158861_VR-Chain 2093 9735, 17377, 25019, 32661, 40303, 47945, 55587 anti-HIV_cap256-048-158280_VR-Chain 2094 9736, 17378, 25020, 32662, 40304, 47946, 55588 anti-HIV_cap256-048-157928_VR-Chain 2095 9737, 17379, 25021, 32663, 40305, 47947, 55589 anti-HIV_cap256-048-157056_VR-Chain 2096 9738, 17380, 25022, 32664, 40306, 47948, 55590 anti-HIV_cap256-048-156422_VR-Chain 2097 9739, 17381, 25023, 32665, 40307, 47949, 55591 anti-HIV_cap256-048-152863_VR-Chain 2098 9740, 17382, 25024, 32666, 40308, 47950, 55592 anti-HIV_cap256-048-152770_VR-Chain 2099 9741, 17383, 25025, 32667, 40309, 47951, 55593 anti-HIV_cap256-048-150027_VR-Chain 2100 9742, 17384, 25026, 32668, 40310, 47952, 55594 anti-HIV_cap256-048-148246_VR-Chain 2101 9743, 17385, 25027, 32669, 40311, 47953, 55595 anti-HIV_cap256-048-147428_VR-Chain 2102 9744, 17386, 25028, 32670, 40312, 47954, 55596 anti-HIV_cap256-048-146603_VR-Chain 2103 9745, 17387, 25029, 32671, 40313, 47955, 55597 anti-HIV_cap256-048-145735_VR-Chain 2104 9746, 17388, 25030, 32672, 40314, 47956, 55598 anti-HIV_cap256-048-145116_VR-Chain 2105 9747, 17389, 25031, 32673, 40315, 47957, 55599 anti-HIV_cap256-048-144077_VR-Chain 2106 9748, 17390, 25032, 32674, 40316, 47958, 55600 anti-HIV_cap256-048-142876_VR-Chain 2107 9749, 17391, 25033, 32675, 40317, 47959, 55601 anti-HIV_cap256-048-140582_VR-Chain 2108 9750, 17392, 25034, 32676, 40318, 47960, 55602 anti-HIV_cap256-048-139355_VR-Chain 2109 9751, 17393, 25035, 32677, 40319, 47961, 55603 anti-HIV_cap256-048-139151_VR-Chain 2110 9752, 17394, 25036, 32678, 40320, 47962, 55604 anti-HIV_cap256-048-137672_VR-Chain 2111 9753, 17395, 25037, 32679, 40321, 47963, 55605 anti-HIV_cap256-048-137506_VR-Chain 2112 9754, 17396, 25038, 32680, 40322, 47964, 55606 anti-HIV_cap256-048-137270_VR-Chain 2113 9755, 17397, 25039, 32681, 40323, 47965, 55607 anti-HIV_cap256-048-135447_VR-Chain 2114 9756, 17398, 25040, 32682, 40324, 47966, 55608 anti-HIV_cap256-048-131966_VR-Chain 2115 9757, 17399, 25041, 32683, 40325, 47967, 55609 anti-HIV_cap256-048-131008_VR-Chain 2116 9758, 17400, 25042, 32684, 40326, 47968, 55610 anti-HIV_cap256-048-129369_VR-Chain 2117 9759, 17401, 25043, 32685, 40327, 47969, 55611 anti-HIV_cap256-048-128476_VR-Chain 2118 9760, 17402, 25044, 32686, 40328, 47970, 55612 anti-HIV_cap256-048-128270_VR-Chain 2119 9761, 17403, 25045, 32687, 40329, 47971, 55613 anti-HIV_cap256-048-126220_VR-Chain 2120 9762, 17404, 25046, 32688, 40330, 47972, 55614 anti-HIV_cap256-048-125713_VR-Chain 2121 9763, 17405, 25047, 32689, 40331, 47973, 55615 anti-HIV_cap256-048-123934_VR-Chain 2122 9764, 17406, 25048, 32690, 40332, 47974, 55616 anti-HIV_cap256-048-122673_VR-Chain 2123 9765, 17407, 25049, 32691, 40333, 47975, 55617 anti-HIV_cap256-048-122208_VR-Chain 2124 9796, 17408, 25050, 32692, 40334, 47976, 55618 anti-HIV_cap256-048-121552_VR-Chain 2125 9767, 17409, 25051, 32693, 40335, 47977, 55619 anti-HIV_cap256-048-120643_VR-Chain 2126 9768, 17410, 25052, 32694, 40336, 47978, 55620 anti-HIV_cap256-048-118458_VR-Chain 2127 9769, 17411, 25053, 32695, 40337, 47979, 55621 anti-HIV_cap256-048-118112_VR-Chain 2128 9770, 17412, 25054, 32696, 40338, 47980, 55622 anti-HIV_cap256-048-116469_VR-Chain 2129 9771, 17413, 25055, 32697, 40339, 47981, 55623 anti-HIV_cap256-048-113917_VR-Chain 2130 9772, 17414, 25056, 32698, 40340, 47982, 55624 anti-HIV_cap256-048-112368_VR-Chain 2131 9773, 17415, 25057, 32699, 40341, 47983, 55625 anti-HIV_cap256-048-112047_VR-Chain 2132 9774, 17416, 25058, 32700, 40342, 47984, 55626 anti-HIV_cap256-048-112029_VR-Chain 2133 9775, 17417, 25059, 32701, 40343, 47985, 55627 anti-HIV_cap256-048-110957_VR-Chain 2134 9776, 17418, 25060, 32702, 40344, 47986, 55628 anti-HIV_cap256-048-110526_VR-Chain 2135 9777, 17419, 25061, 32703, 40345, 47987, 55629 anti-HIV_cap256-048-109336_VR-Chain 2136 9778, 17420, 25062, 32704, 40346, 47988, 55630 anti-HIV_cap256-048-108152_VR-Chain 2137 9779, 17421, 25063, 32705, 40347, 47989, 55631 anti-HIV_cap256-048-107799_VR-Chain 2138 9780, 17422, 25064, 32706, 40348, 47990, 55632 anti-HIV_cap256-048-107384_VR-Chain 2139 9781, 17423, 25065, 32707, 40349, 47991, 55633 anti-HIV_cap256-048-106530_VR-Chain 2140 9782, 17424, 25066, 32708, 40350, 47992, 55634 anti-HIV_cap256-048-106464_VR-Chain 2141 9783, 17425, 25067, 32709, 40351, 47993, 55635 anti-HIV_cap256-048-106411_VR-Chain 2142 9784, 17426, 25068, 32710, 40352, 47994, 55636 anti-HIV_cap256-048-106306_VR-Chain 2143 9785, 17427, 25069, 32711, 40353, 47995, 55637 anti-HIV_cap256-048-104496_VR-Chain 2144 9786, 17428, 25070, 32712, 40354, 47996, 55638 anti-HIV_cap256-048-103074_VR-Chain 2145 9787, 17429, 25071, 32713, 40355, 47997, 55639 anti-HIV_cap256-048-100832_VR-Chain 2146 9788, 17430, 25072, 32714, 40356, 47998, 55640 anti-HIV_cap256-048-100188_VR-Chain 2147 9789, 17431, 25073, 32715, 40357, 47999, 55641 anti-HIV_cap256-048-099645_VR-Chain 2148 9790, 17432, 25074, 32716, 40358, 48000, 55642 anti-HIV_cap256-048-098137_VR-Chain 2149 9791, 17433, 25075, 32717, 40359, 48001, 55643 anti-HIV_cap256-048-097878_VR-Chain 2150 9792, 17434, 25076, 32718, 40360, 48002, 55644 anti-HIV_cap256-048-097510_VR-Chain 2151 9793, 17435, 25077, 32719, 40361, 48003, 55645 anti-HIV_cap256-048-097313_VR-Chain 2152 9794, 17436, 25078, 32720, 40362, 48004, 55646 anti-HIV_cap256-048-096626_VR-Chain 2153 9795, 17437, 25079, 32721, 40363, 48005, 55647 anti-HIV_cap256-048-096483_VR-Chain 2154 9796, 17438, 25080, 32722, 40364, 48006, 55648 anti-HIV_cap256-048-095691_VR-Chain 2155 9797, 17439, 25081, 32723, 40365, 48007, 55649 anti-HIV_cap256-048-095525_VR-Chain 2156 9798, 17440, 25082, 32724, 40366, 48008, 55650 anti-HIV_cap256-048-094783_VR-Chain 2157 9799, 17441, 25083, 32725, 40367, 48009, 55651 anti-HIV_cap256-048-094356_VR-Chain 2158 9800, 17442, 25084, 32726, 40368, 48010, 55652 anti-HIV_cap256-048-090756_VR-Chain 2159 9801, 17443, 25085, 32727, 40369, 48011, 55653 anti-HIV_cap256-048-089065_VR-Chain 2160 9802, 17444, 25086, 32728, 40370, 48012, 55654 anti-HIV_cap256-048-084986_VR-Chain 2161 9803, 17445, 25087, 32729, 40371, 48013, 55655 anti-HIV_cap256-048-083355_VR-Chain 2162 9804, 17446, 25088, 32730, 40372, 48014, 55656 anti-HIV_cap256-048-082462_VR-Chain 2163 9805, 17447, 25089, 32731, 40373, 48015, 55657 anti-HIV_cap256-048-082246_VR-Chain 2164 9806, 17448, 25090, 32732, 40374, 48016, 55658 anti-HIV_cap256-048-080752_VR-Chain 2165 9807, 17449, 25091, 32733, 40375, 48017, 55659 anti-HIV_cap256-048-078409_VR-Chain 2166 9808, 17450, 25092, 32734, 40376, 48018, 55660 anti-HIV_cap256-048-078273_VR-Chain 2167 9809, 17451, 25093, 32735, 40377, 48019, 55661 anti-HIV_cap256-048-078062_VR-Chain 2168 9810, 17452, 25094, 32736, 40378, 48020, 55662 anti-HIV_cap256-048-077798_VR-Chain 2169 9811, 17453, 25095, 32737, 40379, 48021, 55663 anti-HIV_cap256-048-073853_VR-Chain 2170 9812, 17454, 25096, 32738, 40380, 48022, 55664 anti-HIV_cap256-048-071661_VR-Chain 2171 9813, 17455, 25097, 32739, 40381, 48023, 55665 anti-HIV_cap256-048-071360_VR-Chain 2172 9814, 17456, 25098, 32740, 40382, 48024, 55666 anti-HIV_cap256-048-070955_VR-Chain 2173 9815, 17457, 25099, 32741, 40383, 48025, 55667 anti-HIV_cap256-048-070061_VR-Chain 2174 9816, 17458, 25100, 32742, 40384, 48026, 55668 anti-HIV_cap256-048-069669_VR-Chain 2175 9817, 17459, 25101, 32743, 40385, 48027, 55669 anti-HIV_cap256-048-069205_VR-Chain 2176 9818, 17460, 25102, 32744, 40386, 48028, 55670 anti-HIV_cap256-048-068882_VR-Chain 2177 9819, 17461, 25103, 32745, 40387, 48029, 55671 anti-HIV_cap256-048-067764_VR-Chain 2178 9820, 17462, 25104, 32746, 40388, 48030, 55672 anti-HIV_cap256-048-066845_VR-Chain 2179 9821, 17463, 25105, 32747, 40389, 48031, 55673 anti-HIV_cap256-048-065226_VR-Chain 2180 9822, 17464, 25106, 32748, 40390, 48032, 55674 anti-HIV_cap256-048-063717_VR-Chain 2181 9823, 17465, 25107, 32749, 40391, 48033, 55675 anti-HIV_cap256-048-063150_VR-Chain 2182 9824, 17466, 25108, 32750, 40392, 48034, 55676 anti-HIV_cap256-048-062431_VR-Chain 2183 9825, 17467, 25109, 32751, 40393, 48035, 55677 anti-HIV_cap256-048-060745_VR-Chain 2184 9826, 17468, 25110, 32752, 40394, 48036, 55678 anti-HIV_cap256-048-060420_VR-Chain 2185 9827, 17469, 25111, 32753, 40395, 48037, 55679 anti-HIV_cap256-048-060014_VR-Chain 2186 9828, 17470, 25112, 32754, 40396, 48038, 55680 anti-HIV_cap256-048-059747_VR-Chain 2187 9829, 17471, 25113, 32755, 40397, 48039, 55681 anti-HIV_cap256-048-058393_VR-Chain 2188 9830, 17472, 25114, 32756, 40398, 48040, 55682 anti-HIV_cap256-048-058159_VR-Chain 2189 9831, 17473, 25115, 32757, 40399, 48041, 55683 anti-HIV_cap256-048-057127_VR-Chain 2190 9832, 17474, 25116, 32758, 40400, 48042, 55684 anti-HIV_cap256-048-056251_VR-Chain 2191 9833, 17475, 25117, 32759, 40401, 48043, 55685 anti-HIV_cap256-048-055421_VR-Chain 2192 9834, 17476, 25118, 32760, 40402, 48044, 55686 anti-HIV_cap256-048-054989_VR-Chain 2193 9835, 17477, 25119, 32761, 40403, 48045, 55687 anti-HIV_cap256-048-054759_VR-Chain 2194 9836, 17478, 25120, 32762, 40404, 48046, 55688 anti-HIV_cap256-048-052573_VR-Chain 2195 9837, 17479, 25121, 32763, 40405, 48047, 55689 anti-HIV_cap256-048-051477_VR-Chain 2196 9838, 17480, 25122, 32764, 40406, 48048, 55690 anti-HIV_cap256-048-051299_VR-Chain 2197 9839, 17481, 25123, 32765, 40407, 48049, 55691 anti-HIV_cap256-048-050815_VR-Chain 2198 9840, 17482, 25124, 32766, 40408, 48050, 55692 anti-HIV_cap256-048-049884_VR-Chain 2199 9841, 17483, 25125, 32767, 40409, 48051, 55693 anti-HIV_cap256-048-049170_VR-Chain 2200 9842, 17484, 25126, 32768, 40410, 48052, 55694 anti-HIV_cap256-048-048531_VR-Chain 2201 9843, 17485, 25127, 32769, 40411, 48053, 55695 anti-HIV_cap256-048-048259_VR-Chain 2202 9844, 17486, 25128, 32770, 40412, 48054, 55696 anti-HIV_cap256-048-047313_VR-Chain 2203 9845, 17487, 25129, 32771, 40413, 48055, 55697 anti-HIV_cap256-048-046596_VR-Chain 2204 9846, 17488, 25130, 32772, 40414, 48056, 55698 anti-HIV_cap256-048-044781_VR-Chain 2205 9847, 17489, 25131, 32773, 40415, 48057, 55699 anti-HIV_cap256-048-042599_VR-Chain 2206 9848, 17490, 25132, 32774, 40416, 48058, 55700 anti-HIV_cap256-048-041276_VR-Chain 2207 9849, 17491, 25133, 32775, 40417, 48059, 55701 anti-HIV_cap256-048-040200_VR-Chain 2208 9850, 17492, 25134, 32776, 40418, 48060, 55702 anti-HIV_cap256-048-039061_VR-Chain 2209 9851, 17493, 25135, 32777, 40419, 48061, 55703 anti-HIV_cap256-048-038515_VR-Chain 2210 9852, 17494, 25136, 32778, 40420, 48062, 55704 anti-HIV_cap256-048-038255_VR-Chain 2211 9853, 17495, 25137, 32779, 40421, 48063, 55705 anti-HIV_cap256-048-038177_VR-Chain 2212 9854, 17496, 25138, 32780, 40422, 48064, 55706 anti-HIV_cap256-048-035513_VR-Chain 2213 9855, 17497, 25139, 32781, 40423, 48065, 55707 anti-HIV_cap256-048-034112_VR-Chain 2214 9856, 17498, 25140, 32782, 40424, 48066, 55708 anti-HIV_cap256-048-033983_VR-Chain 2215 9857, 17499, 25141, 32783, 40425, 48067, 55709 anti-HIV_cap256-048-032688_VR-Chain 2216 9858, 17500, 25142, 32784, 40426, 48068, 55710 anti-HIV_cap256-048-031092_VR-Chain 2217 9859, 17501, 25143, 32785, 40427, 48069, 55711 anti-HIV_cap256-048-030464_VR-Chain 2218 9860, 17502, 25144, 32786, 40428, 48070, 55712 anti-HIV_cap256-048-030289_VR-Chain 2219 9861, 17503, 25145, 32787, 40429, 48071, 55713 anti-HIV_cap256-048-030261_VR-Chain 2220 9862, 17504, 25146, 32788, 40430, 48072, 55714 anti-HIV_cap256-048-029362_VR-Chain 2221 9863, 17505, 25147, 32789, 40431, 48073, 55715 anti-HIV_cap256-048-027638_VR-Chain 2222 9864, 17506, 25148, 32790, 40432, 48074, 55716 anti-HIV_cap256-048-027613_VR-Chain 2223 9865, 17507, 25149, 32791, 40433, 48075, 55717 anti-HIV_cap256-048-026627_VR-Chain 2224 9866, 17508, 25150, 32792, 40434, 48076, 55718 anti-HIV_cap256-048-026239_VR-Chain 2225 9867, 17509, 25151, 32793, 40435, 48077, 55719 anti-HIV_cap256-048-025518_VR-Chain 2226 9868, 17510, 25152, 32794, 40436, 48078, 55720 anti-HIV_cap256-048-024854_VR-Chain 2227 9869, 17511, 25153, 32795, 40437, 48079, 55721 anti-HIV_cap256-048-024537_VR-Chain 2228 9870, 17512, 25154, 32796, 40438, 48080, 55722 anti-HIV_cap256-048-021781_VR-Chain 2229 9871, 17513, 25155, 32797, 40439, 48081, 55723 anti-HIV_cap256-048-021758_VR-Chain 2230 9872, 17514, 25156, 32798, 40440, 48082, 55724 anti-HIV_cap256-048-020988_VR-Chain 2231 9873, 17515, 25157, 32799, 40441, 48083, 55725 anti-HIV_cap256-048-020663_VR-Chain 2232 9874, 17516, 25158, 32800, 40442, 48084, 55726 anti-HIV_cap256-048-020590_VR-Chain 2233 9875, 17517, 25159, 32801, 40443, 48085, 55727 anti-HIV_cap256-048-019765_VR-Chain 2234 9876, 17518, 25160, 32802, 40444, 48086, 55728 anti-HIV_cap256-048-019254_VR-Chain 2235 9877, 17519, 25161, 32803, 40445, 48087, 55729 anti-HIV_cap256-048-018073_VR-Chain 2236 9878, 17520, 25162, 32804, 40446, 48088, 55730 anti-HIV_cap256-048-016775_VR-Chain 2237 9879, 17521, 25163, 32805, 40447, 48089, 55731 anti-HIV_cap256-048-016069_VR-Chain 2238 9880, 17522, 25164, 32806, 40448, 48090, 55732 anti-HIV_cap256-048-015867_VR-Chain 2239 9881, 17523, 25165, 32807, 40449, 48091, 55733 anti-HIV_cap256-048-015673_VR-Chain 2240 9882, 17524, 25166, 32808, 40450, 48092, 55734 anti-HIV_cap256-048-015156_VR-Chain 2241 9883, 17525, 25167, 32809, 40451, 48093, 55735 anti-HIV_cap256-048-014521_VR-Chain 2242 9884, 17526, 25168, 32810, 40452, 48094, 55736 anti-HIV_cap256-048-014475_VR-Chain 2243 9885, 17527, 25169, 32811, 40453, 48095, 55737 anti-HIV_cap256-048-013798_VR-Chain 2244 9886, 17528, 25170, 32812, 40454, 48096, 55738 anti-HIV_cap256-048-013271_VR-Chain 2245 9887, 17529, 25171, 32813, 40455, 48097, 55739 anti-HIV_cap256-048-013180_VR-Chain 2246 9888, 17530, 25172, 32814, 40456, 48098, 55740 anti-HIV_cap256-048-012148_VR-Chain 2247 9889, 17531, 25173, 32815, 40457, 48099, 55741 anti-HIV_cap256-048-011870_VR-Chain 2248 9890, 17532, 25174, 32816, 40458, 48100, 55742 anti-HIV_cap256-048-011530_VR-Chain 2249 9891, 17533, 25175, 32817, 40459, 48101, 55743 anti-HIV_cap256-048-010968_VR-Chain 2250 9892, 17534, 25176, 32818, 40460, 48102, 55744 anti-HIV_cap256-048-010224_VR-Chain 2251 9893, 17535, 25177, 32819, 40461, 48103, 55745 anti-HIV_cap256-048-009749_VR-Chain 2252 9894, 17536, 25178, 32820, 40462, 48104, 55746 anti-HIV_cap256-048-009623_VR-Chain 2253 9895, 17537, 25179, 32821, 40463, 48105, 55747 anti-HIV_cap256-048-008234_VR-Chain 2254 9896, 17538, 25180, 32822, 40464, 48106, 55748 anti-HIV_cap256-048-008149_VR-Chain 2255 9897, 17539, 25181, 32823, 40465, 48107, 55749 anti-HIV_cap256-048-007301_VR-Chain 2256 9898, 17540, 25182, 32824, 40466, 48108, 55750 anti-HIV_cap256-048-007174_VR-Chain 2257 9899, 17541, 25183, 32825, 40467, 48109, 55751 anti-HIV_cap256-048-007079_VR-Chain 2258 9900, 17542, 25184, 32826, 40468, 48110, 55752 anti-HIV_cap256-048-007033_VR-Chain 2259 9901, 17543, 25185, 32827, 40469, 48111, 55753 anti-HIV_cap256-048-006128_VR-Chain 2260 9902, 17544, 25186, 32828, 40470, 48112, 55754 anti-HIV_cap256-048-005999_VR-Chain 2261 9903, 17545, 25187, 32829, 40471, 48113, 55755 anti-HIV_cap256-048-005394_VR-Chain 2262 9904, 17546, 25188, 32830, 40472, 48114, 55756 anti-HIV_cap256-048-004226_VR-Chain 2263 9905, 17547, 25189, 32831, 40473, 48115, 55757 anti-HIV_cap256-048-004097_VR-Chain 2264 9906, 17548, 25190, 32832, 40474, 48116, 55758 anti-HIV_cap256-048-003289_VR-Chain 2265 9907, 17549, 25191, 32833, 40475, 48117, 55759 anti-HIV_cap256-048-002601_VR-Chain 2266 9908, 17550, 25192, 32834, 40476, 48118, 55760 anti-HIV_cap256-048-002129_VR-Chain 2267 9909, 17551, 25193, 32835, 40477, 48119, 55761 anti-HIV_cap256-048-001875_VR-Chain 2268 9910, 17552, 25194, 32836, 40478, 48120, 55762 anti-HIV_cap256-048-001302_VR-Chain 2269 9911, 17553, 25195, 32837, 40479, 48121, 55763 anti-HIV_cap256-048-001203_VR-Chain 2270 9912, 17554, 25196, 32838, 40480, 48122, 55764 anti-HIV_cap256-048-000383_VR-Chain 2271 9913, 17555, 25197, 32839, 40481, 48123, 55765 anti-HIV_cap256-038-261791_VR-Chain 2272 9914, 17556, 25198, 32840, 40482, 48124, 55766 anti-HIV_cap256-038-241540_VR-Chain 2273 9915, 17557, 25199, 32841, 40483, 48125, 55767 anti-HIV_cap256-038-235677_VR-Chain 2274 9916, 17558, 25200, 32842, 40484, 48126, 55768 anti-HIV_cap256-038-234314_VR-Chain 2275 9917, 17559, 25201, 32843, 40485, 48127, 55769 anti-HIV_cap256-038-234273_VR-Chain 2276 9918, 17560, 25202, 32844, 40486, 48128, 55770 anti-HIV_cap256-038-223164_VR-Chain 2277 9919, 17561, 25203, 32845, 40487, 48129, 55771 anti-HIV_cap256-038-220289_VR-Chain 2278 9920, 17562, 25204, 32846, 40488, 48130, 55772 anti-HIV_cap256-038-220020_VR-Chain 2279 9921, 17563, 25205, 32847, 40489, 48131, 55773 anti-HIV_cap256-038-216853_VR-Chain 2280 9922, 17564, 25206, 32848, 40490, 48132, 55774 anti-HIV_cap256-038-213466_VR-Chain 2281 9923, 17565, 25207, 32849, 40491, 48133, 55775 anti-HIV_cap256-038-213212_VR-Chain 2282 9924, 17566, 25208, 32850, 40492, 48134, 55776 anti-HIV_cap256-038-213120_VR-Chain 2283 9925, 17567, 25209, 32851, 40493, 48135, 55777 anti-HIV_cap256-038-212592_VR-Chain 2284 9926, 17568, 25210, 32852, 40494, 48136, 55778 anti-HIV_cap256-038-211790_VR-Chain 2285 9927, 17569, 25211, 32853, 40495, 48137, 55779 anti-HIV_cap256-038-209916_VR-Chain 2286 9928, 17570, 25212, 32854, 40496, 48138, 55780 anti-HIV_cap256-038-207938_VR-Chain 2287 9929, 17571, 25213, 32855, 40497, 48139, 55781 anti-HIV_cap256-038-202245_VR-Chain 2288 9930, 17572, 25214, 32856, 40498, 48140, 55782 anti-HIV_cap256-038-197721_VR-Chain 2289 9931, 17573, 25215, 32857, 40499, 48141, 55783 anti-HIV_cap256-038-196679_VR-Chain 2290 9932, 17574, 25216, 32858, 40500, 48142, 55784 anti-HIV_cap256-038-196118_VR-Chain 2291 9933, 17575, 25217, 32859, 40501, 48143, 55785 anti-HIV_cap256-038-195382_VR-Chain 2292 9934, 17576, 25218, 32860, 40502, 48144, 55786 anti-HIV_cap256-038-180001_VR-Chain 2293 9935, 17577, 25219, 32861, 40503, 48145, 55787 anti-HIV_cap256-038-178021_VR-Chain 2294 9936, 17578, 25220, 32862, 40504, 48146, 55788 anti-HIV_cap256-038-177104_VR-Chain 2295 9937, 17579, 25221, 32863, 40505, 48147, 55789 anti-HIV_cap256-038-171261_VR-Chain 2296 9938, 17580, 25222, 32864, 40506, 48148, 55790 anti-HIV_cap256-038-169090_VR-Chain 2297 9939, 17581, 25223, 32865, 40507, 48149, 55791 anti-HIV_cap256-038-168705_VR-Chain 2298 9940, 17582, 25224, 32866, 40508, 48150, 55792 anti-HIV_cap256-038-167685_VR-Chain 2299 9941, 17583, 25225, 32867, 40509, 48151, 55793 anti-HIV_cap256-038-158775_VR-Chain 2300 9942, 17584, 25226, 32868, 40510, 48152, 55794 anti-HIV_cap256-038-157318_VR-Chain 2301 9943, 17585, 25227, 32869, 40511, 48153, 55795 anti-HIV_cap256-038-153058_VR-Chain 2302 9944, 17586, 25228, 32870, 40512, 48154, 55796 anti-HIV_cap256-038-150027_VR-Chain 2303 9945, 17587, 25229, 32871, 40513, 48155, 55797 anti-HIV_cap256-038-146372_VR-Chain 2304 9946, 17588, 25230, 32872, 40514, 48156, 55798 anti-HIV_cap256-038-141868_VR-Chain 2305 9947, 17589, 25231, 32873, 40515, 48157, 55799 anti-HIV_cap256-038-141616_VR-Chain 2306 9948, 17590, 25232, 32874, 40516, 48158, 55800 anti-HIV_cap256-038-127989_VR-Chain 2307 9949, 17591, 25233, 32875, 40517, 48159, 55801 anti-HIV_cap256-038-118109_VR-Chain 2308 9950, 17592, 25234, 32876, 40518, 48160, 55802 anti-HIV_cap256-038-112226_VR-Chain 2309 9951, 17593, 25235, 32877, 40519, 48161, 55803 anti-HIV_cap256-038-105918_VR-Chain 2310 9952, 17594, 25236, 32878, 40520, 48162, 55804 anti-HIV_cap256-038-104487_VR-Chain 2311 9953, 17595, 25237, 32879, 40521, 48163, 55805 anti-HIV_cap256-038-102308_VR-Chain 2312 9954, 17596, 25238, 32880, 40522, 48164, 55806 anti-HIV_cap256-038-091115_VR-Chain 2313 9955, 17597, 25239, 32881, 40523, 48165, 55807 anti-HIV_cap256-038-090262_VR-Chain 2314 9956, 17598, 25240, 32882, 40524, 48166, 55808 anti-HIV_cap256-038-083260_VR-Chain 2315 9957, 17599, 25241, 32883, 40525, 48167, 55809 anti-HIV_cap256-038-080981_VR-Chain 2316 9958, 17600, 25242, 32884, 40526, 48168, 55810 anti-HIV_cap256-038-080873_VR-Chain 2317 9959, 17601, 25243, 32885, 40527, 48169, 55811 anti-HIV_cap256-038-074413_VR-Chain 2318 9960, 17602, 25244, 32886, 40528, 48170, 55812 anti-HIV_cap256-038-073153_VR-Chain 2319 9961, 17603, 25245, 32887, 40529, 48171, 55813 anti-HIV_cap256-038-064227_VR-Chain 2320 9962, 17604, 25246, 32888, 40530, 48172, 55814 anti-HIV_cap256-038-061640_VR-Chain 2321 9963, 17605, 25247, 32889, 40531, 48173, 55815 anti-HIV_cap256-038-059482_VR-Chain 2322 9964, 17606, 25248, 32890, 40532, 48174, 55816 anti-HIV_cap256-038-054000_VR-Chain 2323 9965, 17607, 25249, 32891, 40533, 48175, 55817 anti-HIV_cap256-038-050554_VR-Chain 2324 9966, 17608, 25250, 32892, 40534, 48176, 55818 anti-HIV_cap256-038-044256_VR-Chain 2325 9967, 17609, 25251, 32893, 40535, 48177, 55819 anti-HIV_cap256-038-040944_VR-Chain 2326 9968, 17610, 25252, 32894, 40536, 48178, 55820 anti-HIV_cap256-038-040090_VR-Chain 2327 9969, 17611, 25253, 32895, 40537, 48179, 55821 anti-HIV_cap256-038-032874_VR-Chain 2328 9970, 17612, 25254, 32896, 40538, 48180, 55822 anti-HIV_cap256-038-025899_VR-Chain 2329 9971, 17613, 25255, 32897, 40539, 48181, 55823 anti-HIV_cap256-038-024581_VR-Chain 2330 9972, 17614, 25256, 32898, 40540, 48182, 55824 anti-HIV_cap256-038-013345_VR-Chain 2331 9973, 17615, 25257, 32899, 40541, 48183, 55825 anti-HIV_cap256-038-011559_VR-Chain 2332 9974, 17616, 25258, 32900, 40542, 48184, 55826 anti-HIV_cap256-038-009634_VR-Chain 2333 9975, 17617, 25259, 32901, 40543, 48185, 55827 anti-HIV_cap256-038-006730_VR-Chain 2334 9976, 17618, 25260, 32902, 40544, 48186, 55828 anti-HIV_cap256-038-004887_VR-Chain 2335 9977, 17619, 25261, 32903, 40545, 48187, 55829 anti-HIV_cap256-038-004840_VR-Chain 2336 9978, 17620, 25262, 32904, 40546, 48188, 55830 anti-HIV_cap256-038-002181_VR-Chain 2337 9979, 17621, 25263, 32905, 40547, 48189, 55831 anti-HIV_cap256-038-001902_VR-Chain 2338 9980, 17622, 25264, 32906, 40548, 48190, 55832 anti-HIV_cap256-038-000976_VR-Chain 2339 9981, 17623, 25265, 32907, 40549, 48191, 55833 anti-HIV_cap256-038-000384_VR-Chain 2340 9982, 17624, 25266, 32908, 40550, 48192, 55834 anti-HIV_206-314431_VR-Chain 2341 9983, 17625, 25267, 32909, 40551, 48193, 55835 anti-HIV_206-247594_VR-Chain 2342 9984, 17626, 25268, 32910, 40552, 48194, 55836 anti-HIV_206-116890_VR-Chain 2343 9985, 17627, 25269, 32911, 40553, 48195, 55837 anti-HIV_206-072383_VR-Chain 2344 9986, 17628, 25270, 32912, 40554, 48196, 55838 anti-HIV_206-037527_VR-Chain 2345 9987, 17629, 25271, 32913, 40555, 48197, 55839 anti-HIV_206-009095_VR-Chain 2346 9988, 17630, 25272, 32914, 40556, 48198, 55840 anti-HIV_176-503620_VR-Chain 2347 9989, 17631, 25273, 32915, 40557, 48199, 55841 anti-HIV_176-478729_VR-Chain 2348 9990, 17632, 25274, 32916, 40558, 48200, 55842 anti-HIV_176-245059_VR-Chain 2349 9991, 17633, 25275, 32917, 40559, 48201, 55843 anti-HIV_176-164413_VR-Chain 2350 9992, 17634, 25276, 32918, 40560, 48202, 55844 anti-HIV_176-094308_VR-Chain 2351 9993, 17635, 25277, 32919, 40561, 48203, 55845 anti-HIV_176-065321_VR-Chain 2352 9994, 17636, 25278, 32920, 40562, 48204, 55846 anti-HIV_119-099719_VR-Chain 2353 9995, 17637, 25279, 32921, 40563, 48205, 55847 anti-HIV_119-099536_VR-Chain 2354 9996, 17638, 25280, 32922, 40564, 48206, 55848 anti-HIV_119-098907_VR-Chain 2355 9997, 17639, 25281, 32923, 40565, 48207, 55849 anti-HIV_119-098555_VR-Chain 2356 9998, 17640, 25282, 32924, 40566, 48208, 55850 anti-HIV_119-097828_VR-Chain 2357 9999, 17641, 25283, 32925, 40567, 48209, 55851 anti-HIV_119-096480_VR-Chain 2358 10000, 17642, 25284, 32926, 40568, 48210, 55852 anti-HIV_119-095664_VR-Chain 2359 10001, 17643, 25285, 32927, 40569, 48211, 55853 anti-HIV_119-095212_VR-Chain 2360 10002, 17644, 25286, 32928, 40570, 48212, 55854 anti-HIV_119-094773_VR-Chain 2361 10003, 17645, 25287, 32929, 40571, 48213, 55855 anti-HIV_119-094508_VR-Chain 2362 10004, 17646, 25288, 32930, 40572, 48214, 55856 anti-HIV_119-093795_VR-Chain 2363 10005, 17647, 25289, 32931, 40573, 48215, 55857 anti-HIV_119-093732_VR-Chain 2364 10006, 17648, 25290, 32932, 40574, 48216, 55858 anti-HIV_119-092903_VR-Chain 2365 10007, 17649, 25291, 32933, 40575, 48217, 55859 anti-HIV_119-092284_VR-Chain 2366 10008, 17650, 25292, 32934, 40579, 48218, 55860 anti-HIV_119-091586_VR-Chain 2367 10009, 17651, 25293, 32935, 40577, 48219, 55861 anti-HIV_119-091023_VR-Chain 2368 10010, 17652, 25294, 32936, 40578, 48220, 55862 anti-HIV_119-090334_VR-Chain 2369 10011, 17653, 25295, 32937, 40579, 48221, 55863 anti-HIV_119-088694_VR-Chain 2370 10012, 17654, 25296, 32938, 40580, 48222, 55864 anti-HIV_119-088499_VR-Chain 2371 10013, 17655, 25297, 32939, 40581, 48223, 55865 anti-HIV_119-088298_VR-Chain 2372 10014, 17656, 25298, 32940, 40582, 48224, 55866 anti-HIV_119-087488_VR-Chain 2373 10015, 17657, 25299, 32941, 40583, 48225, 55867 anti-HIV_119-087423_VR-Chain 2374 10016, 17658, 25300, 32942, 40584, 48226, 55868 anti-HIV_119-087371_VR-Chain 2375 10017, 17659, 25301, 32943, 40585, 48227, 55869 anti-HIV_119-087279_VR-Chain 2376 10018, 17660, 25302, 32944, 40586, 48228, 55870 anti-HIV_119-087146_VR-Chain 2377 10019, 17661, 25303, 32945, 40587, 48229, 55871 anti-HIV_119-087048_VR-Chain 2378 10020, 17662, 25304, 32946, 40588, 48230, 55872 anti-HIV_119-085802_VR-Chain 2379 10021, 17663, 25305, 32947, 40589, 48231, 55873 anti-HIV_119-085784_VR-Chain 2380 10022, 17664, 25306, 32948, 40590, 48232, 55874 anti-HIV_119-085370_VR-Chain 2381 10023, 17665, 25307, 32949, 40591, 48233, 55875 anti-HIV_119-085276_VR-Chain 2382 10024, 17666, 25308, 32950, 40592, 48234, 55876 anti-HIV_119-084885_VR-Chain 2383 10025, 17667, 25309, 32951, 40593, 48235, 55877 anti-HIV_119-084874_VR-Chain 2384 10026, 17668, 25310, 32952, 40594, 48236, 55878 anti-HIV_119-084691_VR-Chain 2385 10027, 17669, 25311, 32953, 40595, 48237, 55879 anti-HIV_119-083793_VR-Chain 2386 10028, 17670, 25312, 32954, 40596, 48238, 55880 anti-HIV_119-083163_VR-Chain 2387 10029, 17671, 25313, 32955, 40597, 48239, 55881 anti-HIV_119-082331_VR-Chain 2388 10030, 17672, 25314, 32956, 40598, 48240, 55882 anti-HIV_119-082070_VR-Chain 2389 10031, 17673, 25315, 32957, 40599, 48241, 55883 anti-HIV_119-081512_VR-Chain 2390 10032, 17674, 25316, 32958, 40600, 48242, 55884 anti-HIV_119-080816_VR-Chain 2391 10033, 17675, 25317, 32959, 40601, 48243, 55885 anti-HIV_119-079302_VR-Chain 2392 10034, 17676, 25318, 32960, 40602, 48244, 55886 anti-HIV_119-079292_VR-Chain 2393 10035, 17677, 25319, 32961, 40603, 48245, 55887 anti-HIV_119-079289_VR-Chain 2394 10036, 17678, 25320, 32962, 40604, 48246, 55888 anti-HIV_119-078935_VR-Chain 2395 10037, 17679, 25321, 32963, 40605, 48247, 55889 anti-HIV_119-078702_VR-Chain 2396 10038, 17680, 25322, 32964, 40606, 48248, 55890 anti-HIV_119-078593_VR-Chain 2397 10039, 17681, 25323, 32965, 40607, 48249, 55891 anti-HIV_119-077708_VR-Chain 2398 10040, 17682, 25324, 32966, 40608, 48250, 55892 anti-HIV_119-076904_VR-Chain 2399 10041, 17683, 25325, 32967, 40609, 48251, 55893 anti-HIV_119-075862_VR-Chain 2400 10042, 17684, 25326, 32968, 40610, 48252, 55894 anti-HIV_119-075465_VR-Chain 2401 10043, 17685, 25327, 32969, 40611, 48253, 55895 anti-HIV_119-074822_VR-Chain 2402 10044, 17686, 25328, 32970, 40612, 48254, 55896 anti-HIV_119-074629_VR-Chain 2403 10045, 17687, 25329, 32971, 40613, 48255, 55897 anti-HIV_119-074500_VR-Chain 2404 10046, 17688, 25330, 32972, 40614, 48256, 55898 anti-HIV_119-073911_VR-Chain 2405 10047, 17689, 25331, 32973, 40615, 48257, 55899 anti-HIV_119-072765_VR-Chain 2406 10048, 17690, 25332, 32974, 40616, 48258, 55900 anti-HIV_119-072313_VR-Chain 2407 10049, 17691, 25333, 32975, 40617, 48259, 55901 anti-HIV_119-072280_VR-Chain 2408 10050, 17692, 25334, 32976, 40618, 48260, 55902 anti-HIV_119-071693_VR-Chain 2409 10051, 17693, 25335, 32977, 40619, 48261, 55903 anti-HIV_119-071353_VR-Chain 2410 10052, 17694, 25336, 32978, 40620, 48262, 55904 anti-HIV_119-069711_VR-Chain 2411 10053, 17695, 25337, 32979, 40621, 48263, 55905 anti-HIV_119-069061_VR-Chain 2412 10054, 17696, 25338, 32980, 40622, 48264, 55906 anti-HIV_119-068202_VR-Chain 2413 10055, 17697, 25339, 32981, 40623, 48265, 55907 anti-HIV_119-068063_VR-Chain 2414 10056, 17698, 25340, 32982, 40624, 48266, 55908 anti-HIV_119-067980_VR-Chain 2415 10057, 17699, 25341, 32983, 40625, 48267, 55909 anti-HIV_119-067866_VR-Chain 2416 10058, 17700, 25342, 32984, 40626, 48268, 55910 anti-HIV_119-067756_VR-Chain 2417 10059, 17701, 25343, 32985, 40627, 48269, 55911 anti-HIV_119-066859_VR-Chain 2418 10060, 17702, 25344, 32986, 40628, 48270, 55912 anti-HIV_119-065821_VR-Chain 2419 10061, 17703, 25345, 32987, 40629, 48271, 55913 anti-HIV_119-065191_VR-Chain 2420 10062, 17704, 25346, 32988, 40630, 48272, 55914 anti-HIV_119-064667_VR-Chain 2421 10063, 17705, 25347, 32989, 40631, 48273, 55915 anti-HIV_119-063791_VR-Chain 2422 10064, 17706, 25348, 32990, 40632, 48274, 55916 anti-HIV_119-062989_VR-Chain 2423 10065, 17707, 25349, 32991, 40633, 48275, 55917 anti-HIV_119-062286_VR-Chain 2424 10066, 17708, 25350, 32992, 40634, 48276, 55918 anti-HIV_119-061416_VR-Chain 2425 10067, 17709, 25351, 32993, 40635, 48277, 55919 anti-HIV_119-061344_VR-Chain 2426 10068, 17710, 25352, 32994, 40636, 48278, 55920 anti-HIV_119-060240_VR-Chain 2427 10069, 17711, 25353, 32995, 40637, 48279, 55921 anti-HIV_119-060184_VR-Chain 2428 10070, 17712, 25354, 32996, 40638, 48280, 55922 anti-HIV_119-058035_VR-Chain 2429 10071, 17713, 25355, 32997, 40639, 48281, 55923 anti-HIV_119-057858_VR-Chain 2430 10072, 17714, 25356, 32998, 40640, 48282, 55924 anti-HIV_119-057473_VR-Chain 2431 10073, 17715, 25357, 32999, 40641, 48283, 55925 anti-HIV_119-057090_VR-Chain 2432 10074, 17716, 25358, 33000, 40642, 48284, 55926 anti-HIV_119-055754_VR-Chain 2433 10075, 17717, 25359, 33001, 40643, 48285, 55927 anti-HIV_119-054899_VR-Chain 2434 10076, 17718, 25360, 33002, 40644, 48286, 55928 anti-HIV_119-054501_VR-Chain 2435 10077, 17719, 25361, 33003, 40645, 48287, 55929 anti-HIV_119-051867_VR-Chain 2436 10078, 17720, 25362, 33004, 40646, 48288, 55930 anti-HIV_119-051814_VR-Chain 2437 10079, 17721, 25363, 33005, 40647, 48289, 55931 anti-HIV_119-051567_VR-Chain 2438 10080, 17722, 25364, 33006, 40648, 48290, 55932 anti-HIV_119-051483_VR-Chain 2439 10081, 17723, 25365, 33007, 40649, 48291, 55933 anti-HIV_119-050913_VR-Chain 2440 10082, 17724, 25366, 33008, 40650, 48292, 55934 anti-HIV_119-050187_VR-Chain 2441 10083, 17725, 25367, 33009, 40651, 48293, 55935 anti-HIV_119-049069_VR-Chain 2442 10084, 17726, 25368, 33010, 40652, 48294, 55936 anti-HIV_119-048517_VR-Chain 2443 10085, 17727, 25369, 33011, 40653, 48295, 55937 anti-HIV_119-048470_VR-Chain 2444 10086, 17728, 25370, 33012, 40654, 48296, 55938 anti-HIV_119-048303_VR-Chain 2445 10087, 17729, 25371, 33013, 40655, 48297, 55939 anti-HIV_119-048021_VR-Chain 2446 10088, 17730, 25372, 33014, 40656, 48298, 55940 anti-HIV_119-047928_VR-Chain 2447 10089, 17731, 25373, 33015, 40657, 48299, 55941 anti-HIV_119-047384_VR-Chain 2448 10090, 17732, 25374, 33016, 40658, 48300, 55942 anti-HIV_119-047145_VR-Chain 2449 10091, 17733, 25375, 33017, 40659, 48301, 55943 anti-HIV_119-046752_VR-Chain 2450 10092, 17734, 25376, 33018, 40660, 48302, 55944 anti-HIV_119-046660_VR-Chain 2451 10093, 17735, 25377, 33019, 40661, 48303, 55945 anti-HIV_119-046202_VR-Chain 2452 10094, 17736, 25378, 33020, 40662, 48304, 55946 anti-HIV_119-045790_VR-Chain 2453 10095, 17737, 25379, 33021, 40663, 48305, 55947 anti-HIV_119-044670_VR-Chain 2454 10096, 17738, 25380, 33022, 40664, 48306, 55948 anti-HIV_119-044140_VR-Chain 2455 10097, 17739, 25381, 33023, 40665, 48307, 55949 anti-HIV_119-042776_VR-Chain 2456 10098, 17740, 25382, 33024, 40666, 48308, 55950 anti-HIV_119-042581_VR-Chain 2457 10099, 17741, 25383, 33025, 40667, 48309, 55951 anti-HIV_119-040905_VR-Chain 2458 10100, 17742, 25384, 33026, 40668, 48310, 55952 anti-HIV_119-040322_VR-Chain 2459 10101, 17743, 25385, 33027, 40669, 48311, 55953 anti-HIV_119-039892_VR-Chain 2460 10102, 17744, 25386, 33028, 40670, 48312, 55954 anti-HIV_119-039764_VR-Chain 2461 10103, 17745, 25387, 33029, 40671, 48313, 55955 anti-HIV_119-039188_VR-Chain 2462 10104, 17746, 25388, 33030, 40672, 48314, 55956 anti-HIV_119-039058_VR-Chain 2463 10105, 17747, 25389, 33031, 40673, 48315, 55957 anti-HIV_119-038837_VR-Chain 2464 10106, 17748, 25390, 33032, 40674, 48316, 55958 anti-HIV_119-038396_VR-Chain 2465 10107, 17749, 25391, 33033, 40675, 48317, 55959 anti-HIV_119-036918_VR-Chain 2466 10108, 17750, 25392, 33034, 40676, 48318, 55960 anti-HIV_119-036592_VR-Chain 2467 10109, 17751, 25393, 33035, 40677, 48319, 55961 anti-HIV_119-036310_VR-Chain 2468 10110, 17752, 25394, 33036, 40678, 48320, 55962 anti-HIV_119-035618_VR-Chain 2469 10111, 17753, 25395, 33037, 40679, 48321, 55963 anti-HIV_119-035569_VR-Chain 2470 10112, 17754, 25396, 33038, 40680, 48322, 55964 anti-HIV_119-035466_VR-Chain 2471 10113, 17755, 25397, 33039, 40681, 48323, 55965 anti-HIV_119-035157_VR-Chain 2472 10114, 17756, 25398, 33040, 40682, 48324, 55966 anti-HIV_119-035121_VR-Chain 2473 10115, 17757, 25399, 33041, 40683, 48325, 55967 anti-HIV_119-035046_VR-Chain 2474 10116, 17758, 25400, 33042, 40684, 48326, 55968 anti-HIV_119-034754_VR-Chain 2475 10117, 17759, 25401, 33043, 40685, 48327, 55969 anti-HIV_119-034318_VR-Chain 2476 10118, 17760, 25402, 33044, 40686, 48328, 55970 anti-HIV_119-033780_VR-Chain 2477 10119, 17761, 25403, 33045, 40687, 48329, 55971 anti-HIV_119-033632_VR-Chain 2478 10120, 17762, 25404, 33046, 40688, 48330, 55972 anti-HIV_119-033183_VR-Chain 2479 10121, 17763, 25405, 33047, 40689, 48331, 55973 anti-HIV_119-030696_VR-Chain 2480 10122, 17764, 25406, 33048, 40690, 48332, 55974 anti-HIV_119-030059_VR-Chain 2481 10123, 17765, 25407, 33049, 40691, 48333, 55975 anti-HIV_119-029589_VR-Chain 2482 10124, 17766, 25408, 33050, 40692, 48334, 55976 anti-HIV_119-029448_VR-Chain 2483 10125, 17767, 25409, 33051, 40693, 48335, 55977 anti-HIV_119-029220_VR-Chain 2484 10126, 17768, 25410, 33052, 40694, 48336, 55978 anti-HIV_119-028317_VR-Chain 2485 10127, 17769, 25411, 33053, 40695, 48337, 55979 anti-HIV_119-028165_VR-Chain 2486 10128, 17770, 25412, 33054, 40696, 48338, 55980 anti-HIV_119-027147_VR-Chain 2487 10129, 17771, 25413, 33055, 40697, 48339, 55981 anti-HIV_119-026743_VR-Chain 2488 10130, 17772, 25414, 33056, 40698, 48340, 55982 anti-HIV_119-026508_VR-Chain 2489 10131, 17773, 25415, 33057, 40699, 48341, 55983 anti-HIV_119-025683_VR-Chain 2490 10132, 17774, 25416, 33058, 40700, 48342, 55984 anti-HIV_119-025614_VR-Chain 2491 10133, 17775, 25417, 33059, 40701, 48343, 55985 anti-HIV_119-025548_VR-Chain 2492 10134, 17776, 25418, 33060, 40702, 48344, 55986 anti-HIV_119-025526_VR-Chain 2493 10135, 17777, 25419, 33061, 40703, 48345, 55987 anti-HIV_119-023552_VR-Chain 2494 10136, 17778, 25420, 33062, 40704, 48346, 55988 anti-HIV_119-023092_VR-Chain 2495 10137, 17779, 25421, 33063, 40705, 48347, 55989 anti-HIV_119-022793_VR-Chain 2496 10138, 17780, 25422, 33064, 40706, 48348, 55990 anti-HIV_119-022395_VR-Chain 2497 10139, 17781, 25423, 33065, 40707, 48349, 55991 anti-HIV_119-022334_VR-Chain 2498 10140, 17782, 25424, 33066, 40708, 48350, 55992 anti-HIV_119-021866_VR-Chain 2499 10141, 17783, 25425, 33067, 40709, 48351, 55993 anti-HIV_119-021278_VR-Chain 2500 10142, 17784, 25426, 33068, 40710, 48352, 55994 anti-HIV_119-021183_VR-Chain 2501 10143, 17785, 25427, 33069, 40711, 48353, 55995 anti-HIV_119-019376_VR-Chain 2502 10144, 17786, 25428, 33070, 40712, 48354, 55996 anti-HIV_119-019238_VR-Chain 2503 10145, 17787, 25429, 33071, 40713, 48355, 55997 anti-HIV_119-018500_VR-Chain 2504 10146, 17788, 25430, 33072, 40714, 48356, 55998 anti-HIV_119-018318_VR-Chain 2505 10147, 17789, 25431, 33073, 40715, 48357, 55999 anti-HIV_119-018218_VR-Chain 2506 10148, 17790, 25432, 33074, 40716, 48358, 56000 anti-HIV_119-017876_VR-Chain 2507 10149, 17791, 25433, 33075, 40717, 48359, 56001 anti-HIV_119-017740_VR-Chain 2508 10150, 17792, 25434, 33076, 40718, 48360, 56002 anti-HIV_119-017128_VR-Chain 2509 10151, 17793, 25435, 33077, 40719, 48361, 56003 anti-HIV_119-017044_VR-Chain 2510 10152, 17794, 25436, 33078, 40720, 48362, 56004 anti-HIV_119-016644_VR-Chain 2511 10153, 17795, 25437, 33079, 40721, 48363, 56005 anti-HIV_119-015878_VR-Chain 2512 10154, 17796, 25438, 33080, 40722, 48364, 56006 anti-HIV_119-015538_VR-Chain 2513 10155, 17797, 25439, 33081, 40723, 48365, 56007 anti-HIV_119-015455_VR-Chain 2514 10156, 17798, 25440, 33082, 40724, 48366, 56008 anti-HIV_119-014425_VR-Chain 2515 10157, 17799, 25441, 33083, 40725, 48367, 56009 anti-HIV_119-013582_VR-Chain 2516 10158, 17800, 25442, 33084, 40726, 48368, 56010 anti-HIV_119-013364_VR-Chain 2517 10159, 17801, 25443, 33085, 40727, 48369, 56011 anti-HIV_119-012886_VR-Chain 2518 10160, 17802, 25444, 33086, 40728, 48370, 56012 anti-HIV_119-012249_VR-Chain 2519 10161, 17803, 25445, 33087, 40729, 48371, 56013 anti-HIV_119-012161_VR-Chain 2520 10162, 17804, 25446, 33088, 40730, 48372, 56014 anti-HIV_119-012110_VR-Chain 2521 10163, 17805, 25447, 33089, 40731, 48373, 56015 anti-HIV_119-012100_VR-Chain 2522 10164, 17806, 25448, 33090, 40732, 48374, 56016 anti-HIV_119-011651_VR-Chain 2523 10165, 17807, 25449, 33091, 40733, 48375, 56017 anti-HIV_119-011479_VR-Chain 2524 10166, 17808, 25450, 33092, 40734, 48376, 56018 anti-HIV_119-011232_VR-Chain 2525 10167, 17809, 25451, 33093, 40735, 48377, 56019 anti-HIV_119-011175_VR-Chain 2526 10168, 17810, 25452, 33094, 40736, 48378, 56020 anti-HIV_119-008396_VR-Chain 2527 10169, 17811, 25453, 33095, 40737, 48379, 56021 anti-HIV_119-007148_VR-Chain 2528 10170, 17812, 25454, 33096, 40738, 48380, 56022 anti-HIV_119-007029_VR-Chain 2529 10171, 17813, 25455, 33097, 40739, 48381, 56023 anti-HIV_119-004707_VR-Chain 2530 10172, 17814, 25456, 33098, 40740, 48382, 56024 anti-HIV_119-003910_VR-Chain 2531 10173, 17815, 25457, 33099, 40741, 48383, 56025 anti-HIV_119-002450_VR-Chain 2532 10174, 17816, 25458, 33100, 40742, 48384, 56026 anti-HIV_119-001552_VR-Chain 2533 10175, 17817, 25459, 33101, 40743, 48385, 56027 anti-HIV_059-188169_VR-Chain 2534 10176, 17818, 25460, 33102, 40744, 48386, 56028 anti-HIV_059-183739_VR-Chain 2535 10177, 17819, 25461, 33103, 40745, 48387, 56029 anti-HIV_059-182376_VR-Chain 2536 10178, 17820, 25462, 33104, 40746, 48388, 56030 anti-HIV_059-182199_VR-Chain 2537 10179, 17821, 25463, 33105, 40747, 48389, 56031 anti-HIV_059-169202_VR-Chain 2538 10180, 17822, 25464, 33106, 40748, 48390, 56032 anti-HIV_059-155645_VR-Chain 2539 10181, 17823, 25465, 33107, 40749, 48391, 56033 anti-HIV_059-151619_VR-Chain 2540 10182, 17824, 25466, 33108, 40750, 48392, 56034 anti-HIV_059-146503_VR-Chain 2541 10183, 17825, 25467, 33109, 40751, 48393, 56035 anti-HIV_059-136098_VR-Chain 2542 10184, 17826, 25468, 33110, 40752, 48394, 56036 anti-HIV_059-105516_VR-Chain 2543 10185, 17827, 25469, 33111, 40753, 48395, 56037 anti-HIV_059-095709_VR-Chain 2544 10186, 17828, 25470, 33112, 40754, 48396, 56038 anti-HIV_059-069468_VR-Chain 2545 10187, 17829, 25471, 33113, 40755, 48397, 56039 anti-HIV_059-060026_VR-Chain 2546 10188, 17830, 25472, 33114, 40756, 48398, 56040 anti-HIV_059-053668_VR-Chain 2547 10189, 17831, 25473, 33115, 40757, 48399, 56041 anti-HIV_059-052864_VR-Chain 2548 10190, 17832, 25474, 33116, 40758, 48400, 56042 anti-HIV_059-050968_VR-Chain 2549 10191, 17833, 25475, 33117, 40759, 48401, 56043 anti-HIV_059-046422_VR-Chain 2550 10192, 17834, 25476, 33118, 40760, 48402, 56044 anti-HIV_059-045120_VR-Chain 2551 10193, 17835, 25477, 33119, 40761, 48403, 56045 anti-HIV_059-039932_VR-Chain 2552 10194, 17836, 25478, 33120, 40762, 48404, 56046 anti-HIV_059-038595_VR-Chain 2553 10195, 17837, 25479, 33121, 40763, 48405, 56047 anti-HIV_059-035082_VR-Chain 2554 10196, 17838, 25480, 33122, 40764, 48406, 56048 anti-HIV_059-029204_VR-Chain 2555 10197, 17839, 25481, 33123, 40765, 48407, 56049 anti-HIV_059-025235_VR-Chain 2556 10198, 17840, 25482, 33124, 40766, 48408, 56050 anti-HIV_059-015192_VR-Chain 2557 10199, 17841, 25483, 33125, 40767, 48409, 56051 anti-HIV_059-007060_VR-Chain 2558 10200, 17842, 25484, 33126, 40768, 48410, 56052 anti-HIV_059-006953_VR-Chain 2559 10201, 17843, 25485, 33127, 40769, 48411, 56053 anti-HIV_059-005953_VR-Chain 2560 10202, 17844, 25486, 33128, 40770, 48412, 56054 anti-HIV_059-003725_VR-Chain 2561 10203, 17845, 25487, 33129, 40771, 48413, 56055 anti-HIV_059-002618_VR-Chain 2562 10204, 17846, 25488, 33130, 40772, 48414, 56056 anti-HIV_059-001522_VR-Chain 2563 10205, 17847, 25489, 33131, 40773, 48415, 56057 anti-HIV_059-000731_VR-Chain 2564 10206, 17848, 25490, 33132, 40774, 48416, 56058 anti-HIV_059-000634_VR-Chain 2565 10207, 17849, 25491, 33133, 40775, 48417, 56059 anti-HIV_048-250757_VR-Chain 2566 10208, 17850, 25492, 33134, 40776, 48418, 56060 anti-HIV_048-250716_VR-Chain 2567 10209, 17851, 25493, 33135, 40777, 48419, 56061 anti-HIV_048-250463_VR-Chain 2568 10210, 17852, 25494, 33136, 40778, 48420, 56062 anti-HIV_048-248153_VR-Chain 2569 10211, 17853, 25495, 33137, 40779, 48421, 56063 anti-HIV_048-247532_VR-Chain 2570 10212, 17854, 25496, 33138, 40780, 48422, 56064 anti-HIV_048-245846_VR-Chain 2571 10213, 17855, 25497, 33139, 40781, 48423, 56065 anti-HIV_048-244016_VR-Chain 2572 10214, 17856, 25498, 33140, 40782, 48424, 56066 anti-HIV_048-243682_VR-Chain 2573 10215, 17857, 25499, 33141, 40783, 48425, 56067 anti-HIV_048-243588_VR-Chain 2574 10216, 17858, 25500, 33142, 40784, 48426, 56068 anti-HIV_048-241775_VR-Chain 2575 10217, 17859, 25501, 33143, 40785, 48427, 56069 anti-HIV_048-237996_VR-Chain 2576 10218, 17860, 25502, 33144, 40786, 48428, 56070 anti-HIV_048-237730_VR-Chain 2577 10219, 17861, 25503, 33145, 40787, 48429, 56071 anti-HIV_048-237253_VR-Chain 2578 10220, 17862, 25504, 33146, 40788, 48430, 56072 anti-HIV_048-234100_VR-Chain 2579 10221, 17863, 25505, 33147, 40789, 48431, 56073 anti-HIV_048-230882_VR-Chain 2580 10222, 17864, 25506, 33148, 40790, 48432, 56074 anti-HIV_048-229473_VR-Chain 2581 10223, 17865, 25507, 33149, 40791, 48433, 56075 anti-HIV_048-228238_VR-Chain 2582 10224, 17869, 25508, 33150, 40792, 48434, 56079 anti-HIV_048-228027_VR-Chain 2583 10225, 17867, 25509, 33151, 40793, 48435, 56077 anti-HIV_048-227795_VR-Chain 2584 10226, 17868, 25510, 33152, 40794, 48436, 56078 anti-HIV_048-227770_VR-Chain 2585 10227, 17869, 25511, 33153, 40795, 48437, 56079 anti-HIV_048-225298_VR-Chain 2586 10228, 17870, 25512, 33154, 40796, 48438, 56080 anti-HIV_048-225090_VR-Chain 2587 10229, 17871, 25513, 33155, 40797, 48439, 56081 anti-HIV_048-224187_VR-Chain 2588 10230, 17872, 25514, 33156, 40798, 48440, 56082 anti-HIV_048-223055_VR-Chain 2589 10231, 17873, 25515, 33157, 40799, 48441, 56083 anti-HIV_048-222711_VR-Chain 2590 10232, 17874, 25516, 33158, 40800, 48442, 56084 anti-HIV_048-221209_VR-Chain 2591 10233, 17875, 25517, 33159, 40801, 48443, 56085 anti-HIV_048-220929_VR-Chain 2592 10234, 17876, 25518, 33160, 40802, 48444, 56086 anti-HIV_048-219430_VR-Chain 2593 10235, 17877, 25519, 33161, 40803, 48445, 56087 anti-HIV_048-216250_VR-Chain 2594 10236, 17878, 25520, 33162, 40804, 48446, 56088 anti-HIV_048-216133_VR-Chain 2595 10237, 17879, 25521, 33163, 40805, 48447, 56089 anti-HIV_048-214886_VR-Chain 2596 10238, 17880, 25522, 33164, 40806, 48448, 56090 anti-HIV_048-214709_VR-Chain 2597 10239, 17881, 25523, 33165, 40807, 48449, 56091 anti-HIV_048-214001_VR-Chain 2598 10240, 17882, 25524, 33166, 40808, 48450, 56092 anti-HIV_048-213230_VR-Chain 2599 10241, 17883, 25525, 33167, 40809, 48451, 56093 anti-HIV_048-212574_VR-Chain 2600 10242, 17884, 25526, 33168, 40810, 48452, 56094 anti-HIV_048-212207_VR-Chain 2601 10243, 17885, 25527, 33169, 40811, 48453, 56095 anti-HIV_048-209146_VR-Chain 2602 10244, 17886, 25528, 33170, 40812, 48454, 56096 anti-HIV_048-208206_VR-Chain 2603 10245, 17887, 25529, 33171, 40813, 48455, 56097 anti-HIV_048-208194_VR-Chain 2604 10246, 17888, 25530, 33172, 40814, 48456, 56098 anti-HIV_048-207744_VR-Chain 2605 10247, 17889, 25531, 33173, 40815, 48457, 56099 anti-HIV_048-206501_VR-Chain 2606 10248, 17890, 25532, 33174, 40816, 48458, 56100 anti-HIV_048-204221_VR-Chain 2607 10249, 17891, 25533, 33175, 40817, 48459, 56101 anti-HIV_048-204015_VR-Chain 2608 10250, 17892, 25534, 33176, 40818, 48460, 56102 anti-HIV_048-201240_VR-Chain 2609 10251, 17893, 25535, 33177, 40819, 48461, 56103 anti-HIV_048-200455_VR-Chain 2610 10252, 17894, 25536, 33178, 40820, 48462, 56104 anti-HIV_048-200319_VR-Chain 2611 10253, 17895, 25537, 33179, 40821, 48463, 56105 anti-HIV_048-197896_VR-Chain 2612 10254, 17896, 25538, 33180, 40822, 48464, 56106 anti-HIV_048-193813_VR-Chain 2613 10255, 17897, 25539, 33181, 40823, 48465, 56107 anti-HIV_048-192098_VR-Chain 2614 10256, 17898, 25540, 33182, 40824, 48466, 56108 anti-HIV_048-191786_VR-Chain 2615 10257, 17899, 25541, 33183, 40825, 48467, 56109 anti-HIV_048-188746_VR-Chain 2616 10258, 17900, 25542, 33184, 40826, 48468, 56110 anti-HIV_048-185937_VR-Chain 2617 10259, 17901, 25543, 33185, 40827, 48469, 56111 anti-HIV_048-184849_VR-Chain 2618 10260, 17902, 25544, 33186, 40828, 48470, 56112 anti-HIV_048-183089_VR-Chain 2619 10261, 17903, 25545, 33187, 40829, 48471, 56113 anti-HIV_048-181509_VR-Chain 2620 10262, 17904, 25546, 33188, 40830, 48472, 56114 anti-HIV_048-180990_VR-Chain 2621 10263, 17905, 25547, 33189, 40831, 48473, 56115 anti-HIV_048-177532_VR-Chain 2622 10264, 17906, 25548, 33190, 40832, 48474, 56116 anti-HIV_048-177426_VR-Chain 2623 10265, 17907, 25549, 33191, 40833, 48475, 56117 anti-HIV_048-177389_VR-Chain 2624 10266, 17908, 25550, 33192, 40834, 48476, 56118 anti-HIV_048-174266_VR-Chain 2625 10267, 17909, 25551, 33193, 40835, 48477, 56119 anti-HIV_048-172847_VR-Chain 2626 10268, 17910, 25552, 33194, 40836, 48478, 56120 anti-HIV_048-172845_VR-Chain 2627 10269, 17911, 25553, 33195, 40837, 48479, 56121 anti-HIV_048-172363_VR-Chain 2628 10270, 17912, 25554, 33196, 40838, 48480, 56122 anti-HIV_048-171609_VR-Chain 2629 10271, 17913, 25555, 33197, 40839, 48481, 56123 anti-HIV_048-170705_VR-Chain 2630 10272, 17914, 25556, 33198, 40840, 48482, 56124 anti-HIV_048-168381_VR-Chain 2631 10273, 17915, 25557, 33199, 40841, 48483, 56125 anti-HIV_048-166619_VR-Chain 2632 10274, 17916, 25558, 33200, 40842, 48484, 56126 anti-HIV_048-162036_VR-Chain 2633 10275, 17917, 25559, 33201, 40843, 48485, 56127 anti-HIV_048-160042_VR-Chain 2634 10276, 17918, 25560, 33202, 40844, 48486, 56128 anti-HIV_048-159676_VR-Chain 2635 10277, 17919, 25561, 33203, 40845, 48487, 56129 anti-HIV_048-159500_VR-Chain 2636 10278, 17920, 25562, 33204, 40846, 48488, 56130 anti-HIV_048-159421_VR-Chain 2637 10279, 17921, 25563, 33205, 40847, 48489, 56131 anti-HIV_048-159333_VR-Chain 2638 10280, 17922, 25564, 33206, 40848, 48490, 56132 anti-HIV_048-158932_VR-Chain 2639 10281, 17923, 25565, 33207, 40849, 48491, 56133 anti-HIV_048-155811_VR-Chain 2640 10282, 17924, 25566, 33208, 40850, 48492, 56134 anti-HIV_048-155464_VR-Chain 2641 10283, 17925, 25567, 33209, 40851, 48493, 56135 anti-HIV_048-155392_VR-Chain 2642 10284, 17926, 25568, 33210, 40852, 48494, 56136 anti-HIV_048-155389_VR-Chain 2643 10285, 17927, 25569, 33211, 40853, 48495, 56137 anti-HIV_048-154449_VR-Chain 2644 10286, 17928, 25570, 33212, 40854, 48496, 56138 anti-HIV_048-153379_VR-Chain 2645 10287, 17929, 25571, 33213, 40855, 48497, 56139 anti-HIV_048-153171_VR-Chain 2646 10288, 17930, 25572, 33214, 40856, 48498, 56140 anti-HIV_048-152324_VR-Chain 2647 10289, 17931, 25573, 33215, 40857, 48499, 56141 anti-HIV_048-146102_VR-Chain 2648 10290, 17932, 25574, 33216, 40858, 48500, 56142 anti-HIV_048-145984_VR-Chain 2649 10291, 17933, 25575, 33217, 40859, 48501, 56143 anti-HIV_048-145371_VR-Chain 2650 10292, 17934, 25576, 33218, 40860, 48502, 56144 anti-HIV_048-144907_VR-Chain 2651 10293, 17935, 25577, 33219, 40861, 48503, 56145 anti-HIV_048-142298_VR-Chain 2652 10294, 17936, 25578, 33220, 40862, 48504, 56146 anti-HIV_048-142277_VR-Chain 2653 10295, 17937, 25579, 33221, 40863, 48505, 56147 anti-HIV_048-141934_VR-Chain 2654 10296, 17938, 25580, 33222, 40864, 48506, 56148 anti-HIV_048-141207_VR-Chain 2655 10297, 17939, 25581, 33223, 40865, 48507, 56149 anti-HIV_048-140796_VR-Chain 2656 10298, 17940, 25582, 33224, 40866, 48508, 56150 anti-HIV_048-139893_VR-Chain 2657 10299, 17941, 25583, 33225, 40867, 48509, 56151 anti-HIV_048-138820_VR-Chain 2658 10300, 17942, 25584, 33226, 40868, 48510, 56152 anti-HIV_048-135858_VR-Chain 2659 10301, 17943, 25585, 33227, 40869, 48511, 56153 anti-HIV_048-134968_VR-Chain 2660 10302, 17944, 25586, 33228, 40870, 48512, 56154 anti-HIV_048-134312_VR-Chain 2661 10303, 17945, 25587, 33229, 40871, 48513, 56155 anti-HIV_048-132253_VR-Chain 2662 10304, 17946, 25588, 33230, 40872, 48514, 56156 anti-HIV_048-130710_VR-Chain 2663 10305, 17947, 25589, 33231, 40873, 48515, 56157 anti-HIV_048-128564_VR-Chain 2664 10306, 17948, 25590, 33232, 40874, 48516, 56158 anti-HIV_048-126702_VR-Chain 2665 10307, 17949, 25591, 33233, 40875, 48517, 56159 anti-HIV_048-124521_VR-Chain 2666 10308, 17950, 25592, 33234, 40876, 48518, 56160 anti-HIV_048-122740_VR-Chain 2667 10309, 17951, 25593, 33235, 40877, 48519, 56161 anti-HIV_048-119536_VR-Chain 2668 10310, 17952, 25594, 33236, 40878, 48520, 56162 anti-HIV_048-116929_VR-Chain 2669 10311, 17953, 25595, 33237, 40879, 48521, 56163 anti-HIV_048-116577_VR-Chain 2670 10312, 17954, 25596, 33238, 40880, 48522, 56164 anti-HIV_048-116045_VR-Chain 2671 10313, 17955, 25597, 33239, 40881, 48523, 56165 anti-HIV_048-115875_VR-Chain 2672 10314, 17956, 25598, 33240, 40882, 48524, 56166 anti-HIV_048-115599_VR-Chain 2673 10315, 17957, 25599, 33241, 40883, 48525, 56167 anti-HIV_048-113988_VR-Chain 2674 10316, 17958, 25600, 33242, 40884, 48526, 56168 anti-HIV_048-112989_VR-Chain 2675 10317, 17959, 25601, 33243, 40885, 48527, 56169 anti-HIV_048-112435_VR-Chain 2676 10318, 17960, 25602, 33244, 40886, 48528, 56170 anti-HIV_048-111339_VR-Chain 2677 10319, 17961, 25603, 33245, 40887, 48529, 56171 anti-HIV_048-111055_VR-Chain 2678 10320, 17962, 25604, 33246, 40888, 48530, 56172 anti-HIV_048-111027_VR-Chain 2679 10321, 17963, 25605, 33247, 40889, 48531, 56173 anti-HIV_048-109721_VR-Chain 2080 10322, 17964, 25606, 33248, 40890, 48532, 56174 anti-HIV_048-109666_VR-Chain 2681 10323, 17965, 25607, 33249, 40891, 48533, 56175 anti-HIV_048-109196_VR-Chain 2682 10324, 17966, 25608, 33250, 40892, 48534, 56176 anti-HIV_048-109051_VR-Chain 2683 10325, 17967, 25609, 33251, 40893, 48535, 56177 anti-HIV_048-108570_VR-Chain 2684 10326, 17968, 25610, 33252, 40894, 48536, 56178 anti-HIV_048-108033_VR-Chain 2685 10327, 17969, 25611, 33253, 40895, 48537, 56179 anti-HIV_048-107279_VR-Chain 2686 10328, 17970, 25612, 33254, 40896, 48538, 56180 anti-HIV_048-106271_VR-Chain 2687 10329, 17971, 25613, 33255, 40897, 48539, 56181 anti-HIV_048-106054_VR-Chain 2688 10330, 17972, 25614, 33256, 40898, 48540, 56182 anti-HIV_048-104848_VR-Chain 2689 10331, 17973, 25615, 33257, 40899, 48541, 56183 anti-HIV_048-104638_VR-Chain 2690 10332, 17974, 25616, 33258, 40900, 48542, 56184 anti-HIV_048-104567_VR-Chain 2691 10333, 17975, 25617, 33259, 40901, 48543, 56185 anti-HIV_048-102804_VR-Chain 2692 10334, 17976, 25618, 33260, 40902, 48544, 56186 anti-HIV_048-101676_VR-Chain 2693 10335, 17977, 25619, 33261, 40903, 48545, 56187 anti-HIV_048-097603_VR-Chain 2694 10336, 17978, 25620, 33262, 40904, 48546, 56188 anti-HIV_048-097107_VR-Chain 2695 10337, 17979, 25621, 33263, 40905, 48547, 56189 anti-HIV_048-096871_VR-Chain 2696 10338, 17980, 25622, 33264, 40906, 48548, 56190 anti-HIV_048-096668_VR-Chain 2697 10339, 17981, 25623, 33265, 40907, 48549, 56191 anti-HIV_048-095236_VR-Chain 2698 10340, 17982, 25624, 33266, 40908, 48550, 56192 anti-HIV_048-094155_VR-Chain 2699 10341, 17983, 25625, 33267, 40909, 48551, 56193 anti-HIV_048-093219_VR-Chain 2700 10342, 17984, 25626, 33268, 40910, 48552, 56194 anti-HIV_048-092976_VR-Chain 2701 10343, 17985, 25627, 33269, 40911, 48553, 56195 anti-HIV_048-090866_VR-Chain 2702 10344, 17986, 25628, 33270, 40912, 48554, 56196 anti-HIV_048-090650_VR-Chain 2703 10345, 17987, 25629, 33271, 40913, 48555, 56197 anti-HIV_048-089009_VR-Chain 2704 10346, 17988, 25630, 33272, 40914, 48556, 56198 anti-HIV_048-088654_VR-Chain 2705 10347, 17989, 25631, 33273, 40915, 48557, 56199 anti-HIV_048-086513_VR-Chain 2706 10348, 17990, 25632, 33274, 40916, 48558, 56200 anti-HIV_048-086024_VR-Chain 2707 10349, 17991, 25633, 33275, 40917, 48559, 56201 anti-HIV_048-085857_VR-Chain 2708 10350, 17992, 25634, 33276, 40918, 48560, 56202 anti-HIV_048-084277_VR-Chain 2709 10351, 17993, 25635, 33277, 40919, 48561, 56203 anti-HIV_048-084245_VR-Chain 2710 10352, 17994, 25636, 33278, 40920, 48562, 56204 anti-HIV_048-082487_VR-Chain 2711 10353, 17995, 25637, 33279, 40921, 48563, 56205 anti-HIV_048-081787_VR-Chain 2712 10354, 17996, 25638, 33280, 40922, 48564, 56206 anti-HIV_048-081062_VR-Chain 2713 10355, 17997, 25639, 33281, 40923, 48565, 56207 anti-HIV_048-079639_VR-Chain 2714 10356, 17998, 25640, 33282, 40924, 48566, 56208 anti-HIV_048-079126_VR-Chain 2715 10357, 17999, 25641, 33283, 40925, 48567, 56209 anti-HIV_048-073118_VR-Chain 2716 10358, 18000, 25642, 33284, 40926, 48568, 56210 anti-HIV_048-070264_VR-Chain 2717 10359, 18001, 25643, 33285, 40927, 48569, 56211 anti-HIV_048-069426_VR-Chain 2718 10360, 18002, 25644, 33286, 40928, 48570, 56212 anti-HIV_048-068564_VR-Chain 2719 10361, 18003, 25645, 33287, 40929, 48571, 56213 anti-HIV_048-068345_VR-Chain 2720 10362, 18004, 25646, 33288, 40930, 48572, 56214 anti-HIV_048-067337_VR-Chain 2721 10363, 18005, 25647, 33289, 40931, 48573, 56215 anti-HIV_048-067180_VR-Chain 2722 10364, 18006, 25648, 33290, 40932, 48574, 56216 anti-HIV_048-063017_VR-Chain 2723 10365, 18007, 25649, 33291, 40933, 48575, 56217 anti-HIV_048-061885_VR-Chain 2724 10366, 18008, 25650, 33292, 40934, 48576, 56218 anti-HIV_048-061671_VR-Chain 2725 10367, 18009, 25651, 33293, 40935, 48577, 56219 anti-HIV_048-060700_VR-Chain 2726 10368, 18010, 25652, 33294, 40936, 48578, 56220 anti-HIV_048-060592_VR-Chain 2727 10369, 18011, 25653, 33295, 40937, 48579, 56221 anti-HIV_048-060300_VR-Chain 2728 10370, 18012, 25654, 33296, 40938, 48580, 56222 anti-HIV_048-059141_VR-Chain 2729 10371, 18013, 25655, 33297, 40939, 48581, 56223 anti-HIV_048-057777_VR-Chain 2730 10372, 18014, 25656, 33298, 40940, 48582, 56224 anti-HIV_048-056928_VR-Chain 2731 10373, 18015, 25657, 33299, 40941, 48583, 56225 anti-HIV_048-056131_VR-Chain 2732 10374, 18016, 25658, 33300, 40942, 48584, 56226 anti-HIV_048-055864_VR-Chain 2733 10375, 18017, 25659, 33301, 40943, 48585, 56227 anti-HIV_048-055094_VR-Chain 2734 10376, 18018, 25660, 33302, 40944, 48586, 56228 anti-HIV_048-054343_VR-Chain 2735 10377, 18019, 25661, 33303, 40945, 48587, 56229 anti-HIV_048-054193_VR-Chain 2736 10378, 18020, 25662, 33304, 40946, 48588, 56230 anti-HIV_048-052521_VR-Chain 2737 10379, 18021, 25663, 33305, 40947, 48589, 56231 anti-HIV_048-049037_VR-Chain 2738 10380, 18022, 25664, 33306, 40948, 48590, 56232 anti-HIV_048-048720_VR-Chain 2739 10381, 18023, 25665, 33307, 40949, 48591, 56233 anti-HIV_048-048542_VR-Chain 2740 10382, 18024, 25666, 33308, 40950, 48592, 56234 anti-HIV_048-047777_VR-Chain 2741 10383, 18025, 25667, 33309, 40951, 48593, 56235 anti-HIV_048-046841_VR-Chain 2742 10384, 18026, 25668, 33310, 40952, 48594, 56236 anti-HIV_048-046202_VR-Chain 2743 10385, 18027, 25669, 33311, 40953, 48595, 56237 anti-HIV_048-046059_VR-Chain 2744 10386, 18028, 25670, 33312, 40954, 48596, 56238 anti-HIV_048-043568_VR-Chain 2745 10387, 18029, 25671, 33313, 40955, 48597, 56239 anti-HIV_048-042713_VR-Chain 2746 10388, 18030, 25672, 33314, 40956, 48598, 56240 anti-HIV_048-042440_VR-Chain 2747 10389, 18031, 25673, 33315, 40957, 48599, 56241 anti-HIV_048-040511_VR-Chain 2748 10390, 18032, 25674, 33316, 40958, 48600, 56242 anti-HIV_048-039195_VR-Chain 2749 10391, 18033, 25675, 33317, 40959, 48601, 56243 anti-HIV_048-036935_VR-Chain 2750 10392, 18034, 25676, 33318, 40960, 48602, 56244 anti-HIV_048-034478_VR-Chain 2751 10393, 18035, 25677, 33319, 40961, 48603, 56245 anti-HIV_048-031641_VR-Chain 2752 10394, 18036, 25678, 33320, 40962, 48604, 56246 anti-HIV_048-029760_VR-Chain 2753 10395, 18037, 25679, 33321, 40963, 48605, 56247 anti-HIV_048-027970_VR-Chain 2754 10396, 18038, 25680, 33322, 40964, 48606, 56248 anti-HIV_048-027337_VR-Chain 2755 10397, 18039, 25681, 33323, 40965, 48607, 56249 anti-HIV_048-027217_VR-Chain 2756 10398, 18040, 25682, 33324, 40966, 48608, 56250 anti-HIV_048-026760_VR-Chain 2757 10399, 18041, 25683, 33325, 40967, 48609, 56251 anti-HIV_048-024800_VR-Chain 2758 10400, 18042, 25684, 33326, 40968, 48610, 56252 anti-HIV_048-024313_VR-Chain 2759 10401, 18043, 25685, 33327, 40969, 48611, 56253 anti-HIV_048-021748_VR-Chain 2760 10402, 18044, 25686, 33328, 40970, 48612, 56254 anti-HIV_048-020991_VR-Chain 2761 10403, 18045, 25687, 33329, 40971, 48613, 56255 anti-HIV_048-020340_VR-Chain 2762 10404, 18046, 25688, 33330, 40972, 48614, 56256 anti-HIV_048-019993_VR-Chain 2763 10405, 18047, 25689, 33331, 40973, 48615, 56257 anti-HIV_048-019947_VR-Chain 2764 10406, 18048, 25690, 33332, 40974, 48616, 56258 anti-HIV_048-017871_VR-Chain 2765 10407, 18049, 25691, 33333, 40975, 48617, 56259 anti-HIV_048-015931_VR-Chain 2766 10408, 18050, 25692, 33334, 40976, 48618, 56260 anti-HIV_048-015920_VR-Chain 2767 10409, 18051, 25693, 33335, 40977, 48619, 56261 anti-HIV_048-013898_VR-Chain 2768 10410, 18052, 25694, 33336, 40978, 48620, 56262 anti-HIV_048-013429_VR-Chain 2769 10411, 18053, 25695, 33337, 40979, 48621, 56263 anti-HIV_048-012358_VR-Chain 2770 10412, 18054, 25696, 33338, 40980, 48622, 56264 anti-HIV_048-011158_VR-Chain 2771 10413, 18055, 25697, 33339, 40981, 48623, 56265 anti-HIV_048-010720_VR-Chain 2772 10414, 18056, 25698, 33340, 40982, 48624, 56266 anti-HIV_048-009445_VR-Chain 2773 10415, 18057, 25699, 33341, 40983, 48625, 56267 anti-HIV_048-006126_VR-Chain 2774 10416, 18058, 25700, 33342, 40984, 48626, 56268 anti-HIV_048-005652_VR-Chain 2775 10417, 18059, 25701, 33343, 40985, 48627, 56269 anti-HIV_048-005532_VR-Chain 2776 10418, 18060, 25702, 33344, 40986, 48628, 56270 anti-HIV_048-005189_VR-Chain 2777 10419, 18061, 25703, 33345, 40987, 48629, 56271 anti-HIV_048-005088_VR-Chain 2778 10420, 18062, 25704, 33346, 40988, 48630, 56272 anti-HIV_048-004023_VR-Chain 2779 10421, 18063, 25705, 33347, 40989, 48631, 56273 anti-HIV_048-001580_VR-Chain 2780 10422, 18064, 25706, 33348, 40990, 48632, 56274 anti-HIV_038-221120_VR-Chain 2781 10423, 18065, 25707, 33349, 40991, 48633, 56275 anti-HIV_038-197677_VR-Chain 2782 10424, 18066, 25708, 33350, 40992, 48634, 56276 anti-HIV_038-196765_VR-Chain 2783 10425, 18067, 25709, 33351, 40993, 48635, 56277 anti-HIV_038-186200_VR-Chain 2784 10426, 18068, 25710, 33352, 40994, 48636, 56278 anti-HIV_038-126170_VR-Chain 2785 10427, 18069, 25711, 33353, 40995, 48637, 56279 anti-HIV_038-108545_VR-Chain 2786 10428, 18070, 25712, 33354, 40996, 48638, 56280 anti-HIV_038-107263_VR-Chain 2787 10429, 18071, 25713, 33355, 40997, 48639, 56281 anti-HIV_038-104530_VR-Chain 2788 10430, 18072, 25714, 33356, 40998, 48640, 56282 anti-HIV_038-099169_VR-Chain 2789 10431, 18073, 25715, 33357, 40999, 48641, 56283 anti-HIV_038-075067_VR-Chain 2790 10432, 18074, 25716, 33358, 41000, 48642, 56284 anti-HIV_038-072368_VR-Chain 2791 10433, 18075, 25717, 33359, 41001, 48643, 56285 anti-HIV_038-068503_VR-Chain 2792 10434, 18076, 25718, 33360, 41002, 48644, 56286 anti-HIV_038-068016_VR-Chain 2793 10435, 18077, 25719, 33361, 41003, 48645, 56287 anti-HIV_038-063958_VR-Chain 2794 10436, 18078, 25720, 33362, 41004, 48646, 56288 anti-HIV_038-033733_VR-Chain 2795 10437, 18079, 25721, 33363, 41005, 48647, 56289 anti-HIV_038-030557_VR-Chain 2796 10438, 18080, 25722, 33364, 41006, 48648, 56290 anti-HIV_038-024298_VR-Chain 2797 10439, 18081, 25723, 33365, 41007, 48649, 56291 anti-HIV_038-011154_VR-Chain 2798 10440, 18082, 25724, 33366, 41008, 48650, 56292 anti-HIV-1_LightChain 2799 10441, 18083, 25725, 33367, 41009, 48651, 56293 anti-HIV-1_LightChain 2800 10442, 18084, 25726, 33368, 41010, 48652, 56294 anti-HIV-1_LightChain 2801 10443, 18085, 25727, 33369, 41011, 48653, 56295 anti-HIV-1_LightChain 2802 10444, 18086, 25728, 33370, 41012, 48654, 56296 anti-HIV-1_LightChain 2803 10445, 18087, 25729, 33371, 41013, 48655, 56297 anti-HIV-1_LightChain 2804 10446, 18088, 25730, 33372, 41014, 48656, 56298 anti-HIV-1_LightChain 2805 10447, 18089, 25731, 33373, 41015, 48657, 56299 anti-HIV-1_LightChain 2806 10448, 18090, 25732, 33374, 41016, 48658, 56300 anti-HIV-1_LightChain 2807 10449, 18091, 25733, 33375, 41017, 48659, 56301 anti-HIV-1_LightChain 2808 10450, 18092, 25734, 33376, 41018, 48660, 56302 anti-HIV-1_LightChain 2809 10451, 18093, 25735, 33377, 41019, 48661, 56303 anti-HIV-1_LightChain 2810 10452, 18094, 25736, 33378, 41020, 48662, 56304 anti-HIV-1_LightChain 2811 10453, 18095, 25737, 33379, 41021, 48663, 56305 anti-HIV-1_LightChain 2812 10454, 18096, 25738, 33380, 41022, 48664, 56306 anti-HIV-1_LightChain 2813 10455, 18097, 25739, 33381, 41023, 48665, 56307 anti-HIV-1_LightChain 2814 10456, 18098, 25740, 33382, 41024, 48666, 56308 anti-HIV-1_LightChain 2815 10457, 18099, 25741, 33383, 41025, 48667, 56309 anti-HIV-1_LightChain 2816 10458, 18100, 25742, 33384, 41026, 48668, 56310 anti-HIV-1_LightChain 2817 10459, 18101, 25743, 33385, 41027, 48669, 56311 anti-HIV-1_LightChain 2818 10460, 18102, 25744, 33386, 41028, 48670, 56312 anti-HIV-1_LightChain 2819 10461, 18103, 25745, 33387, 41029, 48671, 56313 anti-HIV-1_LightChain 2820 10462, 18104, 25746, 33388, 41030, 48672, 56314 anti-HIV-1_HeavyChain 2821 10463, 18105, 25747, 33389, 41031, 48673, 56315 anti-HIV-1_HeavyChain 2822 10464, 18106, 25748, 33390, 41032, 48674, 56316 anti-HIV-1_HeavyChain 2823 10465, 18107, 25749, 33391, 41033, 48675, 56317 anti-HIV-1_HeavyChain 2824 10466, 18108, 25750, 33392, 41034, 48676, 56318 anti-HIV-1_HeavyChain 2825 10467, 18109, 25751, 33393, 41035, 48677, 56319 anti-HIV-1_HeavyChain 2826 10468, 18110, 25752, 33394, 41036, 48678, 56320 anti-HIV-1_HeavyChain 2827 10469, 18111, 25753, 33395, 41037, 48679, 56321 anti-HIV-1_HeavyChain 2828 10470, 18112, 25754, 33396, 41038, 48680, 56322 anti-HIV-1_HeavyChain 2829 10471, 18113, 25755, 33397, 41039, 48681, 56323 anti-HIV-1_HeavyChain 2830 10472, 18114, 25756, 33398, 41040, 48682, 56324 anti-HIV-1_HeavyChain 2831 10473, 18115, 25757, 33399, 41041, 48683, 56325 anti-HIV-1_HeavyChain 2832 10474, 18116, 25758, 33400, 41042, 48684, 56326 anti-HIV-1_HeavyChain 2833 10475, 18117, 25759, 33401, 41043, 48685, 56327 anti-HIV-1_HeavyChain 2834 10476, 18118, 25760, 33402, 41044, 48686, 56328 anti-HIV-1_HeavyChain 2835 10477, 18119, 25761, 33403, 41045, 48687, 56329 anti-HIV-1_HeavyChain 2836 10478, 18120, 25762, 33404, 41046, 48688, 56330 anti-HIV-1_HeavyChain 2837 10479, 18121, 25763, 33405, 41047, 48689, 56331 anti-HIV-1_HeavyChain 2838 10480, 18122, 25764, 33406, 41048, 48690, 56332 anti-HIV-1_HeavyChain 2839 10481, 18123, 25765, 33407, 41049, 48691, 56333 anti-HIV-1_HeavyChain 2840 10482, 18124, 25766, 33408, 41050, 48692, 56334 anti-HIV-1_HeavyChain 2841 10483, 18125, 25767, 33409, 41051, 48693, 56335 anti-HIV-1_HeavyChain 2842 10484, 18126, 25768, 33410, 41052, 48694, 56336 anti-HIV-1_HeavyChain 2843 10485, 18127, 25769, 33411, 41053, 48695, 56337 anti-HIV-1_HeavyChain 2844 10486, 18128, 25770, 33412, 41054, 48696, 56338 anti-HIV-1_HeavyChain 2845 10487, 18129, 25771, 33413, 41055, 48697, 56339 anti-HIV-1_HeavyChain 2846 10488, 18130, 25772, 33414, 41056, 48698, 56340 anti-HIV-1_HeavyChain 2847 10489, 18131, 25773, 33415, 41057, 48699, 56341 anti-HIV-1_LightChain 2848 10490, 18132, 25774, 33416, 41058, 48700, 56342 anti-HIV-1_HeavyChain 2849 10491, 18133, 25775, 33417, 41059, 48701, 56343 anti-HIV-1_HeavyChain 2850 10492, 18134, 25776, 33418, 41060, 48702, 56344 anti-HIV-1_HeavyChain 2851 10493, 18135, 25777, 33419, 41061, 48703, 56345 anti-HIV-1_HeavyChain 2852 10494, 18136, 25778, 33420, 41062, 48704, 56346 anti-HIV-1_HeavyChain 2853 10495, 18137, 25779, 33421, 41063, 48705, 56347 anti-HIV-1_HeavyChain 2854 10496, 18138, 25780, 33422, 41064, 48706, 56348 anti-HIV-1_HeavyChain 2855 10497, 18139, 25781, 33423, 41065, 48707, 56349 anti-HIV-1_HeavyChain 2856 10498, 18140, 25782, 33424, 41066, 48708, 56350 anti-HIV-1_HeavyChain 2857 10499, 18141, 25783, 33425, 41067, 48709, 56351 anti-HIV-1_HeavyChain 2858 10500, 18142, 25784, 33426, 41068, 48710, 56352 anti-HIV-1_HeavyChain 2859 10501, 18143, 25785, 33427, 41069, 48711, 56353 anti-HIV-1_HeavyChain 2860 10502, 18144, 25786, 33428, 41070, 48712, 56354 anti-HIV-1_HeavyChain 2861 10503, 18145, 25787, 33429, 41071, 48713, 56355 anti-HIV-1_HeavyChain 2862 10504, 18146, 25788, 33430, 41072, 48714, 56356 anti-HIV-1_HeavyChain 2863 10505, 18147, 25789, 33431, 41073, 48715, 56357 anti-HIV-1_HeavyChain 2864 10506, 18148, 25790, 33432, 41074, 48716, 56358 anti-HIV-1_HeavyChain 2865 10507, 18149, 25791, 33433, 41075, 48717, 56359 anti-HIV-1_HeavyChain 2866 10508, 18150, 25792, 33434, 41076, 48718, 56360 anti-HIV-1_HeavyChain 2867 10509, 18151, 25793, 33435, 41077, 48719, 56361 anti-HIV-1_HeavyChain 2868 10510, 18152, 25794, 33436, 41078, 48720, 56362 anti-HIV-1_HeavyChain 2869 10511, 18153, 25795, 33437, 41079, 48721, 56363 anti-HIV-1_HeavyChain 2870 10512, 18154, 25796, 33438, 41080, 48722, 56364 anti-HIV-1_HeavyChain 2871 10513, 18155, 25797, 33439, 41081, 48723, 56365 anti-HIV-1_HeavyChain 2872 10514, 18156, 25798, 33440, 41082, 48724, 56366 anti-HIV-1_HeavyChain 2873 10515, 18157, 25799, 33441, 41083, 48725, 56367 anti-HIV-1_HeavyChain 2874 10516, 18158, 25800, 33442, 41084, 48726, 56368 anti-HIV-1_HeavyChain 2875 10517, 18159, 25801, 33443, 41085, 48727, 56369 anti-HIV-1_HeavyChain 2876 10518, 18160, 25802, 33444, 41086, 48728, 56370 anti-HIV-1_HeavyChain 2877 10519, 18161, 25803, 33445, 41087, 48729, 56371 anti-HIV-1_HeavyChain 2878 10520, 18162, 25804, 33446, 41088, 48730, 56372 anti-HIV-1_HeavyChain 2879 10521, 18163, 25805, 33447, 41089, 48731, 56373 anti-HIV-1_HeavyChain 2880 10522, 18164, 25806, 33448, 41090, 48732, 56374 anti-HIV-1_HeavyChain 2881 10523, 18165, 25807, 33449, 41091, 48733, 56375 anti-HIV-1_HeavyChain 2882 10524, 18166, 25808, 33450, 41092, 48734, 56376 anti-HIV-1_HeavyChain 2883 10525, 18167, 25809, 33451, 41093, 48735, 56377 anti-HIV-1_HeavyChain 2884 10526, 18168, 25810, 33452, 41094, 48736, 56378 anti-HIV-1_HeavyChain 2885 10527, 18169, 25811, 33453, 41095, 48737, 56379 anti-HIV-1_HeavyChain 2886 10528, 18170, 25812, 33454, 41096, 48738, 56380 anti-HIV-1_HeavyChain 2887 10529, 18171, 25813, 33455, 41097, 48739, 56381 anti-HIV-1_HeavyChain 2888 10530, 18172, 25814, 33456, 41098, 48740, 56382 anti-HIV-1_HeavyChain 2889 10531, 18173, 25815, 33457, 41099, 48741, 56383 anti-HIV-1_HeavyChain 2890 10532, 18174, 25816, 33458, 41100, 48742, 56384 anti-HIV-1_HeavyChain 2891 10533, 18175, 25817, 33459, 41101, 48743, 56385 anti-HIV-1_HeavyChain 2892 10534, 18176, 25818, 33460, 41102, 48744, 56386 anti-HIV-1_HeavyChain 2893 10535, 18177, 25819, 33461, 41103, 48745, 56387 anti-HIV-1_HeavyChain 2894 10536, 18178, 25820, 33462, 41104, 48746, 56388 anti-HIV-1_HeavyChain 2895 10537, 18179, 25821, 33463, 41105, 48747, 56389 anti-HIV-1_HeavyChain 2896 10538, 18180, 25822, 33464, 41106, 48748, 56390 anti-HIV-1_HeavyChain 2897 10539, 18181, 25823, 33465, 41107, 48749, 56391 anti-HIV-1_HeavyChain 2898 10540, 18182, 25824, 33466, 41108, 48750, 56392 anti-HIV-1_HeavyChain 2899 10541, 18183, 25825, 33467, 41109, 48751, 56393 anti-HIV-1_HeavyChain 2900 10542, 18184, 25826, 33468, 41110, 48752, 56394 anti-HIV-1_HeavyChain 2901 10543, 18185, 25827, 33469, 41111, 48753, 56395 anti-HIV-1_HeavyChain 2902 10544, 18186, 25828, 33470, 41112, 48754, 56396 anti-HIV-1_HeavyChain 2903 10545, 18187, 25829, 33471, 41113, 48755, 56397 anti-HIV-1_HeavyChain 2904 10546, 18188, 25830, 33472, 41114, 48756, 56398 anti-HIV-1_HeavyChain 2905 10547, 18189, 25831, 33473, 41115, 48757, 56399 anti-HIV-1_HeavyChain 2906 10548, 18190, 25832, 33474, 41116, 48758, 56400 anti-HIV-1_HeavyChain 2907 10549, 18191, 25833, 33475, 41117, 48759, 56401 anti-HIV-1_HeavyChain 2908 10550, 18192, 25834, 33476, 41118, 48760, 56402 anti-HIV-1_HeavyChain 2909 10551, 18193, 25835, 33477, 41119, 48761, 56403 anti-HIV-1_HeavyChain 2910 10552, 18194, 25836, 33478, 41120, 48762, 56404 anti-HIV-1_HeavyChain 2911 10553, 18195, 25837, 33479, 41121, 48763, 56405 anti-HIV-1_HeavyChain 2912 10554, 18196, 25838, 33480, 41122, 48764, 56406 anti-HIV-1_HeavyChain 2913 10555, 18197, 25839, 33481, 41123, 48765, 56407 anti-HIV-1_HeavyChain 2914 10556, 18198, 25840, 33482, 41124, 48766, 56408 anti-HIV-1_HeavyChain 2915 10557, 18199, 25841, 33483, 41125, 48767, 56409 anti-HIV-1_HeavyChain 2916 10558, 18200, 25842, 33484, 41126, 48768, 56410 anti-HIV-1_HeavyChain 2917 10559, 18201, 25843, 33485, 41127, 48769, 56411 anti-HIV-1_HeavyChain 2918 10560, 18202, 25844, 33486, 41128, 48770, 56412 anti-HIV-1_HeavyChain 2919 10561, 18203, 25845, 33487, 41129, 48771, 56413 anti-HIV-1_HeavyChain 2920 10562, 18204, 25846, 33488, 41130, 48772, 56414 anti-HIV-1_HeavyChain 2921 10563, 18205, 25847, 33489, 41131, 48773, 56415 anti-HIV-1_HeavyChain 2922 10564, 18206, 25848, 33490, 41132, 48774, 56416 anti-HIV-1_HeavyChain 2923 10565, 18207, 25849, 33491, 41133, 48775, 56417 anti-HIV-1_HeavyChain 2924 10566, 18208, 25850, 33492, 41134, 48776, 56418 anti-HIV-1_HeavyChain 2925 10567, 18209, 25851, 33493, 41135, 48777, 56419 anti-HIV-1_HeavyChain 2926 10568, 18210, 25852, 33494, 41136, 48778, 56420 anti-HIV-1_HeavyChain 2927 10569, 18211, 25853, 33495, 41137, 48779, 56421 anti-HIV-1_HeavyChain 2928 10570, 18212, 25854, 33496, 41138, 48780, 56422 anti-HIV-1_HeavyChain 2929 10571, 18213, 25855, 33497, 41139, 48781, 56423 anti-HIV-1_HeavyChain 2930 10572, 18214, 25856, 33498, 41140, 48782, 56424 anti-HIV-1_HeavyChain 2931 10573, 18215, 25857, 33499, 41141, 48783, 56425 anti-HIV-1_HeavyChain 2932 10574, 18216, 25858, 33500, 41142, 48784, 56426 anti-HIV-1_HeavyChain 2933 10575, 18217, 25859, 33501, 41143, 48785, 56427 anti-HIV-1_HeavyChain 2934 10576, 18218, 25860, 33502, 41144, 48786, 56428 anti-HIV-1_HeavyChain 2935 10577, 18219, 25861, 33503, 41145, 48787, 56429 anti-HIV-1_HeavyChain 2936 10578, 18220, 25862, 33504, 41146, 48788, 56430 anti-HIV-1_HeavyChain 2937 10579, 18221, 25863, 33505, 41147, 48789, 56431 anti-HIV-1_HeavyChain 2938 10580, 18222, 25864, 33506, 41148, 48790, 56432 anti-HIV-1_HeavyChain 2939 10581, 18223, 25865, 33507, 41149, 48791, 56433 anti-HIV-1_HeavyChain 2940 10582, 18224, 25866, 33508, 41150, 48792, 56434 anti-HIV-1_HeavyChain 2941 10583, 18225, 25867, 33509, 41151, 48793, 56435 anti-HIV-1_HeavyChain 2942 10584, 18226, 25868, 33510, 41152, 48794, 56436 anti-HIV-1_HeavyChain 2943 10585, 18227, 25869, 33511, 41153, 48795, 56437 anti-HIV-1_HeavyChain 2944 10586, 18228, 25870, 33512, 41154, 48796, 56438 anti-HIV-1_HeavyChain 2945 10587, 18229, 25871, 33513, 41155, 48797, 56439 anti-HIV-1_HeavyChain 2946 10588, 18230, 25872, 33514, 41156, 48798, 56440 anti-HIV-1_HeavyChain 2947 10589, 18231, 25873, 33515, 41157, 48799, 56441 anti-HIV-1_HeavyChain 2948 10590, 18232, 25874, 33516, 41158, 48800, 56442 anti-HIV-1_HeavyChain 2949 10591, 18233, 25875, 33517, 41159, 48801, 56443 anti-HIV-1_HeavyChain 2950 10592, 18234, 25876, 33518, 41160, 48802, 56444 anti-HIV-1_HeavyChain 2951 10593, 18235, 25877, 33519, 41161, 48803, 56445 anti-HIV-1_HeavyChain 2952 10594, 18236, 25878, 33520, 41162, 48804, 56446 anti-HIV-1_HeavyChain 2953 10595, 18237, 25879, 33521, 41163, 48805, 56447 anti-HIV-1_HeavyChain 2954 10596, 18238, 25880, 33522, 41164, 48806, 56448 anti-HIV-1_HeavyChain 2955 10597, 18239, 25881, 33523, 41165, 48807, 56449 anti-HIV-1_HeavyChain 2956 10598, 18240, 25882, 33524, 41166, 48808, 56450 anti-HIV-1_HeavyChain 2957 10599, 18241, 25883, 33525, 41167, 48809, 56451 anti-HIV-1_HeavyChain 2958 10600, 18242, 25884, 33526, 41168, 48810, 56452 anti-HIV-1_HeavyChain 2959 10601, 18243, 25885, 33527, 41169, 48811, 56453 anti-HIV-1_HeavyChain 2960 10602, 18244, 25886, 33528, 41170, 48812, 56454 anti-HIV-1_HeavyChain 2961 10603, 18245, 25887, 33529, 41171, 48813, 56455 anti-HIV-1_HeavyChain 2962 10604, 18246, 25888, 33530, 41172, 48814, 56456 anti-HIV-1_HeavyChain 2963 10605, 18247, 25889, 33531, 41173, 48815, 56457 anti-HIV-1_HeavyChain 2964 10606, 18248, 25890, 33532, 41174, 48816, 56458 anti-HIV-1_HeavyChain 2965 10607, 18249, 25891, 33533, 41175, 48817, 56459 anti-HIV-1_HeavyChain 2966 10608, 18250, 25892, 33534, 41176, 48818, 56460 anti-HIV-1_HeavyChain 2967 10609, 18251, 25893, 33535, 41177, 48819, 56461 anti-HIV-1_HeavyChain 2968 10610, 18252, 25894, 33536, 41178, 48820, 56462 anti-HIV-1_HeavyChain 2969 10611, 18253, 25895, 33537, 41179, 48821, 56463 anti-HIV-1_HeavyChain 2970 10612, 18254, 25896, 33538, 41180, 48822, 56464 anti-HIV-1_HeavyChain 2971 10613, 18255, 25897, 33539, 41181, 48823, 56465 anti-HIV-1_HeavyChain 2972 10614, 18256, 25898, 33540, 41182, 48824, 56466 anti-HIV-1_HeavyChain 2973 10615, 18257, 25899, 33541, 41183, 48825, 56467 anti-HIV-1_HeavyChain 2974 10616, 18258, 25900, 33542, 41184, 48826, 56468 anti-HIV-1_HeavyChain 2975 10617, 18259, 25901, 33543, 41185, 48827, 56469 anti-HIV-1_HeavyChain 2976 10618, 18260, 25902, 33544, 41186, 48828, 56470 anti-HIV-1_HeavyChain 2977 10619, 18261, 25903, 33545, 41187, 48829, 56471 anti-HIV-1_HeavyChain 2978 10620, 18262, 25904, 33546, 41188, 48830, 56472 anti-HIV-1_HeavyChain 2979 10621, 18263, 25905, 33547, 41189, 48831, 56473 anti-HIV-1_HeavyChain 2980 10622, 18264, 25906, 33548, 41190, 48832, 56474 anti-HIV-1_HeavyChain 2981 10623, 18265, 25907, 33549, 41191, 48833, 56475 anti-HIV-1_HeavyChain 2982 10624, 18266, 25908, 33550, 41192, 48834, 56476 anti-HIV-1_HeavyChain 2983 10625, 18267, 25909, 33551, 41193, 48835, 56477 anti-HIV-1_HeavyChain 2984 10626, 18268, 25910, 33552, 41194, 48836, 56478 anti-HIV-1_HeavyChain 2985 10627, 18269, 25911, 33553, 41195, 48837, 56479 anti-HIV-1_HeavyChain 2986 10628, 18270, 25912, 33554, 41196, 48838, 56480 anti-HIV-1_HeavyChain 2987 10629, 18271, 25913, 33555, 41197, 48839, 56481 anti-HIV-1_HeavyChain 2988 10630, 18272, 25914, 33556, 41198, 48840, 56482 anti-HIV-1_HeavyChain 2989 10631, 18273, 25915, 33557, 41199, 48841, 56483 anti-HIV-1_HeavyChain 2990 10632, 18274, 25916, 33558, 41200, 48842, 56484 anti-HIV-1_HeavyChain 2991 10633, 18275, 25917, 33559, 41201, 48843, 56485 anti-HIV-1_HeavyChain 2992 10634, 18276, 25918, 33560, 41202, 48844, 56486 anti-HIV-1_HeavyChain 2993 10635, 18277, 25919, 33561, 41203, 48845, 56487 anti-HIV-1_HeavyChain 2994 10636, 18278, 25920, 33562, 41204, 48846, 56488 anti-HIV-1_HeavyChain 2995 10637, 18279, 25921, 33563, 41205, 48847, 56489 anti-HIV-1_HeavyChain 2996 10638, 18280, 25922, 33564, 41206, 48848, 56490 anti-HIV-1_HeavyChain 2997 10639, 18281, 25923, 33565, 41207, 48849, 56491 anti-HIV-1_HeavyChain 2998 10640, 18282, 25924, 33566, 41208, 48850, 56492 anti-HIV-1_HeavyChain 2999 10641, 18283, 25925, 33567, 41209, 48851, 56493 anti-HIV-1_HeavyChain 3000 10642, 18284, 25926, 33568, 41210, 48852, 56494 anti-HIV-1_HeavyChain 3001 10643, 18285, 25927, 33569, 41211, 48853, 56495 anti-HIV-1_HeavyChain 3002 10644, 18286, 25928, 33570, 41212, 48854, 56496 anti-HIV-1_HeavyChain 3003 10645, 18287, 25929, 33571, 41213, 48855, 56497 anti-HIV-1_HeavyChain 3004 10646, 18288, 25930, 33572, 41214, 48856, 56498 anti-HIV-1_HeavyChain 3005 10647, 18289, 25931, 33573, 41215, 48857, 56499 anti-HIV-1_HeavyChain 3006 10648, 18290, 25932, 33574, 41216, 48858, 56500 anti-HIV-1_HeavyChain 3007 10649, 18291, 25933, 33575, 41217, 48859, 56501 anti-HIV-1_HeavyChain 3008 10650, 18292, 25934, 33576, 41218, 48860, 56502 anti-HIV-1_HeavyChain 3009 10651, 18293, 25935, 33577, 41219, 48861, 56503 anti-HIV-1_HeavyChain 3010 10652, 18294, 25936, 33578, 41220, 48862, 56504 anti-HIV-1_HeavyChain 3011 10653, 18295, 25937, 33579, 41221, 48863, 56505 anti-HIV-1_HeavyChain 3012 10654, 18296, 25938, 33580, 41222, 48864, 56506 anti-HIV-1_HeavyChain 3013 10655, 18297, 25939, 33581, 41223, 48865, 56507 anti-HIV-1_HeavyChain 3014 10656, 18298, 25940, 33582, 41224, 48866, 56508 anti-HIV-1_HeavyChain 3015 10657, 18299, 25941, 33583, 41225, 48867, 56509 anti-HIV-1_HeavyChain 3016 10658, 18300, 25942, 33584, 41226, 48868, 56510 anti-HIV-1_HeavyChain 3017 10659, 18301, 25943, 33585, 41227, 48869, 56511 anti-HIV-1_HeavyChain 3018 10660, 18302, 25944, 33586, 41228, 48870, 56512 anti-HIV-1_HeavyChain 3019 10661, 18303, 25945, 33587, 41229, 48871, 56513 anti-HIV-1_HeavyChain 3020 10662, 18304, 25946, 33588, 41230, 48872, 56514 anti-HIV-1_HeavyChain 3021 10663, 18305, 25947, 33589, 41231, 48873, 56515 anti-HIV-1_HeavyChain 3022 10664, 18306, 25948, 33590, 41232, 48874, 56516 anti-HIV-1_HeavyChain 3023 10665, 18307, 25949, 33591, 41233, 48875, 56517 anti-HIV-1_HeavyChain 3024 10666, 18308, 25950, 33592, 41234, 48876, 56518 anti-HIV-1_HeavyChain 3025 10667, 18309, 25951, 33593, 41235, 48877, 56519 anti-HIV-1_HeavyChain 3026 10668, 18310, 25952, 33594, 41236, 48878, 56520 anti-HIV-1_HeavyChain 3027 10669, 18311, 25953, 33595, 41237, 48879, 56521 anti-HIV-1_HeavyChain 3028 10670, 18312, 25954, 33596, 41238, 48880, 56522 anti-HIV-1_HeavyChain 3029 10671, 18313, 25955, 33597, 41239, 48881, 56523 anti-HIV-1_HeavyChain 3030 10672, 18314, 25956, 33598, 41240, 48882, 56524 anti-HIV-1_HeavyChain 3031 10673, 18315, 25957, 33599, 41241, 48883, 56525 anti-HIV-1_HeavyChain 3032 10674, 18316, 25958, 33600, 41242, 48884, 56526 anti-HIV-1_HeavyChain 3033 10675, 18317, 25959, 33601, 41243, 48885, 56527 anti-HIV-1_HeavyChain 3034 10676, 18318, 25960, 33602, 41244, 48886, 56528 anti-HIV-1_HeavyChain 3035 10677, 18319, 25961, 33603, 41245, 48887, 56529 anti-HIV-1_HeavyChain 3036 10678, 18320, 25962, 33604, 41246, 48888, 56530 anti-HIV-1_HeavyChain 3037 10679, 18321, 25963, 33605, 41247, 48889, 56531 anti-HIV-1_HeavyChain 3038 10680, 18322, 25964, 33606, 41248, 48890, 56532 anti-HIV-1_HeavyChain 3039 10681, 18323, 25965, 33607, 41249, 48891, 56533 anti-HIV-1_HeavyChain 3040 10682, 18324, 25966, 33608, 41250, 48892, 56534 anti-HIV-1_HeavyChain 3041 10683, 18325, 25967, 33609, 41251, 48893, 56535 anti-HIV-1_HeavyChain 3042 10684, 18326, 25968, 33610, 41252, 48894, 56536 anti-HIV-1_HeavyChain 3043 10685, 18327, 25969, 33611, 41253, 48895, 56537 anti-HIV-1_HeavyChain 3044 10686, 18328, 25970, 33612, 41254, 48896, 56538 anti-HIV-1_HeavyChain 3045 10687, 18329, 25971, 33613, 41255, 48897, 56539 anti-HIV-1_HeavyChain 3046 10688, 18330, 25972, 33614, 41256, 48898, 56540 anti-HIV-1_HeavyChain 3047 10689, 18331, 25973, 33615, 41257, 48899, 56541 anti-HIV-1_HeavyChain 3048 10690, 18332, 25974, 33616, 41258, 48900, 56542 anti-HIV-1_HeavyChain 3049 10691, 18333, 25975, 33617, 41259, 48901, 56543 anti-HIV-1_HeavyChain 3050 10692, 18334, 25976, 33618, 41260, 48902, 56544 anti-HIV-1_HeavyChain 3051 10693, 18335, 25977, 33619, 41261, 48903, 56545 anti-HIV-1_HeavyChain 3052 10694, 18336, 25978, 33620, 41262, 48904, 56546 anti-HIV-1_HeavyChain 3053 10695, 18337, 25979, 33621, 41263, 48905, 56547 anti-HIV-1_HeavyChain 3054 10696, 18338, 25980, 33622, 41264, 48906, 56548 anti-HIV-1_HeavyChain 3055 10697, 18339, 25981, 33623, 41265, 48907, 56549 anti-HIV-1_HeavyChain 3056 10698, 18340, 25982, 33624, 41266, 48908, 56550 anti-HIV-1_HeavyChain 3057 10699, 18341, 25983, 33625, 41267, 48909, 56551 anti-HIV-1_HeavyChain 3058 10700, 18342, 25984, 33626, 41268, 48910, 56552 anti-HIV-1_HeavyChain 3059 10701, 18343, 25985, 33627, 41269, 48911, 56553 anti-HIV-1_HeavyChain 3060 10702, 18344, 25986, 33628, 41270, 48912, 56554 anti-HIV-1_HeavyChain 3061 10703, 18345, 25987, 33629, 41271, 48913, 56555 anti-HIV-1_HeavyChain 3062 10704, 18346, 25988, 33630, 41272, 48914, 56556 anti-HIV-1_HeavyChain 3063 10705, 18347, 25989, 33631, 41273, 48915, 56557 anti-HIV-1_HeavyChain 3064 10706, 18348, 25990, 33632, 41274, 48916, 56558 anti-HIV-1_HeavyChain 3065 10707, 18349, 25991, 33633, 41275, 48917, 56559 anti-HIV-1_HeavyChain 3066 10708, 18350, 25992, 33634, 41276, 48918, 56560 anti-HIV-1_HeavyChain 3067 10709, 18351, 25993, 33635, 41277, 48919, 56561 anti-HIV-1_HeavyChain 3068 10710, 18352, 25994, 33636, 41278, 48920, 56562 anti-HIV-1_HeavyChain 3069 10711, 18353, 25995, 33637, 41279, 48921, 56563 anti-HIV-1_HeavyChain 3070 10712, 18354, 25996, 33638, 41280, 48922, 56564 anti-HIV-1_HeavyChain 3071 10713, 18355, 25997, 33639, 41281, 48923, 56565 anti-HIV-1_HeavyChain 3072 10714, 18356, 25998, 33640, 41282, 48924, 56566 anti-HIV-1_HeavyChain 3073 10715, 18357, 25999, 33641, 41283, 48925, 56567 anti-HIV-1_HeavyChain 3074 10716, 18358, 26000, 33642, 41284, 48926, 56568 anti-HIV-1_HeavyChain 3075 10717, 18359, 26001, 33643, 41285, 48927, 56569 anti-HIV-1_HeavyChain 3076 10718, 18360, 26002, 33644, 41286, 48928, 56570 anti-HIV-1_HeavyChain 3077 10719, 18361, 26003, 33645, 41287, 48929, 56571 anti-HIV-1_HeavyChain 3078 10720, 18362, 26004, 33646, 41288, 48930, 56572 anti-HIV-1_HeavyChain 3079 10721, 18363, 26005, 33647, 41289, 48931, 56573 anti-HIV-1_HeavyChain 3080 10722, 18364, 26006, 33648, 41290, 48932, 56574 anti-HIV-1_HeavyChain 3081 10723, 18365, 26007, 33649, 41291, 48933, 56575 anti-HIV-1_HeavyChain 3082 10724, 18366, 26008, 33650, 41292, 48934, 56576 anti-HIV-1_HeavyChain 3083 10725, 18367, 26009, 33651, 41293, 48935, 56577 anti-HIV-1_HeavyChain 3084 10726, 18368, 26010, 33652, 41294, 48936, 56578 anti-HIV-1_HeavyChain 3085 10727, 18369, 26011, 33653, 41295, 48937, 56579 anti-HIV-1_HeavyChain 3086 10728, 18370, 26012, 33654, 41296, 48938, 56580 anti-HIV-1_HeavyChain 3087 10729, 18371, 26013, 33655, 41297, 48939, 56581 anti-HIV-1_HeavyChain 3088 10730, 18372, 26014, 33656, 41298, 48940, 56582 anti-HIV-1_HeavyChain 3089 10731, 18373, 26015, 33657, 41299, 48941, 56583 anti-HIV-1_HeavyChain 3090 10732, 18374, 26016, 33658, 41300, 48942, 56584 anti-HIV-1_HeavyChain 3091 10733, 18375, 26017, 33659, 41301, 48943, 56585 anti-HIV-1_HeavyChain 3092 10734, 18376, 26018, 33660, 41302, 48944, 56586 anti-HIV-1_HeavyChain 3093 10735, 18377, 26019, 33661, 41303, 48945, 56587 anti-HIV-1_HeavyChain 3094 10736, 18378, 26020, 33662, 41304, 48946, 56588 anti-HIV-1_HeavyChain 3095 10737, 18379, 26021, 33663, 41305, 48947, 56589 anti-HIV-1_HeavyChain 3096 10738, 18380, 26022, 33664, 41306, 48948, 56590 anti-HIV-1_HeavyChain 3097 10739, 18381, 26023, 33665, 41307, 48949, 56591 anti-HIV-1_HeavyChain 3098 10740, 18382, 26024, 33666, 41308, 48950, 56592 anti-HIV-1_HeavyChain 3099 10741, 18383, 26025, 33667, 41309, 48951, 56593 anti-HIV-1_HeavyChain 3100 10742, 18384, 26026, 33668, 41310, 48952, 56594 anti-HIV-1_HeavyChain 3101 10743, 18385, 26027, 33669, 41311, 48953, 56595 anti-HIV-1_HeavyChain 3102 10744, 18386, 26028, 33670, 41312, 48954, 56596 anti-HIV-1_HeavyChain 3103 10745, 18387, 26029, 33671, 41313, 48955, 56597 anti-HIV-1_HeavyChain 3104 10746, 18388, 26030, 33672, 41314, 48956, 56598 anti-HIV-1_HeavyChain 3105 10747, 18389, 26031, 33673, 41315, 48957, 56599 anti-HIV-1_HeavyChain 3106 10748, 18390, 26032, 33674, 41316, 48958, 56600 anti-HIV-1_HeavyChain 3107 10749, 18391, 26033, 33675, 41317, 48959, 56601 anti-HIV-1_HeavyChain 3108 10750, 18392, 26034, 33676, 41318, 48960, 56602 anti-HIV-1_HeavyChain 3109 10751, 18393, 26035, 33677, 41319, 48961, 56603 anti-HIV-1_HeavyChain 3110 10752, 18394, 26036, 33678, 41320, 48962, 56604 anti-HIV-1_HeavyChain 3111 10753, 18395, 26037, 33679, 41321, 48963, 56605 anti-HIV-1_HeavyChain 3112 10754, 18396, 26038, 33680, 41322, 48964, 56606 anti-HIV-1_HeavyChain 3113 10755, 18397, 26039, 33681, 41323, 48965, 56607 anti-HIV-1_HeavyChain 3114 10756, 18398, 26040, 33682, 41324, 48966, 56608 anti-HIV-1_HeavyChain 3115 10757, 18399, 26041, 33683, 41325, 48967, 56609 anti-HIV-1_HeavyChain 3116 10758, 18400, 26042, 33684, 41326, 48968, 56610 anti-HIV-1_HeavyChain 3117 10759, 18401, 26043, 33685, 41327, 48969, 56611 anti-HIV-1_HeavyChain 3118 10760, 18402, 26044, 33686, 41328, 48970, 56612 anti-HIV-1_HeavyChain 3119 10761, 18403, 26045, 33687, 41329, 48971, 56613 anti-HIV-1_HeavyChain 3120 10762, 18404, 26046, 33688, 41330, 48972, 56614 anti-HIV-1_HeavyChain 3121 10763, 18405, 26047, 33689, 41331, 48973, 56615 anti-HIV-1_HeavyChain 3122 10764, 18406, 26048, 33690, 41332, 48974, 56616 anti-HIV-1_HeavyChain 3123 10765, 18407, 26049, 33691, 41333, 48975, 56617 anti-HIV-1_HeavyChain 3124 10766, 18408, 26050, 33692, 41334, 48976, 56618 anti-HIV-1_HeavyChain 3125 10767, 18409, 26051, 33693, 41335, 48977, 56619 anti-HIV-1_HeavyChain 3126 10768, 18410, 26052, 33694, 41336, 48978, 56620 anti-HIV-1_HeavyChain 3127 10769, 18411, 26053, 33695, 41337, 48979, 56621 anti-HIV-1_HeavyChain 3128 10770, 18412, 26054, 33696, 41338, 48980, 56622 anti-HIV-1_HeavyChain 3129 10771, 18413, 26055, 33697, 41339, 48981, 56623 anti-HIV-1_HeavyChain 3130 10772, 18414, 26056, 33698, 41340, 48982, 56624 anti-HIV-1_HeavyChain 3131 10773, 18415, 26057, 33699, 41341, 48983, 56625 anti-HIV-1_HeavyChain 3132 10774, 18416, 26058, 33700, 41342, 48984, 56626 anti-HIV-1_HeavyChain 3133 10775, 18417, 26059, 33701, 41343, 48985, 56627 anti-HIV-1_HeavyChain 3134 10776, 18418, 26060, 33702, 41344, 48986, 56628 anti-HIV-1_HeavyChain 3135 10777, 18419, 26061, 33703, 41345, 48987, 56629 anti-HIV-1_HeavyChain 3136 10778, 18420, 26062, 33704, 41346, 48988, 56630 anti-HIV-1_HeavyChain 3137 10779, 18421, 26063, 33705, 41347, 48989, 56631 anti-HIV-1_HeavyChain 3138 10780, 18422, 26064, 33706, 41348, 48990, 56632 anti-HIV-1_HeavyChain 3139 10781, 18423, 26065, 33707, 41349, 48991, 56633 anti-HIV-1_HeavyChain 3140 10782, 18424, 26066, 33708, 41350, 48992, 56634 anti-HIV-1_HeavyChain 3141 10783, 18425, 26067, 33709, 41351, 48993, 56635 anti-HIV-1_HeavyChain 3142 10784, 18426, 26068, 33710, 41352, 48994, 56636 anti-HIV-1_HeavyChain 3143 10785, 18427, 26069, 33711, 41353, 48995, 56637 anti-HIV-1_HeavyChain 3144 10786, 18428, 26070, 33712, 41354, 48996, 56638 anti-HIV-1_HeavyChain 3145 10787, 18429, 26071, 33713, 41355, 48997, 56639 anti-HIV-1_HeavyChain 3146 10788, 18430, 26072, 33714, 41356, 48998, 56640 anti-HIV-1_HeavyChain 3147 10789, 18431, 26073, 33715, 41357, 48999, 56641 anti-HIV-1_HeavyChain 3148 10790, 18432, 26074, 33716, 41358, 49000, 56642 anti-HIV-1_HeavyChain 3149 10791, 18433, 26075, 33717, 41359, 49001, 56643 anti-HIV-1_HeavyChain 3150 10792, 18434, 26076, 33718, 41360, 49002, 56644 anti-HIV-1_HeavyChain 3151 10793, 18435, 26077, 33719, 41361, 49003, 56645 anti-HIV-1_HeavyChain 3152 10794, 18436, 26078, 33720, 41362, 49004, 56646 anti-HIV-1_HeavyChain 3153 10795, 18437, 26079, 33721, 41363, 49005, 56647 anti-HIV-1_HeavyChain 3154 10796, 18438, 26080, 33722, 41364, 49006, 56648 anti-HIV-1_HeavyChain 3155 10797, 18439, 26081, 33723, 41365, 49007, 56649 anti-HIV-1_HeavyChain 3156 10798, 18440, 26082, 33724, 41366, 49008, 56650 anti-HIV-1_HeavyChain 3157 10799, 18441, 26083, 33725, 41367, 49009, 56651 anti-HIV-1_HeavyChain 3158 10800, 18442, 26084, 33726, 41368, 49010, 56652 anti-HIV-1_HeavyChain 3159 10801, 18443, 26085, 33727, 41369, 49011, 56653 anti-HIV-1_HeavyChain 3160 10802, 18444, 26086, 33728, 41370, 49012, 56654 anti-HIV-1_HeavyChain 3161 10803, 18445, 26087, 33729, 41371, 49013, 56655 anti-HIV-1_HeavyChain 3162 10804, 18446, 26088, 33730, 41372, 49014, 56656 anti-HIV-1_HeavyChain 3163 10805, 18447, 26089, 33731, 41373, 49015, 56657 anti-HIV-1_HeavyChain 3164 10806, 18448, 26090, 33732, 41374, 49016, 56658 anti-HIV-1_HeavyChain 3165 10807, 18449, 26091, 33733, 41375, 49017, 56659 anti-HIV-1_HeavyChain 3166 10808, 18450, 26092, 33734, 41376, 49018, 56660 anti-HIV-1_HeavyChain 3167 10809, 18451, 26093, 33735, 41377, 49019, 56661 anti-HIV-1_HeavyChain 3168 10810, 18452, 26094, 33736, 41378, 49020, 56662 anti-HIV-1_HeavyChain 3169 10811, 18453, 26095, 33737, 41379, 49021, 56663 anti-HIV-1_HeavyChain 3170 10812, 18454, 26096, 33738, 41380, 49022, 56664 anti-HIV-1_HeavyChain 3171 10813, 18455, 26097, 33739, 41381, 49023, 56665 anti-HIV-1_HeavyChain 3172 10814, 18456, 26098, 33740, 41382, 49024, 56666 anti-HIV-1_HeavyChain 3173 10815, 18457, 26099, 33741, 41383, 49025, 56667 anti-HIV-1_HeavyChain 3174 10816, 18458, 26100, 33742, 41384, 49026, 56668 anti-HIV-1_HeavyChain 3175 10817, 18459, 26101, 33743, 41385, 49027, 56669 anti-HIV-1_HeavyChain 3176 10818, 18460, 26102, 33744, 41386, 49028, 56670 anti-HIV-1_HeavyChain 3177 10819, 18461, 26103, 33745, 41387, 49029, 56671 anti-HIV-1_HeavyChain 3178 10820, 18462, 26104, 33746, 41388, 49030, 56672 anti-HIV-1_HeavyChain 3179 10821, 18463, 26105, 33747, 41389, 49031, 56673 anti-HIV-1_HeavyChain 3180 10822, 18464, 26106, 33748, 41390, 49032, 56674 anti-HIV-1_HeavyChain 3181 10823, 18465, 26107, 33749, 41391, 49033, 56675 anti-HIV-1_HeavyChain 3182 10824, 18466, 26108, 33750, 41392, 49034, 56676 anti-HIV-1_HeavyChain 3183 10825, 18467, 26109, 33751, 41393, 49035, 56677 anti-HIV-1_HeavyChain 3184 10826, 18468, 26110, 33752, 41394, 49036, 56678 anti-HIV-1_HeavyChain 3185 10827, 18469, 26111, 33753, 41395, 49037, 56679 anti-HIV-1_HeavyChain 3186 10828, 18470, 26112, 33754, 41396, 49038, 56680 anti-HIV-1_HeavyChain 3187 10829, 18471, 26113, 33755, 41397, 49039, 56681 anti-HIV-1_HeavyChain 3188 10830, 18472, 26114, 33756, 41398, 49040, 56682 anti-HIV-1_HeavyChain 3189 10831, 18473, 26115, 33757, 41399, 49041, 56683 anti-HIV-1_HeavyChain 3190 10832, 18474, 26116, 33758, 41400, 49042, 56684 anti-HIV-1_HeavyChain 3191 10833, 18475, 26117, 33759, 41401, 49043, 56685 anti-HIV-1_HeavyChain 3192 10834, 18476, 26118, 33760, 41402, 49044, 56686 anti-HIV-1_HeavyChain 3193 10835, 18477, 26119, 33761, 41403, 49045, 56687 anti-HIV-1_HeavyChain 3194 10836, 18478, 26120, 33762, 41404, 49046, 56688 anti-HIV-1_HeavyChain 3195 10837, 18479, 26121, 33763, 41405, 49047, 56689 anti-HIV-1_HeavyChain 3196 10838, 18480, 26122, 33764, 41406, 49048, 56690 anti-HIV-1_HeavyChain 3197 10839, 18481, 26123, 33765, 41407, 49049, 56691 anti-HIV-1_HeavyChain 3198 10840, 18482, 26124, 33766, 41408, 49050, 56692 anti-HIV-1_HeavyChain 3199 10841, 18483, 26125, 33767, 41409, 49051, 56693 anti-HIV-1_HeavyChain 3200 10842, 18484, 26126, 33768, 41410, 49052, 56694 anti-HIV-1_HeavyChain 3201 10843, 18485, 26127, 33769, 41411, 49053, 56695 anti-HIV-1_HeavyChain 3202 10844, 18486, 26128, 33770, 41412, 49054, 56696 anti-HIV-1_HeavyChain 3203 10845, 18487, 26129, 33771, 41413, 49055, 56697 anti-HIV-1_HeavyChain 3204 10846, 18488, 26130, 33772, 41414, 49056, 56698 anti-HIV-1_HeavyChain 3205 10847, 18489, 26131, 33773, 41415, 49057, 56699 anti-HIV-1_HeavyChain 3206 10848, 18490, 26132, 33774, 41416, 49058, 56700 anti-HIV-1_HeavyChain 3207 10849, 18491, 26133, 33775, 41417, 49059, 56701 anti-HIV-1_HeavyChain 3208 10850, 18492, 26134, 33776, 41418, 49060, 56702 anti-HIV-1_HeavyChain 3209 10851, 18493, 26135, 33777, 41419, 49061, 56703 anti-HIV-1_HeavyChain 3210 10852, 18494, 26136, 33778, 41420, 49062, 56704 anti-HIV-1_HeavyChain 3211 10853, 18495, 26137, 33779, 41421, 49063, 56705 anti-HIV-1_HeavyChain 3212 10854, 18496, 26138, 33780, 41422, 49064, 56706 anti-HIV-1_HeavyChain 3213 10855, 18497, 26139, 33781, 41423, 49065, 56707 anti-HIV-1_HeavyChain 3214 10856, 18498, 26140, 33782, 41424, 49066, 56708 anti-HIV-1_HeavyChain 3215 10857, 18499, 26141, 33783, 41425, 49067, 56709 anti-HIV-1_HeavyChain 3216 10858, 18500, 26142, 33784, 41426, 49068, 56710 anti-HIV-1_HeavyChain 3217 10859, 18501, 26143, 33785, 41427, 49069, 56711 anti-HIV-1_HeavyChain 3218 10860, 18502, 26144, 33786, 41428, 49070, 56712 anti-HIV-1_HeavyChain 3219 10861, 18503, 26145, 33787, 41429, 49071, 56713 anti-HIV-1_HeavyChain 3220 10862, 18504, 26146, 33788, 41430, 49072, 56714 anti-HIV-1_HeavyChain 3221 10863, 18505, 26147, 33789, 41431, 49073, 56715 anti-HIV-1_HeavyChain 3222 10864, 18506, 26148, 33790, 41432, 49074, 56716 anti-HIV-1_HeavyChain 3223 10865, 18507, 26149, 33791, 41433, 49075, 56717 anti-HIV-1_HeavyChain 3224 10866, 18508, 26150, 33792, 41434, 49076, 56718 anti-HIV-1_HeavyChain 3225 10867, 18509, 26151, 33793, 41435, 49077, 56719 anti-HIV-1_HeavyChain 3226 10868, 18510, 26152, 33794, 41436, 49078, 56720 anti-HIV-1_HeavyChain 3227 10869, 18511, 26153, 33795, 41437, 49079, 56721 anti-HIV-1_HeavyChain 3228 10870, 18512, 26154, 33796, 41438, 49080, 56722 anti-HIV-1_HeavyChain 3229 10871, 18513, 26155, 33797, 41439, 49081, 56723 anti-HIV-1_HeavyChain 3230 10872, 18514, 26156, 33798, 41440, 49082, 56724 anti-HIV-1_HeavyChain 3231 10873, 18515, 26157, 33799, 41441, 49083, 56725 anti-HIV-1_HeavyChain 3232 10874, 18516, 26158, 33800, 41442, 49084, 56726 anti-HIV-1_HeavyChain 3233 10875, 18517, 26159, 33801, 41443, 49085, 56727 anti-HIV-1_HeavyChain 3234 10876, 18518, 26160, 33802, 41444, 49086, 56728 anti-HIV-1_HeavyChain 3235 10877, 18519, 26161, 33803, 41445, 49087, 56729 anti-HIV-1_HeavyChain 3236 10878, 18520, 26162, 33804, 41446, 49088, 56730 anti-HIV-1_HeavyChain 3237 10879, 18521, 26163, 33805, 41447, 49089, 56731 anti-HIV-1_HeavyChain 3238 10880, 18522, 26164, 33806, 41448, 49090, 56732 anti-HIV-1_HeavyChain 3239 10881, 18523, 26165, 33807, 41449, 49091, 56733 anti-HIV-1_HeavyChain 3240 10882, 18524, 26166, 33808, 41450, 49092, 56734 anti-HIV-1_HeavyChain 3241 10883, 18525, 26167, 33809, 41451, 49093, 56735 anti-HIV-1_HeavyChain 3242 10884, 18526, 26168, 33810, 41452, 49094, 56736 anti-HIV-1_HeavyChain 3243 10885, 18527, 26169, 33811, 41453, 49095, 56737 anti-HIV-1_HeavyChain 3244 10886, 18528, 26170, 33812, 41454, 49096, 56738 anti-HIV-1_HeavyChain 3245 10887, 18529, 26171, 33813, 41455, 49097, 56739 anti-HIV-1_HeavyChain 3246 10888, 18530, 26172, 33814, 41456, 49098, 56740 anti-HIV-1_HeavyChain 3247 10889, 18531, 26173, 33815, 41457, 49099, 56741 anti-HIV-1_HeavyChain 3248 10890, 18532, 26174, 33816, 41458, 49100, 56742 anti-HIV-1_HeavyChain 3249 10891, 18533, 26175, 33817, 41459, 49101, 56743 anti-HIV-1_HeavyChain 3250 10892, 18534, 26176, 33818, 41460, 49102, 56744 anti-HIV-1_HeavyChain 3251 10893, 18535, 26177, 33819, 41461, 49103, 56745 anti-HIV-1_HeavyChain 3252 10894, 18536, 26178, 33820, 41462, 49104, 56746 anti-HIV-1_HeavyChain 3253 10895, 18537, 26179, 33821, 41463, 49105, 56747 anti-HIV-1_HeavyChain 3254 10896, 18538, 26180, 33822, 41464, 49106, 56748 anti-HIV-1_HeavyChain 3255 10897, 18539, 26181, 33823, 41465, 49107, 56749 anti-HIV-1_HeavyChain 3256 10898, 18540, 26182, 33824, 41466, 49108, 56750 anti-HIV-1_HeavyChain 3257 10899, 18541, 26183, 33825, 41467, 49109, 56751 anti-HIV-1_HeavyChain 3258 10900, 18542, 26184, 33826, 41468, 49110, 56752 anti-HIV-1_HeavyChain 3259 10901, 18543, 26185, 33827, 41469, 49111, 56753 anti-HIV-1_HeavyChain 3260 10902, 18544, 26186, 33828, 41470, 49112, 56754 anti-HIV-1_HeavyChain 3261 10903, 18545, 26187, 33829, 41471, 49113, 56755 anti-HIV-1_HeavyChain 3262 10904, 18546, 26188, 33830, 41472, 49114, 56756 anti-HIV-1_HeavyChain 3263 10905, 18547, 26189, 33831, 41473, 49115, 56757 anti-HIV-1_HeavyChain 3264 10906, 18548, 26190, 33832, 41474, 49116, 56758 anti-HIV-1_HeavyChain 3265 10907, 18549, 26191, 33833, 41475, 49117, 56759 anti-HIV-1_HeavyChain 3266 10908, 18550, 26192, 33834, 41476, 49118, 56760 anti-HIV-1_HeavyChain 3267 10909, 18551, 26193, 33835, 41477, 49119, 56761 anti-HIV-1_HeavyChain 3268 10910, 18552, 26194, 33836, 41478, 49120, 56762 anti-HIV-1_HeavyChain 3269 10911, 18553, 26195, 33837, 41479, 49121, 56763 anti-HIV-1_HeavyChain 3270 10912, 18554, 26196, 33838, 41480, 49122, 56764 anti-HIV-1_HeavyChain 3271 10913, 18555, 26197, 33839, 41481, 49123, 56765 anti-HIV-1_HeavyChain 3272 10914, 18556, 26198, 33840, 41482, 49124, 56766 anti-HIV-1_HeavyChain 3273 10915, 18557, 26199, 33841, 41483, 49125, 56767 anti-HIV-1_HeavyChain 3274 10916, 18558, 26200, 33842, 41484, 49126, 56768 anti-HIV-1_HeavyChain 3275 10917, 18559, 26201, 33843, 41485, 49127, 56769 anti-HIV-1_HeavyChain 3276 10918, 18560, 26202, 33844, 41486, 49128, 56770 anti-HIV-1_HeavyChain 3277 10919, 18561, 26203, 33845, 41487, 49129, 56771 anti-HIV-1_HeavyChain 3278 10920, 18562, 26204, 33846, 41488, 49130, 56772 anti-HIV-1_HeavyChain 3279 10921, 18563, 26205, 33847, 41489, 49131, 56773 anti-HIV-1_HeavyChain 3280 10922, 18564, 26206, 33848, 41490, 49132, 56774 anti-HIV-1_HeavyChain 3281 10923, 18565, 26207, 33849, 41491, 49133, 56775 anti-HIV-1_HeavyChain 3282 10924, 18566, 26208, 33850, 41492, 49134, 56776 anti-HIV-1_HeavyChain 3283 10925, 18567, 26209, 33851, 41493, 49135, 56777 anti-HIV-1_HeavyChain 3284 10926, 18568, 26210, 33852, 41494, 49136, 56778 anti-HIV-1_HeavyChain 3285 10927, 18569, 26211, 33853, 41495, 49137, 56779 anti-HIV-1_HeavyChain 3286 10928, 18570, 26212, 33854, 41496, 49138, 56780 anti-HIV-1_HeavyChain 3287 10929, 18571, 26213, 33855, 41497, 49139, 56781 anti-HIV-1_HeavyChain 3288 10930, 18572, 26214, 33856, 41498, 49140, 56782 anti-HIV-1_HeavyChain 3289 10931, 18573, 26215, 33857, 41499, 49141, 56783 anti-HIV-1_HeavyChain 3290 10932, 18574, 26216, 33858, 41500, 49142, 56784 anti-HIV-1_HeavyChain 3291 10933, 18575, 26217, 33859, 41501, 49143, 56785 anti-HIV-1_HeavyChain 3292 10934, 18576, 26218, 33860, 41502, 49144, 56786 anti-HIV-1_HeavyChain 3293 10935, 18577, 26219, 33861, 41503, 49145, 56787 anti-HIV-1_HeavyChain 3294 10936, 18578, 26220, 33862, 41504, 49146, 56788 anti-HIV-1_HeavyChain 3295 10937, 18579, 26221, 33863, 41505, 49147, 56789 anti-HIV-1_HeavyChain 3296 10938, 18580, 26222, 33864, 41506, 49148, 56790 anti-HIV-1_HeavyChain 3297 10939, 18581, 26223, 33865, 41507, 49149, 56791 anti-HIV-1_HeavyChain 3298 10940, 18582, 26224, 33866, 41508, 49150, 56792 anti-HIV-1_HeavyChain 3299 10941, 18583, 26225, 33867, 41509, 49151, 56793 anti-HIV-1_HeavyChain 3300 10942, 18584, 26226, 33868, 41510, 49152, 56794 anti-HIV-1_HeavyChain 3301 10943, 18585, 26227, 33869, 41511, 49153, 56795 anti-HIV-1_HeavyChain 3302 10944, 18586, 26228, 33870, 41512, 49154, 56796 anti-HIV-1_HeavyChain 3303 10945, 18587, 26229, 33871, 41513, 49155, 56797 anti-HIV-1_HeavyChain 3304 10946, 18588, 26230, 33872, 41514, 49156, 56798 anti-HIV-1_HeavyChain 3305 10947, 18589, 26231, 33873, 41515, 49157, 56799 anti-HIV-1_HeavyChain 3306 10948, 18590, 26232, 33874, 41516, 49158, 56800 anti-HIV-1_HeavyChain 3307 10949, 18591, 26233, 33875, 41517, 49159, 56801 anti-HIV-1_HeavyChain 3308 10950, 18592, 26234, 33876, 41518, 49160, 56802 anti-HIV-1_HeavyChain 3309 10951, 18593, 26235, 33877, 41519, 49161, 56803 anti-HIV-1_HeavyChain 3310 10952, 18594, 26236, 33878, 41520, 49162, 56804 anti-HIV-1_HeavyChain 3311 10953, 18595, 26237, 33879, 41521, 49163, 56805 anti-HIV-1_HeavyChain 3312 10954, 18596, 26238, 33880, 41522, 49164, 56806 anti-HIV-1_HeavyChain 3313 10955, 18597, 26239, 33881, 41523, 49165, 56807 anti-HIV-1_HeavyChain 3314 10956, 18598, 26240, 33882, 41524, 49166, 56808 anti-HIV-1_HeavyChain 3315 10957, 18599, 26241, 33883, 41525, 49167, 56809 anti-HIV-1_HeavyChain 3316 10958, 18600, 26242, 33884, 41526, 49168, 56810 anti-HIV-1_HeavyChain 3317 10959, 18601, 26243, 33885, 41527, 49169, 56811 anti-HIV-1_HeavyChain 3318 10960, 18602, 26244, 33886, 41528, 49170, 56812 anti-HIV-1_HeavyChain 3319 10961, 18603, 26245, 33887, 41529, 49171, 56813 anti-HIV-1_HeavyChain 3320 10962, 18604, 26246, 33888, 41530, 49172, 56814 anti-HIV-1_HeavyChain 3321 10963, 18605, 26247, 33889, 41531, 49173, 56815 anti-HIV-1_HeavyChain 3322 10964, 18606, 26248, 33890, 41532, 49174, 56816 anti-HIV-1_HeavyChain 3323 10965, 18607, 26249, 33891, 41533, 49175, 56817 anti-HIV-1_HeavyChain 3324 10966, 18608, 26250, 33892, 41534, 49176, 56818 anti-HIV-1_HeavyChain 3325 10967, 18609, 26251, 33893, 41535, 49177, 56819 anti-HIV-1_HeavyChain 3326 10968, 18610, 26252, 33894, 41536, 49178, 56820 anti-HIV-1_HeavyChain 3327 10969, 18611, 26253, 33895, 41537, 49179, 56821 anti-HIV-1_HeavyChain 3328 10970, 18612, 26254, 33896, 41538, 49180, 56822 anti-HIV-1_HeavyChain 3329 10971, 18613, 26255, 33897, 41539, 49181, 56823 anti-HIV-1_HeavyChain 3330 10972, 18614, 26256, 33898, 41540, 49182, 56824 anti-HIV-1_HeavyChain 3331 10973, 18615, 26257, 33899, 41541, 49183, 56825 anti-HIV-1_HeavyChain 3332 10974, 18616, 26258, 33900, 41542, 49184, 56826 anti-HIV-1_HeavyChain 3333 10975, 18617, 26259, 33901, 41543, 49185, 56827 anti-HIV-1_HeavyChain 3334 10976, 18618, 26260, 33902, 41544, 49186, 56828 anti-HIV-1_HeavyChain 3335 10977, 18619, 26261, 33903, 41545, 49187, 56829 anti-HIV-1_HeavyChain 3336 10978, 18620, 26262, 33904, 41546, 49188, 56830 anti-HIV-1_HeavyChain 3337 10979, 18621, 26263, 33905, 41547, 49189, 56831 anti-HIV-1_HeavyChain 3338 10980, 18622, 26264, 33906, 41548, 49190, 56832 anti-HIV-1_HeavyChain 3339 10981, 18623, 26265, 33907, 41549, 49191, 56833 anti-HIV-1_HeavyChain 3340 10982, 18624, 26266, 33908, 41550, 49192, 56834 anti-HIV-1_HeavyChain 3341 10983, 18625, 26267, 33909, 41551, 49193, 56835 anti-HIV-1_HeavyChain 3342 10984, 18626, 26268, 33910, 41552, 49194, 56836 anti-HIV-1_HeavyChain 3343 10985, 18627, 26269, 33911, 41553, 49195, 56837 anti-HIV-1_HeavyChain 3344 10986, 18628, 26270, 33912, 41554, 49196, 56838 anti-HIV-1_HeavyChain 3345 10987, 18629, 26271, 33913, 41555, 49197, 56839 anti-HIV-1_HeavyChain 3346 10988, 18630, 26272, 33914, 41556, 49198, 56840 anti-HIV-1_HeavyChain 3347 10989, 18631, 26273, 33915, 41557, 49199, 56841 anti-HIV-1_HeavyChain 3348 10990, 18632, 26274, 33916, 41558, 49200, 56842 anti-HIV-1_HeavyChain 3349 10991, 18633, 26275, 33917, 41559, 49201, 56843 anti-HIV-1_HeavyChain 3350 10992, 18634, 26276, 33918, 41560, 49202, 56844 anti-HIV-1_HeavyChain 3351 10993, 18635, 26277, 33919, 41561, 49203, 56845 anti-HIV-1_HeavyChain 3352 10994, 18636, 26278, 33920, 41562, 49204, 56846 anti-HIV-1_HeavyChain 3353 10995, 18637, 26279, 33921, 41563, 49205, 56847 anti-HIV-1_HeavyChain 3354 10996, 18638, 26280, 33922, 41564, 49206, 56848 anti-HIV-1_HeavyChain 3355 10997, 18639, 26281, 33923, 41565, 49207, 56849 anti-HIV-1_HeavyChain 3356 10998, 18640, 26282, 33924, 41566, 49208, 56850 anti-HIV-1_HeavyChain 3357 10999, 18641, 26283, 33925, 41567, 49209, 56851 anti-HIV-1_HeavyChain 3358 11000, 18642, 26284, 33926, 41568, 49210, 56852 anti-HIV-1_HeavyChain 3359 11001, 18643, 26285, 33927, 41569, 49211, 56853 anti-HIV-1_HeavyChain 3360 11002, 18644, 26286, 33928, 41570, 49212, 56854 anti-HIV-1_HeavyChain 3361 11003, 18645, 26287, 33929, 41571, 49213, 56855 anti-HIV-1_HeavyChain 3362 11004, 18646, 26288, 33930, 41572, 49214, 56856 anti-HIV-1_HeavyChain 3363 11005, 18647, 26289, 33931, 41573, 49215, 56857 anti-HIV-1_HeavyChain 3364 11006, 18648, 26290, 33932, 41574, 49216, 56858 anti-HIV-1_HeavyChain 3365 11007, 18649, 26291, 33933, 41575, 49217, 56859 anti-HIV-1_HeavyChain 3366 11008, 18650, 26292, 33934, 41576, 49218, 56860 anti-HIV-1_HeavyChain 3367 11009, 18651, 26293, 33935, 41577, 49219, 56861 anti-HIV-1_HeavyChain 3368 11010, 18652, 26294, 33936, 41578, 49220, 56862 anti-HIV-1_HeavyChain 3369 11011, 18653, 26295, 33937, 41579, 49221, 56863 anti-HIV-1_HeavyChain 3370 11012, 18654, 26296, 33938, 41580, 49222, 56864 anti-HIV-1_HeavyChain 3371 11013, 18655, 26297, 33939, 41581, 49223, 56865 anti-HIV-1_HeavyChain 3372 11014, 18656, 26298, 33940, 41582, 49224, 56866 anti-HIV-1_HeavyChain 3373 11015, 18657, 26299, 33941, 41583, 49225, 56867 anti-HIV-1_HeavyChain 3374 11016, 18658, 26300, 33942, 41584, 49226, 56868 anti-HIV-1_HeavyChain 3375 11017, 18659, 26301, 33943, 41585, 49227, 56869 anti-HIV-1_HeavyChain 3376 11018, 18660, 26302, 33944, 41586, 49228, 56870 anti-HIV-1_HeavyChain 3377 11019, 18661, 26303, 33945, 41587, 49229, 56871 anti-HIV-1_HeavyChain 3378 11020, 18662, 26304, 33946, 41588, 49230, 56872 anti-HIV-1_HeavyChain 3379 11021, 18663, 26305, 33947, 41589, 49231, 56873 anti-HIV-1_HeavyChain 3380 11022, 18664, 26306, 33948, 41590, 49232, 56874 anti-HIV-1_HeavyChain 3381 11023, 18665, 26307, 33949, 41591, 49233, 56875 anti-HIV-1_HeavyChain 3382 11024, 18666, 26308, 33950, 41592, 49234, 56876 anti-HIV-1_HeavyChain 3383 11025, 18667, 26309, 33951, 41593, 49235, 56877 anti-HIV-1_HeavyChain 3384 11026, 18668, 26310, 33952, 41594, 49236, 56878 anti-HIV-1_HeavyChain 3385 11027, 18669, 26311, 33953, 41595, 49237, 56879 anti-HIV-1_HeavyChain 3386 11028, 18670, 26312, 33954, 41596, 49238, 56880 anti-HIV-1_HeavyChain 3387 11029, 18671, 26313, 33955, 41597, 49239, 56881 anti-HIV-1_HeavyChain 3388 11030, 18672, 26314, 33956, 41598, 49240, 56882 anti-HIV-1_HeavyChain 3389 11031, 18673, 26315, 33957, 41599, 49241, 56883 anti-HIV-1_HeavyChain 3390 11032, 18674, 26316, 33958, 41600, 49242, 56884 anti-HIV-1_HeavyChain 3391 11033, 18675, 26317, 33959, 41601, 49243, 56885 anti-HIV-1_HeavyChain 3392 11034, 18676, 26318, 33960, 41602, 49244, 56886 anti-HIV-1_HeavyChain 3393 11035, 18677, 26319, 33961, 41603, 49245, 56887 anti-HIV-1_HeavyChain 3394 11036, 18678, 26320, 33962, 41604, 49246, 56888 anti-HIV-1_HeavyChain 3395 11037, 18679, 26321, 33963, 41605, 49247, 56889 anti-HIV-1_HeavyChain 3396 11038, 18680, 26322, 33964, 41606, 49248, 56890 anti-HIV-1_HeavyChain 3397 11039, 18681, 26323, 33965, 41607, 49249, 56891 anti-HIV-1_HeavyChain 3398 11040, 18682, 26324, 33966, 41608, 49250, 56892 anti-HIV-1_HeavyChain 3399 11041, 18683, 26325, 33967, 41609, 49251, 56893 anti-HIV-1_HeavyChain 3400 11042, 18684, 26326, 33968, 41610, 49252, 56894 anti-HIV-1_HeavyChain 3401 11043, 18685, 26327, 33969, 41611, 49253, 56895 anti-HIV-1_HeavyChain 3402 11044, 18686, 26328, 33970, 41612, 49254, 56896 anti-HIV-1_HeavyChain 3403 11045, 18687, 26329, 33971, 41613, 49255, 56897 anti-HIV-1_HeavyChain 3404 11046, 18688, 26330, 33972, 41614, 49256, 56898 anti-HIV-1_HeavyChain 3405 11047, 18689, 26331, 33973, 41615, 49257, 56899 anti-HIV-1_HeavyChain 3406 11048, 18690, 26332, 33974, 41616, 49258, 56900 anti-HIV-1_HeavyChain 3407 11049, 18691, 26333, 33975, 41617, 49259, 56901 anti-HIV-1_HeavyChain 3408 11050, 18692, 26334, 33976, 41618, 49260, 56902 anti-HIV-1_HeavyChain 3409 11051, 18693, 26335, 33977, 41619, 49261, 56903 anti-HIV-1_HeavyChain 3410 11052, 18694, 26336, 33978, 41620, 49262, 56904 anti-HIV-1_HeavyChain 3411 11053, 18695, 26337, 33979, 41621, 49263, 56905 anti-HIV-1_HeavyChain 3412 11054, 18696, 26338, 33980, 41622, 49264, 56906 anti-HIV-1_HeavyChain 3413 11055, 18697, 26339, 33981, 41623, 49265, 56907 anti-HIV-1_HeavyChain 3414 11056, 18698, 26340, 33982, 41624, 49266, 56908 anti-HIV-1_HeavyChain 3415 11057, 18699, 26341, 33983, 41625, 49267, 56909 anti-HIV-1_HeavyChain 3416 11058, 18700, 26342, 33984, 41626, 49268, 56910 anti-HIV-1_HeavyChain 3417 11059, 18701, 26343, 33985, 41627, 49269, 56911 anti-HIV-1_HeavyChain 3418 11060, 18702, 26344, 33986, 41628, 49270, 56912 anti-HIV-1_HeavyChain 3419 11061, 18703, 26345, 33987, 41629, 49271, 56913 anti-HIV-1_HeavyChain 3420 11062, 18704, 26346, 33988, 41630, 49272, 56914 anti-HIV-1_HeavyChain 3421 11063, 18705, 26347, 33989, 41631, 49273, 56915 anti-HIV-1_HeavyChain 3422 11064, 18706, 26348, 33990, 41632, 49274, 56916 anti-HIV-1_HeavyChain 3423 11065, 18707, 26349, 33991, 41633, 49275, 56917 anti-HIV-1_HeavyChain 3424 11066, 18708, 26350, 33992, 41634, 49276, 56918 anti-HIV-1_HeavyChain 3425 11067, 18709, 26351, 33993, 41635, 49277, 56919 anti-HIV-1_HeavyChain 3426 11068, 18710, 26352, 33994, 41636, 49278, 56920 anti-HIV-1_HeavyChain 3427 11069, 18711, 26353, 33995, 41637, 49279, 56921 anti-HIV-1_HeavyChain 3428 11070, 18712, 26354, 33996, 41638, 49280, 56922 anti-HIV-1_HeavyChain 3429 11071, 18713, 26355, 33997, 41639, 49281, 56923 anti-HIV-1_HeavyChain 3430 11072, 18714, 26356, 33998, 41640, 49282, 56924 anti-HIV-1_HeavyChain 3431 11073, 18715, 26357, 33999, 41641, 49283, 56925 anti-HIV-1_HeavyChain 3432 11074, 18716, 26358, 34000, 41642, 49284, 56926 anti-HIV-1_HeavyChain 3433 11075, 18717, 26359, 34001, 41643, 49285, 56927 anti-HIV-1_HeavyChain 3434 11076, 18718, 26360, 34002, 41644, 49286, 56928 anti-HIV-1_HeavyChain 3435 11077, 18719, 26361, 34003, 41645, 49287, 56929 anti-HIV-1_HeavyChain 3436 11078, 18720, 26362, 34004, 41646, 49288, 56930 anti-HIV-1_HeavyChain 3437 11079, 18721, 26363, 34005, 41647, 49289, 56931 anti-HIV-1_HeavyChain 3438 11080, 18722, 26364, 34006, 41648, 49290, 56932 anti-HIV-1_HeavyChain 3439 11081, 18723, 26365, 34007, 41649, 49291, 56933 anti-HIV-1_HeavyChain 3440 11082, 18724, 26366, 34008, 41650, 49292, 56934 anti-HIV-1_HeavyChain 3441 11083, 18725, 26367, 34009, 41651, 49293, 56935 anti-HIV-1_HeavyChain 3442 11084, 18726, 26368, 34010, 41652, 49294, 56936 anti-HIV-1_HeavyChain 3443 11085, 18727, 26369, 34011, 41653, 49295, 56937 anti-HIV-1_HeavyChain 3444 11086, 18728, 26370, 34012, 41654, 49296, 56938 anti-HIV-1_HeavyChain 3445 11087, 18729, 26371, 34013, 41655, 49297, 56939 anti-HIV-1_HeavyChain 3446 11088, 18730, 26372, 34014, 41656, 49298, 56940 anti-HIV-1_HeavyChain 3447 11089, 18731, 26373, 34015, 41657, 49299, 56941 anti-HIV-1_HeavyChain 3448 11090, 18732, 26374, 34016, 41658, 49300, 56942 anti-HIV-1_HeavyChain 3449 11091, 18733, 26375, 34017, 41659, 49301, 56943 anti-HIV-1_HeavyChain 3450 11092, 18734, 26376, 34018, 41660, 49302, 56944 anti-HIV-1_HeavyChain 3451 11093, 18735, 26377, 34019, 41661, 49303, 56945 anti-HIV-1_HeavyChain 3452 11094, 18736, 26378, 34020, 41662, 49304, 56946 anti-HIV-1_HeavyChain 3453 11095, 18737, 26379, 34021, 41663, 49305, 56947 anti-HIV-1_HeavyChain 3454 11096, 18738, 26380, 34022, 41664, 49306, 56948 anti-HIV-1_HeavyChain 3455 11097, 18739, 26381, 34023, 41665, 49307, 56949 anti-HIV-1_HeavyChain 3456 11098, 18740, 26382, 34024, 41666, 49308, 56950 anti-HIV-1_HeavyChain 3457 11099, 18741, 26383, 34025, 41667, 49309, 56951 anti-HIV-1_HeavyChain 3458 11100, 18742, 26384, 34026, 41668, 49310, 56952 anti-HIV-1_HeavyChain 3459 11101, 18743, 26385, 34027, 41669, 49311, 56953 anti-HIV-1_HeavyChain 3460 11102, 18744, 26386, 34028, 41670, 49312, 56954 anti-HIV-1_HeavyChain 3461 11103, 18745, 26387, 34029, 41671, 49313, 56955 anti-HIV-1_HeavyChain 3462 11104, 18746, 26388, 34030, 41672, 49314, 56956 anti-HIV-1_HeavyChain 3463 11105, 18747, 26389, 34031, 41673, 49315, 56957 anti-HIV-1_HeavyChain 3464 11106, 18748, 26390, 34032, 41674, 49316, 56958 anti-HIV-1_HeavyChain 3465 11107, 18749, 26391, 34033, 41675, 49317, 56959 anti-HIV-1_HeavyChain 3466 11108, 18750, 26392, 34034, 41676, 49318, 56960 anti-HIV-1_HeavyChain 3467 11109, 18751, 26393, 34035, 41677, 49319, 56961 anti-HIV-1_HeavyChain 3468 11110, 18752, 26394, 34036, 41678, 49320, 56962 anti-HIV-1_HeavyChain 3469 11111, 18753, 26395, 34037, 41679, 49321, 56963 anti-HIV-1_HeavyChain 3470 11112, 18754, 26396, 34038, 41680, 49322, 56964 anti-HIV-1_HeavyChain 3471 11113, 18755, 26397, 34039, 41681, 49323, 56965 anti-HIV-1_HeavyChain 3472 11114, 18756, 26398, 34040, 41682, 49324, 56966 anti-HIV-1_HeavyChain 3473 11115, 18757, 26399, 34041, 41683, 49325, 56967 anti-HIV-1_HeavyChain 3474 11116, 18758, 26400, 34042, 41684, 49326, 56968 anti-HIV-1_HeavyChain 3475 11117, 18759, 26401, 34043, 41685, 49327, 56969 anti-HIV-1_HeavyChain 3476 11118, 18760, 26402, 34044, 41686, 49328, 56970 anti-HIV-1_HeavyChain 3477 11119, 18761, 26403, 34045, 41687, 49329, 56971 anti-HIV-1_HeavyChain 3478 11120, 18762, 26404, 34046, 41688, 49330, 56972 anti-HIV-1_HeavyChain 3479 11121, 18763, 26405, 34047, 41689, 49331, 56973 anti-HIV-1_HeavyChain 3480 11122, 18764, 26406, 34048, 41690, 49332, 56974 anti-HIV-1_HeavyChain 3481 11123, 18765, 26407, 34049, 41691, 49333, 56975 anti-HIV-1_HeavyChain 3482 11124, 18766, 26408, 34050, 41692, 49334, 56976 anti-HIV-1_HeavyChain 3483 11125, 18767, 26409, 34051, 41693, 49335, 56977 anti-HIV-1_HeavyChain 3484 11126, 18768, 26410, 34052, 41694, 49336, 56978 anti-HIV-1_HeavyChain 3485 11127, 18769, 26411, 34053, 41695, 49337, 56979 anti-HIV-1_HeavyChain 3486 11128, 18770, 26412, 34054, 41696, 49338, 56980 anti-HIV-1_HeavyChain 3487 11129, 18771, 26413, 34055, 41697, 49339, 56981 anti-HIV-1_HeavyChain 3488 11130, 18772, 26414, 34056, 41698, 49340, 56982 anti-HIV-1_HeavyChain 3489 11131, 18773, 26415, 34057, 41699, 49341, 56983 anti-HIV-1_HeavyChain 3490 11132, 18774, 26416, 34058, 41700, 49342, 56984 anti-HIV-1_HeavyChain 3491 11133, 18775, 26417, 34059, 41701, 49343, 56985 anti-HIV-1_HeavyChain 3492 11134, 18776, 26418, 34060, 41702, 49344, 56986 anti-HIV-1_HeavyChain 3493 11135, 18777, 26419, 34061, 41703, 49345, 56987 anti-HIV-1_HeavyChain 3494 11136, 18778, 26420, 34062, 41704, 49346, 56988 anti-HIV-1_HeavyChain 3495 11137, 18779, 26421, 34063, 41705, 49347, 56989 anti-HIV-1_HeavyChain 3496 11138, 18780, 26422, 34064, 41706, 49348, 56990 anti-HIV-1_HeavyChain 3497 11139, 18781, 26423, 34065, 41707, 49349, 56991 anti-HIV-1_HeavyChain 3498 11140, 18782, 26424, 34066, 41708, 49350, 56992 anti-HIV-1_HeavyChain 3499 11141, 18783, 26425, 34067, 41709, 49351, 56993 anti-HIV-1_HeavyChain 3500 11142, 18784, 26426, 34068, 41710, 49352, 56994 anti-HIV-1_HeavyChain 3501 11143, 18785, 26427, 34069, 41711, 49353, 56995 anti-HIV-1_HeavyChain 3502 11144, 18786, 26428, 34070, 41712, 49354, 56996 anti-HIV-1_HeavyChain 3503 11145, 18787, 26429, 34071, 41713, 49355, 56997 anti-HIV-1_HeavyChain 3504 11146, 18788, 26430, 34072, 41714, 49356, 56998 anti-HIV-1_HeavyChain 3505 11147, 18789, 26431, 34073, 41715, 49357, 56999 anti-HIV-1_HeavyChain 3506 11148, 18790, 26432, 34074, 41716, 49358, 57000 anti-HIV-1_HeavyChain 3507 11149, 18791, 26433, 34075, 41717, 49359, 57001 anti-HIV-1_HeavyChain 3508 11150, 18792, 26434, 34076, 41718, 49360, 57002 anti-HIV-1_HeavyChain 3509 11151, 18793, 26435, 34077, 41719, 49361, 57003 anti-HIV-1_HeavyChain 3510 11152, 18794, 26436, 34078, 41720, 49362, 57004 anti-HIV-1_HeavyChain 3511 11153, 18795, 26437, 34079, 41721, 49363, 57005 anti-HIV-1_HeavyChain 3512 11154, 18796, 26438, 34080, 41722, 49364, 57006 anti-HIV-1_HeavyChain 3513 11155, 18797, 26439, 34081, 41723, 49365, 57007 anti-HIV-1_HeavyChain 3514 11156, 18798, 26440, 34082, 41724, 49366, 57008 anti-HIV-1_HeavyChain 3515 11157, 18799, 26441, 34083, 41725, 49367, 57009 anti-HIV-1_HeavyChain 3516 11158, 18800, 26442, 34084, 41726, 49368, 57010 anti-HIV-1_HeavyChain 3517 11159, 18801, 26443, 34085, 41727, 49369, 57011 anti-HIV-1_HeavyChain 3518 11160, 18802, 26444, 34086, 41728, 49370, 57012 anti-HIV-1_HeavyChain 3519 11161, 18803, 26445, 34087, 41729, 49371, 57013 anti-HIV-1_HeavyChain 3520 11162, 18804, 26446, 34088, 41730, 49372, 57014 anti-HIV-1_HeavyChain 3521 11163, 18805, 26447, 34089, 41731, 49373, 57015 anti-HIV-1_HeavyChain 3522 11164, 18806, 26448, 34090, 41732, 49374, 57016 anti-HIV-1_HeavyChain 3523 11165, 18807, 26449, 34091, 41733, 49375, 57017 anti-HIV-1_HeavyChain 3524 11166, 18808, 26450, 34092, 41734, 49376, 57018 anti-HIV-1_HeavyChain 3525 11167, 18809, 26451, 34093, 41735, 49377, 57019 anti-HIV-1_HeavyChain 3526 11168, 18810, 26452, 34094, 41736, 49378, 57020 anti-HIV-1_HeavyChain 3527 11169, 18811, 26453, 34095, 41737, 49379, 57021 anti-HIV-1_HeavyChain 3528 11170, 18812, 26454, 34096, 41738, 49380, 57022 anti-HIV-1_HeavyChain 3529 11171, 18813, 26455, 34097, 41739, 49381, 57023 anti-HIV-1_HeavyChain 3530 11172, 18814, 26456, 34098, 41740, 49382, 57024 anti-HIV-1_HeavyChain 3531 11173, 18815, 26457, 34099, 41741, 49383, 57025 anti-HIV-1_HeavyChain 3532 11174, 18816, 26458, 34100, 41742, 49384, 57026 anti-HIV-1_HeavyChain 3533 11175, 18817, 26459, 34101, 41743, 49385, 57027 anti-HIV-1_HeavyChain 3534 11176, 18818, 26460, 34102, 41744, 49386, 57028 anti-HIV-1_HeavyChain 3535 11177, 18819, 26461, 34103, 41745, 49387, 57029 anti-HIV-1_HeavyChain 3536 11178, 18820, 26462, 34104, 41746, 49388, 57030 anti-HIV-1_HeavyChain 3537 11179, 18821, 26463, 34105, 41747, 49389, 57031 anti-HIV-1_HeavyChain 3538 11180, 18822, 26464, 34106, 41748, 49390, 57032 anti-HIV-1_HeavyChain 3539 11181, 18823, 26465, 34107, 41749, 49391, 57033 anti-HIV-1_HeavyChain 3540 11182, 18824, 26466, 34108, 41750, 49392, 57034 anti-HIV-1_HeavyChain 3541 11183, 18825, 26467, 34109, 41751, 49393, 57035 anti-HIV-1_HeavyChain 3542 11184, 18826, 26468, 34110, 41752, 49394, 57036 anti-HIV-1_HeavyChain 3543 11185, 18827, 26469, 34111, 41753, 49395, 57037 anti-HIV-1_HeavyChain 3544 11186, 18828, 26470, 34112, 41754, 49396, 57038 anti-HIV-1_HeavyChain 3545 11187, 18829, 26471, 34113, 41755, 49397, 57039 anti-HIV-1_HeavyChain 3546 11188, 18830, 26472, 34114, 41756, 49398, 57040 anti-HIV-1_HeavyChain 3547 11189, 18831, 26473, 34115, 41757, 49399, 57041 anti-HIV-1_HeavyChain 3548 11190, 18832, 26474, 34116, 41758, 49400, 57042 anti-HIV-1_HeavyChain 3549 11191, 18833, 26475, 34117, 41759, 49401, 57043 anti-HIV-1_HeavyChain 3550 11192, 18834, 26476, 34118, 41760, 49402, 57044 anti-HIV-1_HeavyChain 3551 11193, 18835, 26477, 34119, 41761, 49403, 57045 anti-HIV-1_HeavyChain 3552 11194, 18836, 26478, 34120, 41762, 49404, 57046 anti-HIV-1_HeavyChain 3553 11195, 18837, 26479, 34121, 41763, 49405, 57047 anti-HIV-1_HeavyChain 3554 11196, 18838, 26480, 34122, 41764, 49406, 57048 anti-HIV-1_HeavyChain 3555 11197, 18839, 26481, 34123, 41765, 49407, 57049 anti-HIV-1_HeavyChain 3556 11198, 18840, 26482, 34124, 41766, 49408, 57050 anti-HIV-1_HeavyChain 3557 11199, 18841, 26483, 34125, 41767, 49409, 57051 anti-HIV-1_HeavyChain 3558 11200, 18842, 26484, 34126, 41768, 49410, 57052 anti-HIV-1_HeavyChain 3559 11201, 18843, 26485, 34127, 41769, 49411, 57053 anti-HIV-1_HeavyChain 3560 11202, 18844, 26486, 34128, 41770, 49412, 57054 anti-HIV-1_HeavyChain 3561 11203, 18845, 26487, 34129, 41771, 49413, 57055 anti-HIV-1_HeavyChain 3562 11204, 18846, 26488, 34130, 41772, 49414, 57056 anti-HIV-1_HeavyChain 3563 11205, 18847, 26489, 34131, 41773, 49415, 57057 anti-HIV-1_HeavyChain 3564 11206, 18848, 26490, 34132, 41774, 49416, 57058 anti-HIV-1_HeavyChain 3565 11207, 18849, 26491, 34133, 41775, 49417, 57059 anti-HIV-1_HeavyChain 3566 11208, 18850, 26492, 34134, 41776, 49418, 57060 anti-HIV-1_HeavyChain 3567 11209, 18851, 26493, 34135, 41777, 49419, 57061 anti-HIV-1_HeavyChain 3568 11210, 18852, 26494, 34136, 41778, 49420, 57062 anti-HIV-1_HeavyChain 3569 11211, 18853, 26495, 34137, 41779, 49421, 57063 anti-HIV-1_HeavyChain 3570 11212, 18854, 26496, 34138, 41780, 49422, 57064 anti-HIV-1_HeavyChain 3571 11213, 18855, 26497, 34139, 41781, 49423, 57065 anti-HIV-1_HeavyChain 3572 11214, 18856, 26498, 34140, 41782, 49424, 57066 anti-HIV-1_HeavyChain 3573 11215, 18857, 26499, 34141, 41783, 49425, 57067 anti-HIV-1_HeavyChain 3574 11216, 18858, 26500, 34142, 41784, 49426, 57068 anti-HIV-1_HeavyChain 3575 11217, 18859, 26501, 34143, 41785, 49427, 57069 anti-HIV-1_HeavyChain 3576 11218, 18860, 26502, 34144, 41786, 49428, 57070 anti-HIV-1_HeavyChain 3577 11219, 18861, 26503, 34145, 41787, 49429, 57071 anti-HIV-1_HeavyChain 3578 11220, 18862, 26504, 34146, 41788, 49430, 57072 anti-HIV-1_HeavyChain 3579 11221, 18863, 26505, 34147, 41789, 49431, 57073 anti-HIV-1_HeavyChain 3580 11222, 18864, 26506, 34148, 41790, 49432, 57074 anti-HIV-1_HeavyChain 3581 11223, 18865, 26507, 34149, 41791, 49433, 57075 anti-HIV-1_HeavyChain 3582 11224, 18866, 26508, 34150, 41792, 49434, 57076 anti-HIV-1_HeavyChain 3583 11225, 18867, 26509, 34151, 41793, 49435, 57077 anti-HIV-1_HeavyChain 3584 11226, 18868, 26510, 34152, 41794, 49436, 57078 anti-HIV-1_HeavyChain 3585 11227, 18869, 26511, 34153, 41795, 49437, 57079 anti-HIV-1_HeavyChain 3586 11228, 18870, 26512, 34154, 41796, 49438, 57080 anti-HIV-1_HeavyChain 3587 11229, 18871, 26513, 34155, 41797, 49439, 57081 anti-HIV-1_HeavyChain 3588 11230, 18872, 26514, 34156, 41798, 49440, 57082 anti-HIV-1_HeavyChain 3589 11231, 18873, 26515, 34157, 41799, 49441, 57083 anti-HIV-1_HeavyChain 3590 11232, 18874, 26516, 34158, 41800, 49442, 57084 anti-HIV-1_HeavyChain 3591 11233, 18875, 26517, 34159, 41801, 49443, 57085 anti-HIV-1_HeavyChain 3592 11234, 18876, 26518, 34160, 41802, 49444, 57086 anti-HIV-1_HeavyChain 3593 11235, 18877, 26519, 34161, 41803, 49445, 57087 anti-HIV-1_HeavyChain 3594 11236, 18878, 26520, 34162, 41804, 49446, 57088 anti-HIV-1_HeavyChain 3595 11237, 18879, 26521, 34163, 41805, 49447, 57089 anti-HIV-1_HeavyChain 3596 11238, 18880, 26522, 34164, 41806, 49448, 57090 anti-HIV-1_HeavyChain 3597 11239, 18881, 26523, 34165, 41807, 49449, 57091 anti-HIV-1_HeavyChain 3598 11240, 18882, 26524, 34166, 41808, 49450, 57092 anti-HIV-1_HeavyChain 3599 11241, 18883, 26525, 34167, 41809, 49451, 57093 anti-HIV-1_HeavyChain 3600 11242, 18884, 26526, 34168, 41810, 49452, 57094 anti-HIV-1_HeavyChain 3601 11243, 18885, 26527, 34169, 41811, 49453, 57095 anti-HIV-1_HeavyChain 3602 11244, 18886, 26528, 34170, 41812, 49454, 57096 anti-HIV-1_HeavyChain 3603 11245, 18887, 26529, 34171, 41813, 49455, 57097 anti-HIV-1_HeavyChain 3604 11246, 18888, 26530, 34172, 41814, 49456, 57098 anti-HIV-1_HeavyChain 3605 11247, 18889, 26531, 34173, 41815, 49457, 57099 anti-HIV-1_HeavyChain 3606 11248, 18890, 26532, 34174, 41816, 49458, 57100 anti-HIV-1_HeavyChain 3607 11249, 18891, 26533, 34175, 41817, 49459, 57101 anti-HIV-1_HeavyChain 3608 11250, 18892, 26534, 34176, 41818, 49460, 57102 anti-HIV-1_HeavyChain 3609 11251, 18893, 26535, 34177, 41819, 49461, 57103 anti-HIV-1_HeavyChain 3610 11252, 18894, 26536, 34178, 41820, 49462, 57104 anti-HIV-1_HeavyChain 3611 11253, 18895, 26537, 34179, 41821, 49463, 57105 anti-HIV-1_HeavyChain 3612 11254, 18896, 26538, 34180, 41822, 49464, 57106 anti-HIV-1_HeavyChain 3613 11255, 18897, 26539, 34181, 41823, 49465, 57107 anti-HIV-1_HeavyChain 3614 11256, 18898, 26540, 34182, 41824, 49466, 57108 anti-HIV-1_HeavyChain 3615 11257, 18899, 26541, 34183, 41825, 49467, 57109 anti-HIV-1_HeavyChain 3616 11258, 18900, 26542, 34184, 41826, 49468, 57110 anti-HIV-1_HeavyChain 3617 11259, 18901, 26543, 34185, 41827, 49469, 57111 anti-HIV-1_HeavyChain 3618 11260, 18902, 26544, 34186, 41828, 49470, 57112 anti-HIV-1_HeavyChain 3619 11261, 18903, 26545, 34187, 41829, 49471, 57113 anti-HIV-1_HeavyChain 3620 11262, 18904, 26546, 34188, 41830, 49472, 57114 anti-HIV-1_HeavyChain 3621 11263, 18905, 26547, 34189, 41831, 49473, 57115 anti-HIV-1_HeavyChain 3622 11264, 18906, 26548, 34190, 41832, 49474, 57116 anti-HIV-1_HeavyChain 3623 11265, 18907, 26549, 34191, 41833, 49475, 57117 anti-HIV-1_HeavyChain 3624 11266, 18908, 26550, 34192, 41834, 49476, 57118 anti-HIV-1_HeavyChain 3625 11267, 18909, 26551, 34193, 41835, 49477, 57119 anti-HIV-1_HeavyChain 3626 11268, 18910, 26552, 34194, 41836, 49478, 57120 anti-HIV-1_HeavyChain 3627 11269, 18911, 26553, 34195, 41837, 49479, 57121 anti-HIV-1_HeavyChain 3628 11270, 18912, 26554, 34196, 41838, 49480, 57122 anti-HIV-1_HeavyChain 3629 11271, 18913, 26555, 34197, 41839, 49481, 57123 anti-HIV-1_HeavyChain 3630 11272, 18914, 26556, 34198, 41840, 49482, 57124 anti-HIV-1_HeavyChain 3631 11273, 18915, 26557, 34199, 41841, 49483, 57125 anti-HIV-1_HeavyChain 3632 11274, 18916, 26558, 34200, 41842, 49484, 57126 anti-HIV-1_HeavyChain 3633 11275, 18917, 26559, 34201, 41843, 49485, 57127 anti-HIV-1_HeavyChain 3634 11276, 18918, 26560, 34202, 41844, 49486, 57128 anti-HIV-1_HeavyChain 3635 11277, 18919, 26561, 34203, 41845, 49487, 57129 anti-HIV-1_HeavyChain 3636 11278, 18920, 26562, 34204, 41846, 49488, 57130 anti-HIV-1_HeavyChain 3637 11279, 18921, 26563, 34205, 41847, 49489, 57131 anti-HIV-1_HeavyChain 3638 11280, 18922, 26564, 34206, 41848, 49490, 57132 anti-HIV-1_HeavyChain 3639 11281, 18923, 26565, 34207, 41849, 49491, 57133 anti-HIV-1_HeavyChain 3640 11282, 18924, 26566, 34208, 41850, 49492, 57134 anti-HIV-1_HeavyChain 3641 11283, 18925, 26567, 34209, 41851, 49493, 57135 anti-HIV-1_HeavyChain 3642 11284, 18926, 26568, 34210, 41852, 49494, 57136 anti-HIV-1_HeavyChain 3643 11285, 18927, 26569, 34211, 41853, 49495, 57137 anti-HIV-1_HeavyChain 3644 11286, 18928, 26570, 34212, 41854, 49496, 57138 anti-HIV-1_HeavyChain 3645 11287, 18929, 26571, 34213, 41855, 49497, 57139 anti-HIV-1_HeavyChain 3646 11288, 18930, 26572, 34214, 41856, 49498, 57140 anti-HIV-1_HeavyChain 3647 11289, 18931, 26573, 34215, 41857, 49499, 57141 anti-HIV-1_HeavyChain 3648 11290, 18932, 26574, 34216, 41858, 49500, 57142 anti-HIV-1_HeavyChain 3649 11291, 18933, 26575, 34217, 41859, 49501, 57143 anti-HIV-1_HeavyChain 3650 11292, 18934, 26576, 34218, 41860, 49502, 57144 anti-HIV-1_HeavyChain 3651 11293, 18935, 26577, 34219, 41861, 49503, 57145 anti-HIV-1_HeavyChain 3652 11294, 18936, 26578, 34220, 41862, 49504, 57146 anti-HIV-1_HeavyChain 3653 11295, 18937, 26579, 34221, 41863, 49505, 57147 anti-HIV-1_HeavyChain 3654 11296, 18938, 26580, 34222, 41864, 49506, 57148 anti-HIV-1_HeavyChain 3655 11297, 18939, 26581, 34223, 41865, 49507, 57149 anti-HIV-1_HeavyChain 3656 11298, 18940, 26582, 34224, 41866, 49508, 57150 anti-HIV-1_HeavyChain 3657 11299, 18941, 26583, 34225, 41867, 49509, 57151 anti-HIV-1_HeavyChain 3658 11300, 18942, 26584, 34226, 41868, 49510, 57152 anti-HIV-1_HeavyChain 3659 11301, 18943, 26585, 34227, 41869, 49511, 57153 anti-HIV-1_HeavyChain 3660 11302, 18944, 26586, 34228, 41870, 49512, 57154 anti-HIV-1_HeavyChain 3661 11303, 18945, 26587, 34229, 41871, 49513, 57155 anti-HIV-1_HeavyChain 3662 11304, 18946, 26588, 34230, 41872, 49514, 57156 anti-HIV-1_HeavyChain 3663 11305, 18947, 26589, 34231, 41873, 49515, 57157 anti-HIV-1_HeavyChain 3664 11306, 18948, 26590, 34232, 41874, 49516, 57158 anti-HIV-1_HeavyChain 3665 11307, 18949, 26591, 34233, 41875, 49517, 57159 anti-HIV-1_HeavyChain 3666 11308, 18950, 26592, 34234, 41876, 49518, 57160 anti-HIV-1_HeavyChain 3667 11309, 18951, 26593, 34235, 41877, 49519, 57161 anti-HIV-1_HeavyChain 3668 11310, 18952, 26594, 34236, 41878, 49520, 57162 anti-HIV-1_HeavyChain 3669 11311, 18953, 26595, 34237, 41879, 49521, 57163 anti-HIV-1_HeavyChain 3670 11312, 18954, 26596, 34238, 41880, 49522, 57164 anti-HIV-1_HeavyChain 3671 11313, 18955, 26597, 34239, 41881, 49523, 57165 anti-HIV-1_HeavyChain 3672 11314, 18956, 26598, 34240, 41882, 49524, 57166 anti-HIV-1_HeavyChain 3673 11315, 18957, 26599, 34241, 41883, 49525, 57167 anti-HIV-1_HeavyChain 3674 11316, 18958, 26600, 34242, 41884, 49526, 57168 anti-HIV-1_HeavyChain 3675 11317, 18959, 26601, 34243, 41885, 49527, 57169 anti-HIV-1_HeavyChain 3676 11318, 18960, 26602, 34244, 41886, 49528, 57170 anti-HIV-1_HeavyChain 3677 11319, 18961, 26603, 34245, 41887, 49529, 57171 anti-HIV-1_HeavyChain 3678 11320, 18962, 26604, 34246, 41888, 49530, 57172 anti-HIV-1_HeavyChain 3679 11321, 18963, 26605, 34247, 41889, 49531, 57173 anti-HIV-1_HeavyChain 3680 11322, 18964, 26606, 34248, 41890, 49532, 57174 anti-HIV-1_HeavyChain 3681 11323, 18965, 26607, 34249, 41891, 49533, 57175 anti-HIV-1_HeavyChain 3682 11324, 18966, 26608, 34250, 41892, 49534, 57176 anti-HIV-1_HeavyChain 3683 11325, 18967, 26609, 34251, 41893, 49535, 57177 anti-HIV-1_HeavyChain 3684 11326, 18968, 26610, 34252, 41894, 49536, 57178 anti-HIV-1_HeavyChain 3685 11327, 18969, 26611, 34253, 41895, 49537, 57179 anti-HIV-1_HeavyChain 3686 11328, 18970, 26612, 34254, 41896, 49538, 57180 anti-HIV-1_HeavyChain 3687 11329, 18971, 26613, 34255, 41897, 49539, 57181 anti-HIV-1_HeavyChain 3688 11330, 18972, 26614, 34256, 41898, 49540, 57182 anti-HIV-1_HeavyChain 3689 11331, 18973, 26615, 34257, 41899, 49541, 57183 anti-HIV-1_HeavyChain 3690 11332, 18974, 26616, 34258, 41900, 49542, 57184 anti-HIV-1_HeavyChain 3691 11333, 18975, 26617, 34259, 41901, 49543, 57185 anti-HIV-1_HeavyChain 3692 11334, 18976, 26618, 34260, 41902, 49544, 57186 anti-HIV-1_HeavyChain 3693 11335, 18977, 26619, 34261, 41903, 49545, 57187 anti-HIV-1_HeavyChain 3694 11336, 18978, 26620, 34262, 41904, 49546, 57188 anti-HIV-1_HeavyChain 3695 11337, 18979, 26621, 34263, 41905, 49547, 57189 anti-HIV-1_HeavyChain 3696 11338, 18980, 26622, 34264, 41906, 49548, 57190 anti-HIV-1_HeavyChain 3697 11339, 18981, 26623, 34265, 41907, 49549, 57191 anti-HIV-1_HeavyChain 3698 11340, 18982, 26624, 34266, 41908, 49550, 57192 anti-HIV-1_HeavyChain 3699 11341, 18983, 26625, 34267, 41909, 49551, 57193 anti-HIV-1_HeavyChain 3700 11342, 18984, 26626, 34268, 41910, 49552, 57194 anti-HIV-1_HeavyChain 3701 11343, 18985, 26627, 34269, 41911, 49553, 57195 anti-HIV-1_HeavyChain 3702 11344, 18986, 26628, 34270, 41912, 49554, 57196 anti-HIV-1_HeavyChain 3703 11345, 18987, 26629, 34271, 41913, 49555, 57197 anti-HIV-1_HeavyChain 3704 11346, 18988, 26630, 34272, 41914, 49556, 57198 anti-HIV-1_HeavyChain 3705 11347, 18989, 26631, 34273, 41915, 49557, 57199 anti-HIV-1_HeavyChain 3706 11348, 18990, 26632, 34274, 41916, 49558, 57200 anti-HIV-1_HeavyChain 3707 11349, 18991, 26633, 34275, 41917, 49559, 57201 anti-HIV-1_HeavyChain 3708 11350, 18992, 26634, 34276, 41918, 49560, 57202 anti-HIV-1_HeavyChain 3709 11351, 18993, 26635, 34277, 41919, 49561, 57203 anti-HIV-1_HeavyChain 3710 11352, 18994, 26636, 34278, 41920, 49562, 57204 anti-HIV-1_HeavyChain 3711 11353, 18995, 26637, 34279, 41921, 49563, 57205 anti-HIV-1_HeavyChain 3712 11354, 18996, 26638, 34280, 41922, 49564, 57206 anti-HIV-1_HeavyChain 3713 11355, 18997, 26639, 34281, 41923, 49565, 57207 anti-HIV-1_HeavyChain 3714 11356, 18998, 26640, 34282, 41924, 49566, 57208 anti-HIV-1_HeavyChain 3715 11357, 18999, 26641, 34283, 41925, 49567, 57209 anti-HIV-1_HeavyChain 3716 11358, 19000, 26642, 34284, 41926, 49568, 57210 anti-HIV-1_HeavyChain 3717 11359, 19001, 26643, 34285, 41927, 49569, 57211 anti-HIV-1_HeavyChain 3718 11360, 19002, 26644, 34286, 41928, 49570, 57212 anti-HIV-1_HeavyChain 3719 11361, 19003, 26645, 34287, 41929, 49571, 57213 anti-HIV-1_HeavyChain 3720 11362, 19004, 26646, 34288, 41930, 49572, 57214 anti-HIV-1_HeavyChain 3721 11363, 19005, 26647, 34289, 41931, 49573, 57215 anti-HIV-1_HeavyChain 3722 11364, 19006, 26648, 34290, 41932, 49574, 57216 anti-HIV-1_HeavyChain 3723 11365, 19007, 26649, 34291, 41933, 49575, 57217 anti-HIV-1_HeavyChain 3724 11366, 19008, 26650, 34292, 41934, 49576, 57218 anti-HIV-1_HeavyChain 3725 11367, 19009, 26651, 34293, 41935, 49577, 57219 anti-HIV-1_HeavyChain 3726 11368, 19010, 26652, 34294, 41936, 49578, 57220 anti-HIV-1_HeavyChain 3727 11369, 19011, 26653, 34295, 41937, 49579, 57221 anti-HIV-1_HeavyChain 3728 11370, 19012, 26654, 34296, 41938, 49580, 57222 anti-HIV-1_HeavyChain 3729 11371, 19013, 26655, 34297, 41939, 49581, 57223 anti-HIV-1_HeavyChain 3730 11372, 19014, 26656, 34298, 41940, 49582, 57224 anti-HIV-1_HeavyChain 3731 11373, 19015, 26657, 34299, 41941, 49583, 57225 anti-HIV-1_HeavyChain 3732 11374, 19016, 26658, 34300, 41942, 49584, 57226 anti-HIV-1_HeavyChain 3733 11375, 19017, 26659, 34301, 41943, 49585, 57227 anti-HIV-1_HeavyChain 3734 11376, 19018, 26660, 34302, 41944, 49586, 57228 anti-HIV-1_HeavyChain 3735 11377, 19019, 26661, 34303, 41945, 49587, 57229 anti-HIV-1_HeavyChain 3736 11378, 19020, 26662, 34304, 41946, 49588, 57230 anti-HIV-1_HeavyChain 3737 11379, 19021, 26663, 34305, 41947, 49589, 57231 anti-HIV-1_HeavyChain 3738 11380, 19022, 26664, 34306, 41948, 49590, 57232 anti-HIV-1_HeavyChain 3739 11381, 19023, 26665, 34307, 41949, 49591, 57233 anti-HIV-1_HeavyChain 3740 11382, 19024, 26666, 34308, 41950, 49592, 57234 anti-HIV-1_HeavyChain 3741 11383, 19025, 26667, 34309, 41951, 49593, 57235 anti-HIV-1_HeavyChain 3742 11384, 19026, 26668, 34310, 41952, 49594, 57236 anti-HIV-1_HeavyChain 3743 11385, 19027, 26669, 34311, 41953, 49595, 57237 anti-HIV-1_HeavyChain 3744 11386, 19028, 26670, 34312, 41954, 49596, 57238 anti-HIV-1_HeavyChain 3745 11387, 19029, 26671, 34313, 41955, 49597, 57239 anti-HIV-1_HeavyChain 3746 11388, 19030, 26672, 34314, 41956, 49598, 57240 anti-HIV-1_HeavyChain 3747 11389, 19031, 26673, 34315, 41957, 49599, 57241 anti-HIV-1_HeavyChain 3748 11390, 19032, 26674, 34316, 41958, 49600, 57242 anti-HIV-1_HeavyChain 3749 11391, 19033, 26675, 34317, 41959, 49601, 57243 anti-HIV-1_HeavyChain 3750 11392, 19034, 26676, 34318, 41960, 49602, 57244 anti-HIV-1_HeavyChain 3751 11393, 19035, 26677, 34319, 41961, 49603, 57245 anti-HIV-1_HeavyChain 3752 11394, 19036, 26678, 34320, 41962, 49604, 57246 anti-HIV-1_HeavyChain 3753 11395, 19037, 26679, 34321, 41963, 49605, 57247 anti-HIV-1_HeavyChain 3754 11396, 19038, 26680, 34322, 41964, 49606, 57248 anti-HIV-1_HeavyChain 3755 11397, 19039, 26681, 34323, 41965, 49607, 57249 anti-HIV-1_HeavyChain 3756 11398, 19040, 26682, 34324, 41966, 49608, 57250 anti-HIV-1_HeavyChain 3757 11399, 19041, 26683, 34325, 41967, 49609, 57251 anti-HIV-1_HeavyChain 3758 11400, 19042, 26684, 34326, 41968, 49610, 57252 anti-HIV-1_HeavyChain 3759 11401, 19043, 26685, 34327, 41969, 49611, 57253 anti-HIV-1_HeavyChain 3760 11402, 19044, 26686, 34328, 41970, 49612, 57254 anti-HIV-1_HeavyChain 3761 11403, 19045, 26687, 34329, 41971, 49613, 57255 anti-HIV-1_HeavyChain 3762 11404, 19046, 26688, 34330, 41972, 49614, 57256 anti-HIV-1_HeavyChain 3763 11405, 19047, 26689, 34331, 41973, 49615, 57257 anti-HIV-1_HeavyChain 3764 11406, 19048, 26690, 34332, 41974, 49616, 57258 anti-HIV-1_HeavyChain 3765 11407, 19049, 26691, 34333, 41975, 49617, 57259 anti-HIV-1_HeavyChain 3766 11408, 19050, 26692, 34334, 41976, 49618, 57260 anti-HIV-1_HeavyChain 3767 11409, 19051, 26693, 34335, 41977, 49619, 57261 anti-HIV-1_HeavyChain 3768 11410, 19052, 26694, 34336, 41978, 49620, 57262 anti-HIV-1_HeavyChain 3769 11411, 19053, 26695, 34337, 41979, 49621, 57263 anti-HIV-1_HeavyChain 3770 11412, 19054, 26696, 34338, 41980, 49622, 57264 anti-HIV-1_HeavyChain 3771 11413, 19055, 26697, 34339, 41981, 49623, 57265 anti-HIV-1_HeavyChain 3772 11414, 19056, 26698, 34340, 41982, 49624, 57266 anti-HIV-1_HeavyChain 3773 11415, 19057, 26699, 34341, 41983, 49625, 57267 anti-HIV-1_HeavyChain 3774 11416, 19058, 26700, 34342, 41984, 49626, 57268 anti-HIV-1_HeavyChain 3775 11417, 19059, 26701, 34343, 41985, 49627, 57269 anti-HIV-1_HeavyChain 3776 11418, 19060, 26702, 34344, 41986, 49628, 57270 anti-HIV-1_HeavyChain 3777 11419, 19061, 26703, 34345, 41987, 49629, 57271 anti-HIV-1_HeavyChain 3778 11420, 19062, 26704, 34346, 41988, 49630, 57272 anti-HIV-1_HeavyChain 3779 11421, 19063, 26705, 34347, 41989, 49631, 57273 anti-HIV-1_HeavyChain 3780 11422, 19064, 26706, 34348, 41990, 49632, 57274 anti-HIV-1_HeavyChain 3781 11423, 19065, 26707, 34349, 41991, 49633, 57275 anti-HIV-1_HeavyChain 3782 11424, 19066, 26708, 34350, 41992, 49634, 57276 anti-HIV-1_HeavyChain 3783 11425, 19067, 26709, 34351, 41993, 49635, 57277 anti-HIV-1_HeavyChain 3784 11426, 19068, 26710, 34352, 41994, 49636, 57278 anti-HIV-1_HeavyChain 3785 11427, 19069, 26711, 34353, 41995, 49637, 57279 anti-HIV-1_HeavyChain 3786 11428, 19070, 26712, 34354, 41996, 49638, 57280 anti-HIV-1_HeavyChain 3787 11429, 19071, 26713, 34355, 41997, 49639, 57281 anti-HIV-1_HeavyChain 3788 11430, 19072, 26714, 34356, 41998, 49640, 57282 anti-HIV-1_HeavyChain 3789 11431, 19073, 26715, 34357, 41999, 49641, 57283 anti-HIV-1_HeavyChain 3790 11432, 19074, 26716, 34358, 42000, 49642, 57284 anti-HIV-1_HeavyChain 3791 11433, 19075, 26717, 34359, 42001, 49643, 57285 anti-HIV-1_HeavyChain 3792 11434, 19076, 26718, 34360, 42002, 49644, 57286 anti-HIV-1_HeavyChain 3793 11435, 19077, 26719, 34361, 42003, 49645, 57287 anti-HIV-1_HeavyChain 3794 11436, 19078, 26720, 34362, 42004, 49646, 57288 anti-HIV-1_HeavyChain 3795 11437, 19079, 26721, 34363, 42005, 49647, 57289 anti-HIV-1_HeavyChain 3796 11438, 19080, 26722, 34364, 42006, 49648, 57290 anti-HIV-1_HeavyChain 3797 11439, 19081, 26723, 34365, 42007, 49649, 57291 anti-HIV-1_HeavyChain 3798 11440, 19082, 26724, 34366, 42008, 49650, 57292 anti-HIV-1_HeavyChain 3799 11441, 19083, 26725, 34367, 42009, 49651, 57293 anti-HIV-1_HeavyChain 3800 11442, 19084, 26726, 34368, 42010, 49652, 57294 anti-HIV-1_HeavyChain 3801 11443, 19085, 26727, 34369, 42011, 49653, 57295 anti-HIV-1_HeavyChain 3802 11444, 19086, 26728, 34370, 42012, 49654, 57296 anti-HIV-1_HeavyChain 3803 11445, 19087, 26729, 34371, 42013, 49655, 57297 anti-HIV-1_HeavyChain 3804 11446, 19088, 26730, 34372, 42014, 49656, 57298 anti-HIV-1_HeavyChain 3805 11447, 19089, 26731, 34373, 42015, 49657, 57299 anti-HIV-1_HeavyChain 3806 11448, 19090, 26732, 34374, 42016, 49658, 57300 anti-HIV-1_HeavyChain 3807 11449, 19091, 26733, 34375, 42017, 49659, 57301 anti-HIV-1_HeavyChain 3808 11450, 19092, 26734, 34376, 42018, 49660, 57302 anti-HIV-1_HeavyChain 3809 11451, 19093, 26735, 34377, 42019, 49661, 57303 anti-HIV-1_HeavyChain 3810 11452, 19094, 26736, 34378, 42020, 49662, 57304 anti-HIV-1_HeavyChain 3811 11453, 19095, 26737, 34379, 42021, 49663, 57305 anti-HIV-1_HeavyChain 3812 11454, 19096, 26738, 34380, 42022, 49664, 57306 anti-HIV-1_HeavyChain 3813 11455, 19097, 26739, 34381, 42023, 49665, 57307 anti-HIV-1_HeavyChain 3814 11456, 19098, 26740, 34382, 42024, 49666, 57308 anti-HIV-1_HeavyChain 3815 11457, 19099, 26741, 34383, 42025, 49667, 57309 anti-HIV-1_HeavyChain 3816 11458, 19100, 26742, 34384, 42026, 49668, 57310 anti-HIV-1_HeavyChain 3817 11459, 19101, 26743, 34385, 42027, 49669, 57311 anti-HIV-1_HeavyChain 3818 11460, 19102, 26744, 34386, 42028, 49670, 57312 anti-HIV-1_HeavyChain 3819 11461, 19103, 26745, 34387, 42029, 49671, 57313 anti-HIV-1_HeavyChain 3820 11462, 19104, 26746, 34388, 42030, 49672, 57314 anti-HIV-1_HeavyChain 3821 11463, 19105, 26747, 34389, 42031, 49673, 57315 anti-HIV-1_HeavyChain 3822 11464, 19106, 26748, 34390, 42032, 49674, 57316 anti-HIV-1_HeavyChain 3823 11465, 19107, 26749, 34391, 42033, 49675, 57317 anti-HIV-1_HeavyChain 3824 11466, 19108, 26750, 34392, 42034, 49676, 57318 anti-HIV-1_HeavyChain 3825 11467, 19109, 26751, 34393, 42035, 49677, 57319 anti-HIV-1_HeavyChain 3826 11468, 19110, 26752, 34394, 42036, 49678, 57320 anti-HIV-1_HeavyChain 3827 11469, 19111, 26753, 34395, 42037, 49679, 57321 anti-HIV-1_HeavyChain 3828 11470, 19112, 26754, 34396, 42038, 49680, 57322 anti-HIV-1_HeavyChain 3829 11471, 19113, 26755, 34397, 42039, 49681, 57323 anti-HIV-1_HeavyChain 3830 11472, 19114, 26756, 34398, 42040, 49682, 57324 anti-HIV-1_HeavyChain 3831 11473, 19115, 26757, 34399, 42041, 49683, 57325 anti-HIV-1_HeavyChain 3832 11474, 19116, 26758, 34400, 42042, 49684, 57326 anti-HIV-1_HeavyChain 3833 11475, 19117, 26759, 34401, 42043, 49685, 57327 anti-HIV-1_HeavyChain 3834 11476, 19118, 26760, 34402, 42044, 49686, 57328 anti-HIV-1_HeavyChain 3835 11477, 19119, 26761, 34403, 42045, 49687, 57329 anti-HIV-1_HeavyChain 3836 11478, 19120, 26762, 34404, 42046, 49688, 57330 anti-HIV-1_HeavyChain 3837 11479, 19121, 26763, 34405, 42047, 49689, 57331 anti-HIV-1_HeavyChain 3838 11480, 19122, 26764, 34406, 42048, 49690, 57332 anti-HIV-1_HeavyChain 3839 11481, 19123, 26765, 34407, 42049, 49691, 57333 anti-HIV-1_HeavyChain 3840 11482, 19124, 26766, 34408, 42050, 49692, 57334 anti-HIV-1_HeavyChain 3841 11483, 19125, 26767, 34409, 42051, 49693, 57335 anti-HIV-1_HeavyChain 3842 11484, 19126, 26768, 34410, 42052, 49694, 57336 anti-HIV-1_HeavyChain 3843 11485, 19127, 26769, 34411, 42053, 49695, 57337 anti-HIV-1_HeavyChain 3844 11486, 19128, 26770, 34412, 42054, 49696, 57338 anti-HIV-1_HeavyChain 3845 11487, 19129, 26771, 34413, 42055, 49697, 57339 anti-HIV-1_HeavyChain 3846 11488, 19130, 26772, 34414, 42056, 49698, 57340 anti-HIV-1_HeavyChain 3847 11489, 19131, 26773, 34415, 42057, 49699, 57341 anti-HIV-1_HeavyChain 3848 11490, 19132, 26774, 34416, 42058, 49700, 57342 anti-HIV-1_HeavyChain 3849 11491, 19133, 26775, 34417, 42059, 49701, 57343 anti-HIV-1_HeavyChain 3850 11492, 19134, 26776, 34418, 42060, 49702, 57344 anti-HIV-1_HeavyChain 3851 11493, 19135, 26777, 34419, 42061, 49703, 57345 anti-HIV-1_HeavyChain 3852 11494, 19136, 26778, 34420, 42062, 49704, 57346 anti-HIV-1_HeavyChain 3853 11495, 19137, 26779, 34421, 42063, 49705, 57347 anti-HIV-1_HeavyChain 3854 11496, 19138, 26780, 34422, 42064, 49706, 57348 anti-HIV-1_HeavyChain 3855 11497, 19139, 26781, 34423, 42065, 49707, 57349 anti-HIV-1_HeavyChain 3856 11498, 19140, 26782, 34424, 42066, 49708, 57350 anti-HIV-1_HeavyChain 3857 11499, 19141, 26783, 34425, 42067, 49709, 57351 anti-HIV-1_HeavyChain 3858 11500, 19142, 26784, 34426, 42068, 49710, 57352 anti-HIV-1_HeavyChain 3859 11501, 19143, 26785, 34427, 42069, 49711, 57353 anti-HIV-1_HeavyChain 3860 11502, 19144, 26786, 34428, 42070, 49712, 57354 anti-HIV-1_HeavyChain 3861 11503, 19145, 26787, 34429, 42071, 49713, 57355 anti-HIV-1_HeavyChain 3862 11504, 19146, 26788, 34430, 42072, 49714, 57356 anti-HIV-1_HeavyChain 3863 11505, 19147, 26789, 34431, 42073, 49715, 57357 anti-HIV-1_HeavyChain 3864 11506, 19148, 26790, 34432, 42074, 49716, 57358 anti-HIV-1_HeavyChain 3865 11507, 19149, 26791, 34433, 42075, 49717, 57359 anti-HIV-1_HeavyChain 3866 11508, 19150, 26792, 34434, 42076, 49718, 57360 anti-HIV-1_HeavyChain 3867 11509, 19151, 26793, 34435, 42077, 49719, 57361 anti-HIV-1_HeavyChain 3868 11510, 19152, 26794, 34436, 42078, 49720, 57362 anti-HIV-1_HeavyChain 3869 11511, 19153, 26795, 34437, 42079, 49721, 57363 anti-HIV-1_HeavyChain 3870 11512, 19154, 26796, 34438, 42080, 49722, 57364 anti-HIV-1_HeavyChain 3871 11513, 19155, 26797, 34439, 42081, 49723, 57365 anti-HIV-1_HeavyChain 3872 11514, 19156, 26798, 34440, 42082, 49724, 57366 anti-HIV-1_HeavyChain 3873 11515, 19157, 26799, 34441, 42083, 49725, 57367 anti-HIV-1_HeavyChain 3874 11516, 19158, 26800, 34442, 42084, 49726, 57368 anti-HIV-1_HeavyChain 3875 11517, 19159, 26801, 34443, 42085, 49727, 57369 anti-HIV-1_HeavyChain 3876 11518, 19160, 26802, 34444, 42086, 49728, 57370 anti-HIV-1_HeavyChain 3877 11519, 19161, 26803, 34445, 42087, 49729, 57371 anti-HIV-1_HeavyChain 3878 11520, 19162, 26804, 34446, 42088, 49730, 57372 anti-HIV-1_HeavyChain 3879 11521, 19163, 26805, 34447, 42089, 49731, 57373 anti-HIV-1_HeavyChain 3880 11522, 19164, 26806, 34448, 42090, 49732, 57374 anti-HIV-1_HeavyChain 3881 11523, 19165, 26807, 34449, 42091, 49733, 57375 anti-HIV-1_HeavyChain 3882 11524, 19166, 26808, 34450, 42092, 49734, 57376 anti-HIV-1_HeavyChain 3883 11525, 19167, 26809, 34451, 42093, 49735, 57377 anti-HIV-1_HeavyChain 3884 11526, 19168, 26810, 34452, 42094, 49736, 57378 anti-HIV-1_HeavyChain 3885 11527, 19169, 26811, 34453, 42095, 49737, 57379 anti-HIV-1_HeavyChain 3886 11528, 19170, 26812, 34454, 42096, 49738, 57380 anti-HIV-1_HeavyChain 3887 11529, 19171, 26813, 34455, 42097, 49739, 57381 anti-HIV-1_HeavyChain 3888 11530, 19172, 26814, 34456, 42098, 49740, 57382 anti-HIV-1_HeavyChain 3889 11531, 19173, 26815, 34457, 42099, 49741, 57383 anti-HIV-1_HeavyChain 3890 11532, 19174, 26816, 34458, 42100, 49742, 57384 anti-HIV-1_HeavyChain 3891 11533, 19175, 26817, 34459, 42101, 49743, 57385 anti-HIV-1_HeavyChain 3892 11534, 19176, 26818, 34460, 42102, 49744, 57386 anti-HIV-1_HeavyChain 3893 11535, 19177, 26819, 34461, 42103, 49745, 57387 anti-HIV-1_HeavyChain 3894 11536, 19178, 26820, 34462, 42104, 49746, 57388 anti-HIV-1_HeavyChain 3895 11537, 19179, 26821, 34463, 42105, 49747, 57389 anti-HIV-1_HeavyChain 3896 11538, 19180, 26822, 34464, 42106, 49748, 57390 anti-HIV-1_HeavyChain 3897 11539, 19181, 26823, 34465, 42107, 49749, 57391 anti-HIV-1_HeavyChain 3898 11540, 19182, 26824, 34466, 42108, 49750, 57392 anti-HIV-1_HeavyChain 3899 11541, 19183, 26825, 34467, 42109, 49751, 57393 anti-HIV-1_HeavyChain 3900 11542, 19184, 26826, 34468, 42110, 49752, 57394 anti-HIV-1_HeavyChain 3901 11543, 19185, 26827, 34469, 42111, 49753, 57395 anti-HIV-1_HeavyChain 3902 11544, 19186, 26828, 34470, 42112, 49754, 57396 anti-HIV-1_HeavyChain 3903 11545, 19187, 26829, 34471, 42113, 49755, 57397 anti-HIV-1_HeavyChain 3904 11546, 19188, 26830, 34472, 42114, 49756, 57398 anti-HIV-1_HeavyChain 3905 11547, 19189, 26831, 34473, 42115, 49757, 57399 anti-HIV-1_HeavyChain 3906 11548, 19190, 26832, 34474, 42116, 49758, 57400 anti-HIV-1_HeavyChain 3907 11549, 19191, 26833, 34475, 42117, 49759, 57401 anti-HIV-1_HeavyChain 3908 11550, 19192, 26834, 34476, 42118, 49760, 57402 anti-HIV-1_HeavyChain 3909 11551, 19193, 26835, 34477, 42119, 49761, 57403 anti-HIV-1_HeavyChain 3910 11552, 19194, 26836, 34478, 42120, 49762, 57404 anti-HIV-1_HeavyChain 3911 11553, 19195, 26837, 34479, 42121, 49763, 57405 anti-HIV-1_HeavyChain 3912 11554, 19196, 26838, 34480, 42122, 49764, 57406 anti-HIV-1_HeavyChain 3913 11555, 19197, 26839, 34481, 42123, 49765, 57407 anti-HIV-1_HeavyChain 3914 11556, 19198, 26840, 34482, 42124, 49766, 57408 anti-HIV-1_HeavyChain 3915 11557, 19199, 26841, 34483, 42125, 49767, 57409 anti-HIV-1_HeavyChain 3916 11558, 19200, 26842, 34484, 42126, 49768, 57410 anti-HIV-1_HeavyChain 3917 11559, 19201, 26843, 34485, 42127, 49769, 57411 anti-HIV-1_HeavyChain 3918 11560, 19202, 26844, 34486, 42128, 49770, 57412 anti-HIV-1_HeavyChain 3919 11561, 19203, 26845, 34487, 42129, 49771, 57413 anti-HIV-1_HeavyChain 3920 11562, 19204, 26846, 34488, 42130, 49772, 57414 anti-HIV-1_HeavyChain 3921 11563, 19205, 26847, 34489, 42131, 49773, 57415 anti-HIV-1_HeavyChain 3922 11564, 19206, 26848, 34490, 42132, 49774, 57416 anti-HIV-1_HeavyChain 3923 11565, 19207, 26849, 34491, 42133, 49775, 57417 anti-HIV-1_HeavyChain 3924 11566, 19208, 26850, 34492, 42134, 49776, 57418 anti-HIV-1_HeavyChain 3925 11567, 19209, 26851, 34493, 42135, 49777, 57419 anti-HIV-1_HeavyChain 3926 11568, 19210, 26852, 34494, 42136, 49778, 57420 anti-HIV-1_HeavyChain 3927 11569, 19211, 26853, 34495, 42137, 49779, 57421 anti-HIV-1_HeavyChain 3928 11570, 19212, 26854, 34496, 42138, 49780, 57422 anti-HIV-1_HeavyChain 3929 11571, 19213, 26855, 34497, 42139, 49781, 57423 anti-HIV-1_HeavyChain 3930 11572, 19214, 26856, 34498, 42140, 49782, 57424 anti-HIV-1_HeavyChain 3931 11573, 19215, 26857, 34499, 42141, 49783, 57425 anti-HIV-1_HeavyChain 3932 11574, 19216, 26858, 34500, 42142, 49784, 57426 anti-HIV-1_HeavyChain 3933 11575, 19217, 26859, 34501, 42143, 49785, 57427 anti-HIV-1_HeavyChain 3934 11576, 19218, 26860, 34502, 42144, 49786, 57428 anti-HIV-1_HeavyChain 3935 11577, 19219, 26861, 34503, 42145, 49787, 57429 anti-HIV-1_HeavyChain 3936 11578, 19220, 26862, 34504, 42146, 49788, 57430 anti-HIV-1_HeavyChain 3937 11579, 19221, 26863, 34505, 42147, 49789, 57431 anti-HIV-1_HeavyChain 3938 11580, 19222, 26864, 34506, 42148, 49790, 57432 anti-HIV-1_HeavyChain 3939 11581, 19223, 26865, 34507, 42149, 49791, 57433 anti-HIV-1_HeavyChain 3940 11582, 19224, 26866, 34508, 42150, 49792, 57434 anti-HIV-1_HeavyChain 3941 11583, 19225, 26867, 34509, 42151, 49793, 57435 anti-HIV-1_HeavyChain 3942 11584, 19226, 26868, 34510, 42152, 49794, 57436 anti-HIV-1_HeavyChain 3943 11585, 19227, 26869, 34511, 42153, 49795, 57437 anti-HIV-1_HeavyChain 3944 11586, 19228, 26870, 34512, 42154, 49796, 57438 anti-HIV-1_HeavyChain 3945 11587, 19229, 26871, 34513, 42155, 49797, 57439 anti-HIV-1_HeavyChain 3946 11588, 19230, 26872, 34514, 42156, 49798, 57440 anti-HIV-1_HeavyChain 3947 11589, 19231, 26873, 34515, 42157, 49799, 57441 anti-HIV-1_HeavyChain 3948 11590, 19232, 26874, 34516, 42158, 49800, 57442 anti-HIV-1_HeavyChain 3949 11591, 19233, 26875, 34517, 42159, 49801, 57443 anti-HIV-1_HeavyChain 3950 11592, 19234, 26876, 34518, 42160, 49802, 57444 anti-HIV-1_HeavyChain 3951 11593, 19235, 26877, 34519, 42161, 49803, 57445 anti-HIV-1_HeavyChain 3952 11594, 19236, 26878, 34520, 42162, 49804, 57446 anti-HIV-1_HeavyChain 3953 11595, 19237, 26879, 34521, 42163, 49805, 57447 anti-HIV-1_HeavyChain 3954 11596, 19238, 26880, 34522, 42164, 49806, 57448 anti-HIV-1_HeavyChain 3955 11597, 19239, 26881, 34523, 42165, 49807, 57449 anti-HIV-1_HeavyChain 3956 11598, 19240, 26882, 34524, 42166, 49808, 57450 anti-HIV-1_HeavyChain 3957 11599, 19241, 26883, 34525, 42167, 49809, 57451 anti-HIV-1_HeavyChain 3958 11600, 19242, 26884, 34526, 42168, 49810, 57452 anti-HIV-1_HeavyChain 3959 11601, 19243, 26885, 34527, 42169, 49811, 57453 anti-HIV-1_HeavyChain 3960 11602, 19244, 26886, 34528, 42170, 49812, 57454 anti-HIV-1_HeavyChain 3961 11603, 19245, 26887, 34529, 42171, 49813, 57455 anti-HIV-1_HeavyChain 3962 11604, 19246, 26888, 34530, 42172, 49814, 57456 anti-HIV-1_HeavyChain 3963 11605, 19247, 26889, 34531, 42173, 49815, 57457 anti-HIV-1_HeavyChain 3964 11606, 19248, 26890, 34532, 42174, 49816, 57458 anti-HIV-1_HeavyChain 3965 11607, 19249, 26891, 34533, 42175, 49817, 57459 anti-HIV-1_HeavyChain 3966 11608, 19250, 26892, 34534, 42176, 49818, 57460 anti-HIV-1_HeavyChain 3967 11609, 19251, 26893, 34535, 42177, 49819, 57461 anti-HIV-1_HeavyChain 3968 11610, 19252, 26894, 34536, 42178, 49820, 57462 anti-HIV-1_HeavyChain 3969 11611, 19253, 26895, 34537, 42179, 49821, 57463 anti-HIV-1_HeavyChain 3970 11612, 19254, 26896, 34538, 42180, 49822, 57464 anti-HIV-1_HeavyChain 3971 11613, 19255, 26897, 34539, 42181, 49823, 57465 anti-HIV-1_HeavyChain 3972 11614, 19256, 26898, 34540, 42182, 49824, 57466 anti-HIV-1_HeavyChain 3973 11615, 19257, 26899, 34541, 42183, 49825, 57467 anti-HIV-1_HeavyChain 3974 11616, 19258, 26900, 34542, 42184, 49826, 57468 anti-HIV-1_HeavyChain 3975 11617, 19259, 26901, 34543, 42185, 49827, 57469 anti-HIV-1_HeavyChain 3976 11618, 19260, 26902, 34544, 42186, 49828, 57470 anti-HIV-1_HeavyChain 3977 11619, 19261, 26903, 34545, 42187, 49829, 57471 anti-HIV-1_HeavyChain 3978 11620, 19262, 26904, 34546, 42188, 49830, 57472 anti-HIV-1_HeavyChain 3979 11621, 19263, 26905, 34547, 42189, 49831, 57473 anti-HIV-1_HeavyChain 3980 11622, 19264, 26906, 34548, 42190, 49832, 57474 anti-HIV-1_HeavyChain 3981 11623, 19265, 26907, 34549, 42191, 49833, 57475 anti-HIV-1_HeavyChain 3982 11624, 19266, 26908, 34550, 42192, 49834, 57476 anti-HIV-1_HeavyChain 3983 11625, 19267, 26909, 34551, 42193, 49835, 57477 anti-HIV-1_HeavyChain 3984 11626, 19268, 26910, 34552, 42194, 49836, 57478 anti-HIV-1_HeavyChain 3985 11627, 19269, 26911, 34553, 42195, 49837, 57479 anti-HIV-1_HeavyChain 3986 11628, 19270, 26912, 34554, 42196, 49838, 57480 anti-HIV-1_HeavyChain 3987 11629, 19271, 26913, 34555, 42197, 49839, 57481 anti-HIV-1_HeavyChain 3988 11630, 19272, 26914, 34556, 42198, 49840, 57482 anti-HIV-1_HeavyChain 3989 11631, 19273, 26915, 34557, 42199, 49841, 57483 anti-HIV-1_HeavyChain 3990 11632, 19274, 26916, 34558, 42200, 49842, 57484 anti-HIV-1_HeavyChain 3991 11633, 19275, 26917, 34559, 42201, 49843, 57485 anti-HIV-1_HeavyChain 3992 11634, 19276, 26918, 34560, 42202, 49844, 57486 anti-HIV-1_HeavyChain 3993 11635, 19277, 26919, 34561, 42203, 49845, 57487 anti-HIV-1_HeavyChain 3994 11636, 19278, 26920, 34562, 42204, 49846, 57488 anti-HIV-1_HeavyChain 3995 11637, 19279, 26921, 34563, 42205, 49847, 57489 anti-HIV-1_HeavyChain 3996 11638, 19280, 26922, 34564, 42206, 49848, 57490 anti-HIV-1_HeavyChain 3997 11639, 19281, 26923, 34565, 42207, 49849, 57491 anti-HIV-1_HeavyChain 3998 11640, 19282, 26924, 34566, 42208, 49850, 57492 anti-HIV-1_HeavyChain 3999 11641, 19283, 26925, 34567, 42209, 49851, 57493 anti-HIV-1_HeavyChain 4000 11642, 19284, 26926, 34568, 42210, 49852, 57494 anti-HIV_5CIN_LightChain 4001 11643, 19285, 26927, 34569, 42211, 49853, 57495 anti-HIV_5CIN_HeavyChain 4002 11644, 19286, 26928, 34570, 42212, 49854, 57496 anti-HIV_5CIL_HeavyChain 4003 11645, 19287, 26929, 34571, 42213, 49855, 57497 anti-HIV_5CIP_A-Chain 4004 11646, 19288, 26930, 34572, 42214, 49856, 57498 anti-HIV_5CIP_HeavyChain 4005 11647, 19289, 26931, 34573, 42215, 49857, 57499 anti-HIV_4JKP_LightChain 4006 11648, 19290, 26932, 34574, 42216, 49858, 57500 anti-HIV_3TNN_E-Chain 4007 11649, 19291, 26933, 34575, 42217, 49859, 57501 anti-HIV_3BQU_B-Chain 4008 11650, 19292, 26934, 34576, 42218, 49860, 57502 anti-HIV_3BQU_A-Chain 4009 11651, 19293, 26935, 34577, 42219, 49861, 57503 anti-HIV_IgG_VR-Chain 4010 11652, 19294, 26936, 34578, 42220, 49862, 57504 anti-HIV_IgG_HeavyChain 4011 11653, 19295, 26937, 34579, 42221, 49863, 57505 anti-HIV_4P9M_HeavyChain 4012 11654, 19296, 26938, 34580, 42222, 49864, 57506 anti-HIV_4P9M_LightChain 4013 11655, 19297, 26939, 34581, 42223, 49865, 57507 anti-HIV_4P9H_C-Chain 4014 11656, 19298, 26940, 34582, 42224, 49866, 57508 anti-HIV_4YBL_A-Chain 4015 11657, 19299, 26941, 34583, 42225, 49867, 57509 anti-HIV_4R4N_V-Chain 4016 11658, 19300, 26942, 34584, 42226, 49868, 57510 anti-HIV_4JKP_G-Chain 4017 11659, 19301, 26943, 34585, 42227, 49869, 57511 anti-HIV_3BQU_D-Chain 4018 11660, 19302, 26944, 34586, 42228, 49870, 57512 anti-HIV_3BQU_C-Chain 4019 11661, 19303, 26945, 34587, 42229, 49871, 57513 anti-HIV_Ig_LightChain 4020 11662, 19304, 26946, 34588, 42230, 49872, 57514 anti-HIV_Ig_HeavyChain 4021 11663, 19305, 26947, 34589, 42231, 49873, 57515 anti-HIV_4P9H_G-Chain 4022 11664, 19306, 26948, 34590, 42232, 49874, 57516 anti-HIV_Chain 4023 11665, 19307, 26949, 34591, 42233, 49875, 57517 anti-HIV_Chain 4024 11666, 19308, 26950, 34592, 42234, 49876, 57518 anti-HIV_Chain 4025 11667, 19309, 26951, 34593, 42235, 49877, 57519 anti-HIV_Chain 4026 11668, 19310, 26952, 34594, 42236, 49878, 57520 anti-HIV_Chain 4027 11669, 19311, 26953, 34595, 42237, 49879, 57521 anti-HIV_Chain 4028 11670, 19312, 26954, 34596, 42238, 49880, 57522 anti-HIV_Chain 4029 11671, 19313, 26955, 34597, 42239, 49881, 57523 anti-HIV_Chain 4030 11672, 19314, 26956, 34598, 42240, 49882, 57524 anti-HIV_Chain 4031 11673, 19315, 26957, 34599, 42241, 49883, 57525 anti-HIV_Chain 4032 11674, 19316, 26958, 34600, 42242, 49884, 57526 anti-HIV_Chain 4033 11675, 19317, 26959, 34601, 42243, 49885, 57527 anti-HIV_Chain 4034 11676, 19318, 26960, 34602, 42244, 49886, 57528 anti-HIV_Chain 4035 11677, 19319, 26961, 34603, 42245, 49887, 57529 anti-HIV_Chain 4036 11678, 19320, 26962, 34604, 42246, 49888, 57530 anti-HIV_Chain 4037 11679, 19321, 26963, 34605, 42247, 49889, 57531 anti-HIV_Chain 4038 11680, 19322, 26964, 34606, 42248, 49890, 57532 anti-HIV_Chain 4039 11681, 19323, 26965, 34607, 42249, 49891, 57533 anti-HIV_Chain 4040 11682, 19324, 26966, 34608, 42250, 49892, 57534 anti-HIV_Chain 4041 11683, 19325, 26967, 34609, 42251, 49893, 57535 anti-HIV_Chain 4042 11684, 19326, 26968, 34610, 42252, 49894, 57536 anti-HIV_Chain 4043 11685, 19327, 26969, 34611, 42253, 49895, 57537 anti-HIV_Chain 4044 11686, 19328, 26970, 34612, 42254, 49896, 57538 anti-HIV_Chain 4045 11687, 19329, 26971, 34613, 42255, 49897, 57539 anti-HIV_Chain 4046 11688, 19330, 26972, 34614, 42256, 49898, 57540 anti-HIV_Chain 4047 11689, 19331, 26973, 34615, 42257, 49899, 57541 anti-HIV_Chain 4048 11690, 19332, 26974, 34616, 42258, 49900, 57542 anti-HIV_Chain 4049 11691, 19333, 26975, 34617, 42259, 49901, 57543 anti-HIV_Chain 4050 11692, 19334, 26976, 34618, 42260, 49902, 57544 anti-HIV_Chain 4051 11693, 19335, 26977, 34619, 42261, 49903, 57545 anti-HIV_Chain 4052 11694, 19336, 26978, 34620, 42262, 49904, 57546 anti-HIV_Chain 4053 11695, 19337, 26979, 34621, 42263, 49905, 57547 anti-HIV_Chain 4054 11696, 19338, 26980, 34622, 42264, 49906, 57548 anti-HIV_Chain 4055 11697, 19339, 26981, 34623, 42265, 49907, 57549 anti-HIV_Chain 4056 11698, 19340, 26982, 34624, 42266, 49908, 57550 anti-HIV_Chain 4057 11699, 19341, 26983, 34625, 42267, 49909, 57551 anti-HIV_Chain 4058 11700, 19342, 26984, 34626, 42268, 49910, 57552 anti-HIV_Chain 4059 11701, 19343, 26985, 34627, 42269, 49911, 57553 anti-HIV_Chain 4060 11702, 19344, 26986, 34628, 42270, 49912, 57554 anti-HIV_Chain 4061 11703, 19345, 26987, 34629, 42271, 49913, 57555 anti-HIV_Chain 4062 11704, 19346, 26988, 34630, 42272, 49914, 57556 anti-HIV_Chain 4063 11705, 19347, 26989, 34631, 42273, 49915, 57557 anti-HIV_Chain 4064 11706, 19348, 26990, 34632, 42274, 49916, 57558 anti-HIV_Chain 4065 11707, 19349, 26991, 34633, 42275, 49917, 57559 anti-HIV_Chain 4066 11708, 19350, 26992, 34634, 42276, 49918, 57560 anti-HIV_Chain 4067 11709, 19351, 26993, 34635, 42277, 49919, 57561 anti-HIV_Chain 4068 11710, 19352, 26994, 34636, 42278, 49920, 57562 anti-HIV_Chain 4069 11711, 19353, 26995, 34637, 42279, 49921, 57563 anti-HIV_Chain 4070 11712, 19354, 26996, 34638, 42280, 49922, 57564 anti-HIV_LightChain 4071 11713, 19355, 26997, 34639, 42281, 49923, 57565 anti-HIV_LightChain 4072 11714, 19356, 26998, 34640, 42282, 49924, 57566 anti-HIV_Chain 4073 11715, 19357, 26999, 34641, 42283, 49925, 57567 anti-HIV_Chain 4074 11716, 19358, 27000, 34642, 42284, 49926, 57568 anti-HIV_Chain 4075 11717, 19359, 27001, 34643, 42285, 49927, 57569 anti-HIV_HeavyChain 4076 11718, 19360, 27002, 34644, 42286, 49928, 57570 anti-HIV_Chain 4077 11719, 19361, 27003, 34645, 42287, 49929, 57571 anti-HIV_Chain 4078 11720, 19362, 27004, 34646, 42288, 49930, 57572 anti-HIV_LightChain 4079 11721, 19363, 27005, 34647, 42289, 49931, 57573 anti-HIV_LightChain 4080 11722, 19364, 27006, 34648, 42290, 49932, 57574 anti-HIV_Chain 4081 11723, 19365, 27007, 34649, 42291, 49933, 57575 anti-HIV_Chain 4082 11724, 19366, 27008, 34650, 42292, 49934, 57576 anti-HIV_Chain 4083 11725, 19367, 27009, 34651, 42293, 49935, 57577 anti-HIV_Chain 4084 11726, 19368, 27010, 34652, 42294, 49936, 57578 anti-HIV_Chain 4085 11727, 19369, 27011, 34653, 42295, 49937, 57579 anti-HIV_Chain 4086 11728, 19370, 27012, 34654, 42296, 49938, 57580 anti-HIV_Chain 4087 11729, 19371, 27013, 34655, 42297, 49939, 57581 anti-HIV_Chain 4088 11730, 19372, 27014, 34656, 42298, 49940, 57582 anti-HIV_Chain 4089 11731, 19373, 27015, 34657, 42299, 49941, 57583 anti-HIV_Chain 4090 11732, 19374, 27016, 34658, 42300, 49942, 57584 anti-HIV_Chain 4091 11733, 19375, 27017, 34659, 42301, 49943, 57585 anti-HIV_Chain 4092 11734, 19376, 27018, 34660, 42302, 49944, 57586 anti-HIV_Chain 4093 11735, 19377, 27019, 34661, 42303, 49945, 57587 anti-HIV_Chain 4094 11736, 19378, 27020, 34662, 42304, 49946, 57588 anti-HIV_Chain 4095 11737, 19379, 27021, 34663, 42305, 49947, 57589 anti-HIV_Chain 4096 11738, 19380, 27022, 34664, 42306, 49948, 57590 anti-HIV_Chain 4097 11739, 19381, 27023, 34665, 42307, 49949, 57591 anti-HIV_Chain 4098 11740, 19382, 27024, 34666, 42308, 49950, 57592 anti-HIV_Chain 4099 11741, 19383, 27025, 34667, 42309, 49951, 57593 anti-HIV_Chain 4100 11742, 19384, 27026, 34668, 42310, 49952, 57594 anti-HIV_Chain 4101 11743, 19385, 27027, 34669, 42311, 49953, 57595 anti-HIV_Chain 4102 11744, 19386, 27028, 34670, 42312, 49954, 57596 anti-HIV_Chain 4103 11745, 19387, 27029, 34671, 42313, 49955, 57597 anti-HIV_Chain 4104 11746, 19388, 27030, 34672, 42314, 49956, 57598 anti-HIV_Chain 4105 11747, 19389, 27031, 34673, 42315, 49957, 57599 anti-HIV_Chain 4106 11748, 19390, 27032, 34674, 42316, 49958, 57600 anti-HIV_Chain 4107 11749, 19391, 27033, 34675, 42317, 49959, 57601 anti-HIV_Chain 4108 11750, 19392, 27034, 34676, 42318, 49960, 57602 anti-HIV_Chain 4109 11751, 19393, 27035, 34677, 42319, 49961, 57603 anti-HIV_Chain 4110 11752, 19394, 27036, 34678, 42320, 49962, 57604 anti-HIV_Chain 4111 11753, 19395, 27037, 34679, 42321, 49963, 57605 anti-HIV_Chain 4112 11754, 19396, 27038, 34680, 42322, 49964, 57606 anti-HIV_LightChain 4113 11755, 19397, 27039, 34681, 42323, 49965, 57607 anti-HIV_LightChain 4114 11756, 19398, 27040, 34682, 42324, 49966, 57608 anti-HIV_LightChain 4115 11757, 19399, 27041, 34683, 42325, 49967, 57609 anti-HIV_LightChain 4116 11758, 19400, 27042, 34684, 42326, 49968, 57610 anti-HIV_LightChain 4117 11759, 19401, 27043, 34685, 42327, 49969, 57611 anti-HIV_LightChain 4118 11760, 19402, 27044, 34686, 42328, 49970, 57612 anti-HIV_LightChain 4119 11761, 19403, 27045, 34687, 42329, 49971, 57613 anti-HIV_LightChain 4120 11762, 19404, 27046, 34688, 42330, 49972, 57614 anti-HIV_LightChain 4121 11763, 19405, 27047, 34689, 42331, 49973, 57615 anti-HIV_LightChain 4122 11764, 19406, 27048, 34690, 42332, 49974, 57616 anti-HIV_LightChain 4123 11765, 19407, 27049, 34691, 42333, 49975, 57617 anti-HIV_LightChain 4124 11766, 19408, 27050, 34692, 42334, 49976, 57618 anti-HIV_LightChain 4125 11767, 19409, 27051, 34693, 42335, 49977, 57619 anti-HIV_LightChain 4126 11768, 19410, 27052, 34694, 42336, 49978, 57620 anti-HIV_LightChain 4127 11769, 19411, 27053, 34695, 42337, 49979, 57621 anti-HIV_Chain 4128 11770, 19412, 27054, 34696, 42338, 49980, 57622 anti-HIV_Chain 4129 11771, 19413, 27055, 34697, 42339, 49981, 57623 anti-HIV_Chain 4130 11772, 19414, 27056, 34698, 42340, 49982, 57624 anti-HIV_Chain 4131 11773, 19415, 27057, 34699, 42341, 49983, 57625 anti-HIV_Chain 4132 11774, 19416, 27058, 34700, 42342, 49984, 57626 anti-HIV_Chain 4133 11775, 19417, 27059, 34701, 42343, 49985, 57627 anti-HIV_Chain 4134 11776, 19418, 27060, 34702, 42344, 49986, 57628 anti-HIV_Chain 4135 11777, 19419, 27061, 34703, 42345, 49987, 57629 anti-HIV_Chain 4136 11778, 19420, 27062, 34704, 42346, 49988, 57630 anti-HIV_HeavyChain 4137 11779, 19421, 27063, 34705, 42347, 49989, 57631 anti-HIV_Chain 4138 11780, 19422, 27064, 34706, 42348, 49990, 57632 anti-HIV_Chain 4139 11781, 19423, 27065, 34707, 42349, 49991, 57633 anti-HIV_Chain 4140 11782, 19424, 27066, 34708, 42350, 49992, 57634 anti-HIV_Chain 4141 11783, 19425, 27067, 34709, 42351, 49993, 57635 anti-HIV_Chain 4142 11784, 19426, 27068, 34710, 42352, 49994, 57636 anti-HIV_Chain 4143 11785, 19427, 27069, 34711, 42353, 49995, 57637 anti-HIV_Chain 4144 11786, 19428, 27070, 34712, 42354, 49996, 57638 anti-HIV_Chain 4145 11787, 19429, 27071, 34713, 42355, 49997, 57639 anti-HIV_Chain 4146 11788, 19430, 27072, 34714, 42356, 49998, 57640 anti-HIV_Chain 4147 11789, 19431, 27073, 34715, 42357, 49999, 57641 anti-HIV_Chain 4148 11790, 19432, 27074, 34716, 42358, 50000, 57642 anti-HIV_Chain 4149 11791, 19433, 27075, 34717, 42359, 50001, 57643 anti-HIV_Chain 4150 11792, 19434, 27076, 34718, 42360, 50002, 57644 anti-HIV_Chain 4151 11793, 19435, 27077, 34719, 42361, 50003, 57645 anti-HIV_Chain 4152 11794, 19436, 27078, 34720, 42362, 50004, 57646 anti-HIV_Chain 4153 11795, 19437, 27079, 34721, 42363, 50005, 57647 anti-HIV_Chain 4154 11796, 19438, 27080, 34722, 42364, 50006, 57648 anti-HIV_Chain 4155 11797, 19439, 27081, 34723, 42365, 50007, 57649 anti-HIV_Chain 4156 11798, 19440, 27082, 34724, 42366, 50008, 57650 anti-HIV_Chain 4157 11799, 19441, 27083, 34725, 42367, 50009, 57651 anti-HIV_HeavyChain 4158 11800, 19442, 27084, 34726, 42368, 50010, 57652 anti-HIV_HeavyChain 4159 11801, 19443, 27085, 34727, 42369, 50011, 57653 anti-HIV_Chain 4160 11802, 19444, 27086, 34728, 42370, 50012, 57654 anti-HIV_Chain 4161 11803, 19445, 27087, 34729, 42371, 50013, 57655 anti-HIV_Chain 4162 11804, 19446, 27088, 34730, 42372, 50014, 57656 anti-HIV_Chain 4163 11805, 19447, 27089, 34731, 42373, 50015, 57657 anti-HIV_Chain 4164 11806, 19448, 27090, 34732, 42374, 50016, 57658 anti-HIV_Chain 4165 11807, 19449, 27091, 34733, 42375, 50017, 57659 anti-HIV_Chain 4166 11808, 19450, 27092, 34734, 42376, 50018, 57660 anti-HIV_Chain 4167 11809, 19451, 27093, 34735, 42377, 50019, 57661 anti-HIV_Chain 4168 11810, 19452, 27094, 34736, 42378, 50020, 57662 anti-HIV_Chain 4169 11811, 19453, 27095, 34737, 42379, 50021, 57663 anti-HIV_Chain 4170 11812, 19454, 27096, 34738, 42380, 50022, 57664 anti-HIV_Chain 4171 11813, 19455, 27097, 34739, 42381, 50023, 57665 anti-HIV_Chain 4172 11814, 19456, 27098, 34740, 42382, 50024, 57666 anti-HIV_Chain 4173 11815, 19457, 27099, 34741, 42383, 50025, 57667 anti-HIV_Chain 4174 11816, 19458, 27100, 34742, 42384, 50026, 57668 anti-HIV_Chain 4175 11817, 19459, 27101, 34743, 42385, 50027, 57669 anti-HIV_Chain 4176 11818, 19460, 27102, 34744, 42386, 50028, 57670 anti-HIV_Chain 4177 11819, 19461, 27103, 34745, 42387, 50029, 57671 anti-HIV_Chain 4178 11820, 19462, 27104, 34746, 42388, 50030, 57672 anti-HIV_Chain 4179 11821, 19463, 27105, 34747, 42389, 50031, 57673 anti-HIV_Chain 4180 11822, 19464, 27106, 34748, 42390, 50032, 57674 anti-HIV_Chain 4181 11823, 19465, 27107, 34749, 42391, 50033, 57675 anti-HIV_Chain 4182 11824, 19466, 27108, 34750, 42392, 50034, 57676 anti-HIV_Chain 4183 11825, 19467, 27109, 34751, 42393, 50035, 57677 anti-HIV_Chain 4184 11826, 19468, 27110, 34752, 42394, 50036, 57678 anti-HIV_Chain 4185 11827, 19469, 27111, 34753, 42395, 50037, 57679 anti-HIV_Chain 4186 11828, 19470, 27112, 34754, 42396, 50038, 57680 anti-HIV_Chain 4187 11829, 19471, 27113, 34755, 42397, 50039, 57681 anti-HIV_Chain 4188 11830, 19472, 27114, 34756, 42398, 50040, 57682 anti-HIV_Chain 4189 11831, 19473, 27115, 34757, 42399, 50041, 57683 anti-HIV_Chain 4190 11832, 19474, 27116, 34758, 42400, 50042, 57684 anti-HIV_Chain 4191 11833, 19475, 27117, 34759, 42401, 50043, 57685 anti-HIV_Chain 4192 11834, 19476, 27118, 34760, 42402, 50044, 57686 anti-HIV_Chain 4193 11835, 19477, 27119, 34761, 42403, 50045, 57687 anti-HIV_Chain 4194 11836, 19478, 27120, 34762, 42404, 50046, 57688 anti-HIV_Chain 4195 11837, 19479, 27121, 34763, 42405, 50047, 57689 anti-HIV_Chain 4196 11838, 19480, 27122, 34764, 42406, 50048, 57690 anti-HIV_Chain 4197 11839, 19481, 27123, 34765, 42407, 50049, 57691 anti-HIV_Chain 4198 11840, 19482, 27124, 34766, 42408, 50050, 57692 anti-HIV_Chain 4199 11841, 19483, 27125, 34767, 42409, 50051, 57693 anti-HIV_Chain 4200 11842, 19484, 27126, 34768, 42410, 50052, 57694 anti-HIV_Chain 4201 11843, 19485, 27127, 34769, 42411, 50053, 57695 anti-HIV_Chain 4202 11844, 19486, 27128, 34770, 42412, 50054, 57696 anti-HIV_Chain 4203 11845, 19487, 27129, 34771, 42413, 50055, 57697 anti-HIV_Chain 4204 11846, 19488, 27130, 34772, 42414, 50056, 57698 anti-HIV_Chain 4205 11847, 19489, 27131, 34773, 42415, 50057, 57699 anti-HIV_HeavyChain 4206 11848, 19490, 27132, 34774, 42416, 50058, 57700 anti-HIV_Chain 4207 11849, 19491, 27133, 34775, 42417, 50059, 57701 anti-HIV_Chain 4208 11850, 19492, 27134, 34776, 42418, 50060, 57702 anti-HIV_Chain 4209 11851, 19493, 27135, 34777, 42419, 50061, 57703 anti-HIV_Chain 4210 11852, 19494, 27136, 34778, 42420, 50062, 57704 anti-HIV_Chain 4211 11853, 19495, 27137, 34779, 42421, 50063, 57705 anti-HIV_Chain 4212 11854, 19496, 27138, 34780, 42422, 50064, 57706 anti-HIV_Chain 4213 11855, 19497, 27139, 34781, 42423, 50065, 57707 anti-HIV_Chain 4214 11856, 19498, 27140, 34782, 42424, 50066, 57708 anti-HIV_Chain 4215 11857, 19499, 27141, 34783, 42425, 50067, 57709 anti-HIV_Chain 4216 11858, 19500, 27142, 34784, 42426, 50068, 57710 anti-HIV_Chain 4217 11859, 19501, 27143, 34785, 42427, 50069, 57711 anti-HIV_Chain 4218 11860, 19502, 27144, 34786, 42428, 50070, 57712 anti-HIV_Chain 4219 11861, 19503, 27145, 34787, 42429, 50071, 57713 anti-HIV_Chain 4220 11862, 19504, 27146, 34788, 42430, 50072, 57714 anti-HIV_Chain 4221 11863, 19505, 27147, 34789, 42431, 50073, 57715 anti-HIV_Chain 4222 11864, 19506, 27148, 34790, 42432, 50074, 57716 anti-HIV_Chain 4223 11865, 19507, 27149, 34791, 42433, 50075, 57717 anti-HIV_Chain 4224 11866, 19508, 27150, 34792, 42434, 50076, 57718 anti-HIV_Chain 4225 11867, 19509, 27151, 34793, 42435, 50077, 57719 anti-HIV_Chain 4226 11868, 19510, 27152, 34794, 42436, 50078, 57720 anti-HIV_Chain 4227 11869, 19511, 27153, 34795, 42437, 50079, 57721 anti-HIV_Chain 4228 11870, 19512, 27154, 34796, 42438, 50080, 57722 anti-HIV_Chain 4229 11871, 19513, 27155, 34797, 42439, 50081, 57723 anti-HIV_Chain 4230 11872, 19514, 27156, 34798, 42440, 50082, 57724 anti-HIV_Chain 4231 11873, 19515, 27157, 34799, 42441, 50083, 57725 anti-HIV_Chain 4232 11874, 19516, 27158, 34800, 42442, 50084, 57726 anti-HIV_Chain 4233 11875, 19517, 27159, 34801, 42443, 50085, 57727 anti-HIV_Chain 4234 11876, 19518, 27160, 34802, 42444, 50086, 57728 anti-HIV_Chain 4235 11877, 19519, 27161, 34803, 42445, 50087, 57729 anti-HIV_Chain 4236 11878, 19520, 27162, 34804, 42446, 50088, 57730 anti-HIV_Chain 4237 11879, 19521, 27163, 34805, 42447, 50089, 57731 anti-HIV_Chain 4238 11880, 19522, 27164, 34806, 42448, 50090, 57732 anti-HIV_Chain 4239 11881, 19523, 27165, 34807, 42449, 50091, 57733 anti-HIV_Chain 4240 11882, 19524, 27166, 34808, 42450, 50092, 57734 anti-HIV_Chain 4241 11883, 19525, 27167, 34809, 42451, 50093, 57735 anti-HIV_Chain 4242 11884, 19526, 27168, 34810, 42452, 50094, 57736 anti-HIV_Chain 4243 11885, 19527, 27169, 34811, 42453, 50095, 57737 anti-HIV_Chain 4244 11886, 19528, 27170, 34812, 42454, 50096, 57738 anti-HIV_Chain 4245 11887, 19529, 27171, 34813, 42455, 50097, 57739 anti-HIV_Chain 4246 11888, 19530, 27172, 34814, 42456, 50098, 57740 anti-HIV_Chain 4247 11889, 19531, 27173, 34815, 42457, 50099, 57741 anti-HIV_Chain 4248 11890, 19532, 27174, 34816, 42458, 50100, 57742 anti-HIV_Chain 4249 11891, 19533, 27175, 34817, 42459, 50101, 57743 anti-HIV_Chain 4250 11892, 19534, 27176, 34818, 42460, 50102, 57744 anti-HIV_Chain 4251 11893, 19535, 27177, 34819, 42461, 50103, 57745 anti-HIV_Chain 4252 11894, 19536, 27178, 34820, 42462, 50104, 57746 anti-HIV_Chain 4253 11895, 19537, 27179, 34821, 42463, 50105, 57747 anti-HIV_Chain 4254 11896, 19538, 27180, 34822, 42464, 50106, 57748 anti-HIV_Chain 4255 11897, 19539, 27181, 34823, 42465, 50107, 57749 anti-HIV_Chain 4256 11898, 19540, 27182, 34824, 42466, 50108, 57750 anti-HIV_Chain 4257 11899, 19541, 27183, 34825, 42467, 50109, 57751 anti-HIV_Chain 4258 11900, 19542, 27184, 34826, 42468, 50110, 57752 anti-HIV_Chain 4259 11901, 19543, 27185, 34827, 42469, 50111, 57753 anti-HIV_Chain 4260 11902, 19544, 27186, 34828, 42470, 50112, 57754 anti-HIV_Chain 4261 11903, 19545, 27187, 34829, 42471, 50113, 57755 anti-HIV_Chain 4262 11904, 19546, 27188, 34830, 42472, 50114, 57756 anti-HIV_Chain 4263 11905, 19547, 27189, 34831, 42473, 50115, 57757 anti-HIV_Chain 4264 11906, 19548, 27190, 34832, 42474, 50116, 57758 anti-HIV_Chain 4265 11907, 19549, 27191, 34833, 42475, 50117, 57759 anti-HIV_Chain 4266 11908, 19550, 27192, 34834, 42476, 50118, 57760 anti-HIV_Chain 4267 11909, 19551, 27193, 34835, 42477, 50119, 57761 anti-HIV_Chain 4268 11910, 19552, 27194, 34836, 42478, 50120, 57762 anti-HIV_Chain 4269 11911, 19553, 27195, 34837, 42479, 50121, 57763 anti-HIV_Chain 4270 11912, 19554, 27196, 34838, 42480, 50122, 57764 anti-HIV_Chain 4271 11913, 19555, 27197, 34839, 42481, 50123, 57765 anti-HIV_Chain 4272 11914, 19556, 27198, 34840, 42482, 50124, 57766 anti-HIV_Chain 4273 11915, 19557, 27199, 34841, 42483, 50125, 57767 anti-HIV_Chain 4274 11916, 19558, 27200, 34842, 42484, 50126, 57768 anti-HIV_Chain 4275 11917, 19559, 27201, 34843, 42485, 50127, 57769 anti-HIV_Chain 4276 11918, 19560, 27202, 34844, 42486, 50128, 57770 anti-HIV_Chain 4277 11919, 19561, 27203, 34845, 42487, 50129, 57771 anti-HIV_Chain 4278 11920, 19562, 27204, 34846, 42488, 50130, 57772 anti-HIV_Chain 4279 11921, 19563, 27205, 34847, 42489, 50131, 57773 anti-HIV_Chain 4280 11922, 19564, 27206, 34848, 42490, 50132, 57774 anti-HIV_Chain 4281 11923, 19565, 27207, 34849, 42491, 50133, 57775 anti-HIV_Chain 4282 11924, 19566, 27208, 34850, 42492, 50134, 57776 anti-HIV_Chain 4283 11925, 19567, 27209, 34851, 42493, 50135, 57777 anti-HIV_Chain 4284 11926, 19568, 27210, 34852, 42494, 50136, 57778 anti-HIV_Chain 4285 11927, 19569, 27211, 34853, 42495, 50137, 57779 anti-HIV_Chain 4286 11928, 19570, 27212, 34854, 42496, 50138, 57780 anti-HIV_Chain 4287 11929, 19571, 27213, 34855, 42497, 50139, 57781 anti-HIV_Chain 4288 11930, 19572, 27214, 34856, 42498, 50140, 57782 anti-HIV_Chain 4289 11931, 19573, 27215, 34857, 42499, 50141, 57783 anti-HIV_Chain 4290 11932, 19574, 27216, 34858, 42500, 50142, 57784 anti-HIV_Chain 4291 11933, 19575, 27217, 34859, 42501, 50143, 57785 anti-HIV_Chain 4292 11934, 19576, 27218, 34860, 42502, 50144, 57786 anti-HIV_Chain 4293 11935, 19577, 27219, 34861, 42503, 50145, 57787 anti-HIV_Chain 4294 11936, 19578, 27220, 34862, 42504, 50146, 57788 anti-HIV_Chain 4295 11937, 19579, 27221, 34863, 42505, 50147, 57789 anti-HIV_Chain 4296 11938, 19580, 27222, 34864, 42506, 50148, 57790 anti-HIV_Chain 4297 11939, 19581, 27223, 34865, 42507, 50149, 57791 anti-HIV_Chain 4298 11940, 19582, 27224, 34866, 42508, 50150, 57792 anti-HIV_Chain 4299 11941, 19583, 27225, 34867, 42509, 50151, 57793 anti-HIV_Chain 4300 11942, 19584, 27226, 34868, 42510, 50152, 57794 anti-HIV_Chain 4301 11943, 19585, 27227, 34869, 42511, 50153, 57795 anti-HIV_Chain 4302 11944, 19586, 27228, 34870, 42512, 50154, 57796 anti-HIV_Chain 4303 11945, 19587, 27229, 34871, 42513, 50155, 57797 anti-HIV_Chain 4304 11946, 19588, 27230, 34872, 42514, 50156, 57798 anti-HIV_Chain 4305 11947, 19589, 27231, 34873, 42515, 50157, 57799 anti-HIV_Chain 4306 11948, 19590, 27232, 34874, 42516, 50158, 57800 anti-HIV_Chain 4307 11949, 19591, 27233, 34875, 42517, 50159, 57801 anti-HIV_Chain 4308 11950, 19592, 27234, 34876, 42518, 50160, 57802 anti-HIV_Chain 4309 11951, 19593, 27235, 34877, 42519, 50161, 57803 anti-HIV_Chain 4310 11952, 19594, 27236, 34878, 42520, 50162, 57804 anti-HIV_Chain 4311 11953, 19595, 27237, 34879, 42521, 50163, 57805 anti-HIV_Chain 4312 11954, 19596, 27238, 34880, 42522, 50164, 57806 anti-HIV_Chain 4313 11955, 19597, 27239, 34881, 42523, 50165, 57807 anti-HIV_Chain 4314 11956, 19598, 27240, 34882, 42524, 50166, 57808 anti-HIV_Chain 4315 11957, 19599, 27241, 34883, 42525, 50167, 57809 anti-HIV_Chain 4316 11958, 19600, 27242, 34884, 42526, 50168, 57810 anti-HIV_Chain 4317 11959, 19601, 27243, 34885, 42527, 50169, 57811 anti-HIV_Chain 4318 11960, 19602, 27244, 34886, 42528, 50170, 57812 anti-HIV_Chain 4319 11961, 19603, 27245, 34887, 42529, 50171, 57813 anti-HIV_Chain 4320 11962, 19604, 27246, 34888, 42530, 50172, 57814 anti-HIV_Chain 4321 11963, 19605, 27247, 34889, 42531, 50173, 57815 anti-HIV_Chain 4322 11964, 19606, 27248, 34890, 42532, 50174, 57816 anti-HIV_Chain 4323 11965, 19607, 27249, 34891, 42533, 50175, 57817 anti-HIV_Chain 4324 11966, 19608, 27250, 34892, 42534, 50176, 57818 anti-HIV_Chain 4325 11967, 19609, 27251, 34893, 42535, 50177, 57819 anti-HIV_Chain 4326 11968, 19610, 27252, 34894, 42536, 50178, 57820 anti-HIV_Chain 4327 11969, 19611, 27253, 34895, 42537, 50179, 57821 anti-HIV_Chain 4328 11970, 19612, 27254, 34896, 42538, 50180, 57822 anti-HIV_Chain 4329 11971, 19613, 27255, 34897, 42539, 50181, 57823 anti-HIV_Chain 4330 11972, 19614, 27256, 34898, 42540, 50182, 57824 anti-HIV_Chain 4331 11973, 19615, 27257, 34899, 42541, 50183, 57825 anti-HIV_Chain 4332 11974, 19616, 27258, 34900, 42542, 50184, 57826 anti-HIV_Chain 4333 11975, 19617, 27259, 34901, 42543, 50185, 57827 anti-HIV_Chain 4334 11976, 19618, 27260, 34902, 42544, 50186, 57828 anti-HIV_Chain 4335 11977, 19619, 27261, 34903, 42545, 50187, 57829 anti-HIV_Chain 4336 11978, 19620, 27262, 34904, 42546, 50188, 57830 anti-HIV_Chain 4337 11979, 19621, 27263, 34905, 42547, 50189, 57831 anti-HIV_Chain 4338 11980, 19622, 27264, 34906, 42548, 50190, 57832 anti-HIV_Chain 4339 11981, 19623, 27265, 34907, 42549, 50191, 57833 anti-HIV_Chain 4340 11982, 19624, 27266, 34908, 42550, 50192, 57834 anti-HIV_Chain 4341 11983, 19625, 27267, 34909, 42551, 50193, 57835 anti-HIV_Chain 4342 11984, 19626, 27268, 34910, 42552, 50194, 57836 anti-HIV_Chain 4343 11985, 19627, 27269, 34911, 42553, 50195, 57837 anti-HIV_Chain 4344 11986, 19628, 27270, 34912, 42554, 50196, 57838 anti-HIV_Chain 4345 11987, 19629, 27271, 34913, 42555, 50197, 57839 anti-HIV_Chain 4346 11988, 19630, 27272, 34914, 42556, 50198, 57840 anti-HIV_Chain 4347 11989, 19631, 27273, 34915, 42557, 50199, 57841 anti-HIV_Chain 4348 11990, 19632, 27274, 34916, 42558, 50200, 57842 anti-HIV_Chain 4349 11991, 19633, 27275, 34917, 42559, 50201, 57843 anti-HIV_Chain 4350 11992, 19634, 27276, 34918, 42560, 50202, 57844 anti-HIV_Chain 4351 11993, 19635, 27277, 34919, 42561, 50203, 57845 anti-HIV_Chain 4352 11994, 19636, 27278, 34920, 42562, 50204, 57846 anti-HIV_Chain 4353 11995, 19637, 27279, 34921, 42563, 50205, 57847 anti-HIV_Chain 4354 11996, 19638, 27280, 34922, 42564, 50206, 57848 anti-HIV_Chain 4355 11997, 19639, 27281, 34923, 42565, 50207, 57849 anti-HIV_Chain 4356 11998, 19640, 27282, 34924, 42566, 50208, 57850 anti-HIV_Chain 4357 11999, 19641, 27283, 34925, 42567, 50209, 57851 anti-HIV_Chain 4358 12000, 19642, 27284, 34926, 42568, 50210, 57852 anti-HIV_Chain 4359 12001, 19643, 27285, 34927, 42569, 50211, 57853 anti-HIV_Chain 4360 12002, 19644, 27286, 34928, 42570, 50212, 57854 anti-HIV_Chain 4361 12003, 19645, 27287, 34929, 42571, 50213, 57855 anti-HIV_Chain 4362 12004, 19646, 27288, 34930, 42572, 50214, 57856 anti-HIV_Chain 4363 12005, 19647, 27289, 34931, 42573, 50215, 57857 anti-HIV_Chain 4364 12006, 19648, 27290, 34932, 42574, 50216, 57858 anti-HIV_Chain 4365 12007, 19649, 27291, 34933, 42575, 50217, 57859 anti-HIV_Chain 4366 12008, 19650, 27292, 34934, 42576, 50218, 57860 anti-HIV_Chain 4367 12009, 19651, 27293, 34935, 42577, 50219, 57861 anti-HIV_Chain 4368 12010, 19652, 27294, 34936, 42578, 50220, 57862 anti-HIV_Chain 4369 12011, 19653, 27295, 34937, 42579, 50221, 57863 anti-HIV_Chain 4370 12012, 19654, 27296, 34938, 42580, 50222, 57864 anti-HIV_Chain 4371 12013, 19655, 27297, 34939, 42581, 50223, 57865 anti-HIV_Chain 4372 12014, 19656, 27298, 34940, 42582, 50224, 57866 anti-HIV_Chain 4373 12015, 19657, 27299, 34941, 42583, 50225, 57867 anti-HIV_Chain 4374 12016, 19658, 27300, 34942, 42584, 50226, 57868 anti-HIV_Chain 4375 12017, 19659, 27301, 34943, 42585, 50227, 57869 anti-HIV_Chain 4376 12018, 19660, 27302, 34944, 42586, 50228, 57870 anti-HIV_Chain 4377 12019, 19661, 27303, 34945, 42587, 50229, 57871 anti-HIV_Chain 4378 12020, 19662, 27304, 34946, 42588, 50230, 57872 anti-HIV_Chain 4379 12021, 19663, 27305, 34947, 42589, 50231, 57873 anti-HIV_Chain 4380 12022, 19664, 27306, 34948, 42590, 50232, 57874 anti-HIV_Chain 4381 12023, 19665, 27307, 34949, 42591, 50233, 57875 anti-HIV_Chain 4382 12024, 19666, 27308, 34950, 42592, 50234, 57876 anti-HIV_Chain 4383 12025, 19667, 27309, 34951, 42593, 50235, 57877 anti-HIV_Chain 4384 12026, 19668, 27310, 34952, 42594, 50236, 57878 anti-HIV_Chain 4385 12027, 19669, 27311, 34953, 42595, 50237, 57879 anti-HIV_Chain 4386 12028, 19670, 27312, 34954, 42596, 50238, 57880 anti-HIV_Chain 4387 12029, 19671, 27313, 34955, 42597, 50239, 57881 anti-HIV_Chain 4388 12030, 19672, 27314, 34956, 42598, 50240, 57882 anti-HIV_Chain 4389 12031, 19673, 27315, 34957, 42599, 50241, 57883 anti-HIV_Chain 4390 12032, 19674, 27316, 34958, 42600, 50242, 57884 anti-HIV_Chain 4391 12033, 19675, 27317, 34959, 42601, 50243, 57885 anti-HIV_Chain 4392 12034, 19676, 27318, 34960, 42602, 50244, 57886 anti-HIV_Chain 4393 12035, 19677, 27319, 34961, 42603, 50245, 57887 anti-HIV_Chain 4394 12036, 19678, 27320, 34962, 42604, 50246, 57888 anti-HIV_Chain 4395 12037, 19679, 27321, 34963, 42605, 50247, 57889 anti-HIV_Chain 4396 12038, 19680, 27322, 34964, 42606, 50248, 57890 anti-HIV_Chain 4397 12039, 19681, 27323, 34965, 42607, 50249, 57891 anti-HIV_Chain 4398 12040, 19682, 27324, 34966, 42608, 50250, 57892 anti-HIV_Chain 4399 12041, 19683, 27325, 34967, 42609, 50251, 57893 anti-HIV_Chain 4400 12042, 19684, 27326, 34968, 42610, 50252, 57894 anti-HIV_Chain 4401 12043, 19685, 27327, 34969, 42611, 50253, 57895 anti-HIV_Chain 4402 12044, 19686, 27328, 34970, 42612, 50254, 57896 anti-HIV_Chain 4403 12045, 19687, 27329, 34971, 42613, 50255, 57897 anti-HIV_Chain 4404 12046, 19688, 27330, 34972, 42614, 50256, 57898 anti-HIV_Chain 4405 12047, 19689, 27331, 34973, 42615, 50257, 57899 anti-HIV_Chain 4406 12048, 19690, 27332, 34974, 42616, 50258, 57900 anti-HIV_Chain 4407 12049, 19691, 27333, 34975, 42617, 50259, 57901 anti-HIV_Chain 4408 12050, 19692, 27334, 34976, 42618, 50260, 57902 anti-HIV_Chain 4409 12051, 19693, 27335, 34977, 42619, 50261, 57903 anti-HIV_Chain 4410 12052, 19694, 27336, 34978, 42620, 50262, 57904 anti-HIV_Chain 4411 12053, 19695, 27337, 34979, 42621, 50263, 57905 anti-HIV_Chain 4412 12054, 19696, 27338, 34980, 42622, 50264, 57906 anti-HIV_Chain 4413 12055, 19697, 27339, 34981, 42623, 50265, 57907 anti-HIV_Chain 4414 12056, 19698, 27340, 34982, 42624, 50266, 57908 anti-HIV_Chain 4415 12057, 19699, 27341, 34983, 42625, 50267, 57909 anti-HIV_Chain 4416 12058, 19700, 27342, 34984, 42626, 50268, 57910 anti-HIV_Chain 4417 12059, 19701, 27343, 34985, 42627, 50269, 57911 anti-HIV_Chain 4418 12060, 19702, 27344, 34986, 42628, 50270, 57912 anti-HIV_Chain 4419 12061, 19703, 27345, 34987, 42629, 50271, 57913 anti-HIV_Chain 4420 12062, 19704, 27346, 34988, 42630, 50272, 57914 anti-HIV_Chain 4421 12063, 19705, 27347, 34989, 42631, 50273, 57915 anti-HIV_Chain 4422 12064, 19706, 27348, 34990, 42632, 50274, 57916 anti-HIV_Chain 4423 12065, 19707, 27349, 34991, 42633, 50275, 57917 anti-HIV_Chain 4424 12066, 19708, 27350, 34992, 42634, 50276, 57918 anti-HIV_Chain 4425 12067, 19709, 27351, 34993, 42635, 50277, 57919 anti-HIV_Chain 4426 12068, 19710, 27352, 34994, 42636, 50278, 57920 anti-HIV_Chain 4427 12069, 19711, 27353, 34995, 42637, 50279, 57921 anti-HIV_Chain 4428 12070, 19712, 27354, 34996, 42638, 50280, 57922 anti-HIV_Chain 4429 12071, 19713, 27355, 34997, 42639, 50281, 57923 anti-HIV_Chain 4430 12072, 19714, 27356, 34998, 42640, 50282, 57924 anti-HIV_Chain 4431 12073, 19715, 27357, 34999, 42641, 50283, 57925 anti-HIV_Chain 4432 12074, 19716, 27358, 35000, 42642, 50284, 57926 anti-HIV_Chain 4433 12075, 19717, 27359, 35001, 42643, 50285, 57927 anti-HIV_Chain 4434 12076, 19718, 27360, 35002, 42644, 50286, 57928 anti-HIV_Chain 4435 12077, 19719, 27361, 35003, 42645, 50287, 57929 anti-HIV_Chain 4436 12078, 19720, 27362, 35004, 42646, 50288, 57930 anti-HIV_Chain 4437 12079, 19721, 27363, 35005, 42647, 50289, 57931 anti-HIV_Chain 4438 12080, 19722, 27364, 35006, 42648, 50290, 57932 anti-HIV_Chain 4439 12081, 19723, 27365, 35007, 42649, 50291, 57933 anti-HIV_Chain 4440 12082, 19724, 27366, 35008, 42650, 50292, 57934 anti-HIV_Chain 4441 12083, 19725, 27367, 35009, 42651, 50293, 57935 anti-HIV_Chain 4442 12084, 19726, 27368, 35010, 42652, 50294, 57936 anti-HIV_Chain 4443 12085, 19727, 27369, 35011, 42653, 50295, 57937 anti-HIV_Chain 4444 12086, 19728, 27370, 35012, 42654, 50296, 57938 anti-HIV_Chain 4445 12087, 19729, 27371, 35013, 42655, 50297, 57939 anti-HIV_Chain 4446 12088, 19730, 27372, 35014, 42656, 50298, 57940 anti-HIV_Chain 4447 12089, 19731, 27373, 35015, 42657, 50299, 57941 anti-HIV_Chain 4448 12090, 19732, 27374, 35016, 42658, 50300, 57942 anti-HIV_Chain 4449 12091, 19733, 27375, 35017, 42659, 50301, 57943 anti-HIV_Chain 4450 12092, 19734, 27376, 35018, 42660, 50302, 57944 anti-HIV_Chain 4451 12093, 19735, 27377, 35019, 42661, 50303, 57945 anti-HIV_Chain 4452 12094, 19736, 27378, 35020, 42662, 50304, 57946 anti-HIV_Chain 4453 12095, 19737, 27379, 35021, 42663, 50305, 57947 anti-HIV_Chain 4454 12096, 19738, 27380, 35022, 42664, 50306, 57948 anti-HIV_Chain 4455 12097, 19739, 27381, 35023, 42665, 50307, 57949 anti-HIV_Chain 4456 12098, 19740, 27382, 35024, 42666, 50308, 57950 anti-HIV_Chain 4457 12099, 19741, 27383, 35025, 42667, 50309, 57951 anti-HIV_Chain 4458 12100, 19742, 27384, 35026, 42668, 50310, 57952 anti-HIV_Chain 4459 12101, 19743, 27385, 35027, 42669, 50311, 57953 anti-HIV_Chain 4460 12102, 19744, 27386, 35028, 42670, 50312, 57954 anti-HIV_Chain 4461 12103, 19745, 27387, 35029, 42671, 50313, 57955 anti-HIV_Chain 4462 12104, 19746, 27388, 35030, 42672, 50314, 57956 anti-HIV_Chain 4463 12105, 19747, 27389, 35031, 42673, 50315, 57957 anti-HIV_Chain 4464 12106, 19748, 27390, 35032, 42674, 50316, 57958 anti-HIV_Chain 4465 12107, 19749, 27391, 35033, 42675, 50317, 57959 anti-HIV_Chain 4466 12108, 19750, 27392, 35034, 42676, 50318, 57960 anti-HIV_Chain 4467 12109, 19751, 27393, 35035, 42677, 50319, 57961 anti-HIV_Chain 4468 12110, 19752, 27394, 35036, 42678, 50320, 57962 anti-HIV_Chain 4469 12111, 19753, 27395, 35037, 42679, 50321, 57963 anti-HIV_Chain 4470 12112, 19754, 27396, 35038, 42680, 50322, 57964 anti-HIV_Chain 4471 12113, 19755, 27397, 35039, 42681, 50323, 57965 anti-HIV_LightChain 4472 12114, 19756, 27398, 35040, 42682, 50324, 57966 anti-HIV_Chain 4473 12115, 19757, 27399, 35041, 42683, 50325, 57967 anti-HIV_Chain 4474 12116, 19758, 27400, 35042, 42684, 50326, 57968 anti-HIV_Chain 4475 12117, 19759, 27401, 35043, 42685, 50327, 57969 anti-HIV_Chain 4476 12118, 19760, 27402, 35044, 42686, 50328, 57970 anti-HIV_Chain 4477 12119, 19761, 27403, 35045, 42687, 50329, 57971 anti-HIV_Chain 4478 12120, 19762, 27404, 35046, 42688, 50330, 57972 anti-HIV_Chain 4479 12121, 19763, 27405, 35047, 42689, 50331, 57973 anti-HIV_Chain 4480 12122, 19764, 27406, 35048, 42690, 50332, 57974 anti-HIV_Chain 4481 12123, 19765, 27407, 35049, 42691, 50333, 57975 anti-HIV_Chain 4482 12124, 19766, 27408, 35050, 42692, 50334, 57976 anti-HIV_Chain 4483 12125, 19767, 27409, 35051, 42693, 50335, 57977 anti-HIV_Chain 4484 12126, 19768, 27410, 35052, 42694, 50336, 57978 anti-HIV_Chain 4485 12127, 19769, 27411, 35053, 42695, 50337, 57979 anti-HIV_Chain 4486 12128, 19770, 27412, 35054, 42696, 50338, 57980 anti-HIV_Chain 4487 12129, 19771, 27413, 35055, 42697, 50339, 57981 anti-HIV_Chain 4488 12130, 19772, 27414, 35056, 42698, 50340, 57982 anti-HIV_Chain 4489 12131, 19773, 27415, 35057, 42699, 50341, 57983 anti-HIV_Chain 4490 12132, 19774, 27416, 35058, 42700, 50342, 57984 anti-HIV_Chain 4491 12133, 19775, 27417, 35059, 42701, 50343, 57985 anti-HIV_Chain 4492 12134, 19776, 27418, 35060, 42702, 50344, 57986 anti-HIV_Chain 4493 12135, 19777, 27419, 35061, 42703, 50345, 57987 anti-HIV_Chain 4494 12136, 19778, 27420, 35062, 42704, 50346, 57988 anti-HIV_Chain 4495 12137, 19779, 27421, 35063, 42705, 50347, 57989 anti-HIV_Chain 4496 12138, 19780, 27422, 35064, 42706, 50348, 57990 anti-HIV_Chain 4497 12139, 19781, 27423, 35065, 42707, 50349, 57991 anti-HIV_Chain 4498 12140, 19782, 27424, 35066, 42708, 50350, 57992 anti-HIV_Chain 4499 12141, 19783, 27425, 35067, 42709, 50351, 57993 anti-HIV_Chain 4500 12142, 19784, 27426, 35068, 42710, 50352, 57994 anti-HIV_Chain 4501 12143, 19785, 27427, 35069, 42711, 50353, 57995 anti-HIV_Chain 4502 12144, 19786, 27428, 35070, 42712, 50354, 57996 anti-HIV_Chain 4503 12145, 19787, 27429, 35071, 42713, 50355, 57997 anti-HIV_Chain 4504 12146, 19788, 27430, 35072, 42714, 50356, 57998 anti-HIV_Chain 4505 12147, 19789, 27431, 35073, 42715, 50357, 57999 anti-HIV_Chain 4506 12148, 19790, 27432, 35074, 42716, 50358, 58000 anti-HIV_Chain 4507 12149, 19791, 27433, 35075, 42717, 50359, 58001 anti-HIV_Chain 4508 12150, 19792, 27434, 35076, 42718, 50360, 58002 anti-HIV_Chain 4509 12151, 19793, 27435, 35077, 42719, 50361, 58003 anti-HIV_Chain 4510 12152, 19794, 27436, 35078, 42720, 50362, 58004 anti-HIV_Chain 4511 12153, 19795, 27437, 35079, 42721, 50363, 58005 anti-HIV_Chain 4512 12154, 19796, 27438, 35080, 42722, 50364, 58006 anti-HIV_Chain 4513 12155, 19797, 27439, 35081, 42723, 50365, 58007 anti-HIV_Chain 4514 12156, 19798, 27440, 35082, 42724, 50366, 58008 anti-HIV_Chain 4515 12157, 19799, 27441, 35083, 42725, 50367, 58009 anti-HIV_Chain 4516 12158, 19800, 27442, 35084, 42726, 50368, 58010 anti-HIV_Chain 4517 12159, 19801, 27443, 35085, 42727, 50369, 58011 anti-HIV_Chain 4518 12160, 19802, 27444, 35086, 42728, 50370, 58012 anti-HIV_Chain 4519 12161, 19803, 27445, 35087, 42729, 50371, 58013 anti-HIV_Chain 4520 12162, 19804, 27446, 35088, 42730, 50372, 58014 anti-HIV_Chain 4521 12163, 19805, 27447, 35089, 42731, 50373, 58015 anti-HIV_Chain 4522 12164, 19806, 27448, 35090, 42732, 50374, 58016 anti-HIV_Chain 4523 12165, 19807, 27449, 35091, 42733, 50375, 58017 anti-HIV_Chain 4524 12166, 19808, 27450, 35092, 42734, 50376, 58018 anti-HIV_Chain 4525 12167, 19809, 27451, 35093, 42735, 50377, 58019 anti-HIV_Chain 4526 12168, 19810, 27452, 35094, 42736, 50378, 58020 anti-HIV_Chain 4527 12169, 19811, 27453, 35095, 42737, 50379, 58021 anti-HIV_Chain 4528 12170, 19812, 27454, 35096, 42738, 50380, 58022 anti-HIV_Chain 4529 12171, 19813, 27455, 35097, 42739, 50381, 58023 anti-HIV_Chain 4530 12172, 19814, 27456, 35098, 42740, 50382, 58024 anti-HIV_Chain 4531 12173, 19815, 27457, 35099, 42741, 50383, 58025 anti-HIV_Chain 4532 12174, 19816, 27458, 35100, 42742, 50384, 58026 anti-HIV_Chain 4533 12175, 19817, 27459, 35101, 42743, 50385, 58027 anti-HIV_Chain 4534 12176, 19818, 27460, 35102, 42744, 50386, 58028 anti-HIV_Chain 4535 12177, 19819, 27461, 35103, 42745, 50387, 58029 anti-HIV_Chain 4536 12178, 19820, 27462, 35104, 42746, 50388, 58030 anti-HIV_Chain 4537 12179, 19821, 27463, 35105, 42747, 50389, 58031 anti-HIV_Chain 4538 12180, 19822, 27464, 35106, 42748, 50390, 58032 anti-HIV_Chain 4539 12181, 19823, 27465, 35107, 42749, 50391, 58033 anti-HIV_Chain 4540 12182, 19824, 27466, 35108, 42750, 50392, 58034 anti-HIV_Chain 4541 12183, 19825, 27467, 35109, 42751, 50393, 58035 anti-HIV_Chain 4542 12184, 19826, 27468, 35110, 42752, 50394, 58036 anti-HIV_LightChain 4543 12185, 19827, 27469, 35111, 42753, 50395, 58037 anti-HIV_Chain 4544 12186, 19828, 27470, 35112, 42754, 50396, 58038 anti-HIV_Chain 4545 12187, 19829, 27471, 35113, 42755, 50397, 58039 anti-HIV_Chain 4546 12188, 19830, 27472, 35114, 42756, 50398, 58040 anti-HIV_Chain 4547 12189, 19831, 27473, 35115, 42757, 50399, 58041 anti-HIV_Chain 4548 12190, 19832, 27474, 35116, 42758, 50400, 58042 anti-HIV_Chain 4549 12191, 19833, 27475, 35117, 42759, 50401, 58043 anti-HIV_Chain 4550 12192, 19834, 27476, 35118, 42760, 50402, 58044 anti-HIV_Chain 4551 12193, 19835, 27477, 35119, 42761, 50403, 58045 anti-HIV_Chain 4552 12194, 19836, 27478, 35120, 42762, 50404, 58046 anti-HIV_Chain 4553 12195, 19837, 27479, 35121, 42763, 50405, 58047 anti-HIV_Chain 4554 12196, 19838, 27480, 35122, 42764, 50406, 58048 anti-HIV_Chain 4555 12197, 19839, 27481, 35123, 42765, 50407, 58049 anti-HIV_Chain 4556 12198, 19840, 27482, 35124, 42766, 50408, 58050 anti-HIV_Chain 4557 12199, 19841, 27483, 35125, 42767, 50409, 58051 anti-HIV_Chain 4558 12200, 19842, 27484, 35126, 42768, 50410, 58052 anti-HIV_Chain 4559 12201, 19843, 27485, 35127, 42769, 50411, 58053 anti-HIV_Chain 4560 12202, 19844, 27486, 35128, 42770, 50412, 58054 anti-HIV_Chain 4561 12203, 19845, 27487, 35129, 42771, 50413, 58055 anti-HIV_Chain 4562 12204, 19846, 27488, 35130, 42772, 50414, 58056 anti-HIV_HeavyChain 4563 12205, 19847, 27489, 35131, 42773, 50415, 58057 anti-HIV_HeavyChain 4564 12206, 19848, 27490, 35132, 42774, 50416, 58058 anti-HIV_HeavyChain 4565 12207, 19849, 27491, 35133, 42775, 50417, 58059 anti-HIV_Chain 4566 12208, 19850, 27492, 35134, 42776, 50418, 58060 anti-HIV_Chain 4567 12209, 19851, 27493, 35135, 42777, 50419, 58061 anti-HIV_Chain 4568 12210, 19852, 27494, 35136, 42778, 50420, 58062 anti-HIV_Chain 4569 12211, 19853, 27495, 35137, 42779, 50421, 58063 anti-HIV_Chain 4570 12212, 19854, 27496, 35138, 42780, 50422, 58064 anti-HIV_Chain 4571 12213, 19855, 27497, 35139, 42781, 50423, 58065 anti-HIV_Chain 4572 12214, 19856, 27498, 35140, 42782, 50424, 58066 anti-HIV_Chain 4573 12215, 19857, 27499, 35141, 42783, 50425, 58067 anti-HIV_Chain 4574 12216, 19858, 27500, 35142, 42784, 50426, 58068 anti-HIV_HeavyChain 4575 12217, 19859, 27501, 35143, 42785, 50427, 58069 anti-HIV_HeavyChain 4576 12218, 19860, 27502, 35144, 42786, 50428, 58070 anti-HIV_HeavyChain 4577 12219, 19861, 27503, 35145, 42787, 50429, 58071 anti-HIV_HeavyChain 4578 12220, 19862, 27504, 35146, 42788, 50430, 58072 anti-HIV_HeavyChain 4579 12221, 19863, 27505, 35147, 42789, 50431, 58073 anti-HIV_HeavyChain 4580 12222, 19864, 27506, 35148, 42790, 50432, 58074 anti-HIV_HeavyChain 4581 12223, 19865, 27507, 35149, 42791, 50433, 58075 anti-HIV_HeavyChain 4582 12224, 19866, 27508, 35150, 42792, 50434, 58076 anti-HIV_HeavyChain 4583 12225, 19867, 27509, 35151, 42793, 50435, 58077 anti-HIV_HeavyChain 4584 12226, 19868, 27510, 35152, 42794, 50436, 58078 anti-HIV_HeavyChain 4585 12227, 19869, 27511, 35153, 42795, 50437, 58079 anti-HIV_HeavyChain 4586 12228, 19870, 27512, 35154, 42796, 50438, 58080 anti-HIV_HeavyChain 4587 12229, 19871, 27513, 35155, 42797, 50439, 58081 anti-HIV_Chain 4588 12230, 19872, 27514, 35156, 42798, 50440, 58082 anti-HIV_Chain 4589 12231, 19873, 27515, 35157, 42799, 50441, 58083 anti-HIV_Chain 4590 12232, 19874, 27516, 35158, 42800, 50442, 58084 anti-HIV_Chain 4591 12233, 19875, 27517, 35159, 42801, 50443, 58085 anti-HIV_Chain 4592 12234, 19876, 27518, 35160, 42802, 50444, 58086 anti-HIV_Chain 4593 12235, 19877, 27519, 35161, 42803, 50445, 58087 anti-HIV_Chain 4594 12236, 19878, 27520, 35162, 42804, 50446, 58088 anti-HIV_Chain 4595 12237, 19879, 27521, 35163, 42805, 50447, 58089 anti-HIV_Chain 4596 12238, 19880, 27522, 35164, 42806, 50448, 58090 anti-HIV_Chain 4597 12239, 19881, 27523, 35165, 42807, 50449, 58091 anti-HIV_Chain 4598 12240, 19882, 27524, 35166, 42808, 50450, 58092 anti-HIV_Chain 4599 12241, 19883, 27525, 35167, 42809, 50451, 58093 anti-HIV_Chain 4600 12242, 19884, 27526, 35168, 42810, 50452, 58094 anti-HIV_Chain 4601 12243, 19885, 27527, 35169, 42811, 50453, 58095 anti-HIV_Chain 4602 12244, 19886, 27528, 35170, 42812, 50454, 58096 anti-HIV_Chain 4603 12245, 19887, 27529, 35171, 42813, 50455, 58097 anti-HIV_Chain 4604 12246, 19888, 27530, 35172, 42814, 50456, 58098 anti-HIV_Chain 4605 12247, 19889, 27531, 35173, 42815, 50457, 58099 anti-HIV_Chain 4606 12248, 19890, 27532, 35174, 42816, 50458, 58100 anti-HIV_HeavyChain 4607 12249, 19891, 27533, 35175, 42817, 50459, 58101 anti-HIV_HeavyChain 4608 12250, 19892, 27534, 35176, 42818, 50460, 58102 anti-HIV_Chain 4609 12251, 19893, 27535, 35177, 42819, 50461, 58103 anti-HIV_Chain 4610 12252, 19894, 27536, 35178, 42820, 50462, 58104 anti-HIV_Chain 4611 12253, 19895, 27537, 35179, 42821, 50463, 58105 anti-HIV_Chain 4612 12254, 19896, 27538, 35180, 42822, 50464, 58106 anti-HIV_Chain 4613 12255, 19897, 27539, 35181, 42823, 50465, 58107 anti-HIV_Chain 4614 12256, 19898, 27540, 35182, 42824, 50466, 58108 anti-HIV_HeavyChain 4615 12257, 19899, 27541, 35183, 42825, 50467, 58109 anti-HIV_HeavyChain 4616 12258, 19900, 27542, 35184, 42826, 50468, 58110 anti-HIV_Chain 4617 12259, 19901, 27543, 35185, 42827, 50469, 58111 anti-HIV_Chain 4618 12260, 19902, 27544, 35186, 42828, 50470, 58112 anti-HIV_Chain 4619 12261, 19903, 27545, 35187, 42829, 50471, 58113 anti-HIV_Chain 4620 12262, 19904, 27546, 35188, 42830, 50472, 58114 anti-HIV_Chain 4621 12263, 19905, 27547, 35189, 42831, 50473, 58115 anti-HIV_Chain 4622 12264, 19906, 27548, 35190, 42832, 50474, 58116 anti-HIV_Chain 4623 12265, 19907, 27549, 35191, 42833, 50475, 58117 anti-HIV_Chain 4624 12266, 19908, 27550, 35192, 42834, 50476, 58118 anti-HIV_LightChain 4625 12267, 19909, 27551, 35193, 42835, 50477, 58119 anti-HIV_Chain 4626 12268, 19910, 27552, 35194, 42836, 50478, 58120 anti-HIV_Chain 4627 12269, 19911, 27553, 35195, 42837, 50479, 58121 anti-HIV_SingleChain 4628 12270, 19912, 27554, 35196, 42838, 50480, 58122 anti-HIV_LightChain 4629 12271, 19913, 27555, 35197, 42839, 50481, 58123 anti-HIV_Chain 4630 12272, 19914, 27556, 35198, 42840, 50482, 58124 anti-HIV_Chain 4631 12273, 19915, 27557, 35199, 42841, 50483, 58125 anti-influenza_Fab 4632 12274, 19916, 27558, 35200, 42842, 50484, 58126 anti-influenza_Fab 4633 12275, 19917, 27559, 35201, 42843, 50485, 58127 anti-influenza_Fab 4634 12276, 19918, 27560, 35202, 42844, 50486, 58128 anti-influenza_Fab 4635 12277, 19919, 27561, 35203, 42845, 50487, 58129 anti-influenza_Fab 4636 12278, 19920, 27562, 35204, 42846, 50488, 58130 anti-influenza_Fab 4637 12279, 19921, 27563, 35205, 42847, 50489, 58131 anti-influenza_Fab 4638 12280, 19922, 27564, 35206, 42848, 50490, 58132 anti-influenza_Apo 4639 12281, 19923, 27565, 35207, 42849, 50491, 58133 anti-influenza_Apo 4640 12282, 19924, 27566, 35208, 42850, 50492, 58134 anti-influenza-A_kappa_LightChain_V-Region 4641 12283, 19925, 27567, 35209, 42851, 50493, 58135 anti-influenza-A_kappa_LightChain_V-Region 4642 12284, 19926, 27568, 35210, 42852, 50494, 58136 anti-influenza-A_kappa_LightChain_V-Region 4643 12285, 19927, 27569, 35211, 42853, 50495, 58137 anti-influenza-A_kappa_LightChain_V-Region 4644 12286, 19928, 27570, 35212, 42854, 50496, 58138 anti-influenza-A_kappa_LightChain_V-Region 4645 12287, 19929, 27571, 35213, 42855, 50497, 58139 anti-influenza-A_kappa_LightChain_V-Region 4646 12288, 19930, 27572, 35214, 42856, 50498, 58140 anti-influenza-A_HeavyChain_V-Region 4647 12289, 19931, 27573, 35215, 42857, 50499, 58141 anti-influenza-A_HeavyChain_V-Region 4648 12290, 19932, 27574, 35216, 42858, 50500, 58142 anti-influenza-A_HeavyChain_V-Region 4649 12291, 19933, 27575, 35217, 42859, 50501, 58143 anti-influenza-A_HeavyChain_V-Region 4650 12292, 19934, 27576, 35218, 42860, 50502, 58144 anti-influenza-A_HeavyChain_V-Region 4651 12293, 19935, 27577, 35219, 42861, 50503, 58145 anti-influenza-A_HeavyChain_V-Region 4652 12294, 19936, 27578, 35220, 42862, 50504, 58146 anti-influenza-A_HeavyChain_V-Region 4653 12295, 19937, 27579, 35221, 42863, 50505, 58147 anti-influenza-A_LightChain_V-Region 4654 12296, 19938, 27580, 35222, 42864, 50506, 58148 anti-influenza-A_HeavyChain_V-Region 4655 12297, 19939, 27581, 35223, 42865, 50507, 58149 anti-influenza_Chain 4656 12298, 19940, 27582, 35224, 42866, 50508, 58150 anti-influenza_Chain 4657 12299, 19941, 27583, 35225, 42867, 50509, 58151 anti-influenza_Chain 4658 12300, 19942, 27584, 35226, 42868, 50510, 58152 anti-influenza_Chain 4659 12301, 19943, 27585, 35227, 42869, 50511, 58153 anti-influenza_Chain 4660 12302, 19944, 27586, 35228, 42870, 50512, 58154 anti-influenza_Chain 4661 12303, 19945, 27587, 35229, 42871, 50513, 58155 anti-influenza_Chain 4662 12304, 19946, 27588, 35230, 42872, 50514, 58156 anti-influenza_Chain 4663 12305, 19947, 27589, 35231, 42873, 50515, 58157 anti-influenza_Chain 4664 12306, 19948, 27590, 35232, 42874, 50516, 58158 anti-influenza_Chain 4665 12307, 19949, 27591, 35233, 42875, 50517, 58159 anti-influenza_Chain 4666 12308, 19950, 27592, 35234, 42876, 50518, 58160 anti-influenza_Chain 4667 12309, 19951, 27593, 35235, 42877, 50519, 58161 anti-influenza_Chain 4668 12310, 19952, 27594, 35236, 42878, 50520, 58162 anti-influenza_Chain 4669 12311, 19953, 27595, 35237, 42879, 50521, 58163 anti-influenza_Chain 4670 12312, 19954, 27596, 35238, 42880, 50522, 58164 anti-influenza_Chain 4671 12313, 19955, 27597, 35239, 42881, 50523, 58165 anti-influenza_Chain 4672 12314, 19956, 27598, 35240, 42882, 50524, 58166 anti-influenza_Chain 4673 12315, 19957, 27599, 35241, 42883, 50525, 58167 anti-influenza_Chain 4674 12316, 19958, 27600, 35242, 42884, 50526, 58168 anti-influenza_Chain 4675 12317, 19959, 27601, 35243, 42885, 50527, 58169 anti-influenza_Chain 4676 12318, 19960, 27602, 35244, 42886, 50528, 58170 anti-influenza_Chain 4677 12319, 19961, 27603, 35245, 42887, 50529, 58171 anti-influenza_Chain 4678 12320, 19962, 27604, 35246, 42888, 50530, 58172 anti-influenza_Chain 4679 12321, 19963, 27605, 35247, 42889, 50531, 58173 anti-influenza_Chain 4680 12322, 19964, 27606, 35248, 42890, 50532, 58174 anti-influenza_Chain 4681 12323, 19965, 27607, 35249, 42891, 50533, 58175 anti-influenza_Chain 4682 12324, 19966, 27608, 35250, 42892, 50534, 58176 anti-influenza_Chain 4683 12325, 19967, 27609, 35251, 42893, 50535, 58177 anti-influenza_Chain 4684 12326, 19968, 27610, 35252, 42894, 50536, 58178 anti-influenza_Chain 4685 12327, 19969, 27611, 35253, 42895, 50537, 58179 anti-influenza_Chain 4686 12328, 19970, 27612, 35254, 42896, 50538, 58180 anti-influenza_Chain 4687 12329, 19971, 27613, 35255, 42897, 50539, 58181 anti-influenza_Chain 4688 12330, 19972, 27614, 35256, 42898, 50540, 58182 anti-influenza_Chain 4689 12331, 19973, 27615, 35257, 42899, 50541, 58183 anti-influenza_Chain 4690 12332, 19974, 27616, 35258, 42900, 50542, 58184 anti-influenza_Chain 4691 12333, 19975, 27617, 35259, 42901, 50543, 58185 anti-influenza_Chain 4692 12334, 19976, 27618, 35260, 42902, 50544, 58186 anti-influenza_Chain 4693 12335, 19977, 27619, 35261, 42903, 50545, 58187 anti-influenza_Chain 4694 12336, 19978, 27620, 35262, 42904, 50546, 58188 anti-influenza_Chain 4695 12337, 19979, 27621, 35263, 42905, 50547, 58189 anti-influenza_Chain 4696 12338, 19980, 27622, 35264, 42906, 50548, 58190 anti-influenza_Chain 4697 12339, 19981, 27623, 35265, 42907, 50549, 58191 anti-influenza_Chain 4698 12340, 19982, 27624, 35266, 42908, 50550, 58192 anti-influenza_Chain 4699 12341, 19983, 27625, 35267, 42909, 50551, 58193 anti-influenza_Chain 4700 12342, 19984, 27626, 35268, 42910, 50552, 58194 anti-influenza_Chain 4701 12343, 19985, 27627, 35269, 42911, 50553, 58195 anti-influenza_Chain 4702 12344, 19986, 27628, 35270, 42912, 50554, 58196 anti-influenza_Chain 4703 12345, 19987, 27629, 35271, 42913, 50555, 58197 anti-influenza_Chain 4704 12346, 19988, 27630, 35272, 42914, 50556, 58198 anti-influenza_Chain 4705 12347, 19989, 27631, 35273, 42915, 50557, 58199 anti-influenza_Chain 4706 12348, 19990, 27632, 35274, 42916, 50558, 58200 anti-influenza_Chain 4707 12349, 19991, 27633, 35275, 42917, 50559, 58201 anti-influenza_Chain 4708 12350, 19992, 27634, 35276, 42918, 50560, 58202 anti-influenza_Chain 4709 12351, 19993, 27635, 35277, 42919, 50561, 58203 anti-influenza_Chain 4710 12352, 19994, 27636, 35278, 42920, 50562, 58204 anti-influenza_Chain 4711 12353, 19995, 27637, 35279, 42921, 50563, 58205 anti-influenza_Chain 4712 12354, 19996, 27638, 35280, 42922, 50564, 58206 anti-influenza_Chain 4713 12355, 19997, 27639, 35281, 42923, 50565, 58207 anti-influenza_Chain 4714 12356, 19998, 27640, 35282, 42924, 50566, 58208 anti-influenza_Chain 4715 12357, 19999, 27641, 35283, 42925, 50567, 58209 anti-influenza_Chain 4716 12358, 20000, 27642, 35284, 42926, 50568, 58210 anti-influenza_Chain 4717 12359, 20001, 27643, 35285, 42927, 50569, 58211 anti-influenza_Chain 4718 12360, 20002, 27644, 35286, 42928, 50570, 58212 anti-influenza_Chain 4719 12361, 20003, 27645, 35287, 42929, 50571, 58213 anti-influenza_Chain 4720 12362, 20004, 27646, 35288, 42930, 50572, 58214 anti-influenza_Chain 4721 12363, 20005, 27647, 35289, 42931, 50573, 58215 anti-influenza_Chain 4722 12364, 20006, 27648, 35290, 42932, 50574, 58216 anti-influenza_Chain 4723 12365, 20007, 27649, 35291, 42933, 50575, 58217 anti-influenza_Chain 4724 12366, 20008, 27650, 35292, 42934, 50576, 58218 anti-influenza_Chain 4725 12367, 20009, 27651, 35293, 42935, 50577, 58219 anti-influenza_Chain 4726 12368, 20010, 27652, 35294, 42936, 50578, 58220 anti-influenza_Chain 4727 12369, 20011, 27653, 35295, 42937, 50579, 58221 anti-influenza_Chain 4728 12370, 20012, 27654, 35296, 42938, 50580, 58222 anti-influenza_Chain 4729 12371, 20013, 27655, 35297, 42939, 50581, 58223 anti-influenza_Chain 4730 12372, 20014, 27656, 35298, 42940, 50582, 58224 anti-influenza_Chain 4731 12373, 20015, 27657, 35299, 42941, 50583, 58225 anti-influenza_Chain 4732 12374, 20016, 27658, 35300, 42942, 50584, 58226 anti-influenza_Chain 4733 12375, 20017, 27659, 35301, 42943, 50585, 58227 anti-influenza_Chain 4734 12376, 20018, 27660, 35302, 42944, 50586, 58228 anti-influenza_Chain 4735 12377, 20019, 27661, 35303, 42945, 50587, 58229 anti-influenza_Chain 4736 12378, 20020, 27662, 35304, 42946, 50588, 58230 anti-influenza_Chain 4737 12379, 20021, 27663, 35305, 42947, 50589, 58231 anti-influenza_Chain 4738 12380, 20022, 27664, 35306, 42948, 50590, 58232 anti-influenza_Chain 4739 12381, 20023, 27665, 35307, 42949, 50591, 58233 anti-influenza_Chain 4740 12382, 20024, 27666, 35308, 42950, 50592, 58234 anti-influenza_Chain 4741 12383, 20025, 27667, 35309, 42951, 50593, 58235 anti-influenza_Chain 4742 12384, 20026, 27668, 35310, 42952, 50594, 58236 anti-influenza_Chain 4743 12385, 20027, 27669, 35311, 42953, 50595, 58237 anti-influenza_Chain 4744 12386, 20028, 27670, 35312, 42954, 50596, 58238 anti-influenza_Chain 4745 12387, 20029, 27671, 35313, 42955, 50597, 58239 anti-influenza_Chain 4746 12388, 20030, 27672, 35314, 42956, 50598, 58240 anti-influenza_Chain 4747 12389, 20031, 27673, 35315, 42957, 50599, 58241 anti-influenza_Chain 4748 12390, 20032, 27674, 35316, 42958, 50600, 58242 anti-influenza_Chain 4749 12391, 20033, 27675, 35317, 42959, 50601, 58243 anti-influenza_Chain 4750 12392, 20034, 27676, 35318, 42960, 50602, 58244 anti-influenza_Chain 4751 12393, 20035, 27677, 35319, 42961, 50603, 58245 anti-influenza_Chain 4752 12394, 20036, 27678, 35320, 42962, 50604, 58246 anti-influenza_Chain 4753 12395, 20037, 27679, 35321, 42963, 50605, 58247 anti-influenza_Chain 4754 12396, 20038, 27680, 35322, 42964, 50606, 58248 anti-influenza_Chain 4755 12397, 20039, 27681, 35323, 42965, 50607, 58249 anti-influenza_Chain 4756 12398, 20040, 27682, 35324, 42966, 50608, 58250 anti-influenza_Chain 4757 12399, 20041, 27683, 35325, 42967, 50609, 58251 anti-influenza_Chain 4758 12400, 20042, 27684, 35326, 42968, 50610, 58252 anti-influenza_Chain 4759 12401, 20043, 27685, 35327, 42969, 50611, 58253 anti-influenza_Chain 4760 12402, 20044, 27686, 35328, 42970, 50612, 58254 anti-influenza_Chain 4761 12403, 20045, 27687, 35329, 42971, 50613, 58255 anti-influenza_Chain 4762 12404, 20046, 27688, 35330, 42972, 50614, 58256 anti-influenza_Chain 4763 12405, 20047, 27689, 35331, 42973, 50615, 58257 anti-influenza_Chain 4764 12406, 20048, 27690, 35332, 42974, 50616, 58258 anti-influenza_Chain 4765 12407, 20049, 27691, 35333, 42975, 50617, 58259 anti-influenza_Chain 4766 12408, 20050, 27692, 35334, 42976, 50618, 58260 anti-influenza_Chain 4767 12409, 20051, 27693, 35335, 42977, 50619, 58261 anti-influenza_Chain 4768 12410, 20052, 27694, 35336, 42978, 50620, 58262 anti-influenza_Chain 4769 12411, 20053, 27695, 35337, 42979, 50621, 58263 anti-influenza_Chain 4770 12412, 20054, 27696, 35338, 42980, 50622, 58264 anti-influenza_Chain 4771 12413, 20055, 27697, 35339, 42981, 50623, 58265 anti-influenza_Chain 4772 12414, 20056, 27698, 35340, 42982, 50624, 58266 anti-influenza_Chain 4773 12415, 20057, 27699, 35341, 42983, 50625, 58267 anti-influenza_Chain 4774 12416, 20058, 27700, 35342, 42984, 50626, 58268 anti-influenza_Chain 4775 12417, 20059, 27701, 35343, 42985, 50627, 58269 anti-influenza_Chain 4776 12418, 20060, 27702, 35344, 42986, 50628, 58270 anti-influenza_Chain 4777 12419, 20061, 27703, 35345, 42987, 50629, 58271 anti-influenza_Chain 4778 12420, 20062, 27704, 35346, 42988, 50630, 58272 anti-influenza_Chain 4779 12421, 20063, 27705, 35347, 42989, 50631, 58273 anti-influenza_Chain 4780 12422, 20064, 27706, 35348, 42990, 50632, 58274 anti-influenza_Chain 4781 12423, 20065, 27707, 35349, 42991, 50633, 58275 anti-influenza_Chain 4782 12424, 20066, 27708, 35350, 42992, 50634, 58276 anti-influenza_Chain 4783 12425, 20067, 27709, 35351, 42993, 50635, 58277 anti-influenza_Chain 4784 12426, 20068, 27710, 35352, 42994, 50636, 58278 anti-influenza_Chain 4785 12427, 20069, 27711, 35353, 42995, 50637, 58279 anti-influenza_Chain 4786 12428, 20070, 27712, 35354, 42996, 50638, 58280 anti-influenza_Chain 4787 12429, 20071, 27713, 35355, 42997, 50639, 58281 anti-influenza_Chain 4788 12430, 20072, 27714, 35356, 42998, 50640, 58282 anti-influenza_Chain 4789 12431, 20073, 27715, 35357, 42999, 50641, 58283 anti-influenza_Chain 4790 12432, 20074, 27716, 35358, 43000, 50642, 58284 anti-influenza_Chain 4791 12433, 20075, 27717, 35359, 43001, 50643, 58285 anti-influenza_Chain 4792 12434, 20076, 27718, 35360, 43002, 50644, 58286 anti-influenza_Chain 4793 12435, 20077, 27719, 35361, 43003, 50645, 58287 anti-influenza_Chain 4794 12436, 20078, 27720, 35362, 43004, 50646, 58288 anti-influenza_Chain 4795 12437, 20079, 27721, 35363, 43005, 50647, 58289 anti-influenza_Chain 4796 12438, 20080, 27722, 35364, 43006, 50648, 58290 anti-influenza_Chain 4797 12439, 20081, 27723, 35365, 43007, 50649, 58291 anti-influenza_Chain 4798 12440, 20082, 27724, 35366, 43008, 50650, 58292 anti-influenza_Chain 4799 12441, 20083, 27725, 35367, 43009, 50651, 58293 anti-influenza_Chain 4800 12442, 20084, 27726, 35368, 43010, 50652, 58294 anti-influenza_Chain 4801 12443, 20085, 27727, 35369, 43011, 50653, 58295 anti-influenza_Chain 4802 12444, 20086, 27728, 35370, 43012, 50654, 58296 anti-influenza_Chain 4803 12445, 20087, 27729, 35371, 43013, 50655, 58297 anti-influenza_Chain 4804 12446, 20088, 27730, 35372, 43014, 50656, 58298 anti-influenza_Chain 4805 12447, 20089, 27731, 35373, 43015, 50657, 58299 anti-influenza_Chain 4806 12448, 20090, 27732, 35374, 43016, 50658, 58300 anti-influenza_Chain 4807 12449, 20091, 27733, 35375, 43017, 50659, 58301 anti-influenza_Chain 4808 12450, 20092, 27734, 35376, 43018, 50660, 58302 anti-influenza_Chain 4809 12451, 20093, 27735, 35377, 43019, 50661, 58303 anti-influenza_Chain 4810 12452, 20094, 27736, 35378, 43020, 50662, 58304 anti-influenza_Chain 4811 12453, 20095, 27737, 35379, 43021, 50663, 58305 anti-influenza_Chain 4812 12454, 20096, 27738, 35380, 43022, 50664, 58306 anti-influenza_Chain 4813 12455, 20097, 27739, 35381, 43023, 50665, 58307 anti-influenza_Chain 4814 12456, 20098, 27740, 35382, 43024, 50666, 58308 anti-influenza_Chain 4815 12457, 20099, 27741, 35383, 43025, 50667, 58309 anti-influenza_Chain 4816 12458, 20100, 27742, 35384, 43026, 50668, 58310 anti-influenza_Chain 4817 12459, 20101, 27743, 35385, 43027, 50669, 58311 anti-influenza_Chain 4818 12460, 20102, 27744, 35386, 43028, 50670, 58312 anti-influenza_Chain 4819 12461, 20103, 27745, 35387, 43029, 50671, 58313 anti-influenza_Chain 4820 12462, 20104, 27746, 35388, 43030, 50672, 58314 anti-influenza_Chain 4821 12463, 20105, 27747, 35389, 43031, 50673, 58315 anti-influenza_Chain 4822 12464, 20106, 27748, 35390, 43032, 50674, 58316 anti-influenza_Chain 4823 12465, 20107, 27749, 35391, 43033, 50675, 58317 anti-influenza_Chain 4824 12466, 20108, 27750, 35392, 43034, 50676, 58318 anti-influenza_Chain 4825 12467, 20109, 27751, 35393, 43035, 50677, 58319 anti-influenza_Chain 4826 12468, 20110, 27752, 35394, 43036, 50678, 58320 anti-influenza_Chain 4827 12469, 20111, 27753, 35395, 43037, 50679, 58321 anti-influenza_Chain 4828 12470, 20112, 27754, 35396, 43038, 50680, 58322 anti-influenza_Chain 4829 12471, 20113, 27755, 35397, 43039, 50681, 58323 anti-influenza_Chain 4830 12472, 20114, 27756, 35398, 43040, 50682, 58324 anti-influenza_Chain 4831 12473, 20115, 27757, 35399, 43041, 50683, 58325 anti-influenza_Chain 4832 12474, 20116, 27758, 35400, 43042, 50684, 58326 anti-influenza_Chain 4833 12475, 20117, 27759, 35401, 43043, 50685, 58327 anti-influenza_Chain 4834 12476, 20118, 27760, 35402, 43044, 50686, 58328 anti-influenza_Chain 4835 12477, 20119, 27761, 35403, 43045, 50687, 58329 anti-influenza_Chain 4836 12478, 20120, 27762, 35404, 43046, 50688, 58330 anti-influenza_Chain 4837 12479, 20121, 27763, 35405, 43047, 50689, 58331 anti-influenza_Chain 4838 12480, 20122, 27764, 35406, 43048, 50690, 58332 anti-influenza_Chain 4839 12481, 20123, 27765, 35407, 43049, 50691, 58333 anti-influenza_Chain 4840 12482, 20124, 27766, 35408, 43050, 50692, 58334 anti-influenza_Chain 4841 12483, 20125, 27767, 35409, 43051, 50693, 58335 anti-influenza_Chain 4842 12484, 20126, 27768, 35410, 43052, 50694, 58336 anti-influenza_Chain 4843 12485, 20127, 27769, 35411, 43053, 50695, 58337 anti-influenza_Chain 4844 12486, 20128, 27770, 35412, 43054, 50696, 58338 anti-influenza_Chain 4845 12487, 20129, 27771, 35413, 43055, 50697, 58339 anti-influenza_Chain 4846 12488, 20130, 27772, 35414, 43056, 50698, 58340 anti-influenza_Chain 4847 12489, 20131, 27773, 35415, 43057, 50699, 58341 anti-influenza_Chain 4848 12490, 20132, 27774, 35416, 43058, 50700, 58342 anti-influenza_Chain 4849 12491, 20133, 27775, 35417, 43059, 50701, 58343 anti-influenza_Chain 4850 12492, 20134, 27776, 35418, 43060, 50702, 58344 anti-influenza_Chain 4851 12493, 20135, 27777, 35419, 43061, 50703, 58345 anti-influenza_Chain 4852 12494, 20136, 27778, 35420, 43062, 50704, 58346 anti-influenza_Chain 4853 12495, 20137, 27779, 35421, 43063, 50705, 58347 anti-influenza_Chain 4854 12496, 20138, 27780, 35422, 43064, 50706, 58348 anti-influenza_Chain 4855 12497, 20139, 27781, 35423, 43065, 50707, 58349 anti-influenza_Chain 4856 12498, 20140, 27782, 35424, 43066, 50708, 58350 anti-influenza_Chain 4857 12499, 20141, 27783, 35425, 43067, 50709, 58351 anti-influenza_Chain 4858 12500, 20142, 27784, 35426, 43068, 50710, 58352 anti-influenza_Chain 4859 12501, 20143, 27785, 35427, 43069, 50711, 58353 anti-influenza_Chain 4860 12502, 20144, 27786, 35428, 43070, 50712, 58354 anti-influenza_Chain 4861 12503, 20145, 27787, 35429, 43071, 50713, 58355 anti-influenza_Chain 4862 12504, 20146, 27788, 35430, 43072, 50714, 58356 anti-influenza_Chain 4863 12505, 20147, 27789, 35431, 43073, 50715, 58357 anti-influenza_Chain 4864 12506, 20148, 27790, 35432, 43074, 50716, 58358 anti-influenza_Chain 4865 12507, 20149, 27791, 35433, 43075, 50717, 58359 anti-influenza_Chain 4866 12508, 20150, 27792, 35434, 43076, 50718, 58360 anti-influenza_Chain 4867 12509, 20151, 27793, 35435, 43077, 50719, 58361 anti-influenza_Chain 4868 12510, 20152, 27794, 35436, 43078, 50720, 58362 anti-influenza_Chain 4869 12511, 20153, 27795, 35437, 43079, 50721, 58363 anti-influenza_Chain 4870 12512, 20154, 27796, 35438, 43080, 50722, 58364 anti-influenza_Chain 4871 12513, 20155, 27797, 35439, 43081, 50723, 58365 anti-influenza_Chain 4872 12514, 20156, 27798, 35440, 43082, 50724, 58366 anti-influenza_Chain 4873 12515, 20157, 27799, 35441, 43083, 50725, 58367 anti-influenza_Chain 4874 12516, 20158, 27800, 35442, 43084, 50726, 58368 anti-influenza_Chain 4875 12517, 20159, 27801, 35443, 43085, 50727, 58369 anti-influenza_Chain 4876 12518, 20160, 27802, 35444, 43086, 50728, 58370 anti-influenza_Chain 4877 12519, 20161, 27803, 35445, 43087, 50729, 58371 anti-influenza_Chain 4878 12520, 20162, 27804, 35446, 43088, 50730, 58372 anti-influenza_Chain 4879 12521, 20163, 27805, 35447, 43089, 50731, 58373 anti-influenza_Chain 4880 12522, 20164, 27806, 35448, 43090, 50732, 58374 anti-influenza_Chain 4881 12523, 20165, 27807, 35449, 43091, 50733, 58375 anti-influenza_Chain 4882 12524, 20166, 27808, 35450, 43092, 50734, 58376 anti-influenza_Chain 4883 12525, 20167, 27809, 35451, 43093, 50735, 58377 anti-influenza_Chain 4884 12526, 20168, 27810, 35452, 43094, 50736, 58378 anti-influenza_Chain 4885 12527, 20169, 27811, 35453, 43095, 50737, 58379 anti-influenza_Chain 4886 12528, 20170, 27812, 35454, 43096, 50738, 58380 anti-influenza_Chain 4887 12529, 20171, 27813, 35455, 43097, 50739, 58381 anti-influenza_Chain 4888 12530, 20172, 27814, 35456, 43098, 50740, 58382 anti-influenza_Chain 4889 12531, 20173, 27815, 35457, 43099, 50741, 58383 anti-influenza_Chain 4890 12532, 20174, 27816, 35458, 43100, 50742, 58384 anti-influenza_Chain 4891 12533, 20175, 27817, 35459, 43101, 50743, 58385 anti-influenza_Chain 4892 12534, 20176, 27818, 35460, 43102, 50744, 58386 anti-influenza_Chain 4893 12535, 20177, 27819, 35461, 43103, 50745, 58387 anti-influenza_Chain 4894 12536, 20178, 27820, 35462, 43104, 50746, 58388 anti-influenza_Chain 4895 12537, 20179, 27821, 35463, 43105, 50747, 58389 anti-influenza_Chain 4896 12538, 20180, 27822, 35464, 43106, 50748, 58390 anti-influenza_Chain 4897 12539, 20181, 27823, 35465, 43107, 50749, 58391 anti-influenza_Chain 4898 12540, 20182, 27824, 35466, 43108, 50750, 58392 anti-influenza_Chain 4899 12541, 20183, 27825, 35467, 43109, 50751, 58393 anti-influenza_Chain 4900 12542, 20184, 27826, 35468, 43110, 50752, 58394 anti-influenza_Chain 4901 12543, 20185, 27827, 35469, 43111, 50753, 58395 anti-influenza_Chain 4902 12544, 20186, 27828, 35470, 43112, 50754, 58396 anti-influenza_Chain 4903 12545, 20187, 27829, 35471, 43113, 50755, 58397 anti-influenza_Chain 4904 12546, 20188, 27830, 35472, 43114, 50756, 58398 anti-influenza_Chain 4905 12547, 20189, 27831, 35473, 43115, 50757, 58399 anti-influenza_Chain 4906 12548, 20190, 27832, 35474, 43116, 50758, 58400 anti-influenza_Chain 4907 12549, 20191, 27833, 35475, 43117, 50759, 58401 anti-influenza_Chain 4908 12550, 20192, 27834, 35476, 43118, 50760, 58402 anti-influenza_Chain 4909 12551, 20193, 27835, 35477, 43119, 50761, 58403 anti-influenza_Chain 4910 12552, 20194, 27836, 35478, 43120, 50762, 58404 anti-influenza_Chain 4911 12553, 20195, 27837, 35479, 43121, 50763, 58405 anti-influenza_Chain 4912 12554, 20196, 27838, 35480, 43122, 50764, 58406 anti-influenza_Chain 4913 12555, 20197, 27839, 35481, 43123, 50765, 58407 anti-influenza_Chain 4914 12556, 20198, 27840, 35482, 43124, 50766, 58408 anti-influenza_Chain 4915 12557, 20199, 27841, 35483, 43125, 50767, 58409 anti-influenza_Chain 4916 12558, 20200, 27842, 35484, 43126, 50768, 58410 anti-influenza_Chain 4917 12559, 20201, 27843, 35485, 43127, 50769, 58411 anti-influenza_Chain 4918 12560, 20202, 27844, 35486, 43128, 50770, 58412 anti-influenza_Chain 4919 12561, 20203, 27845, 35487, 43129, 50771, 58413 anti-influenza_Chain 4920 12562, 20204, 27846, 35488, 43130, 50772, 58414 anti-influenza_Chain 4921 12563, 20205, 27847, 35489, 43131, 50773, 58415 anti-influenza_Chain 4922 12564, 20206, 27848, 35490, 43132, 50774, 58416 anti-influenza_Chain 4923 12565, 20207, 27849, 35491, 43133, 50775, 58417 anti-influenza_Chain 4924 12566, 20208, 27850, 35492, 43134, 50776, 58418 anti-influenza_Chain 4925 12567, 20209, 27851, 35493, 43135, 50777, 58419 anti-influenza_Chain 4926 12568, 20210, 27852, 35494, 43136, 50778, 58420 anti-influenza_Chain 4927 12569, 20211, 27853, 35495, 43137, 50779, 58421 anti-influenza_Chain 4928 12570, 20212, 27854, 35496, 43138, 50780, 58422 anti-influenza_Chain 4929 12571, 20213, 27855, 35497, 43139, 50781, 58423 anti-influenza_Chain 4930 12572, 20214, 27856, 35498, 43140, 50782, 58424 anti-influenza_Chain 4931 12573, 20215, 27857, 35499, 43141, 50783, 58425 anti-influenza_Chain 4932 12574, 20216, 27858, 35500, 43142, 50784, 58426 anti-influenza_Chain 4933 12575, 20217, 27859, 35501, 43143, 50785, 58427 anti-influenza_Chain 4934 12576, 20218, 27860, 35502, 43144, 50786, 58428 anti-influenza_Chain 4935 12577, 20219, 27861, 35503, 43145, 50787, 58429 anti-influenza_Chain 4936 12578, 20220, 27862, 35504, 43146, 50788, 58430 anti-influenza_Chain 4937 12579, 20221, 27863, 35505, 43147, 50789, 58431 anti-influenza_Chain 4938 12580, 20222, 27864, 35506, 43148, 50790, 58432 anti-influenza_Chain 4939 12581, 20223, 27865, 35507, 43149, 50791, 58433 anti-influenza_Chain 4940 12582, 20224, 27866, 35508, 43150, 50792, 58434 anti-influenza_Chain 4941 12583, 20225, 27867, 35509, 43151, 50793, 58435 anti-influenza_Chain 4942 12584, 20226, 27868, 35510, 43152, 50794, 58436 anti-influenza_Chain 4943 12585, 20227, 27869, 35511, 43153, 50795, 58437 anti-influenza_Chain 4944 12586, 20228, 27870, 35512, 43154, 50796, 58438 anti-influenza_Chain 4945 12587, 20229, 27871, 35513, 43155, 50797, 58439 anti-influenza_Chain 4946 12588, 20230, 27872, 35514, 43156, 50798, 58440 anti-influenza_Chain 4947 12589, 20231, 27873, 35515, 43157, 50799, 58441 anti-influenza_Chain 4948 12590, 20232, 27874, 35516, 43158, 50800, 58442 anti-influenza_Chain 4949 12591, 20233, 27875, 35517, 43159, 50801, 58443 anti-influenza_Chain 4950 12592, 20234, 27876, 35518, 43160, 50802, 58444 anti-influenza_Chain 4951 12593, 20235, 27877, 35519, 43161, 50803, 58445 anti-influenza_Chain 4952 12594, 20236, 27878, 35520, 43162, 50804, 58446 anti-influenza_Chain 4953 12595, 20237, 27879, 35521, 43163, 50805, 58447 anti-influenza_Chain 4954 12596, 20238, 27880, 35522, 43164, 50806, 58448 anti-influenza_Chain 4955 12597, 20239, 27881, 35523, 43165, 50807, 58449 anti-influenza_Chain 4956 12598, 20240, 27882, 35524, 43166, 50808, 58450 anti-influenza_Chain 4957 12599, 20241, 27883, 35525, 43167, 50809, 58451 anti-influenza_Chain 4958 12600, 20242, 27884, 35526, 43168, 50810, 58452 anti-influenza_Chain 4959 12601, 20243, 27885, 35527, 43169, 50811, 58453 anti-influenza_Chain 4960 12602, 20244, 27886, 35528, 43170, 50812, 58454 anti-influenza_Chain 4961 12603, 20245, 27887, 35529, 43171, 50813, 58455 anti-influenza_Chain 4962 12604, 20246, 27888, 35530, 43172, 50814, 58456 anti-influenza_Chain 4963 12605, 20247, 27889, 35531, 43173, 50815, 58457 anti-influenza_Chain 4964 12606, 20248, 27890, 35532, 43174, 50816, 58458 anti-influenza_Chain 4965 12607, 20249, 27891, 35533, 43175, 50817, 58459 anti-influenza_Chain 4966 12608, 20250, 27892, 35534, 43176, 50818, 58460 anti-influenza_Chain 4967 12609, 20251, 27893, 35535, 43177, 50819, 58461 anti-influenza_Chain 4968 12610, 20252, 27894, 35536, 43178, 50820, 58462 anti-influenza_Chain 4969 12611, 20253, 27895, 35537, 43179, 50821, 58463 anti-influenza_Chain 4970 12612, 20254, 27896, 35538, 43180, 50822, 58464 anti-influenza_Chain 4971 12613, 20255, 27897, 35539, 43181, 50823, 58465 anti-influenza_Chain 4972 12614, 20256, 27898, 35540, 43182, 50824, 58466 anti-influenza_Chain 4973 12615, 20257, 27899, 35541, 43183, 50825, 58467 anti-influenza_Chain 4974 12616, 20258, 27900, 35542, 43184, 50826, 58468 anti-influenza_Chain 4975 12617, 20259, 27901, 35543, 43185, 50827, 58469 anti-influenza_Chain 4976 12618, 20260, 27902, 35544, 43186, 50828, 58470 anti-influenza_Chain 4977 12619, 20261, 27903, 35545, 43187, 50829, 58471 anti-influenza_Chain 4978 12620, 20262, 27904, 35546, 43188, 50830, 58472 anti-influenza_Chain 4979 12621, 20263, 27905, 35547, 43189, 50831, 58473 anti-influenza_Chain 4980 12622, 20264, 27906, 35548, 43190, 50832, 58474 anti-influenza_Chain 4981 12623, 20265, 27907, 35549, 43191, 50833, 58475 anti-influenza_Chain 4982 12624, 20266, 27908, 35550, 43192, 50834, 58476 anti-influenza_Chain 4983 12625, 20267, 27909, 35551, 43193, 50835, 58477 anti-influenza_Chain 4984 12626, 20268, 27910, 35552, 43194, 50836, 58478 anti-influenza_Chain 4985 12627, 20269, 27911, 35553, 43195, 50837, 58479 anti-influenza_Chain 4986 12628, 20270, 27912, 35554, 43196, 50838, 58480 anti-influenza_Chain 4987 12629, 20271, 27913, 35555, 43197, 50839, 58481 anti-influenza_Chain 4988 12630, 20272, 27914, 35556, 43198, 50840, 58482 anti-influenza_Chain 4989 12631, 20273, 27915, 35557, 43199, 50841, 58483 anti-influenza_Chain 4990 12632, 20274, 27916, 35558, 43200, 50842, 58484 anti-influenza_Chain 4991 12633, 20275, 27917, 35559, 43201, 50843, 58485 anti-influenza_Chain 4992 12634, 20276, 27918, 35560, 43202, 50844, 58486 anti-influenza_Chain 4993 12635, 20277, 27919, 35561, 43203, 50845, 58487 anti-influenza_Chain 4994 12636, 20278, 27920, 35562, 43204, 50846, 58488 anti-influenza_Chain 4995 12637, 20279, 27921, 35563, 43205, 50847, 58489 anti-influenza_Chain 4996 12638, 20280, 27922, 35564, 43206, 50848, 58490 anti-influenza_Chain 4997 12639, 20281, 27923, 35565, 43207, 50849, 58491 anti-influenza_Chain 4998 12640, 20282, 27924, 35566, 43208, 50850, 58492 anti-influenza_Chain 4999 12641, 20283, 27925, 35567, 43209, 50851, 58493 anti-influenza_Chain 5000 12642, 20284, 27926, 35568, 43210, 50852, 58494 anti-influenza_Chain 5001 12643, 20285, 27927, 35569, 43211, 50853, 58495 anti-influenza_Chain 5002 12644, 20286, 27928, 35570, 43212, 50854, 58496 anti-influenza_Chain 5003 12645, 20287, 27929, 35571, 43213, 50855, 58497 anti-influenza_Chain 5004 12646, 20288, 27930, 35572, 43214, 50856, 58498 anti-influenza_Chain 5005 12647, 20289, 27931, 35573, 43215, 50857, 58499 anti-influenza_Chain 5006 12648, 20290, 27932, 35574, 43216, 50858, 58500 anti-influenza_Chain 5007 12649, 20291, 27933, 35575, 43217, 50859, 58501 anti-influenza_Chain 5008 12650, 20292, 27934, 35576, 43218, 50860, 58502 anti-influenza_Chain 5009 12651, 20293, 27935, 35577, 43219, 50861, 58503 anti-influenza_Chain 5010 12652, 20294, 27936, 35578, 43220, 50862, 58504 anti-influenza_Chain 5011 12653, 20295, 27937, 35579, 43221, 50863, 58505 anti-influenza_Chain 5012 12654, 20296, 27938, 35580, 43222, 50864, 58506 anti-influenza_Chain 5013 12655, 20297, 27939, 35581, 43223, 50865, 58507 anti-influenza_Chain 5014 12656, 20298, 27940, 35582, 43224, 50866, 58508 anti-influenza_Chain 5015 12657, 20299, 27941, 35583, 43225, 50867, 58509 anti-influenza_Chain 5016 12658, 20300, 27942, 35584, 43226, 50868, 58510 anti-influenza_Chain 5017 12659, 20301, 27943, 35585, 43227, 50869, 58511 anti-influenza_Chain 5018 12660, 20302, 27944, 35586, 43228, 50870, 58512 anti-influenza_Chain 5019 12661, 20303, 27945, 35587, 43229, 50871, 58513 anti-influenza_Chain 5020 12662, 20304, 27946, 35588, 43230, 50872, 58514 anti-influenza_Chain 5021 12663, 20305, 27947, 35589, 43231, 50873, 58515 anti-influenza_Chain 5022 12664, 20306, 27948, 35590, 43232, 50874, 58516 anti-influenza_Chain 5023 12665, 20307, 27949, 35591, 43233, 50875, 58517 anti-influenza_Chain 5024 12666, 20308, 27950, 35592, 43234, 50876, 58518 anti-influenza_Chain 5025 12667, 20309, 27951, 35593, 43235, 50877, 58519 anti-influenza_Chain 5026 12668, 20310, 27952, 35594, 43236, 50878, 58520 anti-influenza_Chain 5027 12669, 20311, 27953, 35595, 43237, 50879, 58521 anti-influenza_Chain 5028 12670, 20312, 27954, 35596, 43238, 50880, 58522 anti-influenza_Chain 5029 12671, 20313, 27955, 35597, 43239, 50881, 58523 anti-influenza_Chain 5030 12672, 20314, 27956, 35598, 43240, 50882, 58524 anti-influenza_Chain 5031 12673, 20315, 27957, 35599, 43241, 50883, 58525 anti-influenza_Chain 5032 12674, 20316, 27958, 35600, 43242, 50884, 58526 anti-influenza_Chain 5033 12675, 20317, 27959, 35601, 43243, 50885, 58527 anti-influenza_Chain 5034 12676, 20318, 27960, 35602, 43244, 50886, 58528 anti-influenza_Chain 5035 12677, 20319, 27961, 35603, 43245, 50887, 58529 anti-influenza_Chain 5036 12678, 20320, 27962, 35604, 43246, 50888, 58530 anti-influenza_Chain 5037 12679, 20321, 27963, 35605, 43247, 50889, 58531 anti-influenza_Chain 5038 12680, 20322, 27964, 35606, 43248, 50890, 58532 anti-influenza_Chain 5039 12681, 20323, 27965, 35607, 43249, 50891, 58533 anti-influenza_Chain 5040 12682, 20324, 27966, 35608, 43250, 50892, 58534 anti-influenza_Chain 5041 12683, 20325, 27967, 35609, 43251, 50893, 58535 anti-influenza_Chain 5042 12684, 20326, 27968, 35610, 43252, 50894, 58536 anti-influenza_Chain 5043 12685, 20327, 27969, 35611, 43253, 50895, 58537 anti-influenza_Chain 5044 12686, 20328, 27970, 35612, 43254, 50896, 58538 anti-influenza_Chain 5045 12687, 20329, 27971, 35613, 43255, 50897, 58539 anti-influenza_Chain 5046 12688, 20330, 27972, 35614, 43256, 50898, 58540 anti-influenza_Chain 5047 12689, 20331, 27973, 35615, 43257, 50899, 58541 anti-influenza_Chain 5048 12690, 20332, 27974, 35616, 43258, 50900, 58542 anti-influenza_Chain 5049 12691, 20333, 27975, 35617, 43259, 50901, 58543 anti-influenza_Chain 5050 12692, 20334, 27976, 35618, 43260, 50902, 58544 anti-influenza_Chain 5051 12693, 20335, 27977, 35619, 43261, 50903, 58545 anti-influenza_Chain 5052 12694, 20336, 27978, 35620, 43262, 50904, 58546 anti-influenza_Chain 5053 12695, 20337, 27979, 35621, 43263, 50905, 58547 anti-influenza_Chain 5054 12696, 20338, 27980, 35622, 43264, 50906, 58548 anti-influenza_Chain 5055 12697, 20339, 27981, 35623, 43265, 50907, 58549 anti-influenza_Chain 5056 12698, 20340, 27982, 35624, 43266, 50908, 58550 anti-influenza_Chain 5057 12699, 20341, 27983, 35625, 43267, 50909, 58551 anti-influenza_Chain 5058 12700, 20342, 27984, 35626, 43268, 50910, 58552 anti-influenza_Chain 5059 12701, 20343, 27985, 35627, 43269, 50911, 58553 anti-influenza_Chain 5060 12702, 20344, 27986, 35628, 43270, 50912, 58554 anti-influenza_Chain 5061 12703, 20345, 27987, 35629, 43271, 50913, 58555 anti-influenza_Chain 5062 12704, 20346, 27988, 35630, 43272, 50914, 58556 anti-influenza_Chain 5063 12705, 20347, 27989, 35631, 43273, 50915, 58557 anti-influenza_Chain 5064 12706, 20348, 27990, 35632, 43274, 50916, 58558 anti-influenza_Chain 5065 12707, 20349, 27991, 35633, 43275, 50917, 58559 anti-influenza_Chain 5066 12708, 20350, 27992, 35634, 43276, 50918, 58560 anti-influenza_Chain 5067 12709, 20351, 27993, 35635, 43277, 50919, 58561 anti-influenza_Chain 5068 12710, 20352, 27994, 35636, 43278, 50920, 58562 anti-influenza_Chain 5069 12711, 20353, 27995, 35637, 43279, 50921, 58563 anti-influenza_Chain 5070 12712, 20354, 27996, 35638, 43280, 50922, 58564 anti-influenza_Chain 5071 12713, 20355, 27997, 35639, 43281, 50923, 58565 anti-influenza_Chain 5072 12714, 20356, 27998, 35640, 43282, 50924, 58566 anti-influenza_Chain 5073 12715, 20357, 27999, 35641, 43283, 50925, 58567 anti-influenza_Chain 5074 12716, 20358, 28000, 35642, 43284, 50926, 58568 anti-influenza_Chain 5075 12717, 20359, 28001, 35643, 43285, 50927, 58569 anti-influenza_Chain 5076 12718, 20360, 28002, 35644, 43286, 50928, 58570 anti-influenza_Chain 5077 12719, 20361, 28003, 35645, 43287, 50929, 58571 anti-influenza_Chain 5078 12720, 20362, 28004, 35646, 43288, 50930, 58572 anti-influenza_Chain 5079 12721, 20363, 28005, 35647, 43289, 50931, 58573 anti-influenza_Chain 5080 12722, 20364, 28006, 35648, 43290, 50932, 58574 anti-influenza_Chain 5081 12723, 20365, 28007, 35649, 43291, 50933, 58575 anti-influenza_Chain 5082 12724, 20366, 28008, 35650, 43292, 50934, 58576 anti-influenza_Chain 5083 12725, 20367, 28009, 35651, 43293, 50935, 58577 anti-influenza_Chain 5084 12726, 20368, 28010, 35652, 43294, 50936, 58578 anti-influenza_Chain 5085 12727, 20369, 28011, 35653, 43295, 50937, 58579 anti-influenza_Chain 5086 12728, 20370, 28012, 35654, 43296, 50938, 58580 anti-influenza_Chain 5087 12729, 20371, 28013, 35655, 43297, 50939, 58581 anti-influenza_Chain 5088 12730, 20372, 28014, 35656, 43298, 50940, 58582 anti-influenza_Chain 5089 12731, 20373, 28015, 35657, 43299, 50941, 58583 anti-influenza_Chain 5090 12732, 20374, 28016, 35658, 43300, 50942, 58584 anti-influenza_Chain 5091 12733, 20375, 28017, 35659, 43301, 50943, 58585 anti-influenza_Chain 5092 12734, 20376, 28018, 35660, 43302, 50944, 58586 anti-influenza_Chain 5093 12735, 20377, 28019, 35661, 43303, 50945, 58587 anti-influenza_Chain 5094 12736, 20378, 28020, 35662, 43304, 50946, 58588 anti-influenza_Chain 5095 12737, 20379, 28021, 35663, 43305, 50947, 58589 anti-influenza_Chain 5096 12738, 20380, 28022, 35664, 43306, 50948, 58590 anti-influenza_Chain 5097 12739, 20381, 28023, 35665, 43307, 50949, 58591 anti-influenza_Chain 5098 12740, 20382, 28024, 35666, 43308, 50950, 58592 anti-influenza_Chain 5099 12741, 20383, 28025, 35667, 43309, 50951, 58593 anti-influenza_Chain 5100 12742, 20384, 28026, 35668, 43310, 50952, 58594 anti-influenza_Chain 5101 12743, 20385, 28027, 35669, 43311, 50953, 58595 anti-influenza_Chain 5102 12744, 20386, 28028, 35670, 43312, 50954, 58596 anti-influenza_Chain 5103 12745, 20387, 28029, 35671, 43313, 50955, 58597 anti-influenza_Chain 5104 12746, 20388, 28030, 35672, 43314, 50956, 58598 anti-influenza_Chain 5105 12747, 20389, 28031, 35673, 43315, 50957, 58599 anti-influenza_Chain 5106 12748, 20390, 28032, 35674, 43316, 50958, 58600 anti-influenza_Chain 5107 12749, 20391, 28033, 35675, 43317, 50959, 58601 anti-influenza_Chain 5108 12750, 20392, 28034, 35676, 43318, 50960, 58602 anti-influenza_Chain 5109 12751, 20393, 28035, 35677, 43319, 50961, 58603 anti-influenza_Chain 5110 12752, 20394, 28036, 35678, 43320, 50962, 58604 anti-influenza_Chain 5111 12753, 20395, 28037, 35679, 43321, 50963, 58605 anti-influenza_Chain 5112 12754, 20396, 28038, 35680, 43322, 50964, 58606 anti-influenza_Chain 5113 12755, 20397, 28039, 35681, 43323, 50965, 58607 anti-influenza_Chain 5114 12756, 20398, 28040, 35682, 43324, 50966, 58608 anti-influenza_Chain 5115 12757, 20399, 28041, 35683, 43325, 50967, 58609 anti-influenza_Chain 5116 12758, 20400, 28042, 35684, 43326, 50968, 58610 anti-influenza_Chain 5117 12759, 20401, 28043, 35685, 43327, 50969, 58611 anti-influenza_Chain 5118 12760, 20402, 28044, 35686, 43328, 50970, 58612 anti-influenza_Chain 5119 12761, 20403, 28045, 35687, 43329, 50971, 58613 anti-influenza_Chain 5120 12762, 20404, 28046, 35688, 43330, 50972, 58614 anti-influenza_Chain 5121 12763, 20405, 28047, 35689, 43331, 50973, 58615 anti-influenza_Chain 5122 12764, 20406, 28048, 35690, 43332, 50974, 58616 anti-influenza_Chain 5123 12765, 20407, 28049, 35691, 43333, 50975, 58617 anti-influenza_Chain 5124 12766, 20408, 28050, 35692, 43334, 50976, 58618 anti-influenza_Chain 5125 12767, 20409, 28051, 35693, 43335, 50977, 58619 anti-influenza_Chain 5126 12768, 20410, 28052, 35694, 43336, 50978, 58620 anti-influenza_Chain 5127 12769, 20411, 28053, 35695, 43337, 50979, 58621 anti-influenza_Chain 5128 12770, 20412, 28054, 35696, 43338, 50980, 58622 anti-influenza_Chain 5129 12771, 20413, 28055, 35697, 43339, 50981, 58623 anti-influenza_Chain 5130 12772, 20414, 28056, 35698, 43340, 50982, 58624 anti-influenza_Chain 5131 12773, 20415, 28057, 35699, 43341, 50983, 58625 anti-influenza_Chain 5132 12774, 20416, 28058, 35700, 43342, 50984, 58626 anti-influenza_Chain 5133 12775, 20417, 28059, 35701, 43343, 50985, 58627 anti-influenza_Chain 5134 12776, 20418, 28060, 35702, 43344, 50986, 58628 anti-influenza_Chain 5135 12777, 20419, 28061, 35703, 43345, 50987, 58629 anti-influenza_Chain 5136 12778, 20420, 28062, 35704, 43346, 50988, 58630 anti-influenza_Chain 5137 12779, 20421, 28063, 35705, 43347, 50989, 58631 anti-influenza_Chain 5138 12780, 20422, 28064, 35706, 43348, 50990, 58632 anti-influenza_Chain 5139 12781, 20423, 28065, 35707, 43349, 50991, 58633 anti-influenza_Chain 5140 12782, 20424, 28066, 35708, 43350, 50992, 58634 anti-influenza_Chain 5141 12783, 20425, 28067, 35709, 43351, 50993, 58635 anti-influenza_Chain 5142 12784, 20426, 28068, 35710, 43352, 50994, 58636 anti-influenza_Chain 5143 12785, 20427, 28069, 35711, 43353, 50995, 58637 anti-influenza_Chain 5144 12786, 20428, 28070, 35712, 43354, 50996, 58638 anti-influenza_Chain 5145 12787, 20429, 28071, 35713, 43355, 50997, 58639 anti-influenza_Chain 5146 12788, 20430, 28072, 35714, 43356, 50998, 58640 anti-influenza_Chain 5147 12789, 20431, 28073, 35715, 43357, 50999, 58641 anti-influenza_Chain 5148 12790, 20432, 28074, 35716, 43358, 51000, 58642 anti-influenza_Chain 5149 12791, 20433, 28075, 35717, 43359, 51001, 58643 anti-influenza_Chain 5150 12792, 20434, 28076, 35718, 43360, 51002, 58644 anti-influenza_Chain 5151 12793, 20435, 28077, 35719, 43361, 51003, 58645 anti-influenza_Chain 5152 12794, 20436, 28078, 35720, 43362, 51004, 58646 anti-influenza_Chain 5153 12795, 20437, 28079, 35721, 43363, 51005, 58647 anti-influenza_Chain 5154 12796, 20438, 28080, 35722, 43364, 51006, 58648 anti-influenza_Chain 5155 12797, 20439, 28081, 35723, 43365, 51007, 58649 anti-influenza_Chain 5156 12798, 20440, 28082, 35724, 43366, 51008, 58650 anti-influenza_Chain 5157 12799, 20441, 28083, 35725, 43367, 51009, 58651 anti-influenza_Chain 5158 12800, 20442, 28084, 35726, 43368, 51010, 58652 anti-influenza_Chain 5159 12801, 20443, 28085, 35727, 43369, 51011, 58653 anti-influenza_Chain 5160 12802, 20444, 28086, 35728, 43370, 51012, 58654 anti-influenza_Chain 5161 12803, 20445, 28087, 35729, 43371, 51013, 58655 anti-influenza_Chain 5162 12804, 20446, 28088, 35730, 43372, 51014, 58656 anti-influenza_Chain 5163 12805, 20447, 28089, 35731, 43373, 51015, 58657 anti-influenza_Chain 5164 12806, 20448, 28090, 35732, 43374, 51016, 58658 anti-influenza_Chain 5165 12807, 20449, 28091, 35733, 43375, 51017, 58659 anti-influenza_Chain 5166 12808, 20450, 28092, 35734, 43376, 51018, 58660 anti-influenza_Chain 5167 12809, 20451, 28093, 35735, 43377, 51019, 58661 anti-influenza_Chain 5168 12810, 20452, 28094, 35736, 43378, 51020, 58662 anti-influenza_Chain 5169 12811, 20453, 28095, 35737, 43379, 51021, 58663 anti-influenza_Chain 5170 12812, 20454, 28096, 35738, 43380, 51022, 58664 anti-influenza_Chain 5171 12813, 20455, 28097, 35739, 43381, 51023, 58665 anti-influenza_Chain 5172 12814, 20456, 28098, 35740, 43382, 51024, 58666 anti-influenza_Chain 5173 12815, 20457, 28099, 35741, 43383, 51025, 58667 anti-influenza_Chain 5174 12816, 20458, 28100, 35742, 43384, 51026, 58668 anti-influenza_Chain 5175 12817, 20459, 28101, 35743, 43385, 51027, 58669 anti-influenza_Chain 5176 12818, 20460, 28102, 35744, 43386, 51028, 58670 anti-influenza_Chain 5177 12819, 20461, 28103, 35745, 43387, 51029, 58671 anti-influenza_Chain 5178 12820, 20462, 28104, 35746, 43388, 51030, 58672 anti-influenza_Chain 5179 12821, 20463, 28105, 35747, 43389, 51031, 58673 anti-influenza_Chain 5180 12822, 20464, 28106, 35748, 43390, 51032, 58674 anti-influenza_Chain 5181 12823, 20465, 28107, 35749, 43391, 51033, 58675 anti-influenza_Chain 5182 12824, 20466, 28108, 35750, 43392, 51034, 58676 anti-influenza_Chain 5183 12825, 20467, 28109, 35751, 43393, 51035, 58677 anti-influenza_Chain 5184 12826, 20468, 28110, 35752, 43394, 51036, 58678 anti-influenza_Chain 5185 12827, 20469, 28111, 35753, 43395, 51037, 58679 anti-influenza_Chain 5186 12828, 20470, 28112, 35754, 43396, 51038, 58680 anti-influenza_Chain 5187 12829, 20471, 28113, 35755, 43397, 51039, 58681 anti-influenza_Chain 5188 12830, 20472, 28114, 35756, 43398, 51040, 58682 anti-influenza_Chain 5189 12831, 20473, 28115, 35757, 43399, 51041, 58683 anti-influenza_Chain 5190 12832, 20474, 28116, 35758, 43400, 51042, 58684 anti-influenza_Chain 5191 12833, 20475, 28117, 35759, 43401, 51043, 58685 anti-influenza_Chain 5192 12834, 20476, 28118, 35760, 43402, 51044, 58686 anti-influenza_Chain 5193 12835, 20477, 28119, 35761, 43403, 51045, 58687 anti-influenza_Chain 5194 12836, 20478, 28120, 35762, 43404, 51046, 58688 anti-influenza_Chain 5195 12837, 20479, 28121, 35763, 43405, 51047, 58689 anti-influenza_Chain 5196 12838, 20480, 28122, 35764, 43406, 51048, 58690 anti-influenza_Chain 5197 12839, 20481, 28123, 35765, 43407, 51049, 58691 anti-influenza_Chain 5198 12840, 20482, 28124, 35766, 43408, 51050, 58692 anti-influenza_Chain 5199 12841, 20483, 28125, 35767, 43409, 51051, 58693 anti-influenza_Chain 5200 12842, 20484, 28126, 35768, 43410, 51052, 58694 anti-influenza_Chain 5201 12843, 20485, 28127, 35769, 43411, 51053, 58695 anti-influenza_Chain 5202 12844, 20486, 28128, 35770, 43412, 51054, 58696 anti-influenza_Chain 5203 12845, 20487, 28129, 35771, 43413, 51055, 58697 anti-influenza_Chain 5204 12846, 20488, 28130, 35772, 43414, 51056, 58698 anti-influenza_Chain 5205 12847, 20489, 28131, 35773, 43415, 51057, 58699 anti-influenza_Chain 5206 12848, 20490, 28132, 35774, 43416, 51058, 58700 anti-influenza_Chain 5207 12849, 20491, 28133, 35775, 43417, 51059, 58701 anti-influenza_Chain 5208 12850, 20492, 28134, 35776, 43418, 51060, 58702 anti-influenza_Chain 5209 12851, 20493, 28135, 35777, 43419, 51061, 58703 anti-influenza_Chain 5210 12852, 20494, 28136, 35778, 43420, 51062, 58704 anti-influenza_Chain 5211 12853, 20495, 28137, 35779, 43421, 51063, 58705 anti-influenza_Chain 5212 12854, 20496, 28138, 35780, 43422, 51064, 58706 anti-influenza_Chain 5213 12855, 20497, 28139, 35781, 43423, 51065, 58707 anti-influenza_Chain 5214 12856, 20498, 28140, 35782, 43424, 51066, 58708 anti-influenza_Chain 5215 12857, 20499, 28141, 35783, 43425, 51067, 58709 anti-influenza_Chain 5216 12858, 20500, 28142, 35784, 43426, 51068, 58710 anti-influenza_Chain 5217 12859, 20501, 28143, 35785, 43427, 51069, 58711 anti-influenza_Chain 5218 12860, 20502, 28144, 35786, 43428, 51070, 58712 anti-influenza_Chain 5219 12861, 20503, 28145, 35787, 43429, 51071, 58713 anti-influenza_Chain 5220 12862, 20504, 28146, 35788, 43430, 51072, 58714 anti-influenza_Chain 5221 12863, 20505, 28147, 35789, 43431, 51073, 58715 anti-influenza_Chain 5222 12864, 20506, 28148, 35790, 43432, 51074, 58716 anti-influenza_Chain 5223 12865, 20507, 28149, 35791, 43433, 51075, 58717 anti-influenza_Chain 5224 12866, 20508, 28150, 35792, 43434, 51076, 58718 anti-influenza_Chain 5225 12867, 20509, 28151, 35793, 43435, 51077, 58719 anti-influenza_Chain 5226 12868, 20510, 28152, 35794, 43436, 51078, 58720 anti-influenza_Chain 5227 12869, 20511, 28153, 35795, 43437, 51079, 58721 anti-influenza_Chain 5228 12870, 20512, 28154, 35796, 43438, 51080, 58722 anti-influenza_Chain 5229 12871, 20513, 28155, 35797, 43439, 51081, 58723 anti-influenza_Chain 5230 12872, 20514, 28156, 35798, 43440, 51082, 58724 anti-influenza_Chain 5231 12873, 20515, 28157, 35799, 43441, 51083, 58725 anti-influenza_Chain 5232 12874, 20516, 28158, 35800, 43442, 51084, 58726 anti-influenza_Chain 5233 12875, 20517, 28159, 35801, 43443, 51085, 58727 anti-influenza_Chain 5234 12876, 20518, 28160, 35802, 43444, 51086, 58728 anti-influenza_Chain 5235 12877, 20519, 28161, 35803, 43445, 51087, 58729 anti-influenza_Chain 5236 12878, 20520, 28162, 35804, 43446, 51088, 58730 anti-influenza_Chain 5237 12879, 20521, 28163, 35805, 43447, 51089, 58731 anti-influenza_Chain 5238 12880, 20522, 28164, 35806, 43448, 51090, 58732 anti-influenza_Chain 5239 12881, 20523, 28165, 35807, 43449, 51091, 58733 anti-influenza_Chain 5240 12882, 20524, 28166, 35808, 43450, 51092, 58734 anti-influenza_Chain 5241 12883, 20525, 28167, 35809, 43451, 51093, 58735 anti-influenza_Chain 5242 12884, 20526, 28168, 35810, 43452, 51094, 58736 anti-influenza_Chain 5243 12885, 20527, 28169, 35811, 43453, 51095, 58737 anti-influenza_Chain 5244 12886, 20528, 28170, 35812, 43454, 51096, 58738 anti-influenza_Chain 5245 12887, 20529, 28171, 35813, 43455, 51097, 58739 anti-influenza_Chain 5246 12888, 20530, 28172, 35814, 43456, 51098, 58740 anti-influenza_Chain 5247 12889, 20531, 28173, 35815, 43457, 51099, 58741 anti-influenza_Chain 5248 12890, 20532, 28174, 35816, 43458, 51100, 58742 anti-influenza_Chain 5249 12891, 20533, 28175, 35817, 43459, 51101, 58743 anti-influenza_Chain 5250 12892, 20534, 28176, 35818, 43460, 51102, 58744 anti-influenza_Chain 5251 12893, 20535, 28177, 35819, 43461, 51103, 58745 anti-influenza_Chain 5252 12894, 20536, 28178, 35820, 43462, 51104, 58746 anti-influenza_Chain 5253 12895, 20537, 28179, 35821, 43463, 51105, 58747 anti-influenza_Chain 5254 12896, 20538, 28180, 35822, 43464, 51106, 58748 anti-influenza_Chain 5255 12897, 20539, 28181, 35823, 43465, 51107, 58749 anti-influenza_Chain 5256 12898, 20540, 28182, 35824, 43466, 51108, 58750 anti-influenza_Chain 5257 12899, 20541, 28183, 35825, 43467, 51109, 58751 anti-influenza_Chain 5258 12900, 20542, 28184, 35826, 43468, 51110, 58752 anti-influenza_Chain 5259 12901, 20543, 28185, 35827, 43469, 51111, 58753 anti-influenza_Chain 5260 12902, 20544, 28186, 35828, 43470, 51112, 58754 anti-influenza_Chain 5261 12903, 20545, 28187, 35829, 43471, 51113, 58755 anti-influenza_Chain 5262 12904, 20546, 28188, 35830, 43472, 51114, 58756 anti-influenza_Chain 5263 12905, 20547, 28189, 35831, 43473, 51115, 58757 anti-influenza_Chain 5264 12906, 20548, 28190, 35832, 43474, 51116, 58758 anti-influenza_Chain 5265 12907, 20549, 28191, 35833, 43475, 51117, 58759 anti-influenza_Chain 5266 12908, 20550, 28192, 35834, 43476, 51118, 58760 anti-influenza_Chain 5267 12909, 20551, 28193, 35835, 43477, 51119, 58761 anti-influenza_Chain 5268 12910, 20552, 28194, 35836, 43478, 51120, 58762 anti-influenza_Chain 5269 12911, 20553, 28195, 35837, 43479, 51121, 58763 anti-influenza_Chain 5270 12912, 20554, 28196, 35838, 43480, 51122, 58764 anti-influenza_Chain 5271 12913, 20555, 28197, 35839, 43481, 51123, 58765 anti-influenza_Chain 5272 12914, 20556, 28198, 35840, 43482, 51124, 58766 anti-influenza_Chain 5273 12915, 20557, 28199, 35841, 43483, 51125, 58767 anti-influenza_Chain 5274 12916, 20558, 28200, 35842, 43484, 51126, 58768 anti-influenza_Chain 5275 12917, 20559, 28201, 35843, 43485, 51127, 58769 anti-influenza_Chain 5276 12918, 20560, 28202, 35844, 43486, 51128, 58770 anti-influenza_Chain 5277 12919, 20561, 28203, 35845, 43487, 51129, 58771 anti-influenza_Chain 5278 12920, 20562, 28204, 35846, 43488, 51130, 58772 anti-influenza_Chain 5279 12921, 20563, 28205, 35847, 43489, 51131, 58773 anti-influenza_Chain 5280 12922, 20564, 28206, 35848, 43490, 51132, 58774 anti-influenza_Chain 5281 12923, 20565, 28207, 35849, 43491, 51133, 58775 anti-influenza_Chain 5282 12924, 20566, 28208, 35850, 43492, 51134, 58776 anti-influenza_Chain 5283 12925, 20567, 28209, 35851, 43493, 51135, 58777 anti-influenza_Chain 5284 12926, 20568, 28210, 35852, 43494, 51136, 58778 anti-influenza_Chain 5285 12927, 20569, 28211, 35853, 43495, 51137, 58779 anti-influenza_Chain 5286 12928, 20570, 28212, 35854, 43496, 51138, 58780 anti-influenza_Chain 5287 12929, 20571, 28213, 35855, 43497, 51139, 58781 anti-influenza_Chain 5288 12930, 20572, 28214, 35856, 43498, 51140, 58782 anti-influenza_Chain 5289 12931, 20573, 28215, 35857, 43499, 51141, 58783 anti-influenza_Chain 5290 12932, 20574, 28216, 35858, 43500, 51142, 58784 anti-influenza_Chain 5291 12933, 20575, 28217, 35859, 43501, 51143, 58785 anti-influenza_Chain 5292 12934, 20576, 28218, 35860, 43502, 51144, 58786 anti-influenza_Chain 5293 12935, 20577, 28219, 35861, 43503, 51145, 58787 anti-influenza_Chain 5294 12936, 20578, 28220, 35862, 43504, 51146, 58788 anti-influenza_Chain 5295 12937, 20579, 28221, 35863, 43505, 51147, 58789 anti-influenza_Chain 5296 12938, 20580, 28222, 35864, 43506, 51148, 58790 anti-influenza_Chain 5297 12939, 20581, 28223, 35865, 43507, 51149, 58791 anti-influenza_Chain 5298 12940, 20582, 28224, 35866, 43508, 51150, 58792 anti-influenza_Chain 5299 12941, 20583, 28225, 35867, 43509, 51151, 58793 anti-influenza_Chain 5300 12942, 20584, 28226, 35868, 43510, 51152, 58794 anti-influenza_Chain 5301 12943, 20585, 28227, 35869, 43511, 51153, 58795 anti-influenza_Chain 5302 12944, 20586, 28228, 35870, 43512, 51154, 58796 anti-influenza_Chain 5303 12945, 20587, 28229, 35871, 43513, 51155, 58797 anti-influenza_Chain 5304 12946, 20588, 28230, 35872, 43514, 51156, 58798 anti-influenza_Chain 5305 12947, 20589, 28231, 35873, 43515, 51157, 58799 anti-influenza_Chain 5306 12948, 20590, 28232, 35874, 43516, 51158, 58800 anti-influenza_Chain 5307 12949, 20591, 28233, 35875, 43517, 51159, 58801 anti-influenza_Chain 5308 12950, 20592, 28234, 35876, 43518, 51160, 58802 anti-influenza_Chain 5309 12951, 20593, 28235, 35877, 43519, 51161, 58803 anti-influenza_Chain 5310 12952, 20594, 28236, 35878, 43520, 51162, 58804 anti-influenza_Chain 5311 12953, 20595, 28237, 35879, 43521, 51163, 58805 anti-influenza_Chain 5312 12954, 20596, 28238, 35880, 43522, 51164, 58806 anti-influenza_Chain 5313 12955, 20597, 28239, 35881, 43523, 51165, 58807 anti-influenza_Chain 5314 12956, 20598, 28240, 35882, 43524, 51166, 58808 anti-influenza_Chain 5315 12957, 20599, 28241, 35883, 43525, 51167, 58809 anti-influenza_Chain 5316 12958, 20600, 28242, 35884, 43526, 51168, 58810 anti-influenza_Chain 5317 12959, 20601, 28243, 35885, 43527, 51169, 58811 anti-influenza_Chain 5318 12960, 20602, 28244, 35886, 43528, 51170, 58812 anti-influenza_Chain 5319 12961, 20603, 28245, 35887, 43529, 51171, 58813 anti-influenza_Chain 5320 12962, 20604, 28246, 35888, 43530, 51172, 58814 anti-influenza_Chain 5321 12963, 20605, 28247, 35889, 43531, 51173, 58815 anti-influenza_Chain 5322 12964, 20606, 28248, 35890, 43532, 51174, 58816 anti-influenza_Chain 5323 12965, 20607, 28249, 35891, 43533, 51175, 58817 anti-influenza_Chain 5324 12966, 20608, 28250, 35892, 43534, 51176, 58818 anti-influenza_Chain 5325 12967, 20609, 28251, 35893, 43535, 51177, 58819 anti-influenza_Chain 5326 12968, 20610, 28252, 35894, 43536, 51178, 58820 anti-influenza_Chain 5327 12969, 20611, 28253, 35895, 43537, 51179, 58821 anti-influenza_Chain 5328 12970, 20612, 28254, 35896, 43538, 51180, 58822 anti-influenza_Chain 5329 12971, 20613, 28255, 35897, 43539, 51181, 58823 anti-influenza_Chain 5330 12972, 20614, 28256, 35898, 43540, 51182, 58824 anti-influenza_Chain 5331 12973, 20615, 28257, 35899, 43541, 51183, 58825 anti-influenza_Chain 5332 12974, 20616, 28258, 35900, 43542, 51184, 58826 anti-influenza_Chain 5333 12975, 20617, 28259, 35901, 43543, 51185, 58827 anti-influenza_Chain 5334 12976, 20618, 28260, 35902, 43544, 51186, 58828 anti-influenza_Chain 5335 12977, 20619, 28261, 35903, 43545, 51187, 58829 anti-influenza_Chain 5336 12978, 20620, 28262, 35904, 43546, 51188, 58830 anti-influenza_Chain 5337 12979, 20621, 28263, 35905, 43547, 51189, 58831 anti-influenza_Chain 5338 12980, 20622, 28264, 35906, 43548, 51190, 58832 anti-influenza_Chain 5339 12981, 20623, 28265, 35907, 43549, 51191, 58833 anti-influenza_Chain 5340 12982, 20624, 28266, 35908, 43550, 51192, 58834 anti-influenza_Chain 5341 12983, 20625, 28267, 35909, 43551, 51193, 58835 anti-influenza_Chain 5342 12984, 20626, 28268, 35910, 43552, 51194, 58836 anti-influenza_Chain 5343 12985, 20627, 28269, 35911, 43553, 51195, 58837 anti-influenza_Chain 5344 12986, 20628, 28270, 35912, 43554, 51196, 58838 anti-influenza_Chain 5345 12987, 20629, 28271, 35913, 43555, 51197, 58839 anti-influenza_Chain 5346 12988, 20630, 28272, 35914, 43556, 51198, 58840 anti-influenza_Chain 5347 12989, 20631, 28273, 35915, 43557, 51199, 58841 anti-influenza_Chain 5348 12990, 20632, 28274, 35916, 43558, 51200, 58842 anti-influenza_Chain 5349 12991, 20633, 28275, 35917, 43559, 51201, 58843 anti-influenza_Chain 5350 12992, 20634, 28276, 35918, 43560, 51202, 58844 anti-influenza_Chain 5351 12993, 20635, 28277, 35919, 43561, 51203, 58845 anti-influenza_Chain 5352 12994, 20636, 28278, 35920, 43562, 51204, 58846 anti-influenza_Chain 5353 12995, 20637, 28279, 35921, 43563, 51205, 58847 anti-influenza_Chain 5354 12996, 20638, 28280, 35922, 43564, 51206, 58848 anti-influenza_Chain 5355 12997, 20639, 28281, 35923, 43565, 51207, 58849 anti-influenza_Chain 5356 12998, 20640, 28282, 35924, 43566, 51208, 58850 anti-influenza_Chain 5357 12999, 20641, 28283, 35925, 43567, 51209, 58851 anti-influenza_Chain 5358 13000, 20642, 28284, 35926, 43568, 51210, 58852 anti-influenza_Chain 5359 13001, 20643, 28285, 35927, 43569, 51211, 58853 anti-influenza_Chain 5360 13002, 20644, 28286, 35928, 43570, 51212, 58854 anti-influenza_Chain 5361 13003, 20645, 28287, 35929, 43571, 51213, 58855 anti-influenza_Chain 5362 13004, 20646, 28288, 35930, 43572, 51214, 58856 anti-influenza_Chain 5363 13005, 20647, 28289, 35931, 43573, 51215, 58857 anti-influenza_Chain 5364 13006, 20648, 28290, 35932, 43574, 51216, 58858 anti-influenza_Chain 5365 13007, 20649, 28291, 35933, 43575, 51217, 58859 anti-influenza_Chain 5366 13008, 20650, 28292, 35934, 43576, 51218, 58860 anti-influenza_Chain 5367 13009, 20651, 28293, 35935, 43577, 51219, 58861 anti-influenza_Chain 5368 13010, 20652, 28294, 35936, 43578, 51220, 58862 anti-influenza_Chain 5369 13011, 20653, 28295, 35937, 43579, 51221, 58863 anti-influenza_Chain 5370 13012, 20654, 28296, 35938, 43580, 51222, 58864 anti-influenza_Chain 5371 13013, 20655, 28297, 35939, 43581, 51223, 58865 anti-influenza_Chain 5372 13014, 20656, 28298, 35940, 43582, 51224, 58866 anti-influenza_Chain 5373 13015, 20657, 28299, 35941, 43583, 51225, 58867 anti-influenza_Chain 5374 13016, 20658, 28300, 35942, 43584, 51226, 58868 anti-influenza_Chain 5375 13017, 20659, 28301, 35943, 43585, 51227, 58869 anti-influenza_Chain 5376 13018, 20660, 28302, 35944, 43586, 51228, 58870 anti-influenza_Chain 5377 13019, 20661, 28303, 35945, 43587, 51229, 58871 anti-influenza_Chain 5378 13020, 20662, 28304, 35946, 43588, 51230, 58872 anti-influenza_Chain 5379 13021, 20663, 28305, 35947, 43589, 51231, 58873 anti-influenza_Chain 5380 13022, 20664, 28306, 35948, 43590, 51232, 58874 anti-influenza_Chain 5381 13023, 20665, 28307, 35949, 43591, 51233, 58875 anti-influenza_Chain 5382 13024, 20666, 28308, 35950, 43592, 51234, 58876 anti-influenza_Chain 5383 13025, 20667, 28309, 35951, 43593, 51235, 58877 anti-influenza_Chain 5384 13026, 20668, 28310, 35952, 43594, 51236, 58878 anti-influenza_Chain 5385 13027, 20669, 28311, 35953, 43595, 51237, 58879 anti-influenza_Chain 5386 13028, 20670, 28312, 35954, 43596, 51238, 58880 anti-influenza_Chain 5387 13029, 20671, 28313, 35955, 43597, 51239, 58881 anti-influenza_Chain 5388 13030, 20672, 28314, 35956, 43598, 51240, 58882 anti-influenza_Chain 5389 13031, 20673, 28315, 35957, 43599, 51241, 58883 anti-influenza_Chain 5390 13032, 20674, 28316, 35958, 43600, 51242, 58884 anti-influenza_Chain 5391 13033, 20675, 28317, 35959, 43601, 51243, 58885 anti-influenza_Chain 5392 13034, 20676, 28318, 35960, 43602, 51244, 58886 anti-influenza_Chain 5393 13035, 20677, 28319, 35961, 43603, 51245, 58887 anti-influenza_Chain 5394 13036, 20678, 28320, 35962, 43604, 51246, 58888 anti-influenza_Chain 5395 13037, 20679, 28321, 35963, 43605, 51247, 58889 anti-influenza_Chain 5396 13038, 20680, 28322, 35964, 43606, 51248, 58890 anti-influenza_Chain 5397 13039, 20681, 28323, 35965, 43607, 51249, 58891 anti-influenza_Chain 5398 13040, 20682, 28324, 35966, 43608, 51250, 58892 anti-influenza_Chain 5399 13041, 20683, 28325, 35967, 43609, 51251, 58893 anti-influenza_Chain 5400 13042, 20684, 28326, 35968, 43610, 51252, 58894 anti-influenza_Chain 5401 13043, 20685, 28327, 35969, 43611, 51253, 58895 anti-influenza_Chain 5402 13044, 20686, 28328, 35970, 43612, 51254, 58896 anti-influenza_Chain 5403 13045, 20687, 28329, 35971, 43613, 51255, 58897 anti-influenza_Chain 5404 13046, 20688, 28330, 35972, 43614, 51256, 58898 anti-influenza_Chain 5405 13047, 20689, 28331, 35973, 43615, 51257, 58899 anti-influenza_Chain 5406 13048, 20690, 28332, 35974, 43616, 51258, 58900 anti-influenza_Chain 5407 13049, 20691, 28333, 35975, 43617, 51259, 58901 anti-influenza_Chain 5408 13050, 20692, 28334, 35976, 43618, 51260, 58902 anti-influenza_Chain 5409 13051, 20693, 28335, 35977, 43619, 51261, 58903 anti-influenza_Chain 5410 13052, 20694, 28336, 35978, 43620, 51262, 58904 anti-influenza_Chain 5411 13053, 20695, 28337, 35979, 43621, 51263, 58905 anti-influenza_Chain 5412 13054, 20696, 28338, 35980, 43622, 51264, 58906 anti-influenza_Chain 5413 13055, 20697, 28339, 35981, 43623, 51265, 58907 anti-influenza_Chain 5414 13056, 20698, 28340, 35982, 43624, 51266, 58908 anti-influenza_Chain 5415 13057, 20699, 28341, 35983, 43625, 51267, 58909 anti-influenza_Chain 5416 13058, 20700, 28342, 35984, 43626, 51268, 58910 anti-influenza_Chain 5417 13059, 20701, 28343, 35985, 43627, 51269, 58911 anti-influenza_Chain 5418 13060, 20702, 28344, 35986, 43628, 51270, 58912 anti-influenza_Chain 5419 13061, 20703, 28345, 35987, 43629, 51271, 58913 anti-influenza_Chain 5420 13062, 20704, 28346, 35988, 43630, 51272, 58914 anti-influenza_Chain 5421 13063, 20705, 28347, 35989, 43631, 51273, 58915 anti-influenza_Chain 5422 13064, 20706, 28348, 35990, 43632, 51274, 58916 anti-influenza_Chain 5423 13065, 20707, 28349, 35991, 43633, 51275, 58917 anti-influenza_Chain 5424 13066, 20708, 28350, 35992, 43634, 51276, 58918 anti-influenza_Chain 5425 13067, 20709, 28351, 35993, 43635, 51277, 58919 anti-influenza_Chain 5426 13068, 20710, 28352, 35994, 43636, 51278, 58920 anti-influenza_Chain 5427 13069, 20711, 28353, 35995, 43637, 51279, 58921 anti-influenza_Chain 5428 13070, 20712, 28354, 35996, 43638, 51280, 58922 anti-influenza_Chain 5429 13071, 20713, 28355, 35997, 43639, 51281, 58923 anti-influenza_Chain 5430 13072, 20714, 28356, 35998, 43640, 51282, 58924 anti-influenza_Chain 5431 13073, 20715, 28357, 35999, 43641, 51283, 58925 anti-influenza_Chain 5432 13074, 20716, 28358, 36000, 43642, 51284, 58926 anti-influenza_Chain 5433 13075, 20717, 28359, 36001, 43643, 51285, 58927 anti-influenza_Chain 5434 13076, 20718, 28360, 36002, 43644, 51286, 58928 anti-influenza_Chain 5435 13077, 20719, 28361, 36003, 43645, 51287, 58929 anti-influenza_Chain 5436 13078, 20720, 28362, 36004, 43646, 51288, 58930 anti-influenza_Chain 5437 13079, 20721, 28363, 36005, 43647, 51289, 58931 anti-influenza_Chain 5438 13080, 20722, 28364, 36006, 43648, 51290, 58932 anti-influenza_Chain 5439 13081, 20723, 28365, 36007, 43649, 51291, 58933 anti-influenza_Chain 5440 13082, 20724, 28366, 36008, 43650, 51292, 58934 anti-influenza_Chain 5441 13083, 20725, 28367, 36009, 43651, 51293, 58935 anti-influenza_Chain 5442 13084, 20726, 28368, 36010, 43652, 51294, 58936 anti-influenza_Chain 5443 13085, 20727, 28369, 36011, 43653, 51295, 58937 anti-influenza_Chain 5444 13086, 20728, 28370, 36012, 43654, 51296, 58938 anti-influenza_Chain 5445 13087, 20729, 28371, 36013, 43655, 51297, 58939 anti-influenza_Chain 5446 13088, 20730, 28372, 36014, 43656, 51298, 58940 anti-influenza_Chain 5447 13089, 20731, 28373, 36015, 43657, 51299, 58941 anti-influenza_Chain 5448 13090, 20732, 28374, 36016, 43658, 51300, 58942 anti-influenza_Chain 5449 13091, 20733, 28375, 36017, 43659, 51301, 58943 anti-influenza_Chain 5450 13092, 20734, 28376, 36018, 43660, 51302, 58944 anti-influenza_Chain 5451 13093, 20735, 28377, 36019, 43661, 51303, 58945 anti-influenza_Chain 5452 13094, 20736, 28378, 36020, 43662, 51304, 58946 anti-influenza_Chain 5453 13095, 20737, 28379, 36021, 43663, 51305, 58947 anti-influenza_Chain 5454 13096, 20738, 28380, 36022, 43664, 51306, 58948 anti-influenza_Chain 5455 13097, 20739, 28381, 36023, 43665, 51307, 58949 anti-influenza_Chain 5456 13098, 20740, 28382, 36024, 43666, 51308, 58950 anti-influenza_Chain 5457 13099, 20741, 28383, 36025, 43667, 51309, 58951 anti-influenza_Chain 5458 13100, 20742, 28384, 36026, 43668, 51310, 58952 anti-influenza_Chain 5459 13101, 20743, 28385, 36027, 43669, 51311, 58953 anti-influenza_Chain 5460 13102, 20744, 28386, 36028, 43670, 51312, 58954 anti-influenza_Chain 5461 13103, 20745, 28387, 36029, 43671, 51313, 58955 anti-influenza_Chain 5462 13104, 20746, 28388, 36030, 43672, 51314, 58956 anti-influenza_Chain 5463 13105, 20747, 28389, 36031, 43673, 51315, 58957 anti-influenza_Chain 5464 13106, 20748, 28390, 36032, 43674, 51316, 58958 anti-influenza_Chain 5465 13107, 20749, 28391, 36033, 43675, 51317, 58959 anti-influenza_Chain 5466 13108, 20750, 28392, 36034, 43676, 51318, 58960 anti-influenza_Chain 5467 13109, 20751, 28393, 36035, 43677, 51319, 58961 anti-influenza_Chain 5468 13110, 20752, 28394, 36036, 43678, 51320, 58962 anti-influenza_Chain 5469 13111, 20753, 28395, 36037, 43679, 51321, 58963 anti-influenza_Chain 5470 13112, 20754, 28396, 36038, 43680, 51322, 58964 anti-influenza_Chain 5471 13113, 20755, 28397, 36039, 43681, 51323, 58965 anti-influenza_Chain 5472 13114, 20756, 28398, 36040, 43682, 51324, 58966 anti-influenza_Chain 5473 13115, 20757, 28399, 36041, 43683, 51325, 58967 anti-influenza_Chain 5474 13116, 20758, 28400, 36042, 43684, 51326, 58968 anti-influenza_Chain 5475 13117, 20759, 28401, 36043, 43685, 51327, 58969 anti-influenza_Chain 5476 13118, 20760, 28402, 36044, 43686, 51328, 58970 anti-influenza_Chain 5477 13119, 20761, 28403, 36045, 43687, 51329, 58971 anti-influenza_Chain 5478 13120, 20762, 28404, 36046, 43688, 51330, 58972 anti-influenza_Chain 5479 13121, 20763, 28405, 36047, 43689, 51331, 58973 anti-influenza_Chain 5480 13122, 20764, 28406, 36048, 43690, 51332, 58974 anti-influenza_Chain 5481 13123, 20765, 28407, 36049, 43691, 51333, 58975 anti-influenza_Chain 5482 13124, 20766, 28408, 36050, 43692, 51334, 58976 anti-influenza_Chain 5483 13125, 20767, 28409, 36051, 43693, 51335, 58977 anti-influenza_Chain 5484 13126, 20768, 28410, 36052, 43694, 51336, 58978 anti-influenza_Chain 5485 13127, 20769, 28411, 36053, 43695, 51337, 58979 anti-influenza_Chain 5486 13128, 20770, 28412, 36054, 43696, 51338, 58980 anti-influenza_Chain 5487 13129, 20771, 28413, 36055, 43697, 51339, 58981 anti-influenza_Chain 5488 13130, 20772, 28414, 36056, 43698, 51340, 58982 anti-influenza_Chain 5489 13131, 20773, 28415, 36057, 43699, 51341, 58983 anti-influenza_Chain 5490 13132, 20774, 28416, 36058, 43700, 51342, 58984 anti-influenza_Chain 5491 13133, 20775, 28417, 36059, 43701, 51343, 58985 anti-influenza_Chain 5492 13134, 20776, 28418, 36060, 43702, 51344, 58986 anti-influenza_Chain 5493 13135, 20777, 28419, 36061, 43703, 51345, 58987 anti-influenza_Chain 5494 13136, 20778, 28420, 36062, 43704, 51346, 58988 anti-influenza_Chain 5495 13137, 20779, 28421, 36063, 43705, 51347, 58989 anti-influenza_Chain 5496 13138, 20780, 28422, 36064, 43706, 51348, 58990 anti-influenza_Chain 5497 13139, 20781, 28423, 36065, 43707, 51349, 58991 anti-influenza_Chain 5498 13140, 20782, 28424, 36066, 43708, 51350, 58992 anti-influenza_Chain 5499 13141, 20783, 28425, 36067, 43709, 51351, 58993 anti-influenza_Chain 5500 13142, 20784, 28426, 36068, 43710, 51352, 58994 anti-influenza_Chain 5501 13143, 20785, 28427, 36069, 43711, 51353, 58995 anti-influenza_Chain 5502 13144, 20786, 28428, 36070, 43712, 51354, 58996 anti-influenza_Chain 5503 13145, 20787, 28429, 36071, 43713, 51355, 58997 anti-influenza_Chain 5504 13146, 20788, 28430, 36072, 43714, 51356, 58998 anti-influenza_Chain 5505 13147, 20789, 28431, 36073, 43715, 51357, 58999 anti-influenza_Chain 5506 13148, 20790, 28432, 36074, 43716, 51358, 59000 anti-influenza_Chain 5507 13149, 20791, 28433, 36075, 43717, 51359, 59001 anti-influenza_Chain 5508 13150, 20792, 28434, 36076, 43718, 51360, 59002 anti-influenza_Chain 5509 13151, 20793, 28435, 36077, 43719, 51361, 59003 anti-influenza_Chain 5510 13152, 20794, 28436, 36078, 43720, 51362, 59004 anti-influenza_Chain 5511 13153, 20795, 28437, 36079, 43721, 51363, 59005 anti-influenza_Chain 5512 13154, 20796, 28438, 36080, 43722, 51364, 59006 anti-influenza_Chain 5513 13155, 20797, 28439, 36081, 43723, 51365, 59007 anti-influenza_Chain 5514 13156, 20798, 28440, 36082, 43724, 51366, 59008 anti-influenza_Chain 5515 13157, 20799, 28441, 36083, 43725, 51367, 59009 anti-influenza_Chain 5516 13158, 20800, 28442, 36084, 43726, 51368, 59010 anti-influenza_Chain 5517 13159, 20801, 28443, 36085, 43727, 51369, 59011 anti-influenza_Chain 5518 13160, 20802, 28444, 36086, 43728, 51370, 59012 anti-influenza_Chain 5519 13161, 20803, 28445, 36087, 43729, 51371, 59013 anti-influenza_Chain 5520 13162, 20804, 28446, 36088, 43730, 51372, 59014 anti-influenza_Chain 5521 13163, 20805, 28447, 36089, 43731, 51373, 59015 anti-influenza_Chain 5522 13164, 20806, 28448, 36090, 43732, 51374, 59016 anti-influenza_Chain 5523 13165, 20807, 28449, 36091, 43733, 51375, 59017 anti-influenza_Chain 5524 13166, 20808, 28450, 36092, 43734, 51376, 59018 anti-influenza_Chain 5525 13167, 20809, 28451, 36093, 43735, 51377, 59019 anti-influenza_Chain 5526 13168, 20810, 28452, 36094, 43736, 51378, 59020 anti-influenza_Chain 5527 13169, 20811, 28453, 36095, 43737, 51379, 59021 anti-influenza_Chain 5528 13170, 20812, 28454, 36096, 43738, 51380, 59022 anti-influenza_Chain 5529 13171, 20813, 28455, 36097, 43739, 51381, 59023 anti-influenza_Chain 5530 13172, 20814, 28456, 36098, 43740, 51382, 59024 anti-influenza_Chain 5531 13173, 20815, 28457, 36099, 43741, 51383, 59025 anti-influenza_Chain 5532 13174, 20816, 28458, 36100, 43742, 51384, 59026 anti-influenza_Chain 5533 13175, 20817, 28459, 36101, 43743, 51385, 59027 anti-influenza_Chain 5534 13176, 20818, 28460, 36102, 43744, 51386, 59028 anti-influenza_Chain 5535 13177, 20819, 28461, 36103, 43745, 51387, 59029 anti-influenza_Chain 5536 13178, 20820, 28462, 36104, 43746, 51388, 59030 anti-influenza_Chain 5537 13179, 20821, 28463, 36105, 43747, 51389, 59031 anti-influenza_Chain 5538 13180, 20822, 28464, 36106, 43748, 51390, 59032 anti-influenza_Chain 5539 13181, 20823, 28465, 36107, 43749, 51391, 59033 anti-0X40_LightChain 5540 13182, 20824, 28466, 36108, 43750, 51392, 59034 anti-0X40_LightChain 5541 13183, 20825, 28467, 36109, 43751, 51393, 59035 anti-0X40_LightChain 5542 13184, 20826, 28468, 36110, 43752, 51394, 59036 anti-0X40_LightChain 5543 13185, 20827, 28469, 36111, 43753, 51395, 59037 anti-0X40_LightChain 5544 13186, 20828, 28470, 36112, 43754, 51396, 59038 anti-0X40_LightChain 5545 13187, 20829, 28471, 36113, 43755, 51397, 59039 anti-0X40_LightChain 5546 13188, 20830, 28472, 36114, 43756, 51398, 59040 anti-0X40_LightChain 5547 13189, 20831, 28473, 36115, 43757, 51399, 59041 anti-0X40_LightChain 5548 13190, 20832, 28474, 36116, 43758, 51400, 59042 anti-0X40_LightChain 5549 13191, 20833, 28475, 36117, 43759, 51401, 59043 anti-0X40_LightChain 5550 13192, 20834, 28476, 36118, 43760, 51402, 59044 anti-0X40_LightChain 5551 13193, 20835, 28477, 36119, 43761, 51403, 59045 anti-0X40_LightChain 5552 13194, 20836, 28478, 36120, 43762, 51404, 59046 anti-0X40_LightChain 5553 13195, 20837, 28479, 36121, 43763, 51405, 59047 anti-0X40_HeavyChain 5554 13196, 20838, 28480, 36122, 43764, 51406, 59048 anti-0X40_HeavyChain 5555 13197, 20839, 28481, 36123, 43765, 51407, 59049 anti-0X40_HeavyChain 5556 13198, 20840, 28482, 36124, 43766, 51408, 59050 anti-0X40_HeavyChain 5557 13199, 20841, 28483, 36125, 43767, 51409, 59051 anti-0X40_HeavyChain 5558 13200, 20842, 28484, 36126, 43768, 51410, 59052 anti-0X40_HeavyChain 5559 13201, 20843, 28485, 36127, 43769, 51411, 59053 anti-0X40_HeavyChain 5560 13202, 20844, 28486, 36128, 43770, 51412, 59054 anti-0X40_HeavyChain 5561 13203, 20845, 28487, 36129, 43771, 51413, 59055 anti-0X40_HeavyChain 5562 13204, 20846, 28488, 36130, 43772, 51414, 59056 anti-0X40_HeavyChain 5563 13205, 20847, 28489, 36131, 43773, 51415, 59057 anti-0X40_HeavyChain 5564 13206, 20848, 28490, 36132, 43774, 51416, 59058 anti-0X40_HeavyChain 5565 13207, 20849, 28491, 36133, 43775, 51417, 59059 anti-0X40_HeavyChain 5566 13208, 20850, 28492, 36134, 43776, 51418, 59060 anti-0X40_HeavyChain 5567 13209, 20851, 28493, 36135, 43777, 51419, 59061 anti-0X40_HeavyChain 5568 13210, 20852, 28494, 36136, 43778, 51420, 59062 anti-0X40_HeavyChain 5569 13211, 20853, 28495, 36137, 43779, 51421, 59063 anti-0X40_HeavyChain 5570 13212, 20854, 28496, 36138, 43780, 51422, 59064 anti-0X40_HeavyChain 5571 13213, 20855, 28497, 36139, 43781, 51423, 59065 anti-0X40_HeavyChain 5572 13214, 20856, 28498, 36140, 43782, 51424, 59066 anti-0X40_HeavyChain 5573 13215, 20857, 28499, 36141, 43783, 51425, 59067 anti-0X40_HeavyChain 5574 13216, 20858, 28500, 36142, 43784, 51426, 59068 anti-0X40_HeavyChain 5575 13217, 20859, 28501, 36143, 43785, 51427, 59069 anti-0X40_HeavyChain 5576 13218, 20860, 28502, 36144, 43786, 51428, 59070 anti-0X40_HeavyChain 5577 13219, 20861, 28503, 36145, 43787, 51429, 59071 anti-0X40_HeavyChain 5578 13220, 20862, 28504, 36146, 43788, 51430, 59072 anti-0X40_HeavyChain 5579 13221, 20863, 28505, 36147, 43789, 51431, 59073 anti-0X40_HeavyChain 5580 13222, 20864, 28506, 36148, 43790, 51432, 59074 anti-0X40_HeavyChain 5581 13223, 20865, 28507, 36149, 43791, 51433, 59075 anti-0X40_HeavyChain 5582 13224, 20866, 28508, 36150, 43792, 51434, 59076 anti-0X40_HeavyChain 5583 13225, 20867, 28509, 36151, 43793, 51435, 59077 anti-0X40_HeavyChain 5584 13226, 20868, 28510, 36152, 43794, 51436, 59078 anti-0X40_HeavyChain 5585 13227, 20869, 28511, 36153, 43795, 51437, 59079 anti-0X40_HeavyChain 5586 13228, 20870, 28512, 36154, 43796, 51438, 59080 anti-0X40_HeavyChain 5587 13229, 20871, 28513, 36155, 43797, 51439, 59081 anti-0X40_HeavyChain 5588 13230, 20872, 28514, 36156, 43798, 51440, 59082 anti-0X40_LightChain 5589 13231, 20873, 28515, 36157, 43799, 51441, 59083 anti-0X40_LightChain 5590 13232, 20874, 28516, 36158, 43800, 51442, 59084 anti-0X40_LightChain 5591 13233, 20875, 28517, 36159, 43801, 51443, 59085 anti-0X40_LightChain 5592 13234, 20876, 28518, 36160, 43802, 51444, 59086 anti-0X40_LightChain 5593 13235, 20877, 28519, 36161, 43803, 51445, 59087 anti-0X40_HeavyChain 5594 13236, 20878, 28520, 36162, 43804, 51446, 59088 anti-0X40_HeavyChain 5595 13237, 20879, 28521, 36163, 43805, 51447, 59089 anti-0X40_HeavyChain 5596 13238, 20880, 28522, 36164, 43806, 51448, 59090 anti-0X40_HeavyChain 5597 13239, 20881, 28523, 36165, 43807, 51449, 59091 anti-0X40_HeavyChain 5598 13240, 20882, 28524, 36166, 43808, 51450, 59092 anti-0X40_LightChain 5599 13241, 20883, 28525, 36167, 43809, 51451, 59093 anti-0X40_HeavyChain 5600 13242, 20884, 28526, 36168, 43810, 51452, 59094

In a preferred embodiment the at least one coding sequence of the RNA according to the present invention encodes an antibody, i.e. in particular a full length (“complete”) antibody. In other words, it is preferred that a full length (“complete”) antibody is encoded by a single RNA (molecule). This may be realized by a monocistronic RNA (wherein heavy and light chain or fragments thereof such as the respective variable regions may, for example, be connected via a peptidic linker) or by a bi- or multicistronic RNA, wherein different fragments of the antibody, such as the heavy chain (or a fragment thereof, e.g. the heavy chain variable region) and the light chain (or a fragment thereof, e.g. the light chain variable region), are encoded in separate cistrons as described herein. It is also preferred that the at least one coding sequence of the RNA according to the present invention encodes a fragment of an antibody only, such as the heavy chain (or a fragment thereof, e.g. the heavy chain variable region) or the light chain (or a fragment thereof, e.g. the light chain variable region), with the corresponding fragment(s) required for a functional antibody being encoded by another RNA (molecule) according to the present invention.

For example, for the antibody abagovomab, the RNA according to the present invention may encode

-   (i) the heavy chain (amino acid sequence according to SEQ ID NO: 2),     for example by an RNA sequence according to any of SEQ ID NOs: 7644,     15286, 22928, 30570, 38212, 45854, 53496, or a fragment or variant     thereof; and -   (ii) the light chain (amino acid sequence according to SEQ ID NO:     3), for example by an RNA sequence according to any of SEQ ID NOs:     7645, 15287, 22929, 30571, 38213, 45855, 53497, or a fragment or     variant thereof     in a monocistronic (e.g., connected by a peptide linker) or in a     multicistronic, in particular bicistronic, manner as described     herein. Alternatively, the RNA according to the present invention     may encode the heavy chain (amino acid sequence according to SEQ ID     NO: 2), for example by an RNA sequence according to any of SEQ ID     NOs: 7644, 15286, 22928, 30570, 38212, 45854, 53496, or a fragment     or variant thereof, only and the corresponding light chain (amino     acid sequence according to SEQ ID NO: 3), for example by an RNA     sequence according to any of SEQ ID NOs: 7645, 15287, 22929, 30571,     38213, 45855, 53497, ora fragment or variant thereof, may be encoded     by a separate RNA (molecule). The latter option applies in     particular in the context of a combination according to the present     invention as described herein and of certain embodiments of the     composition and of the kit as described herein. In summary, by all     of the above options RNA encoding a (functional) antibody abagovomab     can be provided. Other antibodies may be provided in a similar     manner based on the information, which can be retrieved from Table     3.

Preferably, the at least one coding sequence of the RNA according to the present invention encodes an antibody or a fragment or variant thereof, in particular an antigen-binding fragment or variant thereof, as described above.

More preferably, the at least one coding sequence of the RNA according to the present invention encodes a heavy chain and/or a light chain of an antibody, or a fragment or variant of a heavy chain and/or of a light chain of an antibody, in particular an antigen-binding fragment or variant of a heavy chain and/or of a light chain of an antibody.

Even more preferably, the at least one coding sequence of the RNA according to the present invention encodes a heavy chain variable region and/or a light chain variable region of an antibody, or an antigen-binding fragment or variant of a heavy chain variable region and/or a light chain variable region of an antibody.

Table 4 below shows the amino acid positions of the heavy chain variable region and of the light chain variable region as well as of the heavy chain constant region and of the light chain constant region in the heavy chain and light chain amino acid sequences of exemplified antibodies, respectively. Those sequences of the heavy chain variable region and of the light chain variable region as well as of the heavy chain constant region and of the light chain constant region are preferably encoded by the RNA according to the present invention as described herein. In Table 4 a variable region of, for example, “1-119” means that amino acids 1-119 of the respective amino acid sequence (“Protein SEQ ID NO”) form the variable region. The first column identifies whether the amino acid sequence (“Protein SEQ ID NO”) is of the heavy chain or of the light chain. Accordingly, the skilled person can easily identify the heavy chain variable region, the light chain variable region as well as the heavy chain constant region and the light chain constant region of the exemplified antibodies based on the information in Table 4. Moreover, on basis of that information on amino acid sequence level, the skilled person can easily identify the corresponding RNA sequence fragments (i.e. the RNA sequences encoding the heavy chain/light chain constant region/variable region respectively), in particular by using the RNA sequences shown in Table 3 corresponding to the antibody of interest's amino acid sequence.

TABLE 4 Variable regions and constant regions of exemplified antibodies Protein SEQ ID Name NO Variable Region Constant Region AAB-003_gamma1-Chain 1 1-119 120-449 Abagovomab_HeavyChain 2 1-119 120-443 Abagovomab_LightChain 3 1-107 108-214 Abciximab_HeavyChain 4 1-119 120-450 Abciximab_LightChain 5 1-107 108-214 Abituzumab_HeavyChain1 6 1-118 119-447 Abituzumab_LightChain1 7 1-107 108-214 Abrilumab_HeavyChain1 8 1-118 119-444 Abrilumab_LightChain1 9 1-107 108-214 Abrilumab_LightChain1_variant2 10 1-106 107-213 Actoxumab_HeavyChain1 11 1-119 120-449 Actoxumab_LightChain1 12 1-108 109-215 Adalimumab_HeavyChain 13 1-121 122-224 Adalimumab_LightChain 14 1-107 108-214 Aducanumab_HeavyChain1 15 1-124 125-453 Aducanumab_LightChain1 16 1-107 108-214 Afasevikumab_HeavyChain1 17 1-123 124-453 Afasevikumab_LightChain1 18 1-108 109-215 Aflibercept_Fusion_protein1 19 1-120 121-431 Afutuzuab_HeavyChain1 20 1-117 118-444 Afutuzuab_LightChain1 21 1-110 111-217 Afutuzumab_HeavyChain1 22 1-119 120-449 Afutuzumab_LightChain1 23 1-112 113-219 Alacizumab_pegal_HeavyChain1 24 1-115 116-228 Alacizumab_pegal_LightChain1 25 1-107 108-214 Alemtuzumab_HeavyChain 26 1-121 122-451 Alemtuzumab_HeavyChain_variant_Ibey_H 27 1-121 122-219 Alemtuzumab_HeavyChain_variant_Icel_H 28 1-121 122-220 Alemtuzumab_HeavyChain_variant_8005_H 29 1-121 122-437 Alemtuzumab_LightChain 30 1-107 108-211 Alemtuzumab_LightChain_variant_8005_L 31 1-107 108-214 Alirucumab_HeavyChain1 32 1-118 119-447 Alirucumab_LightChain1 33 1-113 114-220 ALX-0061_HeavyChain1 34 1-121 122-245 Amatuximab_HeavyChain1 35 1-119 120-449 Amatuximab_LightChain1 36 1-106 107-213 Anetumab_ravtansine_HeavyChain1 37 1-120 121-450 Anetumab_ravtansine_LightChain1 38 1-111 112-217 Anifrolumab_HeavyChain1 39 1-117 118-447 Anifrolumab_LightChain1 40 1-108 109-215 Anrukinzumab_HeavyChain1 41 1-118 119-448 Anrukinzumab_LightChain1 42 1-111 112-218 Apolizumab_HeavyChain1 43 1-107 108-214 Apolizumab_LightChain1 44 1-116 117-446 Apomab_HeavyChain 45 1-120 121-126 Apomab_LightChain 46 1-108 109-108 Aquaporumab_LightChain 47 1-108 109-215 Arcitumomab_99tc_HeavyChain 48 1-121 122-442 Arcitumomab_99tc_LightChain 49 1-106 107-213 Ascrinvacumab_HeavyChain1 50 1-118 119-443 Ascrinvacumab_LightChain1 51 1-108 109-215 Aselizuab_HeavyChain1 52 1-114 115-438 Aselizuab_HeavyChain2 53 1-114 115-437 Aselizuab_LightChain1 54 1-109 110-216 Atezolizumab_HeavyChain1 55 1-118 119-448 Atezolizumab_LightChain1 56 1-107 108-214 Atinumab_HeavyChain1 57 1-114 115-441 Atinumab_LightChain1 58 1-107 108-214 Atlizuab_HeavyChain1 59 1-116 117-443 Atlizuab_LightChain1 60 1-106 107-213 Aurograb_SingleChain 61 1-123 124-264 Avelumab_HeavyChain1 62 1-120 121-450 Avelumab_LightChain1 63 1-110 111-216 Bapineuzumab_HeavyChain1 64 1-112 113-219 Bapineuzumab_LightChain1 65 1-119 120-448 Basiliximab_HeavyChain 66 1-115 116-446 Basiliximab_LightChain 67 1-104 105-210 Bavituximab_HeavyChain 68 1-120 121-456 Bavituximab_LightChain 69 1-107 108-214 Bavituximab_LightChain_variant_8734_L 70 1-107 108-208 Begelomab_HeavyChain1 71 1-120 121-459 Begelomab_LightChain1 72 1-106 107-213 Benralizumab_HeavyChain1 73 1-121 122-451 Benralizumab_LightChain1 74 1-107 108-214 Betalutin_HeavyChain1 75 1-107 108-214 Betalutin_LightChain1 76 1-119 120-443 Bevacituzuab_HeavyChain1 77 1-121 122-448 Bevacituzuab_LightChain1 78 1-106 107-213 Bevacizumab_154-aspartin_acid_LightChain 79 1-107 108-213 Bevacizumab_154-substitution_deriv_LightChain 80 1-107 108-213 Bevacizumab_180-serine_HeavyChain 81 1-123 124-224 Bevacizumab_180-substitution_deriv_HeavyChain 82 1-123 124-224 Bevacizumab_beta_HeavyChain1 83 1-123 124-453 Bevacizumab_beta_LightChain1 84 1-107 108-214 Bevacizumab_FcDomain 85 1-120 121-229 Bevacizumab_HeavyChain 86 1-123 124-224 Bevacizumab_HeavyChain_variant1 87 1-112 113-476 Bevacizumab_HeavyChain_V-Region 88 1-123 124-123 Bevacizumab_LightChain1 89 1-132 133-239 Bevacizumab_LightChain2 90 1-130 131-237 Bevacizumab_LightChain 91 1-107 108-214 Bevacizumab_LightChain_VJ-Region 92 1-107 108-108 Bevacizumab_LightChain_V-Region 93 1-107 108-107 Bevacizumab-rhuMAb-VEGF_HeavyChain_gamma1-Chain_VDJ- 94 1-123 124-123 Region Bevacizumab-rhuMAb-VEGF_LightChain_VJ-Region 95 1-107 108-107 Bevacizumab_gamma1-Chain 96 1-123 124-447 Bevacizumab_gamma1-Chain_CH3-Region_mutein 97 1-123 124-453 Bezlotuxumab_HeavyChain1 98 1-119 120-449 Bezlotuxumab_LightChain1 99 1-108 109-215 Bimagrumab_HeavyChain1 100 1-115 116-445 Bimagrumab_HeavyChain 101 1-115 116-444 Bimagrumab_LightChain1 102 1-111 112-217 Bimekizumab_HeavyChain1 103 1-125 126-455 Bimekizumab_LightChain1 104 1-107 108-214 Bleselumab_HeavyChain1 105 1-121 122-448 Bleselumab_LightChain1 106 1-106 107-213 Blinatumomab_HeavyChain1 107 1-111 112-504 Blinatumomab_SingleChain 108 1-111 112-505 Blinatumomab_SingleChain_variable_fragment_fusion_protein_(bite) 109 1-111 112-504 Blontuvetmab_HeavyChain 110 1-113 114-448 Blontuvetmab_LightChain 111 1-113 114-219 Blosozumab_HeavyChain1 112 1-118 119-444 Blosozumab_LightChain1 113 1-107 108-214 Bococizumab_HeavyChain1 114 1-118 119-444 Bococizumab_LightChain1 115 1-107 108-214 Brentuximab_vedutin_HeavyChain1 116 1-117 118-446 Brentuximab_vedutin_LightChain1 117 1-111 112-218 Briakinumab_HeavyChain1 118 1-115 116-445 Briakinumab_LightChain1 119 1-111 112-217 Brodalumab_HeavyChain1 120 1-116 117-442 Brodalumab_LightChain1 121 1-107 108-214 Brolucizumab_HeavyChain1 122 1-110 111-252 Brolucizumab_scfv_fragment 123 1-110 111-252 Bruntictuzumab_HeavyChain1 124 1-121 122-447 Bruntictuzumab_LightChain1 125 1-109 110-215 BTT-1023_HeavyChain1 126 1-117 118-444 BTT-1023_LightChain1 127 1-107 108-214 Burosumab_HeavyChain1 128 1-106 107-213 Burosumab_LightChain1 129 1-117 118-447 Canakinumab_HeavyChain1 130 1-119 120-455 Canakinumab_HeavyChain 131 1-118 119-448 Canakinumab_LightChain1 132 1-108 109-217 Canakinumab_LightChain 133 1-107 108-214 Canakinumab_LightChain_variant_8836_L 134 1-118 119-394 Cantuzumab_HeavyChain1 135 1-69   70-399 Cantuzumab_HeavyChain 136 1-119 120-449 Cantuzumab_LightChain1 137 1-112 113-219 Cantuzumab_mertansine_HeavyChain1 138 1-112 113-219 Cantuzumab_mertansine_LightChain1 139 1-119 120-448 Cantuzumab_ravtansine_HeavyChain1 140 1-119 120-449 Cantuzumab_ravtansine_LightChain1 141 1-112 113-219 Caplacizumab 142 1-120 121-259 Caplacizumab_HeavyChain1 143 1-120 121-259 Caplacizumab_HeavyChain1 144 1-120 121-259 Carlumab_HeavyChain1 145 1-119 120-449 Carlumab_LightChain1 146 1-109 110-216 Cergutuzumab_amunaleukin_HeavyChain1 147 1-121 122-451 Cergutuzumab_amunaleukin_HeavyChain2 148 1-121 122-599 Cergutuzumab_amunaleukin_LightChain1 149 1-108 109-215 Certolizumab_pegol_HeavyChain1 150 1-118 119-229 Certolizumab_pegol_HeavyChain 151 1-107 108-214 Certolizumab_pegol_LightChain1 152 1-107 108-214 Certolizumab_pegol_LightChain 153 1-118 119-229 Cetuximab_HeavyChain 154 1-119 120-452 Cetuximab_HeavyChain_variant 155 1-119 120-449 Cetuximab_LightChain 156 1-107 108-213 Cetuximab_LightChain_variant 157 1-107 108-214 Citatuzumab_bogatox_HeavyChain1 158 1-122 123-225 Citatuzumab_bogatox_LightChain1 159 1-112 113-481 Cixutumumab_HeavyChain1 160 1-130 131-460 Cixutumumab_LightChain1 161 1-108 109-214 Clazakizumab_HeavyChain1 162 1-120 121-450 Clazakizumab_LightChain1 163 1-110 111-217 Clivatuzumab_tetraxetan_HeavyChain1 164 1-119 120-449 Clivatuzumab_tetraxetan_LightChain1 165 1-108 108-215 Codrituzumab_HeavyChain1 166 1-115 116-445 Codrituzumab_LightChain1 167 1-112 113-216 Coltuximab_ravtansine_HeavyChain1 168 1-120 121-450 Coltuximab_ravtansine_LightChain1 169 1-104 105-211 Conatumumab_CV_HeavyChain 170 1-123 124-458 Conatumumab_CV_LightChain 171 1-109 110-218 Conatumumab_HeavyChain1 172 1-122 123-452 Conatumumab_HeavyChain 173 1-122 123-452 Conatumumab_LightChain1 174 1-108 109-215 Conatumumab_LightChain 175 1-108 109-215 Concizumab_HeavyChain1 176 1-121 122-448 Concizumab_LightChain1 177 1-112 113-219 Crenezumab_HeavyChain1 178 1-112 113-438 Crenezumab_LightChain1 179 1-112 113-219 Crotedumab_HeavyChain1 180 1-107 108-214 Crotedumab_HeavyChain2 181 1-107 109-214 Crotedumab_LightChain1 182 1-128 129-455 Crotedumab_LightChain2 183 1-128 129-455 Dacetuzumab_HeavyChain1 184 1-114 115-444 Dacetuzumab_LightChain1 185 1-112 113-219 Dacliximab_LightChain_VJ-Region 186 1-106 107-106 Dacliximab_gamma2-Chain_VDJ-Region 187 1-116 117-116 Daclizumab_HeavyChain 188 1-116 117-442 Daclizumab_LightChain 189 1-106 107-210 Dalotuzumab_HeavyChain1 190 1-117 118-447 Dalotuzumab_LightChain1 191 1-112 113-219 Dapirolizumab_pegol_HeavyChain1 192 1-118 119-229 Dapirolizumab_pegol_LightChain1 193 1-107 108-214 Daratumumab_HeavyChain1 194 1-122 123-452 Daratumumab_LightChain1 195 1-107 108-214 Dectrekumab_HeavyChain1 196 1-120 121-450 Dectrekumab_LightChain1 197 1-109 110-216 Demcizumab_HeavyChain1 198 1-119 120-444 Demcizumab_LightChain1 199 1-111 112-218 Denintuzumab_mafodotin_HeavyChain1 200 1-120 121-450 Denintuzumab_mafodotin_LightChain1 201 1-106 107-213 Denosumab_HeavyChain 202 1-122 123-452 Denosumab_LightChain 203 1-108 109-215 Depatuxizumab_HeavyChain1 204 1-107 108-214 Depatuxizumab_LightChain1 205 1-116 117-446 Depatuxizumab_mafodotin_HeavyChain1 206 1-107 108-214 Depatuxizumab_mafodotin_LightChain1 207 1-116 117-446 Dinutuximab_beta_HeavyChain1 208 1-113 114-443 Dinutuximab_beta_LightChain1 209 1-113 114-221 Dinutuximab_HeavyChain1 210 1-113 114-443 Dinutuximab_LightChain1 211 1-113 114-221 Dinutuximab_LightChain 212 1-113 114-220 Diridavumab_HeavyChain1 213 1-121 122-450 Diridavumab_LightChain1 214 1-111 112-217 Domagrozumab_HeavyChain1 215 1-116 117-446 Domagrozumab_HeavyChain 216 1-116 117-445 Domagrozumab_LightChain1 217 1-107 108-214 Drozituab_HeavyChain1 218 1-119 120-445 Drozituab_LightChain1 219 1-107 108-213 Drozitumab_HeavyChain1 220 1-121 122-451 Drozitumab_LightChain1 221 1-107 108-213 Duligotumab_HeavyChain1 222 1-121 122-451 Duligotumab_LightChain1 223 1-107 108-214 Duligotuzumab_HeavyChain1 224 1-121 122-451 Duligotuzumab_LightChain1 225 1-107 108-214 Dupilumab_HeavyChain1 226 1-125 126-451 Dupilumab_LightChain1 227 1-112 113-219 Durvalumab_HeavyChain1 228 1-121 122-451 Durvalumab_LightChain1 229 1-108 109-215 Dusigitumab_HeavyChain1 230 1-120 121-446 Dusigitumab_LightChain1 231 1-111 112-217 Ecromeximab_HeavyChain1 232 1-107 108-214 Ecromeximab_LightChain1 233 1-119 120-449 Eculizumab_HeavyChain1 234 1-107 108-214 Eculizumab_LightChain1 235 1-121 122-447 Efalizumab_HeavyChain 236 1-125 126-125 Efalizumab_LightChain 237 1-108 109-108 Efungumab_SingleChain_variable_fragment 238 1-122 123-256 Eldelumab_HeavyChain1 239 1-124 125-454 Eldelumab_LightChain1 240 1-109 110-216 Elgemtumab_HeavyChain1 241 1-117 118-447 Elgemtumab_LightChain1 242 1-107 108-214 Elotuzumab_HeavyChain1 243 1-119 120-449 Elotuzumab_LightChain1 244 1-107 108-214 Emactuzumab_HeavyChain1 245 1-116 117-446 Emactuzumab_LightChain1 246 1-106 107-213 Emibetuzumab_HeavyChain1 247 1-115 116-441 Emibetuzumab_LightChain1 248 1-108 109-215 Emicizumab_HeavyChain1 249 1-123 124-448 Emicizumab_HeavyChain2 250 1-119 120-444 Emicizumab_LightChain1 251 1-107 108-214 Enavatuzumab_HeavyChain1 252 1-119 120-449 Enavatuzumab_LightChain1 253 1-111 112-218 Enfortumab_HeavyChain 254 1-117 118-447 Enfortumab_LightChain 255 1-107 108-214 Enfortumab_vedotin_HeavyChain1 256 1-117 118-447 Enfortumab_vedotin_LightChain1 257 1-107 108-214 Enoblituzumab_HeavyChain 258 1-122 123-452 Enoblituzumab_LightChain 259 1-107 108-214 Enokizumab_HeavyChain1 260 1-122 123-452 Enokizumab_LightChain1 261 1-107 108-214 Enokizumab_LightChain 262 1-107 108-204 Enoticumab_HeavyChain1 263 1-123 124-452 Enoticumab_LightChain1 264 1-107 108-214 Ensituximab_HeavyChain1 265 1-113 114-443 Ensituximab_LightChain1 266 1-166 107-213 Ensituximab_SingleChain_variable_fragment 267 1-122 123-256 Entolimod_chain1 268 1-120 121-329 Epratuzumab_HeavyChain 269 1-116 117-446 Epratuzumab_LightChain 270 1-112 113-219 Eptacog_beta_HeavyChain1 271 1-120 121-255 Eptacog_beta_LightChain1 272 1-107 108-152 Erlizuab_HeavyChain1 273 1-119 120-236 Erlizuab_LightChain1 274 1-106 107-213 Etaracizumab_HeavyChain1 275 1-117 118-447 Etaracizumab_LightChain1 276 1-107 108-214 Etrolizuab_HeavyChain1 277 1-116 117-442 Etrolizuab_HeavyChain2 278 1-116 117-442 Etrolizuab_LightChain1 279 1-106 107-213 Etrolizumab_HeavyChain1 280 1-117 118-446 Etrolizumab_LightChain1 281 1-107 108-214 Evinacumab_HeavyChain1 282 1-126 127-453 Evinacumab_LightChain1 283 1-107 108-214 Evolocumab_HeavyChain1 284 1-115 116-441 Evolocumab_LightChain1 285 1-109 110-215 Exbivirumab_HeavyChain1 286 1-121 122-451 Exbivirumab_LightChain1 287 1-108 109-214 Farletuzumab_HeavyChain1 288 1-119 120-449 Farletuzumab_LightChain1 289 1-110 111-217 Fasinumab_HeavyChain1 290 1-119 120-446 Fasinumab_LightChain1 291 1-107 108-214 Fezakinumab_HeavyChain1 292 1-121 122-450 Fezakinumab_LightChain1 293 1-111 112-217 FG-3019_HeavyChain1 294 1-107 108-214 FG-3019_LightChain1 295 1-120 121-449 Fibatuzumab_HeavyChain1 296 1-118 119-448 Fibatuzumab_LightChain1 297 1-107 108-214 Ficlatuzumab_HeavyChain1 298 1-118 119-448 Ficlatuzumab_HeavyChain 299 1-117 118-447 Ficlatuzumab_LightChain1 300 1-107 108-214 Figitumumab_HeavyChain1 301 1-125 126-450 Figitumumab_LightChain1 302 1-107 108-214 Firivumab_HeavyChain1 303 1-123 124-453 Firivumab_LightChain1 304 1-107 108-214 Flanvotumab_HeavyChain1 305 1-119 120-449 Flanvotumab_LightChain1 306 1-108 109-215 Fletikumab_HeavyChain1 307 1-127 128-454 Fletikumab_LightChain1 308 1-107 108-214 Fontolizumab_HeavyChain1 309 1-107 108-214 Fontolizumab_LightChain1 310 1-117 118-447 Foralumab_HeavyChain1 311 1-118 119-448 Foralumab_LightChain1 312 1-108 109-215 Foravirumab_HeavyChain1 313 1-119 120-448 Foravirumab_HeavyChain 314 1-119 120-448 Foravirumab_LightChain1 315 1-107 108-214 Fresolimumab_HeavyChain1 316 1-120 121-447 Fresolimumab_LightChain1 317 1-108 109-215 Fulranumab_HeavyChain1 318 1-123 124-449 Fulranumab_LightChain1 319 1-107 108-214 Futuximab_HeavyChain1 320 1-123 124-452 Futuximab_LightChain1 321 1-107 108-214 Galcanezumab_HeavyChain1 322 1-119 120-445 Galcanezumab_LightChain1 323 1-107 108-214 Galiximab_HeavyChain1 324 1-110 111-216 Galiximab_LightChain1 325 1-127 128-457 Ganitumab_HeavyChain1 326 1-119 120-449 Ganitumab_LightChain1 327 1-112 113-219 Gantenerumab_HeavyChain1 328 1-126 127-456 Gantenerumab_LightChain1 329 1-108 109-215 Gemtuzumab_HeavyChain1 330 1-116 117-116 Gemtuzumab_HeavyChain2 331 1-117 118-117 Gemtuzumab_LightChain2 332 1-107 108-107 Gemtuzumab_ozogamicin_LightChain1 333 1-106 107-106 Gevokizumab_HeavyChain1 334 1-120 121-445 Gevokizumab_LightChain1 335 1-107 108-214 Girentuximab_HeavyChain1 336 1-119 120-449 Girentuximab_LightChain1 337 1-107 108-214 Glembatumumab_HeavyChain1 338 1-119 120-445 Glembatumumab_LightChain1 339 1-108 109-215 Goilixiab_HeavyChain1 340 1-116 117-444 Goilixiab_LightChain1 341 1-106 107-213 Guselkumab_HeavyChain1 342 1-117 118-446 Guselkumab_LightChain1 343 1-111 112-217 HuMab-001_HeavyChain_VDJ-Region 344 1-120 121-120 HuMab-001_LightChain_VJ-Region 345 1-107 108-107 HuMab-005_HeavyChain_gamma-Chain_VDJ-Region 346 1-122 123-122 HuMab-005_LightChain_VJ-Region 347 1-107 108-107 HuMab-006_HeavyChain_VDJ-Region 348 1-119 120-119 HuMab-006_LightChain_VJ-Region 349 1-108 109-108 HuMab-019_HeavyChain_VDJ-Region 350 1-120 121-120 HuMab-021_HeavyChain_VDJ-Region 351 1-120 121-120 HuMab-021_LightChain_VJ-Region 352 1-107 108-107 HuMab-025_HeavyChain_VDJ-Region 353 1-120 121-120 HuMab-025_LightChain_VJ-Region 354 1-107 108-107 HuMab-027_HeavyChain_VDJ-Region 355 1-120 121-120 HuMab-032_HeavyChain_VDJ-Region 356 1-120 121-120 HuMab-032_LightChain_VJ-Region 357 1-107 108-107 HuMab-033_HeavyChain_VDJ-Region 358 1-121 122-121 HuMab-035_HeavyChain_VDJ-Region 359 1-120 121-120 HuMab-036_HeavyChain_VDJ-Region 360 1-120 121-120 HuMab-036_LightChain_VJ-Region 361 1-107 108-107 HuMab-041_HeavyChain_VDJ-Region 362 1-122 123-122 HuMab-044_HeavyChain_VDJ-Region 363 1-122 123-122 HuMab-049_HeavyChain_VDJ-Region 364 1-119 120-119 HuMab-049_LightChain_VJ-Region 365 1-107 108-107 HuMab-050_HeavyChain_VDJ-Region 366 1-119 120-119 HuMab-050_LightChain_VJ-Region 367 1-107 108-107 HuMab-054_HeavyChain_VDJ-Region 368 1-120 121-120 HuMab-054_LightChain_VJ-Region 369 1-107 108-107 HuMab-055_HeavyChain_VDJ-Region 370 1-119 120-119 HuMab-059_HeavyChain_VDJ-Region 371 1-122 123-122 HuMab-059_LightChain_VJ-Region 372 1-108 109-108 HuMab-060_HeavyChain_VDJ-Region 373 1-122 123-122 HuMab-060_LightChain_VJ-Region 374 1-109 110-109 HuMab-067_HeavyChain_VDJ-Region 375 1-122 123-122 HuMab-072_HeavyChain_VDJ-Region 376 1-122 123-122 HuMab-072_LightChain_VJ-Region 377 1-109 110-109 HuMab-084_HeavyChain_VDJ-Region 378 1-121 122-121 HuMab-084_LightChain_VJ-Region 379 1-107 108-107 HuMab-091_HeavyChain_VDJ-Region 380 1-120 121-120 HuMab-091_LightChain_VJ-Region 381 1-107 108-107 HuMab-093_HeavyChain_VDJ-Region 382 1-122 123-122 HuMab-098_HeavyChain_VDJ-Region 383 1-124 125-124 HuMab-098_LightChain_VJ-Region 384 1-107 108-107 HuMab-100_HeavyChain_VDJ-Region 385 1-124 125-124 HuMab-106_HeavyChain_VDJ-Region 386 1-124 125-124 HuMab-106_LightChain_VJ-Region 387 1-107 108-107 HuMab_10F8_HeavyChain_V-Region 388 1-117 118-117 HuMab_10F8_HeavyChain_V-Region_Precursor 389 1-136 137-136 HuMab_10F8_LightChain_V-Region 390 1-107 108-107 HuMab_10F8_LightChain_V-Region_Precursor 391 1-127 128-127 HuMab-111_HeavyChain_VDJ-Region 392 1-119 120-119 HuMab-111_LightChain_VJ-Region 393 1-107 108-107 HuMab-123_HeavyChain_VDJ-Region 394 1-121 122-121 HuMab-123_LightChain_VJ-Region 395 1-107 108-107 HuMab-124_HeavyChain_VDJ-Region 396 1-121 122-121 HuMab-125_HeavyChain_VDJ-Region 397 1-124 125-124 HuMab-125_LightChain_VJ-Region 398 1-107 108-107 HuMab-127_HeavyChain_VDJ-Region 399 1-123 124-123 HuMab-127_LightChain_VJ-Region 400 1-107 108-107 HuMab-129_HeavyChain_VDJ-Region 401 1-119 120-119 HuMab-129_LightChain_VJ-Region 402 1-106 107-106 HuMab-132_HeavyChain_VDJ-Region 403 1-125 126-125 HuMab-132_LightChain_VJ-Region 404 1-108 109-108 HuMab-143_HeavyChain_VDJ-Region 405 1-120 121-120 HuMab-143_LightChain_VJ-Region 406 1-107 108-107 HuMab-150_HeavyChain_VDJ-Region 407 1-122 123-122 HuMab-150_LightChain_VJ-Region 408 1-107 108-107 HuMab-152_HeavyChain_VDJ-Region 409 1-121 122-121 HuMab-152_LightChain_VJ-Region 410 1-107 108-107 HuMab-153_HeavyChain_VDJ-Region 411 1-121 122-121 HuMab-153_LightChain_VJ-Region 412 1-107 108-107 HuMab-159_HeavyChain_VDJ-Region 413 1-126 127-126 HuMab-159_LightChain_VJ-Region 414 1-107 108-107 HuMab-160_HeavyChain_VDJ-Region 415 1-121 122-121 HuMab-160_LightChain_VJ-Region 416 1-107 108-107 HuMab-162_HeavyChain_VDJ-Region 417 1-124 125-124 HuMab-162_LightChain_VJ-Region 418 1-107 108-107 HuMab-163_HeavyChain_VDJ-Region 419 1-122 123-122 HuMab-163_LightChain_VJ-Region 420 1-107 108-107 HuMab-166_HeavyChain_VDJ-Region 421 1-121 122-121 HuMab-166_LightChain_VJ-Region 422 1-107 108-107 HuMab-167_HeavyChain_VDJ-Region 423 1-121 122-121 HuMab-169_HeavyChain_VDJ-Region 424 1-121 122-121 HuMab-169_LightChain_VJ-Region 425 1-107 108-107 HuMab-708_HeavyChain_VH-Region 426 1-122 123-122 HuMab-708_HeavyChain_V-Region 427 1-122 123-122 HuMab-708_LightChain_VL-Region 428 1-107 108-107 HuMab-708_LightChain_V-Region 429 1-107 108-107 huMAb-anti-MSP10.1_LightChain_VJ-Region 430 1-108 109-108 huMAb-anti-MSP10.2_LightChain_VJ-Region 431 1-108 109-108 HUMAB-Clone_18_VJ-Region 432 1-108 109-108 HUMAB-Clone_22_VJ-Region 433 1-108 109-108 HuMab-LG12_μChain_VDJ-Region_Precursor 434 1-139 140-144 HuMab_LC5002-002_LightChain_V-Region 435 1-107 108-107 HuMab_LC5002-002_gamma1-Chain_V-Region 436 1-119 120-119 HuMab_LC5002-003_LightChain_V-Region 437 1-107 108-107 HuMab_LC5002-003_gamma1-Chain_V-Region 438 1-119 120-119 HuMab_LC5002-005_LightChain_V-Region 439 1-107 108-107 HuMab_LC5002-005_gamma1-Chain_V-Region 440 1-118 119-118 HuMab_LC5002-007_LightChain_V-Region 441 1-107 108-107 HuMab_LC5002-007_gamma1-Chain_V-Region 442 1-123 124-123 HuMab_LC5002-018_gamma1-Chain_V-Region 443 1-119 120-119 Ibalizumab_HeavyChain1 444 1-122 123-449 Ibalizumab_LightChain1 445 1-112 113-219 Ibritumomab_tiuxetan_HeavyChain 446 1-122 123-443 Ibritumomab_tiuxetan_LightChain 447 1-106 107-209 Icrunumab_HeavyChain1 448 1-126 127-456 Icrunumab_LightChain1 449 1-108 109-215 Idarucizumab_HeavyChain1 450 1-122 123-225 Idarucizumab_LightChain1 451 1-112 113-219 Igatuzuab_HeavyChain1 452 1-120 121-444 Igatuzuab_LightChain1 453 1-105 106-212 IGF-IR_HUMAB-1A_HeavyChain 454 1-119 120-119 IGF-IR_HUMAB-23_HeavyChain 455 1-119 120-119 IGF-IR_HUMAB-23_LightChain 456 1-107 108-107 IGF-IR_HUMAB-8_HeavyChain 457 1-119 120-119 IGF-IR_HUMAB-8_LightChain 458 1-107 108-107 ImAb1_LightChain 459 1-129 130-236 ImAb1_gamma1-Chain 460 1-133 134-227 Imalumab_HeavyChain1 461 1-118 119-448 Imalumab_LightChain1 462 1-107 108-214 Imgatuzumab_HeavyChain1 463 1-120 121-449 Imgatuzumab_LightChain1 464 1-106 107-213 Inclacumab_HeavyChain1 465 1-124 125-451 Inclacumab_LightChain1 466 1-107 108-214 Indatuximab_ravtansine_HeavyChain1 467 1-122 123-449 Indatuximab_ravtansine_LightChain1 468 1-107 108-214 Indusatumab_vedotin_HeavyChain1 469 1-119 120-449 Indusatumab_vedotin_LightChain1 470 1-107 108-214 Inebilizumab_HeavyChain1 471 1-121 122-451 Inebilizumab_LightChain1 472 1-111 112-218 Insulin_peglispro_Fragment1 473 1-30  31-30 Insulin_peglispro_Fragment2 474 1-21  22-21 Interferon_beta-1b_chain1 475 1-120 121-165 Intetumumab_HeavyChain1 476 1-119 120-449 Intetumumab_LightChain1 477 1-108 109-215 Iodine_(1241)_Girentuximab_HeavyChain1 478 1-119 120-449 Iodine_(1241)_Girentuximab_LightChain1 479 1-107 108-214 Iodine_(1311)_Derlotuxiab_biotin_HeavyChain1 480 1-117 118-445 Iodine_(1311)_Derlotuxiab_biotin_LightChain1 481 1-106 107-213 Iodine_(1311)_Derlotuximab_biotin_HeavyChain1 482 1-120 121-450 Iodine_(1311)_Derlotuximab_biotin_LightChain1 483 1-108 109-215 Ipilimumab_HeavyChain 484 1-118 119-448 Ipilimumab_LightChain 485 1-108 109-215 Iratumumab_HeavyChain1 486 1-107 108-107 Iratumumab_LightChain1 487 1-62  63-62 Isatuximab_HeavyChain1 488 1-120 121-450 Isatuximab_LightChain1 489 1-107 108-214 Itolizumab_HeavyChain1 490 1-119 120-449 Itolizumab_LightChain1 491 1-107 108-214 Ixekizumab_HeavyChain1 492 1-119 120-445 Ixekizumab_LightChain1 493 1-112 113-219 Labetuzumab_govitecan_HeavyChain1 494 1-119 120-449 Labetuzumab_govitecan_LightChain1 495 1-106 107-213 Lambrolizumab_HeavyChain1 496 1-120 121-447 Lambrolizumab_LightChain1 497 1-111 112-218 Lampalizumab_HeavyChain1 498 1-115 116-223 Lampalizumab_LightChain1 499 1-107 108-214 Lanadelumab_HeavyChain1 500 1-122 123-451 Lanadelumab_LightChain1 501 1-106 107-213 Landogrozumab_HeavyChain1 502 1-113 114-439 Landogrozumab_LightChain1 503 1-108 109-215 Laprituximab_emtansine_HeavyChain1 504 1-119 120-448 Laprituximab_emtansine_LightChain1 505 1-107 108-214 Lealesoab_HeavyChain1 506 1-119 120-438 Lealesoab_LightChain1 507 1-112 113-218 Lebrikizumab_HeavyChain1 508 1-120 121-445 Lebrikizumab_LightChain1 509 1-111 112-218 Lenercept_chain1 510 1-120 121-409 Lenzilumab_HeavyChain1 511 1-119 120-449 Lenzilumab_LightChain1 512 1-107 108-214 Lerdelimumab_HeavyChain1 513 1-115 116-442 Lerdelimumab_LightChain1 514 1-109 110-215 Lexatumumab_HeavyChain1 515 1-122 123-457 Lexatumumab_HeavyChain 516 1-121 122-451 Lexatumumab_LightChain1 517 1-109 110-217 Lexatumumab_LightChain 518 1-108 109-214 Libivirumab_HeavyChain1 519 1-112 113-219 Libivirumab_LightChain1 520 1-129 130-459 Lifastuzumab_HeavyChain 521 1-120 121-450 Lifastuzumab_LightChain 522 1-112 113-219 Lifastuzumab_vedotin_HeavyChain1 523 1-119 120-449 Lifastuzumab_vedotin_LightChain1 524 1-112 113-219 Ligelizumab_HeavyChain1 525 1-123 124-453 Ligelizumab_LightChain1 526 1-107 108-214 Lilotomab_HeavyChain1 527 1-119 120-443 Lilotomab_LightChain1 528 1-107 108-214 Lintuzumab_HeavyChain1 529 1-111 112-218 Lintuzumab_LightChain1 530 1-116 117-446 Lirilumab_HeavyChain1 531 1-123 124-450 Lirilumab_LightChain1 532 1-107 108-214 Lodelcizumab_HeavyChain1 533 1-118 119-448 Lodelcizumab_LightChain1 534 1-106 107-213 Lokivetmab_HeavyChain1 535 1-118 119-452 Lokivetmab_LightChain1 536 1-111 112-217 Lorvotuzumab_mertansine_HeavyChain1 537 1-118 119-448 Lorvotuzumab_mertansine_LightChain1 538 1-112 113-219 Lpathomab_VL 539 1-112 113-112 Lpathomab_gamma1-Chain_VDJ-Region 540 1-122 123-122 Lucatumumab_HeavyChain1 541 1-120 121-450 Lucatumumab_LightChain1 542 1-112 113-219 Lulizumab_pegol_LightChain1 543 1-109 110-109 Lulizumab_pegol_LightChain 544 1-108 109-108 Lumiliximab_HeavyChain1 545 1-107 108-214 Lumiliximab_LightChain1 546 1-68   69-398 Lumretuzumab_HeavyChain1 547 1-120 121-449 Lumretuzumab_LightChain1 548 1-113 114-221 Lutetium_(177Lu)_lilotomab_satetraxetan_HeavyChain1 549 1-119 120-443 Lutetium_(177Lu)_lilotomab_satetraxetan_LightChain1 550 1-107 108-214 Margetuximab_HeavyChain1 551 1-120 121-450 Margetuximab_LightChain1 552 1-107 108-214 Marzeptacog_alfa_HeavyChain1 553 1-120 121-254 Marzeptacog_alfa_LightChain1 554 1-107 108-152 Matuzumab_HeavyChain1_variant_3c08_H 555 1-121 122-223 Matuzumab_HeavyChain1_variant_3c09_C 556 1-121 122-223 Matuzumab_LightChain1_variant_3c08_L 557 1-106 107-212 Matuzumab_LightChain1_variant_3c09_B 558 1-106 107-212 Mavrilimumab_HeavyChain1 559 1-120 121-447 Mavrilimumab_LightChain1 560 1-111 112-217 MDX-1303_HeavyChain1 561 1-108 109-215 MDX-1303_LightChain1 562 1-123 124-453 Mepolizumab_HeavyChain1 563 1-113 114-220 Mepolizumab_LightChain1 564 1-119 120-449 Metelimumab_HeavyChain1 565 1-107 108-213 Metelimumab_LightChain1 566 1-123 124-450 Milatuzumab_HeavyChain1 567 1-120 121-450 Milatuzumab_LightChain1 568 1-112 113-219 Mirvetuximab_HeavyChain1 569 1-118 119-447 Mirvetuximab_LightChain1 570 1-111 112-218 Modotuximab_HeavyChain1 571 1-119 120-448 Modotuximab_LightChain1 572 1-112 113-219 Mogamulizumab_HeavyChain1 573 1-119 120-449 Mogamulizumab_LightChain1 574 1-112 113-219 Monalizumab_HeavyChain1 575 1-125 129-452 Monalizumab_LightChain1 576 1-107 108-214 Motavizumab_HeavyChain 577 1-120 121-450 Motavizumab_HeavyChain_variant 578 1-120 121-450 Motavizumab_LightChain 579 1-106 107-213 Motavizumab_LightChain_variant 580 1-106 107-213 Moxetumomab_pasudotox_HeavyChain1 581 1-120 121-476 Moxetumomab_pasudotox_LightChain1 582 1-108 109-108 Muromonab-CD3_HeavyChain 583 1-119 120-450 Muromonab-CD3_LightChain 584 1-106 107-213 Namilumab_HeavyChain1 585 1-119 120-449 Namilumab_LightChain1 586 1-107 108-214 Naptumomab_estafenatox_HeavyChain 587 1-120 121-458 Naptumomab_estafenatox_LightChain 588 1-107 108-214 Narnatumab_HeavyChain1 589 1-122 123-452 Narnatumab_LightChain1 590 1-107 108-214 Natalizumab_HeavyChain1 591 1-106 107-213 Natalizumab_LightChain1 592 1-123 124-450 Navicixizumab_HeavyChain1 593 1-119 120-445 Navicixizumab_HeavyChain2 594 1-121 122-447 Navicixizumab_LightChain1 595 1-111 112-218 Navivumab_HeavyChain1 596 1-126 127-459 Navivumab_LightChain1 597 1-108 109-215 Ndimab-varB_HeavyChain 598 1-126 127-724 Ndimab-varB_LightChain 599 1-108 109-215 Necitumumab_HeavyChain1 600 1-121 122-451 Necitumumab_LightChain1 601 1-107 108-214 Neliximab_HeavyChain_VH-Region 602 1-124 125-132 Neliximab_HeavyChain_VH-Region_variant1 603 1-124 125-124 Neliximab_LightChain_VL-Region 604 1-106 107-106 Neliximab_LightChain_VL-Region_variant1 605 1-106 107-118 Nemolizumab_HeavyChain1 606 1-121 122-445 Nemolizumab_LightChain1 607 1-107 108-214 Nesvacumab_HeavyChain1 608 1-122 123-452 Nesvacumab_LightChain1 609 1-107 108-214 Neuradiab_HeavyChain1 610 1-112 113-219 Neuradiab_LightChain1 611 1-118 119-454 Nimotuzumab_HeavyChain1 612 1-114 115-114 Nimotuzumab_LightChain1 613 1-123 124-123 Nivolumab_HeavyChain1 614 1-113 114-440 Nivolumab_LightChain1 615 1-107 108-214 Obiltoxaximab_HeavyChain1 616 1-119 120-449 Obiltoxaximab_LightChain1 617 1-107 108-214 Obinutuzumab_HeavyChain1 618 1-119 120-449 Obinutuzumab_LightChain1 619 1-112 113-219 Ocaratuzumab_HeavyChain1 620 1-121 122-450 Ocaratuzumab_LightChain1 621 1-106 107-213 Ocrelizumab_HeavyChain1 622 1-106 107-213 Ocrelizumab_LightChain1 623 1-122 123-452 Ofatumumab_HeavyChain1 624 1-107 108-214 Ofatumumab_LightChain1 625 1-122 123-452 Olaratumab_HeavyChain1 626 1-127 128-457 Olaratumab_LightChain1 627 1-107 108-214 Olizuab_HeavyChain1 628 1-120 121-447 Olizuab_LightChain1 629 1-110 111-217 Olokizumab_HeavyChain1 630 1-120 121-447 Olokizumab_LightChain1 631 1-107 108-214 Omalizumab_HeavyChain 632 1-121 122-447 Omalizumab_LightChain 633 1-111 112-215 Onartuzumab_HeavyChain1 634 1-119 120-449 Onartuzumab_HeavyChain2 635 1-120 121-227 Onartuzumab_LightChain1 636 1-113 114-220 Ontuxizumab_HeavyChain1 637 1-124 125-454 Ontuxizumab_LightChain1 638 1-108 109-215 Opicinumab_HeavyChain1 639 1-118 119-447 Opicinumab_LightChain1 640 1-108 109-215 Oportuzumab_monatox_HeavyChain1 641 1-118 119-648 Oportuzumab_monatox_SingleChain_variable_fragment 642 1-118 119-647 Oreptacog_alfa_HeavyChain1 643 1-120 121-254 Oreptacog_alfa_LightChain1 644 1-107 108-152 Orticumab_HeavyChain1 645 1-121 122-451 Orticumab_LightChain1 646 1-110 111-216 Otelixizumab_HeavyChain1 647 1-119 120-449 Otelixizumab_LightChain1 648 1-110 111-216 Otlertuzumab_HeavyChain1 649 1-116 117-483 Oxelumab_HeavyChain1 650 1-120 121-449 Oxelumab_LightChain1 651 1-107 108-214 Ozanezumab_HeavyChain1 652 1-113 114-443 Ozanezumab_LightChain1 653 1-112 113-219 Ozoralizumab_HeavyChain1 654 1-115 116-363 Palivizumab_HeavyChain 655 1-120 121-450 Palivizumab_LightChain 656 1-106 107-213 Palivizumab_VH-Region 657 1-120 121-120 Pamrevlumab_HeavyChain1 658 1-120 121-449 Pamrevlumab_LightChain1 659 1-107 108-214 Panitumumab_HeavyChain1 660 1-107 108-214 Panitumumab_LightChain1 661 1-119 120-435 Pankoab_HeavyChain1 662 1-114 115-442 Pankoab_LightChain1 663 1-110 111-217 Pankoab_LightChain2 664 1-110 111-217 PankoMab_HeavyChain_VDJ-Region 665 1-117 118-117 PankoMab_LightChain_VJ-Region 666 1-112 113-113 Panobacumab_HeavyChain1 667 1-116 117-570 Panobacumab_LightChain1 668 1-112 113-219 Panobacumab_LightChain2 669 1-120 121-138 Parsatuzumab_HeavyChain1 670 1-123 124-453 Parsatuzumab_LightChain1 671 1-112 113-219 Pascolizumab_HeavyChain1 672 1-111 112-218 Pascolizumab_LightChain1 673 1-121 122-451 Pasotuxizumab_HeavyChain1 674 1-121 122-504 Pasotuxizumab_SingleChain 675 1-121 122-505 Pateclizumab_HeavyChain1 676 1-118 119-447 Pateclizumab_LightChain1 677 1-107 108-214 Patritumab_HeavyChain1 678 1-117 118-447 Patritumab_hinge-CH2—CH3 679 1-120 121-227 Patritumab_LightChain1 680 1-113 114-220 Pembrolizumab_HeavyChain1 681 1-120 121-447 Pembrolizumab_LightChain1 682 1-111 112-218 Perakizumab_HeavyChain1 683 1-122 123-452 Perakizumab_LightChain1 684 1-108 109-215 Pertuzuab_HeavyChain1 685 1-117 118-444 Pertuzuab_LightChain1 686 1-106 107-213 Pertuzumab_HeavyChain 687 1-107 108-214 Pertuzumab_LightChain 688 1-119 120-448 Pexelizumab_h5g1.1-scFv 689 1-111 112-250 Pexelizumab_h5g1.1VHC_+_F_Heavy_Chain_V-Region 690 1-115 116-115 Pexelizumab_h5g1.1VHC_+_F_Light_Chain_V-Region 691 1-106 107-106 PF-05082566_HeavyChain1 692 1-116 117-442 PF-05082568_LightChain1 693 1-108 109-214 Pidilizumab_HeavyChain1 694 1-117 118-447 Pidilizumab_LightChain1 695 1-106 107-213 Pinatuzumab_vedotin_HeavyChain1 696 1-120 121-450 Pinatuzumab_vedotin_LightChain1 697 1-112 113-219 Placulumab_chain1 698 1-107 108-341 Placulumab_HeavyChain1 699 1-107 108-341 Plozalizumab_HeavyChain1 700 1-117 118-447 Plozalizumab_LightChain1 701 1-112 113-219 Pogalizumab_HeavyChain1 702 1-117 118-447 Pogalizumab_LightChain1 703 1-107 108-214 Polatuzumab_vedotin_HeavyChain1 704 1-117 118-447 Polatuzumab_vedotin_LightChain1 705 1-111 112-218 Ponezumab_HeavyChain1 706 1-116 117-442 Ponezumab_LightChain1 707 1-112 113-219 Pritoxaximab_HeavyChain1 708 1-122 123-454 Pritoxaximab_LightChain1 709 1-107 108-214 Pritumumab_HeavyChain1 710 1-107 108-214 Pritumumab_LightChain1 711 1-120 121-450 Quilizumab_HeavyChain1 712 1-117 118-447 Quilizumab_LightChain1 713 1-112 113-219 Racotumomab_HeavyChain1 714 1-121 122-445 Racotumomab_LightChain1 715 1-107 108-214 Racotumomab_scVH-VH′-VH_chain 716 1-115 116-363 Radretumab_HeavyChain1 717 1-116 117-357 Radretumab_j_chain 718 1-120 121-138 Rafivirumab_HeavyChain1 719 1-127 128-456 Rafivirumab_HeavyChain 720 1-127 128-456 Rafivirumab_LightChain1 721 1-112 113-218 Rafivirumab_LightChain 722 1-112 113-218 Ralpancizumab_HeavyChain1 723 1-118 119-444 Ralpancizumab_LightChain1 724 1-107 108-214 Ramucirumab_HeavyChain1 725 1-116 117-446 Ramucirumab_LightChain1 726 1-107 108-214 Ranibiziuab_HeavyChain1 727 1-121 122-229 Ranibiziuab_LightChain1 728 1-107 108-214 Ranibizumab_fab_fragment 729 1-107 108-213 Ranibizumab_HeavyChain 730 1-123 124-231 Ranibizumab_LightChain 731 1-123 124-218 Ranibizumab_LightChain_variant 732 1-107 108-214 Refanezumab_HeavyChain1 733 1-126 127-456 Refanezumab_LightChain1 734 1-112 113-219 REGN2810_HeavyChain1 735 1-115 116-438 REGN2810_LightChain1 736 1-106 107-213 rhuMab_HER2(9CI)_LightChain 737 1-110 111-217 rhuMab_HER2_HeavyChain 738 1-74   75-405 rhuMab_HER2_LightChain 739 1-107 108-214 rhuMab_HER2_LightChain_variant1 740 1-106 107-106 rhuMab_HER2_LightChain_variant2 741 1-107 108-214 rhuMab_HER2_LightChain_variant3 742 1-107 108-214 rhuMab_HER2_LightChain_variant4 743 1-108 109-215 rhuMab_HER2_LightChain_V-Region 744 1-107 108-107 rhuMab_HER2_gamma1-Chain 745 1-120 121-450 rhuMab_HER2_gamma1-Chain 746 1-120 121-450 rhuMab_HER2_gamma1-Chain_rhuMab_HER2_LightChain_sc405 747 1-120 121-243 rhuMab_HER2_gamma1-Chain_variant1 748 1-120 121-450 rhuMab_HER2_gamma1-Chain_variant2 749 1-120 121-450 rhuMab_HER2_gamma1-Chain_variant3 750 1-120 121-450 rhuMab_HER2_gamma1-Chain_V-Region 751 1-120 121-120 rhuMAb-VEGF_HeavyChain1 752 1-123 124-453 rhuMAb-VEGF_LightChain1 753 1-107 108-214 rhuMAb-VEGF_LightChain 754 1-107 108-214 rhuMAb-VEGF_LightChain_VG-Region 755 1-107 108-107 rhuMAb-VEGF_gamma1-Chain 756 1-123 124-453 rhuMAb-VEGF_gamma1-Chain_VDG-Region 757 1-123 124-123 Rilotumumab_HeavyChain1 758 1-120 121-446 Rilotumumab_LightChain1 759 1-108 109-215 Rilotumumab_scFv-CH_chain 760 1-116 117-357 Rinucumab_HeavyChain1 761 1-122 123-449 Rinucumab_HeavyChain 762 1-122 123-448 Rinucumab_LightChain1 763 1-108 109-215 Risankizumab_HeavyChain1 764 1-120 121-449 Risankizumab_LightChain1 765 1-107 108-214 Rituximab_HeavyChain 766 1-121 122-451 Rituximab_HeavyChain_variant 767 1-121 122-451 Rituximab_LightChain 768 1-106 107-213 Rivabazumab_pegol_HeavyChain1 769 1-124 125-238 Rivabazumab_pegol_LightChain1 770 1-107 108-214 Robatumumab_HeavyChain1 771 1-118 119-448 Robatumumab_LightChain1 772 1-107 108-214 Roledumab_HeavyChain1 773 1-126 127-456 Roledumab_LightChain1 774 1-107 108-214 Romosozumab_fab_fragment 775 1-107 108-213 Romosozumab_HeavyChain1 776 1-123 124-449 Romosozumab_LightChain1 777 1-107 108-214 Rontalizuab_HeavyChain1 778 1-116 117-442 Rontalizuab_LightChain1 779 1-109 110-216 Rontalizumab_HeavyChain1 780 1-117 118-447 Rontalizumab_LightChain1 781 1-111 112-218 Rovalpituzumab_tesirine_HeavyChain1 782 1-118 119-447 Rovalpituzumab_tesirine_LightChain1 783 1-107 108-214 Rovelizumab_HeavyChain1 784 1-111 112-218 Rovelizumab_LightChain1 785 1-120 121-447 Ruplizumab_HeavyChain1 786 1-111 112-218 Ruplizumab_LightChain1 787 1-118 119-447 Sacituzumab_govitecan_HeavyChain1 788 1-121 122-451 Sacituzumab_govitecan_LightChain1 789 1-107 108-214 Samalizumab_HeavyChain1 790 1-117 118-442 Samalizumab_LightChain1 791 1-107 108-214 Sarilumab_HeavyChain1 792 1-116 117-446 Sarilumab_LightChain1 793 1-107 108-214 Satumomab_pendetide_HeavyChain 794 1-114 115-432 Satumomab_pendetide_LightChain 795 1-107 108-210 Secukinumab_HeavyChain1 796 1-127 128-457 Secukinumab_LightChain1 797 1-108 109-215 Seribantumab_HeavyChain1 798 1-119 120-445 Seribantumab_LightChain1 799 1-111 112-217 Setoxaximab_HeavyChain1 800 1-121 122-451 Setoxaximab_LightChain1 801 1-113 114-220 Sifalimumab_HeavyChain1 802 1-116 117-446 Sifalimumab_LightChain1 803 1-108 109-215 Siltuximab_HeavyChain1 804 1-119 120-449 Siltuximab_LightChain1 805 1-106 107-213 Simtuzumab_HeavyChain1 806 1-116 117-443 Simtuzumab_LightChain1 807 1-112 113-219 Sirukumab_HeavyChain1 808 1-119 120-449 Sirukumab_LightChain1 809 1-106 107-213 Sofituzumab_vedotin_HeavyChain1 810 1-116 117-446 Sofituzumab_vedotin_LightChain1 811 1-107 108-214 Solanezumab_HeavyChain1 812 1-112 113-441 Solanezumab_HeavyChain 813 1-112 113-442 Solanezumab_LightChain1 814 1-112 113-219 Solitomab_HeavyChain1 815 1-113 114-502 Solitomab_SingleChain 816 1-113 114-503 Sonepcizumab_LightChain_Precursor 817 1-127 128-234 Sonepcizumab_gamma1-Chain_Precursor 818 1-140 141-455 Stamulumab_HeavyChain1 819 1-105 106-211 Stamulumab_LightChain1 820 1-117 118-446 Suptavumab_HeavyChain1 821 1-107 108-214 Suptavumab_LightChain1 822 1-123 124-452 Suvizumab_HeavyChain1 823 1-118 119-448 Suvizumab_LightChain1 824 1-113 114-220 Tabalumab_HeavyChain1 825 1-123 124-450 Tabalumab_LightChain1 826 1-107 108-214 Tacatuzuab_HeavyChain1 827 1-117 118-444 Tacatuzuab_LightChain1 828 1-105 106-212 Tadocizumab_fab_fragment_HeavyChain 829 1-119 120-226 Tadocizumab_fab_fragment_LightChain 830 1-107 108-194 Talizumab_HeavyChain1 831 1-107 108-214 Talizumab_LightChain1 832 1-123 124-453 Tamtuvetmab_HeavyChain1 833 1-107 108-213 Tamtuvetmab_LightChain1 834 1-121 122-456 Tanezumab_HeavyChain 835 1-120 121-120 Tanezumab_LightChain 836 1-107 108-109 Tarextumab_HeavyChain1 837 1-115 116-441 Tarextumab_LightChain1 838 1-108 109-215 Tefibazumab_HeavyChain1 839 1-112 113-112 Tefibazumab_LightChain1 840 1-121 122-121 Tenatumomab_HeavyChain1 841 1-120 121-456 Tenatumomab_LightChain1 842 1-112 113-219 Teneliximab_HeavyChain1 843 1-107 108-214 Teneliximab_LightChain1 844 1-122 123-452 Teplizumab_HeavyChain1 845 1-119 120-449 Teplizumab_LightChain1 846 1-106 107-213 Teprotumumab_HeavyChain1 847 1-118 119-448 Teprotumumab_LightChain1 848 1-108 109-215 Tesidolumab_HeavyChain1 849 1-116 117-446 Tesidolumab_LightChain1 850 1-108 109-214 Tezepelumab_HeavyChain1 851 1-122 123-448 Tezepelumab_LightChain1 852 1-108 109-214 ThioMAb-chMA79b-HC(A118C)_HeavyChain 853 1-117 118-446 ThioMab-hu10A8.v1-HC(A118C)_HeavyChain 854 1-119 120-449 ThioMab-hu10A8.v1-HC(V205C)_HeavyChain 855 1-119 120-449 ThioMab-hu10A8.v1-LC(A118C)_LightChain 856 1-107 108-214 ThioMab-hu10A8.v1-LC(V205C)_LightChain 857 1-107 108-214 ThioMAb-huMA79b.v17-HC(A118C)_HeavyChain 858 1-117 118-446 ThioMAb-huMA79b.v17-HC(A118C)_LightChain 859 1-111 112-218 ThioMAb-huMA79b.v18-HC(A118C)_HeavyChain 860 1-117 118-446 ThioMAb-huMA79b.v28-HC(A118C)_LightChain 861 1-111 112-218 ThioMAb-huMA79b.v28-LC(V205C)_LightChain 862 1-111 112-218 Ticiliuab_HeavyChain1 863 1-122 123-444 Ticiliuab_LightChain1 864 1-106 107-213 Tigatuzumab_HeavyChain1 865 1-119 120-449 Tigatuzumab_HeavyChain 866 Tigatuzumab_LightChain1 867 1-106 107-213 Tigatuzumab_LightChain 868 1-107 108-216 Tildrakizumab_HeavyChain1 869 1-116 117-446 Tildrakizumab_LightChain1 870 1-107 108-214 Tisotumab_vedotin_HeavyChain1 871 1-118 119-448 Tisotumab_vedotin_LightChain1 872 1-107 108-214 Tocilizumab_HeavyChain1 873 1-107 108-214 Tocilizumab_LightChain1 874 1-119 120-447 Tosatoxumab_HeavyChain1 875 1-121 122-451 Tosatoxumab_LightChain1 876 1-111 112-217 Tositumomab_HeavyChain 877 1-123 124-447 Tositumomab_LightChain 878 1-106 107-210 Tovetumab_HeavyChain1 879 1-120 121-446 Tovetumab_LightChain1 880 1-108 109-215 Tralokinumab_HeavyChain1 881 1-122 123-449 Tralokinumab_LightChain1 882 1-108 109-214 Trastuzuab_HeavyChain1 883 1-118 119-444 Trastuzuab_LightChain1 884 Trastuzumab_emtansine_HeavyChain1 885 1-120 121-449 Trastuzumab_emtansine_LightChain1 886 1-107 108-214 Trastuzumab_HeavyChain1 887 Trastuzumab_HeavyChain 888 1-120 121-451 Trastuzumab_HeavyChain_variant_In8z_B 889 1-120 121-220 Trastuzumab_HeavyChain_variant_7637_H 890 1-15  Trastuzumab_LightChain1 891 1-107 108-214 Trastuzumab_LightChain_variant_In8z_A 892 1-107 108-214 Trastuzumab_LightChain_variant_7637_L 893 1-107 108-214 TRC-105_HeavyChain1 894 1-118 119-448 TRC-105_LightChain1 895 1-106 107-213 Tregalizumab_HeavyChain1 896 1-124 125-454 Tregalizumab_LightChain1 897 1-111 112-218 Tremelimumab_HeavyChain1 898 1-107 108-214 Tremelimumab_LightChain1 899 1-125 126-451 Trevogrumab_HeavyChain1 900 1-120 121-447 Trevogrumab_LightChain1 901 1-107 108-214 Tucotuzumab_celmoleukin_HeavyChain1 902 1-106 107-213 Tucotuzumab_celmoleukin_LightChain1 903 1-116 117-579 Ublituximab_HeavyChain1 904 1-118 119-448 Ublituximab_LightChain1 905 1-106 107-213 Ulocuplumab_HeavyChain1 906 1-125 126-451 Ulocuplumab_LightChain1 907 1-107 108-214 Urelumab_HeavyChain1 908 1-121 122-448 Urelumab_LightChain1 909 1-107 108-216 Urtoxazumab_HeavyChain1 910 1-107 108-214 Urtoxazumab_LightChain1 911 1-119 120-449 Ustekinumab_HeavyChain1 912 1-107 108-214 Ustekinumab_LightChain1 913 1-119 120-449 Vadastuximab_talirine_HeavyChain1 914 1-117 118-447 Vadastuximab_talirine_LightChain1 915 1-107 108-214 Vandortuzumab_vedotin_HeavyChain1 916 1-124 125-454 Vandortuzumab_vedotin_LightChain1 917 1-113 114-221 Vantictumab_HeavyChain1 918 1-118 119-443 Vantictumab_LightChain1 919 1-107 108-213 Vanucizumab_HeavyChain1 920 1-129 130-463 Vanucizumab_HeavyChain2 921 1-123 124-453 Vanucizumab_LightChain1 922 1-110 111-213 Vanucizumab_LightChain2 923 1-107 108-214 Varlilumab_HeavyChain1 924 1-119 120-452 Varlilumab_LightChain1 925 1-107 108-214 Vatelizumab_HeavyChain1 926 1-119 120-446 Vatelizumab_LightChain1 927 1-106 107-213 Vedolizumab_HeavyChain1 928 1-121 122-451 Vedolizumab_LightChain1 929 1-112 113-219 Veltuzumab_HeavyChain1 930 1-121 122-451 Veltuzumab_LightChain1 931 1-106 107-213 Vesencumab_HeavyChain1 932 1-123 124-453 Vesencumab_LightChain1 933 1-107 108-214 Visilizumab_HeavyChain1 934 1-106 107-213 Visilizumab_LightChain1 935 1-120 121-446 Volociximab_HeavyChain 936 1-124 125-451 Volociximab_LightChain 937 1-108 109-215 Vorsetuzumab_HeavyChain1 939 1-118 119-448 Vorsetuzumab_LightChain1 939 1-111 112-218 Vorsetuzumab_mafodotin_HeavyChain1 940 1-118 119-448 Vorsetuzumab_mafodotin_LightChain1 941 1-111 112-218 Yttrium_(90Y)_clivatuzumab_tetraxetan_HeavyChain1 942 1-119 120-449 Yttrium_(90Y)_clivatuzumab_tetraxetan_LightChain1 943 1-108 109-215 Yttrium_Y_90_epratuzumab_tetraxetan_HeavyChain1 944 1-112 113-219 Yttrium_Y_90_epratuzumab_tetraxetan_LightChain1 945 1-116 117-446 Yttrium_Y_90_epratuzumab_HeavyChain1 946 1-115 116-442 Yttrium_Y_90_epratuzumab_LightChain1 947 1-111 112-218 Zalutumumab_HeavyChain1 948 1-107 108-214 Zalutumumab_LightChain1 949 1-125 126-455 Zanolimumab_HO_HeavyChain 950 1-115 116-444 Zanolimumab_LO_LightChain 951 1-108 109-214 Zatuximab_HeavyChain1 952 1-119 120-448 Zatuximab_LightChain1 953 1-112 113-219

Accordingly, it is preferred that the at least one coding sequence of the RNA according to the present invention encodes a heavy chain variable region and/or a light chain variable region of an antibody, or an antigen-binding fragment or variant of a heavy chain variable region and/or a light chain variable region of an antibody. Preferably, the heavy chain variable region and/or the light chain variable region encoded by the at least one coding sequence comprises or consists of an amino acid sequence as described in Table 4 above.

Table 5 below shows the amino acid positions of the heavy chain and light chain CDRs in the heavy chain and light chain amino acid sequences of exemplified antibodies, which are preferably encoded by the RNA according to the present invention as described herein. Thereby, a CDR of, for example, “22-41” means that amino acids 22-41 of the respective amino acid sequence (“Protein SEQ ID NO”) form the respective CDR. The first column identifies whether the amino acid sequence (“Protein SEQ ID NO”) is of the heavy chain or of the light chain. Similarly to the variable regions/constant regions shown in Table 4, the skilled person can easily identify the heavy chain CDR's (CDRH1, CDRH2, CDRH3) and the light chain CDR's (CDRL1, CDRL2, CDRL3) of the exemplified antibodies based on the information in Table 5. Moreover, on basis of that information on amino acid sequence level, the skilled person can easily identify the corresponding RNA sequence fragments (i.e. the RNA sequences encoding the heavy chain/light chain CDR's, respectively), in particular by using the RNA sequences shown in Table 3 corresponding to the antibody of interest's amino acid sequence.

TABLE 5 CDRs of exemplified antibodies Name Protein SEQ ID NO CDR1 CDR2 CDR3 AAB-003_gamma1-Chain 1 22-41 94-113 Abagovomab_HeavyChain 2 22-41 51-60 94-113 Abagovomab_LightChain 3 22-41 29-38 86-105 Abciximab_HeavyChain 4 22-41 94-113 Abciximab_LightChain 5 22-41 48-57 86-105 Abituzumab_HeavyChain1 6 22-41 94-113 Abituzumab_LightChain1 7 22-41 48-57 86-105 Abrilumab_HeavyChain1 8 22-41 59-68 94-113 Abrilumab_LightChain1 9 22-41 48-57 86-105 Abrilumab_LightChain1_variant2 10 22-41 47-56 85-104 Actoxumab_HeavyChain1 11 22-41 94-113 Actoxumab_LightChain1 12 22-41 49-58 87-106 Adalimumab_HeavyChain 13 22-41 94-113 Adalimumab_LightChain 14 22-41 48-57 86-105 Aducanumab_HeavyChain1 15 22-41 94-113 Aducanumab_LightChain1 16 22-41 48-57 86-105 Afasevikumab_HeavyChain1 17 22-41 94-113 Afasevikumab_LightChain1 18 22-41 48-57 86-105 Aflibercept_Fusion_protein1 19 22-41 Afutuzuab_HeavyChain1 20 22-41 92-111 Afutuzuab_LightChain1 21 22-41 52-61 89-108 Afutuzumab_HeavyChain1 22 22-41 94-113 Afutuzumab_LightChain1 23 22-41 53-62 91-110 Alacizumab_pegol_HeavyChain1 24 22-41 94-113 Alacizumab_pegol_LightChain1 25 22-41 48-57 86-105 Alemtuzumab_HeavyChain 26 22-41 96-115 Alemtuzumab_HeavyChain_variant_Ibey_H 27 22-41 96-115 Alemtuzumab_HeavyChain_variant_Icel_H 28 22-41 96-115 Alemtuzumab_HeavyChain_variant_8005_H 29 22-41 96-115 Alemtuzumab_LightChain 30 22-41 48-57 86-105 Alemtuzumab_LightChain_variant_8005_L 31 22-41 48-57 86-105 Alirocumab_HeavyChain1 32 22-41 94-113 Alirocumab_LightChain1 33 22-41 54-63 92-111 ALX-0061_HeavyChain1 34 22-41 93-112 Amatuximab_HeavyChain1 35 22-41 Amatuximab_LightChain1 36 22-41 47-56 85-104 Anetumab_ravtansine_HeavyChain1 37 22-41 94-113 Anetumab_ravtansine_LightChain1 38 22-41 50-59 88-107 Anifrolumab_HeavyChain1 39 22-41 51-60 94-113 Anifrolumab_LightChain1 40 22-41 49-58 87-106 Anrukinzumab_HeavyChain1 41 22-41 93-112 Anrukinzumab_LightChain1 42 22-41 52-61 90-109 Apolizumab_HeavyChain1 43 22-41 93-112 Apolizumab_LightChain1 44 22-41 29-38 86-105 Apomab_HeavyChain 45 22-41 93-112 Apomab_LightChain 46 22-41 46-55 84-103 Aquaporumab_LightChain 47 22-41 87-106 Arcitumomab_99tc_HeavyChain 48 22-41 376-385 96-115 Arcitumomab_99tc_LightChain 49 22-41 47-56 85-104 Ascrinvacumab_HeavyChain1 50 22-41 53-62 95-114 Ascrinvacumab_LightChain1 51 22-41 49-58 87-106 Aselizub_HeavyChain1 52 22-41 91-110 Aselizub_HeavyChain2 53 22-41 91-110 Aselizuab_LightChain1 54 22-41 50-59 88-107 Atezolizumab_HeavyChain1 55 22-41 94-113 Atezolizumab_LightChain1 56 22-41 48-57 86-105 Atinumab_HeavyChain1 57 22-41 94-113 Atinumab_LightChain1 58 22-41 48-57 86-105 Atlizuab_HeavyChain1 59 22-41 92-111 Atlizuab_LightChain1 60 22-41 47-56 85-104 Aurograb_SingleChain 61 22-41 192-201 230-249  Avelumab_HeavyChain1 62 22-41 51-60 94-113 Avelumab_LightChain1 63 22-41 50-59 88-107 Bapineuzumab_HeavyChain1 64 22-41 94-113 Bapineuzumab_LightChain1 65 22-41 53-62 91-110 Basiliximab_HeavyChain 66 22-41 49-58 92-111 Basiliximab_LightChain 67 22-41 47-56 85-104 Bavituximab_HeavyChain 68 22-41 94-113 Bavituximab_LightChain 69 22-41 48-57 86-105 Bavituximab_LightChain_variant_8734_L 70 22-41 48-57 86-105 Begelomab_HeavyChain1 71 22-41 415-424 Begelomab_LightChain1 72 22-41 47-56 85-104 Benralizumab_HeavyChain1 73 22-41 Benralizumab_LightChain1 74 22-41 48-57 86-105 Betalutin_HeavyChain1 75 22-41 94-113 Betalutin_LightChain1 76 22-41 86-105 Bevacituzuab_HeavyChain1 77 22-41 92-111 Bevacituzuab_LightChain1 78 22-41 47-56 85-104 Bevacizumab_154-aspartic_acid_LightChain 79 22-41 48-57 86-105 Bevacizumab_154-substitution_deriv_LightChain 80 22-41 48-57 86-105 Bevacizumab_180-serine_HeavyChain 81 22-41 94-113 Bevacizumab_180-substitution_deriv_HeavyCahin 82 22-41 94-113 Bevacizumab_beta_HeavyChain1 83 22-41 94-113 Bevacizumab_beta_LightChain1 84 22-41 48-57 86-105 Bevacizumab_LcDomain 85 22-41 Bevacizumab_HeavyChain 86 22-41 94-113 Bevacizumab_HeavyChain_variant1 87 22-41 117-136  Bevacizumab_HeavyChain_V-Region 88 22-41 94-113 Bevacizumab_LightChain1 89 22-41 73-82 111-130  Bevacizumab_LightChain2 90 22-41 71-80 109-128  Bevacizumab_LightChain 91 22-41 48-57 86-105 Bevacizumab_LightChain_VJ-Region 92 22-41 48-57 86-105 Bevacizumab_LightChain_V-Region 93 22-41 48-57 86-105 Bevacizumab-rhuMAb-VEGF_HeavyChain_gamma1-Chain_VDJ-Region 94 22-41 94-113 Bevacizumab-rhuMAb-VEGF_LightChain_VJ-Region 95 22-41 48-57 86-105 Bevacizumab_gamma1-Chain 96 22-41 94-113 Bevacizumab_gamma1-Chain_CH3-Region_mutein 97 22-41 94-113 Bezlotoxumab_HeavyChain1 98 22-41 94-113 Bezlotoxumab_LightChain1 99 22-41 49-58 87-106 Bimagrumab_HeavyChain1 100 22-41 94-113 Bimagrumab_HeavyChain 101 22-41 94-113 Bimagrumab_LightChain1 102 22-41 50-59 88-107 Bimekizumab_HeavyChain1 103 22-41 107-116 94-113 Bimekizumab_LightChain1 104 22-41 48-57 86-105 Bleselumab_HeavyChain1 105 22-41 53-62 95-114 Bleselumab_LightChain1 106 22-41 49-57 86-105 Blinatumomab_HeavyChain1 107 22-41 52-61 349-368  Blinatumomab_SingleChain 108 22-41 52-61 349-368  Blinatumumab_SingleChain_variable_fragment_fusion_protein_(bite) 109 22-41 52-61 349-368  Blontuvetmab_HeavyChain 110 22-41 94-113 Blontuvetmab_LightChain 111 22-41 54-63 Blosozumab_HeavyChain1 112 22-41 94-113 Blosozumab_LightChain1 113 22-41 48-57 86-105 Bococizumab_HeavyChain1 114 22-41 94-113 Bococizumab_LightChain1 115 22-41 48-57 86-105 Brentuximab_vedotin_HeavyChain1 116 22-41 51-60 Brentuximab_vedotin_LightChain1 117 22-41 52-61 90-109 Briakinumab_HeavyChain1 118 22-41 94-113 Briakinumab_LightChain1 119 22-41 49-58 87-106 Brodalumab_HeavyChain1 120 22-41 94-113 Brodalumab_LightChain1 121 22-41 48-57 86-105 Brolucizumab_HeavyChain1 122 22-41 49-58 87-106 Brolucizumab_scfv_fragment 123 22-41 49-58 87-106 Brontictuzumab_HeavyChain1 124 22-41 94-113 Brontictuzumab_LightChain1 125 22-41 88-107 BTT-1023_HeavyChain1 126 22-41 94-113 BTT-1023_LightChain1 127 22-41 48-57 86-105 Burosumab_HeavyChain1 128 22-41 94-113 Burosumab_LightChain1 129 22-41 48-57 86-105 Canakinumab_HeavyChain1 130 22-41 94-113 Canakinumab_HeavyChain 131 22-41 94-113 Canakinumab_LightChain1 132 22-41 86-105 Canakinumab_LightChain 133 22-41 86-105 Canakinumab_LightChain_variant_8836_L 134 22-41 94-113 Cantuzumab_HeavyChain1 135 22-41 Cantuzumab_HeavyChain 136 22-41 Cantuzumab_LightChain1 137 22-41 53-62 91-110 Cantuzumab_mertansine_HeavyChain1 138 22-41 Cantuzumab_mertansine_LightChain1 139 22-41 53-62 91-110 Cantuzumab_ravtansine_HeavyChain1 140 22-41 Cantuzumab_ravtansine_LightChain1 141 22-41 53-62 91-110 Caplacizumab 142 22-41 94-113 Caplacizumab_HeavyChain1 143 22-41 94-113 Caplacizumab_HeavyChain1 144 22-41 94-113 Carlumab_HeavyChain1 145 22-41 102-111 94-113 Carlumab_LightChain1 146 22-41 49-58 87-106 Cergutuzumab_amunaleukin_HeavyChain1 147 22-41 94-113 Cergutuzumab_amunaleukin_HeavyChain2 148 22-41 94-113 Cergutuzumab_amunaleukin_LightChain1 149 22-41 48-57 86-105 Certolizumab_pegol_HeavyChain1 150 22-41 59-68 94-113 Certolizumab_pegol_HeavyChain 151 22-41 59-68 94-113 Certolizumab_pegol_LightChain1 152 22-41 48-57 86-105 Certolizumab_pegol_LightChain 153 22-41 48-57 86-105 Cetuximab_HeavyChain 154 22-41  92-101 93-112 Cetuximab_HeavyChain_variant 155 22-41  92-101 93-112 Cetuximab_LightChain 156 22-41 86-105 Cetuximab_LightChain_variant 157 22-41 86-105 Citatuzumab_bogatox_HeavyChain1 158 22-41 100-119  Citatuzumab_bogatox_LightChain1 159 22-41 53-62 91-110 Cixutumumab_HeavyChain1 160 22-41 94-113 Cixutumumab_LightChain1 161 22-41 47-56 85-104 Clazakizumab_HeavyChain1 162 22-41 51-60 93-112 Clazakizumab_LightChain1 163 22-41 48-57 86-105 Clivatuzumab_tetraxetan_HeavyChain1 164 22-41 94-113 Clivatuzumab_tetraxetan_LightChain1 165 22-41 49-58 Codrituzumab_HeavyChain1 166 22-41 94-113 Codrituzumab_LightChain1 167 22-41 53-62 91-110 Coltuximab_ravtansine_HeavyChain1 168 22-41 94-113 Coltuximab_ravtansine_LightChain1 169 22-41 47-56 85-104 Conatumumab_CV_HeavyChain 170 22-41 95-114 Conatumumab_CV_LightChain 171 22-41 49-58 87-106 Conatumumab_HeavyChain1 172 22-41 95-114 Conatumumab_HeavyChain 173 22-41 95-114 Conatumumab_LightChain1 174 22-41 49-58 87-106 Conatumumab_LightChain 175 22-41 49-58 87-106 Concizumab_HeavyChain1 176 22-41 94-113 Concizumab_LightChain1 177 22-41 53-62 91-110 Crenezumab_HeavyChain1 178 22-41 94-113 Crenezumab_LightChain1 179 22-41 53-62 91-110 Crotedumab_HeavyChain1 180 22-41 94-113 Crotedumab_HeavyChain2 181 22-41 94-113 Crotedumab_LightChain1 182 22-41 48-57 86-105 Crotedumab_LightChain2 183 22-41 48-57 86-105 Dacetuzumab_HeavyChain1 184 22-41 101-110 94-113 Dacetuzumab_LightChain1 185 22-41 53-62 Dacliximab_LightChain_VJ-Region 186 22-41 47-56 85-104 Dacliximab_gamma2-Chain_VDJ-Region 187 22-41 94-113 Daclizumab_HeavyChain 188 22-41 94-113 Daclizumab_LightChain 189 22-41 47-56 85-104 Dalotuzumab_HeavyChain1 190 22-41 Dalotuzumab_LightChain1 191 22-41 Dapirolizumab_pegol_HeavyChain1 192 22-41 93-112 Dapirolizumab_pegol_LightChain1 193 22-41 48-57 86-105 Daratumumab_HeavyChain1 194 22-41 Daratumumab_LightChain1 195 22-41 48-57 86-105 Dectrekumab_HeavyChain1 196 22-41 94-113 Dectrekumab_LightChain1 197 22-41 48-57 86-105 Demcizumab_HeavyChain1 198 22-41 94-113 Demcizumab_LightChain1 199 22-41 52-61 90-109 Denintuzumab_mafodotin_HeavyChain1 200 22-41 95-114 Denintuzumab_mafodotin_LightChain1 201 22-41 47-56 85-104 Denosumab_HeavyChain 202 22-41 94-113 Denosumab_LightChain 203 22-41 49-58 Depatuxizumab_HeavyChain1 204 22-41 94-113 Depatuxizumab_LightChain1 205 22-41 48-57 86-105 Depatuxizumab_mafodotin_HeavyChain1 206 22-41 94-113 Depatuxizumab_mafodotin_LightChain1 207 22-41 48-57 86-105 Dinutuximab_beta_HeavyChain1 208 22-41 94-113 Dinutuximab_beta_LightChain1 209 22-41 Dinutuximab_HeavyChain1 210 22-41 94-113 Dinutuximab_LightChain1 211 22-41 Dinutuximab_LightChain 212 22-41 Diridavumab_HeavyChain1 213 22-41 94-113 Diridavumab_LightChain1 214 22-41 49-58 87-106 Domagrozumab_HeavyChain1 215 22-41 94-113 Domagrozumab_HeavyChain 216 22-41 94-113 Domagrozumab_LightChain1 217 22-41 48-57 86-105 Drozituab_HeavyChain1 218 22-41 92-111 Drozituab_LightChain1 219 22-41 46-55 84-103 Drozitumab_HeavyChain1 220 22-41 94-113 Drozitumab_LightChain1 221 22-41 46-55 84-103 Duligotumab_HeavyChain1 222 22-41 94-113 Duligotumab_LightChain1 223 22-41 48-57 86-105 Duligotuzumab_HeavyChain1 224 22-41 94-113 Duligotuzumab_LightChain1 225 22-41 48-57 86-105 Dupilumab_HeavyChain1 226 22-41 94-113 Dupilumab_LightChain1 227 22-41 53-62 91-110 Durvalumab_HeavyChain1 228 22-41 94-113 Durvalumab_LightChain1 229 22-41 49-58 87-106 Dusigitumab_HeavyChain1 230 22-41 94-113 Dusigitumab_LightChain1 231 22-41 49-58 87-106 Ecromeximab_HeavyChain1 232 22-41 Ecromeximab_LightChain1 233 22-41 Eculizumab_HeavyChain1 234 22-41 93-112 Eculizumab_LightChain1 235 22-41 29-38 86-105 Efalizumab_HeavyChain 236 22-41 103-112 96-115 Efalizumab_LightChain 237 22-41 48-57 86-105 Efungumab_SingleChain_variable_fragment 238 22-41 185-194 96-115 Eldelumab_HeavyChain1 239 22-41  93-102 94-113 Eldelumab_LightChain1 240 22-41 49-58 87-106 Elgemtumab_HeavyChain1 241 22-41 94-113 Elgemtumab_LightChain1 242 22-41 48-57 86-105 Elotuzumab_HeavyChain1 243 22-41 94-113 Elotuzumab_LightChain1 244 22-41 48-57 86-105 Emactuzumab_HeavyChain1 245 22-41 93-112 Emactuzumab_LightChain1 246 22-41 48-57 86-105 Emibetuzumab_HeavyChain1 247 22-41 94-113 Emibetuzumab_LightChain1 248 22-41 32-41 87-106 Emicizumab_HeavyChain1 249 22-41 94-113 Emicizumab_HeavyChain2 250 22-41 59-68 Emicizumab_LightChain1 251 22-41 48-57 86-105 Enavatuzumab_HeavyChain1 252 22-41 96-115 Enavatuzumab_LightChain1 253 22-41 90-109 Enfortumab_HeavyChain 254 22-41 58-67 94-113 Enfortumab_LightChain 255 22-41 48-57 86-105 Enfortumab_vedotin_HeavyChain1 256 22-41 58-67 94-113 Enfortumab_vedotin_LightChain1 257 22-41 48-57 86-105 Enoblituzumab_HeavyChain 258 22-41 58-67 94-113 Enoblituzumab_LightChain 259 22-41 48-57 86-105 Enokizumab_HeavyChain1 260 22-41 94-113 Enokizumab_LightChain1 261 22-41 48-57 86-105 Enokizumab_LightChain 262 22-41 48-57 86-105 Enoticumab_HeavyChain1 263 22-41 94-113 Enoticumab_LightChain1 264 22-41 48-57 86-105 Ensituximab_HeavyChain1 265 22-41 93-112 Ensituximab_LightChain1 266 22-41 47-56 85-104 Ensituximab_SingleChain_variable_fragment 267 22-41 185-194 96-115 Entolimod_chain1 268 22-41 Epratuzumab_HeavyChain 269 22-41 Epratuzumab_LightChain 270 22-41 54-63 92-111 Eptacog_beta_HeavyChain1 271 22-41 Eptacog_beta_LightChain1 272 22-41 Erlizuab_HeavyChain1 273 22-41 89-108 Erlizuab_LightChain1 274 22-41 47-56 85-104 Etaracizumab_HeavyChain1 275 22-41 94-113 Etaracizumab_LightChain1 276 22-41 86-105 Etrolizuab_HeavyChain1 277 22-41 92-111 Etrolizuab_HeavyChain2 278 22-41 92-111 Etrolizuab_LightChain1 279 22-41 85-104 Etrolizumab_HeavyChain1 280 22-41 93-112 Etrolizumab_LightChain1 281 22-41 86-105 Evinacumab_HeavyChain1 282 22-41 Evinacumab_LightChain1 283 22-41 48-57 86-105 Evolocumab_HeavyChain1 284 22-41 94-113 Evolocumab_LightChain1 285 22-41 50-59 88-107 Exbivirumab_HeavyChain1 286 22-41 Exbivirumab_LightChain1 287 22-41 85-104 Farletuzumab_HeavyChain1 288 22-41 Farletuzumab_LightChain1 289 22-41 49-58 87-106 Fasinumab_HeavyChain1 290 22-41 59-68 94-113 Fasinumab_LightChain1 291 22-41 48-57 86-105 Fezakinumab_HeavyChain1 292 22-41 94-113 Fezakinumab_LightChain1 293 22-41 50-59 88-107 FG-3019_HeavyChain1 294 22-41 93-112 FG-3019_LightChain1 295 22-41 48-57 86-105 Fibatuzumab_HeavyChain1 296 22-41 51-60 94-113 Fibatuzumab_LightChain1 297 22-41 48-57 86-105 Ficlatuzumab_HeavyChain1 298 22-41 94-113 Ficlatuzumab_HeavyChain 299 22-41 93-112 Ficlatuzumab_LightChain1 300 22-41 48-57 Figitumumab_HeavyChain1 301 22-41 94-113 Figitumumab_LightChain1 302 22-41 48-57 86-105 Firivumab_HeavyChain1 303 22-41 94-113 Firivumab_LightChain1 304 22-41 85-94 Flanvotumab_HeavyChain1 305 22-41  93-102 94-113 Flanvotumab_LightChain1 306 22-41 48-57 86-105 Fletikumab_HeavyChain1 307 22-41 94-113 Fletikumab_LightChain1 308 22-41 48-57 86-105 Fontolizumab_HeavyChain1 309 22-41 94-113 Fontolizumab_LightChain1 310 22-41 48-57 86-105 Foralumab_HeavyChain1 311 22-41 94-113 Foralumab_LightChain1 312 22-41 48-57 86-105 Foravirumab_HeavyChain1 313 22-41 94-113 Foravirumab_HeavyChain 314 22-41 94-113 Foravirumab_LightChain1 315 22-41 48-57 86-105 Fresolimumab_HeavyChain1 316 22-41 94-113 Fresolimumab_LightChain1 317 22-41 49-58 87-106 Fulranumab_HeavyChain1 318 22-41 94-113 Fulranumab_LightChain1 319 22-41 48-57 86-105 Futuximab_HeavyChain1 320 22-41 51-60 94-113 Futuximab_LightChain1 321 22-41 48-57 Galcanezumab_HeavyChain1 322 22-41 51-60 94-113 Galcanezumab_LightChain1 323 22-41 48-57 86-105 Galiximab_HeavyChain1 324 22-41 95-114 Galiximab_LightChain1 325 22-41 49-58 87-106 Ganitumab_HeavyChain1 326 22-41 52-61 94-113 Ganitumab_LightChain1 327 22-41 53-62 91-110 Gantenerumab_HeavyChain1 328 22-41 94-113 Gantenerumab_LightChain1 329 22-41 49-58 87-106 Gemtuzumab_HeavyChain1 330 22-41 94-113 Gemtuzumab_HeavyChain2 331 22-41 102-111 Gemtuzumab_LightChain2 332 22-41 86-105 Gemtuzumab_ozogamicin_LightChain1 333 22-41 47-56 85-104 Gevokizumab_HeavyChain1 334 22-41 Gevokizumab_LightChain1 335 22-41 48-57 Girentuximab_HeavyChain1 336 22-41 Girentuximab_LightChain1 337 22-41 48-57 Glembatumumab_HeavyChain1 338 22-41 53-62 95-114 Glembatumumab_LightChain1 339 22-41 48-57 86-105 Goilixiab_HeavyChain1 340 22-41 94-113 Goilixiab_LightChain1 341 22-41 47-56 85-104 Guselkumab_HeavyChain1 342 22-41 94-113 Guselkumab_LightChain1 343 22-41 50-59 88-107 HuMab-001_HeavyChain_VDJ-Region 344 22-41 93-112 HuMab-001_LightChain_VJ-Region 345 22-41 86-105 HuMab-005_HeavyChain_gamma-Chain_VDJ-Region 346 22-41 51-60 94-113 HuMab-005_LightChain_VJ-Region 347 22-41 49-58 87-106 HuMab-006_HeavyChain_VDJ-Region 348 22-41 94-113 HuMab-006_LightChain_VJ-Region 349 22-41 48-57 86-105 HuMab-019_HeavyChain_VDJ-Region 350 22-41 93-112 HuMab-021_HeavyChain_VDJ-Region 351 22-41 93-112 HuMab-021_LightChain_VJ-Region 352 22-41 48-57 86-105 HuMab-025_HeavyChain_VDJ-Region 353 22-41 93-112 HuMab-025_LightChain_VJ-Region 354 22-41 48-57 86-105 HuMab-027_HeavyChain_VDJ-Region 355 22-41 93-112 HuMab-032_HeavyChain_VDJ-Region 356 22-41 104-113 93-112 HuMab-032_LightChain_VJ-Region 357 22-41 48-57 86-105 HuMab-033_HeavyChain_VDJ-Region 358 22-41 94-113 HuMab-035_HeavyChain_VDJ-Region 359 22-41 24-33 93-112 HuMab-036_HeavyChain_VDJ-Region 360 22-41 93-112 HuMab-036_LightChain_VJ-Region 361 22-41 48-57 86-105 HuMab-041_HeavyChain_VDJ-Region 362 22-41 51-60 94-113 HuMab-044_HeavyChain_VDJ-Region 363 22-41 94-113 HuMab-049_HeavyChain_VDJ-Region 364 22-41 94-113 HuMab-049_LightChain_VJ-Region 365 22-41 48-57 86-105 HuMab-050_HeavyChain_VDJ-Region 366 22-41 94-113 HuMab-050_LightChain_VJ-Region 367 22-41 48-57 86-105 HuMab-054_HeavyChain_VDJ-Region 368 22-41 93-112 HuMab-054_LightChain_VJ-Region 369 22-41 48-57 86-105 HuMab-055_HeavyChain_VDJ-Region 370 22-41 94-113 HuMab-059_HeavyChain_VDJ-Region 371 22-41 94-113 HuMab-059_LightChain_VJ-Region 372 22-41 49-58 87-106 HuMab-060_HeavyChain_VDJ-Region 373 22-41 51-60 94-113 HuMab-060_LightChain_VJ-Region 374 22-41 49-58 87-106 HuMab-067_HeavyChain_VDJ-Region 375 22-41 51-60 94-113 HuMab-072_HeavyChain_VDJ-Region 376 22-41 51-60 94-113 HuMab-072_LightChain_VJ-Region 377 22-41 49-58 87-106 HuMab-084_HeavyChain_VDJ-Region 378 22-41 94-113 HuMab-084_LightChain_VJ-Region 379 22-41 48-57 86-105 HuMab-091_HeavyChain_VDJ-Region 380 22-41 51-60 93-112 HuMab-091_LightChain_VJ-Region 381 22-41 48-57 86-105 HuMab-093_HeavyChain_VDJ-Region 382 22-41 51-60 94-113 HuMab-098_HeavyChain_VDJ-Region 383 22-41 94-113 HuMab-098_LightChain_VJ-Region 384 22-41 48-57 86-105 HuMab-100_HeavyChain_VDJ-Region 385 22-41 94-113 HuMab-106_HeavyChain_VDJ-Region 386 22-41 51-60 94-113 HuMab-106_LightChain_VJ-Region 387 22-41 49-58 87-106 HuMab_10F8_HeavyChain_V-Region 388 22-41 94-113 HuMab_10F8_HeavyChain_V-Region_Precursor 389 22-41 113-132  HuMab_10F8_LightChain_V-Region 390 22-41 49-58 87-106 HuMab_10F8_LightChain_V-Region_Precursor 391 22-41 69-78 107-126  HuMab-111_HeavyChain_VDJ-Region 392 22-41 94-113 HuMab-111_LightChain_VJ-Region 393 22-41 49-58 87-106 HuMab-123_HeavyChain_VDJ-Region 394 22-41 59-68 94-113 HuMab-123_LightChain_VJ-Region 395 22-41 48-57 86-105 HuMab-124_HeavyChain_VDJ-Region 396 22-41 59-68 94-113 HuMab-125_HeavyChain_VDJ-Region 397 22-41 94-113 HuMab-125_LightChain_VJ-Region 398 22-41 48-57 86-105 HuMab-127_HeavyChain_VDJ-Region 399 22-41 31-40 94-113 HuMab-127_LightChain_VJ-Region 400 22-41 48-57 86-105 HuMab-129_HeavyChain_VDJ-Region 401 22-41 94-113 HuMab-129_LightChain_VJ-Region 402 22-41 48-57 86-105 HuMab-132_HeavyChain_VDJ-Region 403 22-41 94-113 HuMab-132_LightChain_VJ-Region 404 22-41 48-57 86-105 HuMab-143_HeavyChain_VDJ-Region 405 22-41 93-112 HuMab-143_LightChain_VJ-Region 406 22-41 48-57 86-105 HuMab-150_HeavyChain_VDJ-Region 407 22-41 51-60 94-113 HuMab-150_LightChain_VJ-Region 408 22-41 49-58 87-106 HuMab-152_HeavyChain_VDJ-Region 409 22-41 94-113 HuMab-152_LightChain_VJ-Region 410 22-41 48-57 86-105 HuMab-153_HeavyChain_VDJ-Region 411 22-41 94-113 HuMab-153_LightChain_VJ-Region 412 22-41 48-57 86-105 HuMab-159_HeavyChain_VDJ-Region 413 22-41 51-60 94-113 HuMab-159_LightChain_VJ-Region 414 22-41 48-57 86-105 HuMab-160_HeavyChain_VDJ-Region 415 22-41 HuMab-160_LightChain_VJ-Region 416 22-41 48-57 86-105 HuMab-162_HeavyChain_VDJ-Region 417 22-41 94-113 HuMab-162_LightChain_VJ-Region 418 22-41 48-57 86-105 HuMab-163_HeavyChain_VDJ-Region 419 22-41 51-60 94-113 HuMab-163_LightChain_VJ-Region 420 22-41 49-58 87-106 HuMab-166_HeavyChain_VDJ-Region 421 22-41 94-113 HuMab-166_LightChain_VJ-Region 422 22-41 48-57 86-105 HuMab-167_HeavyChain_VDJ-Region 423 22-41 94-113 HuMab-169_HeavyChain_VDJ-Region 424 22-41 59-68 94-113 HuMab-169_LightChain_VJ-Region 425 22-41 48-57 86-105 HuMab-708_HeavyChain_VH-Region 426 22-41 94-113 HuMab-708_HeavyChain_V-Region 427 22-41 94-113 HuMab-708_LightChain_VL-Region 428 22-41 48-57 86-105 HuMab-708_LightChain_V-Region 429 22-41 48-57 86-105 huMab-anti-MSP10.1_LightChain_VJ-Region 430 22-41 49-58 87-106 huMab-anti-MSP10.2_LightChain_VJ-Region 431 22-41 49-58 87-106 HUMAB-Clone_18_VJ-Region 432 22-41 48-57 86-105 HUMAB-Clone_22_VJ-Region 433 22-41 48-57 86-105 HuMab-L612_μChain_VDJ-Region_Precursor 434 22-41 113-132  HuMab_LC5002-002_LightChain_V-Region 435 22-41 48-57 86-105 HuMab_LC5002-002_gamma1-Chain_V-Region 436 22-41 31-40 94-113 HuMab_LC5002-003_LightChain_V-Region 437 22-41 48-57 86-105 HuMab_LC5002-003_gamma1-Chain_V-Region 438 22-41 31-40 94-113 HuMab_LC5002-005_LightChain_V-Region 439 22-41 48-57 86-105 HuMab_LC5002-005_gamma1-Chain_V-Region 440 22-41 103-112 94-113 HuMab_LC5002-007_LightChain_V-Region 441 22-41 49-58 87-106 HuMab_LC5002-007_gamma1-Chain_V-Region 442 22-41 94-113 HuMab_LC5002-018_gamma1-Chain_V-Region 443 22-41 31-40 94-113 Ibalizumab_HeavyChain1 444 22-41 94-113 Ibalizumab_LightChain1 445 22-41 54-63 92-111 Ibritumomab_tiuxetan_HeavyChain 446 22-41 51-60 Ibritumomab_tiuxetan_LightChain 447 22-41 47-56 85-104 Icrucumab_HeavyChain1 448 22-41 94-113 Icrucumab_LightChain1 449 22-41 49-58 87-106 Idarucizumab_HeavyChain1 450 22-41 93-112 Idarucizumab_LightChain1 451 22-41 53-62 91-110 Igatuzuab_HeavyChain1 452 22-41 92-111 Igatuzuab_LightChain1 453 22-41 47-56 85-104 IGF-IR_HUMAB-1A_HeavyChain 454 22-41 93-112 IGF-IR_HUMAB-23_HeavyChain 455 22-41 IGF-IR_HUMAB-23_LightChain 456 22-41 48-57 86-105 IGF-IR_HUMAB-8_HeavyChain 457 22-41 93-112 IGF-IR_HUMAB-8_LightChain 458 22-41 48-57 86-105 ImAb1_LightChain 459 22-41 70-79 108-127  ImAb1_gamma1-Chain 460 22-41 112-131  Imalumab_HeavyChain1 461 22-41 31-40 94-113 Imalumab_LightChain1 462 22-41 86-105 Imgatuzumab_HeavyChain1 463 22-41 94-113 Imgatuzumab_LightChain1 464 22-41 48-57 86-105 Inclacumab_HeavyChain1 465 22-41 57-66 93-112 Inclacumab_LightChain1 466 22-41 48-57 86-105 Indatuximab_ravtansine_HeavyChain1 467 22-41 59-68 94-113 Indatuximab_ravtansine_LightChain1 468 22-41 48-57 86-105 Indusatumab_vedotin_HeavyChain1 469 22-41 93-112 Indusatumab_vedotin_LightChain1 470 22-41 48-57 86-105 Inebilizumab_HeavyChain1 471 22-41 51-60 94-113 Inebilizumab_LightChain1 472 22-41 90-109 Insulin_peglispro_Fragment1 473 22-30 Insulin_peglispro_Fragment2 474 22-21 Interferon_beta-Ib_chain1 475 22-41 58-67 Intetumumab_HeavyChain1 476 22-41 94-113 Intetumumab_LightChain1 477 22-41 48-57 86-105 Iodine_(I241)_Girentuximab_HeavyChain1 478 22-41 Iodine_(I241)_Girentuximab_LightChain1 479 22-41 48-57 Iodine_(I311)_Derlotuxiab_biotin_HeavyChain1 480 22-41 91-110 Iodine_(I311)_Derlotuxiab_biotin_LightChain1 481 22-41 47-56 85-104 Iodine_(I311)_Derlotuximab_biotin_HeavyChain1 482 22-41 93-112 Iodine_(I311)_Derlotuximab_biotin_LightChain1 483 22-41 49-58 87-106 Ipilimumab_HeavyChain 484 22-41  93-102 94-113 Ipilimumab_LightChain 485 22-41 49-58 87-106 Iratumumab_HeavyChain1 486 22-41 Iratumumab_LightChain1 487 22-41 48-57 86-105 Isatuximab_HeavyChain1 488 22-41 51-60 94-113 Isatuximab_LightChain1 489 22-41 48-57 86-105 Itolizumab_HeavyChain1 490 22-41 58-67 94-113 Itolizumab_LightChain1 491 22-41 48-57 86-105 Ixekizumab_HeavyChain1 492 22-41 94-113 Ixekizumab_LightChain1 493 22-41 53-62 91-110 Labetuzumab_govitecan_HeavyChain1 494 22-41 Labetuzumab_govitecan_LightChain1 495 22-41 48-57 86-105 Lambrolizumab_HeavyChain1 496 22-41 94-113 Lambrolizumab_LightChain1 497 22-41 52-61 90-109 Lampalizumab_HeavyChain1 498 22-41 94-113 Lampalizumab_LightChain1 499 22-41 86-105 Lanadelumab_HeavyChain1 500 22-41 51-60 94-113 Lanadelumab_LightChain1 501 22-41 48-57 86-105 Landogrozumab_HeavyChain1 502 22-41 94-113 Landogrozumab_LightChain1 503 22-41 49-58 87-106 Laprituximab_emtansine_HeavyChain1 504 22-41 51-60 94-113 Laprituximab_emtansine_LightChain1 505 22-41 86-105 Lealesoab_HeavyChain1 506 22-41 Lealesoab_LightChain1 507 22-41 53-62 91-110 Lebrikizumab_HeavyChain1 508 22-41 93-112 Lebrikizumab_LightChain1 509 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22-41 52-61 89-108 PankoMab_HeavyChain_VDJ-Region 665 22-41  95-104 96-115 PankoMab_LightChain_VJ-Region 666 22-41 53-62 91-110 Panobacumab_HeavyChain1 667 22-41 93-112 Panobacumab_LightChain1 668 22-41 53-62 91-110 Panobacumab_LightChain2 669 22-41 Parsatuzumab_HeavyChain1 670 22-41 94-113 Parsatuzumab_LightChain1 671 22-41 53-62 91-110 Pascolizumab_HeavyChain1 672 22-41 53-62 95-114 Pascolizumab_LightChain1 673 22-41 52-61 90-109 Pasotuxizumab_HeavyChain1 674 22-41 184-193 94-113 Pasotuxizumab_SingleChain 675 22-41 184-193 94-113 Pateclizumab_HeavyChain1 676 22-41 94-113 Pateclizumab_LightChain1 677 22-41 48-57 86-105 Patritumab_HeavyChain1 678 22-41 93-112 Patritumab_hinge-CH2—CH3 679 22-41 Patritumab_LightChain1 680 22-41 54-63 92-111 Pembrolizumab_HeavyChain1 681 22-41 94-113 Pembrolizumab_LightChain1 682 22-41 52-61 90-109 Perakizumab_HeavyChain1 683 22-41 94-113 Perakizumab_LightChain1 684 22-41 86-105 Pertuzuab_HeavyChain1 685 22-41 58-67 92-111 Pertuzuab_LightChain1 686 22-41 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51-60 94-113 rhuMab_HER2_gamma1-Chain_V-Region 751 22-41 51-60 94-113 rhuMAb-VEGF_HeavyChain1 752 22-41 94-113 rhuMAb-VEGF_LightChain1 753 22-41 48-57 86-105 rhuMAb-VEGF_LightChain 754 22-41 48-57 86-105 rhuMAb-VEGF_LightChain_VG-Region 755 22-41 48-57 86-105 rhuMAb-VEGF_gamma1-Chain 756 22-41 94-113 rhuMAb-VEGF_gamma1-Chain_VDG-Region 757 22-41 94-113 Rilotumumab_HeavyChain1 758 22-41 31-40 93-112 Rilotumumab_LightChain1 759 22-41 48-57 86-105 Rilotumumab_scFv-CH_chain 760 22-41 177-186 94-113 Rinucumab_HeavyChain1 761 22-41 53-62 95-114 Rinucumab_HeavyChain 762 22-41 53-62 95-114 Rinucumab_LightChain1 763 22-41 32-41 87-106 Risankizumab_HeavyChain1 764 22-41 51-60 94-113 Risankizumab_LightChain1 765 22-41 48-57 Rituximab_HeavyChain 766 22-41 51-60 94-113 Rituximab_HeavyChain_variant 767 22-41 51-60 94-113 Rituximab_LightChain 768 22-41 47-56 85-104 Rivabazumab_pegol_HeavyChain1 769 22-41 103-112 94-113 Rivabazumab_pegol_LightChain1 770 22-41 48-57 86-105 Robatumumab_HeavyChain1 771 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Solitomab_SingleChain 816 22-41 54-63 92-111 Sonepcizumab_LightChain_Precursor 817 22-41 106-125  Sonepcizumab_gamma1-Chain_Precursor 818 22-41 Stamulumab_HeavyChain1 819 22-41 93-112 Stamulumab_LightChain1 820 22-41 47-56 85-104 Suptavumab_HeavyChain1 821 22-41 94-113 Suptavumab_LightChain1 822 22-41 48-57 86-105 Suvizumab_HeavyChain1 823 22-41 51-60 94-113 Suvizumab_LightChain1 824 22-41 54-63 92-111 Tabalumab_HeavyChain1 825 22-41 93-112 Tabalumab_LightChain1 826 22-41 48-57 86-105 Tacatuzuab_HeavyChain1 827 22-41 Tacatuzuab_LightChain1 828 22-41 85-104 Tadocizumab_fab_fragment_HeavyChain 829 22-41 51-60 Tadocizumab_fab_fragment_LightChain 830 22-41 48-57 Talizumab_HeavyChain1 831 22-41 94-113 Talizumab_LightChain1 832 22-41 86-105 Tamtuvetmab_HeavyChain1 833 22-41 96-115 Tamtuvetmab_LightChain1 834 22-41 48-57 Tanezumab_HeavyChain 835 22-41 93-112 Tanezumab_LightChain 836 22-41 48-57 86-105 Tarextumab_HeavyChain1 837 22-41 94-113 Tarextumab_LightChain1 838 22-41 49-58 87-106 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anti-IsdB_5D1X_Chain-B 1116 22-41 94-113 anti-IsdB_5D1X_Chain-C 1117 22-41 103-122  anti-IsdB_5D1X_Chain-D 1118 22-41 49-58 87-106 anti-IsdB_5D1X_Chain-E 1119 22-41 anti-IsdB_5D1Z_Chain-B 1120 22-41 95-114 anti-IsdB_5D1Z_Chain-C 1121 22-41 48-57 86-105 anti-IsdB_5D1Z_Chain-D 1122 22-41 53-62 95-114 anti-IsdB_5D1Z_Chain-F 1123 22-41 53-62 95-114 anti-IsdB_5D1Z_Chain-G 1124 22-41 95-114 anti-IsdB_5D1Z_HeavyChain 1125 22-41 48-57 86-105 anti-IsdB_5D1Z_Chain-1 1126 22-41 148-157 anti-HIV_b12_LightChain 1127 22-41 87-106 anti-HIV_b12_HeavyChain 1128 22-41 94-113 anti-HIV_2G12_LightChain 1129 22-41 47-56 anti-HIV_2G12_HeavyChain 1130 22-41  93-102 94-113 anti-HIV_4E10_LightChain 1131 22-41 49-58 87-106 anti-HIV_4E10_HeavyChain 1132 22-41 94-113 anti-HIV_VRC01_LightChain 1133 22-41 46-55 84-103 anti-HIV_VRC01_HeavyChain 1134 22-41 anti-HIV_PG9_LightChain 1135 22-41 50-59 88-107 anti-HIV_PG9_HeavyChain 1136 22-41 anti-HIV_VRC07_LightChain 1137 22-41 48-55 84-103 anti-HIV_VRC07_HeavyChain 1138 22-41 anti-HIV_3BNC117_LightChain 1139 22-41 44-53 anti-HIV_3BNC117_HeavyChain 1140 22-41 anti-HIV_10-1074_LightChain 1141 22-41 43-52 84-103 anti-HIV_10-1074_HeavyChain 1142 22-41 104-113 93-112 anti-HIV_PGT121_LightChain 1143 22-41 40-49 81-100 anti-HIV_PGT121_HeavyChain 1144 22-41 104-113 93-112 anti-HIV_PGDM1400_LightChain 1145 22-41 53-62 91-110 anti-HIV_PGDM1400_HeavyChain 1146 22-41 94-113 anti-HIV_N6_LightChain 1147 22-41 86-105 anti-HIV_N6_HeavyChain 1148 22-41 94-113 anti-HIV_N6_GChain 1149 22-41 anti-HIV_10E8_LightChain 1150 22-41 85-104 anti-HIV_10E8_HeavyChain 1151 22-41 anti-HIV_12A12_LightChain 1152 22-41 anti-HIV_12A12_HeavyChain 1153 22-41 74-83 anti-HIV_12A21_LightChain 1154 22-41 anti-HIV_12A21_HeavyChain 1155 22-41 74-83 94-113 anti-HIV_35022_LightChain 1156 22-41 50-59 88-107 anti-HIV_35022_HeavyChain 1157 22-41 anti-HIV_38C176_LightChain 1158 22-41 50-59 88-107 anti-HIV_38C176_HeavyChain 1159 22-41 anti-HIV_38NC55_LightChain 1160 22-41 83-102 anti-HIV_38NC55_HeavyChain 1161 22-41 34-43 anti-HIV_38NC60_LightChain 1162 22-41 44-53 anti-HIV_38NC60_HeavyChain 1163 22-41  97-106 anti-HIV_38NC60_HeavyChain 1164 22-41  97-106 anti-HIV_447-52D_LightChain 1165 22-41 49-58 anti-HIV_447-52D_HeavyChain 1166 22-41 anti-HIV_447-52D_LightChain 1167 22-41 49-58 anti-HIV_447-52D_HeavyChain 1168 22-41 anti-HIV_5H/11-BMV-D5_LightChain 1169 22-41 29-38 86-105 anti-HIV_5H/11-BMV-D5_HeavyChain 1170 22-41  93-102 94-113 anti-HIV_5H/11-BMV-D5_A-Chain 1171 22-41 anti-HIV_8ANC195_LightChain 1172 22-41 49-58 anti-HIV_8ANC195_HeavyChain 1173 22-41 anti-HIV_CAP256-VRC26.01_LightChain 1174 22-41 49-58 87-106 anti-HIV_CAP256-VRC26.01_HeavyChain 1175 22-41 94-113 anti-HIV_CAP256-VRC26.02_LightChain 1176 22-41 49-58 87-106 anti-HIV_CAP256-VRC26.02_HeavyChain 1177 22-41 anti-HIV_CAP256-VRC26.03_LightChain 1178 22-41 49-58 87-106 anti-HIV_CAP256-VRC26.03_HeavyChain 1179 22-41 94-113 anti-HIV_CAP256-VRC26.04_LightChain 1180 22-41 49-58 87-106 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anti-HIV_PGT122_LightChain 1220 22-41 40-49 81-100 anti-HIV_PGT122_HeavyChain 1221 22-41  92-101 93-112 anti-HIV_PGT123_LightChain 1222 22-41 40-49 81-100 anti-HIV_PGT123_HeavyChain 1223 22-41 104-113 anti-HIV_PGT125_LightChain 1224 22-41 83-102 anti-HIV_PGT125_HeavyChain 1225 22-41 101-120  anti-HIV_PGT126_LightChain 1226 22-41 45-54 83-102 anti-HIV_PGT126_HeavyChain 1227 22-41 100-109 101-120  anti-HIV_PGT127_LightChain 1228 22-41 45-54 83-102 anti-HIV_PGT127_HeavyChain 1229 22-41 101-120  anti-HIV_PGT128_LightChain 1230 22-41 45-54 83-102 anti-HIV_PGT128_HeavyChain 1231 22-41 101-120  anti-HIV_PGT130_LightChain 1232 22-41 anti-HIV_PGT130_HeavyChain 1233 22-41 73-82 anti-HIV_PGT131_LightChain 1234 22-41 anti-HIV_PGT131_HeavyChain 1235 22-41 anti-HIV_PGT135_LightChain 1236 22-41 86-105 anti-HIV_PGT135_HeavyChain 1237 22-41 anti-HIV_PGT136_LightChain 1238 22-41 anti-HIV_PGT136_HeavyChain 1239 22-41 101-120  anti-HIV_PGT137_LightChain 1240 22-41 86-105 anti-HIV_PGT137_HeavyChain 1241 22-41 100-119  anti-HIV_PGT141_LightChain 1242 22-41 90-99 91-110 anti-HIV_PGT141_HeavyChain 1243 22-41  93-102 94-113 anti-HIV_PGT142_LightChain 1244 22-41 90-99 91-110 anti-HIV_PGT142_HeavyChain 1245 22-41  93-102 94-113 anti-HIV_PGT143_LightChain 1245 22-41 90-99 91-110 anti-HIV_PGT143_HeavyChain 1247 22-41  93-102 94-113 anti-HIV_PGT144_LightChain 1248 22-41 90-99 91-110 anti-HIV_PGT144_HeavyChain 1249 22-41  93-102 94-113 anti-HIV_PGT145_LightChain 1250 22-41 91-110 anti-HIV_PGT145_HeavyChain 1251 22-41  93-102 94-113 anti-HIV_PGT151_LightChain 1252 22-41 91-110 anti-HIV_PGT151_HeavyChain 1253 22-41 anti-HIV_PGT152_LightChain 1254 22-41 91-110 anti-HIV_PGT152_HeavyChain 1255 22-41 anti-HIV_VRC-CH30_LightChain 1255 22-41 anti-HIV_VRC-CH30_HeavyChain 1257 22-41 103-122  anti-HIV_VRC-CH31_LightChain 1258 22-41 anti-HIV_VRC-CH31_HeavyChain 1259 22-41 103-122  anti-HIV_VRC-CH32_LightChain 1260 22-41 anti-HIV_VRC-CH32_HeavyChain 1261 22-41 103-122  anti-HIV_VRC-CH33_LightChain 1262 22-41 anti-HIV_VRC-CH33_HeavyChain 1263 22-41 103-122  anti-HIV_VRC-CH34_LightChain 1264 22-41 anti-HIV_VRC-CH34_HeavyChain 1265 22-41 103-122  anti-HIV_VRC-PG04_LightChain 1266 22-41 84-102 anti-HIV_VRC-PG04_HeavyChain 1267 22-41 anti-HIV_VRC-PG04b_LightChain 1268 22-41 84-101 anti-HIV_VRC-PG04b_HeavyChain 1269 22-41 anti-HIV_VRC-PG20_LightChain 1270 22-41 anti-HIV_VRC-PG20_HeavyChain 1271 22-41 anti-HIV_VRC-PG20_G-Chain 1272 22-41 anti-HIV_VRC02_LightChain 1273 22-41 46-55 84-103 anti-HIV_VRC02_HeavyChain 1274 22-41 94-113 anti-HIV_VRC03_LightChain 1275 22-41 47-56 85-103 anti-HIV_VRC03_HeavyChain 1276 22-41 anti-HIV_VRC23_LightChain 1277 22-41 48-57 86-105 anti-HIV_VRC23_HeavyChain 1278 22-41  93-102 94-113 anti-HIV_VRC23_G-Chain 1279 22-41 anti-HIV_5CCK_LightChain 1280 22-41 50-59 88-107 anti-HIV_5CCK_HeavyChain 1281 22-41 anti-HIV_5AWN_LightChain 1282 22-41 50-59 88-107 anti-HIV_5AWN_HeavyChain 1283 22-41 anti-HIV_3QEG_LightChain 1284 22-41 49-58 87-106 anti-HIV_3QEG_HeavyChain 1285 22-41 94-113 anti-HIV_1NOX_K-Chain 1286 22-41 94-113 anti-HIV_1NOX_M-Chain 1287 22-41 87-106 anti-HIV_3QEH_HeavyChain 1288 22-41 53-62 91-110 anti-HIV_3QEH_G-Chain 1289 22-41  93-102 94-113 anti-HIV_2B1H_HeavyChain 1290 22-41 94-113 anti-HIV_2B1H_LightChain 1291 22-41 49-58 87-106 anti-HIV_3TNM_B-Chain 1292 22-41 88-107 anti-HIV_3TNM_A-Chain 1293 22-41 95-114 anti-HIV_3UJJ_HeavyChain 1294 22-41 51-60 94-113 anti-HIV_3UJJ_LightChain 1295 22-41 47-56 85-104 anti-HIV_3UJ1_HeavyChain 1296 22-41 94-113 anti-HIV_3UJ1_LightChain 1297 22-41 47-56 85-104 anti-HIV_2QSC_HeavyChain 1298 22-41 94-113 anti-HIV_2QSC_LightChain 1299 22-41 48-57 anti-HIV_3MLZ_HeavyChain 1300 22-41 51-60 93-112 anti-HIV_3MLZ_LightChain 1301 22-41 49-58 87-106 anti-HIV_3MLX_I-Chain 1302 22-41 51-60 93-112 anti-HIV_3MLX_M-Chain 1303 22-41 48-57 86-105 anti-HIV_3MLW_I-Chain 1304 22-41 51-60 94-113 anti-HIV_3MLW_M-Chain 1305 22-41 87-108 anti-HIV_3MLV_N-Chain 1306 22-41 51-60 anti-HIV_3MLV_M-Chain 1307 22-41 85-104 anti-HIV_3MLU_LightChain 1308 22-41 84-103 anti-HIV_3MLT_G-Chain 1309 22-41 85-104 anti-HIV_3G01_HeavyChain 1310 22-41 93-112 anti-HIV_3G01_LightChain 1311 22-41 47-56 B5-104 anti-HIV_4XCY_J-Chain 1312 22-41 94-113 anti-HIV_4XCY_K-Chain 1313 22-41 49-5B 87-108 anti-HIV_4YBL_C-Chain 1314 22-41 86-105 anti-HIV_4YBL_B-Chain 1315 22-41 95-114 anti-HIV_4R4N_X-Chain 1316 22-41 48-57 86-105 anti-HIV_4R4B_F-Chain 1317 22-41 anti-HIV_3JUY_D-Chain 1318 22-41 94-113 anti-HIV_4KG5_HeavyChain 1319 22-41 92-111 anti-HIV_4KG5_LightChain 1320 22-41 51-60 89-108 anti-HIV-1_LightChain 1321 22-41 48-57 86-103 anti-HIV-1_LightChain 1322 22-41 49-58 87-104 anti-HIV-1_LightChain 1323 22-41 anti-HIV-1_LightChain 1324 22-41 49-5B 87-104 anti-HIV-1_LightChain 1325 22-41 87-104 anti-HIV-1_LightChain 1326 22-41 49-58 87-104 anti-HIV-1_HeavyChain 1327 22-41 74-83 94-113 anti-HIV-1_HeavyChain 1328 22-41 74-83 94-113 anti-HIV-1_HeavyChain 1329 22-41 anti-HIV-1_HeavyChain 1330 22-41 96-115 anti-HIV-1_HeavyChain 1331 22-41 94-113 anti-HIV-1_HeavyChain 1332 22-41 94-113 anti-HIV-1_HeavyChain 1333 22-41 anti-HIV-1_HeavyChain 1334 22-41 94-113 anti-HIV-1_HeavyChain 1335 22-41 93-112 anti-HIV-1_HeavyChain 1336 22-41 94-113 anti-HIV-1_LightChain 1337 22-41 49-58 87-106 anti-HIV-1_LightChain 1338 22-41 49-58 87-106 anti-HIV-1_LightChain 1339 22-41 49-58 87-106 anti-HIV-1_LightChain 1340 22-41 49-58 87-106 anti-HIV-1_LightChain 1341 22-41 53-62 91-110 anti-HIV-1_LightChain 1342 22-41 48-57 86-105 anti-HIV-1_LightChain 1343 22-41 89-108 anti-HIV-1_LightChain 1344 22-41 89-108 anti-HIV-1_HeavyChain 1345 22-41 99-118 anti-HIV-1_HeavyChain 1346 22-41 99-118 anti-HIV-1_HeavyChain 1347 22-41 99-118 anti-HIV-1_HeavyChain 1348 22-41 97-118 anti-HIV-1_HeavyChain 1349 22-41 24-33 93-112 anti-HIV-1_HeavyChain 1350 22-41 97-116 anti-HIV-1_HeavyChain 1351 22-41 anti-HIV-1_HeavyChain 1352 22-41 94-113 anti-HIV_V3_HeavyChain 1353 22-41 51-60 94-113 anti-HIV_V3_HeavyChain 1354 22-41 51-60 94-113 anti-HIV_V3_HeavyChain 1355 22-41 94-113 anti-HIV_V3_HeavyChain 1356 22-41 93-112 anti-HIV_V3_HeavyChain 1357 22-41 51-60 94-113 anti-HIV_V3_HeavyChain 1358 22-41 51-60 anti-HIV_V3_HeavyChain 1359 22-41 anti-HIV_V3_HeavyChain 1360 22-41 94-113 anti-HIV_V3_HeavyChain 1361 22-41 94-113 anti-HIV_V3_HeavyChain 1362 22-41 94-113 anti-HIV_V3_HeavyChain 1363 22-41 94-113 anti-HIV_V3_HeavyChain 1364 22-41 anti-HIV_CD4bs_HeavyChain 1365 22-41 58-67 94-113 anti-HIV_CD4bs_HeavyChain 1366 22-41 94-113 anti-HIV_CD4bs_HeavyChain 1367 22-41 93-112 anti-HIV_CD4bs_HeavyChain 1368 22-41 53-62 anti-HIV_CD4bs_HeavyChain 1369 22-41 96-115 anti-HIV_CD4bs_HeavyChain 1370 22-41 94-113 anti-HIV_CD4bs_HeavyChain 1371 22-41 94-113 anti-HIV_CD4bs_HeavyChain 1372 22-41 anti-HIV_CD4bs_HeavyChain 1373 22-41 anti-HIV_CD4bs_HeavyChain 1374 22-41 94-113 anti-HIV_V2_HeavyChain 1375 22-41 94-113 anti-HIV_V2_HeavyChain 1376 22-41 94-113 anti-HIV_V2_HeavyChain 1377 22-41 94-113 anti-HIV_V2_HeavyChain 1378 22-41 93-112 anti-HIV_V2_HeavyChain 1379 22-41 94-113 anti-HIV_V2_HeavyChain 1380 22-41 94-113 anti-HIV_V3_LightChain 1381 22-41 47-56 anti-HIV_V3_LightChain 1382 22-41 85-104 anti-HIV_V3_LightChain 1383 22-41 49-58 87-106 anti-HIV_V3_LightChain 1384 22-41  91-100 92-111 anti-HIV_V3_LightChain 1385 22-41 47-56 85-104 anti-HIV_V3_LightChain 1386 22-41 49-58 87-106 anti-HIV_V3_LightChain 1387 22-41 85-104 anti-HIV_V3_LightChain 1388 22-41 47-56 85-104 anti-HIV_V3_LightChain 1389 22-41 50-59 88-107 anti-HIV_V3_LightChain 1390 22-41 49-58 87-106 anti-HIV_V3_LightChain 1391 22-41 86-105 anti-HIV_V3_LightChain 1392 22-41 85-94 86-105 anti-HIV_V3_LightChain 1393 22-41 85-104 anti-HIV_V3_LightChain 1394 22-41 48-57 anti-HIV_V3_LightChain 1395 22-41 49-58 89-108 anti-HIV_V3_LightChain 1396 22-41 49-58 87-106 anti-HIV_V3_LightChain 1397 22-41 85-104 anti-HIV_V3_LightChain 1398 22-41 49-58 87-106 anti-HIV_V3_LightChain 1399 22-41 53-62 91-110 anti-HIV_V3_LightChain 1400 22-41 85-104 anti-HIV_V3_LightChain 1401 22-41 49-58 anti-HIV_V3_LightChain 1402 22-41 anti-HIV_V3_LightChain 1403 22-41 47-56 85-104 anti-HIV_V3_LightChain 1404 22-41 48-57 86-105 anti-HIV_V3_LightChain 1405 22-41 85-104 anti-HIV_V3_LightChain 1406 22-41 49-58 anti-HIV_V3_LightChain 1407 22-41 48-57 86-105 anti-HIV_V3_LightChain 1408 22-41 85-104 anti-HIV_V3_LightChain 1409 22-41 47-56 85-104 anti-HIV_V3_LightChain 1410 22-41 47-56 85-104 anti-HIV_CD4bs_LightChain 1411 22-41 90-109 anti-HIV_CD4bs_LightChain 1412 22-41 49-58 87-106 anti-HIV_CD4bs_LightChain 1413 22-41 50-59 88-107 anti-HIV_CD4bs_LightChain 1414 22-41 36-45 91-110 anti-HIV_CD4bs_LightChain 1415 22-41 49-58 87-106 anti-HIV_CD4bs_LightChain 1416 22-41 49-58 89-108 anti-HIV_CD4bs_LightChain 1417 22-41 53-62 91-110 anti-HIV_CD4bs_LightChain 1418 22-41 88-107 anti-HIV_CD4bs_LightChain 1419 22-41 29-38 86-105 anti-HIV_CD4bs_LightChain 1420 22-41 88-107 anti-HIV_V2_LightChain 1421 22-41 48-57 86-105 anti-HIV_V2_LightChain 1422 22-41 48-57 86-105 anti-HIV_V2_LightChain 1423 22-41 50-59 88-107 anti-HIV_V2_LightChain 1424 22-41 48-57 86-105 anti-HIV_V2_LightChain 1425 22-41 49-58 87-106 anti-HIV_V2_LightChain 1426 22-41 48-57 anti-HIV_10E8 1427 22-41 47-56 85-104 anti-HIV_10E8 1428 22-41 47-56 85-104 anti-HIV_10E8 1429 22-41 47-56 85-104 anti-HIV_10E8 1430 22-41 47-56 85-104 anti-HIV_10E8 1431 22-41 47-56 85-104 anti-HIV_10E8 1432 22-41 47-56 85-104 anti-HIV_10E8 1433 22-41 47-56 85-104 anti-HIV_10E8 1434 22-41 47-56 85-104 anti-HIV_10E8 1435 22-41 85-104 anti-HIV_10E8 1436 22-41 85-104 anti-HIV_10E8 1437 22-41 85-104 anti-HIV_10E8 1438 22-41 85-104 anti-HIV_10E8 1439 22-41 85-104 anti-HIV_10E8 1440 22-41 85-104 anti-HIV_10E8 1441 22-41 85-104 anti-HIV_10E8 1442 22-41 85-104 anti-HIV_10E8 1443 22-41 85-104 anti-HIV_10E8 1444 22-41 85-104 anti-HIV_10E8 1445 22-41 85-104 anti-HIV_10E8 1446 22-41 anti-HIV_10E8 1447 22-41 85-104 anti-HIV_10E8 1448 22-41 85-104 anti-HIV_10E8 1449 22-41 96-115 anti-HIV_10E8 1450 22-41 anti-HIV_10E8 1451 22-41 anti-HIV_10E8 1452 22-41 anti-HIV_10E8 1453 22-41 anti-HIV_10E8 1454 22-41 anti-HIV_10E8 1455 22-41 anti-HIV_10E8 1456 22-41 anti-HIV_10E8 1457 22-41 anti-HIV_10E8 1458 22-41 anti-HIV-1_LightChain 1459 22-41 49-58 87-106 anti-HIV-1_LightChain 1460 22-41 50-59 88-107 anti-HIV-1_LightChain 1461 22-41 45-54 83-102 anti-HIV-1_LightChain 1462 22-41 49-58 87-106 anti-HIV-1_LightChain 1463 22-41 49-58 87-106 anti-HIV-1_LightChain 1464 22-41 87-106 anti-HIV-1_LightChain 1465 22-41 49-58 87-106 anti-HIV-1_LightChain 1466 22-41 49-58 87-106 anti-HIV-1_LightChain 1467 22-41 34-43 72-91  anti-HIV-1_LightChain 1468 22-41 87-106 anti-HIV-1_LightChain 1469 22-41 49-58 87-106 anti-HIV-1_LightChain 1470 22-41 87-106 anti-HIV-1_LightChain 1471 22-41 50-59 88-107 anti-HIV-1_LightChain 1472 22-41 87-106 anti-HIV-1_LightChain 1473 22-41 50-59 88-107 anti-HIV-1_LightChain 1474 22-41 49-58 87-106 anti-HIV-1_LightChain 1475 22-41 49-58 87-106 anti-HIV-1_LightChain 1476 22-41 49-58 87-106 anti-HIV-1_LightChain 1477 22-41 49-58 87-106 anti-HIV-1_LightChain 1478 22-41 49-58 87-106 anti-HIV-1_LightChain 1479 22-41 50-59 88-107 anti-HIV-1_LightChain 1480 22-41 49-58 87-106 anti-HIV-1_LightChain 1481 22-41 87-106 anti-HIV-1_LightChain 1482 22-41 49-58 87-106 anti-HIV-1_LightChain 1483 22-41 49-58 87-106 anti-HIV-1_LightChain 1484 22-41 49-58 87-106 anti-HIV-1_LightChain 1485 22-41 50-59 88-107 anti-HIV-1_LightChain 1486 22-41 49-58 87-106 anti-HIV-1_LightChain 1487 22-41 87-106 anti-HIV-1_LightChain 1488 22-41 49-58 87-106 anti-HIV-1_LightChain 1489 22-41 49-58 87-106 anti-HIV-1_LightChain 1490 22-41 49-58 87-106 anti-HIV-1_LightChain 1491 22-41 87-106 anti-HIV-1_LightChain 1492 22-41 49-58 87-106 anti-HIV-1_LightChain 1493 22-41 49-58 87-106 anti-HIV-1_LightChain 1494 22-41 50-59 88-107 anti-HIV-1_LightChain 1495 22-41 49-58 87-106 anti-HIV-1_LightChain 1496 22-41 49-58 87-106 anti-HIV-1_LightChain 1497 22-41 49-58 87-106 anti-HIV-1_LightChain 1498 22-41 49-58 87-106 anti-HIV-1_LightChain 1499 22-41 49-58 87-106 anti-HIV-1_LightChain 1500 22-41 50-59 88-107 anti-HIV-1_LightChain 1501 22-41 49-58 87-106 anti-HIV-1_LightChain 1502 22-41 49-58 87-106 anti-HIV-1_LightChain 1503 22-41 50-59 88-107 anti-HIV-1_LightChain 1504 22-41 49-58 87-106 anti-HIV-1_LightChain 1505 22-41 49-58 87-106 anti-HIV-1_LightChain 1506 22-41 49-58 87-106 anti-HIV-1_LightChain 1507 22-41 49-58 87-106 anti-HIV-1_LightChain 1508 22-41 49-58 87-106 anti-HIV-1_LightChain 1509 22-41 49-58 87-106 anti-HIV-1_LightChain 1510 22-41 49-58 87-106 anti-HIV-1_LightChain 1511 22-41 50-59 88-107 anti-HIV-1_LightChain 1512 22-41 50-59 88-107 anti-HIV-1_LightChain 1513 22-41 49-58 87-106 anti-HIV-1_LightChain 1514 22-41 49-58 87-106 anti-HIV-1_LightChain 1515 22-41 87-106 anti-HIV-1_LightChain 1516 22-41 49-58 87-106 anti-HIV-1_LightChain 1517 22-41 49-58 87-106 anti-HIV-1_LightChain 1518 22-41 49-58 87-106 anti-HIV-1_LightChain 1519 22-41 32-41 87-106 anti-HIV-1_LightChain 1520 22-41 49-58 87-106 anti-HIV-1_LightChain 1521 22-41 50-59 88-107 anti-HIV-1_LightChain 1522 22-41 87-106 anti-HIV-1_LightChain 1523 22-41 49-58 87-106 anti-HIV-1_LightChain 1524 22-41 49-58 87-106 anti-HIV-1_LightChain 1525 22-41 50-59 88-107 anti-HIV-1_LightChain 1526 22-41 87-106 anti-HIV-1_LightChain 1527 22-41 49-58 87-106 anti-HIV-1_LightChain 1528 22-41 49-58 87-106 anti-HIV-1_LightChain 1529 22-41 87-106 anti-HIV-1_LightChain 1530 22-41 87-106 anti-HIV-1_LightChain 1531 22-41 49-58 87-106 anti-HIV-1_LightChain 1532 22-41 87-106 anti-HIV-1_LightChain 1533 22-41 49-58 87-106 anti-HIV-1_LightChain 1534 22-41 49-58 87-106 anti-HIV-1_LightChain 1535 22-41 49-58 87-106 anti-HIV-1_LightChain 1536 22-41 49-58 87-106 anti-HIV-1_LightChain 1537 22-41 49-58 87-106 anti-HIV-1_LightChain 1538 22-41 50-59 88-107 anti-HIV-1_LightChain 1539 22-41 50-59 88-107 anti-HIV-1_LightChain 1540 22-41 87-106 anti-HIV-1_LightChain 1541 22-41 49-58 87-106 anti-HIV-1_LightChain 1542 22-41 88-107 anti-HIV-1_LightChain 1543 22-41 49-58 87-106 anti-HIV-1_LightChain 1544 22-41 49-58 87-106 anti-HIV-1_LightChain 1545 22-41 49-58 87-106 anti-HIV-1_LightChain 1546 22-41 49-58 87-106 anti-HIV-1_LightChain 1547 22-41 87-106 anti-HIV-1_LightChain 1548 22-41 87-106 anti-HIV-1_LightChain 1549 22-41 50-59 88-107 anti-HIV-1_LightChain 1550 22-41 49-58 87-106 anti-HIV-1_LightChain 1551 22-41 50-59 88-107 anti-HIV-1_LightChain 1552 22-41 49-58 87-106 anti-HIV-1_LightChain 1553 22-41 87-106 anti-HIV-1_LightChain 1554 22-41 49-58 87-106 anti-HIV-1_LightChain 1555 22-41 50-59 88-107 anti-HIV-1_LightChain 1556 22-41 49-58 87-106 anti-HIV-1_LightChain 1557 22-41 49-58 87-106 anti-HIV-1_LightChain 1558 22-41 49-58 87-106 anti-HIV-1_LightChain 1559 22-41 49-58 87-106 anti-HIV-1_LightChain 1560 22-41 49-58 87-106 anti-HIV-1_LightChain 1561 22-41 49-58 87-106 anti-HIV-1_LightChain 1562 22-41 49-58 87-106 anti-HIV-1_LightChain 1563 22-41 49-58 87-106 anti-HIV-1_LightChain 1564 22-41 49-58 87-106 anti-HIV-1_LightChain 1565 22-41 49-58 87-106 anti-HIV-1_LightChain 1566 22-41 49-58 87-106 anti-HIV-1_LightChain 1567 22-41 49-58 87-106 anti-HIV-1_LightChain 1568 22-41 49-58 87-106 anti-HIV-1_LightChain 1569 22-41 45-54 83-102 anti-HIV-1_LightChain 1570 22-41 49-58 87-106 anti-HIV-1_LightChain 1571 22-41 49-58 87-106 anti-HIV-1_LightChain 1572 22-41 49-58 87-106 anti-HIV-1_LightChain 1573 22-41 50-59 88-107 anti-HIV-1_LightChain 1574 22-41 49-58 87-106 anti-HIV-1_LightChain 1575 22-41 49-58 87-106 anti-HIV-1_LightChain 1576 22-41 49-58 87-106 anti-HIV-1_LightChain 1577 22-41 49-58 87-106 anti-HIV-1_LightChain 1578 22-41 49-58 87-106 anti-HIV-1_LightChain 1579 22-41 32-41 87-106 anti-HIV-1_LightChain 1580 22-41 49-58 87-106 anti-HIV-1_LightChain 1581 22-41 49-58 87-106 anti-HIV-1_LightChain 1582 22-41 50-59 88-107 anti-HIV-1_LightChain 1583 22-41 49-58 87-106 anti-HIV-1_LightChain 1584 22-41 88-107 anti-HIV-1_LightChain 1585 22-41 49-58 87-106 anti-HIV-1_LightChain 1586 22-41 49-58 87-106 anti-HIV-1_LightChain 1587 22-41 45-54 83-102 anti-HIV-1_LightChain 1588 22-41 49-58 87-106 anti-HIV-1_LightChain 1589 22-41 49-58 87-106 anti-HIV-1_LightChain 1590 22-41 49-58 87-106 anti-HIV-1_LightChain 1591 22-41 88-107 anti-HIV-1_LightChain 1592 22-41 49-58 87-106 anti-HIV-1_LightChain 1593 22-41 49-58 87-106 anti-HIV-1_LightChain 1594 22-41 49-58 87-106 anti-HIV-1_LightChain 1595 22-41 49-58 87-106 anti-HIV-1_LightChain 1596 22-41 49-58 87-106 anti-HIV-1_LightChain 1597 22-41 49-58 87-106 anti-HIV-1_LightChain 1598 22-41 88-107 anti-HIV-1_LightChain 1599 22-41 49-58 87-106 anti-HIV-1_LightChain 1600 22-41 49-58 87-106 anti-HIV-1_LightChain 1601 22-41 87-106 anti-HIV-1_LightChain 1602 22-41 49-58 87-106 anti-HIV-1_LightChain 1603 22-41 49-58 87-106 anti-HIV-1_LightChain 1604 22-41 49-58 87-106 anti-HIV-1_LightChain 1605 22-41 49-58 87-106 anti-HIV-1_LightChain 1606 22-41 49-58 87-106 anti-HIV-1_LightChain 1607 22-41 49-58 87-106 anti-HIV-1_LightChain 1608 22-41 49-58 87-106 anti-HIV-1_HeavyChain 1609 22-41 94-113 anti-HIV-1_HeavyChain 1610 22-41 94-113 anti-HIV-1_HeavyChain 1611 22-41 94-113 anti-HIV-1_HeavyChain 1612 22-41 94-113 anti-HIV-1_HeavyChain 1613 22-41 anti-HIV-1_HeavyChain 1614 22-41 94-113 anti-HIV-1_HeavyChain 1615 22-41 20-29 94-113 anti-HIV-1_HeavyChain 1616 22-41 94-113 anti-HIV-1_HeavyChain 1617 22-41 anti-HIV-1_HeavyChain 1618 22-41 94-113 anti-HIV-1_HeavyChain 1619 22-41 94-113 anti-HIV-1_HeavyChain 1620 22-41 31-40 94-113 anti-HIV-1_HeavyChain 1621 22-41 94-113 anti-HIV-1_HeavyChain 1622 22-41 94-113 anti-HIV-1_HeavyChain 1623 22-41 94-113 anti-HIV-1_HeavyChain 1624 22-41 94-113 anti-HIV-1_HeavyChain 1625 22-41 94-113 anti-HIV-1_HeavyChain 1626 22-41 94-113 anti-HIV-1_HeavyChain 1627 22-41 anti-HIV-1_HeavyChain 1628 22-41 anti-HIV-1_HeavyChain 1629 22-41 94-113 anti-HIV-1_HeavyChain 1630 22-41 94-113 anti-HIV-1_HeavyChain 1631 22-41 94-113 anti-HIV-1_HeavyChain 1632 22-41 94-113 anti-HIV-1_HeavyChain 1633 22-41 anti-HIV-1_HeavyChain 1634 22-41 94-113 anti-HIV-1_HeavyChain 1635 22-41 94-113 anti-HIV-1_HeavyChain 1636 22-41 94-113 anti-HIV-1_HeavyChain 1637 22-41 94-113 anti-HIV-1_HeavyChain 1638 22-41 94-113 anti-HIV-1_HeavyChain 1639 22-41 94-113 anti-HIV-1_HeavyChain 1640 22-41 94-113 anti-HIV-1_HeavyChain 1641 22-41 93-112 anti-HIV-1_HeavyChain 1642 22-41 94-113 anti-HIV-1_HeavyChain 1643 22-41 94-113 anti-HIV-1_HeavyChain 1644 22-41 94-113 anti-HIV-1_HeavyChain 1645 22-41 94-113 anti-HIV-1_HeavyChain 1646 22-41 94-113 anti-HIV-1_HeavyChain 1647 22-41 20-29 94-113 anti-HIV-1_HeavyChain 1648 22-41 94-113 anti-HIV-1_HeavyChain 1649 22-41 anti-HIV-1_HeavyChain 1650 22-41 94-113 anti-HIV-1_HeavyChain 1651 22-41 94-113 anti-HIV-1_HeavyChain 1652 22-41 94-113 anti-HIV-1_HeavyChain 1653 22-41 94-113 anti-HIV-1_HeavyChain 1654 22-41 94-113 anti-HIV-1_HeavyChain 1655 22-41 94-113 anti-HIV_C38-VRC18.02_HeavyChain 1656 22-41 anti-HIV_44-VRC13.02_HeavyChain 1657 22-41 anti-HIV-1_LightChain 1658 22-41 86-105 anti-HIV-1_LightChain 1659 22-41 86-105 anti-HIV-1_LightChain 1660 22-41 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1818 22-41 anti-HIV_cap256-119-125765_VR-Chain 1819 22-41 94-113 anti-HIV_cap256-119-125106_VR-Chain 1820 22-41 anti-HIV_cap256-119-124026_VR-Chain 1821 22-41 94-113 anti-HIV_cap256-119-121783_VR-Chain 1822 22-41 anti-HIV_cap256-119-121208_VR-Chain 1823 22-41 94-113 anti-HIV_cap256-119-120945_VR-Chain 1824 22-41 anti-HIV_cap256-119-118229_VR-Chain 1825 22-41 94-113 anti-HIV_cap256-119-118025_VR-Chain 1826 22-41 anti-HIV_cap256-119-117418_VR-Chain 1827 22-41 anti-HIV_cap256-119-117250_VR-Chain 1828 22-41 94-113 anti-HIV_cap256-119-117230_VR-Chain 1829 22-41 94-113 anti-HIV_cap256-119-116999_VR-Chain 1830 22-41 anti-HIV_cap256-119-116558_VR-Chain 1831 22-41 94-113 anti-HIV_cap256-119-116484_VR-Chain 1832 22-41 94-113 anti-HIV_cap256-119-114844_VR-Chain 1833 22-41 anti-HIV_cap256-119-114141_VR-Chain 1834 22-41 anti-HIV_cap256-119-111917_VR-Chain 1835 22-41 94-113 anti-HIV_cap256-119-111862_VR-Chain 1836 22-41 94-113 anti-HIV_cap256-119-110064_VR-Chain 1837 22-41 94-113 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94-113 anti-HIV_cap256-119-100838_VR-Chain 1858 22-41 94-113 anti-HIV_cap256-119-100025_VR-Chain 1859 22-41 anti-HIV_cap256-119-100000_VR-Chain 1860 22-41 anti-HIV_cap256-119-098890_VR-Chain 1861 22-41 94-113 anti-HIV_cap256-119-098715_VR-Chain 1862 22-41 94-113 anti-HIV_cap256-119-098632_VR-Chain 1863 22-41 anti-HIV_cap256-119-097199_VR-Chain 1864 22-41 anti-HIV_cap256-119-096189_VR-Chain 1865 22-41 anti-HIV_cap256-119-094581_VR-Chain 1866 22-41 94-113 anti-HIV_cap256-119-094200_VR-Chain 1867 22-41 94-113 anti-HIV_cap256-119-094158_VR-Chain 1868 22-41 anti-HIV_cap256-119-092814_VR-Chain 1869 22-41 anti-HIV_cap256-119-092808_VR-Chain 1870 22-41 anti-HIV_cap256-119-092573_VR-Chain 1871 22-41 94-113 anti-HIV_cap256-119-090815_VR-Chain 1872 22-41 anti-HIV_cap256-119-090368_VR-Chain 1873 22-41 anti-HIV_cap256-119-089710_VR-Chain 1874 22-41 anti-HIV_cap256-119-088555_VR-Chain 1875 22-41 94-113 anti-HIV_cap256-119-087962_VR-Chain 1876 22-41 94-113 anti-HIV_cap256-119-086903_VR-Chain 1877 22-41 94-113 anti-HIV_cap256-119-086804_VR-Chain 1878 22-41 94-113 anti-HIV_cap256-119-085910_VR-Chain 1879 22-41 anti-HIV_cap256-119-085772_VR-Chain 1880 22-41 94-113 anti-HIV_cap256-119-084603_VR-Chain 1881 22-41 94-113 anti-HIV_cap256-119-084276_VR-Chain 1882 22-41 anti-HIV_cap256-119-082288_VR-Chain 1883 22-41 94-113 anti-HIV_cap256-119-080383_VR-Chain 1884 22-41 94-113 anti-HIV_cap256-119-079333_VR-Chain 1885 22-41 anti-HIV_cap256-119-078618_VR-Chain 1886 22-41 anti-HIV_cap256-119-077466_VR-Chain 1887 22-41 94-113 anti-HIV_cap256-119-076284_VR-Chain 1888 22-41 anti-HIV_cap256-119-074680_VR-Chain 1889 22-41 94-113 anti-HIV_cap256-119-074081_VR-Chain 1890 22-41 94-113 anti-HIV_cap256-119-071704_VR-Chain 1891 22-41 anti-HIV_cap256-119-071266_VR-Chain 1892 22-41 94-113 anti-HIV_cap256-119-069667_VR-Chain 1893 22-41 94-113 anti-HIV_cap256-119-069591_VR-Chain 1894 22-41 94-113 anti-HIV_cap256-119-068691_VR-Chain 1895 22-41 94-113 anti-HIV_cap256-119-068488_VR-Chain 1896 22-41 94-113 anti-HIV_cap256-119-067536_VR-Chain 1897 22-41 anti-HIV_cap256-119-065852_VR-Chain 1898 22-41 94-113 anti-HIV_cap256-119-065457_VR-Chain 1899 22-41 94-113 anti-HIV_cap256-119-064501_VR-Chain 1900 22-41 anti-HIV_cap256-119-063568_VR-Chain 1901 22-41 94-113 anti-HIV_cap256-119-063103_VR-Chain 1902 22-41 94-113 anti-HIV_cap256-119-061027_VR-Chain 1903 22-41 94-113 anti-HIV_cap256-119-058232_VR-Chain 1904 22-41 94-113 anti-HIV_cap256-119-057341_VR-Chain 1905 22-41 94-113 anti-HIV_cap256-119-056895_VR-Chain 1906 22-41 anti-HIV_cap256-119-056402_VR-Chain 1907 22-41 anti-HIV_cap256-119-056034_VR-Chain 1908 22-41 94-113 anti-HIV_cap256-119-055042_VR-Chain 1909 22-41 94-113 anti-HIV_cap256-119-054776_VR-Chain 1910 22-41 anti-HIV_cap256-119-054539_VR-Chain 1911 22-41 anti-HIV_cap256-119-054112_VR-Chain 1912 22-41 94-113 anti-HIV_cap256-119-053339_VR-Chain 1913 22-41  93-102 94-113 anti-HIV_cap256-119-052404_VR-Chain 1914 22-41 anti-HIV_cap256-119-051123_VR-Chain 1915 22-41 94-113 anti-HIV_cap256-119-051077_VR-Chain 1916 22-41 anti-HIV_cap256-119-050442_VR-Chain 1917 22-41 94-113 anti-HIV_cap256-119-049433_VR-Chain 1918 22-41 94-113 anti-HIV_cap256-119-047532_VR-Chain 1919 22-41 94-113 anti-HIV_cap256-119-047489_VR-Chain 1920 22-41 94-113 anti-HIV_cap256-119-046020_VR-Chain 1921 22-41 anti-HIV_cap256-119-044746_VR-Chain 1922 22-41 94-113 anti-HIV_cap256-119-044740_VR-Chain 1923 22-41 anti-HIV_cap256-119-043790_VR-Chain 1924 22-41 94-113 anti-HIV_cap256-119-042880_VR-Chain 1925 22-41 94-113 anti-HIV_cap256-119-042606_VR-Chain 1926 22-41 94-113 anti-HIV_cap256-119-042444_VR-Chain 1927 22-41 anti-HIV_cap256-119-040328_VR-Chain 1928 22-41 94-113 anti-HIV_cap256-119-040164_VR-Chain 1929 22-41 anti-HIV_cap256-119-039130_VR-Chain 1930 22-41 anti-HIV_cap256-119-038138_VR-Chain 1931 22-41 anti-HIV_cap256-119-037868_VR-Chain 1932 22-41 anti-HIV_cap256-119-037102_VR-Chain 1933 22-41 94-113 anti-HIV_cap256-119-036683_VR-Chain 1934 22-41 anti-HIV_cap256-119-036495_VR-Chain 1935 22-41 anti-HIV_cap256-119-035375_VR-Chain 1936 22-41 anti-HIV_cap256-119-035165_VR-Chain 1937 22-41 anti-HIV_cap256-119-035109_VR-Chain 1938 22-41 94-113 anti-HIV_cap256-119-033789_VR-Chain 1939 22-41 63-82  anti-HIV_cap256-119-033641_VR-Chain 1940 22-41 anti-HIV_cap256-119-032113_VR-Chain 1941 22-41 94-113 anti-HIV_cap256-119-031739_VR-Chain 1942 22-41 94-113 anti-HIV_cap256-119-030932_VR-Chain 1943 22-41 94-113 anti-HIV_cap256-119-030740_VR-Chain 1944 22-41 anti-HIV_cap256-119-030197_VR-Chain 1945 22-41 94-113 anti-HIV_cap256-119-027047_VR-Chain 1946 22-41 anti-HIV_cap256-119-026950_VR-Chain 1947 22-41 94-113 anti-HIV_cap256-119-026279_VR-Chain 1948 22-41 anti-HIV_cap256-119-025355_VR-Chain 1949 22-41 anti-HIV_cap256-119-025301_VR-Chain 1950 22-41 94-113 anti-HIV_cap256-119-025010_VR-Chain 1951 22-41 anti-HIV_cap256-119-024631_VR-Chain 1952 22-41 anti-HIV_cap256-119-024467_VR-Chain 1953 22-41 94-113 anti-HIV_cap256-119-023805_VR-Chain 1954 22-41 94-113 anti-HIV_cap256-119-021736_VR-Chain 1955 22-41 94-113 anti-HIV_cap256-119-021203_VR-Chain 1956 22-41 anti-HIV_cap256-119-020569_VR-Chain 1957 22-41 94-113 anti-HIV_cap256-119-019432_VR-Chain 1958 22-41 94-113 anti-HIV_cap256-119-018827_VR-Chain 1959 22-41 94-113 anti-HIV_cap256-119-018483_VR-Chain 1960 22-41 anti-HIV_cap256-119-018118_VR-Chain 1961 22-41 94-113 anti-HIV_cap256-119-017782_VR-Chain 1962 22-41 anti-HIV_cap256-119-017669_VR-Chain 1963 22-41 94-113 anti-HIV_cap256-119-016976_VR-Chain 1964 22-41 94-113 anti-HIV_cap256-119-015432_VR-Chain 1965 22-41 94-113 anti-HIV_cap256-119-015281_VR-Chain 1966 22-41 94-113 anti-HIV_cap256-119-014957_VR-Chain 1967 22-41 94-113 anti-HIV_cap256-119-014777_VR-Chain 1968 22-41 94-113 anti-HIV_cap256-119-014313_VR-Chain 1969 22-41 anti-HIV_cap256-119-014219_VR-Chain 1970 22-41 anti-HIV_cap256-119-013631_VR-Chain 1971 22-41 anti-HIV_cap256-119-012924_VR-Chain 1972 22-41 anti-HIV_cap256-119-011793_VR-Chain 1973 22-41 94-113 anti-HIV_cap256-119-011413_VR-Chain 1974 22-41 94-113 anti-HIV_cap256-119-011323_VR-Chain 1975 22-41 94-113 anti-HIV_cap256-119-011233_VR-Chain 1976 22-41 94-113 anti-HIV_cap256-119-009038_VR-Chain 1977 22-41 94-113 anti-HIV_cap256-119-008756_VR-Chain 1978 22-41 94-113 anti-HIV_cap256-119-008055_VR-Chain 1979 22-41 anti-HIV_cap256-119-006949_VR-Chain 1980 22-41 94-113 anti-HIV_cap256-119-006685_VR-Chain 1981 22-41 anti-HIV_cap256-119-006015_VR-Chain 1982 22-41 94-113 anti-HIV_cap256-119-005841_VR-Chain 1983 22-41 94-113 anti-HIV_cap256-119-005824_VR-Chain 1984 22-41 94-113 anti-HIV_cap256-119-005494_VR-Chain 1985 22-41 94-113 anti-HIV_cap256-119-004949_VR-Chain 1986 22-41 anti-HIV_cap256-119-004422_VR-Chain 1987 22-41 94-113 anti-HIV_cap256-119-003932_VR-Chain 1988 22-41 anti-HIV_cap256-119-003577_VR-Chain 1989 22-41 anti-HIV_cap256-119-002155_VR-Chain 1990 22-41 94-113 anti-HIV_cap256-119-002017_VR-Chain 1991 22-41 anti-HIV_cap256-119-001312_VR-Chain 1992 22-41 94-113 anti-HIV_cap256-119-001017_VR-Chain 1993 22-41 anti-HIV_cap256-119-000594_VR-Chain 1994 22-41 94-113 anti-HIV_cap256-059-241099_VR-Chain 1995 22-41 94-113 anti-HIV_cap256-059-207529_VR-Chain 1996 22-41 94-113 anti-HIV_cap256-059-205541_VR-Chain 1997 22-41 94-113 anti-HIV_cap256-059-188439_VR-Chain 1998 22-41 94-113 anti-HIV_cap256-059-187234_VR-Chain 1999 22-41 94-113 anti-HIV_cap256-059-187047_VR-Chain 2000 22-41 94-113 anti-HIV_cap256-059-186068_VR-Chain 2001 22-41 94-113 anti-HIV_cap256-059-182835_VR-Chain 2002 22-41 94-113 anti-HIV_cap256-059-176659_VR-Chain 2003 22-41 94-113 anti-HIV_cap256-059-172956_VR-Chain 2004 22-41 94-113 anti-HIV_cap256-059-171272_VR-Chain 2005 22-41 94-113 anti-HIV_cap256-059-168734_VR-Chain 2006 22-41 94-113 anti-HIV_cap256-059-155838_VR-Chain 2007 22-41 94-113 anti-HIV_cap256-059-149799_VR-Chain 2008 22-41 94-113 anti-HIV_cap256-059-148168_VR-Chain 2009 22-41 anti-HIV_cap256-059-144685_VR-Chain 2010 22-41 94-113 anti-HIV_cap256-059-140017_VR-Chain 2011 22-41 94-113 anti-HIV_cap256-059-137547_VR-Chain 2012 22-41 94-113 anti-HIV_cap256-059-131908_VR-Chain 2013 22-41 94-113 anti-HIV_cap256-059-116006_VR-Chain 2014 22-41 94-113 anti-HIV_cap256-059-115783_VR-Chain 2015 22-41 87-106 anti-HIV_cap256-059-114609_VR-Chain 2016 22-41 anti-HIV_cap256-059-113952_VR-Chain 2017 22-41 94-113 anti-HIV_cap256-059-113878_VR-Chain 2018 22-41 94-113 anti-HIV_cap256-059-113622_VR-Chain 2019 22-41 94-113 anti-HIV_cap256-059-109427_VR-Chain 2020 22-41 94-113 anti-HIV_cap256-059-109081_VR-Chain 2021 22-41 94-113 anti-HIV_cap256-059-107590_VR-Chain 2022 22-41 94-113 anti-HIV_cap256-059-107504_VR-Chain 2023 22-41 94-113 anti-HIV_cap256-059-099614_VR-Chain 2024 22-41 94-113 anti-HIV_cap256-059-098972_VR-Chain 2025 22-41 94-113 anti-HIV_cap256-059-097236_VR-Chain 2026 22-41 94-113 anti-HIV_cap256-059-091487_VR-Chain 2027 22-41 94-113 anti-HIV_cap256-059-089812_VR-Chain 2028 22-41 94-113 anti-HIV_cap256-059-088468_VR-Chain 2029 22-41 94-113 anti-HIV_cap256-059-088341_VR-Chain 2030 22-41 94-113 anti-HIV_cap256-059-086533_VR-Chain 2031 22-41 94-113 anti-HIV_cap256-059-086043_VR-Chain 2032 22-41  93-102 94-113 anti-HIV_cap256-059-084191_VR-Chain 2033 22-41 94-113 anti-HIV_cap256-059-082135_VR-Chain 2034 22-41 94-113 anti-HIV_cap256-059-079417_VR-Chain 2035 22-41 94-113 anti-HIV_cap256-059-076027_VR-Chain 2036 22-41  93-102 94-113 anti-HIV_cap256-059-075082_VR-Chain 2037 22-41 94-113 anti-HIV_cap256-059-072575_VR-Chain 2038 22-41 94-113 anti-HIV_cap256-059-071926_VR-Chain 2039 22-41 94-113 anti-HIV_cap256-059-069638_VR-Chain 2040 22-41 94-113 anti-HIV_cap256-059-069165_VR-Chain 2041 22-41 94-113 anti-HIV_cap256-059-068956_VR-Chain 2042 22-41 94-113 anti-HIV_cap256-059-068876_VR-Chain 2043 22-41 94-113 anti-HIV_cap256-059-067733_VR-Chain 2044 22-41 94-113 anti-HIV_cap256-059-067450_VR-Chain 2045 22-41 94-113 anti-HIV_cap256-059-065694_VR-Chain 2046 22-41 94-113 anti-HIV_cap256-059-065109_VR-Chain 2047 22-41 94-113 anti-HIV_cap256-059-065060_VR-Chain 2048 22-41 anti-HIV_cap256-059-064001_VR-Chain 2049 22-41 94-113 anti-HIV_cap256-059-063270_VR-Chain 2050 22-41 94-113 anti-HIV_cap256-059-061357_VR-Chain 2051 22-41 58-67 anti-HIV_cap256-059-059834_VR-Chain 2052 22-41 94-113 anti-HIV_cap256-059-059313_VR-Chain 2053 22-41 94-113 anti-HIV_cap256-059-057130_VR-Chain 2054 22-41 94-113 anti-HIV_cap256-059-050520_VR-Chain 2055 22-41 87-106 anti-HIV_cap256-059-049839_VR-Chain 2056 22-41 94-113 anti-HIV_cap256-059-048503_VR-Chain 2057 22-41 94-113 anti-HIV_cap256-059-045516_VR-Chain 2058 22-41 94-113 anti-HIV_cap256-059-044188_VR-Chain 2059 22-41 94-113 anti-HIV_cap256-059-044105_VR-Chain 2060 22-41  93-102 94-113 anti-HIV_cap256-059-042100_VR-Chain 2061 22-41 anti-HIV_cap256-059-040742_VR-Chain 2062 22-41 94-113 anti-HIV_cap256-059-040554_VR-Chain 2063 22-41 94-113 anti-HIV_cap256-059-039660_VR-Chain 2064 22-41 94-113 anti-HIV_cap256-059-039298_VR-Chain 2065 22-41 94-113 anti-HIV_cap256-059-037873_VR-Chain 2066 22-41 94-113 anti-HIV_cap256-059-037633_VR-Chain 2067 22-41 94-113 anti-HIV_cap256-059-036817_VR-Chain 2068 22-41 94-113 anti-HIV_cap256-059-032787_VR-Chain 2069 22-41 94-113 anti-HIV_cap256-059-032427_VR-Chain 2070 22-41 94-113 anti-HIV_cap256-059-029390_VR-Chain 2071 22-41 94-113 anti-HIV_cap256-059-027877_VR-Chain 2072 22-41 94-113 anti-HIV_cap256-059-026640_VR-Chain 2073 22-41  93-102 94-113 anti-HIV_cap256-059-026017_VR-Chain 2074 22-41 anti-HIV_cap256-059-024100_VR-Chain 2075 22-41 94-113 anti-HIV_cap256-059-023966_VR-Chain 2076 22-41 94-113 anti-HIV_cap256-059-020534_VR-Chain 2077 22-41 94-113 anti-HIV_cap256-059-019513_VR-Chain 2078 22-41 94-113 anti-HIV_cap256-059-012963_VR-Chain 2079 22-41 94-113 anti-HIV_cap256-059-010396_VR-Chain 2080 22-41 94-113 anti-HIV_cap256-059-008136_VR-Chain 2081 22-41 anti-HIV_cap256-059-006147_VR-Chain 2082 22-41 94-113 anti-HIV_cap256-059-005081_VR-Chain 2083 22-41 94-113 anti-HIV_cap256-059-005006_VR-Chain 2084 22-41 94-113 anti-HIV_cap256-059-004451_VR-Chain 2085 22-41 94-113 anti-HIV_cap256-059-003571_VR-Chain 2086 22-41 94-113 anti-HIV_cap256-059-003449_VR-Chain 2087 22-41 94-113 anti-HIV_cap256-059-002712_VR-Chain 2088 22-41 94-113 anti-HIV_cap256-059-001573_VR-Chain 2089 22-41 94-113 anti-HIV_cap256-059-001379_VR-Chain 2090 22-41 94-113 anti-HIV_cap256-059-001029_VR-Chain 2091 22-41 94-113 anti-HIV_cap256-048-165087_VR-Chain 2092 22-41 94-113 anti-HIV_cap256-048-158861_VR-Chain 2093 22-41 94-113 anti-HIV_cap256-048-158280_VR-Chain 2094 22-41 20-29 94-113 anti-HIV_cap256-048-157928_VR-Chain 2095 22-41 94-113 anti-HIV_cap256-048-157056_VR-Chain 2096 22-41 94-113 anti-HIV_cap256-048-156422_VR-Chain 2097 22-41 94-113 anti-HIV_cap256-048-152863_VR-Chain 2098 22-41 94-113 anti-HIV_cap256-048-152770_VR-Chain 2099 22-41 94-113 anti-HIV_cap256-048-150027_VR-Chain 2100 22-41 94-113 anti-HIV_cap256-048-148246_VR-Chain 2101 22-41 94-113 anti-HIV_cap256-048-147428_VR-Chain 2102 22-41 94-113 anti-HIV_cap256-048-146603_VR-Chain 2103 22-41 anti-HIV_cap256-048-145735_VR-Chain 2104 22-41 94-113 anti-HIV_cap256-048-145116_VR-Chain 2105 22-41 94-113 anti-HIV_cap256-048-144077_VR-Chain 2106 22-41 94-113 anti-HIV_cap256-048-142876_VR-Chain 2107 22-41 anti-HIV_cap256-048-140582_VR-Chain 2108 22-41 94-113 anti-HIV_cap256-048-139355_VR-Chain 2109 22-41 94-113 anti-HIV_cap256-048-139151_VR-Chain 2110 22-41 94-113 anti-HIV_cap256-048-137672_VR-Chain 2111 22-41 94-113 anti-HIV_cap256-048-137506_VR-Chain 2112 22-41 94-113 anti-HIV_cap256-048-137270_VR-Chain 2113 22-41 94-113 anti-HIV_cap256-048-135447_VR-Chain 2114 22-41 94-113 anti-HIV_cap256-048-131966_VR-Chain 2115 22-41 94-113 anti-HIV_cap256-048-131008_VR-Chain 2116 22-41 94-113 anti-HIV_cap256-048-129369_VR-Chain 2117 22-41 94-113 anti-HIV_cap256-048-128476_VR-Chain 2118 22-41 94-113 anti-HIV_cap256-048-128270_VR-Chain 2119 22-41 94-113 anti-HIV_cap256-048-126220_VR-Chain 2120 22-41 94-113 anti-HIV_cap256-048-125713_VR-Chain 2121 22-41 94-113 anti-HIV_cap256-048-123934_VR-Chain 2122 22-41 94-113 anti-HIV_cap256-048-122673_VR-Chain 2123 22-41 94-113 anti-HIV_cap256-048-122208_VR-Chain 2124 22-41 94-113 anti-HIV_cap256-048-121552_VR-Chain 2125 22-41 94-113 anti-HIV_cap256-048-120643_VR-Chain 2126 22-41 94-113 anti-HIV_cap256-048-118458_VR-Chain 2127 22-41 anti-HIV_cap256-048-118112_VR-Chain 2128 22-41 94-113 anti-HIV_cap256-048-116469_VR-Chain 2129 22-41 94-113 anti-HIV_cap256-048-113917_VR-Chain 2130 22-41 94-113 anti-HIV_cap256-048-112368_VR-Chain 2131 22-41 94-113 anti-HIV_cap256-048-112047_VR-Chain 2132 22-41 94-113 anti-HIV_cap256-048-112029_VR-Chain 2133 22-41 94-113 anti-HIV_cap256-048-110957_VR-Chain 2134 22-41 94-113 anti-HIV_cap256-048-110526_VR-Chain 2135 22-41 94-113 anti-HIV_cap256-048-109336_VR-Chain 2136 22-41 94-113 anti-HIV_cap256-048-108152_VR-Chain 2137 22-41 94-113 anti-HIV_cap256-048-107799_VR-Chain 2138 22-41 94-113 anti-HIV_cap256-048-107384_VR-Chain 2139 22-41 94-113 anti-HIV_cap256-048-106530_VR-Chain 2140 22-41 94-113 anti-HIV_cap256-048-106464_VR-Chain 2141 22-41 94-113 anti-HIV_cap256-048-106411_VR-Chain 2142 22-41 anti-HIV_cap256-048-106306_VR-Chain 2143 22-41 94-113 anti-HIV_cap256-048-104496_VR-Chain 2144 22-41 94-113 anti-HIV_cap256-048-103074_VR-Chain 2145 22-41 94-113 anti-HIV_cap256-048-100832_VR-Chain 2146 22-41 94-113 anti-HIV_cap256-048-100188_VR-Chain 2147 22-41 20-29 94-113 anti-HIV_cap256-048-099645_VR-Chain 2148 22-41 anti-HIV_cap256-048-098137_VR-Chain 2149 22-41 94-113 anti-HIV_cap256-048-097878_VR-Chain 2150 22-41 94-113 anti-HIV_cap256-048-097510_VR-Chain 2151 22-41 94-113 anti-HIV_cap256-048-097313_VR-Chain 2152 22-41 94-113 anti-HIV_cap256-048-096626_VR-Chain 2153 22-41 94-113 anti-HIV_cap256-048-096483_VR-Chain 2154 22-41 94-113 anti-HIV_cap256-048-095691_VR-Chain 2155 22-41 94-113 anti-HIV_cap256-048-095525_VR-Chain 2156 22-41 94-113 anti-HIV_cap256-048-094783_VR-Chain 2157 22-41 94-113 anti-HIV_cap256-048-094356_VR-Chain 2158 22-41 94-113 anti-HIV_cap256-048-090756_VR-Chain 2159 22-41 94-113 anti-HIV_cap256-048-089065_VR-Chain 2160 22-41 94-113 anti-HIV_cap256-048-084986_VR-Chain 2161 22-41 94-113 anti-HIV_cap256-048-083355_VR-Chain 2162 22-41 94-113 anti-HIV_cap256-048-082462_VR-Chain 2163 22-41 94-113 anti-HIV_cap256-048-082246_VR-Chain 2164 22-41 94-113 anti-HIV_cap256-048-080752_VR-Chain 2165 22-41 94-113 anti-HIV_cap256-048-078409_VR-Chain 2166 22-41 94-113 anti-HIV_cap256-048-078273_VR-Chain 2167 22-41 anti-HIV_cap256-048-078062_VR-Chain 2168 22-41 94-113 anti-HIV_cap256-048-077798_VR-Chain 2169 22-41 anti-HIV_cap256-048-073853_VR-Chain 2170 22-41 94-113 anti-HIV_cap256-048-071661_VR-Chain 2171 22-41 anti-HIV_cap256-048-071360_VR-Chain 2172 22-41 94-113 anti-HIV_cap256-048-070955_VR-Chain 2173 22-41 anti-HIV_cap256-048-070061_VR-Chain 2174 22-41 94-113 anti-HIV_cap256-048-069669_VR-Chain 2175 22-41 94-113 anti-HIV_cap256-048-069205_VR-Chain 2176 22-41 94-113 anti-HIV_cap256-048-068882_VR-Chain 2177 22-41 94-113 anti-HIV_cap256-048-067764_VR-Chain 2178 22-41 94-113 anti-HIV_cap256-048-066845_VR-Chain 2179 22-41 94-113 anti-HIV_cap256-048-065226_VR-Chain 2180 22-41 94-113 anti-HIV_cap256-048-063717_VR-Chain 2181 22-41 59-68 anti-HIV_cap256-048-063150_VR-Chain 2182 22-41 94-113 anti-HIV_cap256-048-062431_VR-Chain 2183 22-41 94-113 anti-HIV_cap256-048-060745_VR-Chain 2184 22-41 94-113 anti-HIV_cap256-048-060420_VR-Chain 2185 22-41 94-113 anti-HIV_cap256-048-060014_VR-Chain 2186 22-41  93-102 94-113 anti-HIV_cap256-048-059747_VR-Chain 2187 22-41 94-113 anti-HIV_cap256-048-058393_VR-Chain 2188 22-41 94-113 anti-HIV_cap256-048-058159_VR-Chain 2189 22-41 94-113 anti-HIV_cap256-048-057127_VR-Chain 2190 22-41 94-113 anti-HIV_cap256-048-056251_VR-Chain 2191 22-41 94-113 anti-HIV_cap256-048-055421_VR-Chain 2192 22-41 94-113 anti-HIV_cap256-048-054989_VR-Chain 2193 22-41 94-113 anti-HIV_cap256-048-054759_VR-Chain 2194 22-41 94-113 anti-HIV_cap256-048-052573_VR-Chain 2195 22-41 94-113 anti-HIV_cap256-048-051477_VR-Chain 2196 22-41 94-113 anti-HIV_cap256-048-051299_VR-Chain 2197 22-41 94-113 anti-HIV_cap256-048-050815_VR-Chain 2198 22-41 94-113 anti-HIV_cap256-048-049884_VR-Chain 2199 22-41 94-113 anti-HIV_cap256-048-049170_VR-Chain 2200 22-41 94-113 anti-HIV_cap256-048-048531_VR-Chain 2201 22-41 94-113 anti-HIV_cap256-048-048259_VR-Chain 2202 22-41 94-113 anti-HIV_cap256-048-047313_VR-Chain 2203 22-41 94-113 anti-HIV_cap256-048-046596_VR-Chain 2204 22-41 94-113 anti-HIV_cap256-048-044781_VR-Chain 2205 22-41 94-113 anti-HIV_cap256-048-042599_VR-Chain 2206 22-41 94-113 anti-HIV_cap256-048-041276_VR-Chain 2207 22-41 94-113 anti-HIV_cap256-048-040200_VR-Chain 2208 22-41 94-113 anti-HIV_cap256-048-039061_VR-Chain 2209 22-41  93-102 anti-HIV_cap256-048-038515_VR-Chain 2210 22-41 94-113 anti-HIV_cap256-048-038255_VR-Chain 2211 22-41 94-113 anti-HIV_cap256-048-038177_VR-Chain 2212 22-41  93-102 anti-HIV_cap256-048-035513_VR-Chain 2213 22-41 94-113 anti-HIV_cap256-048-034112_VR-Chain 2214 22-41 94-113 anti-HIV_cap256-048-033983_VR-Chain 2215 22-41 94-113 anti-HIV_cap256-048-032688_VR-Chain 2216 22-41 94-113 anti-HIV_cap256-048-031092_VR-Chain 2217 22-41 94-113 anti-HIV_cap256-048-030464_VR-Chain 2218 22-41 94-113 anti-HIV_cap256-048-030289_VR-Chain 2219 22-41 94-113 anti-HIV_cap256-048-030261_VR-Chain 2220 22-41 anti-HIV_cap256-048-029362_VR-Chain 2221 22-41 94-113 anti-HIV_cap256-048-027638_VR-Chain 2222 22-41 anti-HIV_cap256-048-027613_VR-Chain 2223 22-41 94-113 anti-HIV_cap256-048-026627_VR-Chain 2224 22-41 94-113 anti-HIV_cap256-048-026239_VR-Chain 2225 22-41 94-113 anti-HIV_cap256-048-025518_VR-Chain 2226 22-41 94-113 anti-HIV_cap256-048-024854_VR-Chain 2227 22-41 94-113 anti-HIV_cap256-048-024537_VR-Chain 2228 22-41 94-113 anti-HIV_cap256-048-021781_VR-Chain 2229 22-41 94-113 anti-HIV_cap256-048-021758_VR-Chain 2230 22-41 94-113 anti-HIV_cap256-048-020988_VR-Chain 2231 22-41 94-113 anti-HIV_cap256-048-020663_VR-Chain 2232 22-41 anti-HIV_cap256-048-020590_VR-Chain 2233 22-41 94-113 anti-HIV_cap256-048-019765_VR-Chain 2234 22-41 94-113 anti-HIV_cap256-048-019254_VR-Chain 2235 22-41 anti-HIV_cap256-048-018073_VR-Chain 2236 22-41 94-113 anti-HIV_cap256-048-016775_VR-Chain 2237 22-41 94-113 anti-HIV_cap256-048-016069_VR-Chain 2238 22-41 94-113 anti-HIV_cap256-048-015867_VR-Chain 2239 22-41 anti-HIV_cap256-048-015673_VR-Chain 2240 22-41 94-113 anti-HIV_cap256-048-015156_VR-Chain 2241 22-41 94-113 anti-HIV_cap256-048-014521_VR-Chain 2242 22-41 94-113 anti-HIV_cap256-048-014475_VR-Chain 2243 22-41 94-113 anti-HIV_cap256-048-013798_VR-Chain 2244 22-41 anti-HIV_cap256-048-013271_VR-Chain 2245 22-41 94-113 anti-HIV_cap256-048-013180_VR-Chain 2246 22-41 94-113 anti-HIV_cap256-048-012148_VR-Chain 2247 22-41 94-113 anti-HIV_cap256-048-011870_VR-Chain 2248 22-41 94-113 anti-HIV_cap256-048-011530_VR-Chain 2249 22-41 94-113 anti-HIV_cap256-048-010968_VR-Chain 2250 22-41 anti-HIV_cap256-048-010224_VR-Chain 2251 22-41 92-111 anti-HIV_cap256-048-009749_VR-Chain 2252 22-41 94-113 anti-HIV_cap256-048-009623_VR-Chain 2253 22-41 94-113 anti-HIV_cap256-048-008234_VR-Chain 2254 22-41 94-113 anti-HIV_cap256-048-008149_VR-Chain 2255 22-41 94-113 anti-HIV_cap256-048-007301_VR-Chain 2256 22-41 94-113 anti-HIV_cap256-048-007174_VR-Chain 2257 22-41 94-113 anti-HIV_cap256-048-007079_VR-Chain 2258 22-41 31-40 94-113 anti-HIV_cap256-048-007033_VR-Chain 2259 22-41 94-113 anti-HIV_cap256-048-006128_VR-Chain 2260 22-41 anti-HIV_cap256-048-005999_VR-Chain 2261 22-41 94-113 anti-HIV_cap256-048-005394_VR-Chain 2262 22-41 94-113 anti-HIV_cap256-048-004226_VR-Chain 2263 22-41 94-113 anti-HIV_cap256-048-004097_VR-Chain 2264 22-41 94-113 anti-HIV_cap256-048-003289_VR-Chain 2265 22-41 94-113 anti-HIV_cap256-048-002601_VR-Chain 2266 22-41 94-113 anti-HIV_cap256-048-002129_VR-Chain 2267 22-41 anti-HIV_cap256-048-001875_VR-Chain 2268 22-41 94-113 anti-HIV_cap256-048-001302_VR-Chain 2269 22-41 94-113 anti-HIV_cap256-048-001203_VR-Chain 2270 22-41 94-113 anti-HIV_cap256-048-000383_VR-Chain 2271 22-41 94-113 anti-HIV_cap256-038-261791_VR-Chain 2272 22-41 94-113 anti-HIV_cap256-038-241540_VR-Chain 2273 22-41 58-67 94-113 anti-HIV_cap256-038-235677_VR-Chain 2274 22-41 94-113 anti-HIV_cap256-038-234314_VR-Chain 2275 22-41 94-113 anti-HIV_cap256-038-234273_VR-Chain 2276 22-41 94-113 anti-HIV_cap256-038-223164_VR-Chain 2277 22-41 94-113 anti-HIV_cap256-038-220289_VR-Chain 2278 22-41 94-113 anti-HIV_cap256-038-220020_VR-Chain 2279 22-41 94-113 anti-HIV_cap256-038-216853_VR-Chain 2280 22-41 94-113 anti-HIV_cap256-038-213466_VR-Chain 2281 22-41 94-113 anti-HIV_cap256-038-213212_VR-Chain 2282 22-41 anti-HIV_cap256-038-213120_VR-Chain 2283 22-41 94-113 anti-HIV_cap256-038-212592_VR-Chain 2284 22-41 94-113 anti-HIV_cap256-038-211790_VR-Chain 2285 22-41 94-113 anti-HIV_cap256-038-209916_VR-Chain 2286 22-41 94-113 anti-HIV_cap256-038-207938_VR-Chain 2287 22-41 94-113 anti-HIV_cap256-038-202245_VR-Chain 2288 22-41 anti-HIV_cap256-038-197721_VR-Chain 2289 22-41 94-113 anti-HIV_cap256-038-196679_VR-Chain 2290 22-41 94-113 anti-HIV_cap256-038-196118_VR-Chain 2291 22-41 94-113 anti-HIV_cap256-038-195382_VR-Chain 2292 22-41 93-112 anti-HIV_cap256-038-180001_VR-Chain 2293 22-41 94-113 anti-HIV_cap256-038-178021_VR-Chain 2294 22-41 94-113 anti-HIV_cap256-038-177104_VR-Chain 2295 22-41 94-113 anti-HIV_cap256-038-171261_VR-Chain 2296 22-41 94-113 anti-HIV_cap256-038-169090_VR-Chain 2297 22-41 94-113 anti-HIV_cap256-038-168705_VR-Chain 2298 22-41 94-113 anti-HIV_cap256-038-167685_VR-Chain 2299 22-41 94-113 anti-HIV_cap256-038-158775_VR-Chain 2300 22-41 94-113 anti-HIV_cap256-038-157318_VR-Chain 2301 22-41 94-113 anti-HIV_cap256-038-153058_VR-Chain 2302 22-41 94-113 anti-HIV_cap256-038-150027_VR-Chain 2303 22-41 94-113 anti-HIV_cap256-038-146372_VR-Chain 2304 22-41 94-113 anti-HIV_cap256-038-141868_VR-Chain 2305 22-41 94-113 anti-HIV_cap256-038-141616_VR-Chain 2306 22-41 94-113 anti-HIV_cap256-038-127989_VR-Chain 2307 22-41 94-113 anti-HIV_cap256-038-118109_VR-Chain 2308 22-41 94-113 anti-HIV_cap256-038-112226_VR-Chain 2309 22-41 94-113 anti-HIV_cap256-038-105918_VR-Chain 2310 22-41 94-113 anti-HIV_cap256-038-104487_VR-Chain 2311 22-41 94-113 anti-HIV_cap256-038-102308_VR-Chain 2312 22-41 94-113 anti-HIV_cap256-038-091115_VR-Chain 2313 22-41 94-113 anti-HIV_cap256-038-090262_VR-Chain 2314 22-41 94-113 anti-HIV_cap256-038-083260_VR-Chain 2315 22-41 94-113 anti-HIV_cap256-038-080981_VR-Chain 2316 22-41 94-113 anti-HIV_cap256-038-080873_VR-Chain 2317 22-41 94-113 anti-HIV_cap256-038-074413_VR-Chain 2318 22-41 94-113 anti-HIV_cap256-038-073153_VR-Chain 2319 22-41 94-113 anti-HIV_cap256-038-064227_VR-Chain 2320 22-41 94-113 anti-HIV_cap256-038-061640_VR-Chain 2321 22-41 94-113 anti-HIV_cap256-038-059482_VR-Chain 2322 22-41 88-107 anti-HIV_cap256-038-054000_VR-Chain 2323 22-41 94-113 anti-HIV_cap256-038-050554_VR-Chain 2324 22-41 94-113 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49-58 87-106 anti-HIV_206-072383_VR-Chain 2344 22-41 49-58 anti-HIV_206-037527_VR-Chain 2345 22-41 49-58 anti-HIV_206-009095_VR-Chain 2346 22-41 49-58 anti-HIV_176-503620_VR-Chain 2347 22-41 49-58 87-106 anti-HIV_176-478726_VR-Chain 2348 22-41 49-58 87-106 anti-HIV_176-245056_VR-Chain 2349 22-41 49-58 87-106 anti-HIV_176-164413_VR-Chain 2350 22-41 49-58 87-106 anti-HIV_176-094308_VR-Chain 2351 22-41 anti-HIV_176-065321_VR-Chain 2352 22-41 87-106 anti-HIV_119-099719_VR-Chain 2353 22-41 49-58 87-106 anti-HIV_119-099536_VR-Chain 2354 22-41 47-56 85-104 anti-HIV_119-098907_VR-Chain 2355 22-41 87-106 anti-HIV_119-098555_VR-Chain 2356 22-41 49-58 87-106 anti-HIV_119-097828_VR-Chain 2357 22-41 49-58 87-106 anti-HIV_119-096480_VR-Chain 2358 22-41 87-106 anti-HIV_119-095664_VR-Chain 2359 22-41 49-58 87-106 anti-HIV_119-095212_VR-Chain 2360 22-41 anti-HIV_119-094773_VR-Chain 2361 22-41 49-58 anti-HIV_119-094508_VR-Chain 2362 22-41 87-106 anti-HIV_119-093795_VR-Chain 2363 22-41 87-106 anti-HIV_119-093732_VR-Chain 2364 22-41 49-58 anti-HIV_119-092903_VR-Chain 2365 22-41 49-58 87-106 anti-HIV_119-092284_VR-Chain 2366 22-41 anti-HIV_119-091586_VR-Chain 2367 22-41 49-58 anti-HIV_119-091023_VR-Chain 2368 22-41 49-58 anti-HIV_119-090334_VR-Chain 2369 22-41 87-106 anti-HIV_119-088694_VR-Chain 2370 22-41 87-106 anti-HIV_119-088499_VR-Chain 2371 22-41 49-58 87-106 anti-HIV_119-088298_VR-Chain 2372 22-41 49-58 anti-HIV_119-087488_VR-Chain 2373 22-41 87-106 anti-HIV_119-087423_VR-Chain 2374 22-41 49-58 87-106 anti-HIV_119-087371_VR-Chain 2375 22-41 49-58 87-106 anti-HIV_119-087279_VR-Chain 2376 22-41 87-106 anti-HIV_119-087146_VR-Chain 2377 22-41 49-58 87-106 anti-HIV_119-087048_VR-Chain 2378 22-41 49-58 87-106 anti-HIV_119-085802_VR-Chain 2379 22-41 anti-HIV_119-085784_VR-Chain 2380 22-41 49-58 87-106 anti-HIV_119-085370_VR-Chain 2381 22-41 49-58 87-106 anti-HIV_119-085276_VR-Chain 2382 22-41 49-58 anti-HIV_119-084885_VR-Chain 2383 22-41 87-106 anti-HIV_119-084874_VR-Chain 2384 22-41 49-58 anti-HIV_119-084691_VR-Chain 2385 22-41 49-58 anti-HIV_119-083793_VR-Chain 2386 22-41 49-58 87-106 anti-HIV_119-083163_VR-Chain 2387 22-41 87-106 anti-HIV_119-082331_VR-Chain 2388 22-41 49-58 anti-HIV_119-082070_VR-Chain 2389 22-41 49-58 87-106 anti-HIV_119-081512_VR-Chain 2390 22-41 49-58 anti-HIV_119-080816_VR-Chain 2391 22-41 49-58 87-106 anti-HIV_119-079302_VR-Chain 2392 22-41 49-58 anti-HIV_119-079292_VR-Chain 2393 22-41 49-58 87-106 anti-HIV_119-079289_VR-Chain 2394 22-41 49-58 anti-HIV_119-078935_VR-Chain 2395 22-41 49-58 87-106 anti-HIV_119-078702_VR-Chain 2396 22-41 49-58 87-106 anti-HIV_119-078593_VR-Chain 2397 22-41 49-58 87-106 anti-HIV_119-077708_VR-Chain 2398 22-41 49-58 87-106 anti-HIV_119-076904_VR-Chain 2399 22-41 49-58 anti-HIV_119-075862_VR-Chain 2400 22-41 49-58 87-106 anti-HIV_119-075465_VR-Chain 2401 22-41 49-58 anti-HIV_119-074822_VR-Chain 2402 22-41 48-57 86-105 anti-HIV_119-074629_VR-Chain 2403 22-41 49-58 anti-HIV_119-074500_VR-Chain 2404 22-41 49-58 87-106 anti-HIV_119-073911_VR-Chain 2405 22-41 87-106 anti-HIV_119-072765_VR-Chain 2406 22-41 87-106 anti-HIV_119-072313_VR-Chain 2407 22-41 49-58 87-106 anti-HIV_119-072280_VR-Chain 2408 22-41 87-106 anti-HIV_119-071693_VR-Chain 2409 22-41 49-58 87-106 anti-HIV_119-071353_VR-Chain 2410 22-41 anti-HIV_119-069711_VR-Chain 2411 22-41 49-58 87-106 anti-HIV_119-069061_VR-Chain 2412 22-41 87-106 anti-HIV_119-068202_VR-Chain 2413 22-41 49-58 87-106 anti-HIV_119-068063_VR-Chain 2414 22-41 87-106 anti-HIV_119-067980_VR-Chain 2415 22-41 anti-HIV_119-067866_VR-Chain 2416 22-41 49-58 87-106 anti-HIV_119-067756_VR-Chain 2417 22-41 49-58 anti-HIV_119-066859_VR-Chain 2418 22-41 49-58 anti-HIV_119-065821_VR-Chain 2419 22-41 49-58 87-106 anti-HIV_119-065191_VR-Chain 2420 22-41 87-106 anti-HIV_119-064667_VR-Chain 2421 22-41 49-58 anti-HIV_119-063791_VR-Chain 2422 22-41 49-58 87-106 anti-HIV_119-062989_VR-Chain 2423 22-41 49-58 87-106 anti-HIV_119-062286_VR-Chain 2424 22-41 87-106 anti-HIV_119-061416_VR-Chain 2425 22-41 49-58 anti-HIV_119-061344_VR-Chain 2426 22-41 49-58 87-106 anti-HIV_119-060240_VR-Chain 2427 22-41 87-106 anti-HIV_119-060184_VR-Chain 2428 22-41 49-58 anti-HIV_119-058035_VR-Chain 2429 22-41 49-58 anti-HIV_119-057858_VR-Chain 2430 22-41 49-58 anti-HIV_119-057473_VR-Chain 2431 22-41 49-58 87-106 anti-HIV_119-057090_VR-Chain 2432 22-41 anti-HIV_119-055754_VR-Chain 2433 22-41 anti-HIV_119-054899_VR-Chain 2434 22-41 87-106 anti-HIV_119-054501_VR-Chain 2435 22-41 87-106 anti-HIV_119-051867_VR-Chain 2436 22-41 49-58 87-106 anti-HIV_119-051814_VR-Chain 2437 22-41 49-58 87-106 anti-HIV_119-051567_VR-Chain 2438 22-41 20-29 anti-HIV_119-051483_VR-Chain 2439 22-41 49-58 87-106 anti-HIV_119-050913_VR-Chain 2440 22-41 49-58 87-106 anti-HIV_119-050187_VR-Chain 2441 22-41 49-58 anti-HIV_119-049069_VR-Chain 2442 22-41 87-106 anti-HIV_119-048517_VR-Chain 2443 22-41 49-58 anti-HIV_119-048470_VR-Chain 2444 22-41 49-58 anti-HIV_119-048303_VR-Chain 2445 22-41 48-57 86-94 anti-HIV_119-048021_VR-Chain 2446 22-41 49-58 anti-HIV_119-047928_VR-Chain 2447 22-41 49-58 87-106 anti-HIV_119-047384_VR-Chain 2448 22-41 49-58 87-106 anti-HIV_119-047145_VR-Chain 2449 22-41 49-58 87-106 anti-HIV_119-046752_VR-Chain 2450 22-41 87-106 anti-HIV_119-046660_VR-Chain 2451 22-41 49-58 87-106 anti-HIV_119-046202_VR-Chain 2452 22-41 anti-HIV_119-045790_VR-Chain 2453 22-41 87-106 anti-HIV_119-044670_VR-Chain 2454 22-41 49-58 87-106 anti-HIV_119-044140_VR-Chain 2455 22-41 49-58 87-106 anti-HIV_119-042776_VR-Chain 2456 22-41 49-58 87-106 anti-HIV_119-042581_VR-Chain 2457 22-41 87-106 anti-HIV_119-040905_VR-Chain 2458 22-41 anti-HIV_119-040322_VR-Chain 2459 22-41 49-58 anti-HIV_119-039892_VR-Chain 2460 22-41 49-58 87-106 anti-HIV_119-039764_VR-Chain 2461 22-41 49-58 87-106 anti-HIV_119-039188_VR-Chain 2462 22-41 49-58 anti-HIV_119-039058_VR-Chain 2463 22-41 49-58 anti-HIV_119-038837_VR-Chain 2464 22-41 87-106 anti-HIV_119-038396_VR-Chain 2465 22-41 87-106 anti-HIV_119-036918_VR-Chain 2466 22-41 49-58 87-106 anti-HIV_119-036592_VR-Chain 2467 22-41 49-58 87-106 anti-HIV_119-036310_VR-Chain 2468 22-41 49-58 87-106 anti-HIV_119-035618_VR-Chain 2469 22-41 87-106 anti-HIV_119-035569_VR-Chain 2470 22-41 49-58 87-106 anti-HIV_119-035466_VR-Chain 2471 22-41 49-58 87-106 anti-HIV_119-035157_VR-Chain 2472 22-41 49-58 87-106 anti-HIV_119-035121_VR-Chain 2473 22-41 49-58 anti-HIV_119-035046_VR-Chain 2474 22-41 49-58 87-106 anti-HIV_119-034754_VR-Chain 2475 22-41 49-58 87-106 anti-HIV_119-034318_VR-Chain 2476 22-41 49-58 87-106 anti-HIV_119-033780_VR-Chain 2477 22-41 49-58 anti-HIV_119-033632_VR-Chain 2478 22-41 49-58 87-106 anti-HIV_119-033183_VR-Chain 2479 22-41 49-58 87-106 anti-HIV_119-030696_VR-Chain 2480 22-41 49-58 anti-HIV_119-030059_VR-Chain 2481 22-41 49-58 87-106 anti-HIV_119-029589_VR-Chain 2482 22-41 49-58 anti-HIV_119-029448_VR-Chain 2483 22-41 49-58 87-106 anti-HIV_119-029220_VR-Chain 2484 22-41 49-58 anti-HIV_119-028317_VR-Chain 2485 22-41 49-58 87-106 anti-HIV_119-028165_VR-Chain 2486 22-41 87-106 anti-HIV_119-027147_VR-Chain 2487 22-41 87-106 anti-HIV_119-026743_VR-Chain 2488 22-41 49-58 87-106 anti-HIV_119-026508_VR-Chain 2489 22-41 87-106 anti-HIV_119-025683_VR-Chain 2490 22-41 49-58 87-106 anti-HIV_119-025614_VR-Chain 2491 22-41 87-106 anti-HIV_119-025548_VR-Chain 2492 22-41 49-58 87-106 anti-HIV_119-025526_VR-Chain 2493 22-41 49-58 87-106 anti-HIV_119-023552_VR-Chain 2494 22-41 87-106 anti-HIV_119-023092_VR-Chain 2495 22-41 anti-HIV_119-022793_VR-Chain 2496 22-41 49-58 87-106 anti-HIV_119-022395_VR-Chain 2497 22-41 87-106 anti-HIV_119-022334_VR-Chain 2498 22-41 49-58 87-106 anti-HIV_119-021866_VR-Chain 2499 22-41 49-58 anti-HIV_119-021278_VR-Chain 2500 22-41 49-58 87-106 anti-HIV_119-021183_VR-Chain 2501 22-41 87-106 anti-HIV_119-019376_VR-Chain 2502 22-41 87-106 anti-HIV_119-019238_VR-Chain 2503 22-41 49-58 anti-HIV_119-018500_VR-Chain 2504 22-41 49-58 87-106 anti-HIV_119-018318_VR-Chain 2505 22-41 87-106 anti-HIV_119-018218_VR-Chain 2506 22-41 49-58 anti-HIV_119-017876_VR-Chain 2507 22-41 49-58 87-106 anti-HIV_119-017740_VR-Chain 2508 22-41 49-58 87-106 anti-HIV_119-017128_VR-Chain 2509 22-41 49-58 anti-HIV_119-017044_VR-Chain 2510 22-41 49-58 87-106 anti-HIV_119-016644_VR-Chain 2511 22-41 49-58 87-106 anti-HIV_119-015878_VR-Chain 2512 22-41 49-58 87-106 anti-HIV_119-015538_VR-Chain 2513 22-41 49-58 87-106 anti-HIV_119-015455_VR-Chain 2514 22-41 49-58 87-106 anti-HIV_119-014425_VR-Chain 2515 22-41 49-58 87-106 anti-HIV_119-013582_VR-Chain 2516 22-41 87-106 anti-HIV_119-013364_VR-Chain 2517 22-41 49-58 87-106 anti-HIV_119-012886_VR-Chain 2518 22-41 87-106 anti-HIV_119-012249_VR-Chain 2519 22-41 49-58 anti-HIV_119-012161_VR-Chain 2520 22-41 49-58 87-106 anti-HIV_119-012110_VR-Chain 2521 22-41 87-106 anti-HIV_119-012100_VR-Chain 2522 22-41 49-58 87-106 anti-HIV_119-011651_VR-Chain 2523 22-41 49-58 87-106 anti-HIV_119-011479_VR-Chain 2524 22-41 49-58 87-106 anti-HIV_119-011232_VR-Chain 2525 22-41 49-58 anti-HIV_119-011175_VR-Chain 2526 22-41 49-58 anti-HIV_119-008396_VR-Chain 2527 22-41 87-106 anti-HIV_119-007148_VR-Chain 2528 22-41 87-106 anti-HIV_119-007029_VR-Chain 2529 22-41 87-106 anti-HIV_119-004707_VR-Chain 2530 22-41 87-106 anti-HIV_119-003910_VR-Chain 2531 22-41 87-106 anti-HIV_119-002450_VR-Chain 2532 22-41 49-58 87-106 anti-HIV_119-001552_VR-Chain 2533 22-41 49-58 87-106 anti-HIV_059-188169_VR-Chain 2534 22-41 49-58 87-106 anti-HIV_059-183739_VR-Chain 2535 22-41 49-58 87-106 anti-HIV_059-182376_VR-Chain 2536 22-41 49-58 87-106 anti-HIV_059-182199_VR-Chain 2537 22-41 49-58 87-106 anti-HIV_059-169202_VR-Chain 2538 22-41 49-58 87-106 anti-HIV_059-155645_VR-Chain 2539 22-41 49-58 87-106 anti-HIV_059-151619_VR-Chain 2540 22-41 87-106 anti-HIV_059-146503_VR-Chain 2541 22-41 49-58 87-106 anti-HIV_059-136098_VR-Chain 2542 22-41 49-58 87-106 anti-HIV_059-105516_VR-Chain 2543 22-41 49-58 87-106 anti-HIV_059-095709_VR-Chain 2544 22-41 49-58 87-106 anti-HIV_059-069468_VR-Chain 2545 22-41 49-58 87-106 anti-HIV_059-060026_VR-Chain 2546 22-41 49-58 87-106 anti-HIV_059-053668_VR-Chain 2547 22-41 49-58 87-106 anti-HIV_059-052864_VR-Chain 2548 22-41 49-58 87-106 anti-HIV_059-050968_VR-Chain 2549 22-41 49-58 87-106 anti-HIV_059-046422_VR-Chain 2550 22-41 87-106 anti-HIV_059-045120_VR-Chain 2551 22-41 87-106 anti-HIV_059-039932_VR-Chain 2552 22-41 49-58 87-106 anti-HIV_059-038595_VR-Chain 2553 22-41 49-58 87-106 anti-HIV_059-035082_VR-Chain 2554 22-41 49-58 87-106 anti-HIV_059-029204_VR-Chain 2555 22-41 49-58 87-106 anti-HIV_059-025235_VR-Chain 2556 22-41 49-58 87-106 anti-HIV_059-015192_VR-Chain 2557 22-41 49-58 87-106 anti-HIV_059-007060_VR-Chain 2558 22-41 49-58 anti-HIV_059-006953_VR-Chain 2559 22-41 46-55 84-103 anti-HIV_059-005953_VR-Chain 2560 22-41 49-58 87-106 anti-HIV_059-003725_VR-Chain 2561 22-41 87-106 anti-HIV_059-002618_VR-Chain 2562 22-41 49-58 87-106 anti-HIV_059-001522_VR-Chain 2563 22-41 49-58 87-106 anti-HIV_059-000731_VR-Chain 2564 22-41 49-58 87-106 anti-HIV_059-000634_VR-Chain 2565 22-41 49-58 87-106 anti-HIV_048-250757_VR-Chain 2566 22-41 49-58 87-106 anti-HIV_048-250716_VR-Chain 2567 22-41 49-58 87-106 anti-HIV_048-250463_VR-Chain 2568 22-41 49-58 87-106 anti-HIV_048-248153_VR-Chain 2569 22-41 49-58 87-106 anti-HIV_048-247532_VR-Chain 2570 22-41 49-58 87-106 anti-HIV_048-245846_VR-Chain 2571 22-41 49-58 87-106 anti-HIV_048-244016_VR-Chain 2572 22-41 49-58 87-106 anti-HIV_048-243682_VR-Chain 2573 22-41 49-58 87-106 anti-HIV_048-243588_VR-Chain 2574 22-41 49-58 87-106 anti-HIV_048-241775_VR-Chain 2575 22-41 49-58 87-106 anti-HIV_048-237996_VR-Chain 2576 22-41 49-58 87-106 anti-HIV_048-237730_VR-Chain 2577 22-41 48-57 86-105 anti-HIV_048-237253_VR-Chain 2578 22-41 49-58 87-106 anti-HIV_048-234100_VR-Chain 2579 22-41 49-58 87-106 anti-HIV_048-230882_VR-Chain 2580 22-41 49-58 87-106 anti-HIV_048-229473_VR-Chain 2581 22-41 49-58 87-106 anti-HIV_048-228238_VR-Chain 2582 22-41 49-58 87-106 anti-HIV_048-228027_VR-Chain 2583 22-41 49-58 87-106 anti-HIV_048-227795_VR-Chain 2584 22-41 49-58 87-106 anti-HIV_048-227770_VR-Chain 2585 22-41 49-58 87-106 anti-HIV_048-225298_VR-Chain 2586 22-41 49-58 87-106 anti-HIV_048-225090_VR-Chain 2587 22-41 47-56 85-104 anti-HIV_048-224187_VR-Chain 2588 22-41 87-106 anti-HIV_048-223055_VR-Chain 2589 22-41 49-58 87-106 anti-HIV_048-222711_VR-Chain 2590 22-41 87-106 anti-HIV_048-221209_VR-Chain 2591 22-41 87-106 anti-HIV_048-220629_VR-Chain 2592 22-41 49-58 87-106 anti-HIV_048-219430_VR-Chain 2593 22-41 49-58 87-106 anti-HIV_048-216250_VR-Chain 2594 22-41 87-106 anti-HIV_048-216133_VR-Chain 2595 22-41 45-54 83-102 anti-HIV_048-214886_VR-Chain 2596 22-41 49-58 87-106 anti-HIV_048-214709_VR-Chain 2597 22-41 49-58 87-106 anti-HIV_048-214001_VR-Chain 2598 22-41 49-58 87-106 anti-HIV_048-213230_VR-Chain 2599 22-41 49-58 87-106 anti-HIV_048-212574_VR-Chain 2600 22-41 49-58 87-106 anti-HIV_048-212207_VR-Chain 2601 22-41 49-58 87-106 anti-HIV_048-209146_VR-Chain 2602 22-41 87-106 anti-HIV_048-208206_VR-Chain 2603 22-41 49-58 87-106 anti-HIV_048-208194_VR-Chain 2604 22-41 87-106 anti-HIV_048-207744_VR-Chain 2605 22-41 49-58 87-106 anti-HIV_048-206501_VR-Chain 2606 22-41 49-58 87-106 anti-HIV_048-204221_VR-Chain 2607 22-41 49-58 87-106 anti-HIV_048-204015_VR-Chain 2608 22-41 49-58 87-106 anti-HIV_048-201240_VR-Chain 2609 22-41 87-106 anti-HIV_048-200455_VR-Chain 2610 22-41 49-58 87-106 anti-HIV_048-200319_VR-Chain 2611 22-41 49-58 87-106 anti-HIV_048-197896_VR-Chain 2612 22-41 87-106 anti-HIV_048-193813_VR-Chain 2613 22-41 49-58 87-106 anti-HIV_048-192098_VR-Chain 2614 22-41 49-58 87-106 anti-HIV_048-191786_VR-Chain 2615 22-41 49-58 87-106 anti-HIV_048-188746_VR-Chain 2616 22-41 49-58 87-106 anti-HIV_048-185937_VR-Chain 2617 22-41 49-58 87-106 anti-HIV_048-184849_VR-Chain 2618 22-41 49-58 87-106 anti-HIV_048-183089_VR-Chain 2619 22-41 87-106 anti-HIV_048-181509_VR-Chain 2620 22-41 49-58 87-106 anti-HIV_048-180990_VR-Chain 2621 22-41 87-106 anti-HIV_048-177532_VR-Chain 2622 22-41 87-106 anti-HIV_048-177426_VR-Chain 2623 22-41 46-55 84-103 anti-HIV_048-177389_VR-Chain 2624 22-41 49-58 87-106 anti-HIV_048-174266_VR-Chain 2625 22-41 49-58 87-106 anti-HIV_048-172847_VR-Chain 2626 22-41 49-58 87-106 anti-HIV_048-172845_VR-Chain 2627 22-41 49-58 87-106 anti-HIV_048-172363_VR-Chain 2628 22-41 87-106 anti-HIV_048-171609_VR-Chain 2629 22-41 49-58 87-106 anti-HIV_048-170705_VR-Chain 2630 22-41 49-58 87-106 anti-HIV_048-168381_VR-Chain 2631 22-41 49-58 87-106 anti-HIV_048-166619_VR-Chain 2632 22-41 49-58 87-106 anti-HIV_048-162036_VR-Chain 2633 22-41 49-58 87-106 anti-HIV_048-160042_VR-Chain 2634 22-41 49-58 87-106 anti-HIV_048-159676_VR-Chain 2635 22-41 49-58 87-106 anti-HIV_048-159500_VR-Chain 2636 22-41 49-58 87-106 anti-HIV_048-159421_VR-Chain 2637 22-41 49-58 87-106 anti-HIV_048-159333_VR-Chain 2638 22-41 49-58 87-106 anti-HIV_048-158932_VR-Chain 2639 22-41 49-58 87-106 anti-HIV_048-155811_VR-Chain 2640 22-41 87-106 anti-HIV_048-155464_VR-Chain 2641 22-41 49-58 87-106 anti-HIV_048-155392_VR-Chain 2642 22-41 87-106 anti-HIV_048-155389_VR-Chain 2643 22-41 49-58 87-106 anti-HIV_048-154449_VR-Chain 2644 22-41 49-58 87-106 anti-HIV_048-153379_VR-Chain 2645 22-41 49-58 87-106 anti-HIV_048-153171_VR-Chain 2646 22-41 32-41 87-106 anti-HIV_048-152324_VR-Chain 2647 22-41 49-58 87-106 anti-HIV_048-146102_VR-Chain 2648 22-41 49-58 87-106 anti-HIV_048-145984_VR-Chain 2649 22-41 87-106 anti-HIV_048-145371_VR-Chain 2650 22-41 49-58 87-106 anti-HIV_048-144907_VR-Chain 2651 22-41 49-58 87-106 anti-HIV_048-142298_VR-Chain 2652 22-41 87-106 anti-HIV_048-142277_VR-Chain 2653 22-41 49-58 87-106 anti-HIV_048-141934_VR-Chain 2654 22-41 49-58 87-106 anti-HIV_048-141207_VR-Chain 2655 22-41 49-58 87-106 anti-HIV_048-140796_VR-Chain 2656 22-41 49-58 87-106 anti-HIV_048-139893_VR-Chain 2657 22-41 49-58 87-106 anti-HIV_048-138820_VR-Chain 2658 22-41 49-58 87-106 anti-HIV_048-135858_VR-Chain 2659 22-41 49-58 87-106 anti-HIV_048-134968_VR-Chain 2660 22-41 49-58 87-106 anti-HIV_048-134312_VR-Chain 2661 22-41 49-58 87-106 anti-HIV_048-132253_VR-Chain 2662 22-41 48-57 86-105 anti-HIV_048-130710_VR-Chain 2663 22-41 87-106 anti-HIV_048-128564_VR-Chain 2664 22-41 49-58 87-106 anti-HIV_048-126702_VR-Chain 2665 22-41 49-58 87-106 anti-HIV_048-124521_VR-Chain 2666 22-41 49-58 87-106 anti-HIV_048-122740_VR-Chain 2667 22-41 87-106 anti-HIV_048-119536_VR-Chain 2668 22-41 47-56 85-104 anti-HIV_048-116929_VR-Chain 2669 22-41 49-58 87-106 anti-HIV_048-116577_VR-Chain 2670 22-41 49-58 87-106 anti-HIV_048-116046_VR-Chain 2671 22-41 49-58 87-106 anti-HIV_048-115875_VR-Chain 2672 22-41 49-58 87-106 anti-HIV_048-115599_VR-Chain 2673 22-41 87-106 anti-HIV_048-113988_VR-Chain 2674 22-41 87-106 anti-HIV_048-112989_VR-Chain 2675 22-41 49-58 87-106 anti-HIV_048-112435_VR-Chain 2676 22-41 87-106 anti-HIV_048-111339_VR-Chain 2677 22-41 49-58 87-106 anti-HIV_048-111055_VR-Chain 2678 22-41 49-58 87-106 anti-HIV_048-111027_VR-Chain 2679 22-41 49-58 87-106 anti-HIV_048-109721_VR-Chain 2680 22-41 49-58 87-106 anti-HIV_048-109666_VR-Chain 2681 22-41 49-58 87-106 anti-HIV_048-109196_VR-Chain 2682 22-41 49-58 87-106 anti-HIV_048-109051_VR-Chain 2683 22-41 87-106 anti-HIV_048-108570_VR-Chain 2684 22-41 49-58 87-106 anti-HIV_048-108033_VR-Chain 2685 22-41 47-56 85-104 anti-HIV_048-107279_VR-Chain 2686 22-41 49-58 87-106 anti-HIV_048-106271_VR-Chain 2687 22-41 49-58 87-106 anti-HIV_048-106054_VR-Chain 2688 22-41 49-58 87-106 anti-HIV_048-104848_VR-Chain 2689 22-41 87-106 anti-HIV_048-104638_VR-Chain 2690 22-41 49-58 87-106 anti-HIV_048-104567_VR-Chain 2691 22-41 49-58 87-106 anti-HIV_048-102804_VR-Chain 2692 22-41 49-58 87-106 anti-HIV_048-101676_VR-Chain 2693 22-41 87-106 anti-HIV_048-097603_VR-Chain 2694 22-41 49-58 87-106 anti-HIV_048-097107_VR-Chain 2695 22-41 49-58 87-106 anti-HIV_048-096871_VR-Chain 2696 22-41 49-58 87-106 anti-HIV_048-096668_VR-Chain 2697 22-41 49-58 87-106 anti-HIV_048-095236_VR-Chain 2698 22-41 49-58 87-106 anti-HIV_048-094155_VR-Chain 2699 22-41 49-58 87-106 anti-HIV_048-093219_VR-Chain 2700 22-41 49-58 87-106 anti-HIV_048-092976_VR-Chain 2701 22-41 49-58 87-106 anti-HIV_048-090866_VR-Chain 2702 22-41 49-58 87-106 anti-HIV_048-090650_VR-Chain 2703 22-41 87-106 anti-HIV_048-089009_VR-Chain 2704 22-41 49-58 87-106 anti-HIV_048-088654_VR-Chain 2705 22-41 49-58 87-106 anti-HIV_048-086513_VR-Chain 2706 22-41 49-58 87-106 anti-HIV_048-086024_VR-Chain 2707 22-41 46-55 84-103 anti-HIV_048-085857_VR-Chain 2708 22-41 49-58 87-106 anti-HIV_048-084277_VR-Chain 2709 22-41 49-58 87-106 anti-HIV_048-084245_VR-Chain 2710 22-41 49-58 87-106 anti-HIV_048-082487_VR-Chain 2711 22-41 87-106 anti-HIV_048-081787_VR-Chain 2712 22-41 49-58 87-106 anti-HIV_048-081062_VR-Chain 2713 22-41 49-58 87-106 anti-HIV_048-079639_VR-Chain 2714 22-41 49-58 87-106 anti-HIV_048-079126_VR-Chain 2715 22-41 87-106 anti-HIV_048-073118_VR-Chain 2716 22-41 49-58 87-106 anti-HIV_048-070264_VR-Chain 2717 22-41 49-58 87-106 anti-HIV_048-069426_VR-Chain 2718 22-41 49-58 87-106 anti-HIV_048-068564_VR-Chain 2719 22-41 49-58 87-106 anti-HIV_048-068345_VR-Chain 2720 22-41 49-58 87-106 anti-HIV_048-067337_VR-Chain 2721 22-41 49-58 87-106 anti-HIV_048-067180_VR-Chain 2722 22-41 49-58 87-106 anti-HIV_048-063017_VR-Chain 2723 22-41 49-58 87-106 anti-HIV_048-061885_VR-Chain 2724 22-41 49-58 87-106 anti-HIV_048-061671_VR-Chain 2725 22-41 49-58 87-106 anti-HIV_048-060700_VR-Chain 2726 22-41 49-58 87-106 anti-HIV_048-060592_VR-Chain 2727 22-41 49-58 87-106 anti-HIV_048-060300_VR-Chain 2728 22-41 49-58 87-106 anti-HIV_048-059141_VR-Chain 2729 22-41 49-58 87-106 anti-HIV_048-057777_VR-Chain 2730 22-41 49-58 87-106 anti-HIV_048-056928_VR-Chain 2731 22-41 49-58 87-106 anti-HIV_048-056131_VR-Chain 2732 22-41 49-58 87-106 anti-HIV_048-055864_VR-Chain 2733 22-41 20-29 87-106 anti-HIV_048-055094_VR-Chain 2734 22-41 87-106 anti-HIV_048-054343_VR-Chain 2735 22-41 87-106 anti-HIV_048-054193_VR-Chain 2736 22-41 87-106 anti-HIV_048-052521_VR-Chain 2737 22-41 49-58 87-106 anti-HIV_048-049037_VR-Chain 2738 22-41 49-58 87-106 anti-HIV_048-048720_VR-Chain 2739 22-41 49-58 87-106 anti-HIV_048-048542_VR-Chain 2740 22-41 49-58 87-106 anti-HIV_048-047777_VR-Chain 2741 22-41 49-58 87-106 anti-HIV_048-046841_VR-Chain 2742 22-41 49-58 87-106 anti-HIV_048-046202_VR-Chain 2743 22-41 49-58 87-106 anti-HIV_048-046059_VR-Chain 2744 22-41 49-58 87-106 anti-HIV_048-043568_VR-Chain 2745 22-41 49-58 87-106 anti-HIV_048-042713_VR-Chain 2746 22-41 49-58 87-106 anti-HIV_048-042440_VR-Chain 2747 22-41 49-58 87-106 anti-HIV_048-040511_VR-Chain 2748 22-41 49-58 87-106 anti-HIV_048-039195_VR-Chain 2749 22-41 49-58 87-106 anti-HIV_048-036935_VR-Chain 2750 22-41 49-58 87-106 anti-HIV_048-034478_VR-Chain 2751 22-41 49-58 87-106 anti-HIV_048-031641_VR-Chain 2752 22-41 49-58 87-106 anti-HIV_048-029760_VR-Chain 2753 22-41 49-58 87-106 anti-HIV_048-027970_VR-Chain 2754 22-41 49-58 87-106 anti-HIV_048-027337_VR-Chain 2755 22-41 49-58 87-106 anti-HIV_048-027217_VR-Chain 2756 22-41 49-58 87-106 anti-HIV_048-026760_VR-Chain 2757 22-41 49-58 87-106 anti-HIV_048-024800_VR-Chain 2758 22-41 49-58 87-106 anti-HIV_048-024313_VR-Chain 2759 22-41 49-58 87-106 anti-HIV_048-021748_VR-Chain 2760 22-41 49-58 87-106 anti-HIV_048-020991_VR-Chain 2761 22-41 49-58 87-106 anti-HIV_048-020340_VR-Chain 2762 22-41 49-58 87-106 anti-HIV_048-019993_VR-Chain 2763 22-41 49-58 87-106 anti-HIV_048-019947_VR-Chain 2764 22-41 49-58 87-106 anti-HIV_048-017871_VR-Chain 2765 22-41 49-58 87-106 anti-HIV_048-015931_VR-Chain 2766 22-41 49-58 87-106 anti-HIV_048-015920_VR-Chain 2767 22-41 49-58 87-106 anti-HIV_048-013898_VR-Chain 2768 22-41 49-58 87-106 anti-HIV_048-013429_VR-Chain 2769 22-41 49-58 87-106 anti-HIV_048-012358_VR-Chain 2770 22-41 49-58 87-106 anti-HIV_048-011158_VR-Chain 2771 22-41 49-58 87-106 anti-HIV_048-010720_VR-Chain 2772 22-41 49-58 87-106 anti-HIV_048-009445_VR-Chain 2773 22-41 49-58 87-106 anti-HIV_048-006126_VR-Chain 2774 22-41 46-55 84-103 anti-HIV_048-005652_VR-Chain 2775 22-41 49-58 87-106 anti-HIV_048-005532_VR-Chain 2776 22-41 49-58 87-106 anti-HIV_048-005189_VR-Chain 2777 22-41 49-58 87-106 anti-HIV_048-005088_VR-Chain 2778 22-41 49-58 87-106 anti-HIV_048-004023_VR-Chain 2779 22-41 49-58 87-106 anti-HIV_048-001580_VR-Chain 2780 22-41 87-106 anti-HIV_038-221120_VR-Chain 2781 22-41 49-58 87-106 anti-HIV_038-197677_VR-Chain 2782 22-41 49-58 87-106 anti-HIV_038-196765_VR-Chain 2783 22-41 49-58 87-106 anti-HIV_038-186200_VR-Chain 2784 22-41 87-106 anti-HIV_038-126170_VR-Chain 2785 22-41 49-58 87-106 anti-HIV_038-108545_VR-Chain 2786 22-41 49-58 87-106 anti-HIV_038-107263_VR-Chain 2787 22-41 49-58 87-106 anti-HIV_038-104530_VR-Chain 2788 22-41 49-58 87-106 anti-HIV_038-099169_VR-Chain 2789 22-41 49-58 87-106 anti-HIV_038-075067_VR-Chain 2790 22-41 49-58 87-106 anti-HIV_038-072368_VR-Chain 2791 22-41 49-58 87-106 anti-HIV_038-068503_VR-Chain 2792 22-41 49-58 87-106 anti-HIV_038-068016_VR-Chain 2793 22-41 49-58 87-106 anti-HIV_038-063958_VR-Chain 2794 22-41 49-58 87-106 anti-HIV_038-033733_VR-Chain 2795 22-41 49-58 87-106 anti-HIV_038-030557_VR-Chain 2796 22-41 49-58 87-106 anti-HIV_038-024298_VR-Chain 2797 22-41 49-58 87-106 anti-HIV_038-011154_VR-Chain 2798 22-41 49-58 87-106 anti-HIV-1_LightChain 2799 22-41 49-58 87-106 anti-HIV-1_LightChain 2800 22-41 anti-HIV-1_LightChain 2801 22-41 46-55 anti-HIV-1_LightChain 2802 22-41 45-54 anti-HIV-1_LightChain 2803 22-41 45-54 anti-HIV-1_LightChain 2804 22-41 84-103 anti-HIV-1_LightChain 2805 22-41 45-54 83-102 anti-HIV-1_LightChain 2806 22-41 46-55 anti-HIV-1_LightChain 2807 22-41 45-54 83-102 anti-HIV-1_LightChain 2808 22-41 84-103 anti-HIV-1_LightChain 2809 22-41 48-57 anti-HIV-1_LightChain 2810 22-41 anti-HIV-1_LightChain 2811 22-41 anti-HIV-1_LightChain 2812 22-41 anti-HIV-1_LightChain 2813 22-41 anti-HIV-1_LightChain 2814 22-41 anti-HIV-1_LightChain 2815 22-41 anti-HIV-1_LightChain 2816 22-41 anti-HIV-1_LightChain 2817 22-41 anti-HIV-1_LightChain 2818 22-41 anti-HIV-1_LightChain 2819 22-41 anti-HIV-1_LightChain 2820 22-41 anti-HIV-1_HeavyChain 2821 22-41 74-83 anti-HIV-1_HeavyChain 2822 22-41 74-83 anti-HIV-1_HeavyChain 2823 22-41 anti-HIV-1_HeavyChain 2824 22-41 74-83 94-113 anti-HIV-1_HeavyChain 2825 22-41 74-83 anti-HIV-1_HeavyChain 2826 22-41 74-83 94-113 anti-HIV-1_HeavyChain 2827 22-41 anti-HIV-1_HeavyChain 2828 22-41 74-83 94-113 anti-HIV-1_HeavyChain 2829 22-41 74-83 anti-HIV-1_HeavyChain 2830 22-41 anti-HIV-1_HeavyChain 2831 22-41 86-105 anti-HIV-1_HeavyChain 2832 22-41 86-105 anti-HIV-1_HeavyChain 2833 22-41 86-105 anti-HIV-1_HeavyChain 2834 22-41 86-105 anti-HIV-1_HeavyChain 2835 22-41 anti-HIV-1_HeavyChain 2836 22-41 86-105 anti-HIV-1_HeavyChain 2837 22-41 100-119  anti-HIV-1_HeavyChain 2838 22-41 100-119  anti-HIV-1_HeavyChain 2839 22-41 100-119  anti-HIV-1_HeavyChain 2840 22-41 100-119  anti-HIV-1_HeavyChain 2841 22-41 100-119  anti-HIV-1_HeavyChain 2842 22-41 100-119  anti-HIV-1_HeavyChain 2843 22-41 100-119  anti-HIV-1_HeavyChain 2844 22-41 100-119  anti-HIV-1_HeavyChain 2845 22-41 100-119  anti-HIV-1_HeavyChain 2846 22-41 anti-HIV-1_HeavyChain 2847 22-41 anti-HIV-1_LightChain 2848 22-41 46-55 84-101 anti-HIV-1_HeavyChain 2849 22-41 anti-HIV-1_HeavyChain 2850 22-41 anti-HIV-1_HeavyChain 2851 22-41 35-44 anti-HIV-1_HeavyChain 2852 22-41 35-44 anti-HIV-1_HeavyChain 2853 22-41 35-44 anti-HIV-1_HeavyChain 2854 22-41 35-44 anti-HIV-1_HeavyChain 2855 22-41 35-44 anti-HIV-1_HeavyChain 2856 22-41 anti-HIV-1_HeavyChain 2857 22-41 anti-HIV-1_HeavyChain 2858 22-41 anti-HIV-1_HeavyChain 2859 22-41 anti-HIV-1_HeavyChain 2860 22-41 anti-HIV-1_HeavyChain 2861 22-41  95-104 anti-HIV-1_HeavyChain 2862 22-41 anti-HIV-1_HeavyChain 2863 22-41 anti-HIV-1_HeavyChain 2864 22-41 anti-HIV-1_HeavyChain 2865 22-41 anti-HIV-1_HeavyChain 2866 22-41 34-43 anti-HIV-1_HeavyChain 2867 22-41 anti-HIV-1_HeavyChain 2868 22-41 anti-HIV-1_HeavyChain 2869 22-41 anti-HIV-1_HeavyChain 2870 22-41 anti-HIV-1_HeavyChain 2871 22-41 95-114 anti-HIV-1_HeavyChain 2872 22-41 35-44 anti-HIV-1_HeavyChain 2873 22-41 anti-HIV-1_HeavyChain 2874 22-41 anti-HIV-1_HeavyChain 2875 22-41 anti-HIV-1_HeavyChain 2876 22-41 anti-HIV-1_HeavyChain 2877 22-41 96-115 anti-HIV-1_HeavyChain 2878 22-41 anti-HIV-1_HeavyChain 2879 22-41 anti-HIV-1_HeavyChain 2880 22-41 anti-HIV-1_HeavyChain 2881 22-41 anti-HIV-1_HeavyChain 2882 22-41 anti-HIV-1_HeavyChain 2883 22-41 anti-HIV-1_HeavyChain 2884 22-41 35-44 anti-HIV-1_HeavyChain 2885 22-41 anti-HIV-1_HeavyChain 2886 22-41 96-115 anti-HIV-1_HeavyChain 2887 22-41 anti-HIV-1_HeavyChain 2888 22-41 anti-HIV-1_HeavyChain 2889 22-41 34-43 anti-HIV-1_HeavyChain 2890 22-41 anti-HIV-1_HeavyChain 2891 22-41 anti-HIV-1_HeavyChain 2892 22-41 34-43 anti-HIV-1_HeavyChain 2893 22-41 34-43 anti-HIV-1_HeavyChain 2894 22-41 anti-HIV-1_HeavyChain 2895 22-41 anti-HIV-1_HeavyChain 2896 22-41 anti-HIV-1_HeavyChain 2897 22-41 anti-HIV-1_HeavyChain 2898 22-41 anti-HIV-1_HeavyChain 2899 22-41 anti-HIV-1_HeavyChain 2900 22-41 137-138 96-115 anti-HIV-1_HeavyChain 2901 22-41 96-115 anti-HIV-1_HeavyChain 2902 22-41 96-115 anti-HIV-1_HeavyChain 2903 22-41 34-43 anti-HIV-1_HeavyChain 2904 22-41 anti-HIV-1_HeavyChain 2905 22-41 anti-HIV-1_HeavyChain 2906 22-41 anti-HIV-1_HeavyChain 2907 22-41 35-44 anti-HIV-1_HeavyChain 2908 22-41 anti-HIV-1_HeavyChain 2909 22-41 anti-HIV-1_HeavyChain 2910 22-41 96-115 anti-HIV-1_HeavyChain 2911 22-41 96-115 anti-HIV-1_HeavyChain 2912 22-41 anti-HIV-1_HeavyChain 2913 22-41 anti-HIV-1_HeavyChain 2914 22-41 anti-HIV-1_HeavyChain 2915 22-41 anti-HIV-1_HeavyChain 2916 22-41 anti-HIV-1_HeavyChain 2917 22-41 anti-HIV-1_HeavyChain 2918 22-41 140-141 anti-HIV-1_HeavyChain 2919 22-41 anti-HIV-1_HeavyChain 2920 22-41 anti-HIV-1_HeavyChain 2921 22-41 96-115 anti-HIV-1_HeavyChain 2922 22-41 94-113 anti-HIV-1_HeavyChain 2923 22-41 anti-HIV-1_HeavyChain 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3736 22-41 anti-HIV-1_HeavyChain 3737 22-41 138-140 anti-HIV-1_HeavyChain 3738 22-41 anti-HIV-1_HeavyChain 3739 22-41 anti-HIV-1_HeavyChain 3740 22-41 137-139 anti-HIV-1_HeavyChain 3741 22-41 anti-HIV-1_HeavyChain 3742 22-41 anti-HIV-1_HeavyChain 3743 22-41 anti-HIV-1_HeavyChain 3744 22-41 35-44 anti-HIV-1_HeavyChain 3745 22-41 137-139 anti-HIV-1_HeavyChain 3746 22-41 anti-HIV-1_HeavyChain 3747 22-41 anti-HIV-1_HeavyChain 3748 22-41 139-141 anti-HIV-1_HeavyChain 3749 22-41 139-141 anti-HIV-1_HeavyChain 3750 22-41 139-141 anti-HIV-1_HeavyChain 3751 22-41 anti-HIV-1_HeavyChain 3752 22-41 anti-HIV-1_HeavyChain 3753 22-41 35-44 anti-HIV-1_HeavyChain 3754 22-41 anti-HIV-1_HeavyChain 3755 22-41 anti-HIV-1_HeavyChain 3756 22-41 anti-HIV-1_HeavyChain 3757 22-41 139-141 anti-HIV-1_HeavyChain 3758 22-41 anti-HIV-1_HeavyChain 3759 22-41 anti-HIV-1_HeavyChain 3760 22-41 35-44 anti-HIV-1_HeavyChain 3761 22-41 anti-HIV-1_HeavyChain 3762 22-41 anti-HIV-1_HeavyChain 3763 22-41 anti-HIV-1_HeavyChain 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anti-HIV-1_HeavyChain 3906 22-41 anti-HIV-1_HeavyChain 3907 22-41 35-44 anti-HIV-1_HeavyChain 3908 22-41 anti-HIV-1_HeavyChain 3909 22-41 anti-HIV-1_HeavyChain 3910 22-41 anti-HIV-1_HeavyChain 3911 22-41 anti-HIV-1_HeavyChain 3912 22-41 anti-HIV-1_HeavyChain 3913 22-41 anti-HIV-1_HeavyChain 3914 22-41 anti-HIV-1_HeavyChain 3915 22-41 anti-HIV-1_HeavyChain 3916 22-41 anti-HIV-1_HeavyChain 3917 22-41  93-102 94-113 anti-HIV-1_HeavyChain 3918 22-41 anti-HIV-1_HeavyChain 3919 22-41 anti-HIV-1_HeavyChain 3920 22-41 anti-HIV-1_HeavyChain 3921 22-41 anti-HIV-1_HeavyChain 3922 22-41 anti-HIV-1_HeavyChain 3923 22-41 anti-HIV-1_HeavyChain 3924 22-41 anti-HIV-1_HeavyChain 3925 22-41 anti-HIV-1_HeavyChain 3926 22-41 35-44 anti-HIV-1_HeavyChain 3927 22-41 35-44 anti-HIV-1_HeavyChain 3928 22-41 anti-HIV-1_HeavyChain 3929 22-41 anti-HIV-1_HeavyChain 3930 22-41 anti-HIV-1_HeavyChain 3931 22-41 35-44 anti-HIV-1_HeavyChain 3932 22-41 anti-HIV-1_HeavyChain 3933 22-41 35-44 anti-HIV-1_HeavyChain 3934 22-41 35-44 anti-HIV-1_HeavyChain 3935 22-41 anti-HIV-1_HeavyChain 3936 22-41 35-44 anti-HIV-1_HeavyChain 3937 22-41 anti-HIV-1_HeavyChain 3938 22-41 anti-HIV-1_HeavyChain 3939 22-41 anti-HIV-1_HeavyChain 3940 22-41 anti-HIV-1_HeavyChain 3941 22-41 anti-HIV-1_HeavyChain 3942 22-41  95-104 anti-HIV-1_HeavyChain 3943 22-41  95-104 anti-HIV-1_HeavyChain 3944 22-41 anti-HIV-1_HeavyChain 3945 22-41 anti-HIV-1_HeavyChain 3946 22-41 35-44 anti-HIV-1_HeavyChain 3947 22-41 anti-HIV-1_HeavyChain 3948 22-41 anti-HIV-1_HeavyChain 3949 22-41 anti-HIV-1_HeavyChain 3950 22-41 anti-HIV-1_HeavyChain 3951 22-41 anti-HIV-1_HeavyChain 3952 22-41 anti-HIV-1_HeavyChain 3953 22-41 anti-HIV-1_HeavyChain 3954 22-41 anti-HIV-1_HeavyChain 3955 22-41 anti-HIV-1_HeavyChain 3956 22-41 anti-HIV-1_HeavyChain 3957 22-41 anti-HIV-1_HeavyChain 3958 22-41 anti-HIV-1_HeavyChain 3959 22-41 anti-HIV-1_HeavyChain 3960 22-41 anti-HIV-1_HeavyChain 3961 22-41 anti-HIV-1_HeavyChain 3962 22-41 anti-HIV-1_HeavyChain 3963 22-41 96-115 anti-HIV-1_HeavyChain 3964 22-41 anti-HIV-1_HeavyChain 3965 22-41 anti-HIV-1_HeavyChain 3966 22-41 anti-HIV-1_HeavyChain 3967 22-41 anti-HIV-1_HeavyChain 3968 22-41 anti-HIV-1_HeavyChain 3969 22-41 96-115 anti-HIV-1_HeavyChain 3970 22-41 96-115 anti-HIV-1_HeavyChain 3971 22-41 96-115 anti-HIV-1_HeavyChain 3972 22-41 anti-HIV-1_HeavyChain 3973 22-41 95-114 anti-HIV-1_HeavyChain 3974 22-41 anti-HIV-1_HeavyChain 3975 22-41 96-115 anti-HIV-1_HeavyChain 3976 22-41 anti-HIV-1_HeavyChain 3977 22-41 96-115 anti-HIV-1_HeavyChain 3978 22-41 anti-HIV-1_HeavyChain 3979 22-41 96-115 anti-HIV-1_HeavyChain 3980 22-41 anti-HIV-1_HeavyChain 3981 22-41 anti-HIV-1_HeavyChain 3982 22-41 anti-HIV-1_HeavyChain 3983 22-41 96-115 anti-HIV-1_HeavyChain 3984 22-41 anti-HIV-1_HeavyChain 3985 22-41 anti-HIV-1_HeavyChain 3989 22-41 96-115 anti-HIV-1_HeavyChain 3987 22-41 anti-HIV-1_HeavyChain 3988 22-41 96-115 anti-HIV-1_HeavyChain 3989 22-41 95-114 anti-HIV-1_HeavyChain 3990 22-41 anti-HIV-1_HeavyChain 3991 22-41 anti-HIV-1_HeavyChain 3992 22-41 anti-HIV-1_HeavyChain 3993 22-41 anti-HIV-1_HeavyChain 3994 22-41 96-115 anti-HIV-1_HeavyChain 3995 22-41 anti-HIV-1_HeavyChain 3996 22-41 96-115 anti-HIV-1_HeavyChain 3997 22-41 96-115 anti-HIV-1_HeavyChain 3998 22-41 anti-HIV-1_HeavyChain 3999 22-41 95-114 anti-HIV-1_HeavyChain 4000 22-41 anti-HIV_5CIN_LightChain 4001 22-41 49-58 87-106 anti-HIV_5CIN_HeavyChain 4002 22-41 93-112 anti-HIV_5CIL_HeavyChain 4003 22-41 93-112 anti-HIV_5CIP_A-Chain 4004 22-41 93-112 anti-HIV_5CIP_HeavyChain 4005 22-41 93-112 anti-HIV_4JKP_LightChain 4006 22-41 46-55 84-103 anti-HIV_3TNN_E-Chain 4007 22-41 94-113 anti-HIV_3BQU_B-Chain 4008 22-41 53-62 anti-HIV_3BQU_A-Chain 4009 22-41 48-57 89-105 anti-HIV_1gG_VR-Chain 4010 22-41 69-78 107-126  anti-HIV_1gG_HeavyChain 4011 22-41 70-79 112-116  anti-HIV_4P9M_HeavyChain 4012 22-41 anti-HIV_4P9M_LightChain 4013 22-41 49-58 anti-HIV_4P9H_C-Chain 4014 22-41 anti-HIV_4YBL_A-Chain 4015 22-41 anti-HIV_4R4N_V-Chain 4016 22-41 294-303 anti-HIV_4JKP_G-Chain 4017 22-41 anti-HIV_3BQU_D-Chain 4018 22-41 113-132  anti-HIV_3BQU_C-Chain 4019 22-41 108-127  anti-HIV_1g_LightChain 4020 22-41 90-109 anti-HIV_1g_HeavyChain 4021 22-41 94-113 anti-HIV_4P9H_G-Chain 4022 22-41 anti-HIV_Chain 4023 22-41 anti-HIV_Chain 4024 22-41 anti-HIV_Chain 4025 22-41 anti-HIV_Chain 4026 22-41 53-62 anti-HIV_Chain 4027 22-41 65-84 anti-HIV_Chain 4028 22-41 67-86 anti-HIV_Chain 4029 22-41 65-84 anti-HIV_Chain 4030 22-41 anti-HIV_Chain 4031 22-41 anti-HIV_Chain 4032 22-41 anti-HIV_Chain 4033 22-41 82-100 anti-HIV_Chain 4034 22-41 82-100 anti-HIV_Chain 4035 22-41 82-100 anti-HIV_Chain 4036 22-41 anti-HIV_Chain 4037 22-41 anti-HIV_Chain 4038 22-41 anti-HIV_Chain 4039 22-41 84-102 anti-HIV_Chain 4040 22-41 84-102 anti-HIV_Chain 4041 22-41 82-101 anti-HIV_Chain 4042 22-41 anti-HIV_Chain 4043 22-41 44-53 anti-HIV_Chain 4044 22-41 44-53 anti-HIV_Chain 4045 22-41 44-53 anti-HIV_Chain 4046 22-41 44-53 anti-HIV_Chain 4047 22-41 44-53 anti-HIV_Chain 4048 22-41 44-53 anti-HIV_Chain 4049 22-41 83-102 anti-HIV_Chain 4050 22-41 83-102 anti-HIV_Chain 4051 22-41 44-53 anti-HIV_Chain 4052 22-41 71-80 72-91  anti-HIV_Chain 4053 22-41 anti-HIV_Chain 4054 22-41 40-49 81-100 anti-HIV_Chain 4055 22-41 40-49 81-100 anti-HIV_Chain 4056 22-41 40-49 81-100 anti-HIV_Chain 4057 22-41 81-100 anti-HIV_Chain 4058 22-41 83-102 anti-HIV_Chain 4059 22-41 anti-HIV_Chain 4060 22-41 32-41 74-93  anti-HIV_Chain 4061 22-41 42-51 83-102 anti-HIV_Chain 4062 22-41 42-51 83-102 anti-HIV_Chain 4063 22-41 anti-HIV_Chain 4064 22-41 anti-HIV_Chain 4065 22-41 anti-HIV_Chain 4066 22-41 anti-HIV_Chain 4067 22-41 46-55 84-103 anti-HIV_Chain 4068 22-41 anti-HIV_Chain 4069 22-41 anti-HIV_Chain 4070 22-41 43-52 84-103 anti-HIV_LightChain 4071 22-41 48-57 86-105 anti-HIV_LightChain 4072 22-41 48-57 86-105 anti-HIV_Chain 4073 22-41 83-102 anti-HIV_Chain 4074 22-41 38-47 76-95  anti-HIV_Chain 4075 22-41 47-56 85-104 anti-HIV_HeavyChain 4076 22-41 anti-HIV_Chain 4077 22-41 47-56 85-104 anti-HIV_Chain 4078 22-41 38-47 anti-HIV_LightChain 4079 22-41 54-63 92-111 anti-HIV_LightChain 4080 22-41 48-57 86-105 anti-HIV_Chain 4081 22-41 44-53 anti-HIV_Chain 4082 22-41 49-58 87-106 anti-HIV_Chain 4083 22-41 77-96  anti-HIV_Chain 4084 22-41 44-53 anti-HIV_Chain 4085 22-41 44-53 anti-HIV_Chain 4086 22-41 44-53 anti-HIV_Chain 4087 22-41 44-53 anti-HIV_Chain 4088 22-41 anti-HIV_Chain 4089 22-41 44-53 anti-HIV_Chain 4090 22-41 44-53 anti-HIV_Chain 4091 22-41 44-53 anti-HIV_Chain 4092 22-41 44-53 anti-HIV_Chain 4093 22-41 44-53 anti-HIV_Chain 4094 22-41 44-53 anti-HIV_Chain 4095 22-41 51-60 89-108 anti-HIV_Chain 4096 22-41 83-102 anti-HIV_Chain 4097 22-41 83-102 anti-HIV_Chain 4098 22-41 83-102 anti-HIV_Chain 4099 22-41 83-102 anti-HIV_Chain 4100 22-41 83-102 anti-HIV_Chain 4101 22-41 83-102 anti-HIV_Chain 4102 22-41 83-102 anti-HIV_Chain 4103 22-41 83-102 anti-HIV_Chain 4104 22-41 83-102 anti-HIV_Chain 4105 22-41 83-102 anti-HIV_Chain 4106 22-41 41-50 79-98  anti-HIV_Chain 4107 22-41 39-48 77-96  anti-HIV_Chain 4108 22-41 49-58 anti-HIV_Chain 4109 22-41 41-50 83-102 anti-HIV_Chain 4110 22-41 79-88 80-99  anti-HIV_Chain 4111 22-41 42-51 anti-HIV_Chain 4112 22-41 42-51 80-99  anti-HIV_LightChain 4113 22-41 49-58 anti-HIV_LightChain 4114 22-41 49-58 anti-HIV_LightChain 4115 22-41 49-58 anti-HIV_LightChain 4116 22-41 49-58 anti-HIV_LightChain 4117 22-41 49-58 anti-HIV_LightChain 4118 22-41 49-58 anti-HIV_LightChain 4119 22-41 49-58 anti-HIV_LightChain 4120 22-41 49-58 anti-HIV_LightChain 4121 22-41 49-58 anti-HIV_LightChain 4122 22-41 49-58 anti-HIV_LightChain 4123 22-41 49-58 anti-HIV_LightChain 4124 22-41 49-58 anti-HIV_LightChain 4125 22-41 49-58 anti-HIV_LightChain 4126 22-41 49-58 anti-HIV_LightChain 4127 22-41 49-58 anti-HIV_Chain 4128 22-41 102-117  anti-HIV_Chain 4129 22-41 41-50 79-98  anti-HIV_Chain 4130 22-41 anti-HIV_Chain 4131 22-41 anti-HIV_Chain 4132 22-41 anti-HIV_Chain 4133 22-41 82-101 anti-HIV_Chain 4134 22-41 anti-HIV_Chain 4135 22-41 43-52 anti-HIV_Chain 4136 22-41 anti-HIV_HeavyChain 4137 22-41 51-60 anti-HIV_Chain 4138 22-41 34-43 anti-HIV_Chain 4139 22-41 34-43 anti-HIV_Chain 4140 22-41 88-107 anti-HIV_Chain 4141 22-41 49-58 87-106 anti-HIV_Chain 4142 22-41 38-47 76-95  anti-HIV_Chain 4143 22-41 anti-HIV_Chain 4144 22-41 anti-HIV_Chain 4145 22-41 50-59 88-107 anti-HIV_Chain 4146 22-41 50-59 88-107 anti-HIV_Chain 4147 22-41 anti-HIV_Chain 4148 22-41 anti-HIV_Chain 4149 22-41 anti-HIV_Chain 4150 22-41 anti-HIV_Chain 4151 22-41 anti-HIV_Chain 4152 22-41 anti-HIV_Chain 4153 22-41 anti-HIV_Chain 4154 22-41 anti-HIV_Chain 4155 22-41 48-57 anti-HIV_Chain 4156 22-41 anti-HIV_Chain 4157 22-41  94-103 95-114 anti-HIV_HeavyChain 4158 22-41 94-113 anti-HIV_HeavyChain 4159 22-41 94-113 anti-HIV_Chain 4160 22-41 48-57 anti-HIV_Chain 4161 22-41 48-57 anti-HIV_Chain 4162 22-41 anti-HIV_Chain 4163 22-41 48-57 86-105 anti-HIV_Chain 4164 22-41 anti-HIV_Chain 4165 22-41 51-60 anti-HIV_Chain 4166 22-41 94-113 anti-HIV_Chain 4167 22-41  95-104 96-115 anti-HIV_Chain 4168 22-41 74-83 anti-HIV_Chain 4169 22-41 48-57 86-105 anti-HIV_Chain 4170 22-41 49-58 87-106 anti-HIV_Chain 4171 22-41 48-57 86-105 anti-HIV_Chain 4172 22-41 48-57 anti-HIV_Chain 4173 22-41 anti-HIV_Chain 4174 22-41 anti-HIV_Chain 4175 22-41 anti-HIV_Chain 4176 22-41 59-68 94-113 anti-HIV_Chain 4177 22-41 94-113 anti-HIV_Chain 4178 22-41 94-113 anti-HIV_Chain 4179 22-41 94-113 anti-HIV_Chain 4180 22-41  97-106 anti-HIV_Chain 4181 22-41  97-106 anti-HIV_Chain 4182 22-41  97-106 anti-HIV_Chain 4183 22-41 anti-HIV_Chain 4184 22-41 anti-HIV_Chain 4185 22-41 anti-HIV_Chain 4186 22-41 51-60 93-112 anti-HIV_Chain 4187 22-41 51-60 anti-HIV_Chain 4188 22-41 48-57 86-105 anti-HIV_Chain 4189 22-41 anti-HIV_Chain 4190 22-41 48-57 86-105 anti-HIV_Chain 4191 22-41 48-57 86-105 anti-HIV_Chain 4192 22-41 49-58 87-106 anti-HIV_Chain 4193 22-41 anti-HIV_Chain 4194 22-41 anti-HIV_Chain 4195 22-41 84-93 85-104 anti-HIV_Chain 4196 22-41 47-56 85-104 anti-HIV_Chain 4197 22-41 47-56 85-104 anti-HIV_Chain 4198 22-41 84-93 85-104 anti-HIV_Chain 4199 22-41 85-104 anti-HIV_Chain 4200 22-41 84-93 85-104 anti-HIV_Chain 4201 22-41  93-102 94-113 anti-HIV_Chain 4202 22-41 94-113 anti-HIV_Chain 4203 22-41 94-113 anti-HIV_Chain 4204 22-41 91-110 anti-HIV_Chain 4205 22-41 94-113 anti-HIV_HeavyChain 4206 22-41 51-60 94-113 anti-HIV_Chain 4207 22-41 anti-HIV_Chain 4208 22-41 anti-HIV_Chain 4209 22-41 58-67 94-113 anti-HIV_Chain 4210 22-41 48-57 86-105 anti-HIV_Chain 4211 22-41 49-58 87-106 anti-HIV_Chain 4212 22-41 49-58 87-106 anti-HIV_Chain 4213 22-41 85-104 anti-HIV_Chain 4214 22-41 anti-HIV_Chain 4215 22-41 anti-HIV_Chain 4216 22-41 48-57 anti-HIV_Chain 4217 22-41 34-43 anti-HIV_Chain 4218 22-41 34-43 anti-HIV_Chain 4219 22-41 34-43 anti-HIV_Chain 4220 22-41 34-43 anti-HIV_Chain 4221 22-41 34-43 anti-HIV_Chain 4222 22-41 34-43 anti-HIV_Chain 4223 22-41 34-43 anti-HIV_Chain 4224 22-41 34-43 anti-HIV_Chain 4225 22-41  93-102 anti-HIV_Chain 4226 22-41 34-43 anti-HIV_Chain 4227 22-41 34-43 anti-HIV_Chain 4228 22-41 34-43 anti-HIV_Chain 4229 22-41  93-102 anti-HIV_Chain 4230 22-41 34-43 anti-HIV_Chain 4231 22-41 34-43 anti-HIV_Chain 4232 22-41 34-43 anti-HIV_Chain 4233 22-41  93-102 anti-HIV_Chain 4234 22-41 94-113 anti-HIV_Chain 4235 22-41 58-67 94-113 anti-HIV_Chain 4236 22-41 94-113 anti-HIV_Chain 4237 22-41 anti-HIV_Chain 4238 22-41 94-113 anti-HIV_Chain 4239 22-41 anti-HIV_Chain 4240 22-41 anti-HIV_Chain 4241 22-41 94-113 anti-HIV_Chain 4242 22-41 94-113 anti-HIV_Chain 4243 22-41 96-115 anti-HIV_Chain 4244 22-41 48-57 86-105 anti-HIV_Chain 4245 22-41 50-59 88-107 anti-HIV_Chain 4246 22-41 anti-HIV_Chain 4247 22-41 49-58 anti-HIV_Chain 4248 22-41 48-57 86-105 anti-HIV_Chain 4249 22-41 35-44 anti-HIV_Chain 4250 22-41  93-102 anti-HIV_Chain 4251 22-41 94-113 anti-HIV_Chain 4252 22-41 95-114 anti-HIV_Chain 4253 22-41 anti-HIV_Chain 4254 22-41 anti-HIV_Chain 4255 22-41 anti-HIV_Chain 4256 22-41 51-60 93-112 anti-HIV_Chain 4257 22-41  92-101 93-112 anti-HIV_Chain 4258 22-41 93-112 anti-HIV_Chain 4259 22-41 93-112 anti-HIV_Chain 4260 22-41 94-113 anti-HIV_Chain 4261 22-41 anti-HIV_Chain 4262 22-41 94-113 anti-HIV_Chain 4263 22-41 53-62 95-114 anti-HIV_Chain 4264 22-41 anti-HIV_Chain 4265 22-41 94-113 anti-HIV_Chain 4266 22-41 94-113 anti-HIV_Chain 4267 22-41 anti-HIV_Chain 4268 22-41 51-60 93-112 anti-HIV_Chain 4269 22-41 94-113 anti-HIV_Chain 4270 22-41 94-113 anti-HIV_Chain 4271 22-41 94-113 anti-HIV_Chain 4272 22-41 49-58 87-106 anti-HIV_Chain 4273 22-41 49-58 87-106 anti-HIV_Chain 4274 22-41 49-58 87-106 anti-HIV_Chain 4275 22-41  93-102 94-113 anti-HIV_Chain 4276 22-41 anti-HIV_Chain 4277 22-41 anti-HIV_Chain 4278 22-41 88-107 anti-HIV_Chain 4279 22-41  93-102 94-113 anti-HIV_Chain 4280 22-41  93-102 94-113 anti-HIV_Chain 4281 22-41  93-102 94-113 anti-HIV_Chain 4282 22-41 94-113 anti-HIV_Chain 4283 22-41 93-112 anti-HIV_Chain 4284 22-41 94-113 anti-HIV_Chain 4285 22-41 94-113 anti-HIV_Chain 4286 22-41 anti-HIV_Chain 4287 22-41 anti-HIV_Chain 4288 22-41 94-113 anti-HIV_Chain 4289 22-41 94-113 anti-HIV_Chain 4290 22-41 58-67 94-113 anti-HIV_Chain 4291 22-41 anti-HIV_Chain 4292 22-41 93-112 anti-HIV_Chain 4293 22-41  93-102 94-113 anti-HIV_Chain 4294 22-41 49-58 87-106 anti-HIV_Chain 4295 22-41 anti-HIV_Chain 4296 22-41 anti-HIV_Chain 4297 22-41 anti-HIV_Chain 4298 22-41 anti-HIV_Chain 4299 22-41  93-102 94-113 anti-HIV_Chain 4300 22-41 53-62 95-114 anti-HIV_Chain 4301 22-41 94-113 anti-HIV_Chain 4302 22-41 93-112 anti-HIV_Chain 4303 22-41 anti-HIV_Chain 4304 22-41 74-83 94-113 anti-HIV_Chain 4305 22-41 anti-HIV_Chain 4306 22-41 74-83 anti-HIV_Chain 4307 22-41 74-83 anti-HIV_Chain 4308 22-41 94-113 anti-HIV_Chain 4309 22-41 94-113 anti-HIV_Chain 4310 22-41 94-113 anti-HIV_Chain 4311 22-41 74-83 anti-HIV_Chain 4312 22-41 74-83 anti-HIV_Chain 4313 22-41 74-83 anti-HIV_Chain 4314 22-41 74-83 94-113 anti-HIV_Chain 4315 22-41 83-92 94-113 anti-HIV_Chain 4316 22-41 53-62 95-114 anti-HIV_Chain 4317 22-41  93-102 94-113 anti-HIV_Chain 4318 22-41 28-37 anti-HIV_Chain 4319 22-41 93-112 anti-HIV_Chain 4320 22-41 anti-HIV_Chain 4321 22-41 49-58 anti-HIV_Chain 4322 22-41 anti-HIV_Chain 4323 22-41 anti-HIV_Chain 4324 22-41 anti-HIV_Chain 4325 22-41  97-106 anti-HIV_Chain 4326 22-41 anti-HIV_Chain 4327 22-41 anti-HIV_Chain 4328 22-41 anti-HIV_Chain 4329 22-41  97-106 anti-HIV_Chain 4330 22-41  97-106 anti-HIV_Chain 4331 22-41 anti-HIV_Chain 4332 22-41  97-106 anti-HIV_Chain 4333 22-41 anti-HIV_Chain 4334 22-41  97-106 anti-HIV_Chain 4335 22-41 anti-HIV_Chain 4336 22-41 anti-HIV_Chain 4337 22-41 anti-HIV_Chain 4338 22-41 anti-HIV_Chain 4339 22-41 anti-HIV_Chain 4340 22-41 anti-HIV_Chain 4341 22-41  97-106 anti-HIV_Chain 4342 22-41 anti-HIV_Chain 4343 22-41 anti-HIV_Chain 4344 22-41 anti-HIV_Chain 4345 22-41 anti-HIV_Chain 4346 22-41 anti-HIV_Chain 4347 22-41 anti-HIV_Chain 4348 22-41 anti-HIV_Chain 4349 22-41 anti-HIV_Chain 4350 22-41 anti-HIV_Chain 4351 22-41 anti-HIV_Chain 4352 22-41 96-115 anti-HIV_Chain 4353 22-41 94-113 anti-HIV_Chain 4354 22-41 94-113 anti-HIV_Chain 4355 22-41 96-115 anti-HIV_Chain 4356 22-41  92-101 anti-HIV_Chain 4357 22-41 anti-HIV_Chain 4358 22-41 93-112 anti-HIV_Chain 4359 22-41  93-102 anti-HIV_Chain 4360 22-41 94-113 anti-HIV_Chain 4361 22-41 anti-HIV_Chain 4362 22-41 anti-HIV_Chain 4363 22-41 93-112 anti-HIV_Chain 4364 22-41 94-113 anti-HIV_Chain 4365 22-41 94-113 anti-HIV_Chain 4366 22-41 59-68 94-113 anti-HIV_Chain 4367 22-41 59-68 94-113 anti-HIV_Chain 4368 22-41 94-113 anti-HIV_Chain 4369 22-41 94-113 anti-HIV_Chain 4370 22-41 94-113 anti-HIV_Chain 4371 22-41 94-113 anti-HIV_Chain 4372 22-41 94-113 anti-HIV_Chain 4373 22-41 94-113 anti-HIV_Chain 4374 22-41 94-113 anti-HIV_Chain 4375 22-41 93-112 anti-HIV_Chain 4376 22-41 50-59 88-107 anti-HIV_Chain 4377 22-41 88-107 anti-HIV_Chain 4378 22-41 93-112 anti-HIV_Chain 4379 22-41 anti-HIV_Chain 4380 22-41 anti-HIV_Chain 4381 22-41 anti-HIV_Chain 4382 22-41 anti-HIV_Chain 4383 22-41 86-95 anti-HIV_Chain 4384 22-41 94-113 anti-HIV_Chain 4385 22-41 anti-HIV_Chain 4386 22-41 anti-HIV_Chain 4387 22-41 49-58 anti-HIV_Chain 4388 22-41 anti-HIV_Chain 4389 22-41 anti-HIV_Chain 4390 22-41 anti-HIV_Chain 4391 22-41 anti-HIV_Chain 4392 22-41 anti-HIV_Chain 4393 22-41 49-58 anti-HIV_Chain 4394 22-41 anti-HIV_Chain 4395 22-41 anti-HIV_Chain 4396 22-41 93-112 anti-HIV_Chain 4397 22-41 anti-HIV_Chain 4398 22-41 93-112 anti-HIV_Chain 4399 22-41 94-113 anti-HIV_Chain 4400 22-41 93-112 anti-HIV_Chain 4401 22-41 93-112 anti-HIV_Chain 4402 22-41 93-112 anti-HIV_Chain 4403 22-41 93-112 anti-HIV_Chain 4404 22-41 93-112 anti-HIV_Chain 4405 22-41 93-112 anti-HIV_Chain 4406 22-41 93-112 anti-HIV_Chain 4407 22-41 59-68 94-113 anti-HIV_Chain 4408 22-41 93-112 anti-HIV_Chain 4409 22-41 93-112 anti-HIV_Chain 4410 22-41 anti-HIV_Chain 4411 22-41  93-102 anti-HIV_Chain 4412 22-41  93-102 anti-HIV_Chain 4413 22-41 anti-HIV_Chain 4414 22-41 74-83 anti-HIV_Chain 4415 22-41 93-112 anti-HIV_Chain 4416 22-41  93-102 anti-HIV_Chain 4417 22-41  93-102 anti-HIV_Chain 4418 22-41 74-83 anti-HIV_Chain 4419 22-41 93-112 anti-HIV_Chain 4420 22-41 93-112 anti-HIV_Chain 4421 22-41 93-112 anti-HIV_Chain 4422 22-41 93-112 anti-HIV_Chain 4423 22-41 93-112 anti-HIV_Chain 4424 22-41 94-113 anti-HIV_Chain 4425 22-41  93-102 94-113 anti-HIV_Chain 4426 22-41 94-113 anti-HIV_Chain 4427 22-41 anti-HIV_Chain 4428 22-41 anti-HIV_Chain 4429 22-41 anti-HIV_Chain 4430 22-41 96-115 anti-HIV_Chain 4431 22-41 53-62 95-114 anti-HIV_Chain 4432 22-41 94-113 anti-HIV_Chain 4433 22-41 50-59 88-107 anti-HIV_Chain 4434 22-41 50-59 88-107 anti-HIV_Chain 4435 22-41 anti-HIV_Chain 4436 22-41 anti-HIV_Chain 4437 22-41 anti-HIV_Chain 4438 22-41 anti-HIV_Chain 4439 22-41 anti-HIV_Chain 4440 22-41 anti-HIV_Chain 4441 22-41 anti-HIV_Chain 4442 22-41 anti-HIV_Chain 4443 22-41 anti-HIV_Chain 4444 22-41 anti-HIV_Chain 4445 22-41 59-68 94-113 anti-HIV_Chain 4446 22-41 94-113 anti-HIV_Chain 4447 22-41  93-102 94-113 anti-HIV_Chain 4448 22-41 97-116 anti-HIV_Chain 4449 22-41  92-101 anti-HIV_Chain 4450 22-41 anti-HIV_Chain 4451 22-41 anti-HIV_Chain 4452 22-41 anti-HIV_Chain 4453 22-41 anti-HIV_Chain 4454 22-41 anti-HIV_Chain 4455 22-41 anti-HIV_Chain 4456 22-41 anti-HIV_Chain 4457 22-41 anti-HIV_Chain 4458 22-41 anti-HIV_Chain 4459 22-41 anti-HIV_Chain 4460 22-41 anti-HIV_Chain 4461 22-41 anti-HIV_Chain 4462 22-41 anti-HIV_Chain 4463 22-41 anti-HIV_Chain 4464 22-41 103-122  anti-HIV_Chain 4465 22-41 93-112 anti-HIV_Chain 4466 22-41 58-67 94-113 anti-HIV_Chain 4467 22-41 108-117 anti-HIV_Chain 4468 22-41 50-59 88-107 anti-HIV_Chain 4469 22-41 93-112 anti-HIV_Chain 4470 22-41 96-115 anti-HIV_Chain 4471 22-41 55-64 anti-HIV_LightChain 4472 22-41 72-81 110-129  anti-HIV_Chain 4473 22-41 104-113 93-112 anti-HIV_Chain 4474 22-41 104-113 anti-HIV_Chain 4475 22-41 104-113 93-112 anti-HIV_Chain 4476 22-41 104-113 93-112 anti-HIV_Chain 4477 22-41 104-113 93-112 anti-HIV_Chain 4478 22-41 104-113 93-112 anti-HIV_Chain 4479 22-41 104-113 anti-HIV_Chain 4480 22-41  92-101 anti-HIV_Chain 4481 22-41 104-113 93-112 anti-HIV_Chain 4482 22-41 104-113 93-112 anti-HIV_Chain 4483 22-41 anti-HIV_Chain 4484 22-41 anti-HIV_Chain 4485 22-41 anti-HIV_Chain 4486 22-41 anti-HIV_Chain 4487 22-41 59-68 94-113 anti-HIV_Chain 4488 22-41 94-113 anti-HIV_Chain 4489 22-41 94-113 anti-HIV_Chain 4490 22-41  92-101 93-112 anti-HIV_Chain 4491 22-41 94-113 anti-HIV_Chain 4492 22-41 59-68 94-113 anti-HIV_Chain 4493 22-41 94-113 anti-HIV_Chain 4494 22-41 94-113 anti-HIV_Chain 4495 22-41 59-68 94-113 anti-HIV_Chain 4496 22-41 94-113 anti-HIV_Chain 4497 22-41 59-68 94-113 anti-HIV_Chain 4498 22-41 100-119  anti-HIV_Chain 4499 22-41 100-119  anti-HIV_Chain 4500 22-41 anti-HIV_Chain 4501 22-41  93-102 94-113 anti-HIV_Chain 4502 22-41 100-119  anti-HIV_Chain 4503 22-41 94-113 anti-HIV_Chain 4504 22-41 94-113 anti-HIV_Chain 4505 22-41  93-102 94-113 anti-HIV_Chain 4506 22-41 97-116 anti-HIV_Chain 4507 22-41 97-116 anti-HIV_Chain 4508 22-41 94-113 anti-HIV_Chain 4509 22-41 94-113 anti-HIV_Chain 4510 22-41 94-113 anti-HIV_Chain 4511 22-41 94-113 anti-HIV_Chain 4512 22-41 94-113 anti-HIV_Chain 4513 22-41 97-116 anti-HIV_Chain 4514 22-41 59-68 94-113 anti-HIV_Chain 4515 22-41 94-113 anti-HIV_Chain 4516 22-41 97-116 anti-HIV_Chain 4517 22-41 93-112 anti-HIV_Chain 4518 22-41 anti-HIV_Chain 4519 22-41 96-115 anti-HIV_Chain 4520 22-41  93-102 94-113 anti-HIV_Chain 4521 22-41 56-65 98-117 anti-HIV_Chain 4522 22-41 95-114 anti-HIV_Chain 4523 22-41 95-114 anti-HIV_Chain 4524 22-41 94-113 anti-HIV_Chain 4525 22-41 anti-HIV_Chain 4526 22-41 94-113 anti-HIV_Chain 4527 22-41  93-102 anti-HIV_Chain 4528 22-41 anti-HIV_Chain 4529 22-41  93-102 anti-HIV_Chain 4530 22-41  93-102 anti-HIV_Chain 4531 22-41 anti-HIV_Chain 4532 22-41  93-102 anti-HIV_Chain 4533 22-41 anti-HIV_Chain 4534 22-41 94-113 anti-HIV_Chain 4535 22-41 anti-HIV_Chain 4536 22-41 anti-HIV_Chain 4537 22-41 anti-HIV_Chain 4538 22-41 anti-HIV_Chain 4539 22-41 anti-HIV_Chain 4540 22-41 anti-HIV_Chain 4541 22-41 anti-HIV_Chain 4542 22-41 anti-HIV_LightChain 4543 22-41 72-81 110-129  anti-HIV_Chain 4544 22-41 anti-HIV_Chain 4545 22-41 anti-HIV_Chain 4546 22-41 57-66 99-118 anti-HIV_Chain 4547 22-41 96-115 anti-HIV_Chain 4548 22-41 anti-HIV_Chain 4549 22-41  94-103 95-114 anti-HIV_Chain 4550 22-41 97-116 anti-HIV_Chain 4551 22-41 94-113 anti-HIV_Chain 4552 22-41 94-113 anti-HIV_Chain 4553 22-41 anti-HIV_Chain 4554 22-41 anti-HIV_Chain 4555 22-41 anti-HIV_Chain 4556 22-41 anti-HIV_Chain 4557 22-41 94-113 anti-HIV_Chain 4558 22-41 94-113 anti-HIV_Chain 4559 22-41 58-67 anti-HIV_Chain 4560 22-41 94-113 anti-HIV_Chain 4561 22-41 94-113 anti-HIV_Chain 4562 22-41 60-69 95-114 anti-HIV_HeavyChain 4563 22-41 anti-HIV_HeavyChain 4564 22-41 anti-HIV_HeavyChain 4565 22-41 anti-HIV_Chain 4566 22-41 anti-HIV_Chain 4567 22-41 96-115 anti-HIV_Chain 4568 22-41 101-120  anti-HIV_Chain 4569 22-41 96-115 anti-HIV_Chain 4570 22-41 61-70 96-115 anti-HIV_Chain 4571 22-41  93-102 94-113 anti-HIV_Chain 4572 22-41  93-102 94-113 anti-HIV_Chain 4573 22-41 94-113 anti-HIV_Chain 4574 22-41 55-64 anti-HIV_HeavyChain 4575 22-41 anti-HIV_HeavyChain 4576 22-41 anti-HIV_HeavyChain 4577 22-41 anti-HIV_HeavyChain 4578 22-41 anti-HIV_HeavyChain 4579 22-41 anti-HIV_HeavyChain 4580 22-41 anti-HIV_HeavyChain 4581 22-41 anti-HIV_HeavyChain 4582 22-41 anti-HIV_HeavyChain 4583 22-41 anti-HIV_HeavyChain 4584 22-41 anti-HIV_HeavyChain 4585 22-41 anti-HIV_HeavyChain 4586 22-41 anti-HIV_HeavyChain 4587 22-41 anti-HIV_Chain 4588 22-41 anti-HIV_Chain 4589 22-41 anti-HIV_Chain 4590 22-41 94-113 anti-HIV_Chain 4591 22-41 94-113 anti-HIV_Chain 4592 22-41 94-113 anti-HIV_Chain 4593 22-41 94-113 anti-HIV_Chain 4594 22-41 94-113 anti-HIV_Chain 4595 22-41 94-113 anti-HIV_Chain 4596 22-41 94-113 anti-HIV_Chain 4597 22-41 94-113 anti-HIV_Chain 4598 22-41 94-113 anti-HIV_Chain 4599 22-41 100-119  anti-HIV_Chain 4600 22-41 94-113 anti-HIV_Chain 4601 22-41  93-102 94-113 anti-HIV_Chain 4602 22-41 94-113 anti-HIV_Chain 4603 22-41 93-112 anti-HIV_Chain 4604 22-41 81-100 anti-HIV_Chain 4605 22-41 94-113 anti-HIV_Chain 4606 22-41 94-113 anti-HIV_HeavyChain 4607 22-41 70-79 113-132  anti-HIV_HeavyChain 4608 22-41 70-79 113-132  anti-HIV_Chain 4609 22-41 60-69 96-115 anti-HIV_Chain 4610 22-41 62-71 100-119  anti-HIV_Chain 4611 22-41 anti-HIV_Chain 4612 22-41 anti-HIV_Chain 4613 22-41 108-127  anti-HIV_Chain 4614 22-41 52-61 anti-HIV_HeavyChain 4615 22-41 70-79 113-132  anti-HIV_HeavyChain 4616 22-41 70-79 113-132  anti-HIV_Chain 4617 22-41 93-112 anti-HIV_Chain 4618 22-41 93-112 anti-HIV_Chain 4619 22-41 93-112 anti-HIV_Chain 4620 22-41  93-102 anti-HIV_Chain 4621 22-41 59-68 94-113 anti-HIV_Chain 4622 22-41 59-68 94-113 anti-HIV_Chain 4623 22-41 anti-HIV_Chain 4624 22-41 59-68 94-113 anti-HIV_LightChain 4625 22-41 48-57 86-105 anti-HIV_Chain 4626 22-41 49-58 anti-HIV_Chain 4627 22-41 54-63 92-111 anti-HIV_SingleChain 4628 22-41 95-114 anti-HIV_LightChain 4629 22-41 anti-HIV_Chain 4630 22-41 anti-HIV_Chain 4631 22-41 113-132  anti-influenza_Fab 4632 22-41 47-56 85-104 anti-influenza_Fab 4633 22-41 93-112 anti-influenza_Fab 4634 22-41 226-235 anti-influenza_Fab 4635 22-41 94-113 anti-influenza_Fab 4636 22-41 48-57 86-105 anti-influenza_Fab 4637 22-41 anti-influenza_Fab 4638 22-41 anti-influenza_Apo 4639 22-41 85-104 anti-influenza_Apo 4640 22-41 94-113 anti-influenza-A_kappa_LightChain_V-Region 4641 22-41 52-61 90-109 anti-influenza-A_kappa_LightChain_V-Region 4642 22-41 52-61 90-109 anti-influenza-A_kappa_LightChain_V-Region 4643 22-41 52-61 90-109 anti-influenza-A_kappa_LightChain_V-Region 4644 22-41 52-61 90-109 anti-influenza-A_kappa_LightChain_V-Region 4645 22-41 54-63 92-111 anti-influenza-A_kappa_LightChain_V-Region 4646 22-41 52-61 90-109 anti-influenza-A_HeavyChain_V-Region 4647 22-41 94-113 anti-influenza-A_HeavyChain_V-Region 4648 22-41 94-113 anti-influenza-A_HeavyChain_V-Region 4649 22-41 94-113 anti-influenza-A_HeavyChain_V-Region 4650 22-41 94-113 anti-influenza-A_HeavyChain_V-Region 4651 22-41 94-113 anti-influenza-A_HeavyChain_V-Region 4652 22-41 94-113 anti-influenza-A_HeavyChain_V-Region 4653 22-41 94-113 anti-influenza-A_LightChain_V-Region 4654 22-41 49-58 87-106 anti-influenza-A_HeavyChain_V-Region 4655 22-41 94-113 anti-influenza_Chain 4656 22-41 anti-influenza_Chain 4657 22-41 anti-influenza_Chain 4658 22-41 51-60 anti-influenza_Chain 4659 22-41 anti-influenza_Chain 4660 22-41 84-100 anti-influenza_Chain 4661 22-41 45-54 83-100 anti-influenza_Chain 4662 22-41 47-56 85-102 anti-influenza_Chain 4663 22-41 47-56 85-102 anti-influenza_Chain 4664 22-41 48-57 86-103 anti-influenza_Chain 4665 22-41 48-57 86-103 anti-influenza_Chain 4666 22-41 48-57 86-103 anti-influenza_Chain 4667 22-41 48-57 86-103 anti-influenza_Chain 4668 22-41 48-57 86-103 anti-influenza_Chain 4669 22-41 48-57 86-103 anti-influenza_Chain 4670 22-41 48-57 86-103 anti-influenza_Chain 4671 22-41 48-57 86-103 anti-influenza_Chain 4672 22-41 48-57 86-103 anti-influenza_Chain 4673 22-41 86-105 anti-influenza_Chain 4674 22-41 86-105 anti-influenza_Chain 4675 22-41 anti-influenza_Chain 4676 22-41 48-57 86-105 anti-influenza_Chain 4677 22-41 48-57 anti-influenza_Chain 4678 22-41 86-105 anti-influenza_Chain 4679 22-41 86-105 anti-influenza_Chain 4680 22-41 48-57 anti-influenza_Chain 4681 22-41 86-105 anti-influenza_Chain 4682 22-41 48-57 anti-influenza_Chain 4683 22-41 29-38 86-105 anti-influenza_Chain 4684 22-41 29-38 86-105 anti-influenza_Chain 4685 22-41 86-105 anti-influenza_Chain 4686 22-41 86-105 anti-influenza_Chain 4687 22-41 86-105 anti-influenza_Chain 4688 22-41 48-57 86-105 anti-influenza_Chain 4689 22-41 29-38 anti-influenza_Chain 4690 22-41 48-57 86-105 anti-influenza_Chain 4691 22-41 86-105 anti-influenza_Chain 4692 22-41 86-105 anti-influenza_Chain 4693 22-41 86-105 anti-influenza_Chain 4694 22-41 48-57 86-105 anti-influenza_Chain 4695 22-41 31-40 86-105 anti-influenza_Chain 4695 22-41 48-57 anti-influenza_Chain 4697 22-41 86-105 anti-influenza_Chain 4698 22-41 48-57 86-105 anti-influenza_Chain 4699 22-41 29-38 86-105 anti-influenza_Chain 4700 22-41 anti-influenza_Chain 4701 22-41 86-105 anti-influenza_Chain 4702 22-41 86-105 anti-influenza_Chain 4703 22-41 48-57 86-105 anti-influenza_Chain 4704 22-41 86-105 anti-influenza_Chain 4705 22-41 86-105 anti-influenza_Chain 4706 22-41 48-57 86-105 anti-influenza_Chain 4707 22-41 48-57 anti-influenza_Chain 4708 22-41 86-105 anti-influenza_Chain 4709 22-41 29-38 86-105 anti-influenza_Chain 4710 22-41 47-56 85-104 anti-influenza_Chain 4711 22-41 48-57 86-105 anti-influenza_Chain 4712 22-41  97-106 87-106 anti-influenza_Chain 4713 22-41  97-106 87-106 anti-influenza_Chain 4714 22-41 85-94 86-105 anti-influenza_Chain 4715 22-41 29-38 86-105 anti-influenza_Chain 4716 22-41 48-57 anti-influenza_Chain 4717 22-41 48-57 anti-influenza_Chain 4718 22-41 48-57 anti-influenza_Chain 4719 22-41 48-57 86-105 anti-influenza_Chain 4720 22-41 48-57 86-105 anti-influenza_Chain 4721 22-41 48-57 86-105 anti-influenza_Chain 4722 22-41 48-57 86-105 anti-influenza_Chain 4723 22-41 48-57 86-105 anti-influenza_Chain 4724 22-41 49-58 87-106 anti-influenza_Chain 4725 22-41 49-58 87-106 anti-influenza_Chain 4726 22-41 49-58 87-106 anti-influenza_Chain 4727 22-41 48-57 86-105 anti-influenza_Chain 4728 22-41 49-58 87-106 anti-influenza_Chain 4729 22-41 49-58 anti-influenza_Chain 4730 22-41 87-106 anti-influenza_Chain 4731 22-41 48-57 86-105 anti-influenza_Chain 4732 22-41 47-56 85-104 anti-influenza_Chain 4733 22-41 85-104 anti-influenza_Chain 4734 22-41 49-58 87-106 anti-influenza_Chain 4735 22-41 48-57 86-105 anti-influenza_Chain 4736 22-41 90-108 anti-influenza_Chain 4737 22-41 48-57 86-105 anti-influenza_Chain 4738 22-41 87-106 anti-influenza_Chain 4739 22-41 48-57 85-105 anti-influenza_Chain 4740 22-41 47-56 anti-influenza_Chain 4741 22-41 47-56 anti-influenza_Chain 4742 22-41  98-107 88-107 anti-influenza_Chain 4743 22-41 89-108 anti-influenza_Chain 4744 22-41 anti-influenza_Chain 4745 22-41 86-105 anti-influenza_Chain 4746 22-41 49-58 87-106 anti-influenza_Chain 4747 22-41 48-57 86-105 anti-influenza_Chain 4748 22-41 49-58 87-106 anti-influenza_Chain 4749 22-41 49-58 anti-influenza_Chain 4750 22-41 49-58 anti-influenza_Chain 4751 22-41 48-57 86-105 anti-influenza_Chain 4752 22-41 88-107 anti-influenza_Chain 4753 22-41 48-57 86-105 anti-influenza_Chain 4754 22-41 48-57 86-105 anti-influenza_Chain 4755 22-41 48-57 86-105 anti-influenza_Chain 4756 22-41 48-57 86-105 anti-influenza_Chain 4757 22-41 48-57 86-105 anti-influenza_Chain 4758 22-41 49-58 87-106 anti-influenza_Chain 4759 22-41 85-104 anti-influenza_Chain 4760 22-41 49-58 87-106 anti-influenza_Chain 4761 22-41 85-104 anti-influenza_Chain 4762 22-41 49-58 87-106 anti-influenza_Chain 4763 22-41 85-104 anti-influenza_Chain 4764 22-41 85-104 anti-influenza_Chain 4765 22-41 87-106 anti-influenza_Chain 4766 22-41 85-104 anti-influenza_Chain 4767 22-41 85-104 anti-influenza_Chain 4768 22-41 49-58 87-106 anti-influenza_Chain 4769 22-41 86-105 anti-influenza_Chain 4770 22-41 86-105 anti-influenza_Chain 4771 22-41 86-105 anti-influenza_Chain 4772 22-41 86-105 anti-influenza_Chain 4773 22-41 86-105 anti-influenza_Chain 4774 22-41 86-105 anti-influenza_Chain 4775 22-41 86-105 anti-influenza_Chain 4776 22-41 86-105 anti-influenza_Chain 4777 22-41 86-105 anti-influenza_Chain 4778 22-41 48-57 86-105 anti-influenza_Chain 4779 22-41 48-57 86-105 anti-influenza_Chain 4780 22-41 48-57 86-105 anti-influenza_Chain 4781 22-41 48-57 86-105 anti-influenza_Chain 4782 22-41 48-57 86-105 anti-influenza_Chain 4783 22-41 48-57 86-105 anti-influenza_Chain 4784 22-41 48-57 86-105 anti-influenza_Chain 4785 22-41 48-57 86-105 anti-influenza_Chain 4786 22-41 48-57 86-105 anti-influenza_Chain 4787 22-41 48-57 86-105 anti-influenza_Chain 4788 22-41 48-57 86-105 anti-influenza_Chain 4789 22-41 48-57 anti-influenza_Chain 4790 22-41 29-38 86-105 anti-influenza_Chain 4791 22-41 48-57 86-105 anti-influenza_Chain 4792 22-41 48-57 86-105 anti-influenza_Chain 4793 22-41 86-105 anti-influenza_Chain 4794 22-41 87-106 anti-influenza_Chain 4795 22-41 49-58 87-106 anti-influenza_Chain 4796 22-41 48-57 86-105 anti-influenza_Chain 4797 22-41 49-58 87-106 anti-influenza_Chain 4798 22-41 50-59 anti-influenza_Chain 4799 22-41 50-59 88-107 anti-influenza_Chain 4800 22-41 50-59 88-107 anti-influenza_Chain 4801 22-41 49-58 87-106 anti-influenza_Chain 4802 22-41 anti-influenza_Chain 4803 22-41 50-59 89-108 anti-influenza_Chain 4804 22-41 48-57 86-105 anti-influenza_Chain 4805 22-41 49-58 87-106 anti-influenza_Chain 4806 22-41 88-107 anti-influenza_Chain 4807 22-41 49-58 87-106 anti-influenza_Chain 4808 22-41 48-57 86-105 anti-influenza_Chain 4809 22-41 85-104 anti-influenza_Chain 4810 22-41 87-106 anti-influenza_Chain 4811 22-41 48-57 86-105 anti-influenza_Chain 4812 22-41 48-57 86-105 anti-influenza_Chain 4813 22-41 48-57 anti-influenza_Chain 4814 22-41 85-104 anti-influenza_Chain 4815 22-41 86-105 anti-influenza_Chain 4816 22-41 50-59 88-107 anti-influenza_Chain 4817 22-41 50-59 88-107 anti-influenza_Chain 4818 22-41 50-59 88-107 anti-influenza_Chain 4819 22-41 88-107 anti-influenza_Chain 4820 22-41 50-59 88-107 anti-influenza_Chain 4821 22-41 50-59 88-107 anti-influenza_Chain 4822 22-41 50-59 88-107 anti-influenza_Chain 4823 22-41 88-107 anti-influenza_Chain 4824 22-41 88-107 anti-influenza_Chain 4825 22-41 88-107 anti-influenza_Chain 4826 22-41 52-61 90-109 anti-influenza_Chain 4827 22-41 50-59 88-107 anti-influenza_Chain 4828 22-41 49-58 87-106 anti-influenza_Chain 4829 22-41 49-58 87-106 anti-influenza_Chain 4830 22-41 50-59 88-107 anti-influenza_Chain 4831 22-41 49-58 89-108 anti-influenza_Chain 4832 22-41 49-58 87-106 anti-influenza_Chain 4833 22-41 48-57 86-105 anti-influenza_Chain 4834 22-41 49-58 87-106 anti-influenza_Chain 4835 22-41 50-59 88-107 anti-influenza_Chain 4836 22-41 87-106 anti-influenza_Chain 4837 22-41 48-57 86-105 anti-influenza_Chain 4838 22-41 50-59 88-107 anti-influenza_Chain 4839 22-41 49-58 87-106 anti-influenza_Chain 4840 22-41 50-59 88-107 anti-influenza_Chain 4841 22-41 49-58 87-106 anti-influenza_Chain 4842 22-41 50-59 88-107 anti-influenza_Chain 4843 22-41 anti-influenza_Chain 4844 22-41 87-106 anti-influenza_Chain 4845 22-41 anti-influenza_Chain 4846 22-41 anti-influenza_Chain 4847 22-41 anti-influenza_Chain 4848 22-41 31-40 90-109 anti-influenza_Chain 4849 22-41 31-40 90-109 anti-influenza_Chain 4850 22-41 48-57 86-105 anti-influenza_Chain 4851 22-41 92-111 anti-influenza_Chain 4852 22-41 53-62 91-110 anti-influenza_Chain 4853 22-41 91-110 anti-influenza_Chain 4854 22-41 91-110 anti-influenza_Chain 4855 22-41 53-62 91-110 anti-influenza_Chain 4856 22-41 50-59 88-107 anti-influenza_Chain 4857 22-41 88-107 anti-influenza_Chain 4858 22-41 49-58 87-106 anti-influenza_Chain 4859 22-41 49-58 87-106 anti-influenza_Chain 4860 22-41 53-62 91-110 anti-influenza_Chain 4861 22-41 87-106 anti-influenza_Chain 4862 22-41 50-59 88-107 anti-influenza_Chain 4863 22-41 anti-influenza_Chain 4864 22-41 anti-influenza_Chain 4865 22-41 anti-influenza_Chain 4866 22-41 anti-influenza_Chain 4867 22-41 53-62 91-110 anti-influenza_Chain 4868 22-41 54-63 92-111 anti-influenza_Chain 4869 22-41 54-63 92-111 anti-influenza_Chain 4870 22-41 54-63 92-111 anti-influenza_Chain 4871 22-41 54-63 anti-influenza_Chain 4872 22-41 53-62 91-110 anti-influenza_Chain 4873 22-41 88-107 anti-influenza_Chain 4874 22-41 54-63 92-111 anti-influenza_Chain 4875 22-41 54-63 92-111 anti-influenza_Chain 4876 22-41 48-57 86-105 anti-influenza_Chain 4877 22-41 48-57 anti-influenza_Chain 4878 22-41 53-62 91-110 anti-influenza_Chain 4879 22-41 53-62 91-110 anti-influenza_Chain 4880 22-41 94-113 anti-influenza_Chain 4881 22-41 94-113 anti-influenza_Chain 4882 22-41 94-113 anti-influenza_Chain 4883 22-41 94-113 anti-influenza_Chain 4884 22-41 36-45 91-110 anti-influenza_Chain 4885 22-41 50-59 88-107 anti-influenza_Chain 4886 22-41 54-63 92-111 anti-influenza_Chain 4887 22-41 53-62 91-110 anti-influenza_Chain 4888 22-41 89-98 90-109 anti-influenza_Chain 4889 22-41 94-113 anti-influenza_Chain 4890 22-41 51-60 anti-influenza_Chain 4891 22-41 31-40 94-113 anti-influenza_Chain 4892 22-41 52-61 94-113 anti-influenza_Chain 4893 22-41 anti-influenza_Chain 4894 22-41 94-113 anti-influenza_Chain 4895 22-41 94-113 anti-influenza_Chain 4896 22-41 94-113 anti-influenza_Chain 4897 22-41 91-110 anti-influenza_Chain 4898 22-41 anti-influenza_Chain 4899 22-41 94-113 anti-influenza_Chain 4900 22-41 93-112 anti-influenza_Chain 4901 22-41 93-112 anti-influenza_Chain 4902 22-41 93-112 anti-influenza_Chain 4903 22-41 95-114 anti-influenza_Chain 4904 22-41 94-113 anti-influenza_Chain 4905 22-41 94-113 anti-influenza_Chain 4906 22-41 51-60 anti-influenza_Chain 4907 22-41 51-60 93-112 anti-influenza_Chain 4908 22-41 51-60 93-112 anti-influenza_Chain 4909 22-41 51-60 93-112 anti-influenza_Chain 4910 22-41 93-112 anti-influenza_Chain 4911 22-41 94-113 anti-influenza_Chain 4912 22-41 94-113 anti-influenza_Chain 4913 22-41 93-112 anti-influenza_Chain 4914 22-41 anti-influenza_Chain 4915 22-41 53-62 95-114 anti-influenza_Chain 4916 22-41  93-102 anti-influenza_Chain 4917 22-41 94-113 anti-influenza_Chain 4918 22-41 93-112 anti-influenza_Chain 4919 22-41 51-60 93-112 anti-influenza_Chain 4920 22-41 93-112 anti-influenza_Chain 4921 22-41  92-101 93-112 anti-influenza_Chain 4922 22-41 51-60 93-112 anti-influenza_Chain 4923 22-41 51-60 anti-influenza_Chain 4924 22-41 anti-influenza_Chain 4925 22-41 94-113 anti-influenza_Chain 4926 22-41 94-113 anti-influenza_Chain 4927 22-41 94-113 anti-influenza_Chain 4928 22-41 94-113 anti-influenza_Chain 4929 22-41 94-113 anti-influenza_Chain 4930 22-41 94-113 anti-influenza_Chain 4931 22-41 94-113 anti-influenza_Chain 4932 22-41 94-113 anti-influenza_Chain 4933 22-41 94-113 anti-influenza_Chain 4934 22-41 59-68 94-113 anti-influenza_Chain 4935 22-41 94-113 anti-influenza_Chain 4936 22-41 94-113 anti-influenza_Chain 4937 22-41 95-114 anti-influenza_Chain 4938 22-41 94-113 anti-influenza_Chain 4939 22-41 94-113 anti-influenza_Chain 4940 22-41 anti-influenza_Chain 4941 22-41 34-43 94-113 anti-influenza_Chain 4942 22-41 51-60 anti-influenza_Chain 4943 22-41 92-111 anti-influenza_Chain 4944 22-41 100-109 94-113 anti-influenza_Chain 4945 22-41 93-112 anti-influenza_Chain 4946 22-41 93-112 anti-influenza_Chain 4947 22-41 anti-influenza_Chain 4948 22-41 94-113 anti-influenza_Chain 4949 22-41 94-113 anti-influenza_Chain 4950 22-41 94-113 anti-influenza_Chain 4951 22-41 103-112 94-113 anti-influenza_Chain 4952 22-41 anti-influenza_Chain 4953 22-41 94-113 anti-influenza_Chain 4954 22-41 94-113 anti-influenza_Chain 4955 22-41  93-102 94-113 anti-influenza_Chain 4956 22-41 94-113 anti-influenza_Chain 4957 22-41 94-113 anti-influenza_Chain 4958 22-41 58-67 94-113 anti-influenza_Chain 4959 22-41 58-67 94-113 anti-influenza_Chain 4960 22-41 51-60 94-113 anti-influenza_Chain 4961 22-41 94-113 anti-influenza_Chain 4962 22-41 94-113 anti-influenza_Chain 4963 22-41 anti-influenza_Chain 4964 22-41 94-113 anti-influenza_Chain 4965 22-41 anti-influenza_Chain 4966 22-41 51-60 93-112 anti-influenza_Chain 4967 22-41 94-113 anti-influenza_Chain 4968 22-41 anti-influenza_Chain 4969 22-41  93-102 94-113 anti-influenza_Chain 4970 22-41 94-113 anti-influenza_Chain 4971 22-41 anti-influenza_Chain 4972 22-41 58-67 94-113 anti-influenza_Chain 4973 22-41 94-113 anti-influenza_Chain 4974 22-41 94-113 anti-influenza_Chain 4975 22-41 94-113 anti-influenza_Chain 4976 22-41 94-113 anti-influenza_Chain 4977 22-41 94-113 anti-influenza_Chain 4978 22-41 93-112 anti-influenza_Chain 4979 22-41 93-112 anti-influenza_Chain 4980 22-41 94-113 anti-influenza_Chain 4981 22-41 anti-influenza_Chain 4982 22-41 94-113 anti-influenza_Chain 4983 22-41 53-62 95-114 anti-influenza_Chain 4984 22-41 94-113 anti-influenza_Chain 4985 22-41 53-62 95-114 anti-influenza_Chain 4986 22-41 94-113 anti-influenza_Chain 4987 22-41 anti-influenza_Chain 4988 22-41 51-60 94-113 anti-influenza_Chain 4989 22-41 95-114 anti-influenza_Chain 4990 22-41  93-102 94-113 anti-influenza_Chain 4991 22-41  93-102 94-113 anti-influenza_Chain 4992 22-41 59-68 94-113 anti-influenza_Chain 4993 22-41 59-68 94-113 anti-influenza_Chain 4994 22-41 59-68 94-113 anti-influenza_Chain 4995 22-41 59-68 94-113 anti-influenza_Chain 4996 22-41 59-68 94-113 anti-influenza_Chain 4997 22-41 59-68 94-113 anti-influenza_Chain 4998 22-41 59-68 94-113 anti-influenza_Chain 4999 22-41 59-68 94-113 anti-influenza_Chain 5000 22-41 59-68 94-113 anti-influenza_Chain 5001 22-41 94-113 anti-influenza_Chain 5002 22-41 93-112 anti-influenza_Chain 5003 22-41 53-62 95-114 anti-influenza_Chain 5004 22-41 53-62 95-114 anti-influenza_Chain 5005 22-41 94-113 anti-influenza_Chain 5006 22-41  93-102 anti-influenza_Chain 5007 22-41 51-60 94-113 anti-influenza_Chain 5008 22-41 51-60 anti-influenza_Chain 5009 22-41 94-113 anti-influenza_Chain 5010 22-41 53-62 95-114 anti-influenza_Chain 5011 22-41 51-60 anti-influenza_Chain 5012 22-41 94-113 anti-influenza_Chain 5013 22-41  93-102 94-113 anti-influenza_Chain 5014 22-41 51-60 94-113 anti-influenza_Chain 5015 22-41 94-113 anti-influenza_Chain 5016 22-41 53-62 95-114 anti-influenza_Chain 5017 22-41 94-113 anti-influenza_Chain 5018 22-41 51-60 94-113 anti-influenza_Chain 5019 22-41 51-60 94-113 anti-influenza_Chain 5020 22-41 94-113 anti-influenza_Chain 5021 22-41 94-113 anti-influenza_Chain 5022 22-41 94-113 anti-influenza_Chain 5023 22-41 94-113 anti-influenza_Chain 5024 22-41 anti-influenza_Chain 5025 22-41 94-113 anti-influenza_Chain 5026 22-41 anti-influenza_Chain 5027 22-41 94-113 anti-influenza_Chain 5028 22-41 98-117 anti-influenza_Chain 5029 22-41 51-60 93-112 anti-influenza_Chain 5030 22-41 94-113 anti-influenza_Chain 5031 22-41 anti-influenza_Chain 5032 22-41 92-111 anti-influenza_Chain 5033 22-41 94-113 anti-influenza_Chain 5034 22-41 94-113 anti-influenza_Chain 5035 22-41 94-113 anti-influenza_Chain 5036 22-41 94-113 anti-influenza_Chain 5037 22-41 53-62 95-114 anti-influenza_Chain 5038 22-41 54-63 94-113 anti-influenza_Chain 5039 22-41 31-40 94-113 anti-influenza_Chain 5040 22-41  96-105 97-116 anti-influenza_Chain 5041 22-41 93-112 anti-influenza_Chain 5042 22-41 51-60 94-113 anti-influenza_Chain 5043 22-41 anti-influenza_Chain 5044 22-41 anti-influenza_Chain 5045 22-41  96-105 97-116 anti-influenza_Chain 5046 22-41  96-105 97-116 anti-influenza_Chain 5047 22-41  96-105 97-116 anti-influenza_Chain 5048 22-41 anti-influenza_Chain 5049 22-41 97-116 anti-influenza_Chain 5050 22-41 97-116 anti-influenza_Chain 5051 22-41 97-116 anti-influenza_Chain 5052 22-41 97-116 anti-influenza_Chain 5053 22-41 94-113 anti-influenza_Chain 5054 22-41 93-112 anti-influenza_Chain 5055 22-41  92-101 93-112 anti-influenza_Chain 5056 22-41 93-112 anti-influenza_Chain 5057 22-41 95-114 anti-influenza_Chain 5058 22-41 94-113 anti-influenza_Chain 5059 22-41 94-113 anti-influenza_Chain 5060 22-41 94-113 anti-influenza_Chain 5061 22-41 98-117 anti-influenza_Chain 5062 22-41 anti-influenza_Chain 5063 22-41 anti-influenza_Chain 5064 22-41 anti-influenza_Chain 5065 22-41 114-123 94-113 anti-influenza_Chain 5066 22-41 94-113 anti-influenza_Chain 5067 22-41 94-113 anti-influenza_Chain 5068 22-41 94-113 anti-influenza_Chain 5069 22-41 51-60 93-112 anti-influenza_Chain 5070 22-41 94-113 anti-influenza_Chain 5071 22-41 anti-influenza_Chain 5072 22-41 96-115 anti-influenza_Chain 5073 22-41 51-60 94-113 anti-influenza_Chain 5074 22-41 94-113 anti-influenza_Chain 5075 22-41 anti-influenza_Chain 5076 22-41 94-113 anti-influenza_Chain 5077 22-41 53-62 95-114 anti-influenza_Chain 5078 22-41 94-113 anti-influenza_Chain 5079 22-41 95-114 anti-influenza_Chain 5080 22-41 anti-influenza_Chain 5081 22-41 94-113 anti-influenza_Chain 5082 22-41 94-113 anti-influenza_Chain 5083 22-41 94-113 anti-influenza_Chain 5084 22-41 95-114 anti-influenza_Chain 5085 22-41 95-114 anti-influenza_Chain 5086 22-41 anti-influenza_Chain 5087 22-41  93-102 94-113 anti-influenza_Chain 5088 22-41 96-115 anti-influenza_Chain 5089 22-41 96-115 anti-influenza_Chain 5090 22-41 96-115 anti-influenza_Chain 5091 22-41 96-115 anti-influenza_Chain 5092 22-41 96-115 anti-influenza_Chain 5093 22-41 96-115 anti-influenza_Chain 5094 22-41 96-115 anti-influenza_Chain 5095 22-41 96-115 anti-influenza_Chain 5096 22-41 96-115 anti-influenza_Chain 5097 22-41 96-115 anti-influenza_Chain 5098 22-41 96-115 anti-influenza_Chain 5099 22-41 96-115 anti-influenza_Chain 5100 22-41 99-118 anti-influenza_Chain 5101 22-41 anti-influenza_Chain 5102 22-41 anti-influenza_Chain 5103 22-41 122-131 anti-influenza_Chain 5104 22-41 183-192 anti-influenza_Chain 5105 22-41 48-57 86-105 anti-influenza_Chain 5106 22-41 86-105 anti-influenza_Chain 5107 22-41 48-57 86-105 anti-influenza_Chain 5108 22-41 49-58 87-106 anti-influenza_Chain 5109 22-41 47-56 85-104 anti-influenza_Chain 5110 22-41 48-57 anti-influenza_Chain 5111 22-41 anti-influenza_Chain 5112 22-41 48-57 86-105 anti-influenza_Chain 5113 22-41  97-106 87-106 anti-influenza_Chain 5114 22-41  97-106 87-106 anti-influenza_Chain 5115 22-41 47-56 85-104 anti-influenza_Chain 5116 22-41 50-59 88-107 anti-influenza_Chain 5117 22-41 86-105 anti-influenza_Chain 5118 22-41 86-105 anti-influenza_Chain 5119 22-41 86-105 anti-influenza_Chain 5120 22-41 86-105 anti-influenza_Chain 5121 22-41 86-105 anti-influenza_Chain 5122 22-41 86-105 anti-influenza_Chain 5123 22-41 86-105 anti-influenza_Chain 5124 22-41 86-105 anti-influenza_Chain 5125 22-41 86-105 anti-influenza_Chain 5126 22-41 48-57 86-105 anti-influenza_Chain 5127 22-41 48-57 86-105 anti-influenza_Chain 5128 22-41 48-57 86-105 anti-influenza_Chain 5129 22-41 48-57 86-105 anti-influenza_Chain 5130 22-41 48-57 86-105 anti-influenza_Chain 5131 22-41 48-57 86-105 anti-influenza_Chain 5132 22-41 48-57 86-105 anti-influenza_Chain 5133 22-41 48-57 86-105 anti-influenza_Chain 5134 22-41 53-62 91-110 anti-influenza_Chain 5135 22-41 87-106 anti-influenza_Chain 5136 22-41  98-107 88-107 anti-influenza_Chain 5137 22-41 49-58 87-106 anti-influenza_Chain 5138 22-41 49-58 87-106 anti-influenza_Chain 5139 22-41 49-58 87-106 anti-influenza_Chain 5140 22-41 85-104 anti-influenza_Chain 5141 22-41 85-104 anti-influenza_Chain 5142 22-41 anti-influenza_Chain 5143 22-41 49-58 87-106 anti-influenza_Chain 5144 22-41 53-62 91-110 anti-influenza_Chain 5145 22-41 49-58 87-106 anti-influenza_Chain 5146 22-41 50-59 88-107 anti-influenza_Chain 5147 22-41 87-106 anti-influenza_Chain 5148 22-41 49-58 87-106 anti-influenza_Chain 5149 22-41 50-59 88-107 anti-influenza_Chain 5150 22-41 49-58 87-106 anti-influenza_Chain 5151 22-41 49-58 87-106 anti-influenza_Chain 5152 22-41 145-154 anti-influenza_Chain 5153 22-41 anti-influenza_Chain 5154 22-41 anti-influenza_Chain 5155 22-41 106-125  anti-influenza_Chain 5156 22-41 68-77 anti-influenza_Chain 5157 22-41 105-114 anti-influenza_Chain 5158 22-41 69-78 107-126  anti-influenza_Chain 5159 22-41 69-78 107-126  anti-influenza_Chain 5160 22-41 68-77 anti-influenza_Chain 5161 22-41 anti-influenza_Chain 5162 22-41 183-192 94-113 anti-influenza_Chain 5163 22-41 184-193 94-113 anti-influenza_Chain 5164 22-41 anti-influenza_Chain 5165 22-41 184-193 222-241  anti-influenza_Chain 5166 22-41 185-194 94-113 anti-influenza_Chain 5167 22-41 94-113 anti-influenza_Chain 5168 22-41 185-194 94-113 anti-influenza_Chain 5169 22-41 94-113 anti-influenza_Chain 5170 22-41 94-113 anti-influenza_Chain 5171 22-41 94-113 anti-influenza_Chain 5172 22-41 58-67 94-113 anti-influenza_Chain 5173 22-41 94-113 anti-influenza_Chain 5174 22-41 186-195 94-113 anti-influenza_Chain 5175 22-41 31-40 94-113 anti-influenza_Chain 5176 22-41 222-241  anti-influenza_Chain 5177 22-41 186-195 94-113 anti-influenza_Chain 5178 22-41 94-113 anti-influenza_Chain 5179 22-41 186-195 94-113 anti-influenza_Chain 5180 22-41 186-195 94-113 anti-influenza_Chain 5181 22-41 187-196 94-113 anti-influenza_Chain 5182 22-41 94-113 anti-influenza_Chain 5183 22-41 186-195 94-113 anti-influenza_Chain 5184 22-41 103-112 94-113 anti-influenza_Chain 5185 22-41 anti-influenza_Chain 5186 22-41 186-195 94-113 anti-influenza_Chain 5187 22-41 188-197 94-113 anti-influenza_Chain 5188 22-41 94-113 anti-influenza_Chain 5189 22-41 196-205 92-111 anti-influenza_Chain 5190 22-41 196-205 92-111 anti-influenza_Chain 5191 22-41 anti-influenza_Chain 5192 22-41 anti-influenza_Chain 5193 22-41 anti-influenza_Chain 5194 22-41 anti-influenza_Chain 5195 22-41 48-57 223-242  anti-influenza_Chain 5196 22-41 48-57 223-242  anti-influenza_Chain 5197 22-41 anti-influenza_Chain 5198 22-41 anti-influenza_Chain 5199 22-41 118-127 anti-influenza_Chain 5200 22-41 118-127 anti-influenza_Chain 5201 22-41 anti-influenza_Chain 5202 22-41 anti-influenza_Chain 5203 22-41 anti-influenza_Chain 5204 22-41 anti-influenza_Chain 5205 22-41 anti-influenza_Chain 5206 22-41 anti-influenza_Chain 5207 22-41 298-307 anti-influenza_Chain 5208 22-41 298-307 anti-influenza_Chain 5209 22-41 anti-influenza_Chain 5210 22-41 anti-influenza_Chain 5211 22-41 anti-influenza_Chain 5212 22-41 anti-influenza_Chain 5213 22-41 anti-influenza_Chain 5214 22-41 anti-influenza_Chain 5215 22-41 189-198 anti-influenza_Chain 5216 22-41 189-198 anti-influenza_Chain 5217 22-41 anti-influenza_Chain 5218 22-41 anti-influenza_Chain 5219 22-41 anti-influenza_Chain 5220 22-41 anti-influenza_Chain 5221 22-41 240-249 anti-influenza_Chain 5222 22-41 51-60 94-113 anti-influenza_Chain 5223 22-41 51-60 94-113 anti-influenza_Chain 5224 22-41 240-249 anti-influenza_Chain 5225 22-41 267-276 anti-influenza_Chain 5226 22-41 267-276 anti-influenza_Chain 5227 22-41 anti-influenza_Chain 5228 22-41 anti-influenza_Chain 5229 22-41 anti-influenza_Chain 5230 22-41 anti-influenza_Chain 5231 22-41 anti-influenza_Chain 5232 22-41 anti-influenza_Chain 5233 22-41 anti-influenza_Chain 5234 22-41 anti-influenza_Chain 5235 22-41 anti-influenza_Chain 5236 22-41 anti-influenza_Chain 5237 22-41 204-213 anti-influenza_Chain 5238 22-41 204-213 anti-influenza_Chain 5239 22-41 96-115 anti-influenza_Chain 5240 22-41 96-115 anti-influenza_Chain 5241 22-41 94-113 anti-influenza_Chain 5242 22-41 94-113 anti-influenza_Chain 5243 22-41 anti-influenza_Chain 5244 22-41 anti-influenza_Chain 5245 22-41 95-114 anti-influenza_Chain 5246 22-41 95-114 anti-influenza_Chain 5247 22-41 94-113 anti-influenza_Chain 5248 22-41 anti-influenza_Chain 5249 22-41 94-113 anti-influenza_Chain 5250 22-41 94-113 anti-influenza_Chain 5251 22-41 94-113 anti-influenza_Chain 5252 22-41 94-113 anti-influenza_Chain 5253 22-41 94-113 anti-influenza_Chain 5254 22-41 94-113 anti-influenza_Chain 5255 22-41 94-113 anti-influenza_Chain 5256 22-41 94-113 anti-influenza_Chain 5257 22-41 94-113 anti-influenza_Chain 5258 22-41 anti-influenza_Chain 5259 22-41 94-113 anti-influenza_Chain 5260 22-41 94-113 anti-influenza_Chain 5261 22-41 94-113 anti-influenza_Chain 5262 22-41 94-113 anti-influenza_Chain 5263 22-41 94-113 anti-influenza_Chain 5264 22-41 103-112 94-113 anti-influenza_Chain 5265 22-41 94-113 anti-influenza_Chain 5266 22-41 94-113 anti-influenza_Chain 5267 22-41 103-112 94-113 anti-influenza_Chain 5268 22-41 58-67 94-113 anti-influenza_Chain 5269 22-41 94-113 anti-influenza_Chain 5270 22-41  93-102 94-113 anti-influenza_Chain 5271 22-41 94-113 anti-influenza_Chain 5272 22-41 58-67 94-113 anti-influenza_Chain 5273 22-41  93-102 94-113 anti-influenza_Chain 5274 22-41 94-113 anti-influenza_Chain 5275 22-41  93-102 94-113 anti-influenza_Chain 5276 22-41  93-102 94-113 anti-influenza_Chain 5277 22-41 59-68 94-113 anti-influenza_Chain 5278 22-41 59-68 94-113 anti-influenza_Chain 5279 22-41 59-68 94-113 anti-influenza_Chain 5280 22-41 59-68 94-113 anti-influenza_Chain 5281 22-41 59-68 94-113 anti-influenza_Chain 5282 22-41 59-68 94-113 anti-influenza_Chain 5283 22-41 59-68 94-113 anti-influenza_Chain 5284 22-41 59-68 94-113 anti-influenza_Chain 5285 22-41 59-68 94-113 anti-influenza_Chain 5286 22-41 94-113 anti-influenza_Chain 5287 22-41  93-102 94-113 anti-influenza_Chain 5288 22-41  93-102 94-113 anti-influenza_Chain 5289 22-41 59-68 94-113 anti-influenza_Chain 5290 22-41 59-68 94-113 anti-influenza_Chain 5291 22-41 59-68 94-113 anti-influenza_Chain 5292 22-41 59-68 94-113 anti-influenza_Chain 5293 22-41 59-68 94-113 anti-influenza_Chain 5294 22-41 59-68 94-113 anti-influenza_Chain 5295 22-41 59-68 94-113 anti-influenza_Chain 5296 22-41 59-68 94-113 anti-influenza_Chain 5297 22-41 59-68 94-113 anti-influenza_Chain 5298 22-41 51-60 94-113 anti-influenza_Chain 5299 22-41 51-60 94-113 anti-influenza_Chain 5300 22-41 94-113 anti-influenza_Chain 5301 22-41 94-113 anti-influenza_Chain 5302 22-41 94-113 anti-influenza_Chain 5303 22-41 94-113 anti-influenza_Chain 5304 22-41 anti-influenza_Chain 5305 22-41 51-60 94-113 anti-influenza_Chain 5306 22-41 51-60 94-113 anti-influenza_Chain 5307 22-41 94-113 anti-influenza_Chain 5308 22-41 94-113 anti-influenza_Chain 5309 22-41 94-113 anti-influenza_Chain 5310 22-41 94-113 anti-influenza_Chain 5311 22-41 anti-influenza_Chain 5312 22-41 94-113 anti-influenza_Chain 5313 22-41 anti-influenza_Chain 5314 22-41 anti-influenza_Chain 5315 22-41 115-134  anti-influenza_Chain 5316 22-41 115-134  anti-influenza_Chain 5317 22-41 113-132  anti-influenza_Chain 5318 22-41 anti-influenza_Chain 5319 22-41 anti-influenza_Chain 5320 22-41 113-132  anti-influenza_Chain 5321 22-41 445-454 anti-influenza_Chain 5322 22-41 445-454 anti-influenza_Chain 5323 22-41 anti-influenza_Chain 5324 22-41 anti-influenza_Chain 5325 22-41 anti-influenza_Chain 5326 22-41 anti-influenza_Chain 5327 22-41 anti-influenza_Chain 5328 22-41 113-132  anti-influenza_Chain 5329 22-41 113-132  anti-influenza_Chain 5330 22-41 113-132  anti-influenza_Chain 5331 22-41 anti-influenza_Chain 5332 22-41 anti-influenza_Chain 5333 22-41 anti-influenza_Chain 5334 22-41 anti-influenza_Chain 5335 22-41 113-132  anti-influenza_Chain 5336 22-41 113-132  anti-influenza_Chain 5337 22-41 113-132  anti-influenza_Chain 5338 22-41 anti-influenza_Chain 5339 22-41 anti-influenza_Chain 5340 22-41 263-272 anti-influenza_Chain 5341 22-41 263-272 anti-influenza_Chain 5342 22-41 anti-influenza_Chain 5343 22-41 anti-influenza_Chain 5344 22-41 264-273 anti-influenza_Chain 5345 22-41 264-273 anti-influenza_Chain 5346 22-41  96-105 anti-influenza_Chain 5347 22-41  96-105 anti-influenza_Chain 5348 22-41  96-105 anti-influenza_Chain 5349 22-41  96-105 anti-influenza_Chain 5350 22-41  96-105 anti-influenza_Chain 5351 22-41  96-105 anti-influenza_Chain 5352 22-41 275-284 anti-influenza_Chain 5353 22-41 275-284 anti-influenza_Chain 5354 22-41 34-43 anti-influenza_Chain 5355 22-41 34-43 anti-influenza_Chain 5356 22-41 anti-influenza_Chain 5357 22-41 anti-influenza_Chain 5358 22-41 509-518 anti-influenza_Chain 5359 22-41 509-518 anti-influenza_Chain 5360 22-41 509-518 anti-influenza_Chain 5361 22-41 509-518 anti-influenza_Chain 5362 22-41 509-518 anti-influenza_Chain 5363 22-41 509-518 anti-influenza_Chain 5364 22-41 509-518 anti-influenza_Chain 5365 22-41 509-518 anti-influenza_Chain 5366 22-41 513-522 anti-influenza_Chain 5367 22-41 513-522 anti-influenza_Chain 5368 22-41 513-522 anti-influenza_Chain 5369 22-41 513-522 anti-influenza_Chain 5370 22-41 232-241 anti-influenza_Chain 5371 22-41 232-241 anti-influenza_Chain 5372 22-41 209-218 anti-influenza_Chain 5373 22-41 anti-influenza_Chain 5374 22-41 anti-influenza_Chain 5375 22-41 209-218 anti-influenza_Chain 5376 22-41 517-526 anti-influenza_Chain 5377 22-41 517-526 anti-influenza_Chain 5378 22-41 anti-influenza_Chain 5379 22-41 anti-influenza_Chain 5380 22-41 anti-influenza_Chain 5381 22-41 519-528 anti-influenza_Chain 5382 22-41 519-528 anti-influenza_Chain 5383 22-41 anti-influenza_Chain 5384 22-41 anti-influenza_Chain 5385 22-41 anti-influenza_Chain 5386 22-41 519-528 anti-influenza_Chain 5387 22-41 519-528 anti-influenza_Chain 5388 22-41 164-173 anti-influenza_Chain 5389 22-41 anti-influenza_Chain 5390 22-41 anti-influenza_Chain 5391 22-41 535-544 anti-influenza_Chain 5392 22-41 164-173 anti-influenza_Chain 5393 22-41 anti-influenza_Chain 5394 22-41 anti-influenza_Chain 5395 22-41 535-544 anti-influenza_Chain 5396 22-41 anti-influenza_Chain 5397 22-41 14-23 anti-influenza_Chain 5398 22-41 anti-influenza_Chain 5399 22-41 14-23 anti-influenza_Chain 5400 22-41 525-534 anti-influenza_Chain 5401 22-41 525-534 anti-influenza_Chain 5402 22-41 531-540 anti-influenza_Chain 5403 22-41 531-540 anti-influenza_Chain 5404 22-41 529-538 anti-influenza_Chain 5405 22-41 529-538 anti-influenza_Chain 5406 22-41 529-538 anti-influenza_Chain 5407 22-41 151-160 anti-influenza_Chain 5408 22-41 532-541 anti-influenza_Chain 5409 22-41 532-541 anti-influenza_Chain 5410 22-41 532-541 anti-influenza_Chain 5411 22-41 532-541 anti-influenza_Chain 5412 22-41 532-541 anti-influenza_Chain 5413 22-41 532-541 anti-influenza_Chain 5414 22-41 61-70 anti-influenza_Chain 5415 22-41 61-70 anti-influenza_Chain 5416 22-41 151-160 anti-influenza_Chain 5417 22-41 529-538 anti-influenza_Chain 5418 22-41 529-538 anti-influenza_Chain 5419 22-41 529-538 anti-influenza_Chain 5420 22-41 532-541 anti-influenza_Chain 5421 22-41 532-541 anti-influenza_Chain 5422 22-41 532-541 anti-influenza_Chain 5423 22-41 532-541 anti-influenza_Chain 5424 22-41 532-541 anti-influenza_Chain 5425 22-41 532-541 anti-influenza_Chain 5426 22-41 248-257 anti-influenza_Chain 5427 22-41 248-257 anti-influenza_Chain 5428 22-41 248-257 anti-influenza_Chain 5429 22-41 248-257 anti-influenza_Chain 5430 22-41 248-257 anti-influenza_Chain 5431 22-41 248-257 anti-influenza_Chain 5432 22-41 248-257 anti-influenza_Chain 5433 22-41 533-542 anti-influenza_Chain 5434 22-41 527-536 anti-influenza_Chain 5435 22-41 527-536 anti-influenza_Chain 5436 22-41 533-542 anti-influenza_Chain 5437 22-41 248-257 anti-influenza_Chain 5438 22-41 527-536 anti-influenza_Chain 5439 22-41 527-536 anti-influenza_Chain 5440 22-41 248-257 anti-influenza_Chain 5441 22-41 248-257 anti-influenza_Chain 5442 22-41 248-257 anti-influenza_Chain 5443 22-41 248-257 anti-influenza_Chain 5444 22-41 248-257 anti-influenza_Chain 5445 22-41 248-257 anti-influenza_Chain 5446 22-41 529-538 anti-influenza_Chain 5447 22-41 529-538 anti-influenza_Chain 5448 22-41 534-543 anti-influenza_Chain 5449 22-41 534-543 anti-influenza_Chain 5450 22-41 anti-influenza_Chain 5451 22-41 534-543 anti-influenza_Chain 5452 22-41 anti-influenza_Chain 5453 22-41 529-538 anti-influenza_Chain 5454 22-41 529-538 anti-influenza_Chain 5455 22-41 534-543 anti-influenza_Chain 5456 22-41 534-543 anti-influenza_Chain 5457 22-41 534-543 anti-influenza_Chain 5458 22-41 529-538 anti-influenza_Chain 5459 22-41 535-544 anti-influenza_Chain 5460 22-41 529-538 anti-influenza_Chain 5461 22-41 529-538 anti-influenza_Chain 5462 22-41 535-544 anti-influenza_Chain 5463 22-41 529-538 anti-influenza_Chain 5464 22-41 anti-influenza_Chain 5465 22-41 anti-influenza_Chain 5466 22-41 anti-influenza_Chain 5467 22-41 232-241 anti-influenza_Chain 5468 22-41 anti-influenza_Chain 5469 22-41 232-241 anti-influenza_Chain 5470 22-41 anti-influenza_Chain 5471 22-41 488-497 anti-influenza_Chain 5472 22-41 190-199 anti-influenza_Chain 5473 22-41 anti-influenza_Chain 5474 22-41 488-497 anti-influenza_Chain 5475 22-41 190-199 anti-influenza_Chain 5476 22-41 510-519 anti-influenza_Chain 5477 22-41 61-70 anti-influenza_Chain 5478 22-41 510-519 anti-influenza_Chain 5479 22-41 61-70 anti-influenza_Chain 5480 22-41 anti-influenza_Chain 5481 22-41 anti-influenza_Chain 5482 22-41 anti-influenza_Chain 5483 22-41 anti-influenza_Chain 5484 22-41 anti-influenza_Chain 5485 22-41 anti-influenza_Chain 5486 22-41 513-522 anti-influenza_Chain 5487 22-41 anti-influenza_Chain 5488 22-41 190-199 anti-influenza_Chain 5489 22-41 513-522 anti-influenza_Chain 5490 22-41 anti-influenza_Chain 5491 22-41 190-199 anti-influenza_Chain 5492 22-41 anti-influenza_Chain 5493 22-41 anti-influenza_Chain 5494 22-41 anti-influenza_Chain 5495 22-41 anti-influenza_Chain 5496 22-41 538-547 anti-influenza_Chain 5497 22-41 538-547 anti-influenza_Chain 5498 22-41 anti-influenza_Chain 5499 22-41 anti-influenza_Chain 5500 22-41 anti-influenza_Chain 5501 22-41 anti-influenza_Chain 5502 22-41 anti-influenza_Chain 5503 22-41 anti-influenza_Chain 5504 22-41 anti-influenza_Chain 5505 22-41 anti-influenza_Chain 5506 22-41 anti-influenza_Chain 5507 22-41 anti-influenza_Chain 5508 22-41 anti-influenza_Chain 5509 22-41 anti-influenza_Chain 5510 22-41 anti-influenza_Chain 5511 22-41 anti-influenza_Chain 5512 22-41 anti-influenza_Chain 5513 22-41 anti-influenza_Chain 5514 22-41 anti-influenza_Chain 5515 22-41 565-574 anti-influenza_Chain 5516 22-41 anti-influenza_Chain 5517 22-41 565-574 anti-influenza_Chain 5518 22-41 108-117 anti-influenza_Chain 5519 22-41 108-117 anti-influenza_Chain 5520 22-41  5-14 anti-influenza_Chain 5521 22-41  5-14 anti-influenza_Chain 5522 22-41 116-125 anti-influenza_Chain 5523 22-41 116-125 anti-influenza_Chain 5524 22-41 129-138 anti-influenza_Chain 5525 22-41 129-138 anti-influenza_Chain 5526 22-41 anti-influenza_Chain 5527 22-41 anti-influenza_Chain 5528 22-41 178-187 anti-influenza_Chain 5529 22-41 178-187 anti-influenza_Chain 5530 22-41 114-123 anti-influenza_Chain 5531 22-41 114-123 anti-influenza_Chain 5532 22-41 184-193 anti-influenza_Chain 5533 22-41 184-193 anti-influenza_Chain 5534 22-41 anti-influenza_Chain 5535 22-41 anti-influenza_Chain 5536 22-41 554-563 anti-influenza_Chain 5537 22-41 554-563 anti-influenza_Chain 5538 22-41 206-215 anti-influenza_Chain 5539 22-41 206-215 anti-0X40_LightChain 5540 22-41 48-57 86-105 anti-0X40_LightChain 5541 22-41 48-57 86-105 anti-0X40_LightChain 5542 22-41 48-57 86-105 anti-0X40_LightChain 5543 22-41 48-57 86-105 anti-0X40_LightChain 5544 22-41 48-57 anti-0X40_LightChain 5545 22-41 48-57 86-105 anti-0X40_LightChain 5546 22-41 48-57 86-105 anti-0X40_LightChain 5547 22-41 48-57 86-105 anti-0X40_LightChain 5548 22-41 48-57 86-105 anti-0X40_LightChain 5549 22-41 48-57 86-105 anti-0X40_LightChain 5550 22-41 48-57 86-105 anti-0X40_LightChain 5551 22-41 48-57 86-105 anti-0X40_LightChain 5552 22-41 48-57 86-105 anti-0X40_LightChain 5553 22-41 48-57 86-105 anti-0X40_HeavyChain 5554 22-41 94-113 anti-0X40_HeavyChain 5555 22-41 94-113 anti-0X40_HeavyChain 5556 22-41 94-113 anti-0X40_HeavyChain 5557 22-41 94-113 anti-0X40_HeavyChain 5558 22-41 94-113 anti-0X40_HeavyChain 5559 22-41 94-113 anti-0X40_HeavyChain 5560 22-41 94-113 anti-0X40_HeavyChain 5561 22-41 94-113 anti-0X40_HeavyChain 5562 22-41 94-113 anti-0X40_HeavyChain 5563 22-41 94-113 anti-0X40_HeavyChain 5564 22-41 94-113 anti-0X40_HeavyChain 5565 22-41 94-113 anti-0X40_HeavyChain 5566 22-41 94-113 anti-0X40_HeavyChain 5567 22-41 94-113 anti-0X40_HeavyChain 5568 22-41 94-113 anti-0X40_HeavyChain 5569 22-41 94-113 anti-0X40_HeavyChain 5570 22-41 93-112 anti-0X40_HeavyChain 5571 22-41 93-112 anti-0X40_HeavyChain 5572 22-41 anti-0X40_HeavyChain 5573 22-41 anti-0X40_HeavyChain 5574 22-41 anti-0X40_HeavyChain 5575 22-41 93-112 anti-0X40_HeavyChain 5576 22-41 93-112 anti-0X40_HeavyChain 5577 22-41 anti-0X40_HeavyChain 5578 22-41 anti-0X40_HeavyChain 5579 22-41 93-112 anti-0X40_HeavyChain 5580 22-41 93-112 anti-0X40_HeavyChain 5581 22-41 93-112 anti-0X40_HeavyChain 5582 22-41 93-112 anti-0X40_HeavyChain 5583 22-41 93-112 anti-0X40_HeavyChain 5584 22-41 93-112 anti-0X40_HeavyChain 5585 22-41 93-112 anti-0X40_HeavyChain 5586 22-41 anti-0X40_HeavyChain 5587 22-41 93-112 anti-0X40_HeavyChain 5588 22-41 94-113 anti-0X40_LightChain 5589 22-41 69-78 107-126  anti-0X40_LightChain 5590 22-41 68-77 106-125  anti-0X40_LightChain 5591 22-41 68-77 106-125  anti-0X40_LightChain 5592 22-41 69-78 107-126  anti-0X40_LightChain 5593 22-41 70-79 108-127  anti-0X40_HeavyChain 5594 22-41 114-133  anti-0X40_HeavyChain 5595 22-41 72-81 114-133  anti-0X40_HeavyChain 5596 22-41 77-86 113-132  anti-0X40_HeavyChain 5597 22-41 72-81 114-133  anti-0X40_HeavyChain 5598 22-41 129-148  anti-0X40_LightChain 5599 22-41 48-57 86-105 anti-0X40_HeavyChain 5600 22-41 94-113

Accordingly, it is preferred that the at least one coding sequence encodes a complementarity determining region (CDR) of an antibody. Preferably, the CDR encoded by the at least one coding sequence comprises or consists of an amino acid sequence as described in Table 5 above.

It is also preferred that the CDR encoded by the at least one coding sequence comprises or consists of an amino acid sequence as described in Table 6 below (referred to as “protein SEQ ID NO”). Particularly preferably, the at least one coding sequence comprises or consists of a nucleic acid sequence (RNA sequence) as described in Table 6 below (referred to as “RNA SEQ ID NO”).

TABLE 6 Overview over the SEQ ID NOs of the amino acid sequences of preferred exemplary CDRs and of the respective encoding RNA sequences. Protein Name SEQ ID NO: RNA SEQ ID NO: anti-HIV_VRC01_VRC02_NIH45-46_LightChain_CDR 5601 13243, 20885, 28527, 36169, 43811, 51453, 59095 anti-HIV_VRC01_HeavyChain_CDR 5602 13244, 20886, 28528, 36170, 43812, 51454, 59096 anti-HIV_3BNC60_LightChain_CDR 5603 13245, 20887, 28529, 36171, 43813, 51455, 59097 anti-HIV_3BNC60_HeavyChain_CDR 5604 13246, 20888, 28530, 36172, 43814, 51456, 59098 anti-HIV_5H/I1-BMV-D5_HeavyChain_CDR 5605 13247, 20889, 28531, 36173, 43815, 51457, 59099 anti-HIV_8ANC195_LightChain_CDR 5606 13248, 20890, 28532, 36174, 43816, 51458, 59100 anti-HIV_CH01_CH02_CH03_LightChain_CDR 5607 13249, 20891, 28533, 36175, 43817, 51459, 59101 anti-HIV_CH01_HeavyChain_CDR 5608 13250, 20892, 28534, 36176, 43818, 51460, 59102 anti-HIV_CH02_HeavyChain_CDR 5609 13251, 20893, 28535, 36177, 43819, 51461, 59103 anti-HIV_CH03_HeavyChain_CDR 5610 13252, 20894, 28536, 36178, 43820, 51462, 59104 anti-HIV_CH04_LightChain_CDR 5611 13253, 20895, 28537, 36179, 43821, 51463, 59105 anti-HIV_CH04_HeavyChain_CDR 5612 13254, 20896, 28538, 36180, 43822, 51464, 59106 anti-HIV_NIH45-46_HeavyChain_CDR 5613 13255, 20897, 28539, 36181, 43823, 51465, 59107 anti-HIV_PG16_HeavyChain_CDR 5614 13256, 20898, 28540, 36182, 43824, 51466, 59108 anti-HIV_PGT122_LightChain_CDR 5615 13257, 20899, 28541, 36183, 43825, 51467, 59109 anti-HIV_PGT122_HeavyChain_CDR 5616 13258, 20900, 28542, 36184, 43826, 51468, 59110 anti-HIV_PGT123_LightChain_CDR 5617 13259, 20901, 28543, 36185, 43827, 51469, 59111 anti-HIV_PGT123_HeavyChain_CDR 5618 13260, 20902, 28544, 36186, 43828, 51470, 59112 anti-HIV_PGT125_PGT128_LightChain_CDR 5619 13261, 20903, 28545, 36187, 43829, 51471, 59113 anti-HIV_PGT125_HeavyChain_CDR 5620 13262, 20904, 28546, 36188, 43830, 51472, 59114 anti-HIV_PGT126_PGT127_LightChain_CDR 5621 13263, 20905, 28547, 36189, 43831, 51473, 59115 anti-HIV_PGT126_HeavyChain_CDR 5622 13264, 20906, 28548, 36190, 43832, 51474, 59116 anti-HIV_PGT127_HeavyChain_CDR 5623 13265, 20907, 28549, 36191, 43833, 51475, 59117 anti-HIV_PGT128_HeavyChain_CDR 5624 13266, 20908, 28550, 36192, 43834, 51476, 59118 anti-HIV_PGT130_LightChain_CDR 5625 13267, 20909, 28551, 36193, 43835, 51477, 59119 anti-HIV_PGT130_HeavyChain_CDR 5626 13268, 20910, 28552, 36194, 43836, 51478, 59120 anti-HIV_PGT131_LightChain_CDR 5627 13269, 20911, 28553, 36195, 43837, 51479, 59121 anti-HIV_PGT131_HeavyChain_CDR 5628 13270, 20912, 28554, 36196, 43838, 51480, 59122 anti-HIV_PGT135_PGT136_PGT137_LightChain_CDR 5629 13271, 20913, 28555, 36197, 43839, 51481, 59123 anti-HIV_PGT135_HeavyChain_CDR 5630 13272, 20914, 28556, 36198, 43840, 51482, 59124 anti-HIV_PGT136_HeavyChain_CDR 5631 13273, 20915, 28557, 36199, 43841, 51483, 59125 anti-HIV_PGT137_HeavyChain_CDR 5632 13274, 20916, 28558, 36200, 43842, 51484, 59126 anti-HIV_PGT141_PGT142_PGT143_PGT144_LightChain_CDR 5633 13275, 20917, 28559, 36201, 43843, 51485, 59127 anti-HIV_PGT141_HeavyChain_CDR 5634 13276, 20918, 28560, 36202, 43844, 51486, 59128 anti-HIV_PGT144_HeavyChain_CDR 5635 13277, 20919, 28561, 36203, 43845, 51487, 59129 anti-HIV_PGT145_LightChain_CDR 5636 13278, 20920, 28562, 36204, 43846, 51488, 59130 anti-HIV_PGT145_HeavyChain_CDR 5637 13279, 20921, 28563, 36205, 43847, 51489, 59131 anti-HIV_VRC-CH30_VRC-CH31_VRC-CH32_VRC- 5638 13280, 20922, 28564, 36206, 43848, 51490, 59132 CH33_VRC-CH34_LightChain_CDR anti-HIV_VRC-CH30_VRC-CH31_VRC-CH32_VRC- 5639 13281, 20923, 28565, 36207, 43849, 51491, 59133 CH34_HeavyChain_CDR anti-HIV_VRC-CH33_HeavyChain_CDR 5640 13282, 20924, 28566, 36208, 43850, 51492, 59134 anti-HIV_VRC-PG04_LightChain_CDR 5641 13283, 20925, 28567, 36209, 43851, 51493, 59135 anti-HIV_VRC-PG04_HeavyChain_CDR 5642 13284, 20926, 28568, 36210, 43852, 51494, 59136 anti-HIV_VRC-PG04b_LightChain_CDR 5643 13285, 20927, 28569, 36211, 43853, 51495, 59137 anti-HIV_VRC-PG04b_HeavyChain_CDR 5644 13286, 20928, 28570, 36212, 43854, 51496, 59138 anti-HIV_VRC03_LightChain_CDR 5645 13287, 20929, 28571, 36213, 43855, 51497, 59139 anti-HIV_VRC03_HeavyChain_CDR 5646 13288, 20930, 28572, 36214, 43856, 51498, 59140 anti-HIV_1TJG_P-Chain 5647 13289, 20931, 28573, 36215, 43857, 51499, 59141 anti-HIV_2B1H_P-Chain 5648 13290, 20932, 28574, 36216, 43858, 51500, 59142 anti-HIV_2B1A_P-Chain 5649 13291, 20933, 28575, 36217, 43859, 51501, 59143 anti-HIV_2B0S_P-Chain 5650 13292, 20934, 28576, 36218, 43860, 51502, 59144 anti-HIV_3UJJ_P-Chain 5651 13293, 20935, 28577, 36219, 43861, 51503, 59145 anti-HIV_3UJI_P-Chain 5652 13294, 20936, 28578, 36220, 43862, 51504, 59146 anti-HIV_3MLZ_P-Chain 5653 13295, 20937, 28579, 36221, 43863, 51505, 59147 anti-HIV_3MLV_Q-Chain 5654 13296, 20938, 28580, 36222, 43864, 51506, 59148 anti-HIV_3MLU_P-Chain 5655 13297, 20939, 28581, 36223, 43865, 51507, 59149 anti-HIV_3MLR_P-Chain 5656 13298, 20940, 28582, 36224, 43866, 51508, 59150 anti-HIV_4XCF_P-Chain 5657 13299, 20941, 28583, 36225, 43867, 51509, 59151 anti-HIV_4XBE_P-Chain 5658 13300, 20942, 28584, 36226, 43868, 51510, 59152 anti-HIV_4XAW_P-Chain 5659 13301, 20943, 28585, 36227, 43869, 51511, 59153 anti-HIV_2QSC_P-Chain 5660 13302, 20944, 28586, 36228, 43870, 51512, 59154 anti-HIV_3MLS_S-Chain 5661 13303, 20945, 28587, 36229, 43871, 51513, 59155 anti-HIV_3G01_P-Chain 5662 13304, 20946, 28588, 36230, 43872, 51514, 59156 anti-HIV_4MID_Q-Chain 5663 13305, 20947, 28589, 36231, 43873, 51515, 59157 anti-HIV_3C2A_Q-Chain 5664 13306, 20948, 28590, 36232, 43874, 51516, 59158 anti-HIV_CDR 5665 13307, 20949, 28591, 36233, 43875, 51517, 59159 anti-HIV_CDR 5666 13308, 20950, 28592, 36234, 43876, 51518, 59160 anti-HIV_CDR 5667 13309, 20951, 28593, 36235, 43877, 51519, 59161 anti-HIV_CDR 5668 13310, 20952, 28594, 36236, 43878, 51520, 59162 anti-HIV_CDR 5669 13311, 20953, 28595, 36237, 43879, 51521, 59163 anti-HIV_CDR 5670 13312, 20954, 28596, 36238, 43880, 51522, 59164 anti-HIV_CDR 5671 13313, 20955, 28597, 36239, 43881, 51523, 59165 anti-HIV_CDR 5672 13314, 20956, 28598, 36240, 43882, 51524, 59166 anti-HIV_CDR 5673 13315, 20957, 28599, 36241, 43883, 51525, 59167 anti-HIV_CDR 5674 13316, 20958, 28600, 36242, 43884, 51526, 59168 anti-HIV_CDR 5675 13317, 20959, 28601, 36243, 43885, 51527, 59169 anti-HIV_CDR 5676 13318, 20960, 28602, 36244, 43886, 51528, 59170 anti-HIV_CDR 5677 13319, 20961, 28603, 36245, 43887, 51529, 59171 anti-HIV_CDR 5678 13320, 20962, 28604, 36246, 43888, 51530, 59172 anti-HIV_CDR 5679 13321, 20963, 28605, 36247, 43889, 51531, 59173 anti-HIV_CDR 5680 13322, 20964, 28606, 36248, 43890, 51532, 59174 anti-HIV_CDR 5681 13323, 20965, 28607, 36249, 43891, 51533, 59175 anti-HIV_CDR 5682 13324, 20966, 28608, 36250, 43892, 51534, 59176 anti-HIV_CDR 5683 13325, 20967, 28609, 36251, 43893, 51535, 59177 anti-HIV_CDR 5684 13326, 20968, 28610, 36252, 43894, 51536, 59178 anti-HIV_CDR 5685 13327, 20969, 28611, 36253, 43895, 51537, 59179 anti-HIV_CDR 5686 13328, 20970, 28612, 36254, 43896, 51538, 59180 anti-HIV_CDR 5687 13329, 20971, 28613, 36255, 43897, 51539, 59181 anti-HIV_CDR 5688 13330, 20972, 28614, 36256, 43898, 51540, 59182 anti-HIV_CDR 5689 13331, 20973, 28615, 36257, 43899, 51541, 59183 anti-HIV_CDR 5690 13332, 20974, 28616, 36258, 43900, 51542, 59184 anti-HIV_CDR 5691 13333, 20975, 28617, 36259, 43901, 51543, 59185 anti-HIV_CDR 5692 13334, 20976, 28618, 36260, 43902, 51544, 59186 anti-HIV_CDR 5693 13335, 20977, 28619, 36261, 43903, 51545, 59187 anti-HIV_CDR 5694 13336, 20978, 28620, 36262, 43904, 51546, 59188 anti-HIV_CDR 5695 13337, 20979, 28621, 36263, 43905, 51547, 59189 anti-HIV_CDR 5696 13338, 20980, 28622, 36264, 43906, 51548, 59190 anti-HIV_CDR 5697 13339, 20981, 28623, 36265, 43907, 51549, 59191 anti-HIV_CDR 5698 13340, 20982, 28624, 36266, 43908, 51550, 59192 anti-HIV_CDR 5699 13341, 20983, 28625, 36267, 43909, 51551, 59193 anti-HIV_CDR 5700 13342, 20984, 28626, 36268, 43910, 51552, 59194 anti-HIV_CDR 5701 13343, 20985, 28627, 36269, 43911, 51553, 59195 anti-HIV_CDR 5702 13344, 20986, 28628, 36270, 43912, 51554, 59196 anti-HIV_CDR 5703 13345, 20987, 28629, 36271, 43913, 51555, 59197 anti-HIV_CDR 5704 13346, 20988, 28630, 36272, 43914, 51556, 59198 anti-HIV_CDR 5705 13347, 20989, 28631, 36273, 43915, 51557, 59199 anti-HIV_CDR 5706 13348, 20990, 28632, 36274, 43916, 51558, 59200 anti-HIV_CDR 5707 13349, 20991, 28633, 36275, 43917, 51559, 59201 anti-HIV_CDR 5708 13350, 20992, 28634, 36276, 43918, 51560, 59202 anti-HIV_CDR 5709 13351, 20993, 28635, 36277, 43919, 51561, 59203 anti-HIV_CDR 5710 13352, 20994, 28636, 36278, 43920, 51562, 59204 anti-HIV_CDR 5711 13353, 20995, 28637, 36279, 43921, 51563, 59205 anti-HIV_CDR 5712 13354, 20996, 28638, 36280, 43922, 51564, 59206 anti-HIV_CDR 5713 13355, 20997, 28639, 36281, 43923, 51565, 59207 anti-HIV_CDR 5714 13356, 20998, 28640, 36282, 43924, 51566, 59208 anti-HIV_CDR 5715 13357, 20999, 28641, 36283, 43925, 51567, 59209 anti-HIV_CDR 5716 13358, 21000, 28642, 36284, 43926, 51568, 59210 anti-HIV_CDR 5717 13359, 21001, 28643, 36285, 43927, 51569, 59211 anti-HIV_CDR 5718 13360, 21002, 28644, 36286, 43928, 51570, 59212 anti-HIV_CDR 5719 13361, 21003, 28645, 36287, 43929, 51571, 59213 anti-HIV_CDR 5720 13362, 21004, 28646, 36288, 43930, 51572, 59214 anti-HIV_CDR 5721 13363, 21005, 28647, 36289, 43931, 51573, 59215 anti-HIV_CDR 5722 13364, 21006, 28648, 36290, 43932, 51574, 59216 anti-HIV_CDR 5723 13365, 21007, 28649, 36291, 43933, 51575, 59217 anti-HIV_CDR 5724 13366, 21008, 28650, 36292, 43934, 51576, 59218 anti-HIV_CDR 5725 13367, 21009, 28651, 36293, 43935, 51577, 59219 anti-HIV_CDR 5726 13368, 21010, 28652, 36294, 43936, 51578, 59220 anti-HIV_CDR 5727 13369, 21011, 28653, 36295, 43937, 51579, 59221 anti-HIV_CDR 5728 13370, 21012, 28654, 36296, 43938, 51580, 59222 anti-HIV_CDR 5729 13371, 21013, 28655, 36297, 43939, 51581, 59223 anti-HIV_CDR 5730 13372, 21014, 28656, 36298, 43940, 51582, 59224 anti-HIV_CDR 5731 13373, 21015, 28657, 36299, 43941, 51583, 59225 anti-HIV_CDR 5732 13374, 21016, 28658, 36300, 43942, 51584, 59226 anti-HIV_CDR 5733 13375, 21017, 28659, 36301, 43943, 51585, 59227 anti-HIV_CDR 5734 13376, 21018, 28660, 36302, 43944, 51586, 59228 anti-HIV_CDR 5735 13377, 21019, 28661, 36303, 43945, 51587, 59229 anti-HIV_CDR 5736 13378, 21020, 28662, 36304, 43946, 51588, 59230 anti-HIV_CDR 5737 13379, 21021, 28663, 36305, 43947, 51589, 59231 anti-HIV_CDR 5738 13380, 21022, 28664, 36306, 43948, 51590, 59232 anti-HIV_CDR 5739 13381, 21023, 28665, 36307, 43949, 51591, 59233 anti-HIV_CDR 5740 13382, 21024, 28666, 36308, 43950, 51592, 59234 anti-HIV_CDR 5741 13383, 21025, 28667, 36309, 43951, 51593, 59235 anti-HIV_CDR 5742 13384, 21026, 28668, 36310, 43952, 51594, 59236 anti-HIV_CDR 5743 13385, 21027, 28669, 36311, 43953, 51595, 59237 anti-HIV_CDR 5744 13386, 21028, 28670, 36312, 43954, 51596, 59238 anti-HIV_CDR 5745 13387, 21029, 28671, 36313, 43955, 51597, 59239 anti-HIV_CDR 5746 13388, 21030, 28672, 36314, 43956, 51598, 59240 anti-HIV_CDR 5747 13389, 21031, 28673, 36315, 43957, 51599, 59241 anti-HIV_CDR 5748 13390, 21032, 28674, 36316, 43958, 51600, 59242 anti-HIV_CDR 5749 13391, 21033, 28675, 36317, 43959, 51601, 59243 anti-HIV_CDR 5750 13392, 21034, 28676, 36318, 43960, 51602, 59244 anti-HIV_CDR 5751 13393, 21035, 28677, 36319, 43961, 51603, 59245 anti-HIV_CDR 5752 13394, 21036, 28678, 36320, 43962, 51604, 59246 anti-HIV_CDR 5753 13395, 21037, 28679, 36321, 43963, 51605, 59247 anti-HIV_CDR 5754 13396, 21038, 28680, 36322, 43964, 51606, 59248 anti-HIV_CDR 5755 13397, 21039, 28681, 36323, 43965, 51607, 59249 anti-HIV_CDR 5756 13398, 21040, 28682, 36324, 43966, 51608, 59250 anti-HIV_CDR 5757 13399, 21041, 28683, 36325, 43967, 51609, 59251 anti-HIV_CDR 5758 13400, 21042, 28684, 36326, 43968, 51610, 59252 anti-HIV_CDR 5759 13401, 21043, 28685, 36327, 43969, 51611, 59253 anti-HIV_CDR 5760 13402, 21044, 28686, 36328, 43970, 51612, 59254 anti-HIV_CDR 5761 13403, 21045, 28687, 36329, 43971, 51613, 59255 anti-HIV_CDR 5762 13404, 21046, 28688, 36330, 43972, 51614, 59256 anti-HIV_CDR 5763 13405, 21047, 28689, 36331, 43973, 51615, 59257 anti-HIV_CDR 5764 13406, 21048, 28690, 36332, 43974, 51616, 59258 anti-HIV_CDR 5765 13407, 21049, 28691, 36333, 43975, 51617, 59259 anti-HIV_CDR 5766 13408, 21050, 28692, 36334, 43976, 51618, 59260 anti-HIV_CDR 5767 13409, 21051, 28693, 36335, 43977, 51619, 59261 anti-HIV_CDR 5768 13410, 21052, 28694, 36336, 43978, 51620, 59262 anti-HIV_CDR 5769 13411, 21053, 28695, 36337, 43979, 51621, 59263 anti-HIV_CDR 5770 13412, 21054, 28696, 36338, 43980, 51622, 59264 anti-HIV_CDR 5771 13413, 21055, 28697, 36339, 43981, 51623, 59265 anti-HIV_CDR 5772 13414, 21056, 28698, 36340, 43982, 51624, 59266 anti-HIV_CDR 5773 13415, 21057, 28699, 36341, 43983, 51625, 59267 anti-HIV_CDR 5774 13416, 21058, 28700, 36342, 43984, 51626, 59268 anti-HIV_CDR 5775 13417, 21059, 28701, 36343, 43985, 51627, 59269 anti-HIV_CDR 5776 13418, 21060, 28702, 36344, 43986, 51628, 59270 anti-HIV_CDR 5777 13419, 21061, 28703, 36345, 43987, 51629, 59271 anti-HIV_CDR 5778 13420, 21062, 28704, 36346, 43988, 51630, 59272 anti-HIV_CDR 5779 13421, 21063, 28705, 36347, 43989, 51631, 59273 anti-HIV_CDR 5780 13422, 21064, 28706, 36348, 43990, 51632, 59274 anti-HIV_CDR 5781 13423, 21065, 28707, 36349, 43991, 51633, 59275 anti-HIV_CDR 5782 13424, 21066, 28708, 36350, 43992, 51634, 59276 anti-HIV_CDR 5783 13425, 21067, 28709, 36351, 43993, 51635, 59277 anti-HIV_CDR 5784 13426, 21068, 28710, 36352, 43994, 51636, 59278 anti-HIV_CDR 5785 13427, 21069, 28711, 36353, 43995, 51637, 59279 anti-HIV_CDR 5786 13428, 21070, 28712, 36354, 43996, 51638, 59280 anti-HIV_CDR 5787 13429, 21071, 28713, 36355, 43997, 51639, 59281 anti-HIV_CDR 5788 13430, 21072, 28714, 36356, 43998, 51640, 59282 anti-HIV_CDR 5789 13431, 21073, 28715, 36357, 43999, 51641, 59283 anti-HIV_CDR 5790 13432, 21074, 28716, 36358, 44000, 51642, 59284 anti-HIV_CDR 5791 13433, 21075, 28717, 36359, 44001, 51643, 59285 anti-HIV_CDR 5792 13434, 21076, 28718, 36360, 44002, 51644, 59286 anti-HIV_CDR 5793 13435, 21077, 28719, 36361, 44003, 51645, 59287 anti-HIV_CDR 5794 13436, 21078, 28720, 36362, 44004, 51646, 59288 anti-HIV_CDR 5795 13437, 21079, 28721, 36363, 44005, 51647, 59289 anti-HIV_CDR 5796 13438, 21080, 28722, 36364, 44006, 51648, 59290 anti-HIV_CDR 5797 13439, 21081, 28723, 36365, 44007, 51649, 59291 anti-HIV_CDR 5798 13440, 21082, 28724, 36366, 44008, 51650, 59292 anti-HIV_CDR 5799 13441, 21083, 28725, 36367, 44009, 51651, 59293 anti-HIV_CDR 5800 13442, 21084, 28726, 36368, 44010, 51652, 59294 anti-HIV_CDR 5801 13443, 21085, 28727, 36369, 44011, 51653, 59295 anti-HIV_CDR 5802 13444, 21086, 28728, 36370, 44012, 51654, 59296 anti-HIV_CDR 5803 13445, 21087, 28729, 36371, 44013, 51655, 59297 anti-HIV_CDR 5804 13446, 21088, 28730, 36372, 44014, 51656, 59298 anti-HIV_CDR 5805 13447, 21089, 28731, 36373, 44015, 51657, 59299 anti-HIV_CDR 5806 13448, 21090, 28732, 36374, 44016, 51658, 59300 anti-HIV_CDR 5807 13449, 21091, 28733, 36375, 44017, 51659, 59301 anti-HIV_CDR 5808 13450, 21092, 28734, 36376, 44018, 51660, 59302 anti-HIV_CDR 5809 13451, 21093, 28735, 36377, 44019, 51661, 59303 anti-HIV_CDR 5810 13452, 21094, 28736, 36378, 44020, 51662, 59304 anti-HIV_CDR 5811 13453, 21095, 28737, 36379, 44021, 51663, 59305 anti-HIV_CDR 5812 13454, 21096, 28738, 36380, 44022, 51664, 59306 anti-HIV_CDR 5813 13455, 21097, 28739, 36381, 44023, 51665, 59307 anti-HIV_CDR 5814 13456, 21098, 28740, 36382, 44024, 51666, 59308 anti-HIV_CDR 5815 13457, 21099, 28741, 36383, 44025, 51667, 59309 anti-HIV_CDR 5816 13458, 21100, 28742, 36384, 44026, 51668, 59310 anti-HIV_CDR 5817 13459, 21101, 28743, 36385, 44027, 51669, 59311 anti-HIV_CDR 5818 13460, 21102, 28744, 36386, 44028, 51670, 59312 anti-HIV_CDR 5819 13461, 21103, 28745, 36387, 44029, 51671, 59313 anti-HIV_CDR 5820 13462, 21104, 28746, 36388, 44030, 51672, 59314 anti-HIV_CDR 5821 13463, 21105, 28747, 36389, 44031, 51673, 59315 anti-HIV_CDR 5822 13464, 21106, 28748, 36390, 44032, 51674, 59316 anti-HIV_CDR 5823 13465, 21107, 28749, 36391, 44033, 51675, 59317 anti-HIV_CDR 5824 13466, 21108, 28750, 36392, 44034, 51676, 59318 anti-HIV_CDR 5825 13467, 21109, 28751, 36393, 44035, 51677, 59319 anti-HIV_CDR 5826 13468, 21110, 28752, 36394, 44036, 51678, 59320 anti-HIV_CDR 5827 13469, 21111, 28753, 36395, 44037, 51679, 59321 anti-HIV_CDR 5828 13470, 21112, 28754, 36396, 44038, 51680, 59322 anti-HIV_CDR 5829 13471, 21113, 28755, 36397, 44039, 51681, 59323 anti-HIV_CDR 5830 13472, 21114, 28756, 36398, 44040, 51682, 59324 anti-HIV_CDR 5831 13473, 21115, 28757, 36399, 44041, 51683, 59325 anti-HIV_CDR 5832 13474, 21116, 28758, 36400, 44042, 51684, 59326 anti-HIV_CDR 5833 13475, 21117, 28759, 36401, 44043, 51685, 59327 anti-HIV_CDR 5834 13476, 21118, 28760, 36402, 44044, 51686, 59328 anti-HIV_CDR 5835 13477, 21119, 28761, 36403, 44045, 51687, 59329 anti-HIV_CDR 5836 13478, 21120, 28762, 36404, 44046, 51688, 59330 anti-HIV_CDR 5837 13479, 21121, 28763, 36405, 44047, 51689, 59331 anti-HIV_CDR 5838 13480, 21122, 28764, 36406, 44048, 51690, 59332 anti-HIV_CDR 5839 13481, 21123, 28765, 36407, 44049, 51691, 59333 anti-HIV_CDR 5840 13482, 21124, 28766, 36408, 44050, 51692, 59334 anti-HIV_CDR 5841 13483, 21125, 28767, 36409, 44051, 51693, 59335 anti-HIV_CDR 5842 13484, 21126, 28768, 36410, 44052, 51694, 59336 anti-HIV_CDR 5843 13485, 21127, 28769, 36411, 44053, 51695, 59337 anti-HIV_CDR 5844 13486, 21128, 28770, 36412, 44054, 51696, 59338 anti-HIV_CDR 5845 13487, 21129, 28771, 36413, 44055, 51697, 59339 anti-HIV_CDR 5846 13488, 21130, 28772, 36414, 44056, 51698, 59340 anti-HIV_CDR 5847 13489, 21131, 28773, 36415, 44057, 51699, 59341 anti-HIV_CDR 5848 13490, 21132, 28774, 36416, 44058, 51700, 59342 anti-HIV_CDR 5849 13491, 21133, 28775, 36417, 44059, 51701, 59343 anti-HIV_CDR 5850 13492, 21134, 28776, 36418, 44060, 51702, 59344 anti-HIV_CDR 5851 13493, 21135, 28777, 36419, 44061, 51703, 59345 anti-HIV_CDR 5852 13494, 21136, 28778, 36420, 44062, 51704, 59346 anti-HIV_CDR 5853 13495, 21137, 28779, 36421, 44063, 51705, 59347 anti-HIV_CDR 5854 13496, 21138, 28780, 36422, 44064, 51706, 59348 anti-HIV_CDR 5855 13497, 21139, 28781, 36423, 44065, 51707, 59349 anti-HIV_CDR 5856 13498, 21140, 28782, 36424, 44066, 51708, 59350 anti-HIV_CDR 5857 13499, 21141, 28783, 36425, 44067, 51709, 59351 anti-HIV_CDR 5858 13500, 21142, 28784, 36426, 44068, 51710, 59352 anti-HIV_CDR 5859 13501, 21143, 28785, 36427, 44069, 51711, 59353 anti-HIV_CDR 5860 13502, 21144, 28786, 36428, 44070, 51712, 59354 anti-HIV_CDR 5861 13503, 21145, 28787, 36429, 44071, 51713, 59355 anti-HIV_CDR 5862 13504, 21146, 28788, 36430, 44072, 51714, 59356 anti-HIV_CDR 5863 13505, 21147, 28789, 36431, 44073, 51715, 59357 anti-HIV_CDR 5864 13506, 21148, 28790, 36432, 44074, 51716, 59358 anti-HIV_CDR 5865 13507, 21149, 28791, 36433, 44075, 51717, 59359 anti-HIV_CDR 5866 13508, 21150, 28792, 36434, 44076, 51718, 59360 anti-HIV_CDR 5867 13509, 21151, 28793, 36435, 44077, 51719, 59361 anti-HIV_CDR 5868 13510, 21152, 28794, 36436, 44078, 51720, 59362 anti-HIV_CDR 5869 13511, 21153, 28795, 36437, 44079, 51721, 59363 anti-HIV_CDR 5870 13512, 21154, 28796, 36438, 44080, 51722, 59364 anti-HIV_CDR 5871 13513, 21155, 28797, 36439, 44081, 51723, 59365 anti-HIV_CDR 5872 13514, 21156, 28798, 36440, 44082, 51724, 59366 anti-HIV_CDR 5873 13515, 21157, 28799, 36441, 44083, 51725, 59367 anti-HIV_CDR 5874 13516, 21158, 28800, 36442, 44084, 51726, 59368 anti-HIV_CDR 5875 13517, 21159, 28801, 36443, 44085, 51727, 59369 anti-HIV_CDR 5876 13518, 21160, 28802, 36444, 44086, 51728, 59370 anti-HIV_CDR 5877 13519, 21161, 28803, 36445, 44087, 51729, 59371 anti-HIV_CDR 5878 13520, 21162, 28804, 36446, 44088, 51730, 59372 anti-HIV_CDR 5879 13521, 21163, 28805, 36447, 44089, 51731, 59373 anti-HIV_CDR 5880 13522, 21164, 28806, 36448, 44090, 51732, 59374 anti-HIV_CDR 5881 13523, 21165, 28807, 36449, 44091, 51733, 59375 anti-HIV_CDR 5882 13524, 21166, 28808, 36450, 44092, 51734, 59376 anti-HIV_CDR 5883 13525, 21167, 28809, 36451, 44093, 51735, 59377 anti-HIV_CDR 5884 13526, 21168, 28810, 36452, 44094, 51736, 59378 anti-HIV_CDR 5885 13527, 21169, 28811, 36453, 44095, 51737, 59379 anti-HIV_CDR 5886 13528, 21170, 28812, 36454, 44096, 51738, 59380 anti-HIV_CDR 5887 13529, 21171, 28813, 36455, 44097, 51739, 59381 anti-HIV_CDR 5888 13530, 21172, 28814, 36456, 44098, 51740, 59382 anti-HIV_CDR 5889 13531, 21173, 28815, 36457, 44099, 51741, 59383 anti-HIV_CDR 5890 13532, 21174, 28816, 36458, 44100, 51742, 59384 anti-HIV_CDR 5891 13533, 21175, 28817, 36459, 44101, 51743, 59385 anti-HIV_CDR 5892 13534, 21176, 28818, 36460, 44102, 51744, 59386 anti-HIV_CDR 5893 13535, 21177, 28819, 36461, 44103, 51745, 59387 anti-HIV_CDR 5894 13536, 21178, 28820, 36462, 44104, 51746, 59388 anti-HIV_CDR 5895 13537, 21179, 28821, 36463, 44105, 51747, 59389 anti-HIV_CDR 5896 13538, 21180, 28822, 36464, 44106, 51748, 59390 anti-HIV_CDR 5897 13539, 21181, 28823, 36465, 44107, 51749, 59391 anti-HIV_CDR 5898 13540, 21182, 28824, 36466, 44108, 51750, 59392 anti-HIV_CDR 5899 13541, 21183, 28825, 36467, 44109, 51751, 59393 anti-HIV_CDR 5900 13542, 21184, 28826, 36468, 44110, 51752, 59394 anti-HIV_CDR 5901 13543, 21185, 28827, 36469, 44111, 51753, 59395 anti-HIV_CDR 5902 13544, 21186, 28828, 36470, 44112, 51754, 59396 anti-HIV_CDR 5903 13545, 21187, 28829, 36471, 44113, 51755, 59397 anti-HIV_CDR 5904 13546, 21188, 28830, 36472, 44114, 51756, 59398 anti-HIV_CDR 5905 13547, 21189, 28831, 36473, 44115, 51757, 59399 anti-HIV_CDR 5906 13548, 21190, 28832, 36474, 44116, 51758, 59400 anti-HIV_CDR 5907 13549, 21191, 28833, 36475, 44117, 51759, 59401 anti-HIV_CDR 5908 13550, 21192, 28834, 36476, 44118, 51760, 59402 anti-HIV_CDR 5909 13551, 21193, 28835, 36477, 44119, 51761, 59403 anti-HIV_CDR 5910 13552, 21194, 28836, 36478, 44120, 51762, 59404 anti-HIV_CDR 5911 13553, 21195, 28837, 36479, 44121, 51763, 59405 anti-HIV_CDR 5912 13554, 21196, 28838, 36480, 44122, 51764, 59406 anti-HIV_CDR 5913 13555, 21197, 28839, 36481, 44123, 51765, 59407 anti-HIV_CDR 5914 13556, 21198, 28840, 36482, 44124, 51766, 59408 anti-HIV_CDR 5915 13557, 21199, 28841, 36483, 44125, 51767, 59409 anti-HIV_CDR 5916 13558, 21200, 28842, 36484, 44126, 51768, 59410 anti-HIV_CDR 5917 13559, 21201, 28843, 36485, 44127, 51769, 59411 anti-HIV_CDR 5918 13560, 21202, 28844, 36486, 44128, 51770, 59412 anti-HIV_CDR 5919 13561, 21203, 28845, 36487, 44129, 51771, 59413 anti-HIV_CDR 5920 13562, 21204, 28846, 36488, 44130, 51772, 59414 anti-HIV_CDR 5921 13563, 21205, 28847, 36489, 44131, 51773, 59415 anti-HIV_CDR 5922 13564, 21206, 28848, 36490, 44132, 51774, 59416 anti-HIV_CDR 5923 13565, 21207, 28849, 36491, 44133, 51775, 59417 anti-HIV_CDR 5924 13566, 21208, 28850, 36492, 44134, 51776, 59418 anti-HIV_CDR 5925 13567, 21209, 28851, 36493, 44135, 51777, 59419 anti-HIV_CDR 5926 13568, 21210, 28852, 36494, 44136, 51778, 59420 anti-HIV_CDR 5927 13569, 21211, 28853, 36495, 44137, 51779, 59421 anti-HIV_CDR 5928 13570, 21212, 28854, 36496, 44138, 51780, 59422 anti-HIV_CDR 5929 13571, 21213, 28855, 36497, 44139, 51781, 59423 anti-HIV_CDR 5930 13572, 21214, 28856, 36498, 44140, 51782, 59424 anti-HIV_CDR 5931 13573, 21215, 28857, 36499, 44141, 51783, 59425 anti-HIV_CDR 5932 13574, 21216, 28858, 36500, 44142, 51784, 59426 anti-HIV_CDR 5933 13575, 21217, 28859, 36501, 44143, 51785, 59427 anti-HIV_CDR 5934 13576, 21218, 28860, 36502, 44144, 51786, 59428 anti-HIV_CDR 5935 13577, 21219, 28861, 36503, 44145, 51787, 59429 anti-HIV_CDR 5936 13578, 21220, 28862, 36504, 44146, 51788, 59430 anti-HIV_CDR 5937 13579, 21221, 28863, 36505, 44147, 51789, 59431 anti-HIV_CDR 5938 13580, 21222, 28864, 36506, 44148, 51790, 59432 anti-HIV_CDR 5939 13581, 21223, 28865, 36507, 44149, 51791, 59433 anti-HIV_CDR 5940 13582, 21224, 28866, 36508, 44150, 51792, 59434 anti-HIV_CDR 5941 13583, 21225, 28867, 36509, 44151, 51793, 59435 anti-HIV_CDR 5942 13584, 21226, 28868, 36510, 44152, 51794, 59436 anti-HIV_CDR 5943 13585, 21227, 28869, 36511, 44153, 51795, 59437 anti-HIV_CDR 5944 13586, 21228, 28870, 36512, 44154, 51796, 59438 anti-HIV_CDR 5945 13587, 21229, 28871, 36513, 44155, 51797, 59439 anti-HIV_CDR 5946 13588, 21230, 28872, 36514, 44156, 51798, 59440 anti-HIV_CDR 5947 13589, 21231, 28873, 36515, 44157, 51799, 59441 anti-HIV_CDR 5948 13590, 21232, 28874, 36516, 44158, 51800, 59442 anti-HIV_CDR 5949 13591, 21233, 28875, 36517, 44159, 51801, 59443 anti-HIV_CDR 5950 13592, 21234, 28876, 36518, 44160, 51802, 59444 anti-HIV_CDR 5951 13593, 21235, 28877, 36519, 44161, 51803, 59445 anti-HIV_CDR 5952 13594, 21236, 28878, 36520, 44162, 51804, 59446 anti-HIV_CDR 5953 13595, 21237, 28879, 36521, 44163, 51805, 59447 anti-HIV_CDR 5954 13596, 21238, 28880, 36522, 44164, 51806, 59448 anti-HIV_CDR 5955 13597, 21239, 28881, 36523, 44165, 51807, 59449 anti-HIV_CDR 5956 13598, 21240, 28882, 36524, 44166, 51808, 59450 anti-HIV_CDR 5957 13599, 21241, 28883, 36525, 44167, 51809, 59451 anti-HIV_CDR 5958 13600, 21242, 28884, 36526, 44168, 51810, 59452 anti-HIV_CDR 5959 13601, 21243, 28885, 36527, 44169, 51811, 59453 anti-HIV_CDR 5960 13602, 21244, 28886, 36528, 44170, 51812, 59454 anti-HIV_CDR 5961 13603, 21245, 28887, 36529, 44171, 51813, 59455 anti-HIV_CDR 5962 13604, 21246, 28888, 36530, 44172, 51814, 59456 anti-HIV_CDR 5963 13605, 21247, 28889, 36531, 44173, 51815, 59457 anti-HIV_CDR 5964 13606, 21248, 28890, 36532, 44174, 51816, 59458 anti-HIV_CDR 5965 13607, 21249, 28891, 36533, 44175, 51817, 59459 anti-HIV_CDR 5966 13608, 21250, 28892, 36534, 44176, 51818, 59460 anti-HIV_CDR 5967 13609, 21251, 28893, 36535, 44177, 51819, 59461 anti-HIV_CDR 5968 13610, 21252, 28894, 36536, 44178, 51820, 59462 anti-HIV_CDR 5969 13611, 21253, 28895, 36537, 44179, 51821, 59463 anti-HIV_CDR 5970 13612, 21254, 28896, 36538, 44180, 51822, 59464 anti-HIV_CDR 5971 13613, 21255, 28897, 36539, 44181, 51823, 59465 anti-HIV_CDR 5972 13614, 21256, 28898, 36540, 44182, 51824, 59466 anti-HIV_CDR 5973 13615, 21257, 28899, 36541, 44183, 51825, 59467 anti-HIV_CDR 5974 13616, 21258, 28900, 36542, 44184, 51826, 59468 anti-HIV_CDR 5975 13617, 21259, 28901, 36543, 44185, 51827, 59469 anti-HIV_CDR 5976 13618, 21260, 28902, 36544, 44186, 51828, 59470 anti-HIV_CDR 5977 13619, 21261, 28903, 36545, 44187, 51829, 59471 anti-HIV_CDR 5978 13620, 21262, 28904, 36546, 44188, 51830, 59472 anti-HIV_CDR 5979 13621, 21263, 28905, 36547, 44189, 51831, 59473 anti-HIV_CDR 5980 13622, 21264, 28906, 36548, 44190, 51832, 59474 anti-HIV_CDR 5981 13623, 21265, 28907, 36549, 44191, 51833, 59475 anti-HIV_CDR 5982 13624, 21266, 28908, 36550, 44192, 51834, 59476 anti-HIV_CDR 5983 13625, 21267, 28909, 36551, 44193, 51835, 59477 anti-HIV_CDR 5984 13626, 21268, 28910, 36552, 44194, 51836, 59478 anti-HIV_CDR 5985 13627, 21269, 28911, 36553, 44195, 51837, 59479 anti-HIV_CDR 5986 13628, 21270, 28912, 36554, 44196, 51838, 59480 anti-HIV_CDR 5987 13629, 21271, 28913, 36555, 44197, 51839, 59481 anti-HIV_CDR 5988 13630, 21272, 28914, 36556, 44198, 51840, 59482 anti-HIV_CDR 5989 13631, 21273, 28915, 36557, 44199, 51841, 59483 anti-HIV_CDR 5990 13632, 21274, 28916, 36558, 44200, 51842, 59484 anti-HIV_CDR 5991 13633, 21275, 28917, 36559, 44201, 51843, 59485 anti-HIV_CDR 5992 13634, 21276, 28918, 36560, 44202, 51844, 59486 anti-HIV_CDR 5993 13635, 21277, 28919, 36561, 44203, 51845, 59487 anti-HIV_CDR 5994 13636, 21278, 28920, 36562, 44204, 51846, 59488 anti-HIV_CDR 5995 13637, 21279, 28921, 36563, 44205, 51847, 59489 anti-HIV_CDR 5996 13638, 21280, 28922, 36564, 44206, 51848, 59490 anti-HIV_CDR 5997 13639, 21281, 28923, 36565, 44207, 51849, 59491 anti-HIV_CDR 5998 13640, 21282, 28924, 36566, 44208, 51850, 59492 anti-HIV_CDR 5999 13641, 21283, 28925, 36567, 44209, 51851, 59493 anti-HIV_CDR 6000 13642, 21284, 28926, 36568, 44210, 51852, 59494 anti-HIV_CDR 6001 13643, 21285, 28927, 36569, 44211, 51853, 59495 anti-HIV_CDR 6002 13644, 21286, 28928, 36570, 44212, 51854, 59496 anti-HIV_CDR 6003 13645, 21287, 28929, 36571, 44213, 51855, 59497 anti-HIV_CDR 6004 13646, 21288, 28930, 36572, 44214, 51856, 59498 anti-HIV_CDR 6005 13647, 21289, 28931, 36573, 44215, 51857, 59499 anti-HIV_CDR 6006 13648, 21290, 28932, 36574, 44216, 51858, 59500 anti-HIV_CDR 6007 13649, 21291, 28933, 36575, 44217, 51859, 59501 anti-HIV_CDR 6008 13650, 21292, 28934, 36576, 44218, 51860, 59502 anti-HIV_CDR 6009 13651, 21293, 28935, 36577, 44219, 51861, 59503 anti-HIV_CDR 6010 13652, 21294, 28936, 36578, 44220, 51862, 59504 anti-HIV_CDR 6011 13653, 21295, 28937, 36579, 44221, 51863, 59505 anti-HIV_CDR 6012 13654, 21296, 28938, 36580, 44222, 51864, 59506 anti-HIV_CDR 6013 13655, 21297, 28939, 36581, 44223, 51865, 59507 anti-HIV_CDR 6014 13656, 21298, 28940, 36582, 44224, 51866, 59508 anti-HIV_CDR 6015 13657, 21299, 28941, 36583, 44225, 51867, 59509 anti-HIV_CDR 6016 13658, 21300, 28942, 36584, 44226, 51868, 59510 anti-HIV_CDR 6017 13659, 21301, 28943, 36585, 44227, 51869, 59511 anti-HIV_CDR 6018 13660, 21302, 28944, 36586, 44228, 51870, 59512 anti-HIV_CDR 6019 13661, 21303, 28945, 36587, 44229, 51871, 59513 anti-HIV_CDR 6020 13662, 21304, 28946, 36588, 44230, 51872, 59514 anti-HIV_CDR 6021 13663, 21305, 28947, 36589, 44231, 51873, 59515 anti-HIV_CDR 6022 13664, 21306, 28948, 36590, 44232, 51874, 59516 anti-HIV_CDR 6023 13665, 21307, 28949, 36591, 44233, 51875, 59517 anti-HIV_CDR 6024 13666, 21308, 28950, 36592, 44234, 51876, 59518 anti-HIV_CDR 6025 13667, 21309, 28951, 36593, 44235, 51877, 59519 anti-HIV_CDR 6026 13668, 21310, 28952, 36594, 44236, 51878, 59520 anti-HIV_CDR 6027 13669, 21311, 28953, 36595, 44237, 51879, 59521 anti-HIV_CDR 6028 13670, 21312, 28954, 36596, 44238, 51880, 59522 anti-HIV_CDR 6029 13671, 21313, 28955, 36597, 44239, 51881, 59523 anti-HIV_CDR 6030 13672, 21314, 28956, 36598, 44240, 51882, 59524 anti-HIV_CDR 6031 13673, 21315, 28957, 36599, 44241, 51883, 59525 anti-HIV_CDR 6032 13674, 21316, 28958, 36600, 44242, 51884, 59526 anti-HIV_CDR 6033 13675, 21317, 28959, 36601, 44243, 51885, 59527 anti-HIV_CDR 6034 13676, 21318, 28960, 36602, 44244, 51886, 59528 anti-HIV_CDR 6035 13677, 21319, 28961, 36603, 44245, 51887, 59529 anti-HIV_CDR 6036 13678, 21320, 28962, 36604, 44246, 51888, 59530 anti-HIV_CDR 6037 13679, 21321, 28963, 36605, 44247, 51889, 59531 anti-HIV_CDR 6038 13680, 21322, 28964, 36606, 44248, 51890, 59532 anti-HIV_CDR 6039 13681, 21323, 28965, 36607, 44249, 51891, 59533 anti-HIV_CDR 6040 13682, 21324, 28966, 36608, 44250, 51892, 59534 anti-HIV_CDR 6041 13683, 21325, 28967, 36609, 44251, 51893, 59535 anti-HIV_CDR 6042 13684, 21326, 28968, 36610, 44252, 51894, 59536 anti-HIV_CDR 6043 13685, 21327, 28969, 36611, 44253, 51895, 59537 anti-HIV_CDR 6044 13686, 21328, 28970, 36612, 44254, 51896, 59538 anti-HIV_CDR 6045 13687, 21329, 28971, 36613, 44255, 51897, 59539 anti-HIV_CDR 6046 13688, 21330, 28972, 36614, 44256, 51898, 59540 anti-HIV_CDR 6047 13689, 21331, 28973, 36615, 44257, 51899, 59541 anti-HIV_CDR 6048 13690, 21332, 28974, 36616, 44258, 51900, 59542 anti-HIV_CDR 6049 13691, 21333, 28975, 36617, 44259, 51901, 59543 anti-HIV_CDR 6050 13692, 21334, 28976, 36618, 44260, 51902, 59544 anti-HIV_CDR 6051 13693, 21335, 28977, 36619, 44261, 51903, 59545 anti-HIV_CDR 6052 13694, 21336, 28978, 36620, 44262, 51904, 59546 anti-HIV_CDR 6053 13695, 21337, 28979, 36621, 44263, 51905, 59547 anti-HIV_CDR 6054 13696, 21338, 28980, 36622, 44264, 51906, 59548 anti-HIV_CDR 6055 13697, 21339, 28981, 36623, 44265, 51907, 59549 anti-HIV_CDR 6056 13698, 21340, 28982, 36624, 44266, 51908, 59550 anti-HIV_CDR 6057 13699, 21341, 28983, 36625, 44267, 51909, 59551 anti-HIV_CDR 6058 13700, 21342, 28984, 36626, 44268, 51910, 59552 anti-HIV_CDR 6059 13701, 21343, 28985, 36627, 44269, 51911, 59553 anti-HIV_CDR 6060 13702, 21344, 28986, 36628, 44270, 51912, 59554 anti-HIV_CDR 6061 13703, 21345, 28987, 36629, 44271, 51913, 59555 anti-HIV_CDR 6062 13704, 21346, 28988, 36630, 44272, 51914, 59556 anti-HIV_CDR 6063 13705, 21347, 28989, 36631, 44273, 51915, 59557 anti-HIV_CDR 6064 13706, 21348, 28990, 36632, 44274, 51916, 59558 anti-HIV_CDR 6065 13707, 21349, 28991, 36633, 44275, 51917, 59559 anti-HIV_CDR 6066 13708, 21350, 28992, 36634, 44276, 51918, 59560 anti-HIV_CDR 6067 13709, 21351, 28993, 36635, 44277, 51919, 59561 anti-HIV_CDR 6068 13710, 21352, 28994, 36636, 44278, 51920, 59562 anti-HIV_CDR 6069 13711, 21353, 28995, 36637, 44279, 51921, 59563 anti-HIV_CDR 6070 13712, 21354, 28996, 36638, 44280, 51922, 59564 anti-HIV_CDR 6071 13713, 21355, 28997, 36639, 44281, 51923, 59565 anti-HIV_CDR 6072 13714, 21356, 28998, 36640, 44282, 51924, 59566 anti-HIV_CDR 6073 13715, 21357, 28999, 36641, 44283, 51925, 59567 anti-HIV_CDR 6074 13716, 21358, 29000, 36642, 44284, 51926, 59568 anti-HIV_CDR 6075 13717, 21359, 29001, 36643, 44285, 51927, 59569 anti-HIV_CDR 6076 13718, 21360, 29002, 36644, 44286, 51928, 59570 anti-HIV_CDR 6077 13719, 21361, 29003, 36645, 44287, 51929, 59571 anti-HIV_CDR 6078 13720, 21362, 29004, 36646, 44288, 51930, 59572 anti-HIV_CDR 6079 13721, 21363, 29005, 36647, 44289, 51931, 59573 anti-HIV_CDR 6080 13722, 21364, 29006, 36648, 44290, 51932, 59574 anti-HIV_CDR 6081 13723, 21365, 29007, 36649, 44291, 51933, 59575 anti-HIV_CDR 6082 13724, 21366, 29008, 36650, 44292, 51934, 59576 anti-HIV_CDR 6083 13725, 21367, 29009, 36651, 44293, 51935, 59577 anti-HIV_CDR 6084 13726, 21368, 29010, 36652, 44294, 51936, 59578 anti-HIV_CDR 6085 13727, 21369, 29011, 36653, 44295, 51937, 59579 anti-HIV_CDR 6086 13728, 21370, 29012, 36654, 44296, 51938, 59580 anti-HIV_CDR 6087 13729, 21371, 29013, 36655, 44297, 51939, 59581 anti-HIV_CDR 6088 13730, 21372, 29014, 36656, 44298, 51940, 59582 anti-HIV_CDR 6089 13731, 21373, 29015, 36657, 44299, 51941, 59583 anti-HIV_CDR 6090 13732, 21374, 29016, 36658, 44300, 51942, 59584 anti-HIV_CDR 6091 13733, 21375, 29017, 36659, 44301, 51943, 59585 anti-HIV_CDR 6092 13734, 21376, 29018, 36660, 44302, 51944, 59586 anti-HIV_CDR 6093 13735, 21377, 29019, 36661, 44303, 51945, 59587 anti-HIV_CDR 6094 13736, 21378, 29020, 36662, 44304, 51946, 59588 anti-HIV_CDR 6095 13737, 21379, 29021, 36663, 44305, 51947, 59589 anti-HIV_CDR 6096 13738, 21380, 29022, 36664, 44306, 51948, 59590 anti-HIV_CDR 6097 13739, 21381, 29023, 36665, 44307, 51949, 59591 anti-HIV_CDR 6098 13740, 21382, 29024, 36666, 44308, 51950, 59592 anti-HIV_CDR 6099 13741, 21383, 29025, 36667, 44309, 51951, 59593 anti-HIV_CDR 6100 13742, 21384, 29026, 36668, 44310, 51952, 59594 anti-HIV_CDR 6101 13743, 21385, 29027, 36669, 44311, 51953, 59595 anti-HIV_CDR 6102 13744, 21386, 29028, 36670, 44312, 51954, 59596 anti-HIV_CDR 6103 13745, 21387, 29029, 36671, 44313, 51955, 59597 anti-HIV_CDR 6104 13746, 21388, 29030, 36672, 44314, 51956, 59598 anti-HIV_CDR 6105 13747, 21389, 29031, 36673, 44315, 51957, 59599 anti-HIV_CDR 6106 13748, 21390, 29032, 36674, 44316, 51958, 59600 anti-HIV_CDR 6107 13749, 21391, 29033, 36675, 44317, 51959, 59601 anti-HIV_CDR 6108 13750, 21392, 29034, 36676, 44318, 51960, 59602 anti-HIV_CDR 6109 13751, 21393, 29035, 36677, 44319, 51961, 59603 anti-HIV_CDR 6110 13752, 21394, 29036, 36678, 44320, 51962, 59604 anti-HIV_CDR 6111 13753, 21395, 29037, 36679, 44321, 51963, 59605 anti-HIV_CDR 6112 13754, 21396, 29038, 36680, 44322, 51964, 59606 anti-HIV_CDR 6113 13755, 21397, 29039, 36681, 44323, 51965, 59607 anti-HIV_CDR 6114 13756, 21398, 29040, 36682, 44324, 51966, 59608 anti-HIV_CDR 6115 13757, 21399, 29041, 36683, 44325, 51967, 59609 anti-HIV_CDR 6116 13758, 21400, 29042, 36684, 44326, 51968, 59610 anti-HIV_CDR 6117 13759, 21401, 29043, 36685, 44327, 51969, 59611 anti-HIV_CDR 6118 13760, 21402, 29044, 36686, 44328, 51970, 59612 anti-HIV_CDR 6119 13761, 21403, 29045, 36687, 44329, 51971, 59613 anti-HIV_CDR 6120 13762, 21404, 29046, 36688, 44330, 51972, 59614 anti-HIV_CDR 6121 13763, 21405, 29047, 36689, 44331, 51973, 59615 anti-HIV_CDR 6122 13764, 21406, 29048, 36690, 44332, 51974, 59616 anti-HIV_CDR 6123 13765, 21407, 29049, 36691, 44333, 51975, 59617 anti-HIV_CDR 6124 13766, 21408, 29050, 36692, 44334, 51976, 59618 anti-HIV_CDR 6125 13767, 21409, 29051, 36693, 44335, 51977, 59619 anti-HIV_CDR 6126 13768, 21410, 29052, 36694, 44336, 51978, 59620 anti-HIV_CDR 6127 13769, 21411, 29053, 36695, 44337, 51979, 59621 anti-HIV_CDR 6128 13770, 21412, 29054, 36696, 44338, 51980, 59622 anti-HIV_CDR 6129 13771, 21413, 29055, 36697, 44339, 51981, 59623 anti-HIV_CDR 6130 13772, 21414, 29056, 36698, 44340, 51982, 59624 anti-HIV_CDR 6131 13773, 21415, 29057, 36699, 44341, 51983, 59625 anti-HIV_CDR 6132 13774, 21416, 29058, 36700, 44342, 51984, 59626 anti-HIV_CDR 6133 13775, 21417, 29059, 36701, 44343, 51985, 59627 anti-HIV_CDR 6134 13776, 21418, 29060, 36702, 44344, 51986, 59628 anti-HIV_CDR 6135 13777, 21419, 29061, 36703, 44345, 51987, 59629 anti-HIV_CDR 6136 13778, 21420, 29062, 36704, 44346, 51988, 59630 anti-HIV_CDR 6137 13779, 21421, 29063, 36705, 44347, 51989, 59631 anti-HIV_CDR 6138 13780, 21422, 29064, 36706, 44348, 51990, 59632 anti-HIV_CDR 6139 13781, 21423, 29065, 36707, 44349, 51991, 59633 anti-HIV_CDR 6140 13782, 21424, 29066, 36708, 44350, 51992, 59634 anti-HIV_CDR 6141 13783, 21425, 29067, 36709, 44351, 51993, 59635 anti-HIV_CDR 6142 13784, 21426, 29068, 36710, 44352, 51994, 59636 anti-HIV_CDR 6143 13785, 21427, 29069, 36711, 44353, 51995, 59637 anti-HIV_CDR 6144 13786, 21428, 29070, 36712, 44354, 51996, 59638 anti-HIV_CDR 6145 13787, 21429, 29071, 36713, 44355, 51997, 59639 anti-HIV_CDR 6146 13788, 21430, 29072, 36714, 44356, 51998, 59640 anti-HIV_CDR 6147 13789, 21431, 29073, 36715, 44357, 51999, 59641 anti-HIV_CDR 6148 13790, 21432, 29074, 36716, 44358, 52000, 59642 anti-HIV_CDR 6149 13791, 21433, 29075, 36717, 44359, 52001, 59643 anti-HIV_CDR 6150 13792, 21434, 29076, 36718, 44360, 52002, 59644 anti-HIV_CDR 6151 13793, 21435, 29077, 36719, 44361, 52003, 59645 anti-HIV_CDR 6152 13794, 21436, 29078, 36720, 44362, 52004, 59646 anti-HIV_CDR 6153 13795, 21437, 29079, 36721, 44363, 52005, 59647 anti-HIV_CDR 6154 13796, 21438, 29080, 36722, 44364, 52006, 59648 anti-HIV_CDR 6155 13797, 21439, 29081, 36723, 44365, 52007, 59649 anti-HIV_CDR 6156 13798, 21440, 29082, 36724, 44366, 52008, 59650 anti-HIV_CDR 6157 13799, 21441, 29083, 36725, 44367, 52009, 59651 anti-HIV_CDR 6158 13800, 21442, 29084, 36726, 44368, 52010, 59652 anti-HIV_CDR 6159 13801, 21443, 29085, 36727, 44369, 52011, 59653 anti-HIV_CDR 6160 13802, 21444, 29086, 36728, 44370, 52012, 59654 anti-HIV_CDR 6161 13803, 21445, 29087, 36729, 44371, 52013, 59655 anti-HIV_CDR 6162 13804, 21446, 29088, 36730, 44372, 52014, 59656 anti-HIV_CDR 6163 13805, 21447, 29089, 36731, 44373, 52015, 59657 anti-HIV_CDR 6164 13806, 21448, 29090, 36732, 44374, 52016, 59658 anti-HIV_CDR 6165 13807, 21449, 29091, 36733, 44375, 52017, 59659 anti-HIV_CDR 6166 13808, 21450, 29092, 36734, 44376, 52018, 59660 anti-HIV_CDR 6167 13809, 21451, 29093, 36735, 44377, 52019, 59661 anti-HIV_CDR 6168 13810, 21452, 29094, 36736, 44378, 52020, 59662 anti-HIV_CDR 6169 13811, 21453, 29095, 36737, 44379, 52021, 59663 anti-HIV_CDR 6170 13812, 21454, 29096, 36738, 44380, 52022, 59664 anti-HIV_CDR 6171 13813, 21455, 29097, 36739, 44381, 52023, 59665 anti-HIV_CDR 6172 13814, 21456, 29098, 36740, 44382, 52024, 59666 anti-HIV_CDR 6173 13815, 21457, 29099, 36741, 44383, 52025, 59667 anti-HIV_CDR 6174 13816, 21458, 29100, 36742, 44384, 52026, 59668 anti-HIV_CDR 6175 13817, 21459, 29101, 36743, 44385, 52027, 59669 anti-HIV_CDR 6176 13818, 21460, 29102, 36744, 44386, 52028, 59670 anti-HIV_CDR 6177 13819, 21461, 29103, 36745, 44387, 52029, 59671 anti-HIV_CDR 6178 13820, 21462, 29104, 36746, 44388, 52030, 59672 anti-HIV_CDR 6179 13821, 21463, 29105, 36747, 44389, 52031, 59673 anti-HIV_CDR 6180 13822, 21464, 29106, 36748, 44390, 52032, 59674 anti-HIV_CDR 6181 13823, 21465, 29107, 36749, 44391, 52033, 59675 anti-HIV_CDR 6182 13824, 21466, 29108, 36750, 44392, 52034, 59676 anti-HIV_CDR 6183 13825, 21467, 29109, 36751, 44393, 52035, 59677 anti-HIV_CDR 6184 13826, 21468, 29110, 36752, 44394, 52036, 59678 anti-HIV_CDR 6185 13827, 21469, 29111, 36753, 44395, 52037, 59679 anti-HIV_CDR 6186 13828, 21470, 29112, 36754, 44396, 52038, 59680 anti-HIV_CDR 6187 13829, 21471, 29113, 36755, 44397, 52039, 59681 anti-HIV_CDR 6188 13830, 21472, 29114, 36756, 44398, 52040, 59682 anti-HIV_CDR 6189 13831, 21473, 29115, 36757, 44399, 52041, 59683 anti-HIV_CDR 6190 13832, 21474, 29116, 36758, 44400, 52042, 59684 anti-HIV_CDR 6191 13833, 21475, 29117, 36759, 44401, 52043, 59685 anti-HIV_CDR 6192 13834, 21476, 29118, 36760, 44402, 52044, 59686 anti-HIV_CDR 6193 13835, 21477, 29119, 36761, 44403, 52045, 59687 anti-HIV_CDR 6194 13836, 21478, 29120, 36762, 44404, 52046, 59688 anti-HIV_CDR 6195 13837, 21479, 29121, 36763, 44405, 52047, 59689 anti-HIV_CDR 6196 13838, 21480, 29122, 36764, 44406, 52048, 59690 anti-HIV_CDR 6197 13839, 21481, 29123, 36765, 44407, 52049, 59691 anti-HIV_CDR 6198 13840, 21482, 29124, 36766, 44408, 52050, 59692 anti-HIV_CDR 6199 13841, 21483, 29125, 36767, 44409, 52051, 59693 anti-HIV_CDR 6200 13842, 21484, 29126, 36768, 44410, 52052, 59694 anti-HIV_CDR 6201 13843, 21485, 29127, 36769, 44411, 52053, 59695 anti-HIV_CDR 6202 13844, 21486, 29128, 36770, 44412, 52054, 59696 anti-HIV_CDR 6203 13845, 21487, 29129, 36771, 44413, 52055, 59697 anti-HIV_CDR 6204 13846, 21488, 29130, 36772, 44414, 52056, 59698 anti-HIV_CDR 6205 13847, 21489, 29131, 36773, 44415, 52057, 59699 anti-HIV_CDR 6206 13848, 21490, 29132, 36774, 44416, 52058, 59700 anti-HIV_CDR 6207 13849, 21491, 29133, 36775, 44417, 52059, 59701 anti-HIV_CDR 6208 13850, 21492, 29134, 36776, 44418, 52060, 59702 anti-HIV_CDR 6209 13851, 21493, 29135, 36777, 44419, 52061, 59703 anti-HIV_CDR 6210 13852, 21494, 29136, 36778, 44420, 52062, 59704 anti-HIV_CDR 6211 13853, 21495, 29137, 36779, 44421, 52063, 59705 anti-HIV_CDR 6212 13854, 21496, 29138, 36780, 44422, 52064, 59706 anti-HIV_CDR 6213 13855, 21497, 29139, 36781, 44423, 52065, 59707 anti-HIV_CDR 6214 13856, 21498, 29140, 36782, 44424, 52066, 59708 anti-HIV_CDR 6215 13857, 21499, 29141, 36783, 44425, 52067, 59709 anti-HIV_CDR 6216 13858, 21500, 29142, 36784, 44426, 52068, 59710 anti-HIV_CDR 6217 13859, 21501, 29143, 36785, 44427, 52069, 59711 anti-HIV_CDR 6218 13860, 21502, 29144, 36786, 44428, 52070, 59712 anti-HIV_CDR 6219 13861, 21503, 29145, 36787, 44429, 52071, 59713 anti-HIV_CDR 6220 13862, 21504, 29146, 36788, 44430, 52072, 59714 anti-HIV_CDR 6221 13863, 21505, 29147, 36789, 44431, 52073, 59715 anti-HIV_CDR 6222 13864, 21506, 29148, 36790, 44432, 52074, 59716 anti-HIV_CDR 6223 13865, 21507, 29149, 36791, 44433, 52075, 59717 anti-HIV_CDR 6224 13866, 21508, 29150, 36792, 44434, 52076, 59718 anti-HIV_CDR 6225 13867, 21509, 29151, 36793, 44435, 52077, 59719 anti-HIV_CDR 6226 13868, 21510, 29152, 36794, 44436, 52078, 59720 anti-HIV_CDR 6227 13869, 21511, 29153, 36795, 44437, 52079, 59721 anti-HIV_CDR 6228 13870, 21512, 29154, 36796, 44438, 52080, 59722 anti-HIV_CDR 6229 13871, 21513, 29155, 36797, 44439, 52081, 59723 anti-HIV_CDR 6230 13872, 21514, 29156, 36798, 44440, 52082, 59724 anti-HIV_CDR 6231 13873, 21515, 29157, 36799, 44441, 52083, 59725 anti-HIV_CDR 6232 13874, 21516, 29158, 36800, 44442, 52084, 59726 anti-HIV_CDR 6233 13875, 21517, 29159, 36801, 44443, 52085, 59727 anti-HIV_CDR 6234 13876, 21518, 29160, 36802, 44444, 52086, 59728 anti-HIV_CDR 6235 13877, 21519, 29161, 36803, 44445, 52087, 59729 anti-HIV_CDR 6236 13878, 21520, 29162, 36804, 44446, 52088, 59730 anti-HIV_CDR 6237 13879, 21521, 29163, 36805, 44447, 52089, 59731 anti-HIV_CDR 6238 13880, 21522, 29164, 36806, 44448, 52090, 59732 anti-HIV_CDR 6239 13881, 21523, 29165, 36807, 44449, 52091, 59733 anti-HIV_CDR 6240 13882, 21524, 29166, 36808, 44450, 52092, 59734 anti-HIV_CDR 6241 13883, 21525, 29167, 36809, 44451, 52093, 59735 anti-HIV_CDR 6242 13884, 21526, 29168, 36810, 44452, 52094, 59736 anti-HIV_CDR 6243 13885, 21527, 29169, 36811, 44453, 52095, 59737 anti-HIV_CDR 6244 13886, 21528, 29170, 36812, 44454, 52096, 59738 anti-HIV_CDR 6245 13887, 21529, 29171, 36813, 44455, 52097, 59739 anti-HIV_CDR 6246 13888, 21530, 29172, 36814, 44456, 52098, 59740 anti-HIV_CDR 6247 13889, 21531, 29173, 36815, 44457, 52099, 59741 anti-HIV_CDR 6248 13890, 21532, 29174, 36816, 44458, 52100, 59742 anti-HIV_CDR 6249 13891, 21533, 29175, 36817, 44459, 52101, 59743 anti-HIV_CDR 6250 13892, 21534, 29176, 36818, 44460, 52102, 59744 anti-HIV_CDR 6251 13893, 21535, 29177, 36819, 44461, 52103, 59745 anti-HIV_CDR 6252 13894, 21536, 29178, 36820, 44462, 52104, 59746 anti-HIV_CDR 6253 13895, 21537, 29179, 36821, 44463, 52105, 59747 anti-HIV_CDR 6254 13896, 21538, 29180, 36822, 44464, 52106, 59748 anti-HIV_CDR 6255 13897, 21539, 29181, 36823, 44465, 52107, 59749 anti-HIV_CDR 6256 13898, 21540, 29182, 36824, 44466, 52108, 59750 anti-HIV_CDR 6257 13899, 21541, 29183, 36825, 44467, 52109, 59751 anti-HIV_CDR 6258 13900, 21542, 29184, 36826, 44468, 52110, 59752 anti-HIV_CDR 6259 13901, 21543, 29185, 36827, 44469, 52111, 59753 anti-HIV_CDR 6260 13902, 21544, 29186, 36828, 44470, 52112, 59754 anti-HIV_CDR 6261 13903, 21545, 29187, 36829, 44471, 52113, 59755 anti-HIV_CDR 6262 13904, 21546, 29188, 36830, 44472, 52114, 59756 anti-HIV_CDR 6263 13905, 21547, 29189, 36831, 44473, 52115, 59757 anti-HIV_CDR 6264 13906, 21548, 29190, 36832, 44474, 52116, 59758 anti-HIV_CDR 6265 13907, 21549, 29191, 36833, 44475, 52117, 59759 anti-HIV_CDR 6266 13908, 21550, 29192, 36834, 44476, 52118, 59760 anti-HIV_CDR 6267 13909, 21551, 29193, 36835, 44477, 52119, 59761 anti-HIV_CDR 6268 13910, 21552, 29194, 36836, 44478, 52120, 59762 anti-HIV_CDR 6269 13911, 21553, 29195, 36837, 44479, 52121, 59763 anti-HIV_CDR 6270 13912, 21554, 29196, 36838, 44480, 52122, 59764 anti-HIV_CDR 6271 13913, 21555, 29197, 36839, 44481, 52123, 59765 anti-HIV_CDR 6272 13914, 21556, 29198, 36840, 44482, 52124, 59766 anti-HIV_CDR 6273 13915, 21557, 29199, 36841, 44483, 52125, 59767 anti-HIV_CDR 6274 13916, 21558, 29200, 36842, 44484, 52126, 59768 anti-HIV_CDR 6275 13917, 21559, 29201, 36843, 44485, 52127, 59769 anti-HIV_CDR 6276 13918, 21560, 29202, 36844, 44486, 52128, 59770 anti-HIV_CDR 6277 13919, 21561, 29203, 36845, 44487, 52129, 59771 anti-HIV_CDR 6278 13920, 21562, 29204, 36846, 44488, 52130, 59772 anti-HIV_CDR 6279 13921, 21563, 29205, 36847, 44489, 52131, 59773 anti-HIV_CDR 6280 13922, 21564, 29206, 36848, 44490, 52132, 59774 anti-HIV_CDR 6281 13923, 21565, 29207, 36849, 44491, 52133, 59775 anti-HIV_CDR 6282 13924, 21566, 29208, 36850, 44492, 52134, 59776 anti-HIV_CDR 6283 13925, 21567, 29209, 36851, 44493, 52135, 59777 anti-HIV_CDR 6284 13926, 21568, 29210, 36852, 44494, 52136, 59778 anti-HIV_CDR 6285 13927, 21569, 29211, 36853, 44495, 52137, 59779 anti-HIV_CDR 6286 13928, 21570, 29212, 36854, 44496, 52138, 59780 anti-HIV_CDR 6287 13929, 21571, 29213, 36855, 44497, 52139, 59781 anti-HIV_CDR 6288 13930, 21572, 29214, 36856, 44498, 52140, 59782 anti-HIV_CDR 6289 13931, 21573, 29215, 36857, 44499, 52141, 59783 anti-HIV_CDR 6290 13932, 21574, 29216, 36858, 44500, 52142, 59784 anti-HIV_CDR 6291 13933, 21575, 29217, 36859, 44501, 52143, 59785 anti-HIV_CDR 6292 13934, 21576, 29218, 36860, 44502, 52144, 59786 anti-HIV_CDR 6293 13935, 21577, 29219, 36861, 44503, 52145, 59787 anti-HIV_CDR 6294 13936, 21578, 29220, 36862, 44504, 52146, 59788 anti-HIV_CDR 6295 13937, 21579, 29221, 36863, 44505, 52147, 59789 anti-HIV_CDR 6296 13938, 21580, 29222, 36864, 44506, 52148, 59790 anti-HIV_CDR 6297 13939, 21581, 29223, 36865, 44507, 52149, 59791 anti-HIV_CDR 6298 13940, 21582, 29224, 36866, 44508, 52150, 59792 anti-HIV_CDR 6299 13941, 21583, 29225, 36867, 44509, 52151, 59793 anti-HIV_CDR 6300 13942, 21584, 29226, 36868, 44510, 52152, 59794 anti-HIV_CDR 6301 13943, 21585, 29227, 36869, 44511, 52153, 59795 anti-HIV_CDR 6302 13944, 21586, 29228, 36870, 44512, 52154, 59796 anti-HIV_CDR 6303 13945, 21587, 29229, 36871, 44513, 52155, 59797 anti-HIV_CDR 6304 13946, 21588, 29230, 36872, 44514, 52156, 59798 anti-HIV_CDR 6305 13947, 21589, 29231, 36873, 44515, 52157, 59799 anti-HIV_CDR 6306 13948, 21590, 29232, 36874, 44516, 52158, 59800 anti-HIV_CDR 6307 13949, 21591, 29233, 36875, 44517, 52159, 59801 anti-HIV_CDR 6308 13950, 21592, 29234, 36876, 44518, 52160, 59802 anti-HIV_CDR 6309 13951, 21593, 29235, 36877, 44519, 52161, 59803 anti-HIV_CDR 6310 13952, 21594, 29236, 36878, 44520, 52162, 59804 anti-HIV_CDR 6311 13953, 21595, 29237, 36879, 44521, 52163, 59805 anti-HIV_CDR 6312 13954, 21596, 29238, 36880, 44522, 52164, 59806 anti-HIV_CDR 6313 13955, 21597, 29239, 36881, 44523, 52165, 59807 anti-HIV_CDR 6314 13956, 21598, 29240, 36882, 44524, 52166, 59808 anti-HIV_CDR 6315 13957, 21599, 29241, 36883, 44525, 52167, 59809 anti-HIV_CDR 6316 13958, 21600, 29242, 36884, 44526, 52168, 59810 anti-HIV_CDR 6317 13959, 21601, 29243, 36885, 44527, 52169, 59811 anti-HIV_CDR 6318 13960, 21602, 29244, 36886, 44528, 52170, 59812 anti-HIV_CDR 6319 13961, 21603, 29245, 36887, 44529, 52171, 59813 anti-HIV_CDR 6320 13962, 21604, 29246, 36888, 44530, 52172, 59814 anti-HIV_CDR 6321 13963, 21605, 29247, 36889, 44531, 52173, 59815 anti-HIV_CDR 6322 13964, 21606, 29248, 36890, 44532, 52174, 59816 anti-HIV_CDR 6323 13965, 21607, 29249, 36891, 44533, 52175, 59817 anti-HIV_CDR 6324 13966, 21608, 29250, 36892, 44534, 52176, 59818 anti-HIV_CDR 6325 13967, 21609, 29251, 36893, 44535, 52177, 59819 anti-HIV_CDR 6326 13968, 21610, 29252, 36894, 44536, 52178, 59820 anti-HIV_CDR 6327 13969, 21611, 29253, 36895, 44537, 52179, 59821 anti-HIV_CDR 6328 13970, 21612, 29254, 36896, 44538, 52180, 59822 anti-HIV_CDR 6329 13971, 21613, 29255, 36897, 44539, 52181, 59823 anti-HIV_CDR 6330 13972, 21614, 29256, 36898, 44540, 52182, 59824 anti-HIV_CDR 6331 13973, 21615, 29257, 36899, 44541, 52183, 59825 anti-HIV_CDR 6332 13974, 21616, 29258, 36900, 44542, 52184, 59826 anti-HIV_CDR 6333 13975, 21617, 29259, 36901, 44543, 52185, 59827 anti-HIV_CDR 6334 13976, 21618, 29260, 36902, 44544, 52186, 59828 anti-HIV_CDR 6335 13977, 21619, 29261, 36903, 44545, 52187, 59829 anti-HIV_CDR 6336 13978, 21620, 29262, 36904, 44546, 52188, 59830 anti-HIV_CDR 6337 13979, 21621, 29263, 36905, 44547, 52189, 59831 anti-HIV_CDR 6338 13980, 21622, 29264, 36906, 44548, 52190, 59832 anti-HIV_CDR 6339 13981, 21623, 29265, 36907, 44549, 52191, 59833 anti-HIV_CDR 6340 13982, 21624, 29266, 36908, 44550, 52192, 59834 anti-HIV_CDR 6341 13983, 21625, 29267, 36909, 44551, 52193, 59835 anti-HIV_CDR 6342 13984, 21626, 29268, 36910, 44552, 52194, 59836 anti-HIV_CDR 6343 13985, 21627, 29269, 36911, 44553, 52195, 59837 anti-HIV_CDR 6344 13986, 21628, 29270, 36912, 44554, 52196, 59838 anti-HIV_CDR 6345 13987, 21629, 29271, 36913, 44555, 52197, 59839 anti-HIV_CDR 6346 13988, 21630, 29272, 36914, 44556, 52198, 59840 anti-HIV_CDR 6347 13989, 21631, 29273, 36915, 44557, 52199, 59841 anti-HIV_CDR 6348 13990, 21632, 29274, 36916, 44558, 52200, 59842 anti-HIV_CDR 6349 13991, 21633, 29275, 36917, 44559, 52201, 59843 anti-HIV_CDR 6350 13992, 21634, 29276, 36918, 44560, 52202, 59844 anti-HIV_CDR 6351 13993, 21635, 29277, 36919, 44561, 52203, 59845 anti-HIV_CDR 6352 13994, 21636, 29278, 36920, 44562, 52204, 59846 anti-HIV_CDR 6353 13995, 21637, 29279, 36921, 44563, 52205, 59847 anti-HIV_CDR 6354 13996, 21638, 29280, 36922, 44564, 52206, 59848 anti-HIV_CDR 6355 13997, 21639, 29281, 36923, 44565, 52207, 59849 anti-HIV_CDR 6356 13998, 21640, 29282, 36924, 44566, 52208, 59850 anti-HIV_CDR 6357 13999, 21641, 29283, 36925, 44567, 52209, 59851 anti-HIV_CDR 6358 14000, 21642, 29284, 36926, 44568, 52210, 59852 anti-HIV_CDR 6359 14001, 21643, 29285, 36927, 44569, 52211, 59853 anti-HIV_CDR 6360 14002, 21644, 29286, 36928, 44570, 52212, 59854 anti-HIV_CDR 6361 14003, 21645, 29287, 36929, 44571, 52213, 59855 anti-HIV_CDR 6362 14004, 21646, 29288, 36930, 44572, 52214, 59856 anti-HIV_CDR 6363 14005, 21647, 29289, 36931, 44573, 52215, 59857 anti-HIV_CDR 6364 14006, 21648, 29290, 36932, 44574, 52216, 59858 anti-HIV_CDR 6365 14007, 21649, 29291, 36933, 44575, 52217, 59859 anti-HIV_CDR 6366 14008, 21650, 29292, 36934, 44576, 52218, 59860 anti-HIV_CDR 6367 14009, 21651, 29293, 36935, 44577, 52219, 59861 anti-HIV_CDR 6368 14010, 21652, 29294, 36936, 44578, 52220, 59862 anti-HIV_CDR 6369 14011, 21653, 29295, 36937, 44579, 52221, 59863 anti-HIV_CDR 6370 14012, 21654, 29296, 36938, 44580, 52222, 59864 anti-HIV_CDR 6371 14013, 21655, 29297, 36939, 44581, 52223, 59865 anti-HIV_CDR 6372 14014, 21656, 29298, 36940, 44582, 52224, 59866 anti-HIV_CDR 6373 14015, 21657, 29299, 36941, 44583, 52225, 59867 anti-HIV_CDR 6374 14016, 21658, 29300, 36942, 44584, 52226, 59868 anti-HIV_CDR 6375 14017, 21659, 29301, 36943, 44585, 52227, 59869 anti-HIV_CDR 6376 14018, 21660, 29302, 36944, 44586, 52228, 59870 anti-HIV_CDR 6377 14019, 21661, 29303, 36945, 44587, 52229, 59871 anti-HIV_CDR 6378 14020, 21662, 29304, 36946, 44588, 52230, 59872 anti-HIV_CDR 6379 14021, 21663, 29305, 36947, 44589, 52231, 59873 anti-HIV_CDR 6380 14022, 21664, 29306, 36948, 44590, 52232, 59874 anti-HIV_CDR 6381 14023, 21665, 29307, 36949, 44591, 52233, 59875 anti-HIV_CDR 6382 14024, 21666, 29308, 36950, 44592, 52234, 59876 anti-HIV_CDR 6383 14025, 21667, 29309, 36951, 44593, 52235, 59877 anti-HIV_CDR 6384 14026, 21668, 29310, 36952, 44594, 52236, 59878 anti-HIV_CDR 6385 14027, 21669, 29311, 36953, 44595, 52237, 59879 anti-HIV_CDR 6386 14028, 21670, 29312, 36954, 44596, 52238, 59880 anti-HIV_CDR 6387 14029, 21671, 29313, 36955, 44597, 52239, 59881 anti-HIV_CDR 6388 14030, 21672, 29314, 36956, 44598, 52240, 59882 anti-HIV_CDR 6389 14031, 21673, 29315, 36957, 44599, 52241, 59883 anti-HIV_CDR 6390 14032, 21674, 29316, 36958, 44600, 52242, 59884 anti-HIV_CDR 6391 14033, 21675, 29317, 36959, 44601, 52243, 59885 anti-HIV_CDR 6392 14034, 21676, 29318, 36960, 44602, 52244, 59886 anti-HIV_CDR 6393 14035, 21677, 29319, 36961, 44603, 52245, 59887 anti-HIV_CDR 6394 14036, 21678, 29320, 36962, 44604, 52246, 59888 anti-HIV_CDR 6395 14037, 21679, 29321, 36963, 44605, 52247, 59889 anti-HIV_CDR 6396 14038, 21680, 29322, 36964, 44606, 52248, 59890 anti-HIV_CDR 6397 14039, 21681, 29323, 36965, 44607, 52249, 59891 anti-HIV_CDR 6398 14040, 21682, 29324, 36966, 44608, 52250, 59892 anti-HIV_CDR 6399 14041, 21683, 29325, 36967, 44609, 52251, 59893 anti-HIV_CDR 6400 14042, 21684, 29326, 36968, 44610, 52252, 59894 anti-HIV_CDR 6401 14043, 21685, 29327, 36969, 44611, 52253, 59895 anti-HIV_CDR 6402 14044, 21686, 29328, 36970, 44612, 52254, 59896 anti-HIV_CDR 6403 14045, 21687, 29329, 36971, 44613, 52255, 59897 anti-HIV_CDR 6404 14046, 21688, 29330, 36972, 44614, 52256, 59898 anti-HIV_CDR 6405 14047, 21689, 29331, 36973, 44615, 52257, 59899 anti-HIV_CDR 6406 14048, 21690, 29332, 36974, 44616, 52258, 59900 anti-HIV_CDR 6407 14049, 21691, 29333, 36975, 44617, 52259, 59901 anti-HIV_CDR 6408 14050, 21692, 29334, 36976, 44618, 52260, 59902 anti-HIV_CDR 6409 14051, 21693, 29335, 36977, 44619, 52261, 59903 anti-HIV_CDR 6410 14052, 21694, 29336, 36978, 44620, 52262, 59904 anti-HIV_CDR 6411 14053, 21695, 29337, 36979, 44621, 52263, 59905 anti-HIV_CDR 6412 14054, 21696, 29338, 36980, 44622, 52264, 59906 anti-HIV_CDR 6413 14055, 21697, 29339, 36981, 44623, 52265, 59907 anti-HIV_CDR 6414 14056, 21698, 29340, 36982, 44624, 52266, 59908 anti-HIV_CDR 6415 14057, 21699, 29341, 36983, 44625, 52267, 59909 anti-HIV_CDR 6416 14058, 21700, 29342, 36984, 44626, 52268, 59910 anti-HIV_CDR 6417 14059, 21701, 29343, 36985, 44627, 52269, 59911 anti-HIV_CDR 6418 14060, 21702, 29344, 36986, 44628, 52270, 59912 anti-HIV_CDR 6419 14061, 21703, 29345, 36987, 44629, 52271, 59913 anti-HIV_CDR 6420 14062, 21704, 29346, 36988, 44630, 52272, 59914 anti-HIV_CDR 6421 14063, 21705, 29347, 36989, 44631, 52273, 59915 anti-HIV_CDR 6422 14064, 21706, 29348, 36990, 44632, 52274, 59916 anti-HIV_CDR 6423 14065, 21707, 29349, 36991, 44633, 52275, 59917 anti-HIV_CDR 6424 14066, 21708, 29350, 36992, 44634, 52276, 59918 anti-HIV_CDR 6425 14067, 21709, 29351, 36993, 44635, 52277, 59919 anti-HIV_CDR 6426 14068, 21710, 29352, 36994, 44636, 52278, 59920 anti-HIV_CDR 6427 14069, 21711, 29353, 36995, 44637, 52279, 59921 anti-HIV_CDR 6428 14070, 21712, 29354, 36996, 44638, 52280, 59922 anti-HIV_CDR 6429 14071, 21713, 29355, 36997, 44639, 52281, 59923 anti-HIV_CDR 6430 14072, 21714, 29356, 36998, 44640, 52282, 59924 anti-HIV_CDR 6431 14073, 21715, 29357, 36999, 44641, 52283, 59925 anti-HIV_CDR 6432 14074, 21716, 29358, 37000, 44642, 52284, 59926 anti-HIV_CDR 6433 14075, 21717, 29359, 37001, 44643, 52285, 59927 anti-HIV_CDR 6434 14076, 21718, 29360, 37002, 44644, 52286, 59928 anti-HIV_CDR 6435 14077, 21719, 29361, 37003, 44645, 52287, 59929 anti-HIV_CDR 6436 14078, 21720, 29362, 37004, 44646, 52288, 59930 anti-HIV_CDR 6437 14079, 21721, 29363, 37005, 44647, 52289, 59931 anti-HIV_CDR 6438 14080, 21722, 29364, 37006, 44648, 52290, 59932 anti-HIV_CDR 6439 14081, 21723, 29365, 37007, 44649, 52291, 59933 anti-HIV_CDR 6440 14082, 21724, 29366, 37008, 44650, 52292, 59934 anti-HIV_CDR 6441 14083, 21725, 29367, 37009, 44651, 52293, 59935 anti-HIV_CDR 6442 14084, 21726, 29368, 37010, 44652, 52294, 59936 anti-HIV_CDR 6443 14085, 21727, 29369, 37011, 44653, 52295, 59937 anti-HIV_CDR 6444 14086, 21728, 29370, 37012, 44654, 52296, 59938 anti-HIV_CDR 6445 14087, 21729, 29371, 37013, 44655, 52297, 59939 anti-HIV_CDR 6446 14088, 21730, 29372, 37014, 44656, 52298, 59940 anti-HIV_CDR 6447 14089, 21731, 29373, 37015, 44657, 52299, 59941 anti-HIV_CDR 6448 14090, 21732, 29374, 37016, 44658, 52300, 59942 anti-HIV_CDR 6449 14091, 21733, 29375, 37017, 44659, 52301, 59943 anti-HIV_CDR 6450 14092, 21734, 29376, 37018, 44660, 52302, 59944 anti-HIV_CDR 6451 14093, 21735, 29377, 37019, 44661, 52303, 59945 anti-HIV_CDR 6452 14094, 21736, 29378, 37020, 44662, 52304, 59946 anti-HIV_CDR 6453 14095, 21737, 29379, 37021, 44663, 52305, 59947 anti-HIV_CDR 6454 14096, 21738, 29380, 37022, 44664, 52306, 59948 anti-HIV_CDR 6455 14097, 21739, 29381, 37023, 44665, 52307, 59949 anti-HIV_CDR 6456 14098, 21740, 29382, 37024, 44666, 52308, 59950 anti-HIV_CDR 6457 14099, 21741, 29383, 37025, 44667, 52309, 59951 anti-HIV_CDR 6458 14100, 21742, 29384, 37026, 44668, 52310, 59952 anti-HIV_CDR 6459 14101, 21743, 29385, 37027, 44669, 52311, 59953 anti-HIV_CDR 6460 14102, 21744, 29386, 37028, 44670, 52312, 59954 anti-HIV_CDR 6461 14103, 21745, 29387, 37029, 44671, 52313, 59955 anti-HIV_CDR 6462 14104, 21746, 29388, 37030, 44672, 52314, 59956 anti-HIV_CDR 6463 14105, 21747, 29389, 37031, 44673, 52315, 59957 anti-HIV_CDR 6464 14106, 21748, 29390, 37032, 44674, 52316, 59958 anti-HIV_CDR 6465 14107, 21749, 29391, 37033, 44675, 52317, 59959 anti-HIV_CDR 6466 14108, 21750, 29392, 37034, 44676, 52318, 59960 anti-HIV_CDR 6467 14109, 21751, 29393, 37035, 44677, 52319, 59961 anti-HIV_CDR 6468 14110, 21752, 29394, 37036, 44678, 52320, 59962 anti-HIV_CDR 6469 14111, 21753, 29395, 37037, 44679, 52321, 59963 anti-HIV_CDR 6470 14112, 21754, 29396, 37038, 44680, 52322, 59964 anti-HIV_CDR 6471 14113, 21755, 29397, 37039, 44681, 52323, 59965 anti-HIV_CDR 6472 14114, 21756, 29398, 37040, 44682, 52324, 59966 anti-HIV_CDR 6473 14115, 21757, 29399, 37041, 44683, 52325, 59967 anti-HIV_CDR 6474 14116, 21758, 29400, 37042, 44684, 52326, 59968 anti-HIV_CDR 6475 14117, 21759, 29401, 37043, 44685, 52327, 59969 anti-HIV_CDR 6476 14118, 21760, 29402, 37044, 44686, 52328, 59970 anti-HIV_CDR 6477 14119, 21761, 29403, 37045, 44687, 52329, 59971 anti-influenza_CDR 6478 14120, 21762, 29404, 37046, 44688, 52330, 59972 anti-influenza_CDR 6479 14121, 21763, 29405, 37047, 44689, 52331, 59973 anti-influenza_CDR 6480 14122, 21764, 29406, 37048, 44690, 52332, 59974 anti-influenza_CDR 6481 14123, 21765, 29407, 37049, 44691, 52333, 59975 anti-influenza_CDR 6482 14124, 21766, 29408, 37050, 44692, 52334, 59976 anti-influenza_CDR 6483 14125, 21767, 29409, 37051, 44693, 52335, 59977 anti-influenza_CDR 6484 14126, 21768, 29410, 37052, 44694, 52336, 59978 anti-influenza_CDR 6485 14127, 21769, 29411, 37053, 44695, 52337, 59979 anti-influenza_CDR 6486 14128, 21770, 29412, 37054, 44696, 52338, 59980 anti-influenza_CDR 6487 14129, 21771, 29413, 37055, 44697, 52339, 59981 anti-influenza_CDR 6488 14130, 21772, 29414, 37056, 44698, 52340, 59982 anti-influenza_CDR 6489 14131, 21773, 29415, 37057, 44699, 52341, 59983 anti-influenza_CDR 6490 14132, 21774, 29416, 37058, 44700, 52342, 59984 anti-influenza_CDR 6491 14133, 21775, 29417, 37059, 44701, 52343, 59985 anti-influenza_CDR 6492 14134, 21776, 29418, 37060, 44702, 52344, 59986 anti-influenza_CDR 6493 14135, 21777, 29419, 37061, 44703, 52345, 59987 anti-influenza_CDR 6494 14136, 21778, 29420, 37062, 44704, 52346, 59988 anti-influenza_CDR 6495 14137, 21779, 29421, 37063, 44705, 52347, 59989 anti-influenza_CDR 6496 14138, 21780, 29422, 37064, 44706, 52348, 59990 anti-influenza_CDR 6497 14139, 21781, 29423, 37065, 44707, 52349, 59991 anti-influenza_CDR 6498 14140, 21782, 29424, 37066, 44708, 52350, 59992 anti-influenza_CDR 6499 14141, 21783, 29425, 37067, 44709, 52351, 59993 anti-influenza_CDR 6500 14142, 21784, 29426, 37068, 44710, 52352, 59994 anti-influenza_CDR 6501 14143, 21785, 29427, 37069, 44711, 52353, 59995 anti-influenza_CDR 6502 14144, 21786, 29428, 37070, 44712, 52354, 59996 anti-influenza_CDR 6503 14145, 21787, 29429, 37071, 44713, 52355, 59997 anti-influenza_CDR 6504 14146, 21788, 29430, 37072, 44714, 52356, 59998 anti-influenza_CDR 6505 14147, 21789, 29431, 37073, 44715, 52357, 59999 anti-influenza_CDR 6506 14148, 21790, 29432, 37074, 44716, 52358, 60000 anti-influenza_CDR 6507 14149, 21791, 29433, 37075, 44717, 52359, 60001 anti-influenza_CDR 6508 14150, 21792, 29434, 37076, 44718, 52360, 60002 anti-influenza_CDR 6509 14151, 21793, 29435, 37077, 44719, 52361, 60003 anti-influenza_CDR 6510 14152, 21794, 29436, 37078, 44720, 52362, 60004 anti-influenza_CDR 6511 14153, 21795, 29437, 37079, 44721, 52363, 60005 anti-influenza_CDR 6512 14154, 21796, 29438, 37080, 44722, 52364, 60006 anti-influenza_CDR 6513 14155, 21797, 29439, 37081, 44723, 52365, 60007 anti-influenza_CDR 6514 14156, 21798, 29440, 37082, 44724, 52366, 60008 anti-influenza_CDR 6515 14157, 21799, 29441, 37083, 44725, 52367, 60009 anti-influenza_CDR 6516 14158, 21800, 29442, 37084, 44726, 52368, 60010 anti-influenza_CDR 6517 14159, 21801, 29443, 37085, 44727, 52369, 60011 anti-influenza_CDR 6518 14160, 21802, 29444, 37086, 44728, 52370, 60012 anti-influenza_CDR 6519 14161, 21803, 29445, 37087, 44729, 52371, 60013 anti-influenza_CDR 6520 14162, 21804, 29446, 37088, 44730, 52372, 60014 anti-influenza_CDR 6521 14163, 21805, 29447, 37089, 44731, 52373, 60015 anti-influenza_CDR 6522 14164, 21806, 29448, 37090, 44732, 52374, 60016 anti-influenza_CDR 6523 14165, 21807, 29449, 37091, 44733, 52375, 60017 anti-influenza_CDR 6524 14166, 21808, 29450, 37092, 44734, 52376, 60018 anti-influenza_CDR 6525 14167, 21809, 29451, 37093, 44735, 52377, 60019 anti-influenza_CDR 6526 14168, 21810, 29452, 37094, 44736, 52378, 60020 anti-influenza_CDR 6527 14169, 21811, 29453, 37095, 44737, 52379, 60021 anti-influenza_CDR 6528 14170, 21812, 29454, 37096, 44738, 52380, 60022 anti-influenza_CDR 6529 14171, 21813, 29455, 37097, 44739, 52381, 60023 anti-influenza_CDR 6530 14172, 21814, 29456, 37098, 44740, 52382, 60024 anti-influenza_CDR 6531 14173, 21815, 29457, 37099, 44741, 52383, 60025 anti-influenza_CDR 6532 14174, 21816, 29458, 37100, 44742, 52384, 60026 anti-influenza_CDR 6533 14175, 21817, 29459, 37101, 44743, 52385, 60027 anti-influenza_CDR 6534 14176, 21818, 29460, 37102, 44744, 52386, 60028 anti-influenza_CDR 6535 14177, 21819, 29461, 37103, 44745, 52387, 60029 anti-influenza_CDR 6536 14178, 21820, 29462, 37104, 44746, 52388, 60030 anti-influenza_CDR 6537 14179, 21821, 29463, 37105, 44747, 52389, 60031 anti-influenza_CDR 6538 14180, 21822, 29464, 37106, 44748, 52390, 60032 anti-influenza_CDR 6539 14181, 21823, 29465, 37107, 44749, 52391, 60033 anti-influenza_CDR 6540 14182, 21824, 29466, 37108, 44750, 52392, 60034 anti-influenza_CDR 6541 14183, 21825, 29467, 37109, 44751, 52393, 60035 anti-influenza_CDR 6542 14184, 21826, 29468, 37110, 44752, 52394, 60036 anti-influenza_CDR 6543 14185, 21827, 29469, 37111, 44753, 52395, 60037 anti-influenza_CDR 6544 14186, 21828, 29470, 37112, 44754, 52396, 60038 anti-influenza_CDR 6545 14187, 21829, 29471, 37113, 44755, 52397, 60039 anti-influenza_CDR 6546 14188, 21830, 29472, 37114, 44756, 52398, 60040 anti-influenza_CDR 6547 14189, 21831, 29473, 37115, 44757, 52399, 60041 anti-influenza_CDR 6548 14190, 21832, 29474, 37116, 44758, 52400, 60042 anti-influenza_CDR 6549 14191, 21833, 29475, 37117, 44759, 52401, 60043 anti-influenza_CDR 6550 14192, 21834, 29476, 37118, 44760, 52402, 60044 anti-influenza_CDR 6551 14193, 21835, 29477, 37119, 44761, 52403, 60045 anti-influenza_CDR 6552 14194, 21836, 29478, 37120, 44762, 52404, 60046 anti-influenza_CDR 6553 14195, 21837, 29479, 37121, 44763, 52405, 60047 anti-influenza_CDR 6554 14196, 21838, 29480, 37122, 44764, 52406, 60048 anti-influenza_CDR 6555 14197, 21839, 29481, 37123, 44765, 52407, 60049 anti-influenza_CDR 6556 14198, 21840, 29482, 37124, 44766, 52408, 60050 anti-influenza_CDR 6557 14199, 21841, 29483, 37125, 44767, 52409, 60051 anti-influenza_CDR 6558 14200, 21842, 29484, 37126, 44768, 52410, 60052 anti-influenza_CDR 6559 14201, 21843, 29485, 37127, 44769, 52411, 60053 anti-influenza_CDR 6560 14202, 21844, 29486, 37128, 44770, 52412, 60054 anti-influenza_CDR 6561 14203, 21845, 29487, 37129, 44771, 52413, 60055 anti-influenza_CDR 6562 14204, 21846, 29488, 37130, 44772, 52414, 60056 anti-influenza_CDR 6563 14205, 21847, 29489, 37131, 44773, 52415, 60057 anti-influenza_CDR 6564 14206, 21848, 29490, 37132, 44774, 52416, 60058 anti-influenza_CDR 6565 14207, 21849, 29491, 37133, 44775, 52417, 60059 anti-influenza_CDR 6566 14208, 21850, 29492, 37134, 44776, 52418, 60060 anti-influenza_CDR 6567 14209, 21851, 29493, 37135, 44777, 52419, 60061 anti-influenza_CDR 6568 14210, 21852, 29494, 37136, 44778, 52420, 60062 anti-influenza_CDR 6569 14211, 21853, 29495, 37137, 44779, 52421, 60063 anti-influenza_CDR 6570 14212, 21854, 29496, 37138, 44780, 52422, 60064 anti-influenza_CDR 6571 14213, 21855, 29497, 37139, 44781, 52423, 60065 anti-influenza_CDR 6572 14214, 21856, 29498, 37140, 44782, 52424, 60066 anti-influenza_CDR 6573 14215, 21857, 29499, 37141, 44783, 52425, 60067 anti-influenza_CDR 6574 14216, 21858, 29500, 37142, 44784, 52426, 60068 anti-influenza_CDR 6575 14217, 21859, 29501, 37143, 44785, 52427, 60069 anti-influenza_CDR 6576 14218, 21860, 29502, 37144, 44786, 52428, 60070 anti-influenza_CDR 6577 14219, 21861, 29503, 37145, 44787, 52429, 60071 anti-influenza_CDR 6578 14220, 21862, 29504, 37146, 44788, 52430, 60072 anti-influenza_CDR 6579 14221, 21863, 29505, 37147, 44789, 52431, 60073 anti-influenza_CDR 6580 14222, 21864, 29506, 37148, 44790, 52432, 60074 anti-influenza_CDR 6581 14223, 21865, 29507, 37149, 44791, 52433, 60075 anti-influenza_CDR 6582 14224, 21866, 29508, 37150, 44792, 52434, 60076 anti-influenza_CDR 6583 14225, 21867, 29509, 37151, 44793, 52435, 60077 anti-influenza_CDR 6584 14226, 21868, 29510, 37152, 44794, 52436, 60078 anti-influenza_CDR 6585 14227, 21869, 29511, 37153, 44795, 52437, 60079 anti-influenza_CDR 6586 14228, 21870, 29512, 37154, 44796, 52438, 60080 anti-influenza_CDR 6587 14229, 21871, 29513, 37155, 44797, 52439, 60081 anti-influenza_CDR 6588 14230, 21872, 29514, 37156, 44798, 52440, 60082 anti-influenza_CDR 6589 14231, 21873, 29515, 37157, 44799, 52441, 60083 anti-influenza_CDR 6590 14232, 21874, 29516, 37158, 44800, 52442, 60084 anti-influenza_CDR 6591 14233, 21875, 29517, 37159, 44801, 52443, 60085 anti-influenza_CDR 6592 14234, 21876, 29518, 37160, 44802, 52444, 60086 anti-influenza_CDR 6593 14235, 21877, 29519, 37161, 44803, 52445, 60087 anti-influenza_CDR 6594 14236, 21878, 29520, 37162, 44804, 52446, 60088 anti-influenza_CDR 6595 14237, 21879, 29521, 37163, 44805, 52447, 60089 anti-influenza_CDR 6596 14238, 21880, 29522, 37164, 44806, 52448, 60090 anti-influenza_CDR 6597 14239, 21881, 29523, 37165, 44807, 52449, 60091 anti-influenza_CDR 6598 14240, 21882, 29524, 37166, 44808, 52450, 60092 anti-influenza_CDR 6599 14241, 21883, 29525, 37167, 44809, 52451, 60093 anti-influenza_CDR 6600 14242, 21884, 29526, 37168, 44810, 52452, 60094 anti-influenza_CDR 6601 14243, 21885, 29527, 37169, 44811, 52453, 60095 anti-influenza_CDR 6602 14244, 21886, 29528, 37170, 44812, 52454, 60096 anti-influenza_CDR 6603 14245, 21887, 29529, 37171, 44813, 52455, 60097 anti-influenza_CDR 6604 14246, 21888, 29530, 37172, 44814, 52456, 60098 anti-influenza_CDR 6605 14247, 21889, 29531, 37173, 44815, 52457, 60099 anti-influenza_CDR 6606 14248, 21890, 29532, 37174, 44816, 52458, 60100 anti-influenza_CDR 6607 14249, 21891, 29533, 37175, 44817, 52459, 60101 anti-influenza_CDR 6608 14250, 21892, 29534, 37176, 44818, 52460, 60102 anti-influenza_CDR 6609 14251, 21893, 29535, 37177, 44819, 52461, 60103 anti-influenza_CDR 6610 14252, 21894, 29536, 37178, 44820, 52462, 60104 anti-influenza_CDR 6611 14253, 21895, 29537, 37179, 44821, 52463, 60105 anti-influenza_CDR 6612 14254, 21896, 29538, 37180, 44822, 52464, 60106 anti-influenza_CDR 6613 14255, 21897, 29539, 37181, 44823, 52465, 60107 anti-influenza_CDR 6614 14256, 21898, 29540, 37182, 44824, 52466, 60108 anti-influenza_CDR 6615 14257, 21899, 29541, 37183, 44825, 52467, 60109 anti-influenza_CDR 6616 14258, 21900, 29542, 37184, 44826, 52468, 60110 anti-influenza_CDR 6617 14259, 21901, 29543, 37185, 44827, 52469, 60111 anti-influenza_CDR 6618 14260, 21902, 29544, 37186, 44828, 52470, 60112 anti-influenza_CDR 6619 14261, 21903, 29545, 37187, 44829, 52471, 60113 anti-influenza_CDR 6620 14262, 21904, 29546, 37188, 44830, 52472, 60114 anti-influenza_CDR 6621 14263, 21905, 29547, 37189, 44831, 52473, 60115 anti-influenza_CDR 6622 14264, 21906, 29548, 37190, 44832, 52474, 60116 anti-influenza_CDR 6623 14265, 21907, 29549, 37191, 44833, 52475, 60117 anti-influenza_CDR 6624 14266, 21908, 29550, 37192, 44834, 52476, 60118 anti-influenza_CDR 6625 14267, 21909, 29551, 37193, 44835, 52477, 60119 anti-influenza_CDR 6626 14268, 21910, 29552, 37194, 44836, 52478, 60120 anti-influenza_CDR 6627 14269, 21911, 29553, 37195, 44837, 52479, 60121 anti-influenza_CDR 6628 14270, 21912, 29554, 37196, 44838, 52480, 60122 anti-influenza_CDR 6629 14271, 21913, 29555, 37197, 44839, 52481, 60123 anti-influenza_CDR 6630 14272, 21914, 29556, 37198, 44840, 52482, 60124 anti-influenza_CDR 6631 14273, 21915, 29557, 37199, 44841, 52483, 60125 anti-influenza_CDR 6632 14274, 21916, 29558, 37200, 44842, 52484, 60126 anti-influenza_CDR 6633 14275, 21917, 29559, 37201, 44843, 52485, 60127 anti-influenza_CDR 6634 14276, 21918, 29560, 37202, 44844, 52486, 60128 anti-influenza_CDR 6635 14277, 21919, 29561, 37203, 44845, 52487, 60129 anti-influenza_CDR 6636 14278, 21920, 29562, 37204, 44846, 52488, 60130 anti-influenza_CDR 6637 14279, 21921, 29563, 37205, 44847, 52489, 60131 anti-influenza_CDR 6638 14280, 21922, 29564, 37206, 44848, 52490, 60132 anti-influenza_CDR 6639 14281, 21923, 29565, 37207, 44849, 52491, 60133 anti-influenza_CDR 6640 14282, 21924, 29566, 37208, 44850, 52492, 60134 anti-influenza_CDR 6641 14283, 21925, 29567, 37209, 44851, 52493, 60135 anti-influenza_CDR 6642 14284, 21926, 29568, 37210, 44852, 52494, 60136 anti-influenza_CDR 6643 14285, 21927, 29569, 37211, 44853, 52495, 60137 anti-influenza_CDR 6644 14286, 21928, 29570, 37212, 44854, 52496, 60138 anti-influenza_CDR 6645 14287, 21929, 29571, 37213, 44855, 52497, 60139 anti-influenza_CDR 6646 14288, 21930, 29572, 37214, 44856, 52498, 60140 anti-influenza_CDR 6647 14289, 21931, 29573, 37215, 44857, 52499, 60141 anti-influenza_CDR 6648 14290, 21932, 29574, 37216, 44858, 52500, 60142 anti-influenza_CDR 6649 14291, 21933, 29575, 37217, 44859, 52501, 60143 anti-influenza_CDR 6650 14292, 21934, 29576, 37218, 44860, 52502, 60144 anti-influenza_CDR 6651 14293, 21935, 29577, 37219, 44861, 52503, 60145 anti-influenza_CDR 6652 14294, 21936, 29578, 37220, 44862, 52504, 60146 anti-influenza_CDR 6653 14295, 21937, 29579, 37221, 44863, 52505, 60147 anti-influenza_CDR 6654 14296, 21938, 29580, 37222, 44864, 52506, 60148 anti-influenza_CDR 6655 14297, 21939, 29581, 37223, 44865, 52507, 60149 anti-influenza_CDR 6656 14298, 21940, 29582, 37224, 44866, 52508, 60150 anti-influenza_CDR 6657 14299, 21941, 29583, 37225, 44867, 52509, 60151 anti-influenza_CDR 6658 14300, 21942, 29584, 37226, 44868, 52510, 60152 anti-influenza_CDR 6659 14301, 21943, 29585, 37227, 44869, 52511, 60153 anti-influenza_CDR 6660 14302, 21944, 29586, 37228, 44870, 52512, 60154 anti-influenza_CDR 6661 14303, 21945, 29587, 37229, 44871, 52513, 60155 anti-influenza_CDR 6662 14304, 21946, 29588, 37230, 44872, 52514, 60156 anti-influenza_CDR 6663 14305, 21947, 29589, 37231, 44873, 52515, 60157 anti-influenza_CDR 6664 14306, 21948, 29590, 37232, 44874, 52516, 60158 anti-influenza_CDR 6665 14307, 21949, 29591, 37233, 44875, 52517, 60159 anti-influenza_CDR 6666 14308, 21950, 29592, 37234, 44876, 52518, 60160 anti-influenza_CDR 6667 14309, 21951, 29593, 37235, 44877, 52519, 60161 anti-influenza_CDR 6668 14310, 21952, 29594, 37236, 44878, 52520, 60162 anti-influenza_CDR 6669 14311, 21953, 29595, 37237, 44879, 52521, 60163 anti-influenza_CDR 6670 14312, 21954, 29596, 37238, 44880, 52522, 60164 anti-influenza_CDR 6671 14313, 21955, 29597, 37239, 44881, 52523, 60165 anti-influenza_CDR 6672 14314, 21956, 29598, 37240, 44882, 52524, 60166 anti-influenza_CDR 6673 14315, 21957, 29599, 37241, 44883, 52525, 60167 anti-influenza_CDR 6674 14316, 21958, 29600, 37242, 44884, 52526, 60168 anti-influenza_CDR 6675 14317, 21959, 29601, 37243, 44885, 52527, 60169 anti-influenza_CDR 6676 14318, 21960, 29602, 37244, 44886, 52528, 60170 anti-influenza_CDR 6677 14319, 21961, 29603, 37245, 44887, 52529, 60171 anti-influenza_CDR 6678 14320, 21962, 29604, 37246, 44888, 52530, 60172 anti-influenza_CDR 6679 14321, 21963, 29605, 37247, 44889, 52531, 60173 anti-influenza_CDR 6680 14322, 21964, 29606, 37248, 44890, 52532, 60174 anti-influenza_CDR 6681 14323, 21965, 29607, 37249, 44891, 52533, 60175 anti-influenza_CDR 6682 14324, 21966, 29608, 37250, 44892, 52534, 60176 anti-influenza_CDR 6683 14325, 21967, 29609, 37251, 44893, 52535, 60177 anti-influenza_CDR 6684 14326, 21968, 29610, 37252, 44894, 52536, 60178 anti-influenza_CDR 6685 14327, 21969, 29611, 37253, 44895, 52537, 60179 anti-influenza_CDR 6686 14328, 21970, 29612, 37254, 44896, 52538, 60180 anti-influenza_CDR 6687 14329, 21971, 29613, 37255, 44897, 52539, 60181 anti-influenza_CDR 6688 14330, 21972, 29614, 37256, 44898, 52540, 60182 anti-influenza_CDR 6689 14331, 21973, 29615, 37257, 44899, 52541, 60183 anti-influenza_CDR 6690 14332, 21974, 29616, 37258, 44900, 52542, 60184 anti-influenza_CDR 6691 14333, 21975, 29617, 37259, 44901, 52543, 60185 anti-influenza_CDR 6692 14334, 21976, 29618, 37260, 44902, 52544, 60186 anti-influenza_CDR 6693 14335, 21977, 29619, 37261, 44903, 52545, 60187 anti-influenza_CDR 6694 14336, 21978, 29620, 37262, 44904, 52546, 60188 anti-influenza_CDR 6695 14337, 21979, 29621, 37263, 44905, 52547, 60189 anti-influenza_CDR 6696 14338, 21980, 29622, 37264, 44906, 52548, 60190 anti-influenza_CDR 6697 14339, 21981, 29623, 37265, 44907, 52549, 60191 anti-influenza_CDR 6698 14340, 21982, 29624, 37266, 44908, 52550, 60192 anti-influenza_CDR 6699 14341, 21983, 29625, 37267, 44909, 52551, 60193 anti-influenza_CDR 6700 14342, 21984, 29626, 37268, 44910, 52552, 60194 anti-influenza_CDR 6701 14343, 21985, 29627, 37269, 44911, 52553, 60195 anti-influenza_CDR 6702 14344, 21986, 29628, 37270, 44912, 52554, 60196 anti-influenza_CDR 6703 14345, 21987, 29629, 37271, 44913, 52555, 60197 anti-influenza_CDR 6704 14346, 21988, 29630, 37272, 44914, 52556, 60198 anti-influenza_CDR 6705 14347, 21989, 29631, 37273, 44915, 52557, 60199 anti-influenza_CDR 6706 14348, 21990, 29632, 37274, 44916, 52558, 60200 anti-influenza_CDR 6707 14349, 21991, 29633, 37275, 44917, 52559, 60201 anti-influenza_CDR 6708 14350, 21992, 29634, 37276, 44918, 52560, 60202 anti-influenza_CDR 6709 14351, 21993, 29635, 37277, 44919, 52561, 60203 anti-influenza_CDR 6710 14352, 21994, 29636, 37278, 44920, 52562, 60204 anti-influenza_CDR 6711 14353, 21995, 29637, 37279, 44921, 52563, 60205 anti-influenza_CDR 6712 14354, 21996, 29638, 37280, 44922, 52564, 60206 anti-influenza_CDR 6713 14355, 21997, 29639, 37281, 44923, 52565, 60207 anti-influenza_CDR 6714 14356, 21998, 29640, 37282, 44924, 52566, 60208 anti-influenza_CDR 6715 14357, 21999, 29641, 37283, 44925, 52567, 60209 anti-influenza_CDR 6716 14358, 22000, 29642, 37284, 44926, 52568, 60210 anti-influenza_CDR 6717 14359, 22001, 29643, 37285, 44927, 52569, 60211 anti-influenza_CDR 6718 14360, 22002, 29644, 37286, 44928, 52570, 60212 anti-influenza_CDR 6719 14361, 22003, 29645, 37287, 44929, 52571, 60213 anti-influenza_CDR 6720 14362, 22004, 29646, 37288, 44930, 52572, 60214 anti-influenza_CDR 6721 14363, 22005, 29647, 37289, 44931, 52573, 60215 anti-influenza_CDR 6722 14364, 22006, 29648, 37290, 44932, 52574, 60216 anti-influenza_CDR 6723 14365, 22007, 29649, 37291, 44933, 52575, 60217 anti-influenza_CDR 6724 14366, 22008, 29650, 37292, 44934, 52576, 60218 anti-influenza_CDR 6725 14367, 22009, 29651, 37293, 44935, 52577, 60219 anti-influenza_CDR 6726 14368, 22010, 29652, 37294, 44936, 52578, 60220 anti-influenza_CDR 6727 14369, 22011, 29653, 37295, 44937, 52579, 60221 anti-influenza_CDR 6728 14370, 22012, 29654, 37296, 44938, 52580, 60222 anti-influenza_CDR 6729 14371, 22013, 29655, 37297, 44939, 52581, 60223 anti-influenza_CDR 6730 14372, 22014, 29656, 37298, 44940, 52582, 60224 anti-influenza_CDR 6731 14373, 22015, 29657, 37299, 44941, 52583, 60225 anti-influenza_CDR 6732 14374, 22016, 29658, 37300, 44942, 52584, 60226 anti-influenza_CDR 6733 14375, 22017, 29659, 37301, 44943, 52585, 60227 anti-influenza_CDR 6734 14376, 22018, 29660, 37302, 44944, 52586, 60228 anti-influenza_CDR 6735 14377, 22019, 29661, 37303, 44945, 52587, 60229 anti-influenza_CDR 6736 14378, 22020, 29662, 37304, 44946, 52588, 60230 anti-influenza_CDR 6737 14379, 22021, 29663, 37305, 44947, 52589, 60231 anti-influenza_CDR 6738 14380, 22022, 29664, 37306, 44948, 52590, 60232 anti-influenza_CDR 6739 14381, 22023, 29665, 37307, 44949, 52591, 60233 anti-influenza_CDR 6740 14382, 22024, 29666, 37308, 44950, 52592, 60234 anti-influenza_CDR 6741 14383, 22025, 29667, 37309, 44951, 52593, 60235 anti-influenza_CDR 6742 14384, 22026, 29668, 37310, 44952, 52594, 60236 anti-influenza_CDR 6743 14385, 22027, 29669, 37311, 44953, 52595, 60237 anti-influenza_CDR 6744 14386, 22028, 29670, 37312, 44954, 52596, 60238 anti-influenza_CDR 6745 14387, 22029, 29671, 37313, 44955, 52597, 60239 anti-influenza_CDR 6746 14388, 22030, 29672, 37314, 44956, 52598, 60240 anti-influenza_CDR 6747 14389, 22031, 29673, 37315, 44957, 52599, 60241 anti-influenza_CDR 6748 14390, 22032, 29674, 37316, 44958, 52600, 60242 anti-influenza_CDR 6749 14391, 22033, 29675, 37317, 44959, 52601, 60243 anti-influenza_CDR 6750 14392, 22034, 29676, 37318, 44960, 52602, 60244 anti-influenza_CDR 6751 14393, 22035, 29677, 37319, 44961, 52603, 60245 anti-influenza_CDR 6752 14394, 22036, 29678, 37320, 44962, 52604, 60246 anti-influenza_CDR 6753 14395, 22037, 29679, 37321, 44963, 52605, 60247 anti-influenza_CDR 6754 14396, 22038, 29680, 37322, 44964, 52606, 60248 anti-influenza_CDR 6755 14397, 22039, 29681, 37323, 44965, 52607, 60249 anti-influenza_CDR 6756 14398, 22040, 29682, 37324, 44966, 52608, 60250 anti-influenza_CDR 6757 14399, 22041, 29683, 37325, 44967, 52609, 60251 anti-influenza_CDR 6758 14400, 22042, 29684, 37326, 44968, 52610, 60252 anti-influenza_CDR 6759 14401, 22043, 29685, 37327, 44969, 52611, 60253 anti-influenza_CDR 6760 14402, 22044, 29686, 37328, 44970, 52612, 60254 anti-influenza_CDR 6761 14403, 22045, 29687, 37329, 44971, 52613, 60255 anti-influenza_CDR 6762 14404, 22046, 29688, 37330, 44972, 52614, 60256 anti-influenza_CDR 6763 14405, 22047, 29689, 37331, 44973, 52615, 60257 anti-influenza_CDR 6764 14406, 22048, 29690, 37332, 44974, 52616, 60258 anti-influenza_CDR 6765 14407, 22049, 29691, 37333, 44975, 52617, 60259 anti-influenza_CDR 6766 14408, 22050, 29692, 37334, 44976, 52618, 60260 anti-influenza_CDR 6767 14409, 22051, 29693, 37335, 44977, 52619, 60261 anti-influenza_CDR 6768 14410, 22052, 29694, 37336, 44978, 52620, 60262 anti-influenza_CDR 6769 14411, 22053, 29695, 37337, 44979, 52621, 60263 anti-influenza_CDR 6770 14412, 22054, 29696, 37338, 44980, 52622, 60264 anti-influenza_CDR 6771 14413, 22055, 29697, 37339, 44981, 52623, 60265 anti-influenza_CDR 6772 14414, 22056, 29698, 37340, 44982, 52624, 60266 anti-influenza_CDR 6773 14415, 22057, 29699, 37341, 44983, 52625, 60267 anti-influenza_CDR 6774 14416, 22058, 29700, 37342, 44984, 52626, 60268 anti-influenza_CDR 6775 14417, 22059, 29701, 37343, 44985, 52627, 60269 anti-influenza_CDR 6776 14418, 22060, 29702, 37344, 44986, 52628, 60270 anti-influenza_CDR 6777 14419, 22061, 29703, 37345, 44987, 52629, 60271 anti-influenza_CDR 6778 14420, 22062, 29704, 37346, 44988, 52630, 60272 anti-influenza_CDR 6779 14421, 22063, 29705, 37347, 44989, 52631, 60273 anti-influenza_CDR 6780 14422, 22064, 29706, 37348, 44990, 52632, 60274 anti-influenza_CDR 6781 14423, 22065, 29707, 37349, 44991, 52633, 60275 anti-influenza_CDR 6782 14424, 22066, 29708, 37350, 44992, 52634, 60276 anti-influenza_CDR 6783 14425, 22067, 29709, 37351, 44993, 52635, 60277 anti-influenza_CDR 6784 14426, 22068, 29710, 37352, 44994, 52636, 60278 anti-influenza_CDR 6785 14427, 22069, 29711, 37353, 44995, 52637, 60279 anti-influenza_CDR 6786 14428, 22070, 29712, 37354, 44996, 52638, 60280 anti-influenza_CDR 6787 14429, 22071, 29713, 37355, 44997, 52639, 60281 anti-influenza_CDR 6788 14430, 22072, 29714, 37356, 44998, 52640, 60282 anti-influenza_CDR 6789 14431, 22073, 29715, 37357, 44999, 52641, 60283 anti-influenza_CDR 6790 14432, 22074, 29716, 37358, 45000, 52642, 60284 anti-influenza_CDR 6791 14433, 22075, 29717, 37359, 45001, 52643, 60285 anti-influenza_CDR 6792 14434, 22076, 29718, 37360, 45002, 52644, 60286 anti-influenza_CDR 6793 14435, 22077, 29719, 37361, 45003, 52645, 60287 anti-influenza_CDR 6794 14436, 22078, 29720, 37362, 45004, 52646, 60288 anti-influenza_CDR 6795 14437, 22079, 29721, 37363, 45005, 52647, 60289 anti-influenza_CDR 6796 14438, 22080, 29722, 37364, 45006, 52648, 60290 anti-influenza_CDR 6797 14439, 22081, 29723, 37365, 45007, 52649, 60291 anti-influenza_CDR 6798 14440, 22082, 29724, 37366, 45008, 52650, 60292 anti-influenza_CDR 6799 14441, 22083, 29725, 37367, 45009, 52651, 60293 anti-influenza_CDR 6800 14442, 22084, 29726, 37368, 45010, 52652, 60294 anti-influenza_CDR 6801 14443, 22085, 29727, 37369, 45011, 52653, 60295 anti-influenza_CDR 6802 14444, 22086, 29728, 37370, 45012, 52654, 60296 anti-influenza_CDR 6803 14445, 22087, 29729, 37371, 45013, 52655, 60297 anti-influenza_CDR 6804 14446, 22088, 29730, 37372, 45014, 52656, 60298 anti-influenza_CDR 6805 14447, 22089, 29731, 37373, 45015, 52657, 60299 anti-influenza_CDR 6806 14448, 22090, 29732, 37374, 45016, 52658, 60300 anti-influenza_CDR 6807 14449, 22091, 29733, 37375, 45017, 52659, 60301 anti-influenza_CDR 6808 14450, 22092, 29734, 37376, 45018, 52660, 60302 anti-influenza_CDR 6809 14451, 22093, 29735, 37377, 45019, 52661, 60303 anti-influenza_CDR 6810 14452, 22094, 29736, 37378, 45020, 52662, 60304 anti-influenza_CDR 6811 14453, 22095, 29737, 37379, 45021, 52663, 60305 anti-influenza_CDR 6812 14454, 22096, 29738, 37380, 45022, 52664, 60306 anti-influenza_CDR 6813 14455, 22097, 29739, 37381, 45023, 52665, 60307 anti-influenza_CDR 6814 14456, 22098, 29740, 37382, 45024, 52666, 60308 anti-influenza_CDR 6815 14457, 22099, 29741, 37383, 45025, 52667, 60309 anti-influenza_CDR 6816 14458, 22100, 29742, 37384, 45026, 52668, 60310 anti-influenza_CDR 6817 14459, 22101, 29743, 37385, 45027, 52669, 60311 anti-influenza_CDR 6818 14460, 22102, 29744, 37386, 45028, 52670, 60312 anti-influenza_CDR 6819 14461, 22103, 29745, 37387, 45029, 52671, 60313 anti-influenza_CDR 6820 14462, 22104, 29746, 37388, 45030, 52672, 60314 anti-influenza_CDR 6821 14463, 22105, 29747, 37389, 45031, 52673, 60315 anti-influenza_CDR 6822 14464, 22106, 29748, 37390, 45032, 52674, 60316 anti-influenza_CDR 6823 14465, 22107, 29749, 37391, 45033, 52675, 60317 anti-influenza_CDR 6824 14466, 22108, 29750, 37392, 45034, 52676, 60318 anti-influenza_CDR 6825 14467, 22109, 29751, 37393, 45035, 52677, 60319 anti-influenza_CDR 6826 14468, 22110, 29752, 37394, 45036, 52678, 60320 anti-influenza_CDR 6827 14469, 22111, 29753, 37395, 45037, 52679, 60321 anti-influenza_CDR 6828 14470, 22112, 29754, 37396, 45038, 52680, 60322 anti-influenza_CDR 6829 14471, 22113, 29755, 37397, 45039, 52681, 60323 anti-influenza_CDR 6830 14472, 22114, 29756, 37398, 45040, 52682, 60324 anti-influenza_CDR 6831 14473, 22115, 29757, 37399, 45041, 52683, 60325 anti-influenza_CDR 6832 14474, 22116, 29758, 37400, 45042, 52684, 60326 anti-influenza_CDR 6833 14475, 22117, 29759, 37401, 45043, 52685, 60327 anti-influenza_CDR 6834 14476, 22118, 29760, 37402, 45044, 52686, 60328 anti-influenza_CDR 6835 14477, 22119, 29761, 37403, 45045, 52687, 60329 anti-influenza_CDR 6836 14478, 22120, 29762, 37404, 45046, 52688, 60330 anti-influenza_CDR 6837 14479, 22121, 29763, 37405, 45047, 52689, 60331 anti-influenza_CDR 6838 14480, 22122, 29764, 37406, 45048, 52690, 60332 anti-influenza_CDR 6839 14481, 22123, 29765, 37407, 45049, 52691, 60333 anti-influenza_CDR 6840 14482, 22124, 29766, 37408, 45050, 52692, 60334 anti-influenza_CDR 6841 14483, 22125, 29767, 37409, 45051, 52693, 60335 anti-influenza_CDR 6842 14484, 22126, 29768, 37410, 45052, 52694, 60336 anti-influenza_CDR 6843 14485, 22127, 29769, 37411, 45053, 52695, 60337 anti-influenza_CDR 6844 14486, 22128, 29770, 37412, 45054, 52696, 60338 anti-influenza_CDR 6845 14487, 22129, 29771, 37413, 45055, 52697, 60339 anti-influenza_CDR 6846 14488, 22130, 29772, 37414, 45056, 52698, 60340 anti-influenza_CDR 6847 14489, 22131, 29773, 37415, 45057, 52699, 60341 anti-influenza_CDR 6848 14490, 22132, 29774, 37416, 45058, 52700, 60342 anti-influenza_CDR 6849 14491, 22133, 29775, 37417, 45059, 52701, 60343 anti-influenza_CDR 6850 14492, 22134, 29776, 37418, 45060, 52702, 60344 anti-influenza_CDR 6851 14493, 22135, 29777, 37419, 45061, 52703, 60345 anti-influenza_CDR 6852 14494, 22136, 29778, 37420, 45062, 52704, 60346 anti-influenza_CDR 6853 14495, 22137, 29779, 37421, 45063, 52705, 60347 anti-influenza_CDR 6854 14496, 22138, 29780, 37422, 45064, 52706, 60348 anti-influenza_CDR 6855 14497, 22139, 29781, 37423, 45065, 52707, 60349 anti-influenza_CDR 6856 14498, 22140, 29782, 37424, 45066, 52708, 60350 anti-influenza_CDR 6857 14499, 22141, 29783, 37425, 45067, 52709, 60351 anti-influenza_CDR 6858 14500, 22142, 29784, 37426, 45068, 52710, 60352 anti-influenza_CDR 6859 14501, 22143, 29785, 37427, 45069, 52711, 60353 anti-influenza_CDR 6860 14502, 22144, 29786, 37428, 45070, 52712, 60354 anti-influenza_CDR 6861 14503, 22145, 29787, 37429, 45071, 52713, 60355 anti-influenza_CDR 6862 14504, 22146, 29788, 37430, 45072, 52714, 60356 anti-influenza_CDR 6863 14505, 22147, 29789, 37431, 45073, 52715, 60357 anti-influenza_CDR 6864 14506, 22148, 29790, 37432, 45074, 52716, 60358 anti-influenza_CDR 6865 14507, 22149, 29791, 37433, 45075, 52717, 60359 anti-influenza_CDR 6866 14508, 22150, 29792, 37434, 45076, 52718, 60360 anti-influenza_CDR 6867 14509, 22151, 29793, 37435, 45077, 52719, 60361 anti-influenza_CDR 6868 14510, 22152, 29794, 37436, 45078, 52720, 60362 anti-influenza_CDR 6869 14511, 22153, 29795, 37437, 45079, 52721, 60363 anti-influenza_CDR 6870 14512, 22154, 29796, 37438, 45080, 52722, 60364 anti-influenza_CDR 6871 14513, 22155, 29797, 37439, 45081, 52723, 60365 anti-influenza_CDR 6872 14514, 22156, 29798, 37440, 45082, 52724, 60366 anti-influenza_CDR 6873 14515, 22157, 29799, 37441, 45083, 52725, 60367 anti-influenza_CDR 6874 14516, 22158, 29800, 37442, 45084, 52726, 60368 anti-influenza_CDR 6875 14517, 22159, 29801, 37443, 45085, 52727, 60369 anti-influenza_CDR 6876 14518, 22160, 29802, 37444, 45086, 52728, 60370 anti-influenza_CDR 6877 14519, 22161, 29803, 37445, 45087, 52729, 60371 anti-influenza_CDR 6878 14520, 22162, 29804, 37446, 45088, 52730, 60372 anti-influenza_CDR 6879 14521, 22163, 29805, 37447, 45089, 52731, 60373 anti-influenza_CDR 6880 14522, 22164, 29806, 37448, 45090, 52732, 60374 anti-influenza_CDR 6881 14523, 22165, 29807, 37449, 45091, 52733, 60375 anti-influenza_CDR 6882 14524, 22166, 29808, 37450, 45092, 52734, 60376 anti-influenza_CDR 6883 14525, 22167, 29809, 37451, 45093, 52735, 60377 anti-influenza_CDR 6884 14526, 22168, 29810, 37452, 45094, 52736, 60378 anti-influenza_CDR 6885 14527, 22169, 29811, 37453, 45095, 52737, 60379 anti-influenza_CDR 6886 14528, 22170, 29812, 37454, 45096, 52738, 60380 anti-influenza_CDR 6887 14529, 22171, 29813, 37455, 45097, 52739, 60381 anti-influenza_CDR 6888 14530, 22172, 29814, 37456, 45098, 52740, 60382 anti-influenza_CDR 6889 14531, 22173, 29815, 37457, 45099, 52741, 60383 anti-influenza_CDR 6890 14532, 22174, 29816, 37458, 45100, 52742, 60384 anti-influenza_CDR 6891 14533, 22175, 29817, 37459, 45101, 52743, 60385 anti-influenza_CDR 6892 14534, 22176, 29818, 37460, 45102, 52744, 60386 anti-influenza_CDR 6893 14535, 22177, 29819, 37461, 45103, 52745, 60387 anti-influenza_CDR 6894 14536, 22178, 29820, 37462, 45104, 52746, 60388 anti-influenza_CDR 6895 14537, 22179, 29821, 37463, 45105, 52747, 60389 anti-influenza_CDR 6896 14538, 22180, 29822, 37464, 45106, 52748, 60390 anti-influenza_CDR 6897 14539, 22181, 29823, 37465, 45107, 52749, 60391 anti-influenza_CDR 6898 14540, 22182, 29824, 37466, 45108, 52750, 60392 anti-influenza_CDR 6899 14541, 22183, 29825, 37467, 45109, 52751, 60393 anti-influenza_CDR 6900 14542, 22184, 29826, 37468, 45110, 52752, 60394 anti-influenza_CDR 6901 14543, 22185, 29827, 37469, 45111, 52753, 60395 anti-influenza_CDR 6902 14544, 22186, 29828, 37470, 45112, 52754, 60396 anti-influenza_CDR 6903 14545, 22187, 29829, 37471, 45113, 52755, 60397 anti-influenza_CDR 6904 14546, 22188, 29830, 37472, 45114, 52756, 60398 anti-influenza_CDR 6905 14547, 22189, 29831, 37473, 45115, 52757, 60399 anti-influenza_CDR 6906 14548, 22190, 29832, 37474, 45116, 52758, 60400 anti-influenza_CDR 6907 14549, 22191, 29833, 37475, 45117, 52759, 60401 anti-influenza_CDR 6908 14550, 22192, 29834, 37476, 45118, 52760, 60402 anti-influenza_CDR 6909 14551, 22193, 29835, 37477, 45119, 52761, 60403 anti-influenza_CDR 6910 14552, 22194, 29836, 37478, 45120, 52762, 60404 anti-influenza_CDR 6911 14553, 22195, 29837, 37479, 45121, 52763, 60405 anti-influenza_CDR 6912 14554, 22196, 29838, 37480, 45122, 52764, 60406 anti-influenza_CDR 6913 14555, 22197, 29839, 37481, 45123, 52765, 60407 anti-influenza_CDR 6914 14556, 22198, 29840, 37482, 45124, 52766, 60408 anti-influenza_CDR 6915 14557, 22199, 29841, 37483, 45125, 52767, 60409 anti-influenza_CDR 6916 14558, 22200, 29842, 37484, 45126, 52768, 60410 anti-influenza_CDR 6917 14559, 22201, 29843, 37485, 45127, 52769, 60411 anti-influenza_CDR 6918 14560, 22202, 29844, 37486, 45128, 52770, 60412 anti-influenza_CDR 6919 14561, 22203, 29845, 37487, 45129, 52771, 60413 anti-influenza_CDR 6920 14562, 22204, 29846, 37488, 45130, 52772, 60414 anti-influenza_CDR 6921 14563, 22205, 29847, 37489, 45131, 52773, 60415 anti-influenza_CDR 6922 14564, 22206, 29848, 37490, 45132, 52774, 60416 anti-influenza_CDR 6923 14565, 22207, 29849, 37491, 45133, 52775, 60417 anti-influenza_CDR 6924 14566, 22208, 29850, 37492, 45134, 52776, 60418 anti-influenza_CDR 6925 14567, 22209, 29851, 37493, 45135, 52777, 60419 anti-influenza_CDR 6926 14568, 22210, 29852, 37494, 45136, 52778, 60420 anti-influenza_CDR 6927 14569, 22211, 29853, 37495, 45137, 52779, 60421 anti-influenza_CDR 6928 14570, 22212, 29854, 37496, 45138, 52780, 60422 anti-influenza_CDR 6929 14571, 22213, 29855, 37497, 45139, 52781, 60423 anti-influenza_CDR 6930 14572, 22214, 29856, 37498, 45140, 52782, 60424 anti-influenza_CDR 6931 14573, 22215, 29857, 37499, 45141, 52783, 60425 anti-influenza_CDR 6932 14574, 22216, 29858, 37500, 45142, 52784, 60426 anti-influenza_CDR 6933 14575, 22217, 29859, 37501, 45143, 52785, 60427 anti-influenza_CDR 6934 14576, 22218, 29860, 37502, 45144, 52786, 60428 anti-influenza_CDR 6935 14577, 22219, 29861, 37503, 45145, 52787, 60429 anti-influenza_CDR 6936 14578, 22220, 29862, 37504, 45146, 52788, 60430 anti-influenza_CDR 6937 14579, 22221, 29863, 37505, 45147, 52789, 60431 anti-influenza_CDR 6938 14580, 22222, 29864, 37506, 45148, 52790, 60432 anti-influenza_CDR 6939 14581, 22223, 29865, 37507, 45149, 52791, 60433 anti-influenza_CDR 6940 14582, 22224, 29866, 37508, 45150, 52792, 60434 anti-influenza_CDR 6941 14583, 22225, 29867, 37509, 45151, 52793, 60435 anti-influenza_CDR 6942 14584, 22226, 29868, 37510, 45152, 52794, 60436 anti-influenza_CDR 6943 14585, 22227, 29869, 37511, 45153, 52795, 60437 anti-influenza_CDR 6944 14586, 22228, 29870, 37512, 45154, 52796, 60438 anti-influenza_CDR 6945 14587, 22229, 29871, 37513, 45155, 52797, 60439 anti-influenza_CDR 6946 14588, 22230, 29872, 37514, 45156, 52798, 60440 anti-influenza_CDR 6947 14589, 22231, 29873, 37515, 45157, 52799, 60441 anti-influenza_CDR 6948 14590, 22232, 29874, 37516, 45158, 52800, 60442 anti-influenza_CDR 6949 14591, 22233, 29875, 37517, 45159, 52801, 60443 anti-influenza_CDR 6950 14592, 22234, 29876, 37518, 45160, 52802, 60444 anti-influenza_CDR 6951 14593, 22235, 29877, 37519, 45161, 52803, 60445 anti-influenza_CDR 6952 14594, 22236, 29878, 37520, 45162, 52804, 60446 anti-influenza_CDR 6953 14595, 22237, 29879, 37521, 45163, 52805, 60447 anti-influenza_CDR 6954 14596, 22238, 29880, 37522, 45164, 52806, 60448 anti-influenza_CDR 6955 14597, 22239, 29881, 37523, 45165, 52807, 60449 anti-influenza_CDR 6956 14598, 22240, 29882, 37524, 45166, 52808, 60450 anti-influenza_CDR 6957 14599, 22241, 29883, 37525, 45167, 52809, 60451 anti-influenza_CDR 6958 14600, 22242, 29884, 37526, 45168, 52810, 60452 anti-influenza_CDR 6959 14601, 22243, 29885, 37527, 45169, 52811, 60453 anti-influenza_CDR 6960 14602, 22244, 29886, 37528, 45170, 52812, 60454 anti-influenza_CDR 6961 14603, 22245, 29887, 37529, 45171, 52813, 60455 anti-influenza_CDR 6962 14604, 22246, 29888, 37530, 45172, 52814, 60456 anti-influenza_CDR 6963 14605, 22247, 29889, 37531, 45173, 52815, 60457 anti-influenza_CDR 6964 14606, 22248, 29890, 37532, 45174, 52816, 60458 anti-influenza_CDR 6965 14607, 22249, 29891, 37533, 45175, 52817, 60459 anti-influenza_CDR 6966 14608, 22250, 29892, 37534, 45176, 52818, 60460 anti-influenza_CDR 6967 14609, 22251, 29893, 37535, 45177, 52819, 60461 anti-influenza_CDR 6968 14610, 22252, 29894, 37536, 45178, 52820, 60462 anti-influenza_CDR 6969 14611, 22253, 29895, 37537, 45179, 52821, 60463 anti-influenza_CDR 6970 14612, 22254, 29896, 37538, 45180, 52822, 60464 anti-influenza_CDR 6971 14613, 22255, 29897, 37539, 45181, 52823, 60465 anti-influenza_CDR 6972 14614, 22256, 29898, 37540, 45182, 52824, 60466 anti-influenza_CDR 6973 14615, 22257, 29899, 37541, 45183, 52825, 60467 anti-influenza_CDR 6974 14616, 22258, 29900, 37542, 45184, 52826, 60468 anti-influenza_CDR 6975 14617, 22259, 29901, 37543, 45185, 52827, 60469 anti-influenza_CDR 6976 14618, 22260, 29902, 37544, 45186, 52828, 60470 anti-influenza_CDR 6977 14619, 22261, 29903, 37545, 45187, 52829, 60471 anti-influenza_CDR 6978 14620, 22262, 29904, 37546, 45188, 52830, 60472 anti-influenza_CDR 6979 14621, 22263, 29905, 37547, 45189, 52831, 60473 anti-influenza_CDR 6980 14622, 22264, 29906, 37548, 45190, 52832, 60474 anti-influenza_CDR 6981 14623, 22265, 29907, 37549, 45191, 52833, 60475 anti-influenza_CDR 6982 14624, 22266, 29908, 37550, 45192, 52834, 60476 anti-influenza_CDR 6983 14625, 22267, 29909, 37551, 45193, 52835, 60477 anti-influenza_CDR 6984 14626, 22268, 29910, 37552, 45194, 52836, 60478 anti-influenza_CDR 6985 14627, 22269, 29911, 37553, 45195, 52837, 60479 anti-influenza_CDR 6986 14628, 22270, 29912, 37554, 45196, 52838, 60480 anti-influenza_CDR 6987 14629, 22271, 29913, 37555, 45197, 52839, 60481 anti-influenza_CDR 6988 14630, 22272, 29914, 37556, 45198, 52840, 60482 anti-influenza_CDR 6989 14631, 22273, 29915, 37557, 45199, 52841, 60483 anti-influenza_CDR 6990 14632, 22274, 29916, 37558, 45200, 52842, 60484 anti-influenza_CDR 6991 14633, 22275, 29917, 37559, 45201, 52843, 60485 anti-influenza_CDR 6992 14634, 22276, 29918, 37560, 45202, 52844, 60486 anti-influenza_CDR 6993 14635, 22277, 29919, 37561, 45203, 52845, 60487 anti-influenza_CDR 6994 14636, 22278, 29920, 37562, 45204, 52846, 60488 anti-influenza_CDR 6995 14637, 22279, 29921, 37563, 45205, 52847, 60489 anti-influenza_CDR 6996 14638, 22280, 29922, 37564, 45206, 52848, 60490 anti-influenza_CDR 6997 14639, 22281, 29923, 37565, 45207, 52849, 60491 anti-influenza_CDR 6998 14640, 22282, 29924, 37566, 45208, 52850, 60492 anti-influenza_CDR 6999 14641, 22283, 29925, 37567, 45209, 52851, 60493 anti-influenza_CDR 7000 14642, 22284, 29926, 37568, 45210, 52852, 60494 anti-influenza_CDR 7001 14643, 22285, 29927, 37569, 45211, 52853, 60495 anti-influenza_CDR 7002 14644, 22286, 29928, 37570, 45212, 52854, 60496 anti-influenza_CDR 7003 14645, 22287, 29929, 37571, 45213, 52855, 60497 anti-influenza_CDR 7004 14646, 22288, 29930, 37572, 45214, 52856, 60498 anti-influenza_CDR 7005 14647, 22289, 29931, 37573, 45215, 52857, 60499 anti-influenza_CDR 7006 14648, 22290, 29932, 37574, 45216, 52858, 60500 anti-influenza_CDR 7007 14649, 22291, 29933, 37575, 45217, 52859, 60501 anti-influenza_CDR 7008 14650, 22292, 29934, 37576, 45218, 52860, 60502 anti-influenza_CDR 7009 14651, 22293, 29935, 37577, 45219, 52861, 60503 anti-influenza_CDR 7010 14652, 22294, 29936, 37578, 45220, 52862, 60504 anti-influenza_CDR 7011 14653, 22295, 29937, 37579, 45221, 52863, 60505 anti-influenza_CDR 7012 14654, 22296, 29938, 37580, 45222, 52864, 60506 anti-influenza_CDR 7013 14655, 22297, 29939, 37581, 45223, 52865, 60507 anti-influenza_CDR 7014 14656, 22298, 29940, 37582, 45224, 52866, 60508 anti-influenza_CDR 7015 14657, 22299, 29941, 37583, 45225, 52867, 60509 anti-influenza_CDR 7016 14658, 22300, 29942, 37584, 45226, 52868, 60510 anti-influenza_CDR 7017 14659, 22301, 29943, 37585, 45227, 52869, 60511 anti-influenza_CDR 7018 14660, 22302, 29944, 37586, 45228, 52870, 60512 anti-influenza_CDR 7019 14661, 22303, 29945, 37587, 45229, 52871, 60513 anti-influenza_CDR 7020 14662, 22304, 29946, 37588, 45230, 52872, 60514 anti-influenza_CDR 7021 14663, 22305, 29947, 37589, 45231, 52873, 60515 anti-influenza_CDR 7022 14664, 22306, 29948, 37590, 45232, 52874, 60516 anti-influenza_CDR 7023 14665, 22307, 29949, 37591, 45233, 52875, 60517 anti-influenza_CDR 7024 14666, 22308, 29950, 37592, 45234, 52876, 60518 anti-influenza_CDR 7025 14667, 22309, 29951, 37593, 45235, 52877, 60519 anti-influenza_CDR 7026 14668, 22310, 29952, 37594, 45236, 52878, 60520 anti-influenza_CDR 7027 14669, 22311, 29953, 37595, 45237, 52879, 60521 anti-influenza_CDR 7028 14670, 22312, 29954, 37596, 45238, 52880, 60522 anti-influenza_CDR 7029 14671, 22313, 29955, 37597, 45239, 52881, 60523 anti-influenza_CDR 7030 14672, 22314, 29956, 37598, 45240, 52882, 60524 anti-influenza_CDR 7031 14673, 22315, 29957, 37599, 45241, 52883, 60525 anti-influenza_CDR 7032 14674, 22316, 29958, 37600, 45242, 52884, 60526 anti-influenza_CDR 7033 14675, 22317, 29959, 37601, 45243, 52885, 60527 anti-influenza_CDR 7034 14676, 22318, 29960, 37602, 45244, 52886, 60528 anti-influenza_CDR 7035 14677, 22319, 29961, 37603, 45245, 52887, 60529 anti-influenza_CDR 7036 14678, 22320, 29962, 37604, 45246, 52888, 60530 anti-influenza_CDR 7037 14679, 22321, 29963, 37605, 45247, 52889, 60531 anti-influenza_CDR 7038 14680, 22322, 29964, 37606, 45248, 52890, 60532 anti-influenza_CDR 7039 14681, 22323, 29965, 37607, 45249, 52891, 60533 anti-influenza_CDR 7040 14682, 22324, 29966, 37608, 45250, 52892, 60534 anti-influenza_CDR 7041 14683, 22325, 29967, 37609, 45251, 52893, 60535 anti-influenza_CDR 7042 14684, 22326, 29968, 37610, 45252, 52894, 60536 anti-influenza_CDR 7043 14685, 22327, 29969, 37611, 45253, 52895, 60537 anti-influenza_CDR 7044 14686, 22328, 29970, 37612, 45254, 52896, 60538 anti-influenza_CDR 7045 14687, 22329, 29971, 37613, 45255, 52897, 60539 anti-influenza_CDR 7046 14688, 22330, 29972, 37614, 45256, 52898, 60540 anti-influenza_CDR 7047 14689, 22331, 29973, 37615, 45257, 52899, 60541 anti-influenza_CDR 7048 14690, 22332, 29974, 37616, 45258, 52900, 60542 anti-influenza_CDR 7049 14691, 22333, 29975, 37617, 45259, 52901, 60543 anti-influenza_CDR 7050 14692, 22334, 29976, 37618, 45260, 52902, 60544 anti-influenza_CDR 7051 14693, 22335, 29977, 37619, 45261, 52903, 60545 anti-influenza_CDR 7052 14694, 22336, 29978, 37620, 45262, 52904, 60546 anti-influenza_CDR 7053 14695, 22337, 29979, 37621, 45263, 52905, 60547 anti-influenza_CDR 7054 14696, 22338, 29980, 37622, 45264, 52906, 60548 anti-influenza_CDR 7055 14697, 22339, 29981, 37623, 45265, 52907, 60549 anti-influenza_CDR 7056 14698, 22340, 29982, 37624, 45266, 52908, 60550 anti-influenza_CDR 7057 14699, 22341, 29983, 37625, 45267, 52909, 60551 anti-influenza_CDR 7058 14700, 22342, 29984, 37626, 45268, 52910, 60552 anti-influenza_CDR 7059 14701, 22343, 29985, 37627, 45269, 52911, 60553 anti-influenza_CDR 7060 14702, 22344, 29986, 37628, 45270, 52912, 60554 anti-influenza_CDR 7061 14703, 22345, 29987, 37629, 45271, 52913, 60555 anti-influenza_CDR 7062 14704, 22346, 29988, 37630, 45272, 52914, 60556 anti-influenza_CDR 7063 14705, 22347, 29989, 37631, 45273, 52915, 60557 anti-influenza_CDR 7064 14706, 22348, 29990, 37632, 45274, 52916, 60558 anti-influenza_CDR 7065 14707, 22349, 29991, 37633, 45275, 52917, 60559 anti-influenza_CDR 7066 14708, 22350, 29992, 37634, 45276, 52918, 60560 anti-influenza_CDR 7067 14709, 22351, 29993, 37635, 45277, 52919, 60561 anti-influenza_CDR 7068 14710, 22352, 29994, 37636, 45278, 52920, 60562 anti-influenza_CDR 7069 14711, 22353, 29995, 37637, 45279, 52921, 60563 anti-influenza_CDR 7070 14712, 22354, 29996, 37638, 45280, 52922, 60564 anti-influenza_CDR 7071 14713, 22355, 29997, 37639, 45281, 52923, 60565 anti-influenza_CDR 7072 14714, 22356, 29998, 37640, 45282, 52924, 60566 anti-influenza_CDR 7073 14715, 22357, 29999, 37641, 45283, 52925, 60567 anti-influenza_CDR 7074 14716, 22358, 30000, 37642, 45284, 52926, 60568 anti-influenza_CDR 7075 14717, 22359, 30001, 37643, 45285, 52927, 60569 anti-influenza_CDR 7076 14718, 22360, 30002, 37644, 45286, 52928, 60570 anti-influenza_CDR 7077 14719, 22361, 30003, 37645, 45287, 52929, 60571 anti-influenza_CDR 7078 14720, 22362, 30004, 37646, 45288, 52930, 60572 anti-influenza_CDR 7079 14721, 22363, 30005, 37647, 45289, 52931, 60573 anti-influenza_CDR 7080 14722, 22364, 30006, 37648, 45290, 52932, 60574 anti-influenza_CDR 7081 14723, 22365, 30007, 37649, 45291, 52933, 60575 anti-influenza_CDR 7082 14724, 22366, 30008, 37650, 45292, 52934, 60576 anti-influenza_CDR 7083 14725, 22367, 30009, 37651, 45293, 52935, 60577 anti-influenza_CDR 7084 14726, 22368, 30010, 37652, 45294, 52936, 60578 anti-influenza_CDR 7085 14727, 22369, 30011, 37653, 45295, 52937, 60579 anti-influenza_CDR 7086 14728, 22370, 30012, 37654, 45296, 52938, 60580 anti-influenza_CDR 7087 14729, 22371, 30013, 37655, 45297, 52939, 60581 anti-influenza_CDR 7088 14730, 22372, 30014, 37656, 45298, 52940, 60582 anti-influenza_CDR 7089 14731, 22373, 30015, 37657, 45299, 52941, 60583 anti-influenza_CDR 7090 14732, 22374, 30016, 37658, 45300, 52942, 60584 anti-influenza_CDR 7091 14733, 22375, 30017, 37659, 45301, 52943, 60585 anti-influenza_CDR 7092 14734, 22376, 30018, 37660, 45302, 52944, 60586 anti-influenza_CDR 7093 14735, 22377, 30019, 37661, 45303, 52945, 60587 anti-influenza_CDR 7094 14736, 22378, 30020, 37662, 45304, 52946, 60588 anti-influenza_CDR 7095 14737, 22379, 30021, 37663, 45305, 52947, 60589 anti-influenza_CDR 7096 14738, 22380, 30022, 37664, 45306, 52948, 60590 anti-influenza_CDR 7097 14739, 22381, 30023, 37665, 45307, 52949, 60591 anti-influenza_CDR 7098 14740, 22382, 30024, 37666, 45308, 52950, 60592 anti-influenza_CDR 7099 14741, 22383, 30025, 37667, 45309, 52951, 60593 anti-influenza_CDR 7100 14742, 22384, 30026, 37668, 45310, 52952, 60594 anti-influenza_CDR 7101 14743, 22385, 30027, 37669, 45311, 52953, 60595 anti-influenza_CDR 7102 14744, 22386, 30028, 37670, 45312, 52954, 60596 anti-influenza_CDR 7103 14745, 22387, 30029, 37671, 45313, 52955, 60597 anti-influenza_CDR 7104 14746, 22388, 30030, 37672, 45314, 52956, 60598 anti-influenza_CDR 7105 14747, 22389, 30031, 37673, 45315, 52957, 60599 anti-influenza_CDR 7106 14748, 22390, 30032, 37674, 45316, 52958, 60600 anti-influenza_CDR 7107 14749, 22391, 30033, 37675, 45317, 52959, 60601 anti-influenza_CDR 7108 14750, 22392, 30034, 37676, 45318, 52960, 60602 anti-influenza_CDR 7109 14751, 22393, 30035, 37677, 45319, 52961, 60603 anti-influenza_CDR 7110 14752, 22394, 30036, 37678, 45320, 52962, 60604 anti-influenza_CDR 7111 14753, 22395, 30037, 37679, 45321, 52963, 60605 anti-influenza_CDR 7112 14754, 22396, 30038, 37680, 45322, 52964, 60606 anti-influenza_CDR 7113 14755, 22397, 30039, 37681, 45323, 52965, 60607 anti-influenza_CDR 7114 14756, 22398, 30040, 37682, 45324, 52966, 60608 anti-influenza_CDR 7115 14757, 22399, 30041, 37683, 45325, 52967, 60609 anti-influenza_CDR 7116 14758, 22400, 30042, 37684, 45326, 52968, 60610 anti-influenza_CDR 7117 14759, 22401, 30043, 37685, 45327, 52969, 60611 anti-influenza_CDR 7118 14760, 22402, 30044, 37686, 45328, 52970, 60612 anti-influenza_CDR 7119 14761, 22403, 30045, 37687, 45329, 52971, 60613 anti-influenza_CDR 7120 14762, 22404, 30046, 37688, 45330, 52972, 60614 anti-influenza_CDR 7121 14763, 22405, 30047, 37689, 45331, 52973, 60615 anti-influenza_CDR 7122 14764, 22406, 30048, 37690, 45332, 52974, 60616 anti-influenza_CDR 7123 14765, 22407, 30049, 37691, 45333, 52975, 60617 anti-influenza_CDR 7124 14766, 22408, 30050, 37692, 45334, 52976, 60618 anti-influenza_CDR 7125 14767, 22409, 30051, 37693, 45335, 52977, 60619 anti-influenza_CDR 7126 14768, 22410, 30052, 37694, 45336, 52978, 60620 anti-influenza_CDR 7127 14769, 22411, 30053, 37695, 45337, 52979, 60621 anti-influenza_CDR 7128 14770, 22412, 30054, 37696, 45338, 52980, 60622 anti-influenza_CDR 7129 14771, 22413, 30055, 37697, 45339, 52981, 60623 anti-influenza_CDR 7130 14772, 22414, 30056, 37698, 45340, 52982, 60624 anti-influenza_CDR 7131 14773, 22415, 30057, 37699, 45341, 52983, 60625 anti-influenza_CDR 7132 14774, 22416, 30058, 37700, 45342, 52984, 60626 anti-influenza_CDR 7133 14775, 22417, 30059, 37701, 45343, 52985, 60627 anti-influenza_CDR 7134 14776, 22418, 30060, 37702, 45344, 52986, 60628 anti-influenza_CDR 7135 14777, 22419, 30061, 37703, 45345, 52987, 60629 anti-influenza_CDR 7136 14778, 22420, 30062, 37704, 45346, 52988, 60630 anti-influenza_CDR 7137 14779, 22421, 30063, 37705, 45347, 52989, 60631 anti-influenza_CDR 7138 14780, 22422, 30064, 37706, 45348, 52990, 60632 anti-influenza_CDR 7139 14781, 22423, 30065, 37707, 45349, 52991, 60633 anti-influenza_CDR 7140 14782, 22424, 30066, 37708, 45350, 52992, 60634 anti-influenza_CDR 7141 14783, 22425, 30067, 37709, 45351, 52993, 60635 anti-influenza_CDR 7142 14784, 22426, 30068, 37710, 45352, 52994, 60636 anti-influenza_CDR 7143 14785, 22427, 30069, 37711, 45353, 52995, 60637 anti-influenza_CDR 7144 14786, 22428, 30070, 37712, 45354, 52996, 60638 anti-influenza_CDR 7145 14787, 22429, 30071, 37713, 45355, 52997, 60639 anti-influenza_CDR 7146 14788, 22430, 30072, 37714, 45356, 52998, 60640 anti-influenza_CDR 7147 14789, 22431, 30073, 37715, 45357, 52999, 60641 anti-influenza_CDR 7148 14790, 22432, 30074, 37716, 45358, 53000, 60642 anti-influenza_CDR 7149 14791, 22433, 30075, 37717, 45359, 53001, 60643 anti-influenza_CDR 7150 14792, 22434, 30076, 37718, 45360, 53002, 60644 anti-influenza_CDR 7151 14793, 22435, 30077, 37719, 45361, 53003, 60645 anti-influenza_CDR 7152 14794, 22436, 30078, 37720, 45362, 53004, 60646 anti-influenza_CDR 7153 14795, 22437, 30079, 37721, 45363, 53005, 60647 anti-influenza_CDR 7154 14796, 22438, 30080, 37722, 45364, 53006, 60648 anti-influenza_CDR 7155 14797, 22439, 30081, 37723, 45365, 53007, 60649 anti-influenza_CDR 7156 14798, 22440, 30082, 37724, 45366, 53008, 60650 anti-influenza_CDR 7157 14799, 22441, 30083, 37725, 45367, 53009, 60651 anti-influenza_CDR 7158 14800, 22442, 30084, 37726, 45368, 53010, 60652 anti-influenza_CDR 7159 14801, 22443, 30085, 37727, 45369, 53011, 60653 anti-influenza_CDR 7160 14802, 22444, 30086, 37728, 45370, 53012, 60654 anti-influenza_CDR 7161 14803, 22445, 30087, 37729, 45371, 53013, 60655 anti-influenza_CDR 7162 14804, 22446, 30088, 37730, 45372, 53014, 60656 anti-influenza_CDR 7163 14805, 22447, 30089, 37731, 45373, 53015, 60657 anti-influenza_CDR 7164 14806, 22448, 30090, 37732, 45374, 53016, 60658 anti-influenza_CDR 7165 14807, 22449, 30091, 37733, 45375, 53017, 60659 anti-influenza_CDR 7166 14808, 22450, 30092, 37734, 45376, 53018, 60660 anti-influenza_CDR 7167 14809, 22451, 30093, 37735, 45377, 53019, 60661 anti-influenza_CDR 7168 14810, 22452, 30094, 37736, 45378, 53020, 60662 anti-influenza_CDR 7169 14811, 22453, 30095, 37737, 45379, 53021, 60663 anti-influenza_CDR 7170 14812, 22454, 30096, 37738, 45380, 53022, 60664 anti-influenza_CDR 7171 14813, 22455, 30097, 37739, 45381, 53023, 60665 anti-influenza_CDR 7172 14814, 22456, 30098, 37740, 45382, 53024, 60666 anti-influenza_CDR 7173 14815, 22457, 30099, 37741, 45383, 53025, 60667 anti-influenza_CDR 7174 14816, 22458, 30100, 37742, 45384, 53026, 60668 anti-influenza_CDR 7175 14817, 22459, 30101, 37743, 45385, 53027, 60669 anti-influenza_CDR 7176 14818, 22460, 30102, 37744, 45386, 53028, 60670 anti-influenza_CDR 7177 14819, 22461, 30103, 37745, 45387, 53029, 60671 anti-influenza_CDR 7178 14820, 22462, 30104, 37746, 45388, 53030, 60672 anti-influenza_CDR 7179 14821, 22463, 30105, 37747, 45389, 53031, 60673 anti-influenza_CDR 7180 14822, 22464, 30106, 37748, 45390, 53032, 60674 anti-influenza_CDR 7181 14823, 22465, 30107, 37749, 45391, 53033, 60675 anti-influenza_CDR 7182 14824, 22466, 30108, 37750, 45392, 53034, 60676 anti-influenza_CDR 7183 14825, 22467, 30109, 37751, 45393, 53035, 60677 anti-influenza_CDR 7184 14826, 22468, 30110, 37752, 45394, 53036, 60678 anti-influenza_CDR 7185 14827, 22469, 30111, 37753, 45395, 53037, 60679 anti-influenza_CDR 7186 14828, 22470, 30112, 37754, 45396, 53038, 60680 anti-influenza_CDR 7187 14829, 22471, 30113, 37755, 45397, 53039, 60681 anti-influenza_CDR 7188 14830, 22472, 30114, 37756, 45398, 53040, 60682 anti-influenza_CDR 7189 14831, 22473, 30115, 37757, 45399, 53041, 60683 anti-influenza_CDR 7190 14832, 22474, 30116, 37758, 45400, 53042, 60684 anti-influenza_CDR 7191 14833, 22475, 30117, 37759, 45401, 53043, 60685 anti-influenza_CDR 7192 14834, 22476, 30118, 37760, 45402, 53044, 60686 anti-influenza_CDR 7193 14835, 22477, 30119, 37761, 45403, 53045, 60687 anti-influenza_CDR 7194 14836, 22478, 30120, 37762, 45404, 53046, 60688 anti-influenza_CDR 7195 14837, 22479, 30121, 37763, 45405, 53047, 60689 anti-influenza_CDR 7196 14838, 22480, 30122, 37764, 45406, 53048, 60690 anti-influenza_CDR 7197 14839, 22481, 30123, 37765, 45407, 53049, 60691 anti-influenza_CDR 7198 14840, 22482, 30124, 37766, 45408, 53050, 60692 anti-influenza_CDR 7199 14841, 22483, 30125, 37767, 45409, 53051, 60693 anti-influenza_CDR 7200 14842, 22484, 30126, 37768, 45410, 53052, 60694 anti-influenza_CDR 7201 14843, 22485, 30127, 37769, 45411, 53053, 60695 anti-influenza_CDR 7202 14844, 22486, 30128, 37770, 45412, 53054, 60696 anti-influenza_CDR 7203 14845, 22487, 30129, 37771, 45413, 53055, 60697 anti-influenza_CDR 7204 14846, 22488, 30130, 37772, 45414, 53056, 60698 anti-influenza_CDR 7205 14847, 22489, 30131, 37773, 45415, 53057, 60699 anti-influenza_CDR 7206 14848, 22490, 30132, 37774, 45416, 53058, 60700 anti-influenza_CDR 7207 14849, 22491, 30133, 37775, 45417, 53059, 60701 anti-influenza_CDR 7208 14850, 22492, 30134, 37776, 45418, 53060, 60702 anti-influenza_CDR 7209 14851, 22493, 30135, 37777, 45419, 53061, 60703 anti-influenza_CDR 7210 14852, 22494, 30136, 37778, 45420, 53062, 60704 anti-influenza_CDR 7211 14853, 22495, 30137, 37779, 45421, 53063, 60705 anti-influenza_CDR 7212 14854, 22496, 30138, 37780, 45422, 53064, 60706 anti-influenza_CDR 7213 14855, 22497, 30139, 37781, 45423, 53065, 60707 anti-influenza_CDR 7214 14856, 22498, 30140, 37782, 45424, 53066, 60708 anti-influenza_CDR 7215 14857, 22499, 30141, 37783, 45425, 53067, 60709 anti-influenza_CDR 7216 14858, 22500, 30142, 37784, 45426, 53068, 60710 anti-influenza_CDR 7217 14859, 22501, 30143, 37785, 45427, 53069, 60711 anti-influenza_CDR 7218 14860, 22502, 30144, 37786, 45428, 53070, 60712 anti-influenza_CDR 7219 14861, 22503, 30145, 37787, 45429, 53071, 60713 anti-influenza_CDR 7220 14862, 22504, 30146, 37788, 45430, 53072, 60714 anti-influenza_CDR 7221 14863, 22505, 30147, 37789, 45431, 53073, 60715 anti-influenza_CDR 7222 14864, 22506, 30148, 37790, 45432, 53074, 60716 anti-influenza_CDR 7223 14865, 22507, 30149, 37791, 45433, 53075, 60717 anti-influenza_CDR 7224 14866, 22508, 30150, 37792, 45434, 53076, 60718 anti-influenza_CDR 7225 14867, 22509, 30151, 37793, 45435, 53077, 60719 anti-influenza_CDR 7226 14868, 22510, 30152, 37794, 45436, 53078, 60720 anti-influenza_CDR 7227 14869, 22511, 30153, 37795, 45437, 53079, 60721 anti-influenza_CDR 7228 14870, 22512, 30154, 37796, 45438, 53080, 60722 anti-influenza_CDR 7229 14871, 22513, 30155, 37797, 45439, 53081, 60723 anti-influenza_CDR 7230 14872, 22514, 30156, 37798, 45440, 53082, 60724 anti-influenza_CDR 7231 14873, 22515, 30157, 37799, 45441, 53083, 60725 anti-influenza_CDR 7232 14874, 22516, 30158, 37800, 45442, 53084, 60726 anti-influenza_CDR 7233 14875, 22517, 30159, 37801, 45443, 53085, 60727 anti-influenza_CDR 7234 14876, 22518, 30160, 37802, 45444, 53086, 60728 anti-influenza_CDR 7235 14877, 22519, 30161, 37803, 45445, 53087, 60729 anti-influenza_CDR 7236 14878, 22520, 30162, 37804, 45446, 53088, 60730 anti-influenza_CDR 7237 14879, 22521, 30163, 37805, 45447, 53089, 60731 anti-influenza_CDR 7238 14880, 22522, 30164, 37806, 45448, 53090, 60732 anti-influenza_CDR 7239 14881, 22523, 30165, 37807, 45449, 53091, 60733 anti-influenza_CDR 7240 14882, 22524, 30166, 37808, 45450, 53092, 60734 anti-influenza_CDR 7241 14883, 22525, 30167, 37809, 45451, 53093, 60735 anti-influenza_CDR 7242 14884, 22526, 30168, 37810, 45452, 53094, 60736 anti-influenza_CDR 7243 14885, 22527, 30169, 37811, 45453, 53095, 60737 anti-influenza_CDR 7244 14886, 22528, 30170, 37812, 45454, 53096, 60738 anti-influenza_CDR 7245 14887, 22529, 30171, 37813, 45455, 53097, 60739 anti-influenza_CDR 7246 14888, 22530, 30172, 37814, 45456, 53098, 60740 anti-influenza_CDR 7247 14889, 22531, 30173, 37815, 45457, 53099, 60741 anti-influenza_CDR 7248 14890, 22532, 30174, 37816, 45458, 53100, 60742 anti-influenza_CDR 7249 14891, 22533, 30175, 37817, 45459, 53101, 60743 anti-influenza_CDR 7250 14892, 22534, 30176, 37818, 45460, 53102, 60744 anti-influenza_CDR 7251 14893, 22535, 30177, 37819, 45461, 53103, 60745 anti-influenza_CDR 7252 14894, 22536, 30178, 37820, 45462, 53104, 60746 anti-influenza_CDR 7253 14895, 22537, 30179, 37821, 45463, 53105, 60747 anti-influenza_CDR 7254 14896, 22538, 30180, 37822, 45464, 53106, 60748 anti-influenza_CDR 7255 14897, 22539, 30181, 37823, 45465, 53107, 60749 anti-influenza_CDR 7256 14898, 22540, 30182, 37824, 45466, 53108, 60750 anti-influenza_CDR 7257 14899, 22541, 30183, 37825, 45467, 53109, 60751 anti-influenza_CDR 7258 14900, 22542, 30184, 37826, 45468, 53110, 60752 anti-influenza_CDR 7259 14901, 22543, 30185, 37827, 45469, 53111, 60753 anti-influenza_CDR 7260 14902, 22544, 30186, 37828, 45470, 53112, 60754 anti-influenza_CDR 7261 14903, 22545, 30187, 37829, 45471, 53113, 60755 anti-influenza_CDR 7262 14904, 22546, 30188, 37830, 45472, 53114, 60756 anti-influenza_CDR 7263 14905, 22547, 30189, 37831, 45473, 53115, 60757 anti-influenza_CDR 7264 14906, 22548, 30190, 37832, 45474, 53116, 60758 anti-influenza_CDR 7265 14907, 22549, 30191, 37833, 45475, 53117, 60759 anti-influenza_CDR 7266 14908, 22550, 30192, 37834, 45476, 53118, 60760 anti-influenza_CDR 7267 14909, 22551, 30193, 37835, 45477, 53119, 60761 anti-influenza_CDR 7268 14910, 22552, 30194, 37836, 45478, 53120, 60762 anti-influenza_CDR 7269 14911, 22553, 30195, 37837, 45479, 53121, 60763 anti-influenza_CDR 7270 14912, 22554, 30196, 37838, 45480, 53122, 60764 anti-influenza_CDR 7271 14913, 22555, 30197, 37839, 45481, 53123, 60765 anti-influenza_CDR 7272 14914, 22556, 30198, 37840, 45482, 53124, 60766 anti-influenza_CDR 7273 14915, 22557, 30199, 37841, 45483, 53125, 60767 anti-influenza_CDR 7274 14916, 22558, 30200, 37842, 45484, 53126, 60768 anti-influenza_CDR 7275 14917, 22559, 30201, 37843, 45485, 53127, 60769 anti-influenza_CDR 7276 14918, 22560, 30202, 37844, 45486, 53128, 60770 anti-influenza_CDR 7277 14919, 22561, 30203, 37845, 45487, 53129, 60771 anti-influenza_CDR 7278 14920, 22562, 30204, 37846, 45488, 53130, 60772 anti-influenza_CDR 7279 14921, 22563, 30205, 37847, 45489, 53131, 60773 anti-influenza_CDR 7280 14922, 22564, 30206, 37848, 45490, 53132, 60774 anti-influenza_CDR 7281 14923, 22565, 30207, 37849, 45491, 53133, 60775 anti-influenza_CDR 7282 14924, 22566, 30208, 37850, 45492, 53134, 60776 anti-influenza_CDR 7283 14925, 22567, 30209, 37851, 45493, 53135, 60777 anti-influenza_CDR 7284 14926, 22568, 30210, 37852, 45494, 53136, 60778 anti-influenza_CDR 7285 14927, 22569, 30211, 37853, 45495, 53137, 60779 anti-influenza_CDR 7286 14928, 22570, 30212, 37854, 45496, 53138, 60780 anti-influenza_CDR 7287 14929, 22571, 30213, 37855, 45497, 53139, 60781 anti-influenza_CDR 7288 14930, 22572, 30214, 37856, 45498, 53140, 60782 anti-influenza_CDR 7289 14931, 22573, 30215, 37857, 45499, 53141, 60783 anti-influenza_CDR 7290 14932, 22574, 30216, 37858, 45500, 53142, 60784 anti-influenza_CDR 7291 14933, 22575, 30217, 37859, 45501, 53143, 60785 anti-influenza_CDR 7292 14934, 22576, 30218, 37860, 45502, 53144, 60786 anti-influenza_CDR 7293 14935, 22577, 30219, 37861, 45503, 53145, 60787 anti-influenza_CDR 7294 14936, 22578, 30220, 37862, 45504, 53146, 60788 anti-influenza_CDR 7295 14937, 22579, 30221, 37863, 45505, 53147, 60789 anti-influenza_CDR 7296 14938, 22580, 30222, 37864, 45506, 53148, 60790 anti-influenza_CDR 7297 14939, 22581, 30223, 37865, 45507, 53149, 60791 anti-influenza_CDR 7298 14940, 22582, 30224, 37866, 45508, 53150, 60792 anti-influenza_CDR 7299 14941, 22583, 30225, 37867, 45509, 53151, 60793 anti-influenza_CDR 7300 14942, 22584, 30226, 37868, 45510, 53152, 60794 anti-influenza_CDR 7301 14943, 22585, 30227, 37869, 45511, 53153, 60795 anti-influenza_CDR 7302 14944, 22586, 30228, 37870, 45512, 53154, 60796 anti-influenza_CDR 7303 14945, 22587, 30229, 37871, 45513, 53155, 60797 anti-influenza_CDR 7304 14946, 22588, 30230, 37872, 45514, 53156, 60798 anti-influenza_CDR 7305 14947, 22589, 30231, 37873, 45515, 53157, 60799 anti-influenza_CDR 7306 14948, 22590, 30232, 37874, 45516, 53158, 60800 anti-influenza_CDR 7307 14949, 22591, 30233, 37875, 45517, 53159, 60801 anti-influenza_CDR 7308 14950, 22592, 30234, 37876, 45518, 53160, 60802 anti-influenza_CDR 7309 14951, 22593, 30235, 37877, 45519, 53161, 60803 anti-influenza_CDR 7310 14952, 22594, 30236, 37878, 45520, 53162, 60804 anti-influenza_CDR 7311 14953, 22595, 30237, 37879, 45521, 53163, 60805 anti-influenza_CDR 7312 14954, 22596, 30238, 37880, 45522, 53164, 60806 anti-influenza_CDR 7313 14955, 22597, 30239, 37881, 45523, 53165, 60807 anti-influenza_CDR 7314 14956, 22598, 30240, 37882, 45524, 53166, 60808 anti-influenza_CDR 7315 14957, 22599, 30241, 37883, 45525, 53167, 60809 anti-influenza_CDR 7316 14958, 22600, 30242, 37884, 45526, 53168, 60810 anti-influenza_CDR 7317 14959, 22601, 30243, 37885, 45527, 53169, 60811 anti-influenza_CDR 7318 14960, 22602, 30244, 37886, 45528, 53170, 60812 anti-influenza_CDR 7319 14961, 22603, 30245, 37887, 45529, 53171, 60813 anti-influenza_CDR 7320 14962, 22604, 30246, 37888, 45530, 53172, 60814 anti-influenza_CDR 7321 14963, 22605, 30247, 37889, 45531, 53173, 60815 anti-influenza_CDR 7322 14964, 22606, 30248, 37890, 45532, 53174, 60816 anti-influenza_CDR 7323 14965, 22607, 30249, 37891, 45533, 53175, 60817 anti-influenza_CDR 7324 14966, 22608, 30250, 37892, 45534, 53176, 60818 anti-influenza_CDR 7325 14967, 22609, 30251, 37893, 45535, 53177, 60819 anti-influenza_CDR 7326 14968, 22610, 30252, 37894, 45536, 53178, 60820 anti-influenza_CDR 7327 14969, 22611, 30253, 37895, 45537, 53179, 60821 anti-influenza_CDR 7328 14970, 22612, 30254, 37896, 45538, 53180, 60822 anti-influenza_CDR 7329 14971, 22613, 30255, 37897, 45539, 53181, 60823 anti-influenza_CDR 7330 14972, 22614, 30256, 37898, 45540, 53182, 60824 anti-influenza_CDR 7331 14973, 22615, 30257, 37899, 45541, 53183, 60825 anti-influenza_CDR 7332 14974, 22616, 30258, 37900, 45542, 53184, 60826 anti-influenza_CDR 7333 14975, 22617, 30259, 37901, 45543, 53185, 60827 anti-influenza_CDR 7334 14976, 22618, 30260, 37902, 45544, 53186, 60828 anti-influenza_CDR 7335 14977, 22619, 30261, 37903, 45545, 53187, 60829 anti-influenza_CDR 7336 14978, 22620, 30262, 37904, 45546, 53188, 60830 anti-influenza_CDR 7337 14979, 22621, 30263, 37905, 45547, 53189, 60831 anti-influenza_CDR 7338 14980, 22622, 30264, 37906, 45548, 53190, 60832 anti-influenza_CDR 7339 14981, 22623, 30265, 37907, 45549, 53191, 60833 anti-influenza_CDR 7340 14982, 22624, 30266, 37908, 45550, 53192, 60834 anti-influenza_CDR 7341 14983, 22625, 30267, 37909, 45551, 53193, 60835 anti-influenza_CDR 7342 14984, 22626, 30268, 37910, 45552, 53194, 60836 anti-influenza_CDR 7343 14985, 22627, 30269, 37911, 45553, 53195, 60837 anti-influenza_CDR 7344 14986, 22628, 30270, 37912, 45554, 53196, 60838 anti-influenza_CDR 7345 14987, 22629, 30271, 37913, 45555, 53197, 60839 anti-influenza_CDR 7346 14988, 22630, 30272, 37914, 45556, 53198, 60840 anti-influenza_CDR 7347 14989, 22631, 30273, 37915, 45557, 53199, 60841 anti-influenza_CDR 7348 14990, 22632, 30274, 37916, 45558, 53200, 60842 anti-influenza_CDR 7349 14991, 22633, 30275, 37917, 45559, 53201, 60843 anti-influenza_CDR 7350 14992, 22634, 30276, 37918, 45560, 53202, 60844 anti-influenza_CDR 7351 14993, 22635, 30277, 37919, 45561, 53203, 60845 anti-influenza_CDR 7352 14994, 22636, 30278, 37920, 45562, 53204, 60846 anti-influenza_CDR 7353 14995, 22637, 30279, 37921, 45563, 53205, 60847 anti-influenza_CDR 7354 14996, 22638, 30280, 37922, 45564, 53206, 60848 anti-influenza_CDR 7355 14997, 22639, 30281, 37923, 45565, 53207, 60849 anti-influenza_CDR 7356 14998, 22640, 30282, 37924, 45566, 53208, 60850 anti-influenza_CDR 7357 14999, 22641, 30283, 37925, 45567, 53209, 60851 anti-influenza_CDR 7358 15000, 22642, 30284, 37926, 45568, 53210, 60852 anti-influenza_CDR 7359 15001, 22643, 30285, 37927, 45569, 53211, 60853 anti-influenza_CDR 7360 15002, 22644, 30286, 37928, 45570, 53212, 60854 anti-influenza_CDR 7361 15003, 22645, 30287, 37929, 45571, 53213, 60855 anti-influenza_CDR 7362 15004, 22646, 30288, 37930, 45572, 53214, 60856 anti-influenza_CDR 7363 15005, 22647, 30289, 37931, 45573, 53215, 60857 anti-influenza_CDR 7364 15006, 22648, 30290, 37932, 45574, 53216, 60858 anti-influenza_CDR 7365 15007, 22649, 30291, 37933, 45575, 53217, 60859 anti-influenza_CDR 7366 15008, 22650, 30292, 37934, 45576, 53218, 60860 anti-influenza_CDR 7367 15009, 22651, 30293, 37935, 45577, 53219, 60861 anti-influenza_CDR 7368 15010, 22652, 30294, 37936, 45578, 53220, 60862 anti-influenza_CDR 7369 15011, 22653, 30295, 37937, 45579, 53221, 60863 anti-influenza_CDR 7370 15012, 22654, 30296, 37938, 45580, 53222, 60864 anti-influenza_CDR 7371 15013, 22655, 30297, 37939, 45581, 53223, 60865 anti-influenza_CDR 7372 15014, 22656, 30298, 37940, 45582, 53224, 60866 anti-influenza_CDR 7373 15015, 22657, 30299, 37941, 45583, 53225, 60867 anti-influenza_CDR 7374 15016, 22658, 30300, 37942, 45584, 53226, 60868 anti-influenza_CDR 7375 15017, 22659, 30301, 37943, 45585, 53227, 60869 anti-influenza_CDR 7376 15018, 22660, 30302, 37944, 45586, 53228, 60870 anti-influenza_CDR 7377 15019, 22661, 30303, 37945, 45587, 53229, 60871 anti-influenza_CDR 7378 15020, 22662, 30304, 37946, 45588, 53230, 60872 anti-influenza_CDR 7379 15021, 22663, 30305, 37947, 45589, 53231, 60873 anti-influenza_CDR 7380 15022, 22664, 30306, 37948, 45590, 53232, 60874 anti-influenza_CDR 7381 15023, 22665, 30307, 37949, 45591, 53233, 60875 anti-influenza_CDR 7382 15024, 22666, 30308, 37950, 45592, 53234, 60876 anti-influenza_CDR 7383 15025, 22667, 30309, 37951, 45593, 53235, 60877 anti-influenza_CDR 7384 15026, 22668, 30310, 37952, 45594, 53236, 60878 anti-influenza_CDR 7385 15027, 22669, 30311, 37953, 45595, 53237, 60879 anti-influenza_CDR 7386 15028, 22670, 30312, 37954, 45596, 53238, 60880 anti-influenza_CDR 7387 15029, 22671, 30313, 37955, 45597, 53239, 60881 anti-influenza_CDR 7388 15030, 22672, 30314, 37956, 45598, 53240, 60882 anti-influenza_CDR 7389 15031, 22673, 30315, 37957, 45599, 53241, 60883 anti-influenza_CDR 7390 15032, 22674, 30316, 37958, 45600, 53242, 60884 anti-influenza_CDR 7391 15033, 22675, 30317, 37959, 45601, 53243, 60885 anti-influenza_CDR 7392 15034, 22676, 30318, 37960, 45602, 53244, 60886 anti-influenza_CDR 7393 15035, 22677, 30319, 37961, 45603, 53245, 60887 anti-influenza_CDR 7394 15036, 22678, 30320, 37962, 45604, 53246, 60888 anti-influenza_CDR 7395 15037, 22679, 30321, 37963, 45605, 53247, 60889 anti-influenza_CDR 7396 15038, 22680, 30322, 37964, 45606, 53248, 60890 anti-influenza_CDR 7397 15039, 22681, 30323, 37965, 45607, 53249, 60891 anti-influenza_CDR 7398 15040, 22682, 30324, 37966, 45608, 53250, 60892 anti-influenza_CDR 7399 15041, 22683, 30325, 37967, 45609, 53251, 60893 anti-influenza_CDR 7400 15042, 22684, 30326, 37968, 45610, 53252, 60894 anti-influenza_CDR 7401 15043, 22685, 30327, 37969, 45611, 53253, 60895 anti-influenza_CDR 7402 15044, 22686, 30328, 37970, 45612, 53254, 60896 anti-influenza_CDR 7403 15045, 22687, 30329, 37971, 45613, 53255, 60897 anti-influenza_CDR 7404 15046, 22688, 30330, 37972, 45614, 53256, 60898 anti-influenza_CDR 7405 15047, 22689, 30331, 37973, 45615, 53257, 60899 anti-influenza_CDR 7406 15048, 22690, 30332, 37974, 45616, 53258, 60900 anti-influenza_CDR 7407 15049, 22691, 30333, 37975, 45617, 53259, 60901 anti-influenza_CDR 7408 15050, 22692, 30334, 37976, 45618, 53260, 60902 anti-influenza_CDR 7409 15051, 22693, 30335, 37977, 45619, 53261, 60903 anti-influenza_CDR 7410 15052, 22694, 30336, 37978, 45620, 53262, 60904 anti-influenza_CDR 7411 15053, 22695, 30337, 37979, 45621, 53263, 60905 anti-influenza_CDR 7412 15054, 22696, 30338, 37980, 45622, 53264, 60906 anti-influenza_CDR 7413 15055, 22697, 30339, 37981, 45623, 53265, 60907 anti-influenza_CDR 7414 15056, 22698, 30340, 37982, 45624, 53266, 60908 anti-influenza_CDR 7415 15057, 22699, 30341, 37983, 45625, 53267, 60909 anti-influenza_CDR 7416 15058, 22700, 30342, 37984, 45626, 53268, 60910 anti-influenza_CDR 7417 15059, 22701, 30343, 37985, 45627, 53269, 60911 anti-influenza_CDR 7418 15060, 22702, 30344, 37986, 45628, 53270, 60912 anti-influenza_CDR 7419 15061, 22703, 30345, 37987, 45629, 53271, 60913 anti-influenza_CDR 7420 15062, 22704, 30346, 37988, 45630, 53272, 60914 anti-influenza_CDR 7421 15063, 22705, 30347, 37989, 45631, 53273, 60915 anti-influenza_CDR 7422 15064, 22706, 30348, 37990, 45632, 53274, 60916 anti-influenza_CDR 7423 15065, 22707, 30349, 37991, 45633, 53275, 60917 anti-influenza_CDR 7424 15066, 22708, 30350, 37992, 45634, 53276, 60918 anti-influenza_CDR 7425 15067, 22709, 30351, 37993, 45635, 53277, 60919 anti-influenza_CDR 7426 15068, 22710, 30352, 37994, 45636, 53278, 60920 anti-influenza_CDR 7427 15069, 22711, 30353, 37995, 45637, 53279, 60921 anti-influenza_CDR 7428 15070, 22712, 30354, 37996, 45638, 53280, 60922 anti-influenza_CDR 7429 15071, 22713, 30355, 37997, 45639, 53281, 60923 anti-influenza_CDR 7430 15072, 22714, 30356, 37998, 45640, 53282, 60924 anti-influenza_CDR 7431 15073, 22715, 30357, 37999, 45641, 53283, 60925 anti-influenza_CDR 7432 15074, 22716, 30358, 38000, 45642, 53284, 60926 anti-influenza_CDR 7433 15075, 22717, 30359, 38001, 45643, 53285, 60927 anti-influenza_CDR 7434 15076, 22718, 30360, 38002, 45644, 53286, 60928 anti-influenza_CDR 7435 15077, 22719, 30361, 38003, 45645, 53287, 60929 anti-influenza_CDR 7436 15078, 22720, 30362, 38004, 45646, 53288, 60930 anti-influenza_CDR 7437 15079, 22721, 30363, 38005, 45647, 53289, 60931 anti-influenza_CDR 7438 15080, 22722, 30364, 38006, 45648, 53290, 60932 anti-influenza_CDR 7439 15081, 22723, 30365, 38007, 45649, 53291, 60933 anti-influenza_CDR 7440 15082, 22724, 30366, 38008, 45650, 53292, 60934 anti-influenza_CDR 7441 15083, 22725, 30367, 38009, 45651, 53293, 60935 anti-influenza_CDR 7442 15084, 22726, 30368, 38010, 45652, 53294, 60936 anti-influenza_CDR 7443 15085, 22727, 30369, 38011, 45653, 53295, 60937 anti-influenza_CDR 7444 15086, 22728, 30370, 38012, 45654, 53296, 60938 anti-influenza_CDR 7445 15087, 22729, 30371, 38013, 45655, 53297, 60939 anti-influenza_CDR 7446 15088, 22730, 30372, 38014, 45656, 53298, 60940 anti-influenza_CDR 7447 15089, 22731, 30373, 38015, 45657, 53299, 60941 anti-influenza_CDR 7448 15090, 22732, 30374, 38016, 45658, 53300, 60942 anti-influenza_CDR 7449 15091, 22733, 30375, 38017, 45659, 53301, 60943 anti-influenza_CDR 7450 15092, 22734, 30376, 38018, 45660, 53302, 60944 anti-influenza_CDR 7451 15093, 22735, 30377, 38019, 45661, 53303, 60945 anti-influenza_CDR 7452 15094, 22736, 30378, 38020, 45662, 53304, 60946 anti-influenza_CDR 7453 15095, 22737, 30379, 38021, 45663, 53305, 60947 anti-influenza_CDR 7454 15096, 22738, 30380, 38022, 45664, 53306, 60948 anti-influenza_CDR 7455 15097, 22739, 30381, 38023, 45665, 53307, 60949 anti-influenza_CDR 7456 15098, 22740, 30382, 38024, 45666, 53308, 60950 anti-influenza_CDR 7457 15099, 22741, 30383, 38025, 45667, 53309, 60951 anti-influenza_CDR 7458 15100, 22742, 30384, 38026, 45668, 53310, 60952 anti-influenza_CDR 7459 15101, 22743, 30385, 38027, 45669, 53311, 60953 anti-influenza_CDR 7460 15102, 22744, 30386, 38028, 45670, 53312, 60954 anti-influenza_CDR 7461 15103, 22745, 30387, 38029, 45671, 53313, 60955 anti-influenza_CDR 7462 15104, 22746, 30388, 38030, 45672, 53314, 60956 anti-influenza_CDR 7463 15105, 22747, 30389, 38031, 45673, 53315, 60957 anti-influenza_CDR 7464 15106, 22748, 30390, 38032, 45674, 53316, 60958 anti-influenza_CDR 7465 15107, 22749, 30391, 38033, 45675, 53317, 60959 anti-influenza_CDR 7466 15108, 22750, 30392, 38034, 45676, 53318, 60960 anti-influenza_CDR 7467 15109, 22751, 30393, 38035, 45677, 53319, 60961 anti-influenza_CDR 7468 15110, 22752, 30394, 38036, 45678, 53320, 60962 anti-influenza_CDR 7469 15111, 22753, 30395, 38037, 45679, 53321, 60963 anti-influenza_CDR 7470 15112, 22754, 30396, 38038, 45680, 53322, 60964 anti-influenza_CDR 7471 15113, 22755, 30397, 38039, 45681, 53323, 60965 anti-influenza_CDR 7472 15114, 22756, 30398, 38040, 45682, 53324, 60966 anti-influenza_CDR 7473 15115, 22757, 30399, 38041, 45683, 53325, 60967 anti-influenza_CDR 7474 15116, 22758, 30400, 38042, 45684, 53326, 60968 anti-influenza_CDR 7475 15117, 22759, 30401, 38043, 45685, 53327, 60969 anti-influenza_CDR 7476 15118, 22760, 30402, 38044, 45686, 53328, 60970 anti-influenza_CDR 7477 15119, 22761, 30403, 38045, 45687, 53329, 60971 anti-influenza_CDR 7478 15120, 22762, 30404, 38046, 45688, 53330, 60972 anti-influenza_CDR 7479 15121, 22763, 30405, 38047, 45689, 53331, 60973 anti-influenza_CDR 7480 15122, 22764, 30406, 38048, 45690, 53332, 60974 anti-influenza_CDR 7481 15123, 22765, 30407, 38049, 45691, 53333, 60975 anti-influenza_CDR 7482 15124, 22766, 30408, 38050, 45692, 53334, 60976 anti-influenza_CDR 7483 15125, 22767, 30409, 38051, 45693, 53335, 60977 anti-influenza_CDR 7484 15126, 22768, 30410, 38052, 45694, 53336, 60978 anti-influenza_CDR 7485 15127, 22769, 30411, 38053, 45695, 53337, 60979 anti-influenza_CDR 7486 15128, 22770, 30412, 38054, 45696, 53338, 60980 anti-influenza_CDR 7487 15129, 22771, 30413, 38055, 45697, 53339, 60981 anti-influenza_CDR 7488 15130, 22772, 30414, 38056, 45698, 53340, 60982 anti-influenza_CDR 7489 15131, 22773, 30415, 38057, 45699, 53341, 60983 anti-influenza_CDR 7490 15132, 22774, 30416, 38058, 45700, 53342, 60984 anti-influenza_CDR 7491 15133, 22775, 30417, 38059, 45701, 53343, 60985 anti-influenza_CDR 7492 15134, 22776, 30418, 38060, 45702, 53344, 60986 anti-influenza_CDR 7493 15135, 22777, 30419, 38061, 45703, 53345, 60987 anti-influenza_CDR 7494 15136, 22778, 30420, 38062, 45704, 53346, 60988 anti-influenza_CDR 7495 15137, 22779, 30421, 38063, 45705, 53347, 60989 anti-influenza_CDR 7496 15138, 22780, 30422, 38064, 45706, 53348, 60990 anti-influenza_CDR 7497 15139, 22781, 30423, 38065, 45707, 53349, 60991 anti-influenza_CDR 7498 15140, 22782, 30424, 38066, 45708, 53350, 60992 anti-influenza_CDR 7499 15141, 22783, 30425, 38067, 45709, 53351, 60993 anti-influenza_CDR 7500 15142, 22784, 30426, 38068, 45710, 53352, 60994 anti-influenza_CDR 7501 15143, 22785, 30427, 38069, 45711, 53353, 60995 anti-influenza_CDR 7502 15144, 22786, 30428, 38070, 45712, 53354, 60996 anti-influenza_CDR 7503 15145, 22787, 30429, 38071, 45713, 53355, 60997 anti-influenza_CDR 7504 15146, 22788, 30430, 38072, 45714, 53356, 60998 anti-influenza_CDR 7505 15147, 22789, 30431, 38073, 45715, 53357, 60999 anti-influenza_CDR 7506 15148, 22790, 30432, 38074, 45716, 53358, 61000 anti-influenza_CDR 7507 15149, 22791, 30433, 38075, 45717, 53359, 61001 anti-influenza_CDR 7508 15150, 22792, 30434, 38076, 45718, 53360, 61002 anti-influenza_CDR 7509 15151, 22793, 30435, 38077, 45719, 53361, 61003 anti-influenza_CDR 7510 15152, 22794, 30436, 38078, 45720, 53362, 61004 anti-influenza_CDR 7511 15153, 22795, 30437, 38079, 45721, 53363, 61005 anti-influenza_CDR 7512 15154, 22796, 30438, 38080, 45722, 53364, 61006 anti-influenza_CDR 7513 15155, 22797, 30439, 38081, 45723, 53365, 61007 anti-influenza_CDR 7514 15156, 22798, 30440, 38082, 45724, 53366, 61008 anti-influenza_CDR 7515 15157, 22799, 30441, 38083, 45725, 53367, 61009 anti-influenza_CDR 7516 15158, 22800, 30442, 38084, 45726, 53368, 61010 anti-influenza_CDR 7517 15159, 22801, 30443, 38085, 45727, 53369, 61011 anti-influenza_CDR 7518 15160, 22802, 30444, 38086, 45728, 53370, 61012 anti-influenza_CDR 7519 15161, 22803, 30445, 38087, 45729, 53371, 61013 anti-influenza_CDR 7520 15162, 22804, 30446, 38088, 45730, 53372, 61014 anti-influenza_CDR 7521 15163, 22805, 30447, 38089, 45731, 53373, 61015 anti-influenza_CDR 7522 15164, 22806, 30448, 38090, 45732, 53374, 61016 anti-influenza_CDR 7523 15165, 22807, 30449, 38091, 45733, 53375, 61017 anti-influenza_CDR 7524 15166, 22808, 30450, 38092, 45734, 53376, 61018 anti-0X40_HeavyChain_CDR1 7525 15167, 22809, 30451, 38093, 45735, 53377, 61019 anti-0X40_HeavyChain_CDR1 7526 15168, 22810, 30452, 38094, 45736, 53378, 61020 anti-0X40_HeavyChain_CDR1 7527 15169, 22811, 30453, 38095, 45737, 53379, 61021 anti-0X40_HeavyChain_CDR1 7528 15170, 22812, 30454, 38096, 45738, 53380, 61022 anti-0X40_HeavyChain_CDR1 7529 15171, 22813, 30455, 38097, 45739, 53381, 61023 anti-0X40_HeavyChain_CDR1 7530 15172, 22814, 30456, 38098, 45740, 53382, 61024 anti-0X40_LightChain_CDR2 7531 15173, 22815, 30457, 38099, 45741, 53383, 61025 anti-0X40_LightChain_CDR2 7532 15174, 22816, 30458, 38100, 45742, 53384, 61026 anti-0X40_LightChain_CDR2 7533 15175, 22817, 30459, 38101, 45743, 53385, 61027 anti-0X40_LightChain_CDR2 7534 15176, 22818, 30460, 38102, 45744, 53386, 61028 anti-0X40_LightChain_CDR3 7535 15177, 22819, 30461, 38103, 45745, 53387, 61029 anti-0X40_HeavyChain_CDR3 7536 15178, 22820, 30462, 38104, 45746, 53388, 61030 anti-0X40_HeavyChain_CDR3 7537 15179, 22821, 30463, 38105, 45747, 53389, 61031 anti-0X40_HeavyChain_CDR3 7538 15180, 22822, 30464, 38106, 45748, 53390, 61032 anti-0X40_LightChain_CDR3 7539 15181, 22823, 30465, 38107, 45749, 53391, 61033 anti-0X40_HeavyChain_CDR3 7540 15182, 22824, 30466, 38108, 45750, 53392, 61034 anti-0X40_LightChain_CDR3 7541 15183, 22825, 30467, 38109, 45751, 53393, 61035 anti-0X40_LightChain_CDR3 7542 15184, 22826, 30468, 38110, 45752, 53394, 61036 anti-0X40_LightChain_CDR3 7543 15185, 22827, 30469, 38111, 45753, 53395, 61037 anti-0X40_LightChain_CDR3 7544 15186, 22828, 30470, 38112, 45754, 53396, 61038 anti-0X40_LightChain_CDR3 7545 15187, 22829, 30471, 38113, 45755, 53397, 61039 anti-0X40_LightChain_CDR3 7546 15188, 22830, 30472, 38114, 45756, 53398, 61040 anti-0X40_LightChain_CDR3 7547 15189, 22831, 30473, 38115, 45757, 53399, 61041 anti-0X40_LightChain_CDR3 7548 15190, 22832, 30474, 38116, 45758, 53400, 61042 anti-0X40_LightChain_CDR3 7549 15191, 22833, 30475, 38117, 45759, 53401, 61043 anti-0X40_HeavyChain_CDR1 7550 15192, 22834, 30476, 38118, 45760, 53402, 61044 anti-0X40_HeavyChain_CDR3 7551 15193, 22835, 30477, 38119, 45761, 53403, 61045 anti-0X40_LightChain_CDR1 7552 15194, 22836, 30478, 38120, 45762, 53404, 61046 anti-0X40_LightChain_CDR1 7553 15195, 22837, 30479, 38121, 45763, 53405, 61047 anti-0X40_LightChain_CDR1 7554 15196, 22838, 30480, 38122, 45764, 53406, 61048 anti-0X40_HeavyChain_CDR3 7555 15197, 22839, 30481, 38123, 45765, 53407, 61049 anti-0X40_HeavyChain_CDR3 7556 15198, 22840, 30482, 38124, 45766, 53408, 61050 anti-0X40_HeavyChain_CDR3 7557 15199, 22841, 30483, 38125, 45767, 53409, 61051 anti-0X40_HeavyChain_CDR3 7558 15200, 22842, 30484, 38126, 45768, 53410, 61052 anti-0X40_HeavyChain_CDR2 7559 15201, 22843, 30485, 38127, 45769, 53411, 61053 anti-0X40_HeavyChain_CDR2 7560 15202, 22844, 30486, 38128, 45770, 53412, 61054 anti-0X40_HeavyChain_CDR2 7561 15203, 22845, 30487, 38129, 45771, 53413, 61055 anti-0X40_HeavyChain_CDR2 7562 15204, 22846, 30488, 38130, 45772, 53414, 61056 anti-0X40_HeavyChain_CDR2 7563 15205, 22847, 30489, 38131, 45773, 53415, 61057 anti-0X40_HeavyChain_CDR2 7564 15206, 22848, 30490, 38132, 45774, 53416, 61058 anti-0X40_HeavyChain_CDR2 7565 15207, 22849, 30491, 38133, 45775, 53417, 61059 anti-0X40_HeavyChain_CDR2 7566 15208, 22850, 30492, 38134, 45776, 53418, 61060 anti-0X40_HeavyChain_CDR2 7567 15209, 22851, 30493, 38135, 45777, 53419, 61061 anti-0X40_HeavyChain_CDR2 7568 15210, 22852, 30494, 38136, 45778, 53420, 61062 anti-0X40_HeavyChain_CDR2 7569 15211, 22853, 30495, 38137, 45779, 53421, 61063 anti-0X40_HeavyChain_CDR2 7570 15212, 22854, 30496, 38138, 45780, 53422, 61064

Accordingly, it is preferred that the CDR encoded by the at least one coding sequence comprises or consists of an amino acid sequence as set forth in any of SEQ ID NOs: 5601-7570. It is also preferred that the at least one coding sequence comprises or consists of a nucleic acid sequence as set forth in any of SEQ ID NOs: 13243-15212, 20885-22854, 28527-30496, 36169-38138, 43811-45780, 51453-53422, and 59095-61064.

The amino acid sequences of exemplary CDRs comprising less than 4 amino acids are shown below in Table 7.

TABLE 7 Amino acid sequences and corresponding SEQ ID NOs of exemplary CDRs comprising less than 4 amino acids Amino Acid Sequence SEQ ID NO AR 6478 AK 6479 SNN 6480 VAS 6481 ATY 6482 TAY 6483 DND 6484 HGT 6485 DVS 6486 DTD 6487 GAS 6488 KAS 6489 DDS 6490 AAS 6491 SAS 6492 LGS 6493 WAS 6494 EDS 6495 DDD 6496 TDN 6497 LAS 6498 DAS 6499 EVR 6500 DDR 6501 AAI 6502 RAS 6503

The nucleic acid (RNA) sequences of exemplary CDRs comprising less than 10 nucleotides are shown below in Table 8.

TABLE 8 RNA sequences and corresponding SEQ ID NOs of exemplary CDRs comprising less than 10 nucleotides RNA Sequence SEQ ID NO GCCCGC 14120 GCCAAG 14121 AGCAACAAC 14122 GUGGCCAGC 14123 GCCACCUAC 14124 ACCGCCUAC 14125 GACAACGAC 14126 CACGGCACC 14127 GACGUGAGC 14128 GACACCGAC 14129 GGCGCCAGC 14130 AAGGCCAGC 14131 GACGACAGC 14132 GCCGCCAGC 14133 AGCGCCUCC 14134 CUGGGCAGC 14135 UGGGCCAGC 14136 GAGGACAGC 14137 CAGGACGAC 14138 ACCGACAAC 14139 CUGGCCAGC 14140 GACGCCAGC 14141 GAGGUGCGC 14142 GACGACCGC 14143 GCCGCCAUC 14144 CGCGCCAGC 14145 GCCCGC 21762 GCCAAG 21763 UCCAACAAC 21764 GUCGCCUCC 21765 GCCACCUAC 21766 ACCGCCUAC 21767 GACAACGAC 21768 CACGGCACC 21769 GACGUCUCC 21770 GACACCGAC 21771 GGCGCCUCC 21772 AAGGCCUCC 21773 GACGACUCC 21774 GCCGCCUCC 21775 UCCGCCUCC 21776 CUCGGCUCC 21777 UGGGCCUCC 21778 GAGGACUCC 21779 CAGGACGAC 21780 ACCGACAAC 21781 CUCGCCUCC 21782 GACGCCUCC 21783 GAGGUCCGC 21784 GACGACCGC 21785 GCCGCCAUC 21786 CGCGCCUCC 21787 GCCAGA 29404 GCCAAG 29405 AGCAACAAU 29406 GUGGCCAGC 29407 GCCACCUAC 29408 ACCGCCUAC 29409 GACAACGAU 29410 CACGGCACC 29411 GACGUGAGC 29412 GACACCGAU 29413 GGCGCCAGC 29414 AAGGCCAGC 29415 GACGAUAGC 29416 GCCGCUAGC 29417 AGCGCCUCC 29418 CUGGGCAGC 29419 UGGGCCAGC 29420 GAGGACAGC 29421 CAGGACGAU 29422 ACCGACAAC 29423 CUGGCCAGC 29424 GACGCCAGC 29425 GAGGUGAGA 29426 GACGAUAGA 29427 GCCGCUAUC 29428 AGAGCCAGC 29429 GCCAGA 37046 GCCAAG 37047 AGCAACAAC 37048 GUGGCCAGC 37049 GCCACCUAC 37050 ACCGCCUAC 37051 GACAACGAC 37052 CACGGCACC 37053 GACGUGAGC 37054 GACACCGAC 37055 GGCGCCAGC 37056 AAGGCCAGC 37057 GACGACAGC 37058 GCCGCCAGC 37059 AGCGCCAGC 37060 CUGGGCAGC 37061 UGGGCCAGC 37062 GAGGACAGC 37063 CAGGACGAC 37064 ACCGACAAC 37065 CUGGCCAGC 37066 GACGCCAGC 37067 GAGGUGAGA 37068 GACGACAGA 37069 GCCGCCAUC 37070 AGAGCCAGC 37071 GCCAGA 44688 GCCAAG 44689 AGCAACAAU 44690 GUGGCCAGC 44691 GCCACCUAC 44692 ACCGCCUAC 44693 GACAACGAU 44694 CACGGCACC 44695 GACGUGAGC 44696 GACACCGAU 44697 GGCGCCAGC 44698 AAGGCCAGC 44699 GACGAUAGC 44700 GCCGCUAGC 44701 AGCGCCUCC 44702 CUGGGCAGC 44703 UGGGCCAGC 44704 GAGGACAGC 44705 CAGGACGAU 44706 ACCGACAAC 44707 CUGGCCAGC 44708 GACGCCAGC 44709 GAGGUGAGA 44710 GACGAUAGA 44711 GCCGCUAUC 44712 AGAGCCAGC 44713 GCGCGA 52330 GCCAAG 52331 AGCAAUAAC 52332 GUCGCUAGU 52333 GCCACAUAU 52334 ACCGCCUAC 52335 GAUAACGAU 52336 CACGGCACC 52337 GACGUAAGU 52338 GAUACAGAU 52339 GGCGCGAGU 52340 AAAGCCAGC 52341 GACGACAGU 52342 GCCGCUUCA 52343 AGCGCGAGC 52344 CUAGGCAGC 52345 UGGGCAAGU 52346 GAGGACAGU 52347 CAAGACGAC 52348 ACCGACAAC 52349 CUCGCUAGC 52350 GACGCCAGU 52351 GAGGUGAGA 52352 GACGAUAGA 52353 GCGGCUAUA 52354 CGCGCGAGC 52355 GCGCGG 59972 GCGAAG 59973 UCCAACAAC 59974 GUCGCCAGU 59975 GCCACCUAU 59976 ACCGCCUAC 59977 GAUAACGAU 59978 CACGGCACC 59979 GACGUGAGU 59980 GAUACCGAU 59981 GGCGCGAGU 59982 AAAGCGAGC 59983 GACGACAGU 59984 GCCGCCUCA 59985 AGCGCAAGU 59986 CUCGGCAGC 59987 UGGGCGAGU 59988 GAGGACAGU 59989 CAAGACGAC 59990 ACCGACAAC 59991 CUCGCCAGC 59992 GACGCGAGU 59993 GAGGUCAGG 59994 GACGACAGA 59995 GCGGCCAUA 59996 CGCGCGAGC 59997

Preferably, the RNA according to the present invention comprises coding sequences encoding at least two CDRs of an antibody, more preferably at least three CDRs of an antibody, even more preferably at least four CDRs of an antibody, still more preferably at least five CDRs of an antibody, and most preferably six CDRs of an antibody.

It is also preferred that the at least one coding sequence of the RNA according to the present invention encodes a constant region of an antibody or a fragment or variant of constant region of an antibody. Typically, the constant region is identical in all antibodies of the same isotype, but differs in antibodies of different isotypes. Heavy chains γ, α and δ have a constant region composed of three tandem (in a line) immunoglobulin domains, and a hinge region for added flexibility; heavy chains μ and ε have a constant region composed of four immunoglobulin domains.

Preferably, the at least one coding sequence of the RNA according to the present invention encodes a heavy chain constant region of an antibody or a fragment or variant of heavy chain constant region of an antibody. It is also preferred that the at least one coding sequence encodes a light chain constant region of an antibody or a fragment or variant of light chain constant region of an antibody.

It is also preferred that the constant region encoded by the at least one coding sequence comprises or consists of an amino acid sequence as described in Table 9 below (referred to as “protein SEQ ID NO”). Particularly preferably, the at least one coding sequence comprises or consists of a nucleic acid sequence (RNA sequence) as described in Table 9 below (referred to as “RNA SEQ ID NO”).

TABLE 9 Overview over the SEQ ID NOs of the amino acid sequences of preferred exemplary constant regions and of the respective encoding RNA sequences. Name Protein SEQ ID NO: RNA SEQ ID NO: Ig_LightChain_kappa_constant_domain 7571 15213, 22855, 30497, 38139, 45781, 53423, 61065 Ig_LightChain_kappa_constant_domain 7572 15214, 22856, 30498, 38140, 45782, 53424, 61066 Ig_LightChain_lambda_constant_domain 7573 15215, 22857, 30499, 38141, 45783, 53425, 61067 Ig_LightChain_lambda_constant_domain 7574 15216, 22858, 30500, 38142, 45784, 53426, 61068 Ig_LightChain_lambda_constant_domain 7575 15217, 22859, 30501, 38143, 45785, 53427, 61069 Ig_LightChain_lambda_constant_domain 7576 15218, 22860, 30502, 38144, 45786, 53428, 61070 IgG1_HeavyChain_CH1_constant_domain 7577 15219, 22861, 30503, 38145, 45787, 53429, 61071 IgG1_HeavyChain_CH1_constant_domain 7578 15220, 22862, 30504, 38146, 45788, 53430, 61072 IgG1_HeavyChain_CH1_constant_domain 7579 15221, 22863, 30505, 38147, 45789, 53431, 61073 IgG1_HeavyChain_CH1_constant_domain 7580 15222, 22864, 30506, 38148, 45790, 53432, 61074 IgG1_HeavyChain_CH1_constant_domain 7581 15223, 22865, 30507, 38149, 45791, 53433, 61075 IgG1_HeavyChain_CH1_constant_domain 7582 15224, 22866, 30508, 38150, 45792, 53434, 61076 IgG1_HeavyChain_CH1_constant_domain 7583 15225, 22867, 30509, 38151, 45793, 53435, 61077 IgG1_HeavyChain_CH1_constant_domain 7584 15226, 22868, 30510, 38152, 45794, 53436, 61078 IgG1_HeavyChain_CH1_constant_domain 7585 15227, 22869, 30511, 38153, 45795, 53437, 61079 IgG1_HeavyChain_CH1_constant_domain 7586 15228, 22870, 30512, 38154, 45796, 53438, 61080 IgG1_HeavyChain_CH1_constant_domain 7587 15229, 22871, 30513, 38155, 45797, 53439, 61081 IgG1_HeavyChain_CH1_constant_domain 7588 15230, 22872, 30514, 38156, 45798, 53440, 61082 IgG1_HeavyChain_CH1_constant_domain 7589 15231, 22873, 30515, 38157, 45799, 53441, 61083 IgG1_HeavyChain_CH1_constant_domain 7590 15232, 22874, 30516, 38158, 45800, 53442, 61084 IgG1_HeavyChain_CH1_constant_domain 7591 15233, 22875, 30517, 38159, 45801, 53443, 61085 IgG1_HeavyChain_CH1_constant_domain 7592 15234, 22876, 30518, 38160, 45802, 53444, 61086 IgG1_HeavyChain_CH2_constant_domain 7593 15235, 22877, 30519, 38161, 45803, 53445, 61087 IgG1_HeavyChain_CH2_constant_domain 7594 15236, 22878, 30520, 38162, 45804, 53446, 61088 IgG1_HeavyChain_CH2_constant_domain 7595 15237, 22879, 30521, 38163, 45805, 53447, 61089 IgG1_HeavyChain_CH2_constant_domain 7596 15238, 22880, 30522, 38164, 45806, 53448, 61090 IgG1_HeavyChain_CH2_constant_domain 7597 15239, 22881, 30523, 38165, 45807, 53449, 61091 IgG1_HeavyChain_CH2_constant_domain 7598 15240, 22882, 30524, 38166, 45808, 53450, 61092 IgG1_HeavyChain_CH2_constant_domain 7599 15241, 22883, 30525, 38167, 45809, 53451, 61093 IgG1_HeavyChain_CH2_constant_domain 7600 15242, 22884, 30526, 38168, 45810, 53452, 61094 IgG1_HeavyChain_CH2_constant_domain 7601 15243, 22885, 30527, 38169, 45811, 53453, 61095 IgG1_HeavyChain_CH2_constant_domain 7602 15244, 22886, 30528, 38170, 45812, 53454, 61096 IgG1_HeavyChain_CH2_constant_domain 7603 15245, 22887, 30529, 38171, 45813, 53455, 61097 IgG1_HeavyChain_CH2_constant_domain 7604 15246, 22888, 30530, 38172, 45814, 53456, 61098 IgG1_HeavyChain_CH2_constant_domain 7605 15247, 22889, 30531, 38173, 45815, 53457, 61099 IgG1_HeavyChain_CH2_constant_domain 7606 15248, 22890, 30532, 38174, 45816, 53458, 61100 IgG1_HeavyChain_CH2_constant_domain 7607 15249, 22891, 30533, 38175, 45817, 53459, 61101 IgG1_HeavyChain_CH2_constant_domain 7608 15250, 22892, 30534, 38176, 45818, 53460, 61102 IgG1_HeavyChain_CH2_constant_domain 7609 15251, 22893, 30535, 38177, 45819, 53461, 61103 IgG1_HeavyChain_CH2_constant_domain 7610 15252, 22894, 30536, 38178, 45820, 53462, 61104 IgG1_HeavyChain_CH2_constant_domain 7611 15253, 22895, 30537, 38179, 45821, 53463, 61105 IgG1_HeavyChain_CH2_constant_domain 7612 15254, 22896, 30538, 38180, 45822, 53464, 61106 IgG1_HeavyChain_CH2_constant_domain 7613 15255, 22897, 30539, 38181, 45823, 53465, 61107 IgG1_HeavyChain_CH2_constant_domain 7614 15256, 22898, 30540, 38182, 45824, 53466, 61108 IgG1_HeavyChain_CH2_constant_domain 7615 15257, 22899, 30541, 38183, 45825, 53467, 61109 IgG1_HeavyChain_CH2_constant_domain 7616 15258, 22900, 30542, 38184, 45826, 53468, 61110 IgG1_HeavyChain_CH2_constant_domain 7617 15259, 22901, 30543, 38185, 45827, 53469, 61111 IgG1_HeavyChain_CH2_constant_domain 7618 15260, 22902, 30544, 38186, 45828, 53470, 61112 IgG1_HeavyChain_CH2_constant_domain 7619 15261, 22903, 30545, 38187, 45829, 53471, 61113 IgG1_HeavyChain_CH2_constant_domain 7620 15262, 22904, 30546, 38188, 45830, 53472, 61114 IgG1_HeavyChain_CH2_constant_domain 7621 15263, 22905, 30547, 38189, 45831, 53473, 61115 IgG1_HeavyChain_CH2_constant_domain 7622 15264, 22909, 30548, 38190, 45832, 53474, 61116 IgG1_HeavyChain_CH2_constant_domain 7623 15265, 22907, 30549, 38191, 45833, 53475, 61117 IgG1_HeavyChain_CH2_constant_domain 7624 15266, 22908, 30550, 38192, 45834, 53476, 61118 IgG1_HeavyChain_CH3_constant_domain 7625 15267, 22909, 30551, 38193, 45835, 53477, 61119 IgG1_HeavyChain_CH3_constant_domain 7626 15268, 22910, 30552, 38194, 45836, 53478, 61120 IgG1_HeavyChain_CH3_constant_domain 7627 15269, 22911, 30553, 38195, 45837, 53479, 61121 IgG1_HeavyChain_CH3_constant_domain 7628 15270, 22912, 30554, 38196, 45838, 53480, 61122 IgG2_HeavyChain_CH1_constant_domain 7629 15271, 22913, 30555, 38197, 45839, 53481, 61123 IgG2_HeavyChain_CH1_constant_domain 7630 15272, 22914, 30556, 38198, 45840, 53482, 61124 IgG2_HeavyChain_CH2_constant_domain 7631 15273, 22915, 30557, 38199, 45841, 53483, 61125 IgG2_HeavyChain_CH2_constant_domain 7632 15274, 22916, 30558, 38200, 45842, 53484, 61126 IgG2_HeavyChain_CH2_constant_domain 7633 15275, 22917, 30559, 38201, 45843, 53485, 61127 IgG2_HeavyChain_CH2_constant_domain 7634 15276, 22918, 30560, 38202, 45844, 53486, 61128 IgG2_HeavyChain_CH2_constant_domain 7635 15277, 22919, 30561, 38203, 45845, 53487, 61129 IgG2_HeavyChain_CH2_constant_domain 7636 15278, 22920, 30562, 38204, 45846, 53488, 61130 IgG2_HeavyChain_CH2_constant_domain 7637 15279, 22921, 30563, 38205, 45847, 53489, 61131 IgG2_HeavyChain_CH2_constant_domain 7638 15280, 22922, 30564, 38206, 45848, 53490, 61132 IgG2_HeavyChain_CH3_constant_domain 7639 15281, 22923, 30565, 38207, 45849, 53491, 61133 IgG4_HeavyChain_CH1_constant_domain 7640 15282, 22924, 30565, 38208, 45850, 53492, 61134 IgG4_HeavyChain_CH2_constant_domain 7641 15283, 22925, 30567, 38209, 45851, 53493, 61135 IgG4_HeavyChain_CH3_constant_domain 7642 15284, 22926, 30568, 38210, 45852, 53494, 61136

Accordingly, it is preferred that the constant region or the fragment or variant thereof encoded by the at least one coding sequence comprises or consists of an amino acid sequence as set forth in any of SEQ ID NOs: 7571-7642. It is also preferred that the at least one coding sequence comprises or consists of a nucleic acid sequence as set forth in any of SEQ ID NOs: 15213-15284, 22855-22926, 30497-30568, 38139-38210, 45781-45852, 53423-53494, and 61065-61136.

Preferably, the RNA according to the present invention comprises (i) a coding sequence encoding a heavy chain variable region, or a fragment or variant thereof, and a heavy chain constant region, or a fragment or variant thereof; and/or (ii) a coding sequence encoding a light chain variable region, or a fragment or variant thereof, and a light chain constant region, or a fragment or variant thereof.

Preferably, the antibody or the fragment thereof, which is encoded by the RNA according to the present invention, is chosen from monoclonal and polyclonal antibodies or fragments thereof, chimeric antibodies or fragments thereof, human antibodies or fragments thereof, humanized antibodies or fragments thereof, and intrabodies or fragments thereof.

It is also preferred that the antibody or the fragment thereof, which is encoded by the RNA according to the present invention, is a monospecific or a multispecific antibody or antibody fragment. Preferably, the antibody or the fragment thereof, which is encoded by the RNA according to the present invention, is a bispecific or a trispecific antibody or antibody fragment.

As used herein, the term “multispecific” refers to the ability to bind to at least two different epitopes, e.g. on different antigens, whereas a monospecific antibody can only bind to one type of antigens (a monospecific antibody comprising one or more binding site for one and the same epitope). Thus, terms like “monospecific”, “bispecific”, trispecific”, “tetraspecific” etc. refer to the number of different epitopes to which the antibody can bind to. For example, conventional monospecific IgG-type antibodies have two identical epitope binding sites (paratopes) and can, thus, only bind to identical epitopes (but not to different epitopes). A multispecific antibody, in contrast, has at least two different types of paratopes and can, thus, bind to at least two different epitopes. Moreover, a single “specificity” may refer to one, two, three or more identical paratopes in a single antibody (the actual number of paratopes in one single antibody molecule is referred to as “valency”). For example, a single native IgG antibody is monospecific and bivalent, since it has two identical paratopes. Accordingly, a multispecific antibody comprises at least two (different) paratopes. Thus, the term “multispecific antibodies” refers to antibodies having more than one paratope and the ability to bind to two or more different epitopes. The term “multispecific antibodies” comprises in particular bispecific antibodies, but typically also antibodies, which bind in particular to three or more different epitopes, i.e. antibodies with three or more paratopes.

Accordingly, the present invention does not only provide RNA molecules encoding monospecific antibodies or fragments or variants thereof, but RNA molecules which code for multispecific, such as bispecific or trispecific, antibodies or fragments or variants thereof can also be provided in the context of the present invention. Bispecific antibodies in the context of the present invention are preferably antibodies which can act as adaptors between an effector and a corresponding target, e.g. for recruiting effector molecules (e.g. toxins, active compounds (drugs), cytokines etc.), targeting of effector cells (e.g. CTL, NK cells, macrophages, granulocytes etc. (see, for example, review by Kontermann R. E., Acta Pharmacol. Sin, 2005, 26(1): 1-9). In this context, bispecific antibodies are in principle built up such as is described here in general for antibodies, these bispecific antibodies e.g. recognizing two different antigens, immunogens or epitopes, or active compounds, cells, or other molecules (or structures) as mentioned above, i.e. the antigen-binding regions of the antibody are specific for two different molecules (or structures). The various antigens, immunogens or epitopes etc., for example, can thus be brought spatially close. Furthermore, by the binding e.g. of a binding domain or other specificities, the function of the antibody can be extended specifically, e.g. of a binding protein, an immunotoxin etc. Such bispecific antibodies can also be single-chain antibodies (e.g. scFv fragments etc.). Bispecific antibodies can be used, for example, to bring two reaction partners, e.g. two cells, two proteins, a protein and the substrate thereof etc., spatially close in order to promote an interaction between these (e.g. protein-protein interactions, substrate conversions, modifications etc.). Bispecific antibodies are preferably used above all to bring effector cells (such as, for example, T cells, NK cells, macrophages etc.) and target cells (e.g. tumour cells, infected cells etc.) spatially close. Examples of bispecific antibodies can include, without being limited thereto, e.g. those antibodies or antibody fragments which bind on the one hand a surface factor as described here, and on the other hand an antigen as described here, preferably a tumour antigen as described here. This includes e.g. CD28 and a tumour antigen (Grosse-Hovest L. et al., 2003, Eur. Immunol. 33(5); 1334-40, (A recombinant bispecific single-chain antibody induces targeted, supra-agonistic CD28-stimulation and tumor cell killing)), CD19 and CD3 (CD19 tumour antigen of B cell lymphoma) etc.

Preferably, the antibody fragment encoded by the RNA according to the present invention is selected from the group consisting of Nanobody; Nanobody-HAS; BiTE; Diabody; DART; TandAb; scDiabody; sc-Diabody-CH3; Diabody-CH3; Triple Body; Miniantibody; Minibody; TriBi minibody; scFv-CH3 KIH; Fab-scFv; scFv-CH-CL-scFv; F(ab′)2; F(ab′)2-scFv2; scFv-KIH; Fab-scFv-Fc; Tetravalent HCAb; scDiabody-Fc; Diabody-Fc; Tandem scFv-Fc; Fab; Fab′; Fc; Facb; pFc′; Fd; Fv or scFv antibody fragment. These bispecific antibody formats are shown and described for example in Spiess C., Zhai Q. and Carter P. J. (2015) Molecular Immunology 67: 95-106, in particular FIG. 1 and corresponding description, e.g. p. 95-101.

Preferably, the antibody or the fragment thereof, which is encoded by the RNA according to the present invention, comprises a binding site for an Fc receptor, in particular an Fc moiety. As used herein, the term “Fc moiety” refers to a sequence derived from the portion of an immunoglobulin heavy chain beginning in the hinge region just upstream of the papain cleavage site and ending at the C-terminus of the immunoglobulin heavy chain. Preferably, the “Fc moiety” comprises a binding site for an Fc receptor. However, it is also preferred that an Fc moiety may mediate a functionality different from binding to an Fc receptor, for example binding to a protein of the complement system. Accordingly, an “Fc moiety” may be a complete Fc region or a part (e.g., a domain) thereof. Preferably, the “Fc moiety” mediates the full functionality of a complete Fc region, e.g. including Fc receptor binding and, optionally, binding to a protein from the complement system. Thus, the antibody as used according to the present invention preferably comprises a complete Fc region, whereby a complete Fc region comprises at least a hinge domain, a CH2 domain, and a CH3 domain. The Fc moiety may also comprise one or more amino acid insertions, deletions, or substitutions relative to a naturally-occurring Fc region. For example, at least one of a hinge domain, CH2 domain or CH3 domain (or portion thereof) may be deleted. For example, an Fc moiety may comprise or consist of: (i) hinge domain (or portion thereof) fused to a CH2 domain (or portion thereof), (ii) a hinge domain (or portion thereof) fused to a CH3 domain (or portion thereof), (iii) a CH2 domain (or portion thereof) fused to a CH3 domain (or portion thereof), (iv) a hinge domain (or portion thereof), (v) a CH2 domain (or portion thereof), or (vi) a CH3 domain or portion thereof.

The antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be of any antibody format. In particular, antibodies preferably encompass “whole” antibodies, such as whole IgG- or IgG-like molecules, while antigen binding fragments in the context of the present invention preferably refer to small recombinant formats, such as bispecific T-cell engagers (BiTes), tandem single chain variable fragment molecules (taFvs), diabodies (Dbs), single chain diabodies (scDbs) and various other derivatives of these (cf. bispecific antibody formats as described by Byrne H. et al. (2013) Trends Biotech, 31 (11): 621-632 with FIG. 2 showing various bispecific antibody formats; Weidle U. H. et al. (2013) Cancer Genomics and Proteomics 10: 1-18, in particular FIG. 1 showing various bispecific antibody formats; and Chan, A. C. and Carter, P. J. (2010) Nat Rev Immu 10: 301-316 with FIG. 3 showing various bispecific antibody formats). Examples of bispecific antibody formats include, but are not limited to, quadroma, chemically coupled Fab (fragment antigen binding), and BiTE® (bispecific T cell engager). In one embodiment of the present invention the antibody used is preferably a BiTE® (bispecific T cell engager).

Thus, the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be selected from the group comprising hybrid hybridoma (quadroma); Multispecific anticalin platform (Pieris); Diabodies; Single chain diabodies; Tandem single chain Fv fragments; TandAbs, Trispecific Abs (Affimed) (105-110 kDa); Darts (dual affinity retargeting; Macrogenics); Bispecific Xmabs (Xencor); Bispecific T cell engagers (Bites; Amgen; 55kDa); Triplebodies; Tribody=Fab-scFv Fusion Protein (CreativeBiolabs) multifunctional recombinant antibody derivates (110 kDa); Duobody platform (Genmab); Dock and lock platform; Knob into hole (KIH) platform; Humanized bispecific IgG antibody (REGN1979) (Regeneron); Mabe bispecific antibodies (F-Star); DVD-Ig=dual variable domain immunoglobulin (Abbvie); kappa-lambda bodies; TBTI=tetravalent bispecific tandem Ig; and CrossMab.

The antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be selected from bispecific IgG-like antibodies (BsIgG) comprising CrossMab; DAF (two-in-one); DAF (four-in-one); DutaMab; DT-IgG; Knobs-in-holes common LC; Knobs-in-holes assembly; Charge pair; Fab-arm exchange; SEEDbody; Triomab; LUZ-Y; Fcab; κλ-body; and Orthogonal Fab. These bispecific antibody formats are shown and described for example in Spiess C., Zhai Q. and Carter P. J. (2015) Molecular Immunology 67: 95-106, in particular FIG. 1 and corresponding description, e.g. p. 95-101.

Preferably, the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be selected from IgG-appended antibodies with an additional antigen-binding moiety comprising DVD-IgG; IgG(H)-scFv; scFv-(H)IgG; IgG(L)-scFv; scFV-(L)IgG; IgG(L,H)-Fv; IgG(H)-V; V(H)-IgG; IgG(L)-V; V(L)-IgG; KIH IgG-scFab; 2scFv-IgG; IgG-2scFv; scFv4-Ig; scFv4-Ig; Zybody; and DVI-IgG (four-in-one). These bispecific antibody formats are shown and described for example in Spiess C., Zhai Q. and Carter P. J. (2015) Molecular Immunology 67: 95-106, in particular FIG. 1 and corresponding description, e.g. p. 95-101.

Preferably, the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be selected from bispecific antibody fragments comprising Nanobody; Nanobody-HAS; BiTE; Diabody; DART; TandAb; scDiabody; sc-Diabody-CH3; Diabody-CH3; Triple Body; Miniantibody; Minibody; TriBi minibody; scFv-CH3 KIH; Fab-scFv; scFv-CH-CL-scFv; F(ab′)2; F(ab′)2-scFv2; scFv-KIH; Fab-scFv-Fc; Tetravalent HCAb; scDiabody-Fc; Diabody-Fc; Tandem scFv-Fc; and Intrabody. These bispecific antibody formats are shown and described for example in Spiess C., Zhai Q. and Carter P. J. (2015) Molecular Immunology 67: 95-106, in particular FIG. 1 and corresponding description, e.g. p. 95-101.

Preferably, the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be selected from bispecific fusion proteins comprising Dock and Lock; ImmTAC; HSAbody; scDiabody-HAS; and Tandem scFv-Toxin. These bispecific antibody formats are shown and described for example in Spiess C., Zhai Q. and Carter P. J. (2015) Molecular Immunology 67: 95-106, in particular FIG. 1 and corresponding description, e.g. p. 95-101.

In particular, the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, may be selected from bispecific antibody conjugates comprising IgG-IgG; Cov-X-Body; and scFv1-PEG-scFv2. These bispecific antibody formats are shown and described for example in Spiess C., Zhai Q. and Carter P. J. (2015) Molecular Immunology 67: 95-106, in particular FIG. 1 and corresponding description, e.g. p. 95-101.

Depending on the amino acid sequence of the constant region of their heavy chains, antibodies or immunoglobulins are divided in the classes: IgA, IgD, IgE, IgG and IgM, and several of these may be further divided into subclasses, e.g. IgG1, IgG2, IgG3, and IgG4, IgA1 and IgA2. The heavy chain constant regions that correspond to the different classes of immunoglobulins are called α, ε, γ, and μ, respectively. The antibodies according to the invention are preferably of IgG type. It is also preferred that the antibody, which is encoded by the RNA according to the present invention, has an IgG-like format, which includes, in addition to IgG type antibodies, recombinant antibodies based on IgG, such as the IgG-appended antibodies and the bispecific IgG-like antibodies described above.

Preferably, the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, is a single-chain antibody or a single-chain antibody fragment. It is also preferred that the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, is a multiple-chain antibody or a multiple-chain antibody fragment. The term “chain”, as used herein, in particular in the context of a single-chain and a multiple-chain antibody, typically refers to a chain of amino acids connected by a peptide bond, such that a “chain” typically refers to a single peptide or protein. Accordingly, in particular two peptides/proteins connected via disulfide bridges (also referred to as “SS-bonds”) do not form a single chain. For example, an sc-Fv antibody, wherein the variable regions are connected via a peptide linker is referred to—in the context of the present invention—as a single-chain antibody, whereas it were referred to as a multiple-chain antibody, if the variable regions are connected via a disulfide bridge.

It is also preferred that the antibody, or the antigen binding fragment thereof, which is encoded by the RNA according to the present invention, specifically recognizes and binds to tumour-specific surface antigens chosen from (TSSA), 5T4, α5β1-integrin, 707-AP, AFP, ART-4, B7H4, BAGE, β-catenin/m, Bcr-abl, MN/C IX-antigen, CA125, CAMEL, CAP-1, CASP-8, β-catenin/m, CD4, CD19, CD20, CD22, CD25, CDC27/m, CD 30, CD33, CD52, CD56, CD80, CDK4/m, CEA, CT, Cyp-B, DAM, EGFR, ErbB3, ELF2M, EMMPRIN, EpCam, ETV6-AML1, G250, GAGE, GnT-V, Gp100, HAGE, HER-2/neu, HLA-A*0201-R170I, HPV-E7, HSP70-2M, HAST-2, hTERT (or hTRT), iCE, IGF-1R, IL-2R, IL-5, KIAA0205, LAGE, LDLR/FUT, MAGE, MART-1/Melan-A, MART-2/Ski, MC1R, myosin/m, MUC1, MUM-1, -2, -3, NA88-A, PAP, proteinase-3, p190 minor bcr-abl, Pml/RARα, PRAME, PSA, PSM, PSMA, RAGE, RU1 or RU2, SAGE, SART-1 or SART-3, survivin, TEL/AML1, TGFβ, TPI/m, TRP-1, TRP-2, TRP-2/INT2, VEGF and WT1, NY-Eso-1 and NY-Eso-B, as described above.

Preferably, the at least one coding sequence of the RNA according to the present invention encodes an antibody selected from the group consisting of AAB-003; Abagovomab; Abciximab; Abituzumab; Abrilumab; Actoxumab; Adalimumab; Aducanumab; Afasevikumab; Aflibercept; Afutuzuab; Afutuzumab; Alacizumab_pegol; Alemtuzumab; Alirocumab; ALX-0061; Amatuximab; Anetumab_ravtansine; Anifrolumab; Anrukinzumab; Apolizumab; Apomab; Aquaporumab; Arcitumomab_99tc; Ascrinvacumab; Aselizuab; Atezolizumab; Atinumab; Atlizuab; Aurograb; Avelumab; Bapineuzumab; Basiliximab; Bavituximab; Begelomab; Benralizumab; Betalutin; Bevacituzuab; Bevacizumab_154-aspartic_acid; Bevacizumab_154-substitution; Bevacizumab_180-serine; Bevacizumab_180-substitution; Bevacizumab_beta; Bevacizumab; Bevacizumab-rhuMAb-VEGF; Bezlotoxumab; Bimagrumab; Bimekizumab; Bleselumab; Blinatumomab; Blinatumumab; Blontuvetmab; Blosozumab; Bococizumab; Brentuximab_vedotin; Briakinumab; Brodalumab; Brolucizumab; Brontictuzumab; BTT-1023; Burosumab; Canakinumab; Cantuzumab; Cantuzumab_mertansine; Cantuzumab_ravtansine; Caplacizumab; Carlumab; Cergutuzumab_amunaleukin; Certolizumab_pegol; Cetuximab; Citatuzumab_bogatox; Cixutumumab; Clazakizumab; Clivatuzumab_tetraxetan; Codrituzumab; Coltuximab_ravtansine; Conatumumab_CV; Conatumumab; Concizumab; Crenezumab; Crotedumab; Dacetuzumab; Dacliximab; Daclizumab; Dalotuzumab; Dapirolizumab_pegol; Daratumumab; Dectrekumab; Demcizumab; Denintuzumab_mafodotin; Denosumab; Depatuxizumab; Depatuxizumab_mafodotin; Dinutuximab_beta; Dinutuximab; Diridavumab; Domagrozumab; Drozituab; Drozitumab; Duligotumab; Duligotuzumab; Dupilumab; Durvalumab; Dusigitumab; Ecromeximab; Eculizumab; Efalizumab; Efungumab; Eldelumab; Elgemtumab; Elotuzumab; Emactuzumab; Emibetuzumab; Emicizumab; Enavatuzumab; Enfortumab; Enfortumab_vedotin; Enoblituzumab; Enokizumab; Enoticumab; Ensituximab; Entolimod; Epratuzumab; Eptacog_beta; Erlizuab; Etaracizumab; Etrolizuab; Etrolizumab; Evinacumab; Evolocumab; Exbivirumab; Farletuzumab; Fasinumab; Fezakinumab; FG-3019; Fibatuzumab; Ficlatuzumab; Figitumumab; Firivumab; Flanvotumab; Fletikumab; Fontolizumab; Foralumab; Foravirumab; Fresolimumab; Fulranumab; Futuximab; Galcanezumab; Galiximab; Ganitumab; Gantenerumab; Gemtuzumab; Gemtuzumab_ozogamicin; Gevokizumab; Girentuximab; Glembatumumab; Goilixiab; Guselkumab; HuMab-001; HuMab-005; HuMab-006; HuMab-019; HuMab-021; HuMab-025; HuMab-027; HuMab-032; HuMab-033; HuMab-035; HuMab-036; HuMab-041; HuMab-044; HuMab-049; HuMab-050; HuMab-054; HuMab-055; HuMab-059; HuMab-060; HuMab-067; HuMab-072; HuMab-084; HuMab-091; HuMab-093; HuMab-098; HuMab-100; HuMab-106; HuMab_10F8; HuMab-111; HuMab-123; HuMab-124; HuMab-125; HuMab-127; HuMab-129; HuMab-132; HuMab-143; HuMab-150; HuMab-152; HuMab-153; HuMab-159; HuMab-160; HuMab-162; HuMab-163; HuMab-166; HuMab-167; HuMab-169; HuMab-7D8; huMAb-anti-MSP10.1; huMAb-anti-MSP10.2; HUMAB-Clone_18; HUMAB-Clone_22; HuMab-L612; HuMab_LC5002-002; HuMab_LC5002-003; HuMab_LC5002-005; HuMab_LC5002-007; HuMab_LC5002-018; Ibalizumab; Ibritumomab_tiuxetan; Icrucumab; Idarucizumab; Igatuzuab; IGF-IR_HUMAB-1A; IGF-IR_HUMAB-23; IGF-IR_HUMAB-8; ImAb1; Imalumab; Imgatuzumab; Inclacumab; Indatuximab_ravtansine; Indusatumab_vedotin; Inebilizumab; Insulin_peglispro; Interferon_beta-1b; Intetumumab; Iodine_(124I)_Girentuximab; Iodine_(131I)_Derlotuxiab_biotin; lodine_(131I)_Derlotuximab_biotin; Ipilimumab; Iratumumab; Isatuximab; Itolizumab; Ixekizumab; Labetuzumab_govitecan; Lambrolizumab; Lampalizumab; Lanadelumab; Landogrozumab; Laprituximab_emtansine; Lealesoab; Lebrikizumab; Lenercept_chain1; Lenzilumab; Lerdelimumab; Lexatumumab; Libivirumab; Lifastuzumab; Lifastuzumab_vedotin; Ligelizumab; Lilotomab; Lintuzumab; Lirilumab; Lodelcizumab; Lokivetmab; Lorvotuzumab_mertansine; Lpathomab; Lucatumumab; Lulizumab_pegol; Lumiliximab; Lumretuzumab; Lutetium_(177Lu)_lilotomab_satetraxetan; Margetuximab; Marzeptacog_alfa; Matuzumab; Mavrilimumab; MDX-1303; Mepolizumab; Metelimumab; Milatuzumab; Mirvetuximab; Modotuximab; Mogamulizumab; Monalizumab; Motavizumab; Moxetumomab_pasudotox; Muromonab-CD3; Namilumab; Naptumomab_estafenatox; Narnatumab; Natalizumab; Navicixizumab; Navivumab; Ndimab-varB; Necitumumab; Neliximab; Nemolizumab; Nesvacumab; Neuradiab; Nimotuzumab; Nivolumab; Obiltoxaximab; Obinutuzumab; Ocaratuzumab; Ocrelizumab; Ofatumumab; Olaratumab; Olizuab; Olokizumab; Omalizumab; Onartuzumab; Ontuxizumab; Opicinumab; Oportuzumab_monatox; Oreptacog_alfa; Orticumab; Otelixizumab; Otlertuzumab; Oxelumab; Ozanezumab; Ozoralizumab; Palivizumab; Pamrevlumab; Panitumumab; Pankoab; PankoMab; Panobacumab; Parsatuzumab; Pascolizumab; Pasotuxizumab; Pateclizumab; Patritumab; Pembrolizumab; Perakizumab; Pertuzuab; Pertuzumab; Pexelizumab_h5g1.1-scFv; Pexelizumab; PF-05082566; PF-05082568; Pidilizumab; Pinatuzumab_vedotin; Placulumab; Plozalizumab; Pogalizumab; Polatuzumab_vedotin; Ponezumab; Pritoxaximab; Pritumumab; Quilizumab; Racotumomab; Radretumab; Rafivirumab; Ralpancizumab; Ramucirumab; Ranibizivab; Ranibizumab; Refanezumab; REGN2810; rhuMab_HER2(9CI); rhuMab_HER2; rhuMAb-VEGF; Rilotumumab; Rinucumab; Risankizumab; Rituximab; Rivabazumab_pegol; Robatumumab; Roledumab; Romosozumab; Rontalizuab; Rontalizumab; Rovalpituzumab_tesirine; Rovelizumab; Ruplizumab; Sacituzumab_govitecan; Samalizumab; Sarilumab; Satumomab_pendetide; Secukinumab; Seribantumab; Setoxaximab; Sifalimumab; Siltuximab; Simtuzumab; Sirukumab; Sofituzumab_vedotin; Solanezumab; Solitomab; Sonepcizumab; Stamulumab; Suptavumab; Suvizumab; Tabalumab; Tacatuzuab; Tadocizumab; Talizumab; Tamtuvetmab; Tanezumab; Tarextumab; Tefibazumab; Tenatumomab; Teneliximab; Teplizumab; Teprotumumab; Tesidolumab; Tezepelumab; ThioMAb-chMA79b-HC(A118C); ThioMab-hu10A8.v1-HC(A118C); ThioMab-hu10A8.v1-HC(V205C); ThioMab-hu10A8.v1-LC(A118C); ThioMab-hu10A8.v1-LC(V205C); ThioMAb-huMA79b.v17-HC(A118C); ThioMAb-huMA79b.v18-HC(A118C); ThioMAb-huMA79b.v28-HC(A118C); ThioMAb-huMA79b.v28-LC(V205C); Ticilivab; Tigatuzumab; Tildrakizumab; Tisotumab_vedotin; Tocilizumab; Tosatoxumab; Tositumomab; Tovetumab; Tralokinumab; Trastuzuab; Trastuzumab_emtansine; Trastuzumab; TRC-105; Tregalizumab; Tremelimumab; Trevogrumab; Tucotuzumab_celmoleukin; Ublituximab; Ulocuplumab; Urelumab; Urtoxazumab; Ustekinumab; Vadastuximab_talirine; Vandortuzumab_vedotin; Vantictumab; Vanucizumab; Varlilumab; Vatelizumab; Vedolizumab; Veltuzumab; Vesencumab; Visilizumab; Volociximab; Vorsetuzumab; Vorsetuzumab_mafodotin; Yttrium_(90Y)_clivatuzumab_tetraxetan; Yttrium_Y_90_epratuzumab_tetraxetan; Yttrium_Y_90_epratuzumab; Zalutumumab; Zanolimumab; Zatuximab; Andecaliximab; Aprutumab; Azintuxizumab; Brazikumab; Cabiralizumab; Camrelizumab; Cosfroviximab; Crizanlizumab; Dezamizumab; Duvortuxizumab; Elezanumab; Emapalumab; Eptinezumab; Erenumab; Fremanezumab; Frunevetmab; Gatipotuzumab; Gedivumab; Gemetuzumab; Gilvetmab; Ifabotuzumab; Lacnotuzumab; Larcaviximab; Lendalizumab; Lesofavumab; Letolizumab; Losatuxizumab; Lupartumab; Lutikizumab; Oleclumab; Porgaviximab; Prezalumab; Ranevetmab; Remtolumab; Rosmantuzumab; Rozanolixizumab; Sapelizumab; Selicrelumab; Suvratoxumab; Tavolixizumab; Telisotuzumab; Telisotuzumab_vedotin; Timigutuzumab; Timolumab; Tomuzotuximab; Trastuzumab_duocarmazine; Varisacumab; Vunakizumab; Xentuzumab; anti-rabies_SO57; anti-rabies_SOJB; anti-rabies_SOJA; anti-rabies; anti-RSV_SITB; anti-alpha-toxin_4U6V; anti-IsdB_5D1Q; anti-IsdB_5D1X; anti-IsdB_5D1Z; anti-HIV b12; anti-HIV_2G12; anti-HIV_4E10; anti-HIV_VRC01; anti-HIV_PG9; anti-HIV_VRC07; anti-HIV_3BNC117; anti-HIV_10-1074; anti-HIV_PGT121; anti-HIV_PGDM1400; anti-HIV_N6; anti-HIV_10E8; anti-HIV_12A12; anti-HIV_12A21; anti-HIV_35022; anti-HIV_3BC176; anti-HIV_3BNC55; anti-HIV_3BNC60; anti-HIV_447-52D; anti-HIV_5H/I1-BMV-D5; anti-HIV_8ANC195; anti-HIV_CAP256-VRC26.01; anti-HIV_CAP256-VRC26.02; anti-HIV_CAP256-VRC26.03; anti-HIV_CAP256-VRC26.04; anti-HIV_CAP256-VRC26.05; anti-HIV_CAP256-VRC26.06; anti-HIV_CAP256-VRC26.07; anti-HIV_CAP256-VRC26.08; anti-HIV_CAP256-VRC26.09; anti-HIV_CAP256-VRC26.10; anti-HIV_CAP256-VRC26.11; anti-HIV_CAP256-VRC26.12; anti-HIV_CAP256-VRC26.I1; anti-HIV_CAP256-VRC26.I2; anti-HIV_CAP256-VRC26.UCA; anti-HIV_CH01; anti-HIV_CH02; anti-HIV_CH03; anti-HIV_CH04; anti-HIV_CH103; anti-HIV_M66.6; anti-HIV_NIH45-46; anti-HIV_PG16; anti-HIV_PGT122; anti-HIV_PGT123; anti-HIV_PGT125; anti-HIV_PGT126; anti-HIV_PGT127; anti-HIV_PGT128; anti-HIV_PGT130; anti-HIV_PGT131; anti-HIV_PGT135; anti-HIV_PGT136; anti-HIV_PGT137; anti-HIV_PGT141; anti-HIV_PGT142; anti-HIV_PGT143; anti-HIV_PGT144; anti-HIV_PGT145; anti-HIV_PGT151; anti-HIV_PGT152; anti-HIV_VRC-CH30; anti-HIV_VRC-CH31; anti-HIV_VRC-CH32; anti-HIV_VRC-CH33; anti-HIV_VRC-CH34; anti-HIV_VRC-PG04; anti-HIV_VRC-PG04b; anti-HIV_VRC-PG20; anti-HIV_VRC02; anti-HIV_VRC03; anti-HIV_VRC23; anti-HIV_5CCK; anti-HIV_5AWN; anti-HIV_3QEG; anti-HIV_1N0X; anti-HIV_3QEH; anti-HIV_2B1H; anti-HIV_3TNM; anti-HIV_3UJJ; anti-HIV_3UJI; anti-HIV_2QSC; anti-HIV_3MLZ; anti-HIV_3MLX; anti-HIV_3MLW; anti-HIV_3MLV; anti-HIV_3MLU; anti-HIV_3MLT; anti-HIV_3GO1; anti-HIV_4XCY; anti-HIV_4YBL; anti-HIV_4R4N; anti-HIV_4R4B; anti-HIV_3JUY; anti-HIV_4KG5; anti-HIV-1; anti-HIV_V3; anti-HIV_CD4bs; anti-HIV_V2; anti-HIV_C38-VRC18.02; anti-HIV_44-VRC13.02; anti-HIV_45; anti-HIV_cap256-206-252885; anti-HIV_cap256-206-249183; anti-HIV_cap256-206-220956; anti-HIV_cap256-206-220629; anti-HIV_cap256-206-200599; anti-HIV_cap256-206-186347; anti-HIV_cap256-206-186226; anti-HIV_cap256-206-179686; anti-HIV_cap256-206-173707; anti-HIV_cap256-206-173339; anti-HIV_cap256-206-172689; anti-HIV_cap256-206-162744; anti-HIV_cap256-206-146057; anti-HIV_cap256-206-139519; anti-HIV_cap256-206-136316; anti-HIV_cap256-206-116098; anti-HIV_cap256-206-115862; anti-HIV_cap256-206-107018; anti-HIV_cap256-206-098644; anti-HIV_cap256-206-098135; anti-HIV_cap256-206-096276; anti-HIV_cap256-206-092794; anti-HIV_cap256-206-086817; anti-HIV_cap256-206-086446; anti-HIV_cap256-206-086180; anti-HIV_cap256-206-083708; anti-HIV_cap256-206-079556; anti-HIV_cap256-206-078657; anti-HIV_cap256-206-075802; anti-HIV_cap256-206-069097; anti-HIV_cap256-206-067758; anti-HIV_cap256-206-057019; anti-HIV_cap256-206-055385; anti-HIV_cap256-206-053187; anti-HIV_cap256-206-053139; anti-HIV_cap256-206-050350; anti-HIV_cap256-206-046207; anti-HIV_cap256-206-043389; anti-HIV_cap256-206-042555; anti-HIV_cap256-206-029720; anti-HIV_cap256-206-028848; anti-HIV_cap256-206-027652; anti-HIV_cap256-206-024075; anti-HIV_cap256-206-008748; anti-HIV_cap256-206-008530; anti-HIV_cap256-176-723043; anti-HIV_cap256-176-600049; anti-HIV_cap256-176-531926; anti-HIV_cap256-176-504134; anti-HIV_cap256-119-186229; anti-HIV_cap256-119-183891; anti-HIV_cap256-119-183631; anti-HIV_cap256-119-182676; anti-HIV_cap256-119-180772; anti-HIV_cap256-119-180508; anti-HIV_cap256-119-180260; anti-HIV_cap256-119-180173; anti-HIV_cap256-119-179839; anti-HIV_cap256-119-179262; anti-HIV_cap256-119-178995; anti-HIV_cap256-119-178455; anti-HIV_cap256-119-177993; anti-HIV_cap256-119-177727; anti-HIV_cap256-119-176746; anti-HIV_cap256-119-176241; anti-HIV_cap256-119-175215; anti-HIV_cap256-119-173928; anti-HIV_cap256-119-173495; anti-HIV_cap256-119-172882; anti-HIV_cap256-119-172429; anti-HIV_cap256-119-172223; anti-HIV_cap256-119-171838; anti-HIV_cap256-119-171587; anti-HIV_cap256-119-169596; anti-HIV_cap256-119-169523; anti-HIV_cap256-119-169462; anti-HIV_cap256-119-169092; anti-HIV_cap256-119-168680; anti-HIV_cap256-119-166385; anti-HIV_cap256-119-165943; anti-HIV_cap256-119-165738; anti-HIV_cap256-119-164913; anti-HIV_cap256-119-164167; anti-HIV_cap256-119-163558; anti-HIV_cap256-119-162043; anti-HIV_cap256-119-161718; anti-HIV_cap256-119-161675; anti-HIV_cap256-119-161053; anti-HIV_cap256-119-159499; anti-HIV_cap256-119-159114; anti-HIV_cap256-119-156751; anti-HIV_cap256-119-155656; anti-HIV_cap256-119-154420; anti-HIV_cap256-119-153954; anti-HIV_cap256-119-153864; anti-HIV_cap256-119-153793; anti-HIV_cap256-119-153462; anti-HIV_cap256-119-153124; anti-HIV_cap256-119-153025; anti-HIV_cap256-119-152713; anti-HIV_cap256-119-151794; anti-HIV_cap256-119-150980; anti-HIV_cap256-119-148895; anti-HIV_cap256-119-148848; anti-HIV_cap256-119-148743; anti-HIV_cap256-119-148595; anti-HIV_cap256-119-148490; anti-HIV_cap256-119-148470; anti-HIV_cap256-119-148107; anti-HIV_cap256-119-147933; anti-HIV_cap256-119-147434; anti-HIV-cap256-119-146106; anti-HIV_cap256-119-145604; anti-HIV_cap256-119-143998; anti-HIV_cap256-119-143441; anti-HIV_cap256-119-141307; anti-HIV_cap256-119-140896; anti-HIV_cap256-119-140090; anti-HIV_cap256-119-140037; anti-HIV_cap256-119-139135; anti-HIV_cap256-119-137881; anti-HIV_cap256-119-137643; anti-HIV_cap256-119-137170; anti-HIV_cap256-119-136616; anti-HIV_cap256-119-136206; anti-HIV_cap256-119-135565; anti-HIV_cap256-119-135025; anti-HIV_cap256-119-133983; anti-HIV_cap256-119-133917; anti-HIV_cap256-119-132663; anti-HIV_cap256-119-132113; anti-HIV_cap256-119-131839; anti-HIV_cap256-119-130626; anti-HIV_cap256-119-130191; anti-HIV_cap256-119-129798; anti-HIV_cap256-119-128745; anti-HIV_cap256-119-128593; anti-HIV_cap256-119-128152; anti-HIV_cap256-119-127693; anti-HIV_cap256-119-126684; anti-HIV_cap256-119-126056; anti-HIV_cap256-119-125765; anti-HIV_cap256-119-125106; anti-HIV_cap256-119-124026; anti-HIV_cap256-119-121783; anti-HIV_cap256-119-121208; anti-HIV_cap256-119-120945; anti-HIV_cap256-119-118229; anti-HIV_cap256-119-118025; anti-HIV_cap256-119-117418; anti-HIV_cap256-119-117250; anti-HIV_cap256-119-117230; anti-HIV_cap256-119-116999; anti-HIV_cap256-119-116558; anti-HIV_cap256-119-116484; anti-HIV_cap256-119-114844; anti-HIV_cap256-119-114141; anti-HIV_cap256-119-111917; anti-HIV_cap256-119-111862; anti-HIV_cap256-119-110064; anti-HIV_cap256-119-109192; anti-HIV_cap256-119-108793; anti-HIV_cap256-119-108127; anti-HIV_cap256-119-107758; anti-HIV_cap256-119-107209; anti-HIV_cap256-119-107184; anti-HIV_cap256-119-106827; anti-HIV_cap256-119-106511; anti-HIV_cap256-119-106327; anti-HIV_cap256-119-105486; anti-HIV_cap256-119-105197; anti-HIV_cap256-119-104946; anti-HIV_cap256-119-103667; anti-HIV_cap256-119-103385; anti-HIV_cap256-119-103267; anti-HIV_cap256-119-103011; anti-HIV_cap256-119-102072; anti-HIV_cap256-119-101945; anti-HIV_cap256-119-101319; anti-HIV_cap256-119-100871; anti-HIV_cap256-119-100838; anti-HIV_cap256-119-100025; anti-HIV_cap256-119-100000; anti-HIV_cap256-119-098890; anti-HIV_cap256-119-098715; anti-HIV_cap256-119-098632; anti-HIV_cap256-119-097199; anti-HIV_cap256-119-096189; anti-HIV_cap256-119-094581; anti-HIV_cap256-119-094200; anti-HIV_cap256-119-094158; anti-HIV_cap256-119-092814; anti-HIV_cap256-119-092808; anti-HIV_cap256-119-092573; anti-HIV_cap256-119-090815; anti-HIV_cap256-119-090368; anti-HIV_cap256-119-089710; anti-HIV_cap256-119-088555; anti-HIV_cap256-119-087962; anti-HIV_cap256-119-086903; anti-HIV_cap256-119-086804; anti-HIV_cap256-119-085910; anti-HIV_cap256-119-085772; anti-HIV_cap256-119-084603; anti-HIV_cap256-119-084276; anti-HIV_cap256-119-082288; anti-HIV_cap256-119-080383; anti-HIV_cap256-119-079333; anti-HIV_cap256-119-078618; anti-HIV_cap256-119-077466; anti-HIV_cap256-119-076284; anti-HIV_cap256-119-074680; anti-HIV_cap256-119-074081; anti-HIV_cap256-119-071704; anti-HIV_cap256-119-071266; anti-HIV_cap256-119-069667; anti-HIV_cap256-119-069591; anti-HIV_cap256-119-068691; anti-HIV_cap256-119-068488; anti-HIV_cap256-119-067536; anti-HIV_cap256-119-065852; anti-HIV_cap256-119-065457; anti-HIV_cap256-119-064501; anti-HIV_cap256-119-063568; anti-HIV_cap256-119-063103; anti-HIV_cap256-119-061027; anti-HIV_cap256-119-058232; anti-HIV_cap256-119-057341; anti-HIV_cap256-119-056895; anti-HIV_cap256-119-056402; anti-HIV_cap256-119-056034; anti-HIV_cap256-119-055042; anti-HIV_cap256-119-054776; anti-HIV_cap256-119-054539; anti-HIV_cap256-119-054112; anti-HIV_cap256-119-053339; anti-HIV_cap256-119-052404; anti-HIV_cap256-119-051123; anti-HIV_cap256-119-051077; anti-HIV_cap256-119-050442; anti-HIV_cap256-119-049433; anti-HIV_cap256-119-047532; anti-HIV_cap256-119-047489; anti-HIV_cap256-119-046020; anti-HIV_cap256-119-044746; anti-HIV_cap256-119-044740; anti-HIV_cap256-119-043790; anti-HIV_cap256-119-042880; anti-HIV_cap256-119-042606; anti-HIV_cap256-119-042444; anti-HIV_cap256-119-040328; anti-HIV_cap256-119-040164; anti-HIV_cap256-119-039130; anti-HIV_cap256-119-038138; anti-HIV_cap256-119-037868; anti-HIV_cap256-119-037102; anti-HIV_cap256-119-036683; anti-HIV_cap256-119-036495; anti-HIV_cap256-119-035375; anti-HIV_cap256-119-035165; anti-HIV_cap256-119-035109; anti-HIV_cap256-119-033789; anti-HIV_cap256-119-033641; anti-HIV_cap256-119-032113; anti-HIV_cap256-119-031739; anti-HIV_cap256-119-030932; anti-HIV_cap256-119-030740; anti-HIV_cap256-119-030197; anti-HIV_cap256-119-027047; anti-HIV_cap256-119-026950; anti-HIV_cap256-119-026279; anti-HIV_cap256-119-025355; anti-HIV_cap256-119-025301; anti-HIV_cap256-119-025010; anti-HIV_cap256-119-024631; anti-HIV_cap256-119-024467; anti-HIV_cap256-119-023805; anti-HIV_cap256-119-021736; anti-HIV_cap256-119-021203; anti-HIV_cap256-119-020569; anti-HIV_cap256-119-019432; anti-HIV_cap256-119-018827; anti-HIV_cap256-119-018483; anti-HIV_cap256-119-018118; anti-HIV_cap256-119-017782; anti-HIV_cap256-119-017669; anti-HIV_cap256-119-016976; anti-HIV_cap256-119-015432; anti-HIV_cap256-119-015281; anti-HIV_cap256-119-014957; anti-HIV_cap256-119-014777; anti-HIV_cap256-119-014313; anti-HIV_cap256-119-014219; anti-HIV_cap256-119-013631; anti-HIV_cap256-119-012924; anti-HIV_cap256-119-011793; anti-HIV_cap256-119-011413; anti-HIV_cap256-119-011323; anti-HIV_cap256-119-011233; anti-HIV_cap256-119-009038; anti-HIV_cap256-119-008756; anti-HIV_cap256-119-008055; anti-HIV_cap256-119-006949; anti-HIV_cap256-119-006685; anti-HIV_cap256-119-006015; anti-HIV_cap256-119-005841; anti-HIV_cap256-119-005824; anti-HIV_cap256-119-005494; anti-HIV_cap256-119-004949; anti-HIV_cap256-119-004422; anti-HIV_cap256-119-003932; anti-HIV_cap256-119-003577; anti-HIV_cap256-119-002155; anti-HIV_cap256-119-002017; anti-HIV_cap256-119-001312; anti-HIV_cap256-119-001017; anti-HIV_cap256-119-000594; anti-HIV_cap256-059-241099; anti-HIV_cap256-059-207529; anti-HIV_cap256-059-205541; anti-HIV_cap256-059-188439; anti-HIV_cap256-059-187234; anti-HIV_cap256-059-187047; anti-HIV_cap256-059-186068; anti-HIV_cap256-059-182835; anti-HIV_cap256-059-176659; anti-HIV_cap256-059-172956; anti-HIV_cap256-059-171272; anti-HIV_cap256-059-168734; anti-HIV_cap256-059-155838; anti-HIV_cap256-059-149799; anti-HIV_cap256-059-148168; anti-HIV_cap256-059-144685; anti-HIV_cap256-059-140017; anti-HIV_cap256-059-137547; anti-HIV_cap256-059-131908; anti-HIV_cap256-059-116006; anti-HIV_cap256-059-115783; anti-HIV_cap256-059-114609; anti- HIV_cap256-059-113952; anti-HIV_cap256-059-113878; anti-HIV_cap256-059-113622; anti-HIV_cap256-059-109427; anti-HIV_cap256-059-109081; anti-HIV_cap256-059-107590; anti-HIV_cap256-059-107504; anti-HIV_cap256-059-099614; anti-HIV_cap256-059-098972; anti-HIV_cap256-059-097236; anti-HIV_cap256-059-091487; anti-HIV_cap256-059-089812; anti-HIV_cap256-059-088468; anti-HIV_cap256-059-088341; anti-HIV_cap256-059-086533; anti-HIV_cap256-059-086043; anti-HIV_cap256-059-084191; anti-HIV_cap256-059-082135; anti-HIV_cap256-059-079417; anti-HIV_cap256-059-076027; anti-HIV_cap256-059-075082; anti-HIV_cap256-059-072575; anti-HIV_cap256-059-071926; anti-HIV_cap256-059-069638; anti-HIV_cap256-059-069165; anti-HIV_cap256-059-068956; anti-HIV_cap256-059-068876; anti-HIV_cap256-059-067733; anti-HIV_cap256-059-067450; anti-HIV_cap256-059-065694; anti-HIV_cap256-059-065109; anti-HIV_cap256-059-065060; anti-HIV_cap256-059-064001; anti-HIV_cap256-059-063270; anti-HIV_cap256-059-061357; anti-HIV_cap256-059-059834; anti-HIV_cap256-059-059313; anti-HIV_cap256-059-057130; anti-HIV_cap256-059-050520; anti-HIV_cap256-059-049839; anti-HIV_cap256-059-048503; anti-HIV_cap256-059-045516; anti-HIV_cap256-059-044188; anti-HIV_cap256-059-044105; anti-HIV_cap256-059-042100; anti-HIV_cap256-059-040742; anti-HIV_cap256-059-040554; anti-HIV_cap256-059-039660; anti-HIV_cap256-059-039298; anti-HIV_cap256-059-037873; anti-HIV_cap256-059-037633; anti-HIV_cap256-059-036817; anti-HIV_cap256-059-032787; anti-HIV_cap256-059-032427; anti-HIV_cap256-059-029390; anti-HIV_cap256-059-027877; anti-HIV_cap256-059-026640; anti-HIV_cap256-059-026017; anti-HIV_cap256-059-024100; anti-HIV_cap256-059-023966; anti-HIV_cap256-059-020534; anti-HIV_cap256-059-019513; anti-HIV_cap256-059-012963; anti-HIV_cap256-059-010396; anti-HIV_cap256-059-008136; anti-HIV_cap256-059-006147; anti-HIV_cap256-059-005081; anti-HIV_cap256-059-005006; anti-HIV_cap256-059-004451; anti-HIV_cap256-059-003571; anti-HIV_cap256-059-003449; anti-HIV_cap256-059-002712; anti-HIV_cap256-059-001573; anti-HIV_cap256-059-001379; anti-HIV_cap256-059-001029; anti-HIV_cap256-048-165087; anti-HIV_cap256-048-158861; anti-HIV_cap256-048-158280; anti-HIV_cap256-048-157928; anti-HIV_cap256-048-157056; anti-HIV_cap256-048-156422; anti-HIV_cap256-048-152863; anti-HIV_cap256-048-152770; anti-HIV_cap256-048-150027; anti-HIV_cap256-048-148246; anti-HIV_cap256-048-147428; anti-HIV_cap256-048-146603; anti-HIV_cap256-048-145735; anti-HIV_cap256-048-145116; anti-HIV_cap256-048-144077; anti-HIV_cap256-048-142876; anti-HIV_cap256-048-140582; anti-HIV_cap256-048-139355; anti-HIV_cap256-048-139151; anti-HIV_cap256-048-137672; anti-HIV_cap256-048-137506; anti-HIV_cap256-048-137270; anti-HIV_cap256-048-135447; anti-HIV_cap256-048-131966; anti-HIV_cap256-048-131008; anti-HIV_cap256-048-129369; anti-HIV_cap256-048-128476; anti-HIV_cap256-048-128270; anti-HIV_cap256-048-126220; anti-HIV_cap256-048-125713; anti-HIV_cap256-048-123934; anti-HIV_cap256-048-122673; anti-HIV_cap256-048-122208; anti-HIV_cap256-048-121552; anti-HIV_cap256-048-120643; anti-HIV_cap256-048-118458; anti-HIV_cap256-048-118112; anti-HIV_cap256-048-116469; anti-HIV_cap256-048-113917; anti-HIV_cap256-048-112368; anti-HIV_cap256-048-112047; anti-HIV_cap256-048-112029; anti-HIV_cap256-048-110957; anti-HIV_cap256-048-110526; anti-HIV_cap256-048-109336; anti-HIV_cap256-048-108152; anti-HIV_cap256-048-107799; anti-HIV_cap256-048-107384; anti-HIV_cap256-048-106530; anti-HIV_cap256-048-106464; anti-HIV_cap256-048-106411; anti-HIV_cap256-048-106306; anti-HIV_cap256-048-104496; anti-HIV_cap256-048-103074; anti-HIV_cap256-048-100832; anti-HIV_cap256-048-100188; anti-HIV_cap256-048-099645; anti-HIV_cap256-048-098137; anti-HIV_cap256-048-097878; anti-HIV_cap256-048-097510; anti-HIV_cap256-048-097313; anti-HIV_cap256-048-096626; anti-HIV_cap256-048-096483; anti-HIV_cap256-048-095691; anti-HIV_cap256-048-095525; anti-HIV_cap256-048-094783; anti-HIV_cap256-048-094356; anti-HIV_cap256-048-090756; anti-HIV_cap256-048-089065; anti-HIV_cap256-048-084986; anti-HIV_cap256-048-083355; anti-HIV_cap256-048-082462; anti-HIV_cap256-048-082246; anti-HIV_cap256-048-080752; anti-HIV_cap256-048-078409; anti-HIV_cap256-048-078273; anti-HIV_cap256-048-078062; anti-HIV_cap256-048-077798; anti-HIV_cap256-048-073853; anti-HIV_cap256-048-071661; anti-HIV_cap256-048-071360; anti-HIV_cap256-048-070955; anti-HIV_cap256-048-070061; anti-HIV_cap256-048-069669; anti-HIV_cap256-048-069205; anti-HIV_cap256-048-068882; anti-HIV_cap256-048-067764; anti-HIV_cap256-048-066845; anti-HIV_cap256-048-065226; anti-HIV_cap256-048-063717; anti-HIV_cap256-048-063150; anti-HIV_cap256-048-062431; anti-HIV_cap256-048-060745; anti-HIV_cap256-048-060420; anti-HIV_cap256-048-060014; anti-HIV_cap256-048-059747; anti-HIV_cap256-048-058393; anti-HIV_cap256-048-058159; anti-HIV_cap256-048-057127; anti-HIV_cap256-048-056251; anti-HIV_cap256-048-055421; anti-HIV_cap256-048-054989; anti-HIV_cap256-048-054759; anti-HIV_cap256-048-052573; anti-HIV_cap256-048-051477; anti-HIV_cap256-048-051299; anti-HIV_cap256-048-050815; anti-HIV_cap256-048-049884; anti-HIV_cap256-048-049170; anti-HIV_cap256-048-048531; anti-HIV_cap256-048-048259; anti-HIV_cap256-048-047313; anti-HIV_cap256-048-046596; anti-HIV_cap256-048-044781; anti-HIV_cap256-048-042599; anti-HIV_cap256-048-041276; anti-HIV_cap256-048-040200; anti-HIV_cap256-048-039061; anti-HIV_cap256-048-038515; anti-HIV_cap256-048-038255; anti-HIV_cap256-048-038177; anti-HIV_cap256-048-035513; anti-HIV_cap256-048-034112; anti-HIV_cap256-048-033983; anti-HIV_cap256-048-032688; anti-HIV_cap256-048-031092; anti-HIV_cap256-048-030464; anti-HIV_cap256-048-030289; anti-HIV_cap256-048-030261; anti-HIV_cap256-048-029362; anti-HIV_cap256-048-027638; anti-HIV_cap256-048-027613; anti-HIV_cap256-048-026627; anti-HIV_cap256-048-026239; anti-HIV_cap256-048-025518; anti-HIV_cap256-048-024854; anti-HIV_cap256-048-024537; anti-HIV_cap256-048-021781; anti-HIV_cap256-048-021758; anti-HIV_cap256-048-020988; anti-HIV_cap256-048-020663; anti-HIV_cap256-048-020590; anti-HIV_cap256-048-019765; anti-HIV_cap256-048-019254; anti-HIV_cap256-048-018073; anti-HIV_cap256-048-016775; anti-HIV_cap256-048-016069; anti-HIV_cap256-048-015867; anti-HIV_cap256-048-015673; anti-HIV_cap256-048-015156; anti-HIV_cap256-048-014521; anti-HIV_cap256-048-014475; anti-HIV_cap256-048-013798; anti-HIV_cap256-048-013271; anti-HIV_cap256-048-013180; anti-HIV_cap256-048-012148; anti-HIV_cap256-048-011870; anti-HIV_cap256-048-011530; anti-HIV_cap256-048-010968; anti-HIV_cap256-048-010224; anti-HIV_cap256-048-009749; anti-HIV_cap256-048-009623; anti-HIV_cap256-048-008234; anti-HIV_cap256-048-008149; anti-HIV_cap256-048-007301; anti-HIV_cap256-048-007174; anti-HIV_cap256-048-007079; anti-HIV_cap256-048-007033; anti-HIV_cap256-048-006128; anti-HIV_cap256-048-005999; anti-HIV_cap256-048-005394; anti-HIV_cap256-048-004226; anti-HIV_cap256-048-004097; anti-HIV_cap256-048-003289; anti-HIV_cap256-048-002601; anti-HIV_cap256-048-002129; anti-HIV_cap256-048-001875; anti-HIV_cap256-048-001302; anti-HIV_cap256-048-001203; anti-HIV_cap256-048-000383; anti-HIV_cap256-038-261791; anti-HIV_cap256-038-241540; anti-HIV_cap256-038-235677; anti-HIV_cap256-038-234314; anti-HIV_cap256-038-234273; anti-HIV_cap256-038-223164; anti-HIV_cap256-038-220289; anti-HIV_cap256-038-220020; anti-HIV_cap256-038-216853; anti-HIV_cap256-038-213466; anti-HIV_cap256-038-213212; anti-HIV_cap256-038-213120; anti-HIV_cap256-038-212592; anti-HIV_cap256-038-211790; anti-HIV_cap256-038-209916; anti-HIV_cap256-038-207938; anti-HIV_cap256-038-202245; anti-HIV_cap256-038-197721; anti-HIV_cap256-038-196679; anti-HIV_cap256-038-196118; anti-HIV_cap256-038-195382; anti-HIV_cap256-038-180001; anti-HIV_cap256-038-178021; anti-HIV_cap256-038-177104; anti-HIV_cap256-038-171261; anti-HIV_cap256-038-169090; anti-HIV_cap256-038-168705; anti-HIV_cap256-038-167685; anti-HIV_cap256-038-158775; anti-HIV_cap256-038-157318; anti-HIV_cap256-038-153058; anti-HIV_cap256-038-150027; anti-HIV_cap256-038-146372; anti-HIV_cap256-038-141868; anti-HIV_cap256-038-141616; anti-HIV_cap256-038-127989; anti-HIV_cap256-038-118109; anti-HIV_cap256-038-112226; anti-HIV_cap256-038-105918; anti-HIV_cap256-038-104487; anti-HIV_cap256-038-102308; anti-HIV_cap256-038-091115; anti-HIV_cap256-038-090262; anti-HIV_cap256-038-083260; anti-HIV_cap256-038-080981; anti-HIV_cap256-038-080873; anti-HIV_cap256-038-074413; anti-HIV_cap256-038-073153; anti-HIV_cap256-038-064227; anti-HIV_cap256-038-061640; anti-HIV_cap256-038-059482; anti-HIV_cap256-038-054000; anti-HIV_cap256-038-050554; anti-HIV_cap256-038-044256; anti-HIV_cap256-038-040944; anti-HIV_cap256-038-040090; anti-HIV_cap256-038-032874; anti-HIV_cap256-038-025899; anti-HIV_cap256-038-024581; anti-HIV_cap256-038-013345; anti-HIV_cap256-038-011559; anti-HIV_cap256-038-009634; anti-HIV_cap256-038-006730; anti-HIV_cap256-038-004887; anti-HIV_cap256-038-004840; anti-HIV_cap256-038-002181; anti-HIV_cap256-038-001902; anti-HIV_cap256-038-000976; anti-HIV_cap256-038-000384; anti-HIV_cap206-314431; anti-HIV_206-247594; anti-HIV_206-116890; anti-HIV_206-072383; anti-HIV_206-037527; anti-HIV_206-009095; anti-HIV_176-503620; anti-HIV_176-478726; anti-HIV_176-245056; anti-HIV_176-164413; anti-HIV_176-094308; anti-HIV_176-065321; anti-HIV_119-099719; anti-HIV_119-099536; anti-HIV_119-098907; anti-HIV_119-098555; anti-HIV_119-097828; anti-HIV_119-096480; anti-HIV_119-095664; anti-HIV_119-095212; anti-HIV_119-094773; anti-HIV_119-094508; anti-HIV_119-093795; anti-HIV_119-093732; anti-HIV_119-092903; anti-HIV_119-092284; anti-HIV_119-091586; anti-HIV_119-091023; anti-HIV_119-090334; anti-HIV_119-088694; anti-HIV_119-088499; anti-HIV_119-088298; anti-HIV_119-087488; anti-HIV_119-087423; anti-HIV_119-087371; anti-HIV_119-087279; anti-HIV_119-087146; anti-HIV_119-087048; anti-HIV_119-085802; anti-HIV_119-085784; anti-HIV_119-085370; anti-HIV_119-085276; anti-HIV_119-084885; anti-HIV_119-084874; anti-HIV_119-084691; anti-HIV_119-083793; anti-HIV_119-083163; anti-HIV_119-082331; anti-HIV_119-082070; anti-HIV_119-081512; anti-HIV_119-080816; anti-HIV_119-079302; anti-HIV_119-079292; anti-HIV_119-079289; anti-HIV_119-078935; anti-HIV_119-078702; anti-HIV_119-078593; anti-HIV_119-077708; anti-HIV_119-076904; anti-HIV_119-075862; anti-HIV_119-075465; anti-HIV_119-074822; anti-HIV_119-074629; anti-HIV_119-074500; anti-HIV_119-073911; anti-HIV_119-072765; anti-HIV_119-072313; anti-HIV_119-072280; anti-HIV_119-071693; anti-HIV_119-071353; anti-HIV_119-069711; anti-HIV_119-069061; anti-HIV_119-068202; anti-HIV_119-068063; anti-HIV_119-067980; anti-HIV_119-067866; anti-HIV_119-067756; anti-HIV_119-066859; anti-HIV_119-065821; anti-HIV_119-065191; anti-HIV_119-064667; anti-HIV_119-063791; anti-HIV_119-062989; anti-HIV_119-062286; anti-HIV_119-061416; anti-HIV_119-061344; anti-HIV_119-060240; anti-HIV_119-060184; anti-HIV_119-058035; anti-HIV_119-057858; anti-HIV_119-057473; anti-HIV_119-057090; anti-HIV_119-055754; anti-HIV_119-054899; anti-HIV_119-054501; anti-HIV_119-051867; anti-HIV_119-051814; anti-HIV_119-051567; anti-HIV_119-051483; anti-HIV_119-050913; anti-HIV_119-050187; anti-HIV_119-049069; anti-HIV_119-048517; anti-HIV_119-048470; anti-HIV_119-048303; anti-HIV_119-048021; anti-HIV_119-047928; anti-HIV_119-047384; anti-HIV_119-047145; anti-HIV_119-046752; anti-HIV_119-046660; anti-HIV_119-046202; anti-HIV_119-045790; anti-HIV_119-044670; anti-HIV_119-044140; anti-HIV_119-042776; anti-HIV_119-042581; anti-HIV_119-040905; anti-HIV_119-040322; anti-HIV_119-039892; anti-HIV_119-039764; anti-HIV_119-039188; anti-HIV_119-039058; anti-HIV_119-038837; anti-HIV_119-038396; anti-HIV_119-036918; anti-HIV_119-036592; anti-HIV_119-036310; anti-HIV_119-035618; anti-HIV_119-035569; anti-HIV_119-035466; anti-HIV_119-035157; anti-HIV_119-035121; anti-HIV_119-035046; anti-HIV_119-034754; anti-HIV_119-034318; anti-HIV_119-033780; anti-HIV_119-033632; anti-HIV_119-033183; anti-HIV_119-030696; anti-HIV_119-030059; anti-HIV_119-029589; anti-HIV_119-029448; anti-HIV_119-029220; anti-HIV_119-028317; anti-HIV_119-028165; anti-HIV_119-027147; anti-HIV_119-026743; anti-HIV_119-026508; anti-HIV_119-025683; anti-HIV_119-025614; anti-HIV_119-025548; anti-HIV_119-025526; anti-HIV_119-023552; anti-HIV_119-023092; anti-HIV_119-022793; anti-HIV_119-022395; anti-HIV_119-022334; anti-HIV_119-021866; anti-HIV_119-021278; anti-HIV_119-021183; anti-HIV_119-019376; anti-HIV_119-019238; anti-HIV_119-018500; anti-HIV_119-018318; anti-HIV_119-018218; anti-HIV_119-017876; anti-HIV_119-017740; anti-HIV_119-017128; anti-HIV_119-017044; anti-HIV_119-016644; anti-HIV_119-015878; anti-HIV_119-015538; anti-HIV_119-015455; anti-HIV_119-014425; anti-HIV_119-013582; anti-HIV_119-013364; anti-HIV_119-012886; anti-HIV_119-012249; anti-HIV_119-012161; anti-HIV_119-012110; anti-HIV_119-012100; anti-HIV_119-011651; anti-HIV_119-011479; anti-HIV_119-011232; anti-HIV_119-011175; anti-HIV_119-008396; anti-HIV_119-007148; anti-HIV_119-007029; anti-HIV_119-004707; anti-HIV_119-003910; anti-HIV_119-002450; anti-HIV_119-001552; anti-HIV_059-188169; anti-HIV_059-183739; anti-HIV_059-182376; anti-HIV_059-182199; anti-HIV_059-169202; anti-HIV_059-155645; anti-HIV_059-151619; anti-HIV_059-146503; anti-HIV_059-136098; anti-HIV_059-105516; anti-HIV_059-095709; anti-HIV_059-069468; anti-HIV_059-060026; anti-HIV_059-053668; anti-HIV_059-052864; anti-HIV_059-050968; anti-HIV_059-046422; anti-HIV_059-045120; anti-HIV_059-039932; anti-HIV_059-038595; anti-HIV_059-035082; anti-HIV_059-029204; anti-HIV_059-025235; anti-HIV_059-015192; anti-HIV_059-007060; anti-HIV_059-006953; anti-HIV_059-005953; anti-HIV_059-003725; anti-HIV_059-002618; anti-HIV_059-001522; anti-HIV_059-000731; anti-HIV_059-000634; anti-HIV_048-250757; anti-HIV_048-250716; anti-HIV_048-250463; anti-HIV_048-248153; anti-HIV_048-247532; anti-HIV_048-245846; anti-HIV_048-244016; anti-HIV_048-243682; anti-HIV_048-243588; anti-HIV_048-241775; anti-HIV_048-237996; anti-HIV_048-237730; anti-HIV_048-237253; anti-HIV_048-234100; anti-HIV_048-230882; anti-HIV_048-229473; anti-HIV_048-228238; anti-HIV_048-228027; anti-HIV_048-227795; anti-HIV_048-227770; anti-HIV_048-225298; anti-HIV_048-225090; anti-HIV_048-224187; anti-HIV_048-223055; anti-HIV_048-222711; anti-HIV_048-221209; anti-HIV_048-220629; anti-HIV_048-219430; anti-HIV_048-216250; anti-HIV_048-216133; anti-HIV_048-214886; anti-HIV_048-214709; anti-HIV_048-214001; anti-HIV_048-213230; anti-HIV_048-212574; anti-HIV_048-212207; anti-HIV_048-209146; anti-HIV_048-208206; anti-HIV_048-208194; anti-HIV_048-207744; anti-HIV_048-206501; anti-HIV_048-204221; anti-HIV_048-204015; anti-HIV_048-201240; anti-HIV_048-200455; anti-HIV_048-200319; anti-HIV_048-197896; anti-HIV_048-193813; anti-HIV_048-192098; anti-HIV_048-191786; anti-HIV_048-188746; anti-HIV_048-185937; anti-HIV_048-184849; anti-HIV_048-183089; anti-HIV_048-181509; anti-HIV_048-180990; anti-HIV_048-177532; anti-HIV_048-177426; anti-HIV_048-177389; anti-HIV_048-174266; anti-HIV_048-172847; anti-HIV_048-172845; anti-HIV_048-172363; anti-HIV_048-171609; anti-HIV_048-170705; anti-HIV_048-168381; anti-HIV_048-166619; anti-HIV_048-162036; anti-HIV_048-160042; anti-HIV_048-159676; anti-HIV_048-159500; anti-HIV_048-159421; anti-HIV_048-159333; anti-HIV_048-158932; anti-HIV_048-155811; anti-HIV_048-155464; anti-HIV_048-155392; anti-HIV_048-155389; anti-HIV_048-154449; anti-HIV_048-153379; anti-HIV_048-153171; anti-HIV_048-152324; anti-HIV_048-146102; anti-HIV_048-145984; anti-HIV_048-145371; anti-HIV_048-144907; anti-HIV_048-142298; anti-HIV_048-142277; anti-HIV_048-141934; anti-HIV_048-141207; anti-HIV_048-140796; anti-HIV_048-139893; anti-HIV_048-138820; anti-HIV_048-135858; anti-HIV_048-134968; anti-HIV_048-134312; anti-HIV_048-132253; anti-HIV_048-130710; anti-HIV_048-128564; anti-HIV_048-126702; anti-HIV_048-124521; anti-HIV_048-122740; anti-HIV_048-119536; anti-HIV_048-116929; anti-HIV_048-116577; anti-HIV_048-116046; anti-HIV_048-115875; anti-HIV_048-115599; anti-HIV_048-113988; anti-HIV_048-112989; anti-HIV_048-112435; anti-HIV_048-111339; anti-HIV_048-111055; anti-HIV_048-111027; anti-HIV_048-109721; anti-HIV_048-109666; anti-HIV_048-109196; anti-HIV_048-109051; anti-HIV_048-108570; anti-HIV_048-108033; anti-HIV_048-107279; anti-HIV_048-106271; anti-HIV_048-106054; anti-HIV_048-104848; anti-HIV_048-104638; anti-HIV_048-104567; anti-HIV_048-102804; anti-HIV_048-101676; anti-HIV_048-097603; anti-HIV_048-097107; anti-HIV_048-096871; anti-HIV_048-096668; anti-HIV_048-095236; anti-HIV_048-094155; anti-HIV_048-093219; anti-HIV_048-092976; anti-HIV_048-090866; anti-HIV_048-090650; anti-HIV_048-089009; anti-HIV_048-088654; anti-HIV_048-086513; anti-HIV_048-086024; anti-HIV_048-085857; anti-HIV_048-084277; anti-HIV_048-084245; anti-HIV_048-082487; anti-HIV_048-081787; anti-HIV_048-081062; anti-HIV_048-079639; anti-HIV_048-079126; anti-HIV_048-073118; anti-HIV_048-070264; anti-HIV_048-069426; anti-HIV_048-068564; anti-HIV_048-068345; anti-HIV_048-067337; anti-HIV_048-067180; anti-HIV_048-063017; anti-HIV_048-061885; anti-HIV_048-061671; anti-HIV_048-060700; anti-HIV_048-060592; anti-HIV_048-060300; anti-HIV_048-059141; anti-HIV_048-057777; anti-HIV_048-056928; anti-HIV_048-056131; anti-HIV_048-055864; anti-HIV_048-055094; anti-HIV_048-054343; anti-HIV_048-054193; anti-HIV_048-052521; anti-HIV_048-049037; anti-HIV_048-048720; anti-HIV_048-048542; anti-HIV_048-047777; anti-HIV_048-046841; anti-HIV_048-046202; anti-HIV_048-046059; anti-HIV_048-043568; anti-HIV_048-042713; anti-HIV_048-042440; anti-HIV_048-040511; anti-HIV_048-039195; anti-HIV_048-036935; anti-HIV_048-034478; anti-HIV_048-031641; anti-HIV_048-029760; anti-HIV_048-027970; anti-HIV_048-027337; anti-HIV_048-027217; anti-HIV_048-026760; anti-HIV_048-024800; anti-HIV_048-024313; anti-HIV_048-021748; anti-HIV_048-020991; anti-HIV_048-020340; anti-HIV_048-019993; anti-HIV_048-019947; anti-HIV_048-017871; anti-HIV_048-015931; anti-HIV_048-015920; anti-HIV_048-013898; anti-HIV_048-013429; anti-HIV_048-012358; anti-HIV_048-011158; anti-HIV_048-010720; anti-HIV_048-009445; anti-HIV_048-006126; anti-HIV_048-005652; anti-HIV_048-005532; anti-HIV_048-005189; anti-HIV_048-005088; anti-HIV_048-004023; anti-HIV_048-001580; anti-HIV_038-221120; anti-HIV_038-197677; anti-HIV_038-196765; anti-HIV_038-186200; anti-HIV_038-126170; anti-HIV_038-108545; anti-HIV_038-107263; anti-HIV_038-104530; anti-HIV_038-099169; anti-HIV_038-075067; anti-HIV_038-072368; anti-HIV_038-068503; anti-HIV_038-068016; anti-HIV_038-063958; anti-HIV_038-033733; anti-HIV_038-030557; anti-HIV_038-024298; anti-HIV_038-011154; anti-HIV_5CIN; anti-HIV_5CIL; anti-HIV_5CIP; anti-HIV_4JKP; anti-HIV_3TNN; anti-HIV_3BQU; anti-HIV_IgG; anti-HIV_4P9M; anti-HIV_4P9H; anti-HIV_Ig; anti-HIV; anti-influenza; anti-influenza_Apo; anti-influenza-A; anti-OX40; or a fragment or variant thereof.

More preferably, the at least one coding sequence of the RNA according to the present invention encodes an antibody or a fragment or variant thereof comprising an amino acid sequence selected from the group consisting of amino acid sequences according to SEQ ID NOs: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, and 61730; or a fragment or variant of any one of said amino acid sequences.

According to certain preferred embodiments of the present invention, the RNA is mono-, bi-, or multicistronic as defined herein. The coding sequences in a bi- or multicistronic RNA preferably encode distinct antibodies as defined herein or distinct fragments or variants thereof. In particular, an RNA according to the present invention preferably encodes a full-length (complete) antibody in a multicistronic manner, e.g. by encoding the heavy chain (or a fragment thereof, e.g. the heavy chain variable region) and the light chain (or a fragment thereof, e.g. the light chain variable region) of the same antibody in separate cistrons on one single RNA (molecule). Accordingly, the RNA according to the present invention is preferably bicistronic or multicistronic. However, it is also preferred that the RNA according to the present invention is monocistronic. For example, a full-length (complete) antibody may be encoded in one single cistron, e.g. if the heavy chain (or a fragment thereof, e.g. the heavy chain variable region) and the light chain (or a fragment thereof, e.g. the light chain variable region) are connected via a peptidic linker (linker sequence) as described below. A monocistronic RNA according to the present invention may also encode only a fragment of an antibody, in particular the heavy chain (or a fragment thereof, e.g. the heavy chain variable region) only, or the light chain (or a fragment thereof, e.g. the light chain variable region) only—with the corresponding the heavy chain (or a fragment thereof, e.g. the heavy chain variable region) or the light chain (or a fragment thereof, e.g. the light chain variable region) being encoded (preferably in a similar monocistronic manner) by another RNA (molecule). This embodiment is in particular preferred in the context of a combination of RNA's according to the present invention as described herein.

Preferably, the coding sequences encoding two or more antibodies or fragments thereof may be separated in the bi- or multicistronic RNA by at least one IRES (internal ribosomal entry site) sequence, as defined below. Thus, the term “encoding two or more antibodies or fragments thereof” may mean, without being limited thereto, that the bi- or even multicistronic RNA, may encode e.g. at least two, three, four, five, six or more (preferably different) antibodies or fragments thereof of the antibodies or their fragments within the definitions provided herein. More preferably, without being limited thereto, the bi- or even multicistronic mRNA, may encode, for example, at least two, three, four, five, six or more (preferably different) antibodies as defined herein or their fragments or variants as defined herein. In this context, a so-called IRES (internal ribosomal entry site) sequence as defined above can function as a sole ribosome binding site, but it can also serve to provide a bi- or even multicistronic mRNA as defined above, which encodes several antibodies, which are to be translated by the ribosomes independently of one another. Examples of IRES sequences, which can be used according to the invention, are those from picornaviruses (e.g. FMDV), pestiviruses (CFFV), polioviruses (PV), encephalomyocarditis viruses (ECMV), foot and mouth disease viruses (FMDV), hepatitis C viruses (HCV), classical swine fever viruses (CSFV), mouse leukoma virus (MLV), simian immunodeficiency viruses (SIV) or cricket paralysis viruses (CrPV).

According to a further embodiment the at least one coding sequence of the RNA according to the invention may encode at least two, three, four, five, six, seven, eight and more antibodies (or fragments or variants thereof) as defined herein linked with or without an amino acid linker sequence, wherein said linker sequence can comprise rigid linkers, flexible linkers, cleavable linkers (e.g., self-cleaving peptides) or a combination thereof. Therein, the antibodies may be identical or different or a combination thereof. Particular antibody combinations can be encoded by said mRNA encoding at least two antibodies as explained herein (also referred to herein as ‘multi-antibody-constructs/mRNA’). In this way the RNA according to the present invention may, for example, encode the heavy chain and the corresponding light chain of an antibody (such that one RNA molecule is sufficient to encode the complete antibody including heavy and light chain) or the heavy chain variable region and the light chain variable region of an antibody (fragment).

Preferably, the at least one coding sequence of the RNA according to the invention comprises at least two, three, four, five, six, seven, eight and more nucleic acid sequences having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

Preferably, the RNA comprising at least one coding sequence as defined herein typically comprises a length of about 50 to about 20000, or 100 to about 20000 nucleotides, preferably of about 250 to about 20000 nucleotides, more preferably of about 500 to about 10000, even more preferably of about 500 to about 5000.

The RNA according to the invention may further be single stranded or double stranded. When provided as a double stranded RNA, the RNA according to the invention preferably comprises a sense and a corresponding antisense strand.

In a preferred embodiment, the RNA comprising at least one coding sequence as defined herein is an mRNA, a viral RNA or a replicon RNA.

According to a further embodiment, the RNA, preferably an mRNA, according to the invention is a modified RNA, preferably a modified RNA as described herein. In this context, a modification as defined herein preferably leads to a stabilization of the RNA according to the invention. More preferably, the invention thus provides a stabilized RNA comprising at least one coding sequence as defined herein.

According to one embodiment, the RNA of the present invention may thus be provided as a “stabilized mRNA”, that is to say as an RNA that is essentially resistant to in vivo degradation (e.g. by an exo- or endo-nuclease). Such stabilization can be effected, for example, by a modified phosphate backbone of the RNA of the present invention. A backbone modification in connection with the present invention is a modification in which phosphates of the backbone of the nucleotides contained in the RNA are chemically modified. Nucleotides that may be preferably used in this connection contain e.g. a phosphorothioate-modified phosphate backbone, preferably at least one of the phosphate oxygens contained in the phosphate backbone being replaced by a sulfur atom. Stabilized RNAs may further include, for example: non-ionic phosphate analogues, such as, for example, alkyl and aryl phosphonates, in which the charged phosphonate oxygen is replaced by an alkyl or aryl group, or phosphodiesters and alkylphosphotriesters, in which the charged oxygen residue is present in alkylated form. Such backbone modifications typically include, without implying any limitation, modifications from the group consisting of methylphosphonates, phosphoramidates and phosphorothioates (e.g. cytidine-5′-O-(1-thiophosphate)).

In the following, specific modifications are described, which are preferably capable of “stabilizing” the RNA as defined herein.

Chemical Modifications:

The term “RNA modification” as used herein may refer to chemical modifications comprising backbone modifications as well as sugar modifications or base modifications.

In this context, a modified RNA as defined herein may contain nucleotide analogues/modifications, e.g. backbone modifications, sugar modifications or base modifications. A backbone modification in connection with the present invention is a modification, in which phosphates of the backbone of the nucleotides contained in an RNA as defined herein are chemically modified. A sugar modification in connection with the present invention is a chemical modification of the sugar of the nucleotides of the RNA as defined herein. Furthermore, a base modification in connection with the present invention is a chemical modification of the base moiety of the nucleotides of the RNA. In this context, nucleotide analogues or modifications are preferably selected from nucleotide analogues, which are applicable for transcription and/or translation.

Sugar Modifications:

The modified nucleosides and nucleotides, which may be incorporated into a modified RNA as described herein, can be modified in the sugar moiety. For example, the 2′ hydroxyl group (OH) can be modified or replaced with a number of different “oxy” or “deoxy” substituents. Examples of “oxy”-2′ hydroxyl group modifications include, but are not limited to, alkoxy or aryloxy (—OR, e.g., R═H, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or sugar); polyethyleneglycols (PEG), —O(CH₂CH₂O)nCH₂CH₂OR; “locked” nucleic acids (LNA) in which the 2′ hydroxyl is connected, e.g., by a methylene bridge, to the 4′ carbon of the same ribose sugar; and amino groups (—O-amino, wherein the amino group, e.g., NRR, can be alkylamino, dialkylamino, heterocyclyl, arylamino, diarylamino, heteroarylamino, or diheteroaryl amino, ethylene diamine, polyamino) or aminoalkoxy.

“Deoxy” modifications include hydrogen, amino (e.g. NH₂; alkylamino, dialkylamino, heterocyclyl, arylamino, diaryl amino, heteroaryl amino, diheteroaryl amino, or amino acid); or the amino group can be attached to the sugar through a linker, wherein the linker comprises one or more of the atoms C, N, and O.

The sugar group can also contain one or more carbons that possess the opposite stereochemical configuration than that of the corresponding carbon in ribose. Thus, a modified RNA can include nucleotides containing, for instance, arabinose as the sugar.

Backbone Modifications:

The phosphate backbone may further be modified in the modified nucleosides and nucleotides, which may be incorporated into a modified RNA as described herein. The phosphate groups of the backbone can be modified by replacing one or more of the oxygen atoms with a different substituent. Further, the modified nucleosides and nucleotides can include the full replacement of an unmodified phosphate moiety with a modified phosphate as described herein. Examples of modified phosphate groups include, but are not limited to, phosphorothioate, phosphoroselenates, borano phosphates, borano phosphate esters, hydrogen phosphonates, phosphoroamidates, alkyl or aryl phosphonates and phosphotriesters. Phosphorodithioates have both non-linking oxygens replaced by sulfur. The phosphate linker can also be modified by the replacement of a linking oxygen with nitrogen (bridged phosphoroamidates), sulfur (bridged phosphorothioates) and carbon (bridged methylene-phosphonates).

Base Modifications:

The modified nucleosides and nucleotides, which may be incorporated into a modified RNA as described herein can further be modified in the nucleobase moiety. Examples of nucleobases found in RNA include, but are not limited to, adenine, guanine, cytosine and uracil. For example, the nucleosides and nucleotides described herein can be chemically modified on the major groove face. In some embodiments, the major groove chemical modifications can include an amino group, a thiol group, an alkyl group, or a halo group.

In particularly preferred embodiments of the present invention, the nucleotide analogues/modifications are selected from base modifications, which are preferably selected from 2-amino-6-chloropurineriboside-5′-triphosphate, 2-Aminopurine-riboside-5′-triphosphate; 2-aminoadenosine-5′-triphosphate, 2′-Amino-2′-deoxycytidine-triphosphate, 2-thiocytidine-5′-triphosphate, 2-thiouridine-5′-triphosphate, 2′-Fluorothymidine-5′-triphosphate, 2′-0-Methyl-inosine-5′-triphosphate 4-thiouridine-5′-triphosphate, 5-aminoallylcytidine-5′-triphosphate, 5-aminoallyluridine-5′-triphosphate, 5-bromocytidine-5′-triphosphate, 5-bromouridine-5′-triphosphate, 5-Bromo-2′-deoxycytidine-5′-triphosphate, 5-Bromo-2′-deoxyuridine-5′-triphosphate, 5-iodocytidine-5′-triphosphate, 5-Iodo-2′-deoxycytidine-5′-triphosphate, 5-iodouridine-5′-triphosphate, 5-Iodo-2′-deoxyuridine-5′-triphosphate, 5-methylcytidine-5′-triphosphate, 5-methyluridine-5′-triphosphate, 5-Propynyl-2′-deoxycytidine-5′-triphosphate, 5-Propynyl-2′-deoxyuridine-5′-triphosphate, 6-azacytidine-5′-triphosphate, 6-azauridine-5′-triphosphate, 6-chloropurineriboside-5′-triphosphate, 7-deazaadenosine-5′-triphosphate, 7-deazaguanosine-5′-triphosphate, 8-azaadenosine-5′-triphosphate, 8-azidoadenosine-5′-triphosphate, benzimidazole-riboside-5′-triphosphate, N1-methyladenosine-5′-triphosphate, N1-methylguanosine-5′-triphosphate, N6-methyladenosine-5′-triphosphate, 06-methylguanosine-5′-triphosphate, pseudouridine-5′-triphosphate, or puromycin-5′-triphosphate, xanthosine-5′-triphosphate. Particular preference is given to nucleotides for base modifications selected from the group of base-modified nucleotides consisting of 5-methylcytidine-5′-triphosphate, 7-deazaguanosine-5′-triphosphate, 5-bromocytidine-5′-triphosphate, and pseudouridine-5′-triphosphate.

In some embodiments, modified nucleosides include pyridin-4-one ribonucleoside, 5-aza-uridine, 2-thio-5-aza-uridine, 2-thiouridine, 4-thio-pseudouridine, 2-thio-pseudouridine, 5-hydroxyuridine, 3-methyluridine, 5-carboxymethyl-uridine, 1-carboxymethyl-pseudouridine, 5-propynyl-uridine, 1-propynyl-pseudouridine, 5-taurinomethyluridine, 1-taurinomethyl-pseudouridine, 5-taurinomethyl-2-thio-uridine, 1-taurinomethyl-4-thio-uridine, 5-methyl-uridine, 1-methyl-pseudouridine, 4-thio-1-methyl-pseudouridine, 2-thio-1-methyl-pseudouridine, 1-methyl-1-deaza-pseudouridine, 2-thio-1-methyl-1-deaza-pseudouridine, dihydrouridine, dihydropseudouridine, 2-thio-dihydrouridine, 2-thio-dihydropseudouridine, 2-methoxyuridine, 2-methoxy-4-thio-uridine, 4-methoxy-pseudouridine, and 4-methoxy-2-thio-pseudouridine.

In some embodiments, modified nucleosides include 5-aza-cytidine, pseudoisocytidine, 3-methyl-cytidine, N4-acetylcytidine, 5-formylcytidine, N4-methylcytidine, 5-hydroxymethylcytidine, 1-methyl-pseudoisocytidine, pyrrolo-cytidine, pyrrolo-pseudoisocytidine, 2-thio-cytidine, 2-thio-5-methyl-cytidine, 4-thio-pseudoisocytidine, 4-thio-1-methyl-pseudoisocytidine, 4-thio-1-methyl-1-deaza-pseudoisocytidine, 1-methyl-1-deaza-pseudoisocytidine, zebularine, 5-aza-zebularine, 5-methyl-zebularine, 5-aza-2-thio-zebularine, 2-thio-zebularine, 2-methoxy-cytidine, 2-methoxy-5-methyl-cytidine, 4-methoxy-pseudoisocytidine, and 4-methoxy-1-methyl-pseudoisocytidine.

In other embodiments, modified nucleosides include 2-aminopurine, 2,6-diaminopurine, 7-deaza-adenine, 7-deaza-8-aza-adenine, 7-deaza-2-aminopurine, 7-deaza-8-aza-2-aminopurine, 7-deaza-2,6-diaminopurine, 7-deaza-8-aza-2,6-diaminopurine, 1-methyladenosine, N6-methyladenosine, N6-isopentenyladenosine, N6-(cis-hydroxyisopentenyl)adenosine, 2-methylthio-N6-(cis-hydroxyisopentenyl) adenosine, N6-glycinylcarbamoyladenosine, N6-threonylcarbamoyladenosine, 2-methylthio-N6-threonyl carbamoyladenosine, N6,N6-dimethyladenosine, 7-methyladenine, 2-methylthio-adenine, and 2-methoxy-adenine.

In other embodiments, modified nucleosides include inosine, 1-methyl-inosine, wyosine, wybutosine, 7-deaza-guanosine, 7-deaza-8-aza-guanosine, 6-thio-guanosine, 6-thio-7-deaza-guanosine, 6-thio-7-deaza-8-aza-guanosine, 7-methyl-guanosine, 6-thio-7-methyl-guanosine, 7-methylinosine, 6-methoxy-guanosine, 1-methylguanosine, N2-methylguanosine, N2,N2-dimethylguanosine, 8-oxo-guanosine, 7-methyl-8-oxo-guanosine, 1-methyl-6-thio-guanosine, N2-methyl-6-thio-guanosine, and N2,N2-dimethyl-6-thio-guanosine.

In some embodiments, the nucleotide can be modified on the major groove face and can include replacing hydrogen on C-5 of uracil with a methyl group or a halo group. In specific embodiments, a modified nucleoside is 5′-O-(1-thiophosphate)-adenosine, 5′-O-(1-thiophosphate)-cytidine, 5′-O-(1-thiophosphate)-guanosine, 5′-O-(1-thiophosphate)-uridine or 5′-O-(1-thiophosphate)-pseudouridine.

In further specific embodiments, a modified RNA may comprise nucleoside modifications selected from 6-aza-cytidine, 2-thio-cytidine, α-thio-cytidine, Pseudo-iso-cytidine, 5-aminoallyl-uridine, 5-iodo-uridine, N1-methyl-pseudouridine, 5,6-dihydrouridine, α-thio-uridine, 4-thio-uridine, 6-aza-uridine, 5-hydroxy-uridine, deoxy-thymidine, 5-methyl-uridine, Pyrrolo-cytidine, inosine, α-thio-guanosine, 6-methyl-guanosine, 5-methyl-cytdine, 8-oxo-guanosine, 7-deaza-guanosine, N1-methyl-adenosine, 2-amino-6-Chloro-purine, N6-methyl-2-amino-purine, Pseudo-iso-cytidine, 6-Chloro-purine, N6-methyl-adenosine, α-thio-adenosine, 8-azido-adenosine, 7-deaza-adenosine.

Lipid Modification:

According to a further embodiment, a modified RNA as defined herein can contain a lipid modification. Such a lipid-modified RNA typically comprises an RNA as defined herein. Such a lipid-modified RNA as defined herein typically further comprises at least one linker covalently linked with that RNA, and at least one lipid covalently linked with the respective linker. Alternatively, the lipid-modified RNA comprises at least one RNA as defined herein and at least one (bifunctional) lipid covalently linked (without a linker) with that RNA. According to a third alternative, the lipid-modified RNA comprises an RNA molecule as defined herein, at least one linker covalently linked with that RNA, and at least one lipid covalently linked with the respective linker, and also at least one (bifunctional) lipid covalently linked (without a linker) with that RNA. In this context, it is particularly preferred that the lipid modification is present at the terminal ends of a linear RNA sequence.

G/C Content Modification:

According to another embodiment, the RNA of the present invention, preferably an mRNA, may be modified, and thus stabilized, by modifying the guanosine/cytosine (G/C) content of the RNA, preferably of the at least one coding sequence of the RNA of the present invention.

In a particularly preferred embodiment of the present invention, the G/C content of the coding region of the RNA of the present invention is modified, particularly increased, compared to the G/C content of the coding region of the respective wild-type RNA, i.e. the unmodified RNA. The amino acid sequence encoded by the RNA is preferably not modified as compared to the amino acid sequence encoded by the respective wild-type RNA. This modification of the RNA of the present invention is based on the fact that the sequence of any RNA region to be translated is important for efficient translation of that RNA. Thus, the composition of the RNA and the sequence of various nucleotides are important. In particular, sequences having an increased G (guanosine)/C (cytosine) content are more stable than sequences having an increased A (adenosine)/U (uracil) content. According to the invention, the codons of the RNA are therefore varied compared to the respective wild-type RNA, while retaining the translated amino acid sequence, such that they include an increased amount of G/C nucleotides. In respect to the fact that several codons code for one and the same amino acid (so-called degeneration of the genetic code), the most favourable codons for the stability can be determined (so-called alternative codon usage). Depending on the amino acid to be encoded by the RNA, there are various possibilities for modification of the RNA sequence, compared to its wild-type sequence. In the case of amino acids, which are encoded by codons, which contain exclusively G or C nucleotides, no modification of the codon is necessary. Thus, the codons for Pro (CCC or CCG), Arg (CGC or CGG), Ala (GCC or GCG) and Gly (GGC or GGG) require no modification, since no A or U is present. In contrast, codons which contain A and/or U nucleotides can be modified by substitution of other codons, which code for the same amino acids but contain no A and/or U. Examples of these are: the codons for Pro can be modified from CCU or CCA to CCC or CCG; the codons for Arg can be modified from CGU or CGA or AGA or AGG to CGC or CGG; the codons for Ala can be modified from GCU or GCA to GCC or GCG; the codons for Gly can be modified from GGU or GGA to GGC or GGG. In other cases, although A or U nucleotides cannot be eliminated from the codons, it is however possible to decrease the A and U content by using codons which contain a lower content of A and/or U nucleotides. Examples of these are: the codons for Phe can be modified from UUU to UUC; the codons for Leu can be modified from UUA, UUG, CUU or CUA to CUC or CUG; the codons for Ser can be modified from UCU or UCA or AGU to UCC, UCG or AGC; the codon for Tyr can be modified from UAU to UAC; the codon for Cys can be modified from UGU to UGC; the codon for His can be modified from CAU to CAC; the codon for Gln can be modified from CAA to CAG; the codons for Ile can be modified from AUU or AUA to AUC; the codons for Thr can be modified from ACU or ACA to ACC or ACG; the codon for Asn can be modified from AAU to AAC; the codon for Lys can be modified from AAA to AAG; the codons for Val can be modified from GUU or GUA to GUC or GUG; the codon for Asp can be modified from GAU to GAC; the codon for Glu can be modified from GAA to GAG; the stop codon UAA can be modified to UAG or UGA. In the case of the codons for Met (AUG) and Trp (UGG), on the other hand, there is no possibility of sequence modification. The substitutions listed above can be used either individually or in all possible combinations to increase the G/C content of the at least one mRNA of the composition of the present invention compared to its particular wild-type mRNA (i.e. the original sequence). Thus, for example, all codons for Thr occurring in the wild-type sequence can be modified to ACC (or ACG). Preferably, however, for example, combinations of the above substitution possibilities are used:

substitution of all codons coding for Thr in the original sequence (wild-type mRNA) to ACC (or ACG) and

substitution of all codons originally coding for Ser to UCC (or UCG or AGC); substitution of all codons coding for Ile in the original sequence to AUC and

substitution of all codons originally coding for Lys to AAG and

substitution of all codons originally coding for Tyr to UAC; substitution of all codons coding for Val in the original sequence to GUC (or GUG) and

substitution of all codons originally coding for Glu to GAG and

substitution of all codons originally coding for Ala to GCC (or GCG) and

substitution of all codons originally coding for Arg to CGC (or CGG); substitution of all codons coding for Val in the original sequence to GUC (or GUG) and

substitution of all codons originally coding for Glu to GAG and

substitution of all codons originally coding for Ala to GCC (or GCG) and

substitution of all codons originally coding for Gly to GGC (or GGG) and

substitution of all codons originally coding for Asn to AAC; substitution of all codons coding for Val in the original sequence to GUC (or GUG) and

substitution of all codons originally coding for Phe to UUC and

substitution of all codons originally coding for Cys to UGC and

substitution of all codons originally coding for Leu to CUG (or CUC) and

substitution of all codons originally coding for Gln to CAG and

substitution of all codons originally coding for Pro to CCC (or CCG); etc.

Preferably, the G/C content of the coding region of the RNA of the present invention is increased by at least 7%, more preferably by at least 15%, particularly preferably by at least 20%, compared to the G/C content of the coding region of the wild-type RNA, which codes for an antibody as defined herein or a fragment or variant thereof. According to a specific embodiment at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, more preferably at least 70%, even more preferably at least 80% and most preferably at least 90%, 95% or even 100% of the substitutable codons in the region coding for an antibody as defined herein or a fragment or variant thereof or the whole sequence of the wild type RNA sequence are substituted, thereby increasing the GC/content of said sequence. In this context, it is particularly preferable to increase the G/C content of the RNA of the present invention, preferably of the at least one coding region of the RNA according to the invention, to the maximum (i.e. 100% of the substitutable codons) as compared to the wild-type sequence. According to the invention, a further preferred modification of the RNA of the present invention is based on the finding that the translation efficiency is also determined by a different frequency in the occurrence of tRNAs in cells. Thus, if so-called “rare codons” are present in the RNA of the present invention to an increased extent, the corresponding modified RNA sequence is translated to a significantly poorer degree than in the case where codons coding for relatively “frequent” tRNAs are present. According to the invention, in the modified RNA of the present invention, the region which codes for an antibody as defined herein or a fragment or variant thereof is modified compared to the corresponding region of the wild-type RNA such that at least one codon of the wild-type sequence, which codes for a tRNA which is relatively rare in the cell, is exchanged for a codon, which codes for a tRNA which is relatively frequent in the cell and carries the same amino acid as the relatively rare tRNA. By this modification, the sequences of the RNA of the present invention is modified such that codons for which frequently occurring tRNAs are available are inserted. In other words, according to the invention, by this modification all codons of the wild-type sequence, which code for a tRNA which is relatively rare in the cell, can in each case be exchanged for a codon, which codes for a tRNA which is relatively frequent in the cell and which, in each case, carries the same amino acid as the relatively rare tRNA. Which tRNAs occur relatively frequently in the cell and which, in contrast, occur relatively rarely is known to a person skilled in the art; cf. e.g. Akashi, Curr. Opin. Genet. Dev. 2001, 11(6): 660-666. The codons, which use for the particular amino acid the tRNA which occurs the most frequently, e.g. the Gly codon, which uses the tRNA, which occurs the most frequently in the (human) cell, are particularly preferred. According to the invention, it is particularly preferable to link the sequential G/C content which is increased, in particular maximized, in the modified RNA of the present invention, with the “frequent” codons without modifying the amino acid sequence of the protein encoded by the coding region of the RNA. This preferred embodiment allows provision of a particularly efficiently translated and stabilized (modified) RNA of the present invention. The determination of a modified RNA of the present invention as described above (increased G/C content; exchange of tRNAs) can be carried out using the computer program explained in WO 02/098443—the disclosure content of which is included in its full scope in the present invention. Using this computer program, the nucleotide sequence of any desired RNA can be modified with the aid of the genetic code or the degenerative nature thereof such that a maximum G/C content results, in combination with the use of codons which code for tRNAs occurring as frequently as possible in the cell, the amino acid sequence coded by the modified RNA preferably not being modified compared to the non-modified sequence. Alternatively, it is also possible to modify only the G/C content or only the codon usage compared to the original sequence. The source code in Visual Basic 6.0 (development environment used: Microsoft Visual Studio Enterprise 6.0 with Servicepack 3) is also described in WO 02/098443. In a further preferred embodiment of the present invention, the A/U content in the environment of the ribosome binding site of the RNA of the present invention is increased compared to the A/U content in the environment of the ribosome binding site of its respective wild-type mRNA. This modification (an increased A/U content around the ribosome binding site) increases the efficiency of ribosome binding to the RNA. An effective binding of the ribosomes to the ribosome binding site (Kozak sequence: SEQ ID NO: 61159 (DNA) or SEQ ID NO:61160 (RNA), respectively; the AUG forms the start codon) in turn has the effect of an efficient translation of the RNA. According to a further embodiment of the present invention, the RNA of the present invention may be modified with respect to potentially destabilizing sequence elements. Particularly, the coding region and/or the 5′ and/or 3′ untranslated region of this RNA may be modified compared to the respective wild-type RNA such that it contains no destabilizing sequence elements, the encoded amino acid sequence of the modified RNA preferably not being modified compared to its respective wild-type RNA. It is known that, for example in sequences of eukaryotic RNAs, destabilizing sequence elements (DSE) occur, to which signal proteins bind and regulate enzymatic degradation of RNA in vivo. For further stabilization of the modified RNA, optionally in the region which encodes an antibody as defined herein or a fragment or variant thereof, one or more such modifications compared to the corresponding region of the wild-type RNA can therefore be carried out, so that no or substantially no destabilizing sequence elements are contained there. According to the invention, DSE present in the untranslated regions (3′- and/or 5′-UTR) can also be eliminated from the RNA of the present invention by such modifications. Such destabilizing sequences are e.g. AU-rich sequences (AURES), which occur in 3′-UTR sections of numerous unstable RNAs (Caput et al., Proc. Natl. Acad. Sci. USA 1986, 83: 1670 to 1674). The RNA of the present invention is therefore preferably modified compared to the respective wild-type RNA such that the RNA of the present invention contains no such destabilizing sequences. This also applies to those sequence motifs which are recognized by possible endonucleases, e.g. the sequence GAACAAG, which is contained in the 3′-UTR segment of the gene encoding the transferrin receptor (Binder et al., EMBO J. 1994, 13: 1969 to 1980). These sequence motifs are also preferably removed in the RNA of the present invention.

GC Optimized Sequences:

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-15284, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174, 61175, 61209-61211, 61215-61217, 61239-61242, 61248-61250, 61272-61275, 61282-61284, 61306-61309, 61313, 61321, 61325, 61333, 61336, 61339, 61347, 61350, 61358, 61360, 61363, 61371, 61374, 61382, 61386, 61387, 61402-61404, 61416, 61419, 61427, 61430, 61438, 61442, 61443, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501, 61502, 61517-61519, 61523, 61524, 61539-61541, 61545, 61546, 61561-61563, 61566, 61574, 61577, 61585, 61589, 61590, 61604, 61607, 61610, 61613, 61615, 61620, 61621, 61636, 61637, 61641, 61642, 61646, 61647, 61662-61664, 61668, 61676, 61679, 61687, 61690, 61698, 61701, 61709, 61712, 61720, 61723, 61731, and 61733; or a fragment or variant of any one of said nucleic acid sequences.

It is also preferred that the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-15284, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174, 61175, 61209-61211, 61215-61217, 61239-61242, 61248-61250, 61272-61275, 61282-61284, 61306-61309, 61313, 61321, 61325, 61333, 61336, 61339, 61347, 61350, 61358, 61360, 61363, 61371, 61374, 61382, 61386, 61387, 61402-61404, 61416, 61419, 61427, 61430, 61438, 61442, 61443, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501, 61502, 61517-61519, 61523, 61524, 61539-61541, 61545, 61546, 61561-61563, 61566, 61574, 61577, 61585, 61589, 61590, 61604, 61607, 61610, 61613, 61615, 61620, 61621, 61636, 61637, 61641, 61642, 61646, 61647, 61662-61664, 61668, 61676, 61679, 61687, 61690, 61698, 61701, 61709, 61712, 61720, 61723, 61731, and 61733; or a fragment or variant of any one of said nucleic acid sequences.

It is also preferred that the RNA comprises at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 38211-45852, 61227-1229, 61260-61262, 61294-61296, 61317, 61329, 61343, 61354, 61367, 61378, 61394, 61395, 61423, 61434, 61450, 61451, 61509, 61510, 61531, 61532, 61553, 61554, 61570, 61581, 61597, 61598, 61628, 61629, 61654, 61655, 61672, 61683, 61694, 61705, 61716, and 61727; or a fragment or variant of any one of said nucleic acid sequences.

Preferably, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 38211-45852, 61227-1229, 61260-61262, 61294-61296, 61317, 61329, 61343, 61354, 61367, 61378, 61394, 61395, 61423, 61434, 61450, 61451, 61509, 61510, 61531, 61532, 61553, 61554, 61570, 61581, 61597, 61598, 61628, 61629, 61654, 61655, 61672, 61683, 61694, 61705, 61716, and 61727; or a fragment or variant of any one of said nucleic acid sequences.

It is also preferred that the RNA comprises at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 45853-53494, 61230-61232, 61263-61265, 61297-61299, 61318, 61330, 61344, 61355, 61368, 61379, 61396, 61397, 61424, 61435, 61452, 61453, 61511, 61512, 61533, 61534, 61555, 61556, 61571, 61582, 61599, 61600, 61630, 61631, 61656, 61657, 61673, 61684, 61695, 61706, 61717, 61728; or a fragment or variant of any one of said nucleic acid sequences.

Preferably, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, ₄₀%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 45853-53494, 61230-61232, 61263-61265, 61297-61299, 61318, 61330, 61344, 61355, 61368, 61379, 61396, 61397, 61424, 61435, 61452, 61453, 61511, 61512, 61533, 61534, 61555, 61556, 61571, 61582, 61599, 61600, 61630, 61631, 61656, 61657, 61673, 61684, 61695, 61706, 61717, 61728; or a fragment or variant of any one of said nucleic acid sequences.

It is also preferred that the RNA comprises at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 53495-61136, 61233-61235, 61266-61268, 61300-61302, 61319, 61331, 61345, 61356, 61369, 61380, 61398, 61399, 61425, 61436, 61454, 61455, 61513, 61514, 61535, 61536, 61557, 61558, 61572, 61583, 61601, 61602, 61632, 61633, 61658, 61659, 61674, 61685, 61696, 61707, 61718, and 61729; or a fragment or variant of any one of said nucleic acid sequences.

Preferably, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 53495-61136, 61233-61235, 61266-61268, 61300-61302, 61319, 61331, 61345, 61356, 61369, 61380, 61398, 61399, 61425, 61436, 61454, 61455, 61513, 61514, 61535, 61536, 61557, 61558, 61572, 61583, 61601, 61602, 61632, 61633, 61658, 61659, 61674, 61685, 61696, 61707, 61718, and 61729; or a fragment or variant of any one of said nucleic acid sequences.

Sequences Adapted to Human Codon Usage:

According to the invention, a further preferred modification of the RNA of the present invention is based on the finding that codons encoding the same amino acid typically occur at different frequencies. According to the invention, in the modified RNA of the present invention, the coding sequence (coding region) as defined herein is preferably modified compared to the corresponding region of the respective wild-type RNA such that the frequency of the codons encoding the same amino acid corresponds to the naturally occurring frequency of that codon according to the human codon usage as e.g. shown in Table 10.

For example, in the case of the amino acid alanine (Ala) present in an amino acid sequence encoded by the at least one coding sequence of the RNA according to the invention, the wild type coding sequence is preferably adapted in a way that the codon “GCC” is used with a frequency of 0.40, the codon “GOT” is used with a frequency of 0.28, the codon “GCA” is used with a frequency of 0.22 and the codon “GCG” is used with a frequency of 0.10 etc. (see Table 10).

TABLE 10 Human codon usage table Aminoacid codon fraction /1000 Aminoacid codon fraction /1000 Ala GCG 0.10 7.4 Pro CCG 0.11 6.9 Ala GCA 0.22 15.8 Pro CCA 0.27 16.9 Ala GCT 0.28 18.5 Pro CCT 0.29 17.5 Ala GCC* 0.40 27.7 Pro CCC* 0.33 19.8 Cys TGT 0.42 10.6 Gln CAG* 0.73 34.2 Cys TGC* 0.58 12.6 Gln CAA 0.27 12.3 Asp GAT 0.44 21.8 Arg AGG 0.22 12.0 Asp GAC* 0.56 25.1 Arg AGA* 0.21 12.1 Glu GAG* 0.59 39.6 Arg CGG 0.19 11.4 Glu GAA 0.41 29.0 Arg CGA 0.10 6.2 Phe TTT 0.43 17.6 Arg CGT 0.09 4.5 Phe TTC* 0.57 20.3 Arg CGC 0.19 10.4 Gly GGG 0.23 16.5 Ser AGT 0.14 12.1 Gly GGA 0.26 16.5 Ser AGC* 0.25 19.5 Gly GGT 0.18 10.8 Ser TCG 0.06 4.4 Gly GGC* 0.33 22.2 Ser TCA 0.15 12.2 His CAT 0.41 10.9 Ser TCT 0.18 15.2 His CAC* 0.59 15.1 Ser TCC 0.23 17.7 Ile ATA 0.14 7.5 Thr ACG 0.12 6.1 Ile ATT 0.35 16.0 Thr ACA 0.27 15.1 Ile ATC* 0.52 20.8 Thr ACT 0.23 13.1 Lys AAG* 0.60 31.9 Thr ACC* 0.38 18.9 Lys AAA 0.40 24.4 Val GTG* 0.48 28.1 Leu TTG 0.12 12.9 Val GTA 0.10 7.1 Leu TTA 0.06 7.7 Val GTT 0.17 11.0 Leu CTG* 0.43 39.6 Val GTC 0.25 14.5 Leu CTA 0.07 7.2 Trp TGG* 1 13.2 Leu CTT 0.12 13.2 Tyr TAT 0.42 12.2 Leu CTC 0.20 19.6 Tyr TAC* 0.58 15.3 Met ATG* 1 22.0 Stop TGA* 0.61 1.6 Asn AAT 0.44 17.0 Stop TAG 0.17 0.8 Asn AAC* 0.56 19.1 Stop TM 0.22 1.0 *most frequent codon

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 22927-30568, 61221-61223, 61254-61256, 61288-61290, 61315, 61327, 61341, 61352, 61365, 61376, 61390, 61391, 61421, 61432, 61446, 61447, 61505, 61506, 61527, 61528, 61549, 61550, 61568, 61579, 61593, 61594, 61624, 61625, 61650, 61651, 61670, 61681, 61692, 61703, 61714, and 61725; or a fragment or variant of any one of said nucleic acid sequences.

According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 22927-30568, 61221-61223, 61254-61256, 61288-61290, 61315, 61327, 61341, 61352, 61365, 61376, 61390, 61391, 61421, 61432, 61446, 61447, 61505, 61506, 61527, 61528, 61549, 61550, 61568, 61579, 61593, 61594, 61624, 61625, 61650, 61651, 61670, 61681, 61692, 61703, 61714, and 61725; ora fragment or variant of any one of said nucleic acid sequences.

Codon-Optimized Sequences:

As described above it is preferred according to the invention, that all codons of the wild-type sequence which code for a tRNA, which is relatively rare in the cell, are exchanged for a codon which codes for a tRNA, which is relatively frequent in the cell and which, in each case, carries the same amino acid as the relatively rare tRNA. Therefore it is particularly preferred that the most frequent codons are used for each encoded amino acid (see Table 2, most frequent codons are marked with asterisks). Such an optimization procedure increases the codon adaptation index (CAI) and ultimately maximises the CAI. In the context of the invention, sequences with increased or maximized CAI are typically referred to as “codon-optimized” sequences and/or CAI increased and/or maximized sequences. According to a preferred embodiment, the RNA of the present invention comprises at least one coding sequence, wherein the coding sequence is codon-optimized as described herein. More preferably, the codon adaptation index (CAI) of the at least one coding sequence is at least 0.5, at least 0.8, at least 0.9 or at least 0.95. Most preferably, the codon adaptation index (CAI) of the at least one coding sequence is 1.

For example, in the case of the amino acid alanine (Ala) present in the amino acid sequence encoded by the at least one coding sequence of the RNA according to the invention, the wild type coding sequence is adapted in a way that the most frequent human codon “GCC” is always used for said amino acid, or for the amino acid Cysteine (Cys), the wild type sequence is adapted in a way that the most frequent human codon “TGC” is always used for said amino acid etc.

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 30569-38210, 61224-61226, 61257-61259, 61291-61293, 61316, 61328, 61342, 61353, 61366, 61377, 61392, 61393, 61422, 61433, 61448, 61449, 61507, 61508, 61529, 61530, 61551, 61552, 61569, 61580, 61595, 61596, 61626, 61627, 61652, 61653, 61671, 61682, 61693, 61704, 61715, and 61726; or a fragment or variant of any one of said nucleic acid sequences.

According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 30569-38210, 61224-61226, 61257-61259, 61291-61293, 61316, 61328, 61342, 61353, 61366, 61377, 61392, 61393, 61422, 61433, 61448, 61449, 61507, 61508, 61529, 61530, 61551, 61552, 61569, 61580, 61595, 61596, 61626, 61627, 61652, 61653, 61671, 61682, 61693, 61704, 61715, and 61726; or a fragment or variant of any one of said nucleic acid sequences.

C-Optimized Sequences:

According to another embodiment, the RNA of the composition of the present invention may be modified by modifying, preferably increasing, the cytosine (C) content of the RNA, preferably of the coding region of the aRNA.

In a particularly preferred embodiment of the present invention, the C content of the coding region of the RNA of the present invention is modified, preferably increased, compared to the C content of the coding region of the respective wild-type RNA, i.e. the unmodified RNA. The amino acid sequence encoded by the at least one coding sequence of the RNA of the present invention is preferably not modified as compared to the amino acid sequence encoded by the respective wild-type mRNA.

In a preferred embodiment of the present invention, the modified RNA is modified such that at least 10%, 20%, 30%, 40%, 50%, 60%, 70% or 80%, or at least 90% of the theoretically possible maximum cytosine-content or even a maximum cytosine-content is achieved.

In further preferred embodiments, at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% or even 100% of the codons of the target RNA wild type sequence, which are “cytosine content optimizable” are replaced by codons having a higher cytosine-content than the ones present in the wild type sequence.

In a further preferred embodiment, some of the codons of the wild type coding sequence may additionally be modified such that a codon for a relatively rare tRNA in the cell is exchanged by a codon for a relatively frequent tRNA in the cell, provided that the substituted codon for a relatively frequent tRNA carries the same amino acid as the relatively rare tRNA of the original wild type codon. Preferably, all of the codons for a relatively rare tRNA are replaced by a codon for a relatively frequent tRNA in the cell, except codons encoding amino acids, which are exclusively encoded by codons not containing any cytosine, or except for glutamine (Gln), which is encoded by two codons each containing the same number of cytosines.

In a further preferred embodiment of the present invention, the modified target RNA is modified such that at least 80%, or at least 90% of the theoretically possible maximum cytosine-content or even a maximum cytosine-content is achieved by means of codons, which code for relatively frequent tRNAs in the cell, wherein the amino acid sequence remains unchanged.

Due to the naturally occurring degeneracy of the genetic code, more than one codon may encode a particular amino acid. Accordingly, 18 out of 20 naturally occurring amino acids are encoded by more than one codon (with Tryp and Met being an exception), e.g. by 2 codons (e.g. Cys, Asp, Glu), by three codons (e.g. Ile), by 4 codons (e.g. Al, Gly, Pro) or by 6 codons (e.g. Leu, Arg, Ser). However, not all codons encoding the same amino acid are utilized with the same frequency under in vivo conditions. Depending on each single organism, a typical codon usage profile is established.

The term ‘cytosine content-optimizable codon’ as used within the context of the present invention refers to codons, which exhibit a lower content of cytosines than other codons encoding the same amino acid. Accordingly, any wild type codon, which may be replaced by another codon encoding the same amino acid and exhibiting a higher number of cytosines within that codon, is considered to be cytosine-optimizable (C-optimizable). Any such substitution of a C-optimizable wild type codon by the specific C-optimized codon within a wild type coding region increases its overall C-content and reflects a C-enriched modified mRNA sequence. According to a preferred embodiment, the RNA of the present invention, preferably the at least one coding sequence of the RNA of the present invention comprises or consists of a C-maximized RNA sequence containing C-optimized codons for all potentially C-optimizable codons. Accordingly, 100% or all of the theoretically replaceable C-optimizable codons are preferably replaced by C-optimized codons over the entire length of the coding region.

In this context, cytosine-content optimizable codons are codons, which contain a lower number of cytosines than other codons coding for the same amino acid.

Any of the codons GCG, GCA, GCU codes for the amino acid Ala, which may be exchanged by the codon GCC encoding the same amino acid, and/or

the codon UGU that codes for Cys may be exchanged by the codon UGC encoding the same amino acid, and/or

the codon GAU which codes for Asp may be exchanged by the codon GAC encoding the same amino acid, and/or

the codon that UUU that codes for Phe may be exchanged for the codon UUC encoding the same amino acid, and/or

any of the codons GGG, GGA, GGU that code Gly may be exchanged by the codon GGC encoding the same amino acid, and/or

the codon CAU that codes for His may be exchanged by the codon CAC encoding the same amino acid, and/or

any of the codons AUA, AUU that code for Ile may be exchanged by the codon AUC, and/or

any of the codons UUG, UUA, CUG, CUA, CUU coding for Leu may be exchanged by the codon CUC encoding the same amino acid, and/or

the codon AAU that codes for Asn may be exchanged by the codon AAC encoding the same amino acid, and/or

any of the codons CCG, CCA, CCU coding for Pro may be exchanged by the codon CCC encoding the same amino acid, and/or

any of the codons AGG, AGA, CGG, CGA, CGU coding for Arg may be exchanged by the codon CGC encoding the same amino acid, and/or

any of the codons AGU, AGC, UCG, UCA, UCU coding for Ser may be exchanged by the codon UCC encoding the same amino acid, and/or

any of the codons ACG, ACA, ACU coding for Thr may be exchanged by the codon ACC encoding the same amino acid, and/or

any of the codons GUG, GUA, GUU coding for Val may be exchanged by the codon GUC encoding the same amino acid, and/or

the codon UAU coding for Tyr may be exchanged by the codon UAC encoding the same amino acid.

In any of the above instances, the number of cytosines is increased by 1 per exchanged codon. Exchange of all non C-optimized codons (corresponding to C-optimizable codons) of the coding region results in a C-maximized coding sequence. In the context of the invention, at least 70%, preferably at least 80%, more preferably at least 90%, of the non C-optimized codons within the at least one coding region of the RNA according to the invention are replaced by C-optimized codons.

It may be preferred that for some amino acids the percentage of C-optimizable codons replaced by C-optimized codons is less than 70%, while for other amino acids the percentage of replaced codons is higher than 70% to meet the overall percentage of C-optimization of at least 70% of all C-optimizable wild type codons of the coding region.

Preferably, in a C-optimized RNA of the invention, at least 50% of the C-optimizable wild type codons for any given amino acid are replaced by C-optimized codons, e.g. any modified C-enriched RNA preferably contains at least 50% C-optimized codons at C-optimizable wild type codon positions encoding any one of the above mentioned amino acids Ala, Cys, Asp, Phe, Gly, His, Ile, Leu, Asn, Pro, Arg, Ser, Thr, Val and Tyr, preferably at least 60%.

In this context codons encoding amino acids, which are not cytosine content-optimizable and which are, however, encoded by at least two codons, may be used without any further selection process. However, the codon of the wild type sequence that codes for a relatively rare tRNA in the cell, e.g. a human cell, may be exchanged for a codon that codes for a relatively frequent tRNA in the cell, wherein both code for the same amino acid. Accordingly, the relatively rare codon GAA coding for Glu may be exchanged by the relative frequent codon GAG coding for the same amino acid, and/or

the relatively rare codon AAA coding for Lys may be exchanged by the relative frequent codon AAG coding for the same amino acid, and/or

the relatively rare codon CAA coding for Gln may be exchanged for the relative frequent codon CAG encoding the same amino acid.

In this context, the amino acids Met (AUG) and Trp (UGG), which are encoded by only one codon each, remain unchanged. Stop codons are not cytosine-content optimized, however, the relatively rare stop codons amber, ochre (UAA, UAG) may be exchanged by the relatively frequent stop codon opal (UGA).

The single substitutions listed above may be used individually as well as in all possible combinations in order to optimize the cytosine-content of the modified RNA compared to the wild type mRNA sequence.

Accordingly, the at least one coding sequence as defined herein may be changed compared to the coding region of the respective wild type RNA in such a way that an amino acid encoded by at least two or more codons, of which one comprises one additional cytosine, such a codon may be exchanged by the C-optimized codon comprising one additional cytosine, wherein the amino acid is preferably unaltered compared to the wild type sequence.

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 15285-22926, 61218-61220, 61251-61253, 61285-61287, 61314, 61326, 61340, 61351, 61364, 61375, 61388, 61389, 61420, 61431, 61444, 61445, 61503, 61504, 61525, 61526, 61547, 61548, 61567, 61578, 61591, 61592, 61622, 61623, 61648, 61649, 61669, 61680, 61691, 61702, 61713, and 61724; or a fragment or variant of any one of said nucleic acid sequences.

According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 15285-22926, 61218-61220, 61251-61253, 61285-61287, 61314, 61326, 61340, 61351, 61364, 61375, 61388, 61389, 61420, 61431, 61444, 61445, 61503, 61504, 61525, 61526, 61547, 61548, 61567, 61578, 61591, 61592, 61622, 61623, 61648, 61649, 61669, 61680, 61691, 61702, 61713, and 61724; or a fragment or variant of any one of said nucleic acid sequences.

According to a particularly preferred embodiment, the invention provides an RNA, preferably an mRNA, comprising at least one coding sequence as defined herein, wherein the G/C content of the at least one coding sequence of the RNA is increased compared to the G/C content of the corresponding coding sequence of the corresponding wild-type RNA, and/or

wherein the C content of the at least one coding sequence of the RNA is increased compared to the C content of the corresponding coding sequence of the corresponding wild-type RNA, and/or wherein the codons in the at least one coding sequence of the RNA are adapted to human codon usage, wherein the codon adaptation index (CAI) is preferably increased or maximised in the at least one coding sequence of the RNA,

and wherein the amino acid sequence encoded by the RNA is preferably not being modified compared to the amino acid sequence encoded by the corresponding wild-type RNA.

Accordingly, the nucleic acid sequence, which is comprised by the at least one coding sequence of the inventive RNA, is preferably selected from the group consisting of SEQ ID NO: 7643-61136, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174, 61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

It is also preferred that the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-61136, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174, 61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

According to another preferred embodiment of the invention, a modified RNA as defined herein, can be modified by the addition of a so-called ‘5’ cap' structure, which preferably stabilizes the RNA as described herein. A 5′-cap is an entity, typically a modified nucleotide entity, which generally “caps” the 5′-end of a mature mRNA. A 5′-cap may typically be formed by a modified nucleotide, particularly by a derivative of a guanine nucleotide. Preferably, the 5′-cap is linked to the 5′-terminus via a 5′-5′-triphosphate linkage. A 5′-cap may be methylated, e.g. m7GpppN, wherein N is the terminal 5′ nucleotide of the nucleic acid carrying the 5′-cap, typically the 5′-end of an mRNA. m7GpppN is the 5′-cap structure, which naturally occurs in mRNA transcribed by polymerase II and is therefore preferably not considered as modification comprised in a modified mRNA in this context. Accordingly, a modified RNA of the present invention may comprise a m7GpppN as 5′-cap, but additionally the modified RNA typically comprises at least one further modification as defined herein.

Further examples of 5′cap structures include glyceryl, inverted deoxy abasic residue (moiety), 4′,5′ methylene nucleotide, 1-(beta-D-erythrofuranosyl) nucleotide, 4′-thio nucleotide, carbocyclic nucleotide, 1,5-anhydrohexitol nucleotide, L-nucleotides, alpha-nucleotide, modified base nucleotide, threo-pentofuranosyl nucleotide, acyclic 3′,4′-seco nucleotide, acyclic 3,4-dihydroxybutyl nucleotide, acyclic 3,5 dihydroxypentyl nucleotide, 3′-3′-inverted nucleotide moiety, 3′-3′-inverted abasic moiety, 3′-2′-inverted nucleotide moiety, 3′-2′-inverted abasic moiety, 1,4-butanediol phosphate, 3′-phosphoramidate, hexylphosphate, am inohexyl phosphate, 3′-phosphate, 3′phosphorothioate, phosphorodithioate, or bridging or non-bridging methylphosphonate moiety. These modified 5′-cap structures are regarded as at least one modification in this context.

Particularly preferred modified 5′-cap structures are cap1 (methylation of the ribose of the adjacent nucleotide of m7G), cap2 (additional methylation of the ribose of the 2nd nucleotide downstream of the m7G), cap3 (additional methylation of the ribose of the 3rd nucleotide downstream of the m7G), cap4 (methylation of the ribose of the 4th nucleotide downstream of the m7G), ARCA (anti-reverse cap analogue, modified ARCA (e.g. phosphothioate modified ARCA), inosine, N1-methyl-guanosine, 2′-fluoro-guanosine, 7-deaza-guanosine, 8-oxo-guanosine, 2-amino-guanosine, LNA-guanosine, and 2-azido-guanosine. Accordingly, the RNA according to the invention preferably comprises a 5′-cap structure.

In a preferred embodiment, the RNA according to the invention comprises at least one 5′- or 3′-UTR element. In this context, an UTR element comprises or consists of a nucleic acid sequence, which is derived from the 5′- or 3′-UTR of any naturally occurring gene or which is derived from a fragment, a homolog or a variant of the 5′- or 3′-UTR of a gene. Preferably, the 5′- or 3′-UTR element used according to the present invention is heterologous to the at least one coding sequence of the RNA of the invention. Even if 5′- or 3′-UTR elements derived from naturally occurring genes are preferred, also synthetically engineered UTR elements may be used in the context of the present invention.

The term ‘3′UTR element’ typically refers to a nucleic acid sequence, which comprises or consists of a nucleic acid sequence that is derived from a 3′UTR or from a variant of a 3′UTR. A 3′UTR element in the sense of the present invention may represent the 3′UTR of an RNA, preferably an mRNA. Thus, in the sense of the present invention, preferably, a 3′UTR element may be the 3′UTR of an RNA, preferably of an mRNA, or it may be the transcription template for a 3′UTR of an RNA. Thus, a 3′UTR element preferably is a nucleic acid sequence which corresponds to the 3′UTR of an RNA, preferably to the 3′UTR of an mRNA, such as an mRNA obtained by transcription of a genetically engineered vector construct. Preferably, the 3′UTR element fulfils the function of a 3′UTR or encodes a sequence which fulfils the function of a 3′UTR.

According to a preferred embodiment, the RNA, preferably an mRNA, according to the invention comprises a 5′-cap structure and/or at least one 3′-untranslated region element (3′-UTR element), preferably as defined herein. More preferably, the RNA further comprises a 5′-UTR element as defined herein.

According to a further preferred embodiment, the RNA of the present invention may contain a poly-A tail on the 3′ terminus of typically about 10 to 200 adenosine nucleotides, preferably about 10 to 100 adenosine nucleotides, more preferably about 40 to 80 adenosine nucleotides or even more preferably about 50 to 70 adenosine nucleotides.

Preferably, the poly(A) sequence in the RNA of the present invention is derived from a DNA template by RNA in vitro transcription. Alternatively, the poly(A) sequence may also be obtained in vitro by common methods of chemical-synthesis without being necessarily transcribed from a DNA-progenitor. Moreover, poly(A) sequences, or poly(A) tails may be generated by enzymatic polyadenylation of the RNA according to the present invention using commercially available polyadenylation kits and corresponding protocols known in the art.

Alternatively, the RNA as described herein optionally comprises a polyadenylation signal, which is defined herein as a signal, which conveys polyadenylation to a (transcribed) RNA by specific protein factors (e.g. cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors I and II (CF I and CF II), poly(A) polymerase (PAP)). In this context, a consensus polyadenylation signal is preferred comprising the NN(U/T)ANA consensus sequence. In a particularly preferred aspect, the polyadenylation signal comprises one of the following sequences: AA(U/T)AAA or A(U/T)(U/T)AAA (wherein uridine is usually present in RNA and thymidine is usually present in DNA).

According to a further preferred embodiment, the RNA of the present invention may contain a poly(C) tail on the 3′ terminus of typically about 10 to 200 cytosine nucleotides, preferably about 10 to 100 cytosine nucleotides, more preferably about 20 to 70 cytosine nucleotides or even more preferably about 20 to 60 or even 10 to 40 cytosine nucleotides.

In a further preferred embodiment, the RNA according to the invention further comprises at least one 3′UTR element. Preferably, the at least one 3′UTR element comprises or consists of a nucleic acid sequence derived from the 3′UTR of a chordate gene, preferably a vertebrate gene, more preferably a mammalian gene, most preferably a human gene, or from a variant of the 3′UTR of a chordate gene, preferably a vertebrate gene, more preferably a mammalian gene, most preferably a human gene.

Preferably, the RNA of the present invention comprises a 3′UTR element, which may be derivable from a gene that relates to an mRNA with an enhanced half-life (that provides a stable mRNA), for example a 3′UTR element as defined and described below. Preferably, the 3′-UTR element is a nucleic acid sequence derived from a 3′-UTR of a gene, which preferably encodes a stable mRNA, or from a homolog, a fragment or a variant of said gene

In a particularly preferred embodiment, the 3′UTR element comprises or consists of a nucleic acid sequence, which is derived from a 3′UTR of a gene selected from the group consisting of an albumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, such as a collagen alpha 1(1) gene, or from a variant of a 3′UTR of a gene selected from the group consisting of an albumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, such as a collagen alpha 1(I) gene according to SEQ ID NOs: 1369-1390 of the patent application WO2013/143700, whose disclosure is incorporated herein by reference, or from a homolog, a fragment or a variant thereof. In a particularly preferred embodiment, the 3′UTR element comprises or consists of a nucleic acid sequence which is derived from a 3′UTR of an albumin gene, preferably a vertebrate albumin gene, more preferably a mammalian albumin gene, most preferably a human albumin gene according to SEQ ID NO: 61151 or the corresponding RNA sequence SEQ ID NO: 61152.

In this context it is particularly preferred that the RNA according to the invention comprises a 3′-UTR element comprising a corresponding RNA sequence derived from the nucleic acids according to SEQ ID NOs: 1369-1390 of the patent application WO2013/143700 or a fragment, homolog or variant thereof.

Most preferably the 3′-UTR element comprises the nucleic acid sequence derived from a fragment of the human albumin gene according to SEQ ID NOs: 61153 or 61155.

In this context, it is particularly preferred that the 3′-UTR element of the RNA according to the present invention comprises or consists of a corresponding RNA sequence of the nucleic acid sequence according to SEQ ID NO: 61153 or 61155 as shown in SEQ ID NOs: 61154 or 61156.

In another particularly preferred embodiment, the 3′UTR element comprises or consists of a nucleic acid sequence which is derived from a 3′UTR of an α-globin gene, preferably a vertebrate α- or β-globin gene, more preferably a mammalian α- or β-globin gene, most preferably a human α- or β-globin gene according to SEQ ID NOs: 61143, 61145 or 61147 or the corresponding RNA sequences SEQ ID NOs: 61144, 61146 or 61148.

For example, the 3′UTR element may comprise or consist of the center, α-complex-binding portion of the 3′UTR of an α-globin gene, such as of a human α-globin gene, or a homolog, a fragment, or a variant of an α-globin gene, preferably according to SEQ ID NO: 61149:

Center, α-complex-binding portion of the 3′UTR of an α-globin gene (also named herein as “muag”) GCCCGATGGGCCTCCCAACGGGCCCTCCTCCCCTCCTTGCACCG (SEQ ID NO: 61149 corresponding to SEQ ID NO: 1393 of the patent application WO2013/143700).

In this context it is particularly preferred that the 3′-UTR element of the RNA according to the invention comprises or consists of a corresponding RNA sequence of the nucleic acid sequence according to SEQ ID NO: 61149 as shown in SEQ ID NO: 61150, or a homolog, a fragment or variant thereof.

The term ‘a nucleic acid sequence which is derived from the 3′UTR of a [ . . . ] gene’ preferably refers to a nucleic acid sequence which is based on the 3′UTR sequence of a [ . . . ] gene or on a part thereof, such as on the 3′UTR of an albumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, or a collagen alpha gene, such as a collagen alpha 1(I) gene, preferably of an albumin gene or on a part thereof. This term includes sequences corresponding to the entire 3′UTR sequence, i.e. the full length 3′UTR sequence of a gene, and sequences corresponding to a fragment of the 3′UTR sequence of a gene, such as an albumin gene, α-globin gene, β-globin gene, tyrosine hydroxylase gene, lipoxygenase gene, or collagen alpha gene, such as a collagen alpha 1(I) gene, preferably of an albumin gene.

The term ‘a nucleic acid sequence which is derived from a variant of the 3′UTR of a [ . . . ] gene’ preferably refers to a nucleic acid sequence, which is based on a variant of the 3′UTR sequence of a gene, such as on a variant of the 3′UTR of an albumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, or a collagen alpha gene, such as a collagen alpha 1(I) gene, or on a part thereof as described above. This term includes sequences corresponding to the entire sequence of the variant of the 3′UTR of a gene, i.e. the full length variant 3′UTR sequence of a gene, and sequences corresponding to a fragment of the variant 3′UTR sequence of a gene. A fragment in this context preferably consists of a continuous stretch of nucleotides corresponding to a continuous stretch of nucleotides in the full-length variant 3′UTR, which represents at least 20%, preferably at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, even more preferably at least 80%, and most preferably at least 90% of the full-length variant 3′UTR. Such a fragment of a variant, in the sense of the present invention, is preferably a functional fragment of a variant as described herein.

In a particularly preferred embodiment, the at least one mRNA of the inventive composition comprises at least one 5′-untranslated region element (5′UTR element). Preferably, the at least one 5′UTR element comprises or consists of a nucleic acid sequence, which is derived from the 5′UTR of a TOP gene or which is derived from a fragment, homolog or variant of the 5′UTR of a TOP gene.

It is particularly preferred that the 5′UTR element does not comprise a TOP-motif or a 5′TOP, as defined above.

In some embodiments, the nucleic acid sequence of the 5′UTR element, which is derived from a 5′UTR of a TOP gene, terminates at its 3′-end with a nucleotide located at position 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 upstream of the start codon (e.g. A(U/T)G) of the gene or mRNA it is derived from. Thus, the 5′UTR element does not comprise any part of the protein coding region. Thus, preferably, the only protein coding part of the at least one mRNA of the inventive composition is provided by the coding region.

The nucleic acid sequence derived from the 5′UTR of a TOP gene is preferably derived from a eukaryotic TOP gene, preferably a plant or animal TOP gene, more preferably a chordate TOP gene, even more preferably a vertebrate TOP gene, most preferably a mammalian TOP gene, such as a human TOP gene.

For example, the 5′UTR element is prefereably selected from 5′-UTR elements comprising or consisting of a nucleic acid sequence, which is derived from a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700, whose disclosure is incorporated herein by reference, from the homologs of SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700, from a variant thereof, or preferably from a corresponding RNA sequence. The term “homologs of SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700” refers to sequences of other species than homo sapiens, which are homologous to the sequences according to SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700.

In a preferred embodiment, the 5′UTR element of the RNA according to the invention comprises or consists of a nucleic acid sequence, which is derived from a nucleic acid sequence extending from nucleotide position 5 (i.e. the nucleotide that is located at position 5 in the sequence) to the nucleotide position immediately 5′ to the start codon (located at the 3′ end of the sequences), e.g. the nucleotide position immediately 5′ to the ATG sequence, of a nucleic acid sequence selected from SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700, from the homologs of SEQ ID NOs:1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700 from a variant thereof, or a corresponding RNA sequence. It is particularly preferred that the 5′ UTR element is derived from a nucleic acid sequence extending from the nucleotide position immediately 3′ to the 5′TOP to the nucleotide position immediately 5′ to the start codon (located at the 3′ end of the sequences), e.g. the nucleotide position immediately 5′ to the ATG sequence, of a nucleic acid sequence selected from SEQ ID NOs:1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700, from the homologs of SEQ ID NOs:1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO2013/143700, from a variant thereof, or a corresponding RNA sequence.

In a particularly preferred embodiment, the 5′UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5′UTR of a TOP gene encoding a ribosomal protein or from a variant of a 5′UTR of a TOP gene encoding a ribosomal protein. For example, the 5′UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5′UTR of a nucleic acid sequence according to any of SEQ ID NOs: 67, 170, 193, 244, 259, 554, 650, 675, 700, 721, 913, 1016, 1063, 1120, 1138, and 1284-1360 of the patent application WO2013/143700, a corresponding RNA sequence, a homolog thereof, or a variant thereof as described herein, preferably lacking the 5′TOP motif. As described above, the sequence extending from position 5 to the nucleotide immediately 5′ to the ATG (which is located at the 3′end of the sequences) corresponds to the 5′UTR of said sequences.

Preferably, the 5′UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5′UTR of a TOP gene encoding a ribosomal Large protein (RPL) or from a homolog or variant of a 5′UTR of a TOP gene encoding a ribosomal Large protein (RPL). For example, the 5′UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5′UTR of a nucleic acid sequence according to any of SEQ ID NOs: 67, 259, 1284-1318, 1344, 1346, 1348-1354, 1357, 1358, 1421 and 1422of the patent application WO2013/143700, a corresponding RNA sequence, a homolog thereof, or a variant thereof as described herein, preferably lacking the 5′TOP motif.

In a particularly preferred embodiment, the 5′UTR element comprises or consists of a nucleic acid sequence which is derived from the 5′UTR of a ribosomal protein Large 32 gene, preferably from a vertebrate ribosomal protein Large 32 (L32) gene, more preferably from a mammalian ribosomal protein Large 32 (L32) gene, most preferably from a human ribosomal protein Large 32 (L32) gene, or from a variant of the 5′UTR of a ribosomal protein Large 32 gene, preferably from a vertebrate ribosomal protein Large 32 (L32) gene, more preferably from a mammalian ribosomal protein Large 32 (L32) gene, most preferably from a human ribosomal protein Large 32 (L32) gene, wherein preferably the 5′UTR element does not comprise the 5′TOP of said gene.

Accordingly, in a particularly preferred embodiment, the 5′UTR element comprises or consists of a nucleic acid sequence, which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 61137 (5′-UTR of human ribosomal protein Large 32 lacking the 5′ terminal oligopyrimidine tract: GGCGCTGCCTACGGAGGTGGCAGCCATCTCCTTCTCGGCATC; corresponding to SEQ ID NO: 1368 of the patent application WO2013/143700) or preferably to a corresponding RNA sequence (such as SEQ ID NO: 61138), or wherein the at least one 5′UTR element comprises or consists of a fragment of a nucleic acid sequence which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 61137 or more preferably to a corresponding RNA sequence (SEQ ID NO: 61138), wherein, preferably, the fragment is as described above, i.e. being a continuous stretch of nucleotides representing at least 20% etc. of the full-length 5′UTR. Preferably, the fragment exhibits a length of at least about 20 nucleotides or more, preferably of at least about 30 nucleotides or more, more preferably of at least about 40 nucleotides or more. Preferably, the fragment is a functional fragment as described herein.

In some embodiments, the RNA according to the invention comprises a 5′UTR element, which comprises or consists of a nucleic acid sequence, which is derived from the 5′UTR of a vertebrate TOP gene, such as a mammalian, e.g. a human TOP gene, selected from RPSA, RPS2, RPS3, RPS3A, RPS4, RPS5, RPS6, RPS7, RPS8, RPS9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS27, RPS27A, RPS28, RPS29, RPS30, RPL3, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10, RPL10A, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL23A, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36, RPL36A, RPL37, RPL37A, RPL38, RPL39, RPL40, RPL41, RPLP0, RPLP1, RPLP2, RPLP3, RPLP0, RPLP1, RPLP2, EEF1A1, EEF1B2, EEF1D, EEF1G, EEF2, EIF3E, EIF3F, EIF3H, EIF2S3, EIF3C, EIF3K, EIF3EIP, EIF4A2, PABPC1, HNRNPA1, TPT1, TUBB1, UBA52, NPM1, ATP5G2, GNB2L1, NME2, UQCRB, or from a homolog or variant thereof, wherein preferably the 5′UTR element does not comprise a TOP-motif or the 5′TOP of said genes, and wherein optionally the 5′UTR element starts at its 5′-end with a nucleotide located at position 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 downstream of the 5′terminal oligopyrimidine tract (TOP) and wherein further optionally the 5′UTR element which is derived from a 5′UTR of a TOP gene terminates at its 3′-end with a nucleotide located at position 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 upstream of the start codon (A(U/T)G) of the gene it is derived from.

In further particularly preferred embodiments, the 5′UTR element comprises or consists of a nucleic acid sequence, which is derived from the 5′UTR of a ribosomal protein Large 32 gene (RPL32), a ribosomal protein Large 35 gene (RPL35), a ribosomal protein Large 21 gene (RPL21), an ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1) gene, an hydroxysteroid (17-beta) dehydrogenase 4 gene (HSD17B4), an androgen-induced 1 gene (AIG1), cytochrome c oxidase subunit Vic gene (COX6C), or a N-acylsphingosine amidohydrolase (acid ceramidase) 1 gene (ASAH1) or from a variant thereof, preferably from a vertebrate ribosomal protein Large 32 gene (RPL32), a vertebrate ribosomal protein Large 35 gene (RPL35), a vertebrate ribosomal protein Large 21 gene (RPL21), a vertebrate ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1) gene, a vertebrate hydroxysteroid (17-beta) dehydrogenase 4 gene (HSD17B4), a vertebrate androgen-induced 1 gene (AIG1), a vertebrate cytochrome c oxidase subunit Vic gene (COX6C), or a vertebrate N-acylsphingosine amidohydrolase (acid ceramidase) 1 gene (ASAH1) or from a variant thereof, more preferably from a mammalian ribosomal protein Large 32 gene (RPL32), a ribosomal protein Large 35 gene (RPL35), a ribosomal protein Large 21 gene (RPL21), a mammalian ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1) gene, a mammalian hydroxysteroid (17-beta) dehydrogenase 4 gene (HSD17B4), a mammalian androgen-induced 1 gene (AIG1), a mammalian cyto-chrome c oxidase subunit Vic gene (COX6C), or a mammalian N-acylsphingosine ami-dohydrolase (acid ceramidase) 1 gene (ASAH1) or from a variant thereof, most preferably from a human ribosomal protein Large 32 gene (RPL32), a human ribosomal protein Large 35 gene (RPL35), a human ribosomal protein Large 21 gene (RPL21), a human ATP syn-thase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1) gene, a human hydroxysteroid (17-beta) dehydrogenase 4 gene (HSD17B4), a human androgen-induced 1 gene (AIG1), a human cytochrome c oxidase subunit VIc gene (COX6C), or a human N-acylsphingosine amidohydrolase (acid ceramidase) 1 gene (ASAH1) or from a variant thereof, wherein preferably the 5′UTR element does not comprise the 5′TOP of said gene.

Accordingly, in a particularly preferred embodiment, the 5′UTR element comprises or consists of a nucleic acid sequence, which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 1368, or SEQ ID NOs: 1412-1420 of the patent application WO2013/143700, or a corresponding RNA sequence, or wherein the at least one 5′UTR element comprises or consists of a fragment of a nucleic acid sequence which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 1368, or SEQ ID NOs: 1412-1420 of the patent application WO2013/143700, wherein, preferably, the fragment is as described above, i.e. being a continuous stretch of nucleotides representing at least 20% etc. of the full-length 5′UTR. Preferably, the fragment exhibits a length of at least about 20 nucleotides or more, preferably of at least about 30 nucleotides or more, more preferably of at least about 40 nucleotides or more. Preferably, the fragment is a functional fragment as described herein.

Accordingly, in a particularly preferred embodiment, the 5′UTR element comprises or consists of a nucleic acid sequence, which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 61139 or 61140 (5′-UTR of ATP5A1 lacking the 5′ terminal oligopyrimidine tract: GCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTG CGGAGTAACTGCAAAG; corresponding to SEQ ID NO: 1414 of the patent application WO2013/143700) or preferably to a corresponding RNA sequence, or wherein the at least one 5′UTR element comprises or consists of a fragment of a nucleic acid sequence which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 61139or more preferably to a corresponding RNA sequence (SEQ ID NO: 61140), wherein, preferably, the fragment is as described above, i.e. being a continuous stretch of nucleotides representing at least 20% etc. of the full-length 5′UTR. Preferably, the fragment exhibits a length of at least about 20 nucleotides or more, preferably of at least about 30 nucleotides or more, more preferably of at least about 40 nucleotides or more. Preferably, the fragment is a functional fragment as described herein.

As described above, the 5′UTR element preferably comprises or consists of a nucleic acid sequence, which is derived from the 5′UTR of a hydroxysteroid (17-beta) dehydrogenase 4 gene (gene HSD17B4, which encodes peroxisomal multifunctional enzyme type 2, first identified as 17-beta-estradiol dehydrogenase). More preferably, such a 5′UTR element lacks the 5′ terminal oligopyrimidine tract.

Accordingly, in a particularly preferred embodiment, the 5′UTR element comprises or consists of a nucleic acid sequence, which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 61141 (5′-UTR of HSD17B4 lacking the 5′ terminal oligopyrimidine tract) or preferably to a corresponding RNA sequence (such as SEQ ID NO: 61142), or wherein the at least one 5′UTR element comprises or consists of a fragment of a nucleic acid sequence which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 61141 or more preferably to a corresponding RNA sequence (SEQ ID NO: 61142), wherein, preferably, the fragment is as described above, i.e. being a continuous stretch of nucleotides representing at least 20% etc. of the full-length 5′UTR. Preferably, the fragment exhibits a length of at least about 20 nucleotides or more, preferably of at least about 30 nucleotides or more, more preferably of at least about 40 nucleotides or more. Preferably, the fragment is a functional fragment as described herein.

Preferably, the at least one 5′UTR element and the at least one 3′UTR element act synergistically to increase protein production from the at least one mRNA of the inventive composition as described above.

In a particularly preferred embodiment, the RNA according to the invention comprises a histone stem-loop sequence/structure. Such histone stem-loop sequences are preferably selected from histone stem-loop sequences as disclosed in WO 2012/019780, the disclosure of which is incorporated herewith by reference.

-   A histone stem-loop sequence, suitable to be used within the present     invention, is preferably selected from at least one of the following     formulae (I) or (II):

wherein:

-   stem1 or stem2 bordering elements N₁₋₆ is a consecutive sequence of     1 to 6, preferably of 2 to 6, more preferably of 2 to 5, even more     preferably of 3 to 5, most preferably of 4 to 5 or 5 N, wherein each     N is independently from another selected from a nucleotide selected     from A, U, T, G and C, or a nucleotide analogue thereof; -   stem1 [N₀₋₂GN₃₋₅] is reverse complementary or partially reverse     complementary with element stem2, and is a consecutive sequence     between of 5 to 7 nucleotides;     -   wherein N₀₋₂ is a consecutive sequence of 0 to 2, preferably of         0 to 1, more preferably of 1 N, wherein each N is independently         from another selected from a nucleotide selected from A, U, T, G         and C or a nucleotide analogue thereof;     -   wherein N₃₋₅ is a consecutive sequence of 3 to 5, preferably of         4 to 5, more preferably of 4 N, wherein each N is independently         from another selected from a nucleotide selected from A, U, T, G         and C or a nucleotide analogue thereof, and     -   wherein G is guanosine or an analogue thereof, and may be         optionally replaced by a cytidine or an analogue thereof,         provided that its complementary nucleotide cytidine in stem2 is         replaced by guanosine; -   loop sequence [N₀₋₄(U/T)N₀₋₄] is located between elements stem1 and     stem2, and is a consecutive sequence of 3 to 5 nucleotides, more     preferably of 4 nucleotides;     -   wherein each N₀₋₄ is independent from another a consecutive         sequence of 0 to 4, preferably of 1 to 3, more preferably of 1         to 2 N, wherein each N is independently from another selected         from a nucleotide selected from A, U, T, G and C or a nucleotide         analogue thereof; and     -   wherein U/T represents uridine, or optionally thymidine; -   stem2 [N₃₋₅CN₀₋₂] is reverse complementary or partially reverse     complementary with element stem1, and is a consecutive sequence     between of 5 to 7 nucleotides;     -   wherein N₃₋₅ is a consecutive sequence of 3 to 5, preferably of         4 to 5, more preferably of 4 N, wherein each N is independently         from another selected from a nucleotide selected from A, U, T, G         and C or a nucleotide analogue thereof;     -   wherein N₀₋₂ is a consecutive sequence of 0 to 2, preferably of         0 to 1, more preferably of 1 N, wherein each N is independently         from another selected from a nucleotide selected from A, U, T, G         or C or a nucleotide analogue thereof; and     -   wherein C is cytidine or an analogue thereof, and may be         optionally replaced by a guanosine or an analogue thereof         provided that its complementary nucleoside guanosine in stem1 is         replaced by cytidine;

wherein

stem1 and stem2 are capable of base pairing with each other forming a reverse complementary sequence, wherein base pairing may occur between stem1 and stem2, e.g. by Watson-Crick base pairing of nucleotides A and U/T or G and C or by non-Watson-Crick base pairing e.g. wobble base pairing, reverse Watson-Crick base pairing, Hoogsteen base pairing, reverse Hoogsteen base pairing or are capable of base pairing with each other forming a partially reverse complementary sequence, wherein an incomplete base pairing may occur between stem1 and stem2, on the basis that one ore more bases in one stem do not have a complementary base in the reverse complementary sequence of the other stem.

-   According to a further preferred embodiment, the RNA according to     the invention may comprise at least one histone stem-loop sequence     according to at least one of the following specific formulae (Ia) or     (IIa):

wherein:

N, C, G, T and U are as defined above.

-   According to a further more particularly preferred embodiment, the     RNA according to the invention may comprise at least one histone     stem-loop sequence according to at least one of the following     specific formulae (Ib) or (IIb):

wherein:

N, C, G, T and U are as defined above.

A particular preferred histone stem-loop sequence is the sequence CAAAGGCTCTTTTCAGAGCCACCA (according to SEQ ID NO: 61157) or more preferably the corresponding RNA sequence CAAAGGCUCUUUUCAGAGCCACCA (according to SEQ ID NO: 61158).

According to another particularly preferred embodiment, the RNA according to the invention may additionally or alternatively encode a secretory signal peptide. Such signal peptides are sequences, which typically exhibit a length of about 15 to 30 amino acids and are preferably located at the N-terminus of the encoded peptide, without being limited thereto. Signal peptides as defined herein preferably allow the transport of the antibody or the fragment thereof as encoded by the at least one mRNA of the composition into a defined cellular compartiment, preferably the cell surface, the endoplasmic reticulum (ER) or the endosomal-lysosomal compartiment. Examples of secretory signal peptide sequences as defined herein include, without being limited thereto, signal sequences of classical or non-classical MHC-molecules (e.g. signal sequences of MHC I and II molecules, e.g. of the MHC class I molecule HLA-A*0201), signal sequences of cytokines or immunoglobulines as defined herein, signal sequences of the invariant chain of immunoglobulines or antibodies as defined herein, signal sequences of Lamp1, Tapasin, Erp57, Calretikulin, Calnexin, and further membrane associated proteins or of proteins associated with the endoplasmic reticulum (ER) or the endosomal-lysosomal compartiment. Most preferably, signal sequences of MHC class I molecule HLA-A*0201 may be used according to the present invention. For example, a signal peptide derived from HLA-A is preferably used in order to promote secretion of the encoded antibody as defined herein or a fragment or variant thereof. More preferably, an HLA-A signal peptide is fused to an encoded antibody as defined herein or to a fragment or variant thereof:

Any of the above modifications may be applied to the RNA of the present invention, and further to any RNA as used in the context of the present invention and may be, if suitable or necessary, be combined with each other in any combination, provided, these combinations of modifications do not interfere with each other in the respective at least one mRNA. A person skilled in the art will be able to take his choice accordingly.

The RNA, preferably an mRNA, according to the invention, which comprises at least one coding sequence as defined herein, may preferably comprise a 5′ UTR and/or a 3′ UTR preferably containing at least one histone stem-loop. Where, in addition to the antibody as defined herein or a fragment or variant thereof, a further peptide or protein is encoded by the at least one coding sequence of the RNA according to the invention, the encoded peptide or protein is preferably no histone protein, no reporter protein and/or no marker or selection protein, as defined herein. The 3′ UTR of the RNA according to the invention preferably comprises also a poly(A) and/or a poly(C) sequence as defined herein. The single elements of the 3′ UTR may occur therein in any order from 5′ to 3′ along the sequence of the RNA of the present invention. In addition, further elements as described herein, may also be contained, such as a stabilizing sequence as defined herein (e.g. derived from the UTR of a globin gene), IRES sequences, etc. Each of the elements may also be repeated in the RNA according to the invention at least once (particularly in di- or multicistronic constructs), preferably twice or more. As an example, the single elements may be present in the RNA according to the invention in the following order:

5′—coding region—histone stem-loop—poly(A)/(C) sequence—3′; or

5′—coding region—poly(A)/(C) sequence—histone stem-loop—3′; or

5′—coding region—histone stem-loop—polyadenylation signal—3′; or

5′—coding region—polyadenylation signal—histone stem-loop—3′; or

5′—coding region—histone stem-loop—histone stem-loop—poly(A)/(C) sequence—3′; or

5′—coding region—histone stem-loop—histone stem-loop—polyadenylation signal—3′; or

5′—coding region—stabilizing sequence—poly(A)/(C) sequence—histone stem-loop—3′; or

5′—coding region—stabilizing sequence—poly(A)/(C) sequence—poly(A)/(C) sequence—histone stem-loop—3′; etc.

According to a further embodiment, the RNA, preferably an mRNA, of the present invention preferably comprises at least one of the following structural elements: a 5′- and/or 3′-untranslated region element (UTR element), particularly a 5′-UTR element, which preferably comprises or consists of a nucleic acid sequence which is derived from the 5′-UTR of a TOP gene or from a fragment, homolog or a variant thereof, or a 5′- and/or 3′-UTR element which may preferably be derivable from a gene that provides a stable mRNA or from a homolog, fragment or variant thereof; a histone-stem-loop structure, preferably a histone-stem-loop in its 3′ untranslated region; a 5′-cap structure; a poly-A tail; or a poly(C) sequence.

According to some embodiments, it is particularly preferred that—if, in addition to an antibody as defined herein or a fragment or variant thereof, a further peptide or protein is encoded by the at least one coding sequence as defined herein—the encoded peptide or protein is preferably no histone protein, no reporter protein (e.g. Luciferase, GFP, EGFP, β-Galactosidase, particularly EGFP) and/or no marker or selection protein (e.g. alpha-Globin, Galactokinase and Xanthine:Guanine phosphoribosyl transferase (GPT)). In a preferred embodiment, the RNA according to the invention does not comprise a reporter gene or a marker gene. Preferably, the RNA according to the invention does not encode, for instance, luciferase; green fluorescent protein (GFP) and its variants (such as eGFP, RFP or BFP); α-globin; hypoxanthine-guanine phosphoribosyltransferase (HGPRT); β-galactosidase; galactokinase; alkaline phosphatase; secreted embryonic alkaline phosphatase (SEAP)) or a resistance gene (such as a resistance gene against neomycin, puromycin, hygromycin and zeocin). In a preferred embodiment, the RNA according to the invention does not encode luciferase. In another embodiment, the RNA according to the invention does not encode GFP or a variant thereof.

According to a preferred embodiment, the RNA according to the present invention comprises, preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,     -   b) at least one coding sequence comprising or consisting of a         nucleic acid sequence selected from the group consisting of SEQ         ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,         61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,         61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,         61347, 61350-61356, 61358, 61360, 61363-61369, 61371,         61374-61380, 61382, 61386-61399, 61402-61404, 61416,         61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,         61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,         61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,         61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,         61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,         61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,         61662-61664, 61668-61674, 61676, 61679-61685, 61687,         61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,         61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,         61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,         61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,         61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,         61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,         61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,         61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,         61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,         61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,         61733, and 61734; or a fragment or variant thereof,     -   c) a poly(A) tail, preferably consisting of 10 to 200, 10 to         100, 40 to 80 or 50 to 70 adenosine nucleotides,     -   d) a poly(C) tail, preferably consisting of 10 to 200, 10 to         100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and     -   e) a histone stem-loop, preferably comprising the RNA sequence         according to SEQ ID NO: 61158.

More preferably, the RNA according to the invention comprises, preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,     -   b) at least one coding sequence comprising or consisting of a         nucleic acid sequence selected from the group consisting of SEQ         ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,         61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,         61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,         61347, 61350-61356, 61358, 61360, 61363-61369, 61371,         61374-61380, 61382, 61386-61399, 61402-61404, 61416,         61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,         61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,         61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,         61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,         61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,         61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,         61662-61664, 61668-61674, 61676, 61679-61685, 61687,         61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,         61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,         61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,         61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,         61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,         61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,         61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,         61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,         61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,         61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,         61733, and 61734; or a fragment or variant thereof,     -   c) a 3′-UTR element comprising a nucleic acid sequence, which is         derived from an α-globin gene, preferably comprising the RNA         sequence according to SEQ ID NO: 61150, or a homolog, a fragment         or a variant thereof,     -   d) a poly(A) tail, preferably consisting of 10 to 200, 10 to         100, 40 to 80 or 50 to 70 adenosine nucleotides,     -   e) a poly(C) tail, preferably consisting of 10 to 200, 10 to         100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and     -   f) a histone stem-loop, preferably comprising the RNA sequence         according to SEQ ID NO: 61158.

In a further embodiment, the RNA according to the invention comprises, preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,     -   b) a 5′-UTR element, which preferably comprises or consists of a         nucleic acid sequence, which is derived from the 5′-UTR of a TOP         gene, preferably comprising an RNA sequence corresponding to the         nucleic acid sequence according to SEQ ID NO: 61138, or a         homolog, a fragment or a variant thereof,     -   c) at least one coding sequence comprising or consisting of a         nucleic acid sequence selected from the group consisting of SEQ         ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,         61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,         61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,         61347, 61350-61356, 61358, 61360, 61363-61369, 61371,         61374-61380, 61382, 61386-61399, 61402-61404, 61416,         61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,         61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,         61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,         61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,         61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,         61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,         61662-61664, 61668-61674, 61676, 61679-61685, 61687,         61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,         61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,         61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,         61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,         61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,         61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,         61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,         61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,         61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,         61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,         61733, and 61734; or a fragment or variant thereof,     -   d) a 3′-UTR element comprising a nucleic acid sequence, which is         preferably derived from an α-globin gene, preferably comprising         the RNA sequence according to SEQ ID NO: 61150, or a homolog, a         fragment or a variant thereof; and/or         -   a 3′-UTR element comprising a nucleic acid sequence, which             is derived from an albumin gene, preferably comprising the             RNA sequence according to SEQ ID NO: 61154, or a homolog, a             fragment or a variant thereof or the RNA sequence according             to SEQ ID NO: 61156, or a homolog, a fragment or a variant             thereof,     -   e) a poly(A) tail, preferably consisting of 10 to 200, 10 to         100, 40 to 80 or 50 to 70 adenosine nucleotides,     -   f) a poly(C) tail, preferably consisting of 10 to 200, 10 to         100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and     -   g) a histone stem-loop, preferably comprising the RNA sequence         according to SEQ ID NO: 61158.

Moreover, it is also preferred that the RNA according to the invention comprises, preferably in 5′ to 3′ direction, the following elements:

-   -   a) a 5′-CAP structure, preferably m7GpppN,     -   b) a 5′-UTR element, which preferably comprises or consists of a         nucleic acid sequence, which is derived from the 5′-UTR of a TOP         gene, preferably comprising an RNA sequence corresponding to the         nucleic acid sequence according to SEQ ID NO: 61142, or a         homolog, a fragment or a variant thereof,     -   c) at least one coding sequence comprising or consisting of a         nucleic acid sequence selected from the group consisting of SEQ         ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235,         61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309,         61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345,         61347, 61350-61356, 61358, 61360, 61363-61369, 61371,         61374-61380, 61382, 61386-61399, 61402-61404, 61416,         61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458,         61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485,         61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536,         61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574,         61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613,         61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659,         61662-61664, 61668-61674, 61676, 61679-61685, 61687,         61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720,         61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278,         61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359,         61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411,         61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462,         61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480,         61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564,         61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609,         61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638,         61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732,         61733, and 61734; or a fragment or variant thereof,     -   d) a 3′-UTR element comprising a nucleic acid sequence, which is         preferably derived from an α-globin gene, preferably comprising         the RNA sequence according to SEQ ID NO: 61150, or a homolog, a         fragment or a variant thereof; and/or         -   a 3′-UTR element comprising a nucleic acid sequence, which             is derived from an albumin gene, preferably comprising the             RNA sequence according to SEQ ID NO: 61154, or a homolog, a             fragment or a variant thereof or the RNA sequence according             to SEQ ID NO: 61156, or a homolog, a fragment or a variant             thereof,     -   e) a poly(A) tail, preferably consisting of 10 to 200, 10 to         100, 40 to 80 or 50 to 70 adenosine nucleotides,     -   f) a poly(C) tail, preferably consisting of 10 to 200, 10 to         100, 20 to 70, 20 to 60 or 10 to 40 cytosine nucleotides, and     -   g) a histone stem-loop, preferably comprising the RNA sequence         according to SEQ ID NO: 61158.

Preferably, the RNA according to the present invention additionally codes a tag for purification chosen from the group consisting of a hexahistidine tag (HIS tag, polyhistidine tag), a streptavidin tag (Strep tag), an SBP tag (streptavidin-binding tag) or a GST (glutathione S-transferase) tag, or codes for a tag for purification via an antibody epitope chosen from the group consisting of antibody-binding tags, a Myc tag, a Swa11 epitope, a FLAG tag or an HA tag.

It is also preferred that the RNA according to the present invention additionally (in addition to the antibody or fragment or variant thereof) encodes a signal peptide and/or a localization sequence, in particular a secretion sequence. Such signal peptides are (signal) sequences which conventionally comprise a length of from 15 to 30 amino acids and are preferably localized on the N-terminus of the coded antibody. Signal peptides typically render possible transport of a protein or peptide fused therewith (here e.g. an antibody) to or into a defined cell compartment, preferably the cell surface, the endoplasmic reticulum or the endosomal-lysosomal compartment. Examples of signal sequences which can be used according to the invention are e.g. signal sequences of conventional and non-conventional MHC molecules, cytokines, immunoglobulins, the invariant chain, Lamp1, tapasin, Erp57, calreticulin and calnexin, and all further membrane-located, endosomally-lysosomally or endoplasmic reticulum-associated proteins. The signal peptide of the human MHC class I molecule HLA-A*0201 is preferably used.

Sequences which render possible transport of a protein or peptide fused therewith (here e.g. an antibody) to or into a defined cell compartment, preferably the cell surface, the nucleus, the nucleus region, the plasma membrane, the cytosol, the endoplasmic reticulum, the organelles, the mitochondria, the Golgi apparatus or the endosomal-lysosomal compartment, also include, without being limited thereto, so-called routing signals, sorting signals, retention signals or salvage signals and membrane topology-stop transfer signals (cf. Pugsley, A. P., Protein Targeting, Academic Press, Inc. (1989)) at the level of the RNA according to the invention. In this connection, localization sequences include nucleic acid sequences which encode e.g. signals, i.e. amino acid sequences, such as, for example, KDEL (SEQ ID NO: 61176) (Munro, et al., Cell 48:899-907 (1987)) DDEL (SEQ ID NO: 61177), DEEL (SEQ ID NO: 61178), QEDL (SEQ ID NO: 61179) and RDEL (SEQ ID NO: 61180) (Hangejorden, et al., J. Biol. Chem. 266:6015 (1991)) for the endoplasmic reticulum; PKKKRKV (SEQ ID NO: 61181) (Lanford, et al. Cell 46:575 (1986)) PQKKIKS (SEQ ID NO: 61182) (Stanton, L. W., et al., Proc. Natl. Acad. Sci USA 83:1772 (1986); QPKKP (SEQ ID NO: 61183) (Harlow, et al., Mol. Cell Biol. 5:1605 1985), and RKKR (SEQ ID NO: 61184) for the nucleus; and RKKRRQRRRAHQ (SEQ ID NO: 61185) (Seomi, et al., J. Virology 64:1803 (1990)), RQARRNRRRRWRERQR (SEQ ID NO: 61186) (Kubota, et al., Biochem. and Biophy, Res. Comm. 162:963 (1989)), and MPLTRRRPAASQALAPPTP (SEQ ID NO: 61187) (Siomi, et al., Cell 55:197 (1988)) for the nucleus region; MDDQRDLISNNEQLP (SEQ ID NO: 61188) (Bakke, et al., Cell 63:707-716 (1990)) for the endosomal compartment (see, for example, Letourneur, et al., Cell 69:1183 (1992) for the targeting of liposomes). Myristoylation sequences can furthermore be used in order to lead the expressed protein or peptide (here e.g. an antibody) to the plasma membrane, or to certain various sub-cell compartments, such as the nucleus region, the organelles, the mitochondria and the Golgi apparatus. Corresponding amino acid sequences which are coded by a corresponding codon sequence of the RNA according to the invention are given below. The sequence MLFNLRXXLNNAAFRHGHNFMVRNFRCGQPLX (SEQ ID NO: 61189) can be used to lead the antibody to the mitochondrial matrix (Pugsley, supra). See Tang, et al., J. Bio. Chem. 207:10122, in respect of the localization of proteins (antibodies) to the Golgi apparatus; for the localization of proteins to the plasma membrane: GCVCSSNP (SEQ ID NO: 61190), GQTVTTPL (SEQ ID NO: 61191), GQELSQHE (SEQ ID NO: 61192), GNSPSYNP (SEQ ID NO: 61193), GVSGSKGQ (SEQ ID NO: 61194), GQTITTPL (SEQ ID NO: 61195), GQTLTTPL (SEQ ID NO: 61196), GQIFSRSA (SEQ ID NO: 61197), GQIHGLSP (SEQ ID NO: 61198), GARASVLS (SEQ ID NO: 61199), and GCTLSAEE (SEQ ID NO: 61200); to the endoplasmic reticulum GQNLSTSN (SEQ ID NO: 61201); to the nucleus GAALTILV (SEQ ID NO: 61202) and GAALTLLG (SEQ ID NO: 61203); to the endoplasmic reticulum and to the cytoplasm GAQVSSQK (SEQ ID NO: 61204) and GAQLSRNT (SEQ ID NO: 61205); to the Golgi apparatus, to the nucleus, to the cytoplasm and to the cytoskeleton: GNAAAAKK (SEQ ID NO: 61206); to the cytoplasm and to the cytoskeleton GNEASYPL (SEQ ID NO: 61207); and to the plasma membrane and to the cytoskeleton GSSKSKPK (SEQ ID NO: 61208). Such sequences as described above are preferably used for RNAs which code for intrabodies, i.e antibodies which are retained in the cell and are not secreted. Thus, the localization sequence is preferably chosen from one of the sequences according to SEQ ID NO: 61176 to 61208.

It is also preferred that the RNA according to the present invention comprises a nucleic acid sequence selected from the group consisting of nucleic acid sequences according to SEQ ID NOs: 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, 61734.

The RNA according to the present invention may be prepared using any method known in the art, including synthetic methods such as e.g. solid phase RNA synthesis, as well as in vitro methods, such as RNA in vitro transcription reactions.

Combination of at least Two Distinct RNA's

In a further aspect the present invention provides a combination of at least two distinct RNA's as described above, preferably for use in medicine. As used herein, the term “RNA's” refers in particular to “RNA species” (with one RNA species typically referring to one or more identical RNA molecules). Accordingly, the terms “RNA's” and “RNA species” may be used interchangeably. The term “distinct” refers in particular to the coding sequence of the RNA. In other words, the at least two distinct RNA's differ in particular in their coding sequences. Accordingly, the at least two distinct RNA's may relate to (encode) the same or different antibodies. For example, the at least two distinct RNA's may encode two distinct antibodies or fragments or variants thereof as described herein.

However, it is preferred that the at least two distinct RNA's encode different fragments of the same antibody. In other words, an antibody (or a fragment or variant thereof as described herein) may be encoded (i) by one single RNA as described above or (ii) by at least two distinct RNA's, wherein each of the distinct RNA's preferably encodes a distinct fragment of the antibody. More preferably, one RNA of the at least two distinct RNA's encodes a heavy chain variable region of an antibody or a fragment thereof and another RNA of the at least two distinct RNA's encodes the corresponding light chain variable region of the antibody or the fragment thereof. Even more preferably, one RNA of the at least two distinct RNA's encodes a heavy chain of an antibody and another RNA of the at least two distinct RNA's encodes the corresponding light chain of the antibody. Thereby, the term “corresponding” means that heavy and light chain (or heavy chain variable region and light chain variable region) are from the same antibody (or from the same fragment or variant thereof). Accordingly, it is preferred that (i) the RNA according to the present invention as described above or (ii) the combination of the at least two distinct RNA's according to the present invention as a whole encodes a functional antibody (or a functional fragment or variant thereof) as described herein. In other words, an antibody (or a fragment or variant thereof), which is expressed by use of (i) the RNA according to the present invention as described above or (ii) the combination of the at least two distinct RNA's according to the present invention as a whole, is preferably a functional antibody (or a functional fragment or variant thereof) as described herein.

Preferably, in such a combination of at least two distinct RNA's the RNA encoding the complete heavy chain, the heavy chain variable region, or a fragment thereof, and the RNA encoding the complete light chain, the light chain variable region, or a fragment thereof comprise identical 3′UTR elements and/or identical 5′UTR elements. Preferred 3′UTR elements, 5′UTR elements and other structural features are the same as described above for the RNA according to the present invention.

Particularly preferably, in a combination for use according to the present invention the distinct RNA's, in particular the RNA encoding the complete heavy chain, the heavy chain variable region, or a fragment thereof, and the RNA encoding the complete light chain, the light chain variable region, or a fragment thereof may comprise, preferably in 5′ to 3′ direction, the following elements:

-   -   a) an identical 5′-CAP structure, preferably m7GpppN;     -   b) an identical 5′-UTR element, which preferably comprises or         consists of a nucleic acid sequence, which is derived from the         5′-UTR of a TOP gene, preferably comprising an RNA sequence         corresponding to the nucleic acid sequence according to SEQ ID         NO: 61138, or a homolog, a fragment or a variant thereof;     -   c) at least one coding sequence, which is distinct for the at         least two distinct RNA's comprised by the combination for use         according to the present invention;     -   d) an identical 3′-UTR element comprising a nucleic acid         sequence, which is preferably derived from an α-globin gene,         preferably comprising the RNA sequence according to SEQ ID NO:         61150, or a homolog, a fragment or a variant thereof; and/or         -   an identical 3′-UTR element comprising a nucleic acid             sequence, which is preferably derived from an albumin gene,             preferably comprising the RNA sequence according to SEQ ID             NO: 61154, or a homolog, a fragment or a variant thereof or             the RNA sequence according to SEQ ID NO: 61156, or a             homolog, a fragment or a variant thereof;     -   e) an identical poly(A) tail, preferably consisting of 10 to         200, 10 to 100, 40 to 80 or 50 to 70 adenosine nucleotides;     -   f) an identical poly(C) tail, preferably consisting of 10 to         200, 10 to 100, 20 to 70, 20 to 60 or 10 to 40 cytosine         nucleotides; and/or     -   g) an identical histone stem-loop, preferably comprising the RNA         sequence according to SEQ ID NO: 61158.

Most preferably, in a combination for use according to the present invention the distinct RNA's, in particular the RNA encoding the complete heavy chain, the heavy chain variable region, or a fragment thereof, and the RNA encoding the complete light chain, the light chain variable region, or a fragment thereof may comprise, preferably in 5′ to 3′ direction, the following elements:

-   -   a) an identical 5′-CAP structure, preferably m7GpppN;     -   b) an identical 5′-UTR element, which preferably comprises or         consists of a nucleic acid sequence, which is derived from the         5′-UTR of a TOP gene, preferably comprising an RNA sequence         corresponding to the nucleic acid sequence according to SEQ ID         NO: 61142, or a homolog, a fragment or a variant thereof;     -   c) at least one coding sequence, which is distinct for the at         least two distinct RNA's comprised by the combination for use         according to the present invention; d) an identical 3′-UTR         element comprising a nucleic acid sequence, which is preferably     -   derived from an α-globin gene, preferably comprising the RNA         sequence according to SEQ ID NO: 61150, or a homolog, a fragment         or a variant thereof; and/or         -   an identical 3′-UTR element comprising a nucleic acid             sequence, which is preferably derived from an albumin gene,             preferably comprising the RNA sequence according to SEQ ID             NO: 61154, or a homolog, a fragment or a variant thereof or             the RNA sequence according to SEQ ID NO: 61156, or a             homolog, a fragment or a variant thereof;     -   e) an identical poly(A) tail, preferably consisting of 10 to         200, 10 to 100, 40 to 80 or 50 to 70 adenosine nucleotides;     -   f) an identical poly(C) tail, preferably consisting of 10 to         200, 10 to 100, 20 to 70, 20 to 60 or 10 to 40 cytosine         nucleotides; and/or     -   g) an identical histone stem-loop, preferably comprising the RNA         sequence according to SEQ ID NO: 61158.

Thereby, an optimal stoichiometric ratio of the amino acid sequences encoded by the at least two RNA's can be achieved, which in turn results in optimal antibody formation.

In the combination of the at least to distinct RNA's as described herein for use according to the present invention, the at least to distinct RNA's as described herein may be administered separately or in the same composition.

In the combination of the at least to distinct RNA's as described herein for use according to the present invention, the at least to distinct RNA's as described herein are preferably administered at about the same time.

“At about the same time”, as used herein, means in particular simultaneous administration or that directly after administration of one RNA the other RNA is administered. The skilled person understands that “directly after” includes the time necessary to prepare the second administration—in particular the time necessary for exposing and disinfecting the location for the second administration as well as appropriate preparation of the “administration device” (e.g., syringe, pump, etc.). The term “simultaneous administration” as used herein also includes if the periods of administration of the at least two distinct RNA's overlap or if, for example, one RNA is administered over a longer period of time, such as 30 min, 1 h, 2 h or even more, e.g. by infusion, and the other RNA is administered at some time during such a long period.

Alternatively, the at least two RNA's may be administered consecutively. However, it is preferred that the at least two distinct RNA's are administered at the same day with the time between administration of the first RNA and administration of the second RNA being preferably no more than 6 hours, more preferably no more than 3 hours, even more preferably no more than 2 hours and most preferably no more than 1 h.

Preferably, the at least two distinct RNA's are administered in a therapeutically effective amount. A “therapeutically effective amount”, as used herein, is the amount which is sufficient for the alleviation of the symptoms of the disease or condition being treated and/or for prophylaxis of the symptoms of the disease or condition being prevented. In other words, a “therapeutically effective amount” means an amount of the at least two distinct RNA's that is sufficient to significantly induce a positive modification of a disease or disorder, i.e. an amount of the at least two distinct RNA's, that elicits the biological or medicinal response in a tissue, system, animal or human that is being sought. The term also includes the amount of the at least two distinct RNA's sufficient to reduce the progression of the disease, e.g., to notably reduce or inhibit the tumor growth or infection and thereby elicit the response being sought, in particular such response could be an immune response involving the antibodies or antibody fragments encoded by the RNA according to the invention. At the same time, however, a “therapeutically effective amount” is preferably small enough to avoid serious side-effects, that is to say to permit a sensible relationship between advantage and risk. The determination of these limits typically lies within the scope of sensible medical judgment. A “therapeutically effective amount” of the at least two distinct RNA's will furthermore vary in connection with the particular condition to be treated and also with the age and physical condition of the patient to be treated, the body weight, general health, sex, diet, time of administration, rate of excretion, drug combination, the activity of the at least two distinct RNA's, the severity of the condition, the duration of the treatment, the nature of the accompanying therapy, of the particular pharmaceutically acceptable carrier used, and similar factors, within the knowledge and experience of the accompanying doctor.

In the combination of the at least to distinct RNA's as described herein for use according to the present invention, the at least to distinct RNA's as described herein may be administered via the same or different routes of administration. Preferably, the at least two distinct RNA's are administered via the same route of administration. Preferred routes of administration are described below, in the context of the (pharmaceutical) composition. Those preferred routes of administration apply accordingly for the combination for use according to the present invention.

In the combination of the at least to distinct RNA's as described herein for use according to the present invention, the at least to distinct RNA's as described herein may be provided in the same or in distinct compositions. Preferably, the at least to distinct RNA's as described herein are provided in the same composition. Compositions comprising the RNA according to the present invention are described in detail in the following.

The combination of at least two distinct RNA's is preferably used for the treatment (prevention and/or therapy) of a variety of diseases as described below (in the context of the use of the RNA and the composition according to the invention and in the context of the treatment method) in more detail. Those details and preferred embodiments apply accordingly for the combination for use according to the present invention.

Composition comprising the RNA according to the Present Invention

In a further aspect, the present invention provides a composition comprising the RNA comprising at least one coding sequence as described herein and a pharmaceutically acceptable carrier. The composition according to the invention is preferably provided as a pharmaceutical composition or as a (passive) vaccine. As used herein, the term “passive vaccine” refers to a vaccine for use in passive immunization.

According to a preferred embodiment, the (pharmaceutical) composition or the (passive) vaccine according to the invention comprises the RNA of the present invention, wherein the at least one coding sequence of the RNA comprises or consists of a nucleic acid sequence encoding an antibody, or a fragment or variant of an antibody, wherein the antibody preferably comprises or consists of an amino acid sequence selected from the group consisting of SEQ ID NO: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, and 61730; or a fragment or variant of any one of said amino acid sequences.

Preferably, the (pharmaceutical) composition or the (passive) vaccine according to the invention comprises the RNA of the present invention, wherein the at least one coding sequence of the RNA comprises or consists of a nucleic acid sequence encoding an antibody, or a fragment or variant of an antibody, wherein the antibody preferably comprises or consists of an amino acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with an amino acid sequence selected from the group consisting of SEQ ID NO: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, and 61730; or a fragment or variant of any one of said amino acid sequences.

More preferably, the (pharmaceutical) composition or the (passive) vaccine according to the invention comprises the RNA of the present invention, wherein the at least one coding sequence of the RNA comprises or consists of a nucleic acid sequence encoding an antibody, or a fragment or variant of an antibody, wherein the antibody preferably comprises or consists of an amino acid sequence having a sequence identity of at least 80% with an amino acid sequence selected from the group consisting of SEQ ID NO: 1-7642, 61212-61214, 61236-61238, 61245-61247, 61269-61271, 61279-61281, 61303-61305, 61312, 61320, 61324, 61332, 61338, 61346, 61349, 61357, 61362, 61370, 61373, 61381, 61384, 61385, 61400, 61401, 61418, 61426, 61429, 61437, 61440, 61441, 61456, 61457, 61469, 61470, 61475, 61476, 61481, 61482, 61487, 61488, 61493, 61494, 61499, 61500, 61515, 61516, 61521, 61522, 61537, 61538, 61543, 61544, 61559, 61560, 61565, 61573, 61576, 61584, 61587, 61588, 61603, 61606, 61609, 61612, 61618, 61619, 61634, 61635, 61639, 61640, 61644, 61645, 61660, 61661, 61667, 61675, 61678, 61686, 61689, 61697, 61700, 61708, 61711, 61719, 61722, and 61730; or a fragment or variant of any one of said amino acid sequences.

In preferred embodiments, the (pharmaceutical) composition or the (passive) vaccine according to the invention comprises the RNA of the present invention, wherein the at least one coding sequence of the RNA comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any of said nucleic acid sequences.

According to another embodiment, the (pharmaceutical) composition or the (passive) vaccine according to the invention comprises the RNA of the present invention, wherein the at least one coding sequence of the RNA comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

According to a particularly preferred embodiment, the (pharmaceutical) composition or the (passive) vaccine according to the invention comprises the RNA of the present invention, wherein the at least one coding sequence of the RNA comprises or consists of a nucleic acid sequence having a sequence identity of at least 80% with a nucleic acid sequence selected from the group consisting of SEQ ID NO: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734; or a fragment or variant of any one of said nucleic acid sequences.

In the context of the present invention, the RNA comprised by the (pharmaceutical) composition or the (passive) vaccine may encode one or more of the antibodies defined herein or a fragment or variant thereof.

The (pharmaceutical) composition or (passive) vaccine according to the invention may thus comprise the RNA of the present invention, wherein the RNA encodes one specific antibody of the antibodies defined herein or a fragment or a variant thereof. In that embodiment, the (pharmaceutical) composition or (passive) vaccine preferably comprises the RNA according to the invention comprising the at least one coding sequence as described herein encoding the antibody or a fragment or variant thereof.

Alternatively, the (pharmaceutical) composition or (passive) vaccine of the present invention may comprise at least one RNA according to the invention, wherein the at least one RNA encodes at least two, three, four, five, six, seven, eight, nine, ten, eleven or twelve distinct antibodies as defined herein or a fragment or variant thereof. Preferably, the (pharmaceutical) composition or the (passive) vaccine comprises several classes of the RNA according to the invention, wherein each RNA species encodes one of the antibodies or a fragment or variant thereof. In another embodiment, the RNA comprised in the (pharmaceutical) composition or (passive) vaccine is a bi- or multicistronic RNA as defined herein, which encodes the at least two, three, four, five, six, seven, eight, nine, ten, eleven or twelve distinct antibodies or fragments or variants thereof. Mixtures between these embodiments are also envisaged, such as compositions comprising more than one RNA species, wherein at least one RNA species may be monocistronic, while at least one other RNA species may be bi- or multicistronic.

The RNA according to the present invention as described above, in particular the RNA comprised in the (pharmaceutical) composition or the (passive) vaccine according to the present invention, may thus comprise any combination of the nucleic acid sequences as defined herein.

In a particularly preferred embodiment, the composition according to the present invention comprises at least two distinct RNA's according to the present inventions. Thereby, the details of the at least two distinct RNA's according to the present inventions as described above, in the context of the combination for use according to the present invention, apply accordingly for the at least two distinct RNA's comprised in the composition according to the present invention. Accordingly, it is preferred that one RNA of the at least two distinct RNA's encodes a heavy chain variable region of an antibody or a fragment thereof and another RNA of the at least two distinct RNA's encodes the corresponding light chain variable region of the antibody or the fragment thereof. More preferably, one RNA of the at least two distinct RNA's encodes a heavy chain of an antibody and another RNA of the at least two distinct RNA's encodes the corresponding light chain of the antibody. It is also preferred that the RNA encoding the heavy chain variable region or a fragment thereof and the RNA encoding the light chain variable region or a fragment thereof comprise identical 5′UTR elements and/or identical 3′UTR elements and/or identical further elements as described above, in the context of the combination for use according to the present invention.

In a preferred embodiment of the composition according to the invention, the RNA is complexed with one or more cationic or polycationic compounds, preferably with cationic or polycationic polymers, cationic or polycationic peptides or proteins, e.g. protamine, cationic or polycationic polysaccharides and/or cationic or polycationic lipids.

According to a preferred embodiment, the RNA of the composition according to the present invention may be complexed with lipids to form one or more liposomes, lipoplexes, or lipid nanoparticles. Therefore, in one embodiment, the inventive composition comprises liposomes, lipoplexes, and/or lipid nanoparticles comprising the at least one mRNA.

Lipid-based formulations have been increasingly recognized as one of the most promising delivery systems for RNA due to their biocompatibility and their ease of large-scale production. Cationic lipids have been widely studied as synthetic materials for delivery of RNA. After mixing together, nucleic acids are condensed by cationic lipids to form lipid/nucleic acid complexes known as lipoplexes. These lipid complexes are able to protect genetic material from the action of nucleases and deliver it into cells by interacting with the negatively charged cell membrane.

Lipoplexes can be prepared by directly mixing positively charged lipids at physiological pH with negatively charged nucleic acids.

Conventional liposomes consist of a lipid bilayer that can be composed of cationic, anionic, or neutral (phospho)lipids and cholesterol, which encloses an aqueous core. Both the lipid bilayer and the aqueous space can incorporate hydrophobic or hydrophilic compounds, respectively. Liposome characteristics and behaviour in vivo can be modified by addition of a hydrophilic polymer coating, e.g. polyethylene glycol (PEG), to the liposome surface to confer steric stabilization. Furthermore, liposomes can be used for specific targeting by attaching ligands (e.g., antibodies, peptides, and carbohydrates) to its surface or to the terminal end of the attached PEG chains (Front Pharmacol. 2015 Dec. 1; 6:286).

Liposomes are colloidal lipid-based and surfactant-based delivery systems composed of a phospholipid bilayer surrounding an aqueous compartment. They may present as spherical vesicles and can range in size from 20 nm to a few microns. Cationic lipid-based liposomes are able to complex with negatively charged nucleic acids via electrostatic interactions, resulting in complexes that offer biocompatibility, low toxicity, and the possibility of the large-scale production required for in vivo clinical applications. Liposomes can fuse with the plasma membrane for uptake; once inside the cell, the liposomes are processed via the endocytic pathway and the genetic material is then released from the endosome/carrier into the cytoplasm. Liposomes have long been perceived as drug delivery vehicles because of their superior biocompatibility, given that liposomes are basically analogs of biological membranes, and can be prepared from both natural and synthetic phospholipids (Int J Nanomedicine. 2014; 9: 1833-1843).

Cationic liposomes have been traditionally the most commonly used non-viral delivery systems for oligonucleotides, including plasmid DNA, antisense oligos, and siRNA/small hairpin RNA-shRNA). Cationic lipids, such as DOTAP, (1,2-dioleoyl-3-trimethylammonium-propane) and DOTMA (N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethyl-ammonium methyl sulfate) can form complexes or lipoplexes with negatively charged nucleic acids to form nanoparticles by electrostatic interaction, providing high in vitro transfection efficiency . Furthermore, neutral lipid-based nanoliposomes for RNA delivery as e.g. neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC)-based nanoliposomes were developed. (Adv Drug Deliv Rev. 2014 February; 66: 110-116.).

Therefore, in one embodiment the RNA of the composition according to the present invention is complexed with cationic lipids and/or neutral lipids and thereby forms liposomes, lipid nanoparticles, lipoplexes or neutral lipid-based nanoliposomes.

In a preferred embodiment, the composition according to the invention comprises the RNA according to the invention that is formulated together with a cationic or polycationic compound and/or with a polymeric carrier. Accordingly, in a further embodiment of the invention, it is preferred that the RNA as defined herein or any other nucleic acid comprised in the inventive (pharmaceutical) composition or (passive) vaccine is associated with or complexed with a cationic or polycationic compound or a polymeric carrier, optionally in a weight ratio selected from a range of about 6:1 (w/w) to about 0.25:1 (w/w), more preferably from about 5:1 (w/w) to about 0.5:1 (w/w), even more preferably of about 4:1 (w/w) to about 1:1 (w/w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w) of mRNA or nucleic acid to cationic or polycationic compound and/or with a polymeric carrier; or optionally in a nitrogen/phosphate (N/P) ratio of mRNA or nucleic acid to cationic or polycationic compound and/or polymeric carrier in the range of about 0.1-10, preferably in a range of about 0.3-4 or 0.3-1, and most preferably in a range of about 0.5-1 or 0.7-1, and even most preferably in a range of about 0.3-0.9 or 0.5-0.9. More preferably, the N/P ratio of the at least one mRNA to the one or more polycations is in the range of about 0.1 to 10, including a range of about 0.3 to 4, of about 0.5 to 2, of about 0.7 to 2 and of about 0.7 to 1.5.

Therein, the RNA as defined herein or any other nucleic acid comprised in the (pharmaceutical) composition or (passive) vaccine according to the invention can also be associated with a vehicle, transfection or complexation agent for increasing the transfection efficiency and/or the immunostimulatory properties of the RNA according to the invention or of optionally comprised further included nucleic acids.

Cationic or polycationic compounds, being particularly preferred agents in this context include protamine, nucleoline, spermine or spermidine, or other cationic peptides or proteins, such as poly-L-lysine (PLL), poly-arginine, basic polypeptides, cell penetrating peptides (CPPs), including HIV-binding peptides, HIV-1 Tat (HIV), Tat-derived peptides, Penetratin, VP22 derived or analog peptides, HSV VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs), PpT620, prolin-rich peptides, arginine-rich peptides, lysine-rich peptides, MPG-peptide(s), Pep-1, L-oligomers, Calcitonin peptide(s), Antennapedia-derived peptides (particularly from Drosophila antennapedia), pAntp, plsl, FGF, Lactoferrin, Transportan, Buforin-2, Bac715-24, SynB, SynB(1), pVEC, hCT-derived peptides, SAP, or histones. More preferably, the RNA according to the invention is complexed with one or more polycations, preferably with protamine or oligofectamine, most preferably with protamine. In this context protamine is particularly preferred.

Additionally, preferred cationic or polycationic proteins or peptides may be selected from the following proteins or peptides having the following total formula (III):

(Arg)_(l);(Lys)_(m);(His)_(n);(Orn)_(o);(Xaa)_(x),   (formula (III))

wherein l+m+n+o+x=8-15, and l, m, nor o independently of each other may be any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15, provided that the overall content of Arg, Lys, His and Orn represents at least 50% of all amino acids of the oligopeptide; and Xaa may be any amino acid selected from native (=naturally occurring) or non-native amino acids except of Arg, Lys, His or Orn; and x may be any number selected from 0, 1, 2, 3 or 4, provided, that the overall content of Xaa does not exceed 50% of all amino acids of the oligopeptide. Particularly preferred cationic peptides in this context are e.g. Arg₇, Arg₈, Arg₉, H₃R₉, R₉H₃, H₃R₉H₃, YSSR₉SSY, (RKH)₄, Y(RKH)₂R, etc. In this context the disclosure of WO 2009/030481 is incorporated herewith by reference.

Further preferred cationic or polycationic compounds, which can be used as transfection or complexation agent may include cationic polysaccharides, for example chitosan, polybrene, cationic polymers, e.g. polyethyleneimine (PEI), cationic lipids, e.g. DOTMA: [1-(2,3-sioleyloxy)propyl)]-N,N,N-trimethylammonium chloride, DMRIE, di-C14-amidine, DOTIM, SAINT, DC-Chol, BGTC, CTAP, DOPC, DODAP, DOPE: Dioleyl phosphatidylethanol-amine, DOSPA, DODAB, DOIC, DMEPC, DOGS: Dioctadecylamidoglicylspermin, DIMRI: Dimyristo-oxypropyl dimethyl hydroxyethyl ammonium bromide, DOTAP: dioleoyloxy-3-(trimethylammonio)propane, DC-6-14: O,O-ditetradecanoyl-N-(α-trimethylammonioacetyl)diethanolamine chloride, CLIP1: rac-[(2,3-dioctadecyloxypropyl)(2-hydroxyethyl)]-dimethylammonium chloride, CLIP6: rac-[2(2,3-dihexadecyloxypropyl-oxymethyloxy)ethyl]trimethylammonium, CLIP9: rac-[2(2,3-dihexadecyloxypropyl-oxysuccinyloxy)ethyl]-trimethylammonium, oligofectamine, or cationic or polycationic polymers, e.g. modified polyaminoacids, such as β-aminoacid-polymers or reversed polyamides, etc., modified polyethylenes, such as PVP (poly(N-ethyl-4-vinylpyridinium bromide)), etc., modified acrylates, such as pDMAEMA (poly(dimethylaminoethyl methylacrylate)), etc., modified amidoamines such as pAMAM (poly(amidoamine)), etc., modified polybetaaminoester (PBAE), such as diamine end modified 1,4 butanediol diacrylate-co-5-amino-1-pentanol polymers, etc., dendrimers, such as polypropylamine dendrimers or pAMAM based dendrimers, etc., polyimine(s), such as PEI: poly(ethyleneimine), poly(propyleneimine), etc., polyallylamine, sugar backbone based polymers, such as cyclodextrin based polymers, dextran based polymers, chitosan, etc., silan backbone based polymers, such as PMOXA-PDMS copolymers, etc., blockpolymers consisting of a combination of one or more cationic blocks (e.g. selected from a cationic polymer as mentioned above) and of one or more hydrophilic or hydrophobic blocks (e.g. polyethyleneglycole); etc.

According to a preferred embodiment, the composition of the present invention comprises the RNA as defined herein and a polymeric carrier. A polymeric carrier used according to the invention might be a polymeric carrier formed by disulfide-crosslinked cationic components. The disulfide-crosslinked cationic components may be the same or different from each other. The polymeric carrier can also contain further components. It is also particularly preferred that the polymeric carrier used according to the present invention comprises mixtures of cationic peptides, proteins or polymers and optionally further components as defined herein, which are crosslinked by disulfide bonds as described herein. In this context, the disclosure of WO 2012/013326 is incorporated herewith by reference.

In this context, the cationic components, which form basis for the polymeric carrier by disulfide-crosslinkage, are typically selected from any suitable cationic or polycationic peptide, protein or polymer suitable for this purpose, particular any cationic or polycationic peptide, protein or polymer capable of complexing the RNA as defined herein or a further nucleic acid comprised in the composition, and thereby preferably condensing the RNA or the nucleic acid. The cationic or polycationic peptide, protein or polymer, is preferably a linear molecule, however, branched cationic or polycationic peptides, proteins or polymers may also be used.

Every disulfide-crosslinking cationic or polycationic protein, peptide or polymer of the polymeric carrier, which may be used to complex the RNA according to the invention or any further nucleic acid comprised in the (pharmaceutical) composition or (passive) vaccine of the present invention contains at least one —SH moiety, most preferably at least one cysteine residue or any further chemical group exhibiting an —SH moiety, capable of forming a disulfide linkage upon condensation with at least one further cationic or polycationic protein, peptide or polymer as cationic component of the polymeric carrier as mentioned herein.

As defined above, the polymeric carrier, which may be used to complex the RNA of the present invention or any further nucleic acid comprised in the (pharmaceutical) composition or (passive) vaccine according to the invention may be formed by disulfide-crosslinked cationic (or polycationic) components. Preferably, such cationic or polycationic peptides or proteins or polymers of the polymeric carrier, which comprise or are additionally modified to comprise at least one —SH moiety, are selected from, proteins, peptides and polymers as defined herein for complexation agent.

In a further particular embodiment, the polymeric carrier which may be used to complex the RNA as defined herein or any further nucleic acid comprised in the (pharmaceutical) composition or (passive) vaccine according to the invention may be selected from a polymeric carrier molecule according to generic formula (IV):

L-P¹-S-[S-P²-S]_(n)-S-P³-L   formula (IV)

wherein,

-   P¹ and P³ are different or identical to each other and represent a     linear or branched hydrophilic polymer chain, each P¹ and P³     exhibiting at least one —SH-moiety, capable to form a disulfide     linkage upon condensation with component P², or alternatively with     (AA), (AA)_(x), or [(AA)_(x)]_(z) if such components are used as a     linker between P¹ and P² or P³ and P²) and/or with further     components (e.g. (AA), (AA)_(x), [(AA)_(x)]_(z) or L), the linear or     branched hydrophilic polymer chain selected independent from each     other from polyethylene glycol (PEG),     poly-N-(2-hydroxypropyl)methacrylamide,     poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl     L-asparagine), poly(2-(methacryloyloxy)ethyl phosphorylcholine),     hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the     hydrophilic polymer chain exhibits a molecular weight of about 1 kDa     to about 100 kDa, preferably of about 2 kDa to about 25 kDa; or more     preferably of about 2 kDa to about 10 kDa, e.g. about 5 kDa to about     25 kDa or 5 kDa to about 10 kDa; -   P² is a cationic or polycationic peptide or protein, e.g. as defined     above for the polymeric carrier formed by disulfide-crosslinked     cationic components, and preferably having a length of about 3 to     about 100 amino acids, more preferably having a length of about 3 to     about 50 amino acids, even more preferably having a length of about     3 to about 25 amino acids, e.g. a length of about 3 to 10, 5 to 15,     10 to 20 or 15 to 25 amino acids, more preferably a length of about     5 to about 20 and even more preferably a length of about 10 to about     20; or     -   is a cationic or polycationic polymer, e.g. as defined above for         the polymeric carrier formed by disulfide-crosslinked cationic         components, typically having a molecular weight of about 0.5 kDa         to about 30 kDa, including a molecular weight of about 1 kDa to         about 20 kDa, even more preferably of about 1.5 kDa to about 10         kDa, or having a molecular weight of about 0.5 kDa to about 100         kDa, including a molecular weight of about 10 kDa to about 50         kDa, even more preferably of about 10 kDa to about 30 kDa; each         P² exhibiting at least two —SH-moieties, capable to form a         disulfide linkage upon condensation with further components P²         or component(s) P¹ and/or P³ or alternatively with further         components (e.g. (AA), (AA)_(x), or [(AA)_(x)]_(z)); -   —S—S— is a (reversible) disulfide bond (the brackets are omitted for     better readability), wherein S preferably represents sulphur or a     —SH carrying moiety, which has formed a (reversible) disulfide bond.     The (reversible) disulfide bond is preferably formed by condensation     of —SH-moieties of either components P¹ and P², P² and P², or P² and     P³, or optionally of further components as defined herein (e.g. L,     (AA), (AA)_(x), [(AA)_(x)]_(z), etc); The —SH-moiety may be part of     the structure of these components or added by a modification as     defined below; -   L is an optional ligand, which may be present or not, and may be     selected independent from the other from RGD, Transferrin, Folate, a     signal peptide or signal sequence, a localization signal or     sequence, a nuclear localization signal or sequence (NLS), an     antibody, a cell penetrating peptide, (e.g. TAT or KALA), a ligand     of a receptor (e.g. cytokines, hormones, growth factors etc), small     molecules (e.g. carbohydrates like mannose or galactose or synthetic     ligands), small molecule agonists, inhibitors or antagonists of     receptors (e.g. RGD peptidomimetic analogues), or any further     protein as defined herein, etc.; -   n is an integer, typically selected from a range of about 1 to 50,     preferably from a range of about 1, 2 or 3 to 30, more preferably     from a range of about 1, 2, 3, 4, or 5 to 25, or a range of about 1,     2, 3, 4, or 5 to 20, or a range of about 1, 2, 3, 4, or 5 to 15, or     a range of about 1, 2, 3, 4, or 5 to 10, including e.g. a range of     about 4 to 9, 4 to 10, 3 to 20, 4 to 20, 5 to 20, or 10 to 20, or a     range of about 3 to 15, 4 to 15, 5 to 15, or 10 to 15, or a range of     about 6 to 11 or 7 to 10. Most preferably, n is in a range of about     1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3,     or 4 to 9, in a range of about 1, 2, 3, or 4 to 8, or in a range of     about 1, 2, or 3 to 7.

In this context, the disclosure of WO 2011/026641 is incorporated herewith by reference. Each of hydrophilic polymers P¹ and P³ typically exhibits at least one —SH-moiety, wherein the at least one —SH-moiety is capable to form a disulfide linkage upon reaction with component P² or with component (AA) or (AA)_(x), if used as linker between P¹ and P² or P³ and P² as defined below and optionally with a further component, e.g. L and/or (AA) or (AA)_(x), e.g. if two or more —SH-moieties are contained. The following subformulae “P¹—S—S—P²” and “P²—S—S—P³” within generic formula (IV) above (the brackets are omitted for better readability), wherein any of S, P¹ and P³ are as defined herein, typically represent a situation, wherein one-SH-moiety of hydrophilic polymers P¹ and P³ was condensed with one —SH-moiety of component P² of generic formula (IV) above, wherein both sulphurs of these —SH-moieties form a disulfide bond —S—S— as defined herein in formula (IV). These —SH-moieties are typically provided by each of the hydrophilic polymers P¹ and P³, e.g. via an internal cysteine or any further (modified) amino acid or compound which carries a —SH moiety. Accordingly, the subformulae “P¹—S—S—P²” and “P²—S—S—P³” may also be written as “P¹-Cys-Cys-P²” and “P²-Cys-Cys-P³”, if the —SH-moiety is provided by a cysteine, wherein the term Cys-Cys represents two cysteines coupled via a disulfide bond, not via a peptide bond. In this case, the term “—S—S—” in these formulae may also be written as “—S-Cys”, as “-Cys-S” or as “-Cys-Cys-”. In this context, the term “-Cys-Cys-” does not represent a peptide bond but a linkage of two cysteines via their —SH-moieties to form a disulfide bond. Accordingly, the term “-Cys-Cys-” also may be understood generally as “-(Cys-S)—(S-Cys)-”, wherein in this specific case S indicates the sulphur of the —SH-moiety of cysteine. Likewise, the terms “—S-Cys” and “-Cys-S” indicate a disulfide bond between a —SH containing moiety and a cysteine, which may also be written as “—S—(S-Cys)” and “-(Cys-S)—S”. Alternatively, the hydrophilic polymers P¹ and P³ may be modified with a —SH moiety, preferably via a chemical reaction with a compound carrying a —SH moiety, such that each of the hydrophilic polymers P¹ and P³ carries at least one such —SH moiety. Such a compound carrying a —SH moiety may be e.g. an (additional) cysteine or any further (modified) amino acid, which carries a —SH moiety. Such a compound may also be any non-amino compound or moiety, which contains or allows to introduce a —SH moiety into hydrophilic polymers P¹ and P³ as defined herein. Such non-amino compounds may be attached to the hydrophilic polymers P¹ and P³ of formula (IV) of the polymeric carrier according to the present invention via chemical reactions or binding of compounds, e.g. by binding of a 3-thio propionic acid or thioimolane, by amide formation (e.g. carboxylic acids, sulphonic acids, amines, etc), by Michael addition (e.g maleinimide moieties, α,β-unsatured carbonyls, etc), by click chemistry (e.g. azides or alkines), by alkene/alkine methatesis (e.g. alkenes or alkines), imine or hydrozone formation (aldehydes or ketons, hydrazins, hydroxylamins, amines), complexation reactions (avidin, biotin, protein G) or components which allow S_(n)-type substitution reactions (e.g halogenalkans, thiols, alcohols, amines, hydrazines, hydrazides, sulphonic acid esters, oxyphosphonium salts) or other chemical moieties which can be utilized in the attachment of further components. A particularly preferred PEG derivate in this context is alpha-Methoxy-omega-mercapto poly(ethylene glycol). In each case, the SH-moiety, e.g. of a cysteine or of any further (modified) amino acid or compound, may be present at the terminal ends or internally at any position of hydrophilic polymers P¹ and P³. As defined herein, each of hydrophilic polymers P¹ and P³ typically exhibits at least one —SH-moiety preferably at one terminal end, but may also contain two or even more —SH-moieties, which may be used to additionally attach further components as defined herein, preferably further functional peptides or proteins e.g. a ligand, an amino acid component (AA) or (AA)_(x), antibodies, cell penetrating peptides or enhancer peptides (e.g. TAT, KALA), etc.

Preferably, the inventive composition comprises at least one RNA as defined herein, which is complexed with one or more polycations, and at least one free RNA, wherein the at least one complexed RNA is preferably identical to the at least one free RNA. In this context, it is particularly preferred that the composition of the present invention comprises the RNA according to the invention that is complexed at least partially with a cationic or polycationic compound and/or a polymeric carrier, preferably cationic proteins or peptides. In this context, the disclosure of WO 2010/037539 and WO 2012/113513 is incorporated herewith by reference. Partially means that only a part of the RNA as defined herein is complexed in the composition according to the invention with a cationic compound and that the rest of the RNA as defined herein is (comprised in the inventive (pharmaceutical) composition or (passive) vaccine) in uncomplexed form (“free”). Preferably, the molar ratio of the complexed RNA to the free RNA is selected from a molar ratio of about 0.001:1 to about 1:0.001, including a ratio of about 1:1. More preferably the ratio of complexed RNA to free RNA (in the (pharmaceutical) composition or (passive) vaccine of the present invention) is selected from a range of about 5:1 (w/w) to about 1:10 (w/w), more preferably from a range of about 4:1 (w/w) to about 1:8 (w/w), even more preferably from a range of about 3:1 (w/w) to about 1:5 (w/w) or 1:3 (w/w), and most preferably the ratio of complexed mRNA to free mRNA in the inventive pharmaceutical composition or (passive) vaccine is selected from a ratio of about 1:1 (w/w).

The complexed RNA in the (pharmaceutical) composition or (passive) vaccine according to the present invention, is preferably prepared according to a first step by complexing the RNA according to the invention with a cationic or polycationic compound and/or with a polymeric carrier, preferably as defined herein, in a specific ratio to form a stable complex. In this context, it is highly preferable, that no free cationic or polycationic compound or polymeric carrier or only a negligibly small amount thereof remains in the component of the complexed RNA after complexing the RNA. Accordingly, the ratio of the RNA and the cationic or polycationic compound and/or the polymeric carrier in the component of the complexed RNA is typically selected in a range so that the RNA is entirely complexed and no free cationic or polycationic compound or polymeric carrier or only a negligibly small amount thereof remains in the composition.

Preferably the ratio of the RNA as defined herein to the cationic or polycationic compound and/or the polymeric carrier, preferably as defined herein, is selected from a range of about 6:1 (w/w) to about 0.25:1 (w/w), more preferably from about 5:1 (w/w) to about 0.5:1 (w/w), even more preferably of about 4:1 (w/w) to about 1:1 (w/w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w). Alternatively, the ratio of the RNA as defined herein to the cationic or polycationic compound and/or the polymeric carrier, preferably as defined herein, in the component of the complexed mRNA, may also be calculated on the basis of the nitrogen/phosphate ratio (N/P-ratio) of the entire complex. In the context of the present invention, an N/P-ratio is preferably in the range of about 0.1-10, preferably in a range of about 0.3-4 and most preferably in a range of about 0.5-2 or 0.7-2 regarding the ratio of RNA: cationic or polycationic compound and/or polymeric carrier, preferably as defined herein, in the complex, and most preferably in a range of about 0.7-1.5, 0.5-1 or 0.7-1, and even most preferably in a range of about 0.3-0.9 or 0.5-0.9, preferably provided that the cationic or polycationic compound in the complex is a cationic or polycationic cationic or polycationic protein or peptide and/or the polymeric carrier as defined above. In this specific embodiment the complexed RNA as defined herein is also emcompassed in the term “adjuvant component”.

In other embodiments, the composition according to the invention comprising the RNA as defined herein may be administered naked without being associated with any further vehicle, transfection or complexation agent.

It has to be understood and recognized, that according to the present invention, the inventive composition may comprise at least one naked RNA as defined herein, preferably an mRNA, and/or at least one formulated/complexed RNA as defined herein, preferably an mRNA, wherein every formulation and/or complexation as disclosed above may be used.

In a further aspect, the present invention provides a (passive) vaccine, which is based on the RNA according to the invention comprising at least one coding sequence as defined herein. The (passive) vaccine according to the invention is preferably a (pharmaceutical) composition as defined herein.

Accordingly, the (passive) vaccine according to the invention is based on the same components as the (pharmaceutical) composition described herein. Insofar, it may be referred to the description of the (pharmaceutical) composition as provided herein. In particular, in embodiments, where the (passive) vaccine comprises more than one RNA component (such as a plurality of RNAs according to the invention, wherein each encodes a distinct antibody or, preferably, distinct fragments of the same antibody), the (passive) vaccine may, however, be provided in physically separate form and may be administered by separate administration steps, for example as described above in the context of a combination for use according to the present invention. The (passive) vaccine according to the invention may correspond to the (pharmaceutical) composition as described herein, especially where the mRNA components are provided by one single composition. However, the inventive (passive) vaccine may also be provided physically separated. For instance, in embodiments, wherein the (passive) vaccine comprises more than one RNA (e.g. as described above in the context of a combination for use according to the present invention), these RNA's may be provided such that, for example, two, three, four, five or six separate compositions, which may contain at least one RNA species each (e.g. three distinct mRNA species), each encoding distinct antibodies or distinct fragments of the same antibody, are provided, which may or may not be combined. Also, the inventive (passive) vaccine may be a combination of at least two distinct compositions, each composition comprising at least one mRNA encoding at least one of the antibodies as defined herein or encoding at least one fragment of an antibody. Alternatively, the (passive) vaccine may be provided as a combination of at least one mRNA, preferably at least two, three, four, five, six or more mRNAs, each encoding one of the antibodies defined herein or one fragment of the same antibody. The (passive) vaccine may be combined to provide one single composition prior to its use or it may be used such that more than one administration is required to administer the distinct mRNA species encoding any of the antibody combinations as defined herein or encoding any of the antibody fragment combinations as defined herein (such as, for example, heavy and light chain of the same antibody encoded by distinct mRNA's). If the (passive) vaccine contains at least one mRNA molecule, typically at least two mRNA molecules, encoding an antibody combination or an antibody fragment combination as defined herein, it may e.g. be administered by one single administration (combining all mRNA species), by at least two separate administrations. Accordingly; any combination of mono-, bi- or multicistronic mRNAs encoding the at least one antibody or any combination of antibodies or of antibody fragments as defined herein (and optionally further antibodies), provided as separate entities (containing one mRNA species) or as combined entity (containing more than one mRNA species), is understood as a (passive) vaccine according to the present invention. According to a preferred embodiment of the inventive (passive) vaccine, the at least one antibody or the fragment thereof, preferably a combination as defined herein of at least two, three, four, five, six or more antibodies or fragments thereof encoded by the inventive composition as a whole, is provided as an individual (monocistronic) mRNA, which is administered separately.

As with the (pharmaceutical) composition according to the present invention, the entities of the (passive) vaccine may be provided in liquid and or in dry (e.g. lyophilized) form. They may contain further components, in particular further components allowing for its pharmaceutical use. The (passive) vaccine or the (pharmaceutical) composition may, e.g., additionally contain a pharmaceutically acceptable carrier and/or further auxiliary substances and additives and/or adjuvants.

The (passive) vaccine or (pharmaceutical) composition typically comprises a safe and effective amount of the RNA according to the invention as defined herein, encoding an antibody or a fragment or variant thereof as defined herein or a combination of antibodies as defined herein. As used herein, “safe and effective amount” means an amount of the RNA that is sufficient to significantly induce a positive modification of a disease or disorder to be treated with the inventive composition. At the same time, however, a “safe and effective amount” is small enough to avoid serious side-effects, that is to say to permit a sensible relationship between advantage and risk. The determination of these limits typically lies within the scope of sensible medical judgment. In relation to the (passive) vaccine or (pharmaceutical) composition of the present invention, the expression “safe and effective amount” preferably means an amount of the RNA (and thus of the encoded antibody or fragment thereof) that is suitable for treating a disease or disorder as described herein. Such a “safe and effective amount” of the RNA of the (pharmaceutical) composition or (passive) vaccine as defined herein may furthermore be selected in dependence of the type of RNA, e.g. monocistronic, bi- or even multicistronic RNA, since a bi- or even multicistronic RNA may lead to a significantly higher expression of the encoded antibody(s) than the use of an equal amount of a monocistronic RNA. A “safe and effective amount” of the RNA of the (pharmaceutical) composition or (passive) vaccine as defined above will furthermore vary in connection with the particular condition to be treated and also with the age and physical condition of the patient to be treated, the severity of the condition, the duration of the treatment, the nature of the accompanying therapy, of the particular pharmaceutically acceptable carrier used, and similar factors, within the knowledge and experience of the accompanying doctor. The (passive) vaccine or composition according to the invention can be used according to the invention for human and also for veterinary medical purposes, as a pharmaceutical composition or as a (passive) vaccine.

In a preferred embodiment, the RNA of the (pharmaceutical) composition, (passive) vaccine or kit of parts according to the invention is provided in lyophilized form. Preferably, the lyophilized RNA is reconstituted in a suitable buffer, advantageously based on an aqueous carrier, prior to administration, e.g. Ringer-Lactate solution, which is preferred, Ringer solution, a phosphate buffer solution. In a preferred embodiment, the (pharmaceutical) composition, the (passive) vaccine or the kit of parts according to the invention contains at least two, three, four, five, six or more RNAs, preferably mRNAs which are provided separately in lyophilized form (optionally together with at least one further additive) and which are preferably reconstituted separately in a suitable buffer (such as Ringer-Lactate solution) prior to their use so as to allow individual administration of each of the (monocistronic) RNAs.

The (passive) vaccine or (pharmaceutical) composition according to the invention may typically contain a pharmaceutically acceptable carrier. The expression “pharmaceutically acceptable carrier” as used herein preferably includes the liquid or non-liquid basis of the inventive (passive) vaccine. If the inventive (passive) vaccine is provided in liquid form, the carrier will be water, typically pyrogen-free water; isotonic saline or buffered (aqueous) solutions, e.g phosphate, citrate etc. buffered solutions. Particularly for injection of the inventive (passive) vaccine, water or preferably a buffer, more preferably an aqueous buffer, may be used, containing a sodium salt, preferably at least 50 mM of a sodium salt, a calcium salt, preferably at least 0.01 mM of a calcium salt, and optionally a potassium salt, preferably at least 3 mM of a potassium salt. According to a preferred embodiment, the sodium, calcium and, optionally, potassium salts may occur in the form of their halogenides, e.g. chlorides, iodides, or bromides, in the form of their hydroxides, carbonates, hydrogen carbonates, or sulfates, etc. Without being limited thereto, examples of sodium salts include e.g. NaCl, NaI, NaBr, Na₂CO₃, NaHCO₃, Na₂SO₄, examples of the optional potassium salts include e.g. KCl, KI, KBr, K₂CO₃, KHCO₃, K₂SO₄, and examples of calcium salts include e.g. CaCl₂, CaI₂, CaBr₂, CaCO₃, CaSO₄, Ca(OH)₂. Furthermore, organic anions of the aforementioned cations may be contained in the buffer. According to a more preferred embodiment, the buffer suitable for injection purposes as defined above, may contain salts selected from sodium chloride (NaCl), calcium chloride (CaCl₂) and optionally potassium chloride (KCl), wherein further anions may be present additional to the chlorides. CaCl₂ can also be replaced by another salt like KCl. Typically, the salts in the injection buffer are present in a concentration of at least 50 mM sodium chloride (NaCl), at least 3 mM potassium chloride (KCl) and at least 0.01 mM calcium chloride (CaCl₂). The injection buffer may be hypertonic, isotonic or hypotonic with reference to the specific reference medium, i.e. the buffer may have a higher, identical or lower salt content with reference to the specific reference medium, wherein preferably such concentrations of the afore mentioned salts may be used, which do not lead to damage of cells due to osmosis or other concentration effects. Reference media are e.g. in “in vivo” methods occurring liquids such as blood, lymph, cytosolic liquids, or other body liquids, or e.g. liquids, which may be used as reference media in “in vitro” methods, such as common buffers or liquids. Such common buffers or liquids are known to a skilled person. Ringer-Lactate solution is particularly preferred as a liquid basis.

However, one or more compatible solid or liquid fillers or diluents or encapsulating compounds may be used as well, which are suitable for administration to a person. The term “compatible” as used herein means that the constituents of the inventive (passive) vaccine are capable of being mixed with the RNA according to the invention as defined herein, in such a manner that no interaction occurs, which would substantially reduce the pharmaceutical effectiveness of the inventive (passive) vaccine under typical use conditions. Pharmaceutically acceptable carriers, fillers and diluents must, of course, have sufficiently high purity and sufficiently low toxicity to make them suitable for administration to a person to be treated. Some examples of compounds which can be used as pharmaceutically acceptable carriers, fillers or constituents thereof are sugars, such as, for example, lactose, glucose, trehalose and sucrose; starches, such as, for example, corn starch or potato starch; dextrose; cellulose and its derivatives, such as, for example, sodium carboxymethylcellulose, ethylcellulose, cellulose acetate; powdered tragacanth; malt; gelatin; tallow; solid glidants, such as, for example, stearic acid, magnesium stearate; calcium sulfate; vegetable oils, such as, for example, groundnut oil, cottonseed oil, sesame oil, olive oil, corn oil and oil from theobroma; polyols, such as, for example, polypropylene glycol, glycerol, sorbitol, mannitol and polyethylene glycol; alginic acid.

The choice of a pharmaceutically acceptable carrier is determined, in principle, by the manner, in which the pharmaceutical composition or (passive) vaccine according to the invention is administered. The composition or (passive) vaccine can be administered, for example, systemically or locally. Routes for systemic administration in general include, for example, transdermal, oral, parenteral routes, including subcutaneous, intravenous, intramuscular, intraarterial, intradermal and intraperitoneal injections and/or intranasal administration routes. Routes for local administration in general include, for example, topical administration routes but also intradermal, transdermal, subcutaneous, or intramuscular injections or intralesional, intracranial, intrapulmonal, intracardial, and sublingual injections. More preferably, composition or (passive) vaccines according to the present invention may be administered by an intradermal, subcutaneous, or intramuscular route, preferably by injection, which may be needle-free and/or needle injection. Compositions/vaccines are therefore preferably formulated in liquid or solid form. The suitable amount of the vaccine or composition according to the invention to be administered can be determined by routine experiments, e.g. by using animal models. Such models include, without implying any limitation, rabbit, sheep, mouse, rat, dog and non-human primate models. Preferred unit dose forms for injection include sterile solutions of water, physiological saline or mixtures thereof. The pH of such solutions should be adjusted to about 7.4. Suitable carriers for injection include hydrogels, devices for controlled or delayed release, polylactic acid and collagen matrices. Suitable pharmaceutically acceptable carriers for topical application include those which are suitable for use in lotions, creams, gels and the like. If the inventive composition or vaccine is to be administered perorally, tablets, capsules and the like are the preferred unit dose form. The pharmaceutically acceptable carriers for the preparation of unit dose forms which can be used for oral administration are well known in the prior art. The choice thereof will depend on secondary considerations such as taste, costs and storability, which are not critical for the purposes of the present invention, and can be made without difficulty by a person skilled in the art.

Further additives which may be included in the inventive vaccine or composition are emulsifiers, such as, for example, Tween; wetting agents, such as, for example, sodium lauryl sulfate; colouring agents; taste-imparting agents, pharmaceutical carriers; tablet-forming agents; stabilizers; antioxidants; preservatives.

Kit comprising the RNA according to the Present Invention

According to another aspect of the present invention, the present invention also provides a kit, in particular a kit of parts, comprising the RNA according to the present invention, the (pharmaceutical) composition, and/or the vaccine according to the invention, optionally a liquid vehicle for solubilising and optionally technical instructions with information on the administration and dosage of the RNA, the composition and/or the vaccine. The technical instructions may contain information about administration and dosage of the RNA, the composition and/or the vaccine. Such kits, preferably kits of parts, may be applied e.g. for any of the applications or uses as described herein, preferably for the use of the RNA according to the invention (for the preparation of an inventive medicament, preferably a vaccine), for the treatment (prophylaxis or therapy) of a disease or disorder as described herein. The kits may also be applied for the use of the RNA, the composition or the vaccine as defined herein (for the preparation of an inventive vaccine) for the treatment (prophylaxis or therapy) of a disease or disorder as described herein. Such kits may further be applied for the use of the RNA, the composition or the vaccine as defined herein (for the preparation of an inventive vaccine) for modulating, preferably for eliciting, e.g. to induce or enhance, an immune response in a mammal as defined above, and preferably for supporting treatment (prophylaxis or therapy) of a disease or disorder as described herein. Kits of parts, as a special form of kits, may contain one or more identical or different compositions and/or one or more identical or different vaccines as described herein in different parts of the kit. Kits of parts may also contain an (e.g. one) composition, an (e.g. one) vaccine and/or the RNA according to the invention in different parts of the kit, e.g. each part of the kit containing an RNA as defined herein, preferably encoding a distinct antibody or distinct fragments of the same antibody. Preferably, the kit or the kit of parts contains as a part a vehicle for solubilising the RNA according to the invention, the vehicle preferably being Ringer-lactate solution. Any of the above kits may be used in a treatment or prophylaxis as defined above.

In a further embodiment, the kit according to the present invention may additionally contain at least one further pharmaceutically active component, preferably a therapeutic compound suitable for treatment (prophylaxis or therapy) of a disease or disorder as described herein. Moreover, in another embodiment, the kit may additionally contain parts and/or devices necessary or suitable for the administration of the composition or the vaccine according to the invention, including needles, applicators, patches, injection-devices.

Preferably, the kit according to the present invention contains, in particular as a part, Ringer-Lactate solution. It is also preferred that the kit according to the present invention contains, in particular as a part, at least one modulator of an inhibitory and/or a stimulatory checkpoint molecule, such as an inhibitor of an inhibitory checkpoint molecule, preferably CTLA4 inhibitors and PD-1 pathway inhibitors.

Moreover, in a particularly preferred embodiment, the kit according to the present invention contains, in particular as distinct parts, at least two distinct RNA's according to the present invention. Thereby, the details of the at least two distinct RNA's according to the present invention as described above, in the context of the combination for use according to the present invention, apply accordingly for the at least two distinct RNA's contained in the kit according to the present invention. Accordingly, it is preferred that one RNA of the at least two distinct RNA's encodes a heavy chain variable region of an antibody or a fragment thereof and another RNA of the at least two distinct RNA's encodes the corresponding light chain variable region of the antibody or the fragment thereof. More preferably, one RNA of the at least two distinct RNA's encodes a heavy chain of an antibody and another RNA of the at least two distinct RNA's encodes the corresponding light chain of the antibody. It is also preferred that the RNA encoding the heavy chain variable region or a fragment thereof and the RNA encoding the light chain variable region or a fragment thereof comprise identical 5′UTR elements and/or identical 3′UTR elements and/or identical further elements as described above, in the context of the combination for use according to the present invention.

Uses and methods according to the Present Invention

According to a further aspect of the present invention, the RNA, the combination of RNA's according to the present invention, the (pharmaceutical) composition, the (passive) vaccine or the kit according to the present invention may be used (for the preparation of a medicament) for the treatment (prophylaxis or therapy) of any disorder/disease, which can be treated by use of an antibody, in particular cancer, cardiovascular diseases, neurological diseases, infectious diseases, autoimmune diseases, virus diseases, monogenetic diseases and diseases or disorders related thereto. Preferably, the RNA, the combination of RNA's, the (pharmaceutical) composition, the (passive) vaccine or the kit according to the present invention may be used (for the preparation of a medicament) for the treatment (prophylaxis or therapy) of cancer or infectious diseases.

As used herein, the term “cancer” refers to the broad class of disorders and malignancies characterized by hyperproliferative cell growth, either in vitro (e.g., transformed cells) or in vivo. Conditions which can be treated or prevented by the compositions and methods of the invention include, e.g., a variety of neoplasms, including benign or malignant tumours, a variety of hyperplasias, or the like. Compositions and methods of the invention can achieve the inhibition and/or reversion of undesired hyperproliferative cell growth involved in such conditions. Specific examples of cancers to be treated in the context of the present invention include Acute Lymphoblastic Leukemia, Adult; Acute Lymphoblastic Leukemia, Childhood; Acute Myeloid Leukemia, Adult; Adrenocortical Carcinoma; Adrenocortical Carcinoma, Childhood; AIDS-Related Lymphoma; AIDS-Related Malignancies; Anal Cancer; Astrocytoma, Childhood Cerebellar; Astrocytoma, Childhood Cerebral; Bile Duct Cancer, Extrahepatic; Bladder Cancer; Bladder Cancer, Childhood; Bone Cancer, Osteosarcoma/Malignant Fibrous Histiocytoma; Brain Stem Glioma, Childhood; Brain Tumor, Adult; Brain Tumor, Brain Stem Glioma, Childhood; Brain Tumor, Cerebellar Astrocytoma, Childhood; Brain Tumor, Cerebral Astrocytoma/Malignant Glioma, Childhood; Brain Tumor, Ependymoma, Childhood; Brain Tumor, Medulloblastoma, Childhood; Brain Tumor, Supratentorial Primitive Neuroectodermal Tumors, Childhood; Brain Tumor, Visual Pathway and Hypothalamic Glioma, Childhood; Brain Tumor, Childhood (Other); Breast Cancer; Breast Cancer and Pregnancy; Breast Cancer, Childhood; Breast Cancer, Male; Bronchial Adenomas/Carcinoids, Childhood: Carcinoid Tumor, Childhood; Carcinoid Tumor, Gastrointestinal; Carcinoma, Adrenocortical; Carcinoma, Islet Cell; Carcinoma of Unknown Primary; Central Nervous System Lymphoma, Primary; Cerebellar Astrocytoma, Childhood; Cerebral Astrocytoma/Malignant Glioma, Childhood; Cervical Cancer; Childhood Cancers; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Chronic Myeloproliferative Disorders; Clear Cell Sarcoma of Tendon Sheaths; Colon Cancer; Colorectal Cancer, Childhood; Cutaneous T-Cell Lymphoma; Endometrial Cancer; Ependymoma, Childhood; Epithelial Cancer, Ovarian; Esophageal Cancer; Esophageal Cancer, Childhood; Ewing's Family of Tumors; Extracranial Germ Cell Tumor, Childhood; Extragonadal Germ Cell Tumor; Extrahepatic Bile Duct Cancer; Eye Cancer, Intraocular Melanoma; Eye Cancer, Retinoblastoma; Gallbladder Cancer; Gastric (Stomach) Cancer; Gastric (Stomach) Cancer, Childhood; Gastrointestinal Carcinoid Tumor; Germ Cell Tumor, Extracranial, Childhood; Germ Cell Tumor, Extragonadal; Germ Cell Tumor, Ovarian; Gestational Trophoblastic Tumor; Glioma. Childhood Brain Stem; Glioma. Childhood Visual Pathway and Hypothalamic; Hairy Cell Leukemia; Head and Neck Cancer; Hepatocellular (Liver) Cancer, Adult (Primary); Hepatocellular (Liver) Cancer, Childhood (Primary); Hodgkin's Lymphoma, Adult; Hodgkin's Lymphoma, Childhood; Hodgkin's Lymphoma During Pregnancy; Hypopharyngeal Cancer; Hypothalamic and Visual Pathway Glioma, Childhood; Intraocular Melanoma; Islet Cell Carcinoma (Endocrine Pancreas); Kaposi's Sarcoma; Kidney Cancer; Laryngeal Cancer; Laryngeal Cancer, Childhood; Leukemia, Acute Lymphoblastic, Adult; Leukemia, Acute Lymphoblastic, Childhood; Leukemia, Acute Myeloid, Adult; Leukemia, Acute Myeloid, Childhood; Leukemia, Chronic Lymphocytic; Leukemia, Chronic Myelogenous; Leukemia, Hairy Cell; Lip and Oral Cavity Cancer; Liver Cancer, Adult (Primary); Liver Cancer, Childhood (Primary); Lung Cancer, Non-Small Cell; Lung Cancer, Small Cell; Lymphoblastic Leukemia, Adult Acute; Lymphoblastic Leukemia, Childhood Acute; Lymphocytic Leukemia, Chronic; Lymphoma, AIDS—Related; Lymphoma, Central Nervous System (Primary); Lymphoma, Cutaneous T-Cell; Lymphoma, Hodgkin's, Adult; Lymphoma, Hodgkin's; Childhood; Lymphoma, Hodgkin's During Pregnancy; Lymphoma, Non-Hodgkin's, Adult; Lymphoma, Non-Hodgkin's, Childhood; Lymphoma, Non-Hodgkin's During Pregnancy; Lymphoma, Primary Central Nervous System; Macroglobulinemia, Waldenstrom's; Male Breast Cancer; Malignant Mesothelioma, Adult; Malignant Mesothelioma, Childhood; Malignant Thymoma; Medulloblastoma, Childhood; Melanoma; Melanoma, Intraocular; Merkel Cell Carcinoma; Mesothelioma, Malignant; Metastatic Squamous Neck Cancer with Occult Primary; Multiple Endocrine Neoplasia Syndrome, Childhood; Multiple Myeloma/Plasma Cell Neoplasm; Mycosis Fungoides; Myelodysplasia Syndromes; Myelogenous Leukemia, Chronic; Myeloid Leukemia, Childhood Acute; Myeloma, Multiple; Myeloproliferative Disorders, Chronic; Nasal Cavity and Paranasal Sinus Cancer; Nasopharyngeal Cancer; Nasopharyngeal Cancer, Childhood; Neuroblastoma; Neurofibroma; Non-Hodgkin's Lymphoma, Adult; Non-Hodgkin's Lymphoma, Childhood; Non-Hodgkin's Lymphoma During Pregnancy; Non-Small Cell Lung Cancer; Oral Cancer, Childhood; Oral Cavity and Lip Cancer; Oropharyngeal Cancer; Osteosarcoma/Malignant Fibrous Histiocytoma of Bone; Ovarian Cancer, Childhood; Ovarian Epithelial Cancer; Ovarian Germ Cell Tumor; Ovarian Low Malignant Potential Tumor; Pancreatic Cancer; Pancreatic Cancer, Childhood', Pancreatic Cancer, Islet Cell; Paranasal Sinus and Nasal Cavity Cancer; Parathyroid Cancer; Penile Cancer; Pheochromocytoma; Pineal and Supratentorial Primitive Neuroectodermal Tumors, Childhood; Pituitary Tumor; Plasma Cell Neoplasm/Multiple Myeloma; Pleuropulmonary Blastoma; Pregnancy and Breast Cancer; Pregnancy and Hodgkin's Lymphoma; Pregnancy and Non-Hodgkin's Lymphoma; Primary Central Nervous System Lymphoma; Primary Liver Cancer, Adult; Primary Liver Cancer, Childhood; Prostate Cancer; Rectal Cancer; Renal Cell (Kidney) Cancer; Renal Cell Cancer, Childhood; Renal Pelvis and Ureter, Transitional Cell Cancer; Retinoblastoma; Rhabdomyosarcoma, Childhood; Salivary Gland Cancer; Salivary Gland'Cancer, Childhood; Sarcoma, Ewing's Family of Tumors; Sarcoma, Kaposi's; Sarcoma (Osteosarcoma)/Malignant Fibrous Histiocytoma of Bone; Sarcoma, Rhabdomyosarcoma, Childhood; Sarcoma, Soft Tissue, Adult; Sarcoma, Soft Tissue, Childhood; Sezary Syndrome; Skin Cancer; Skin Cancer, Childhood; Skin Cancer (Melanoma); Skin Carcinoma, Merkel Cell; Small Cell Lung Cancer; Small Intestine Cancer; Soft Tissue Sarcoma, Adult; Soft Tissue Sarcoma, Childhood; Squamous Neck Cancer with Occult Primary, Metastatic; Stomach (Gastric) Cancer; Stomach (Gastric) Cancer, Childhood; Supratentorial Primitive Neuroectodermal Tumors, Childhood; T-Cell Lymphoma, Cutaneous; Testicular Cancer; Thymoma, Childhood; Thymoma, Malignant; Thyroid Cancer; Thyroid Cancer, Childhood; Transitional Cell Cancer of the Renal Pelvis and Ureter; Trophoblastic Tumor, Gestational; Unknown Primary Site, Cancer of, Childhood; Unusual Cancers of Childhood; Ureter and Renal Pelvis, Transitional Cell Cancer; Urethral Cancer; Uterine Sarcoma; Vaginal Cancer; Visual Pathway and Hypothalamic Glioma, Childhood; Vulvar Cancer; Waldenstrom's Macro globulinemia; and Wilms' Tumor.

Infectious diseases are typically caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi. Infectious diseases can usually be spread, directly or indirectly, from one person to another. Infectious diseases to be treated in the context of the present invention preferably include viral, retroviral, bacterial or protozoological infectious diseases. Specific examples of infectious diseases to be treated in the context of the present invention include influenza, malaria, SARS, yellow fever, AIDS, Lyme borreliosis, leishmaniasis, anthrax, meningitis, viral infectious diseases, such as AIDS, condyloma acuminata, molluscum contagiosum, dengue fever, three-day fever, Ebola virus, colds, early summer meningoencephalitis (ESME), influenza, shingles, hepatitis, herpes simplex type I, herpes simplex type II, herpes zoster, influenza, Japanese encephalitis, Lassa fever, Marburg virus, measles, foot and mouth disease, mononucleosis, mumps, Norwalk virus infection, Pfeiffer's glandular fever, smallpox, polio (poliomyelitis), pseuodcroup, infectious erythema, rabies, warts, West Nile fever, chicken-pox, cytomegalovirus (CMV), bacterial infectious diseases, such as abortion (infectious, septic), prostatitis (prostate inflammation), anthrax, appendicitis (inflammation of the caecum), borreliosis, botulism, Campylobacter, Chlamydia trachomatis (inflammation of the urethra, conjunctiva), cholera, diphtheria, donavonosis, epiglottitis, louse-borne typhus, typhoid fever, gas gangrene, gonorrhoea, hare plague, Helicobacter pylori, whooping-cough, climatic bubo, osteomyelitis, legionnaires' disease, leprosy, listeriosis, pneumonia, meningitis, bacterial meningitis, anthrax, inflammation of the middle ear, Mycoplasma hominis, neonatal sepsis (chorioamnionitis), noma, paratyphoid fever, plague, Reiter's syndrome, Rocky Mountain spotted fever, Salmonella paratyphoid fever, Salmonella typhoid fever, scarlet fever, syphilis, tetanus, gonorrhoea, tsutsugamushi fever, tuberculosis, typhus, vaginitis (colpitis), soft chancre, and infectious diseases caused by parasites, protozoa or fungi, such as amoebic dysentery, bilharziosis, Chagas' disease, Echinococcus, fish tapeworm, ichthyotoxism (ciguatera), fox tapeworm, mycosis pedis, dog tapeworm, candiosis, ptyriasis, the itch (scabies), cutaneous leishmaniasis, lamblian dysentery (giadiasis), lice, malaria, onchocercosis (river blindness), fungal diseases, beef tapeworm, schistosomiasis, sleeping sickness, pork tapeworm, toxoplasmosis, trichomoniasis, trypanosomiasis (sleeping sickness), visceral leishmaniasis, nappy dermatitis, or infections caused by the dwarf tapeworm.

The term “cardiovascular disease” as used herein typically includes any disorders/diseases of the cardiovascular system. Specific examples of cardiovascular diseases include coronary heart disease, arteriosclerosis, apoplexy and hypertension. The term “neurological disease” as used herein typically includes disorders/diseases of the nervous system. Specific examples of neurological diseases include Alzheimer's disease, amyotrophic lateral sclerosis, dystonia, epilepsy, multiple sclerosis and Parkinson's disease.

The term “autoimmune disease” as used herein typically refers to a pathological state rising from an abnormal immune response of the body to substances and tissues that are normally present in the body. Specific examples of autoimmune diseases include autoimmune type I diseases or autoimmune type II diseases or autoimmune type III diseases or autoimmune type IV diseases, such as, for example, multiple sclerosis (MS), rheumatoid arthritis, diabetes, diabetes type I (diabetes mellitus), systemic lupus erythematosus (SLE), chronic polyarthritis, Basedow's disease, autoimmune forms of chronic hepatitis, colitis ulcerosa, allergy type I diseases, allergy type II diseases, allergy type III diseases, allergy type IV diseases, fibromyalgia, hair loss, Bechterew's disease, Crohn's disease, myasthenia gravis, neurodermatitis, polymyalgia rheumatica, progressive systemic sclerosis (PSS), psoriasis, Reiter's syndrome, rheumatic arthritis, psoriasis or vasculitis.

It is particularly preferred that the RNA, the combination of RNA's according to the present invention, the (pharmaceutical) composition, the (passive) vaccine or the kit according to the present invention may be used (for the preparation of a medicament) for the treatment (prophylaxis or therapy) of any disorder/disease, which is related to the antibody, or the fragment thereof, encoded by the RNA. Particularly preferably, the antibody is any of the antibodies listed in Table 11 below. In this case, it is most preferred that the disease, disorder or condition to be treated and/or prevented is any disease, disorder or condition related to the antibody, in particular as described in Table 11 below.

TABLE 11 Antibodies, their targets and diseases, disorders or conditions related to the antibodies. Antibody Name Target Related Disease, Disorder or Condition AAB-003 Amyloid Beta Peptide; A beta P; Abeta; Beta Alzheimer's Disease Amyloid Abagovomab Tumour Antigen; CA-125 Epithelial Ovarian Cancer; Ovarian Cancer Abciximab Integrin Alpha 2b; GPalpha IIb; Platelet Ischemia; Percutaneous Coronary Intervention; Unstable Membrane Glycoprotein IIb; CD41; ITGA2B Angina Myocardial Infarction; Myocardial Ischemia; Percutaneous Coronary Intervention; Unstable Angina Abituzumab Integrin Alpha V; Vitronectin Receptor Subunit Interstitial Lung Diseases (Diffuse Parenchymal Lung Disease) Alpha; CD51; ITGAV Advanced Malignancy; Metastatic Cancer; Solid Tumor; Metastatic Colorectal Cancer; Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Ovarian Cancer; Cancer Abrilumab Integrin Alpha 4; CD49 Antigen Like Family Crohn's Disease (Regional Enteritis); Ulcerative Colitis; Member D; VLA4 Subunit Alpha; CD49d; ITGA4; Inflammatory Bowel Disease Integrin Beta 7; Gut Homing Receptor Beta Subunit; ITGB7; integrin α4β7 Actoxumab Clostridium difficile Toxin A; toxA; EC 3.4.22. Clostridium difficile Infections (Clostridium difficile Associated Disease); Clostridium difficile Colitis Adalimumab Tumor Necrosis Factor; Cachectin; TNF Alpha; Intermediate Uveitis; Posterior Uveitis; Uveitis Crohn's Tumor Necrosis Factor Ligand Superfamily Disease (Regional Enteritis); Ulcerative Colitis; Plaque Member 2; TNF a; TNF; TNFa; TNF-α Psoriasis (Psoriasis Vulgaris); Rheumatoid Arthritis; Ankylosing Spondylitis (Bekhterev's Disease); Polyarticular Juvenile Idiopathic Arthritis (PJIA); Crohn's Disease (Regional Enteritis); Psoriasis; Hidradenitis Suppurative; Axial Spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis (PJIA); Psoriatic Arthritis; Behcet Disease; Ulcerative Colitis; Polyarticular Juvenile Idiopathic Arthritis (PJIA); Interstitial Cystitis (Painful Bladder Syndrome); Ankylosing Spondylitis (Bekhterev's Disease); Axial Spondyloarthritis Spondyloarthritis (Spondyloarthropathy); Autoimmune Disease; Hemolytic disease of the newborn Adrecizumab Adrenomedullin Septic Shock Aducanumab Amyloid Beta Peptide; A beta P; Abeta; Beta Alzheimer's Disease Amyloid Afasevikumab Interleukin 17; IL17; IL17A; IL17F Autoimmune Disorders Aflibercept Placenta Growth Factor; Vascular Endothelial Age Related Macular Degeneration; Branch Retinal Vein Growth Factor Related Protein; PGF; Vascular Occlusion; Central Retinal Vein Occlusion; Macular Edema; Wet Endothelial Growth Factor A; Vascular (Neovascular/Exudative) Macular Degeneration; Choroidal Permeability Factor; VEGFA; Vascular Neovascularization; Myopia; Diabetic Macular Edema; Diabetic Endothelial Growth Factor B; VEGF Related Retinopathy; Central Retinal Vein Occlusion; Macular Edema; Factor; VEGFB Wet (Neovascular/Exudative) Macular Degeneration; Diabetic Macular Edema; Branch Retinal Vein Occlusion; Central Retinal Vein Occlusion; Choroidal Neovascularization; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Age Related Macular Degeneration; Central Retinal Vein Occlusion; Choroidal Neovascularization; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Branch Retinal Vein Occlusion; Central Retinal Vein Occlusion; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Branch Retinal Vein Occlusion; Central Retinal Vein Occlusion; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Branch Retinal Vein Occlusion; Central Retinal Vein Occlusion; Choroidal Neovascularization; Macular Edema; Myopia; Wet (Neovascular/Exudative) Macular Degeneration; Choroidal Neovascularization; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Age Related Macular Degeneration; Central Retinal Vein Occlusion; Choroidal Neovascularization; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Neovascular Glaucoma; Non-Proliferative Diabetic Retinopathy (NPDR); Optic Neuropathy; Retinopathy; Corneal Neovascularization Afutuzumab, B Lymphocyte Antigen CD20; B Lymphocyte Chronic Lymphocytic Leukemia (CLL); Follicular Lymphoma; Obinutuzumab Surface Antigen B1; Bp35; Leukocyte Surface Non-Hodgkin Lymphoma; Lupus Nephritis; Diffuse Large B-Cell Antigen Leu 16; Membrane Spanning 4 Lymphoma; Follicular Lymphoma; Splenic Marginal Zone B-Cell Domains Subfamily A Member 1; CD20; MS4A1 Lymphoma; End-Stage Kidney Disease (End-Stage Renal Disease; ESRD); Graft Versus Host Disease (GVHD); Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL) Waldenstrom Macroglobulinemia; Diffuse Large B-Cell Lymphoma; Alacizumab, Vascular Endothelial Growth Factor Receptor Non-Small Cell Lung Cancer Alacizumab 2; Fetal Liver Kinase I; Kinase Insert Domain pegol Receptor; Protein Tyrosine Kinase Receptor flk 1; VEGFR2; CD309; KDR; EC 2.7.10.1 Alemtuzumab CAMPATH 1 Antigen; CDw52; Cambridge Progressive Relapsing Multiple Sclerosis (PRMS); Relapsing Pathology 1 Antigen; Epididymal Secretory Remitting Multiple Sclerosis (RRMS); B-Cell Chronic Protein E5; Human Epididymis Specific Lymphocytic Leukemia; Peripheral T-Cell Lymphomas (PTCL); Protein 5; CD52 T-Cell Leukemia Graft Versus Host Disease (GVHD); B-Cell Chronic Lymphocytic Leukemia; Mycosis Fungoides; Sezary Syndrome Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL); Multiple Sclerosis Alirocumab Proprotein Convertase Subtilisin/Kexin Type Heterozygous familial hypercholesterolemia (heFH); 9; Proprotein Convertase 9; Neural Apoptosis Hypercholesterolemia; Mixed Dyslipidemia Familial Regulated Convertase 1; Subtilisin/Kexin Like Hypercholesterolemia (Type II Hyperlipoproteinemia); Protease PC9; PCSK9; EC 3.4.21. Hypercholesterolemia ALX-0061, Interleukin 6 Receptor; IL6R Rheumatoid Arthritis; Systemic Lupus Erythematosus vobarilizumab Amatuximab Mesothelin; CAKI Antigen; Pre Pro Malignant Pleural Mesothelioma; Non-Small Cell Lung Cancer; Megakaryocyte Potentiating Factor; MSLN Ovarian Cancer; Pancreatic Cancer Andecaliximab MMP9; matrix metallopeptidase 9 Gastroesophageal Junction Adenocarcinoma; Gastric Adenocarcinoma Anetumab, Mesothelin; CAKI Antigen; Pre Pro Lung Adenocarcinoma; Malignant Pleural Mesothelioma Anetumab Megakaryocyte Potentiating Factor; MSLN Advanced Malignancy; Solid Tumor Bile Duct Cancer ravtansine (Cholangiocarcinoma); Breast Cancer; Colon Cancer; Endometrial Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Gastroesophageal (GE) Junction Carcinomas; Metastatic Pancreatic Cancer; Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Peritoneal Cancer; Thymic Carcinoma; Uterine Cancer Anifrolumab Interferon Alpha/Beta Receptor 1; Cytokine Systemic Lupus; Erythematosus Systemic Sclerosis Receptor Class II Member 1; Cytokine (Scleroderma) Receptor Family 2 Member 1; Type I Interferon Receptor 1; IFNAR1 Anrukinzumab, Interleukin 13; IL13 Asthma; Ulcerative Colitis IMA-638 Apolizumab HLA-DR Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); Chronic Lymphocytic Leukemia (CLL); Non-Hodgkin Lymphoma; Hematological Cancers Apomab Death receptor 5; DR5/TNF-related apoptosis Cancer inducing ligand-receptor 2; TRAIL-R2. Aprutumab FGFR2 low blood neutrophils; Neutropenia; Febrile Neutropenia; Chemotherapy Induced Neutropenia; Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia) Aquaporumab Aquaporin-4; AQP4 Acute and Chronic Management of Neuromyelitis Optica Spectrum Disorder Arcitumomab Carcinoembryonales Antigen; CEA Diagnostic Imaging of Colorectal Cancers; Gastrointestinal Cancers (Diagnosis) Ascrinvacumab Serine/Threonine Protein Kinase Receptor Malignant Pleural Mesothelioma; Metastatic Colorectal Cancer; R3; Activin Receptor Like Kinase 1; TGF B Transitional Cell Carcinoma (Urothelial Cell Carcinoma); Superfamily Receptor Type I; ALK1; ACVRL1; EC Hepatocellular Carcinoma 2.7.11.30 Aselizumab L-Selectin; CD62L Chronic Lymphocytic Leukemia (CLL);; Chronic Obstructive Pulmonary Disease (COPD); Inflammatory Bowel Disease; Vaso-Occlusive Crisis Associated With Sickle Cell Disease Atezolizumab Programmed Cell Death I Ligand 1; PD L1; B7 Metastatic Transitional (Urothelial) Tract Cancer; Non-Small Homolog 1; CD274 Cell Lung Cancer; Transitional Cell Carcinoma (Urothelial Cell Carcinoma) Bladder Cancer; Transitional Cell Carcinoma (Urothelial Cell Carcinoma) Epithelial Ovarian Cancer; Fallopian Tube Cancer; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Metastatic Melanoma; Muscle Invasive Bladder Cancer (MIBC); Non-Small Cell Lung Cancer; Peritoneal Cancer; Renal Cell Carcinoma; Small-Cell Lung Cancer; Squamous Non-Small Cell Lung Cancer Bladder Cancer; Breast Cancer; Muscle Invasive Bladder Cancer (MIBC); Non-Small Cell Lung Carcinoma; Renal Cell Carcinoma; Small-Cell Lung Cancer; Transitional Cell Cancer (Urothelial Cell Cancer) Cervical Cancer; Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Metastatic Colorectal Cancer; Non Muscle Invasive Bladder Cancer (NMIBC) (Superficial Bladder Cancer); Non-Small Cell Lung Cancer; Soft Tissue Sarcoma; Solid Tumor; Uterine Cancer Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); Adenocarcinoma Of The Gastroesophageal Junction; Breast Cancer; Chronic Lymphocytic Leukemia (CLL); Diffuse Large B- Cell Lymphoma; Esophageal Cancer; Follicular Lymphoma; Gastric Cancer; Hepatocellular Carcinoma; Malignant Pleural Mesothelioma; Merkel Cell Carcinoma; Metastatic Melanoma; Metastatic Pancreatic Cancer; Multiple Myeloma (Kahler Disease); Myelodysplastic Syndrome; Nasopharyngeal Cancer; Neuroendocrine Gastroenteropancreatic Tumors (GEP-NET); Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Acute Myeloid Leukemia; Relapsed Chronic Lymphocytic Leukemia (CLL) Atinumab Reticulon 4; Human NogoA; Neurite Outgrowth Acute Spinal Cord Injury Inhibitor; Foocen; Neuroendocrine Specific Protein; Neuroendocrine Specific Protein C Homolog; RTN x; Reticulon 5; RTN4 Atlizumab, IL6 receptor rheumatoid arthritis; Crohn's disease; multiple myeloma and Tocilizumab the lymphoproliferative disorder giant lymph node hyperplasia (Castleman's disease). Aurograb Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus (MRSA) Infections Avelumab Programmed Cell Death 1 Ligand 1; PD L1; B7 Merkel Cell Carcinoma; Metastatic Transitional (Urothelial) Homolog 1; CD274 Tract Cancer; Bladder Cancer; Diffuse Large B-Cell Lymphoma; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Gastric Cancer; Gastroesophageal (GE) Junction Carcinomas; Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Renal Cell Carcinoma; Metastatic Transitional (Urothelial) Tract Cancer; Non-Small Cell Lung Cancer; Ovarian Cancer; Peritoneal Cancer Choriocarcinoma (Gestational Trophoblastic Neoplasia); Epithelial Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer; Thymic Carcinoma; Thymoma (Thymic Epithelial Tumor) Adenocarcinoma Of The Gastroesophageal Junction; Gastric Cancer Adrenocortical Carcinoma (Adrenal Cortex Cancer); Breast Cancer; Endometrial Cancer; Fallopian Tube Cancer; Glioblastoma Multiforme (GBM); Head and Neck Cancer Squamous Cell Carcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Malignant Mesothelioma; Melanoma; Metastatic Cancer; Metastatic Colorectal Cancer; Nasopharyngeal Cancer; Osteosarcoma; Peritoneal Cancer; Renal Cell Carcinoma; Solid Tumor Leiomyosarcoma; Liposarcoma; Refractory Acute Myeloid Leukemia; Relapsed Acute Myeloid Leukemia Azintuxizumab SLAMF7 Multiple Myeloma (Kahler Disease); Refractory Multiple Myeloma; Relapsed Multiple Myeloma; B-Cell Chronic Lymphocytic Leukemia Bapineuzumab Amyloid Beth Peptide; A beta P; Abeta; Beta Alzheimer's Disease Amyloid Basiliximab Interleukin 2 Receptor Subunit Alpha; TAC Inflammatory Bowel Disease; Ulcerative Colitis; Uveitis; Kidney Antigen; p55; CD25; IL2RA Transplant Rejection Bavituximab Phosphatidylserine Hepatocellular Carcinoma Adenocarcinoma; Rectal Cancer Ebolavirus Infections (Ebola Hemorrhagic Fever); Hemorrhagic Fever; Unspecified Influenza Virus Infections Hepatitis C Melanoma; Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Pancreatic Cancer Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Non-Small Cell Lung Cancer Begelomab Dipeptidyl Peptidase 4; ADABP; Adenosine Graft Versus Host Disease (GVHD) Deaminase Complexing Protein 2; T Cell Activation Antigen CD26; TP103; CD26; DPP4; EC 3.4.14.5 Belimumab Tumor Necrosis Factor Ligand Superfamily Systemic Lupus Erythematosus; Polymyositis/Idiopathic Member 13B; B Lymphocyte Stimulator; Inflammatory Myopathy; Microscopic Polyangiitis (MPA); Anti- Dendritic Cell Derived TNF Like Molecule; TNF Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA and APOL Related Leukocyte Expressed Ligand Vasculitis); Granulomatosis with Polyangiitis (Wegener 1; CD257; TNFSF13B Polyangiitis); Lupus Nephritis; Membranous Glomerulonephritis; Kidney Transplant Rejection; Myasthenia Gravis; Sicca Syndrome (Sjogren); Systemic Sclerosis (Scleroderma); Idiopathic Thrombocytopenic Purpura (Immune Thrombocytopenic Purpura); Rheumatoid Arthritis Waldenstrom Macroglobulinemia Benralizumab Interleukin 5 Receptor Subunit Alpha; IL 5 Asthma Chronic Obstructive Pulmonary Disease (COPD); Receptor Subunit Alpha; CDw125; CD125; IL5RA Rhinosinusitis; Hypereosinophilic Syndrome; Granulomatosis with Polyangiitis (Wegener Polyangiitis) Bertilimumab Eotaxin; C-C Motif Chemokine II; Eosinophil Atopic Dermatitis; Bullous Pemphigoid; Crohn's Disease Chemotactic Protein; Small Inducible Cytokine (Regional Enteritis); Non-Alcoholic Steatohepatitis; Ulcerative All; CCLII Colitis; Atopic Keratoconjunctivitis; Vernal Keratoconjunctivitis; Wet (Neovascular/Exudative) Macular Degeneration; Primary Sclerosing Cholangitis; Psoriasis; Asthma; Betalutin Leukocyte Antigen CD37; Tetraspanin 26; Follicular Lymphoma; Mantle Cell Lymphoma; Marginal Zone B- CD37 cell Lymphoma; Diffuse Large B-Cell Lymphoma Bevacizumab, Vascular endothelial growth factor; VEGF; Breast Cancer; Cervical Cancer; Epithelial Ovarian Cancer; Bevacizumab VEGF-A Fallopian Tube Cancer; Metastatic Ovarian Cancer; Metastatic beta, Renal Cell Carcinoma; Peritoneal Cancer Colorectal Cancer; Bevacizumab- Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Glioma; rhuMAb-VEGF, Renal Cell Carcinoma Colorectal Cancer; Metastatic Breast Bevacituzuab Cancer; Non-Small Cell Lung Cancer; Metastatic Colorectal Cancer; Ovarian Cancer; Cervical Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Glioblastoma Multiforme (GBM); Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Peritoneal Cancer; Breast Cancer; Cervical Cancer; Colorectal Cancer; Glioblastoma Multiforme (GBM); Malignant Glioma; Non-Small Cell Lung Cancer; Ovarian Cancer Lung Cancer; Metastatic Colorectal Cancer; Cervical Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Malignant Glioma; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Peritoneal Cancer; Cervical Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Metastatic Colorectal Cancer; Peritoneal Cancer; Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Fallopian Tube Cancer; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Peritoneal Cancer; Glioma; Metastatic Breast Cancer; Non- Small Cell Lung Cancer; Cervical Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Metastatic Colorectal Cancer; Peritoneal Cancer; Cervical Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma; Non- Small Cell Lung Cancer; Peritoneal Cancer; Glioblastoma Multiforme (GBM); Malignant Pleural Mesothelioma; Metastatic Breast Cancer; Renal Cell Carcinoma; Neuroblastoma; Oligodendroglioma; Malignant Pleural Mesothelioma; Merkel Cell Carcinoma; Nasopharyngeal Cancer; Bladder Cancer; Chronic Lymphocytic Leukemia (CLL); Diffuse Large B-Cell Lymphoma; Metastatic Liver Cancer; Non-Rhabdomyosarcoma; Rhabdomyosarcoma; Small-Cell Lung Cancer; Gastrointestinal Tumor; Meningioma; Metastatic Melanoma; Metastatic Pancreatic Cancer; Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Breast Cancer; Neuroendocrine Tumors; Non-Small Cell Lung Cancer; Cancer Bezlotoxumab Clostridium difficile Toxin B; toxB; EC 3.4.22. Clostridium difficile Infections (Clostridium difficile Associated Disease) Bimagrumab Activin Receptor Type 2B; ACVR2B; EC Type 2 Diabetes; Bone Fracture; Sarcopenia; Cachexia; Cancer 2.7.11.30 Anorexia-Cachexia Syndrome; Sporadic Inclusion Body Myositis (s-IBM) Bimekizumab Interleukin 17A; Cytotoxic T Lymphocyte Ulcerative Colitis; Plaque Psoriasis (Psoriasis Vulgaris); Associated Antigen 8; CTLA8; IL17A; Interleukin Rheumatoid Arthritis; Ankylosing Spondylitis (Bekhterev's 17F; Cytokine ML 1; IL17F Disease); Psoriatic Arthritis Bleselumab Tumor Necrosis Factor Receptor Superfamily Kidney Transplant Rejection; Plaque Psoriasis (Psoriasis Member 5; B Cell Surface Antigen CD40; Vulgaris) Bp50; CDw40; CD40L Receptor; TNFRSF5; CD40 Blinatumomab, B Lymphocyte Antigen CD19; B Lymphocyte Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Blinatumumab Surface Antigen B4; Differentiation Antigen Leukemia); Extranodal Marginal Zone B-Cell Lymphoma CD19; T Cell Surface Antigen Lau 12; CD19; T (Mucosa-Associated Lymphoid Tissue; MALT-Lymphoma); Cell Surface Glycoprotein CD3 Epsilon Chain; Follicular Lymphoma; Nodal Marginal Zone B-Cell Lymphoma; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; Splenic Marginal Zone B-Cell Lymphoma; Acute Lymphocytic CD3E; CD3 Leukemia (ALL; Acute Lymphoblastic Leukemia); Diffuse Large B-Cell Lymphoma; B-Cell Chronic Lymphocytic Leukemia; Hairy Cell Leukemia; Mantle Cell Lymphoma; Blontuvetmab Beth 2 Glycoprotein 1; APC Inhibitor; Activated Infectious Disease; Oncology Protein C Binding Protein; Anticardiolipin Cofactor; Apolipoprotein H; APOH; Phosphatidylserine Blosozumab Sclerostin; SOST Post Menopausal Osteoporosis Bococizumab Proprotein Convertase Subtilisin/Kexin Type Hyperlipidemia; Heterozygous familial hypercholesterolemia 9; Proprotein Convertase 9; Neural Apoptosis (heFH); Mixed Dyslipidemia; Atherosclerosis; Post Acute Regulated Convertase 1; Subtilisin/Kexin Like Coronary Syndrome Protease PC9; PCSK9; EC 3.4.21. Brazikumab Interleukin 23; IL23 Crohn's Disease (Regional Enteritis); Psoriasis Brentuximab, Tumor Necrosis Factor Receptor Superfamily Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Mycosis Brentuximab Member 8; CD30L Receptor; Ki 1 Antigen; Fungoides; Anaplastic Large Cell Lymphoma (ALCL); Cutaneous vedotin Lymphocyte Activation Antigen CD30; CD30; T-Cell Lymphoma; Mycosis Fungoides; Hodgkin Lymphoma (B- TNFRSF8 Cell Hodgkin Lymphoma); T-Cell Lymphomas; Systemic Mastocytosis; Diffuse Large B-Cell Lymphoma; Mast Cell Leukemia; Systemic Lupus Erythematosus; Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); Anaplastic Large Cell Lymphoma (ALCL); Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy; Diffuse Large B-Cell Lymphoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Lymphoma; Mycosis Fungoides; Peripheral T-Cell Lymphomas (PTCL); Solid Tumor; T-Cell Leukemia; Malignant Mesothelioma; Graft Versus Host Disease (GVHD); Anaplastic Large Cell Lymphoma (ALCL); Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma) Briakinumab Interleukin 12 Subunit Beta; Cytotoxic Multiple Sclerosis; Crohn's Disease (Regional Enteritis); Plaque Lymphocyte Maturation Factor 40 kDa Psoriasis (Psoriasis Vulgaris) Subunit; CLMF p40; IL12 Subunit p40 NK Cell Stimulatory Factor Chain 2; IL12B Brodalumab Interleukin 17 Receptor; IL17R Plaque Psoriasis (Psoriasis Vulgaris); Psoriatic Arthritis; Axial Spondyloarthritis; Crohn's Disease (Regional Enteritis); Rheumatoid Arthritis; Asthma Brolucizumab Vascular Endothelial Growth Factor A; Diabetic Macular Edema; Wet (Neovascular/Exudative) Vascular Permeability Factor; VEGFA Macular Degeneration; Keloids; Rosacea; Kaposi Sarcoma; Glioblastoma Multiforme (GBM) Brontictuzumab Neurogenic Locus Notch Homolog Protein 1; Adenoid Cystic Carcinoma (ACC); Bile Duct Cancer Translocation Associated Notch Protein TAN 1; (Cholangiocarcinoma); Breast Cancer; Esophageal Cancer; NOTCH1 Gastric Cancer; Metastatic Colorectal Cancer; Pancreatic Cancer; Small-Cell Lung Cancer; Solid Tumor; Hematological Tumor BTT-ID23, Membrane Primary Amine Oxidase; Copper Primary Sclerosing Cholangitis; Inflammatory Bowel Disease; Timolumab Amine Oxidase; Semicarbazide-Sensitive Neurology; Psoriasis; Rheumatoid Arthritis; Plaque Psoriasis Amine Oxidase; Vascular Adhesion Protein 1; (Psoriasis Vulgaris); Rheumatoid Arthritis HPAO; ADO3; EC 1.4.3.21 Burosumab Fibroblast Growth Factor 23; Phosphatonin; X-Linked Hypophosphatemic Rickets; Osteomalacia Tumor Derived Hypophosphatemia Inducing Factor; FGF23 Cabiralizumab Macrophage Colony Stimulating Factor 1 Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Receptor; CSF 1 Receptor; Proto Oncogene c Tumor; Glioblastoma Multiforme (GBM); Head and Neck Cancer Fms; CD115; CSFIR; EC 2.7.10.1 Squamous Cell Carcinoma; Melanoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Renal Cell Carcinoma; Colorectal Cancer; Rheumatoid Arthritis Camrelizumab PDCD1 Solid tumours Breast cancer Melanoma Canakinumab Interleukin 1 Beta; IL 1 Beta; Catabolin; IL1B Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Mevalonate Kinase Deficiency (Hyperimmunoglobulin D Syndrome (HIDS)); Muckle-Wells Syndrome; Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (Familial Hibernian Fever); Systemic Idiopathic Juvenile Arthritis; Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle- Wells Syndrome; Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (Familial Hibernian Fever); Familial Mediterranean Fever; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease; Systemic Idiopathic Juvenile Arthritis; Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease; Cryopyrin- Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle- Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease; Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease; Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-Wells Syndrome; Gouty Arthritis (Gout); Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-Wells Syndrome; Neonatal Onset Multisystem Inflammatory Disease; Cryopyrin-Associated Periodic Syndromes; Familial Cold Autoinflammatory Syndrome (Familial Cold Urticaria); Muckle-Wells Syndrome Systemic Idiopathic Juvenile Arthritis; Mevalonate Kinase Deficiency (Hyperimmunoglobulin D Syndrome (HIDS)); Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (Familial Hibernian Fever); Familial Mediterranean Fever; Systemic Idiopathic Juvenile Arthritis; Cardiovascular Risk Factors; Behcet Disease; Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD); Sarcoidosis; Pain; Abdominal Aortic Aneurysms; Polymyalgia Rheumatica; Mucocutaneous Lymph Node Syndrome (Kawasaki Disease); Choroidal Neovascularization; Keratoconjunctivitis sicca (Dry Eye); Chronic Obstructive Pulmonary Disease (COPD); Vasculitis; Rheumatoid Arthritis; Type I Diabetes (Juvenile Diabetes); Type 2 Diabetes; Gouty Arthritis (Gout) Cantuzumab, CanAg antigen; Mucin CanAg Colorectal Cancer; Gastric Cancer; Non-Small Cell Lung Cantuzumab Cancer; Pancreatic Cancer mertansine Cantuzumab, CanAg antigen; MUCI Colorectal Cancer; Gastric Cancer; Gastroesophageal (GE) Cantuzumab Junction Carcinomas; Non-Small Cell Lung Cancer; Pancreatic ravtansine Cancer; Solid Tumor Caplacizumab Von Willebrand Factor; VWF Thrombotic Thrombocytopenic Purpura; Acute Coronary Syndrome Carlumab C-C chemokine ligand 2 Inflammatory Bowel Disease; Ovarian Cancer; Solid Tumor; Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Pancreatic Cancer; Idiopathic Pulmonary Fibrosis Catumaxomab CD3; Epithelial Cell Adhesion Molecule; Ascites; Adenocarcinoma Of The Gastroesophageal Junction; Adenocarcinoma Associated Antigen; Cell Peritoneal Cancer; Epithelial Ovarian Cancer; Epithelial Tumor Surface Glycoprotein Trop 1; Epithelial Cell Surface Antigen; Epithelial Glycoprotein 314; KS ¼ Antigen; KSA; Tumor Associated Calcium Signal Transducer 1; CD326; EPCAM Cergutuzumab, Interleukin 2 Receptor; IL2R Solid Tumor Cergutuzumab amunaleukin Certolizumab, Tumor Necrosis Factor; Cachectin; TNF Alpha; Rheumatoid Arthritis; Ankylosing Spondylitis (Bekhterev's Certolizumab Tumor Necrosis Factor Ligand Superfamily Disease); Axial Spondyloarthritis; Psoriatic Arthritis; Plaque pegol Member 2; TNF a; TNF Psoriasis (Psoriasis Vulgaris); Crohn's Disease (Regional Enteritis) Cetuximab, Epidermal Growth Factor Receptor; Proto Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Erbitux Oncogene c ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Recurrent Head and Neck Cancer Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Squamous Cell Carcinoma; Metastatic Colorectal Cancer; Chronic Pain; Neuropathic Pain; Adenocarcinoma Of The Gastroesophageal Junction; Gastric Cancer; Metastatic Biliary Tract Cancer; Prostate Cancer; Fallopian Tube Cancer; Metastatic Pancreatic Cancer; Ovarian Cancer; Peritoneal Cancer; Non-Small Cell Lung Cancer; Pancreatic Cancer; Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Squamous Cell Carcinoma Citatuzumab, Epithelial Cell Adhesion Molecule; Solid Tumor Citatuzumab Adenocarcinoma Associated Antigen; Cell bogatox Surface Glycoprotein Trop 1; Epithelial Cell Surface Antigen; Epithelial Glycoprotein 314; KS ¼ Antigen; KSA; Tumor Associated Calcium Signal Transducer 1; CD326; EPCAM Cixutumumab Insulin Like Growth Factor 1 Receptor; CD221; Carcinomas; Colon Cancer; Rectal Cancer; Advanced IGFIR; EC 2.7.10.1 Malignancy; Ewing Sarcoma; Head and Neck Cancer Squamous Cell Carcinoma; Hepatocellular Carcinoma; Islet Cell Carcinoma (Insulinoma); Leiomyosarcoma; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Hepatocellular Carcinoma (HCC); Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Metastatic Pancreatic Cancer; Neuroendocrine Tumors; Non-Small Cell Lung Cancer; Primitive Neuroectodermal Tumor (PNET); Rhabdomyosarcoma; Sarcomas; Soft Tissue Sarcoma Clazakizumab Interleukin 6; B Cell Stimulatory Factor 2; Rheumatoid Arthritis; Psoriatic Arthritis; Fatigue; Crohn's BSF2; CTL Differentiation Factor; CDF; Disease (Regional Enteritis); Oral Mucositis; Anemia; Graft Hybridoma Growth Factor; Interferon Beta 2; Versus Host Disease (GVHD); Cancer Anorexia-Cachexia IFNB2; IL6 Syndrome Clivatuzumab, Mucin 1; Breast Carcinoma Associated Antigen Metastatic Pancreatic Cancer; Pancreatic Cancer Clivatuzumab DF3; Episialin; H23AG; Krebs Von Den Lungen tetraxetan, 6; PEMT: Peanut Reactive Urinary Mucin; Yttrium (90Y) Polymorphic Epithelial Mucin; Tumor clivatuzumab Associated Epithelial Membrane Antigen; tetraxetan Tumor Associated Mucin; CD227; MUC1 Codrituzumab Glypican 3; Heparan Sulphate Proteoglycan; Metastatic Hepatocellular Carcinoma (HCC) Intestinal Protein DCI 5; GTR2 2; MXR7; GPC3 Coltuximab B Lymphocyte Antigen CD19; B Lymphocyte Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic ravtansine Surface Antigen B4; Differentiation Antigen Leukemia); Diffuse Large B-Cell Lymphoma CD19; T Cell Surface Antigen Leu 12; CD19 Conatumumab Tumor Necrosis Factor Receptor Superfamily Colorectal Cancer; Lymphoma; Metastatic Cancer; Metastatic Member 10B; Death Receptor 5; TNF Related Colorectal Cancer; Metastatic Pancreatic Cancer; Apoptosis Inducing Ligand Receptor 2; TRAIL Neuroendocrine Tumors; Non-Hodgkin Lymphoma; Non-Small Receptor 2; DRS; CD262; TNFRSF108 Cell Lung Cancer; Sarcomas; Soft Tissue Sarcoma; Solid Tumor; Non-Small Cell Lung Cancer; Solid Tumor Concizumab Tissue Factor Pathway Inhibitor; Extrinsic Hemophilia A; Hemophilia B Pathway Inhibitor; EPI; Lipoprotein Associated Coagulation Inhibitor; LACI; TFPI Cosfroviximab Ebolavirus glycoprotein Ebola virus infections Crenezumab Amylaid Beta Peptide; A beta P; Abate; Beta Alzheimer's Disease Amyloid Crizanlizumab P Selectin; CD62 Antigen Like Family Member Vaso-Occlusive Crisis Associated With Sickle Cell Disease; P; Granule Membrane Protein 140; Leukocyte Sickle Cell Disease Endothelial Cell Adhesion Molecule 3; LECAM3; Platelet Activation Dependent Granule External Membrane Protein; CD62P; SELP Crotedumab Glucagon Receptor; GL R; GCGR Type 2 Diabetes Dacetuzumab Tumor Necrosis Factor Receptor Superfamily Multiple Myeloma (Kehler Disease); Chronic Lymphocytic Member 5; B Cell Surface Antigen CD40; Leukemia (CLL); Diffuse Large B-Cell Lymphoma; B-Cell Non- Bp50; CDw40; CD40L Receptor; TNFRSF5; Hodgkin Lymphoma CD40 Dacliximab Interleukin 2 Receptor Subunit Alpha; TAC Relapsing Remitting Multiple Sclerosis (RRMS); Ulcerative Antigen; p55; CD25; IL2RA Colitis; Kidney Transplant Rejection Daclizumab Interleukin 2 Receptor Subunit Alpha; TAC Relapsing Remitting Multiple Sclerosis (RRMS); Ulcerative Antigen; p55; CD25; IL2RA Colitis; Kidney Transplant Rejection Dalotuzumab Insulin Like Growth Factor I Receptor; CD221; Metastatic Breast Cancer; Pancreatic Cancer; Metastatic IGFIR; EC 2.7.10.1 Colorectal Cancer; Multiple Myeloma (Kehler Disease); Neuroendocrine Tumors; Non-Small Cell Lung Cancer Dapirolizumab, CD40 Ligand; T Cell Antigen Gp39; TNF Related Amyotrophic Lateral Sclerosis; Systemic Lupus Erythematosus Dapirolizumab Activation Protein; Tumor Necrosis Factor pegal Ligand Superfamily Member 5; CD154; CD40LG; CD40L Daratumumab ADP Ribosyl Cyclase/Cyclic ADP Ribose Multiple Myeloma (Kehler Disease); Refractory Multiple Hydrolase 1; Cyclic ADP Ribose Hydrolase 1; Myeloma; Amyloidosis; Diffuse Large B-Cell Lymphoma; T10; 2′ Phospho ADP Ribosyl Cyclase/2′ Follicular Lymphoma; Mantle Cell Lymphoma; Myelodysplastic Phospho Cyclic ADP Ribose Transferase; ADP Syndrome; Non-Small Cell Lung Cancer; Multiple Myeloma Ribosyl Cyclase 1; CD3B; EC 3.2.2.6; EC (Kehler Disease); Natural Killer Cell Lymphomas; Refractory 2.4.99.20 Acute Myeloid Leukemia; Relapsed Acute Myeloid Leukemia; T- Cell Lymphomas; Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); Chronic Lymphocytic Leukemia (CLL); Prostate Cancer Dectrekumab Interleukin 13; IL13; Lymphedema; Asthma; Eosinophilic Esophagitis; Anal Fistula; Asthma; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Seasonal Allergic Rhinitis Demcizumab Delta Like Protein 4; Delta Like Ligand 4; Fallopian Tube Cancer; Non-Small Cell Lung Cancer; Ovarian Drosophila Delta Homolog 4; DLL4 Cancer; Pancreatic Ductal Adenocarcinoma; Peritoneal Cancer; Metastatic Colorectal Cancer; Solid Tumor; Breast Cancer; Colon Cancer Denintuzumab, Expressing B Lymphocyte Antigen CD19; B Burkitt Lymphoma; Acute Lymphocytic Leukemia (ALL; Acute Denintuzumab Lymphocyte Surface Antigen B4; Lymphoblastic Leukemia); B-Cell Non-Hodgkin Lymphoma; mafodotin Differentiation Antigen CD19; T Cell Surface Lymphoblastic Lymphoma; Mantle Cell Lymphoma; Follicular Antigen Leu 12; CD19 Lymphoma; Diffuse Large B-Cell Lymphoma Denosumab Tumor Necrosis Factor Ligand Superfamily Humoral Hypercalcemia of Malignancy; Bone Metastasis; Giant Member II; Receptor Activator Of Nuclear Cell Tumor Of Bone; Humoral Hypercalcemia of Malignancy; Factor Kappa B Ligand; Osteoclast Osteoporosis; Post Menopausal Osteoporosis; Chemotherapy Differentiation Factor; TNF Related Activation Effects; Rheumatoid Arthritis; Osteogenesis Imperfecta; Bone Induced Cytokine; Osteoprotegerin Ligand; Disorders; Bone Metastasis; Glucocorticoid-Induced CD254; TNFSF11 Osteoporosis; Non-Small Cell Lung Cancer; Breast Cancer; Osteoarthritis; Metastatic Breast Cancer Depatuxizumab, Epidermal Growth Factor Receptor; Proto Glioma; Colorectal Cancer; Glioblastoma Multiforme (GBM); Depatuxizumab Oncogene c ErbB 1; Receptor Tyrosine Protein Head and Neck Cancer Squamous Cell Carcinoma; Non-Small mafodotin Kinase erbB1; HER1; ERBB1; EGFR; EC 2.7.10.1 Cell Lung Cancer; Solid Tumor Derlotuximab, histone complex Glioma; Anaplastic Astrocytoma; Glioblastoma Multiforme Iodine (1311) (GBM) derlotuximab biotin Dezamizumab Serum Amyloid Protein; SAP Amyloidosis Dinutuximab Ganglioside GD2 Neuroblastoma; Osteosarcoma Dinutuximabbeta Ganglioside GD2 Neuroblastoma Diridavumab Hemagglutinin Influenza A Virus; H5N1 Subtype Infections; Pandemic Influenza Domagrozumab Growth/Differentiation Factor 8; Myostatin; Duchenne Muscular Dystrophy; Muscular Dystrophy; Becker GDF8; MSTN Muscular Dystrophy Drozitumab, Tumor Necrosis Factor Receptor Superfamily Non-Small Cell Lung Cancer; Follicular Lymphoma; Colorectal Drozituab Member 10B; Death Receptor 5; TNF Related Cancer; Lymphoma; Non-Hodgkin Lymphoma; Apoptosis Inducing Ligand Receptor 2; TRAIL Chondrosarcoma; Metastatic Colorectal Cancer; Cancer Receptor 2; DR5; CD262; TNFRSF10B Duligotuzumab, Epidermal Growth Factor Receptor; Proto Non-Small Cell Lung Cancer; Epithelial Tumor; Metastatic Duligotumab Oncogene c ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Recurrent Head and Neck Cancer; Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1; Squamous Cell Carcinoma; Testicular Cancer Receptor Tyrosine Protein Kinase ERBB 3; Proto Oncogene Like Protein c ErbB 3; Tyrosine Kinase Type Cell Surface Receptor HER3; HER3; ERBB3; EC 2.7.10.1 Dupilumab Interleukin 4 Receptor Subunit Alpha; CD124; Atopic Dermatitis; Nasal Polyposis; Sinusitis; Asthma; IL4R Eosinophilic Esophagitis; Food Allergy Durvalumab Programmed Cell Death 1 Ligand 1; PD L1; B7 Bladder Cancer; Metastatic Transitional (Urothelial) Tract Homolog 1; CD274 Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Non-Small Cell Lung Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); Adenocarcinoma Of The Gastroesophageal Junction; B-Cell Chronic Lymphocytic Leukemia; Diffuse Large B-Cell Lymphoma; Esophageal Cancer; Follicular Lymphoma; Gastric Cancer; Germ Cell Tumors; Glioblastoma Multiforme (GBM); Hepatocellular Carcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Lymphoma; Malignant Pleural Mesothelioma; Mantle Cell Lymphoma; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Renal Cell Carcinoma; Multiple Myeloma (Kahler Disease); Myelodysplastic Syndrome; Ovarian Cancer; Pancreatic Ductal Adenocarcinoma; Papillary Renal Cell Carcinoma; Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Small-Cell Lung Cancer; Ureter Cancer; Urethral Cancer; Urinary Tract Cancer; B-Cell Non-Hodgkin Lymphoma; Cervical Cancer; Endometrial Cancer; Melanoma; Metastatic Biliary Tract Cancer; Multiple Myeloma (Kahler Disease); Muscle Invasive Bladder Cancer (MIBC); Myelodysplastic Syndrome; T-Cell Lymphomas Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Mycosis Fungoides; Ovarian Cancer; Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF); Post- Polycythemia Vera Myelofibrosis (PPV-MF); Sezary Syndrome; Soft Tissue Sarcoma; Non-Small Cell Lung Cancer; Advanced Malignancy; Solid Tumor; Muscle Invasive Bladder Cancer (MIBC) Dusigitumab Insulin Like Growth Factor I; Mechano Growth Hormone Sensitive Breast Cancer; Metastatic Breast Cancer; Factor; Somatomedin C; IGF1; Insulin Like Advanced Malignancy; Solid Tumor; Metastatic Hepatocellular Growth Factor II; Somatomedin A; T3M II Carcinoma (HCC) Derived Growth Factor; IGF2 Duvortuxizumab B Lymphocyte Antigen CD19; B Lymphocyte Follicular Lymphoma; B-Cell Chronic Lymphocytic Leukemia; (JNJ-B4052781) Surface Antigen B4; Differentiation Antigen Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic CD19; T Cell Surface Antigen Lou 12; CD19; CD3 Leukemia); Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma Ecromeximab Ganglioside GD3 Metastatic Melanoma Eculizumab, Complement C5; C3 and PLP Like Alpha 2 Atypical Hemolytic Uremic Syndrome (Nondiarrhea- Erlizuab Macroglobulin Domain Containing Protein 4; Associated Hemolytic Uremic Syndrome); Paroxysmal C5 Nocturnal Hemoglobinuria; Myasthenia Gravis; Neuromyelitis Optica (Devic's Syndrome); Membranoproliferative Glomerulonephritis (Mesangiocapillary Glomerulonephritis); Acquired (Autoimmune) Hemolytic Anemia; Membraneproliferative Glomerulonephritis Type II (Dense Deposit Disease); Transplant Rejection; Vasculitis; Rheumatoid Arthritis; Dermatomyositis; Dry (Atrophic) Macular Degeneration; Allergic Asthma; Kidney Transplant Rejection; Typical Hemolytic Uremic Syndrome (Shiga-Toxin Associated Hemolytic Uremic Syndrome); Atypical HUS Efalizumab Integrin Alpha L; CDH Antigen Like Family Plaque Psoriasis (Psoriasis Vulgaris); Kidney Transplant Member A; Leukocyte Adhesion Glycoprotein Rejection; Rheumatoid Arthritis LFA 1Alpha Chain; CDIIa; ITGAL Efungumab Fungal Hsp90 Candida infection Eldelumab C—X—C Motif Chemokine 10; 10 kDa Interferon Crohn's Disease (Regional Enteritis); Ulcerative Colitis; Gamma Induced Protein; Small Inducible Rheumatoid Arthritis Cytokine B10; Gamma IP10; CXCL10 Elezanumab Repulsive Guidance Molecule-a; RGMA: Multiple Sclerosis Elgemtumab Receptor Tyrosine Protein Kinase ERBB 3; Esophageal Cancer; Squamous Cell Carcinoma; Gastric Proto Oncogene Like Protein c ErbB 3; Cancer; Metastatic Breast Cancer; Recurrent Head and Neck Tyrosine Kinase Type Cell Surface Receptor Cancer Squamous Cell Carcinoma HER3; HER3; ERBB3; EC 2.7.10.1 Elotuzumab LOIXC Monoclonal antibodies Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Multiple Myeloma (Kehler Disease) Emactuzumab Macrophage Colony Stimulating Factor 1 Pigmented Villonodular Synovitis; Bladder Cancer; Colorectal Receptor; CSF 1 Receptor; Proto Oncogene c Cancer; Endometrial Cancer; Fallopian Tube Cancer; Gastric Fms; CD115; CSFIR; EC 2.7.10.1 Cancer; Malignant Mesothelioma; Melanoma; Metastatic Breast Cancer; Metastatic Ovarian Cancer; Pancreatic Cancer; Soft Tissue Sarcoma; Tenosynovial Giant Cell Tumor Emapalumab IFNG hemophagocytic lymphohistiocytosis (N1-0501) Emibetuzumab Hepatocyte Growth Factor Receptor; Proto Adenocarcinoma Of The Gastroesophageal Junction; Gastric Oncogene c Met; Tyrosine Protein Kinase Met; Cancer; Metastatic Hepatocellular Carcinoma (HCC); HGF/SF Receptor; Scatter Factor Receptor; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; MET; EC 2.7.10.1 Bone Metastasis; Lymphoma; Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Metastatic Uveal Melanoma; Multiple Myeloma (Kehler Disease) Emicizumab Coagulation Factor IX; Christmas Factor; Hemophilia A Plasma Thromboplastin Component; F9; EC 3.4.21.22; Coagulation Factor X; Stuart Prower Factor; Stuart Factor; F10; EC 3.4.21.6 Enavatuzumab Tumor Necrosis Factor Receptor Superfamily Solid Tumor Member 12A; TWEAK Receptor; Fibroblast Growth Factor Inducible Immediate Early Response Protein 14; CD266; TNFRSF12A Enfortumab, Nectin 4; Ig Superfamily Receptor LNIR; Metastatic Transitional (Urothelial) Tract Cancer; Non-Small Enfortumab Poliovirus Receptor Related Protein 4; Nectin Cell Lung Cancer; Metastatic Breast Cancer; Solid Tumor vedotin Cell Adhesion Molecule 4; PVRL4; NECTIN4 Enlimomab, Intercellular Adhesion Molecule 1; Major Group Stroke Enlimomab pegol Rhinovirus Receptor; CD54; ICAM1 Enoblituzumab CD276 Antigen; B7 Homolog 3; 4Ig B7 H3; Bladder Cancer; Breast Cancer; Childhood Costimulatory Molecule; CD276 Rhabdomyosarcoma; Colon Cancer; Ewing Sarcoma; Head and Neck Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Malignant Mesothelioma; Metastatic Melanoma; Metastatic Transitional (Urothelial) Tract Cancer; Neuroblastoma; Non-Small Cell Lung Cancer; Osteosarcoma; Ovarian Cancer; Pancreatic Cancer; Primitive Neuroectodermal Tumor (PNET); Prostate Cancer; Renal Cell Carcinoma; Rhabdomyosarcoma; Soft Tissue Sarcoma; Squamous Non-Small Cell Lung Cancer; Thyroid Cancer; Wilms' Tumor (Nephroblastoma) Enokizumab Interleukin 9; Cytokine P40; T Cell Growth Allergic Asthma Factor P40; IL9 Enoticumab Delta Like Protein 4; Delta Like Ligand 4; Advanced Malignancy; Solid Tumor Drosophila Delta Homolog 4; DLL4 Ensituximab Mucin 5AC; Gastric Mucin; Lewis B Blood Metastatic Colorectal Cancer; Metastatic Pancreatic Cancer Group Antigen; Major Airway Glycoprotein; Tracheobronchial Mucin; MUC5AC Entolimod Toll Like Receptor 5; Toll/Interleukin 1 Adenoid Squamous Cell Carcinoma (Pseudoglandular Receptor Like Protein 3; TLR5 Squamous Cell Carcinoma); Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Liver Cancer; Uveal Melanoma; Radiation Toxicity (Radiation Sickness; Acute Radiation Syndrome); Colorectal Cancer Epratuzumab, B Cell Receptor CD22; B Lymphocyte Cell Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Yttrium (Y90) Adhesion Molecule; Sialic Acid Binding Ig Like Leukemia); Non-Hodgkin Lymphoma; Diffuse Large B-Cell epratuzumab Lectin 2; T Cell Surface Antigen Lau 14; CD22 Lymphoma; Follicular Lymphoma; Waldenstrom tetraxetan Macroglobulinemia; Sicca Syndrome (Sjogren); Systemic Lupus Erythematosus Eptacog beta Coagulation Factor VII; Proconvertin; Serum Congenital Hemophilia A; Congenital Hemophilia B; Hemophilia Prothrombin Conversion Accelerator; SPCA; Eptacog Alfa; F7; EC 3.4.21.21 Eptinezumab Calcitonin Gene Related Peptide; CGRP Migraine Erenumab Calcitonin Gene Related Peptide Type I Migraine; Stable Angina; Vasomotor Symptoms of Menopause Receptor; Calcitonin Receptor Like Receptor; (Hot Flashes) CALCRL Ertumaxomab Receptor Tyrosine Protein Kinase ERBB 2; Solid Tumor Metastatic Lymph Node Gene 19 Protein; Proto Oncogene Neu; Proto Oncogene C ErbB 2; Tyrosine Kinase Type Cell Surface Receptor HER2; pI85erbB2; HER2; CD340; ERBB2; EC 2.7.10.1; T Cell Surface Glycoprotein CD3 Epsilon Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; CD3E Etaracizumab Integrin Alpha V; Vitronectin Receptor Subunit Colorectal Cancer; Metastatic Hormone Refractory Alpha; CD51; ITGAV; Integrin Beta 3; Platelet (Castration Resistant; androgen-Independent) Prostate Membrane Glycoprotein IIIa; CD61; ITGB3 Cancer; Metastatic Melanoma; Psoriasis; Rheumatoid Arthritis Etrolizumab, Integrin Beta 7; Gut Homing Receptor Beta Hemophilia A; Hemophilia B; Crohn's Disease (Regional Etrolizuab Subunit; ITGB7; integrin α7 β7 Enteritis); Ulcerative Colitis; Inflammatory Bowel Disease Evinacumab Angiopoietin Related Protein 3; Angiopoietin 5; Homozygous Familial Hypercholesterolemia (HoFH); Angiopoietin Like Protein 3; ANG 5; ANGPTL3 Hyperlipidemia Evolocumab Proprotein Convertase Subtilisin/Kexin Type Familial Hypercholesterolemia (Type II Hyperlipoproteinemia); 9; Proprotein Convertase 9; Neural Apoptosis Hypercholesterolemia Atherosclerosis Heterozygous familial Regulated Convertase 1; Subtilisin/Kexin Like hypercholesterolemia (heFH); Homozygous Familial Protease PC9; PCSK9; EC 3.4.21. Hypercholesterolemia (HoFH); Hypercholesterolemia Exbivirumab Hepatitis B Virus Surface Antigen; HBsAg Hepatitis B Exenatide Glucagon Like Peptide 1 Receptor; GLPIR Obesity; Type 2 Diabetes Faralimomab Interferon Alpha/Beta Receptor 1; Cytokine Rheumatoid Arthritis; Systemic Lupus Erythematosus Receptor Class II Member 1; Cytokine Receptor Family 2 Member 1; Type 1 Interferon Receptor 1; IFNAR1 Farletuzumab Folate Receptor Alpha; Adult Folate Binding Lung Adenocarcinoma; Ovarian Cancer; Pituitary Tumor Protein; Folate Receptor 1; KB Cells FBP; Ovarian Tumor Associated Antigen MDv18; FOLR1 Fasinumab Beta Nerve Growth Factor; Beta NGF; NGF Low Back Pain; Osteoarthritis Pain; Chronic Pancreatitis Pain; Sciatic Pain; Vertebral Fracture Pain Ferritizumab Ferritin Non-Small Cell Lung Cancer; Pancreatic Cancer Fezakinumab Interleukin 22; Cytokine Zcyto18; IL 10 Related Psoriasis; Rheumatoid Arthritis T Cell Derived Inducible Factor; IL22 FG-3019, Connective Tissue Growth Factor; CCN Family Duchenne Muscular Dystrophy; Pancreatic Ductal Pamrevlumab Member 2; Hypertrophic Chondrocyte Adenocarcinoma; Idiopathic Pulmonary Fibrosis; Liver Fibrosis; Specific Protein 24; Insulin Like Growth Focal Segmental Glomerulosclerosis (FSGS); Microalbuminuria; Factor Binding Protein 8; IGFBP8; CTGF Proteinuria; Systemic Sclerosis (Scleroderma); Diabetic Nephropathy; Type 1 Diabetes (Juvenile Diabetes); Type 2 Diabetes Fibatuzumab EPHA3; ephrin receptor A3 Glioblastoma Multiforme (GBM); Solid Tumor; Myelofibrosis; Myelodysplastic Syndrome; Multiple Myeloma (Kehler Disease); Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); Chronic Lymphocytic Leukemia (CLL); Chronic Myelocytic Leukemia (CML; Chronic Myeloid Leukemia); Myeloproliferative Disorders Ficlatuzumab Hepatocyte Growth Factor Receptor; Proto Nasopharyngeal Cancer; Recurrent Head and Neck Cancer Oncogene c Met; Tyrosine Protein Kinase Met; Squamous Cell Carcinoma; Refractory Acute Myeloid Leukemia; HGF/SF Receptor; Scatter Factor Receptor; Relapsed Acute Myeloid Leukemia; Esophageal Cancer; Gastric MET; EC 2.7.10.1 Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Hypopharyngeal Cancer; Laryngeal Cancer; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Metastatic Pancreatic Cancer; Multiple Myeloma (Kehler Disease); Non-Hodgkin Lymphoma; Oral Cavity (Mouth) Cancer; Oropharyngeal Cancer; Non-Small Cell Lung Cancer Figitumumab Insulin Like Growth Factor 1 Receptor; CD221; Adenocarcinoma; Breast Cancer; Colon Cancer; Multiple IGFIR; EC 2.7.10.1 Myeloma (Kehler Disease); Rectal Cancer; Breast Cancer; Ewing Sarcoma; Gastrointestinal Tract Cancer; Hormone- Sensitive Prostate Cancer; Non-Small Cell Lung Cancer; Small- Cell Lung Cancer; Urinary Tract Cancer Firivumab Hemagglutinin Unspecified Influenza Virus Infections Flanvotumab 5,6 Dihydroxyindole 2 Carboxylic Acid Melanoma Oxidase; Glycoprotein 75; Melanoma Antigen gp75; Tyrosinase Related Protein 1; Catalase B; TYRP1; EC 1.14.18. Fletikumab Interleukin 20; Cytokine Zcyto10; IL20 Psoriasis; Rheumatoid Arthritis Fontolizumab Interferon Gamma; Immune Interferon; IFNG Colitis; Crohn's Disease (Regional Enteritis); Rheumatoid Arthritis Foralumab T Cell Surface Glycoprotein CD3 Epsilon Crohn's Disease (Regional Enteritis); Autoimmune Disorders; Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Kidney Transplant Rejection; Inflammatory Bowel Disease; Chain; CD3E Non-Alcoholic Steatohepatitis; Type 1 Diabetes (Juvenile Diabetes) Foravirumab Rabies Virus Glycoprotein Rabies Fremanezumab Calcitonin Gene Related Peptide; CGRP Cluster Headache Syndrome; Migraine; Vasomotor Symptoms of Menopause (Hot Flashes) Fresolimumab Transforming Growth Factor Beta 1; TGFB1; Non-Small Cell Lung Cancer; Osteogenesis Imperfecta; Glioma; Transforming Growth Factor Beta 2; BSC1Cell Melanoma; Renal Cell Carcinoma; Solid Tumor; Idiopathic Growth Inhibitor; Cetermin; Glioblastoma Pulmonary Fibrosis; Focal Segmental Glomerulosclerosis Derived T Cell Suppressor Factor; Polyergin; (FSGS) TGFB2; Transforming Growth Factor Beta 3; TGFB3 Frunevetmab Mus musculus nerve growth factor; Felis Control of Osteoarthritis Pain in Cats catus-Rattus norvegicus monoclonal NV-02 heavy chain; disulfide with Felis catus-Rattus norvegicus monoclonal NV-02 light chain; dimer Fulranumab Beta Nerve Growth Factor; Beta NGF; NGF Pain; Chronic Visceral Pain; Diabetic Neuropathic Pain; Low Back Pain; Postherpetic Neuralgia; Interstitial Cystitis (Painful Bladder Syndrome); Cancer Pain; Osteoarthritis Pain Futuximab Epidermal Growth Factor Receptor; Proto Glioblastoma Multiforme (GBM); Metastatic Colorectal Cancer; Oncogene c ErbB1; Receptor Tyrosine Protein Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Kinase erbB1; HER1; ERBB1; EGFR; EC 2.7.10.1 Squamous Non-Small Cell Lung Cancer; Esophageal Cancer; Solid Tumor Galcanezumab Calcitonin Gene Related Peptide; CGRP Cluster Headache Syndrome; Migraine; Osteoarthritis Pain Galiximab, T Lymphocyte Activation Antigen CD80; Autoimmune Disorders; Inflammation; Psoriasis; Rheumatoid Goilixiab Activation B7-1 Antigen; CTLA 4 Counter Arthritis; Follicular Lymphoma; B-cell Lymphoma Receptor B7.1; CD80 Ganitumab Insulin Like Growth Factor 1 Receptor; CD221; Breast Cancer; Neuroendocrine Tumors; Ovarian Cancer; IGFIR; EC 2.7.10.1 Ewing Sarcoma; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Non-Hodgkin Lymphoma; Small-Cell Lung Cancer; Soft Tissue Sarcoma; Squamous Non-Small Cell Lung Cancer; Metastatic Adenocarcinoma of The Pancreas; Metastatic Pancreatic Cancer Gantenerumab Amyloid Beta Peptide; A beta P; Abeta; Beta Alzheimer's Disease Amyloid Gatipotuzumab Homo sapiens MUC1; mucin 1; polymorphic epithelial mucin; PEM; episialin; CD227 tumor antigen TA-MUC1 conformational epitope O- glycosylated on the threonine of the immunodominant PDTRP motif of the tandem repeats Gavilimomab Basigin; Collagenase Stimulatory Factor; Graft Versus Host Disease (GVHD) Extracellular Matrix Metalloproteinase Inducer; Leukocyte Activation Antigen MG; OK Blood Group Antigen; Tumor Cell Derived Collagenase Stimulatory Factor; CD147; BSG Gedivumab Influenza A virus hemagglutinin HA Influenza disease; Gemetuzumab, Myeloid Cell Surface Antigen CD33; Sialic Acid Acute Myelocytic Leukemia (AML) Gemtuzumab Binding Ig Like Lectin 3; gp67; CD33 ozogamicin, Gemtuzumab Gerilimzumab Interleukin 6; B Cell Stimulatory Factor 2; Autoimmune Disorders; Inflammation; Rheumatoid Arthritis BSF2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta 2; IFNB2; IL6 Gevokizumab Interleukin 1 Beta; IL 1 Beta; Catabolin; IL1B Acute Coronary Syndrome; Behcet Disease; Giant Cell Arteritis; Schnitzler Syndrome; Dermatomyositis; Polymyositis; Uveitis; Behcet Disease; Acne Vulgaris; Skin Inflammation; Autoimmune Disorders; Rheumatoid Arthritis; Diabetic Nephropathy; Type 2 Diabetes; Type 1 Diabetes (Juvenile Diabetes); Gouty Arthritis (Gout); Osteoarthritis; Systemic Idiopathic Juvenile Arthritis; Multiple Myeloma (Kehler Disease); Anterior Uveitis; Intermediate Uveitis; Posterior Uveitis; Uveitis; Scleritis Gilvetmab Canis familiaris PDCD1 Antineoplastic; Immunotherapy (Veterinary) Gimsilumab Granulocyte Macrophage Colony Stimulating Rheumatoid Arthritis Factor; GMCSF; Colony Stimulating Factor; CSF; Molgramostin; Sargramostim; CSF2 Girentuximab, Carbonic Anhydrase 9; Carbonate Renal Cell Carcinoma Iodine (1241) Dehydratase IX; pMW1; Membrane Antigen MN; girentuximab P54/58N; Renal Cell Carcinoma Associated Antigen G250; CA9; EC 4.2.1.1; CA-IX Glembatumumab Transmembrane Glycoprotein NMB; Lung Cancer; Osteosarcoma; Metastatic Uveal Melanoma; vedotin Transmembrane Glycoprotein HGFIN; GPNMB Metastatic Breast Cancer; Metastatic Melanoma; Squamous Non-Small Cell Lung Cancer Glunomab Glutamate Receptor Ionotropic NMDA 1; Multiple Sclerosis Glutamate [NMDA] Receptor Subunit Zeta 1; N Methyl D Aspartate Receptor Subunit NR1; GRIN1 Golimumab Tumor Necrosis Factor; Cachectin; TNF Alpha; Ulcerative Colitis; Ankylosing Spondylitis (Bekhterev's Tumor Necrosis Factor Ligand Superfamily Disease); Axial Spondyloarthritis; Psoriatic Arthritis; Member 2; TNF a; TNF Rheumatoid Arthritis; Ankylosing Spondylitis (Bekhterev's Disease); Psoriatic Arthritis; Systemic Idiopathic Juvenile Arthritis; Type 1 Diabetes (Juvenile Diabetes); Sarcoidosis; Systemic Idiopathic Juvenile Arthritis; Anterior Uveitis; Posterior Uveitis; Asthma Guselkumab Interleukin 23 Subunit Alpha; Interleukin 23 Plaque Psoriasis (Psoriasis Vulgaris); Psoriatic Arthritis; Subunit p19; IL23A Rheumatoid Arthritis HuMab IDF8 IL8 Inflammatory bowel disease and asthma HuMab LC5002- Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic Pulmonary Fibrosis; 002 Pulmonary Fibrosis; Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis; Systemic Sclerosis (Scleroderma); Allergies HuMab LC5002- Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic Pulmonary Fibrosis; 003 Pulmonary Fibrosis; Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis; Systemic Sclerosis (Scleroderma); Allergies HuMab LC5002- Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic Pulmonary Fibrosis; 005 Pulmonary Fibrosis; Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis; Systemic Sclerosis (Scleroderma); Allergies HuMab LC5002- Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic Pulmonary Fibrosis; 007 Pulmonary Fibrosis; Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis; Systemic Sclerosis (Scleroderma); Allergies HuMab LC5002- Interleukin 13 Asthma; Atopic Dermatitis; Idiopathic Pulmonary Fibrosis; 018 Pulmonary Fibrosis; Seasonal Allergic Rhinitis; Lymphedema; Ulcerative Colitis; Systemic Sclerosis (Scleroderma); Allergies HuMab-708 CD20 Diseases associated with CD20 (including tumor-related diseases) and immune diseases (including autoimmune diseases) huMAb-anti- merozoite surface protein 10; MSP-10 Malaria; Plasmodium associate Diseases MSP10.1 huMAb-anti- merozoite surface protein 10; MSP-10 Malaria; Plasmodium associate Diseases MSP10.2 HuMab-L612 Ganglioside GM3 metastatic melanoma Ibalizumab T Cell Surface Glycoprotein CD4; T Cell Human Immunodeficiency Virus (HIV) Infections (AIDS) Surface Antigen T4/Leu 3; CD4 Ibritumomab, B Lymphocyte Antigen CD20; B Lymphocyte Acute Lymphocytic Leukemia (ALL); Acute Myelocytic Leukemia Ibritumomab Surface Antigen B1; Bp35; Leukocyte Surface (AML); Chronic Lymphocytic Leukemia (CLL); Chronic tiuxetan Antigen Leu 16; Membrane Spanning 4 Myelocytic Leukemia (CML); Multiple Myeloma (Kahler Disease); Domains Subfamily A Member 1; CD20; MS4A1 Myeloproliferative Disorders; Colorectal Cancer; Gastric Cancer; Melanoma; Prostate Cancer; Myelodysplastic Syndrome; Myelofibrosis; Glioblastoma Multiforme (GBM); Solid Tumor; non-Hodgkin's Lymphoma Icrucumab Vascular Endothelial Growth Factor Receptor Metastatic Breast Cancer; Metastatic Colorectal Cancer; 1; Fms Like Tyrosine Kinase 1; Tyrosine Protein Transitional Cell Carcinoma (Urothelial Cell Carcinoma) Kinase Receptor FLT; Tyrosine Protein Kinase FRT; Vascular Permeability Factor Receptor; VEGFR1; FLT1; EC 2.7.10.1 Idarucizumab Dabigatran; Pradaxa ® Bleeding and Clotting Disorders Ifabotuzumab CD22 Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); Chronic Lymphocytic Leukemia (CLL); Chronic Myelocytic Leukemia (CML; Chronic Myeloid Leukemia); Multiple Myeloma (Kahler Disease); Myeloproliferative Disorders; Colorectal Cancer; Gastric Cancer; Melanoma; Prostate Cancer; Myelodysplastic Syndrome; Myelofibrosis; Glioblastoma Multiforme (GBM); Solid Tumor IGF-IR HUMAB-1A Soluble extracellular domain of IGF-IR. Tumor; Cancer IGF-IR HUMAB- Soluble extracellular domain of IGF-IR. Tumor; Cancer 23 IGF-IR HUMAB-8 Soluble extracellular domain of IGF-IR. Tumor; Cancer ImAb1 IDH1R132H Glioma Imalumab Macrophage Migration Inhibitory Factor; Metastatic Colorectal Cancer; Solid Tumor; Septic Shock; Glycosylation Inhibiting Factor; L Dopachrome Multiple Sclerosis; Colitis; Glomerulonephritis; Lupus Nephritis; Isomerase; L Dopachrome Tautomerase; Diabetes; Arthritis; Malignant Ascites Phenylpyruyate Tautomerase; MIF; EC 5.3.2.1; EC 5.3.3.12 Imgatuzumab Epidermal Growth Factor Receptor; Proto Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Oncogene c ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Non-Small Cell Lung Cancer; Solid Tumor Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Inclacumab P Selectin; CD62 Antigen Like Family Member Peripheral Arterial Disease (PAD)/ Peripheral Vascular P; Granule Membrane Protein 140: Leukocyte Disease (PVD); Acute Coronary Syndrome; Myocardial Endothelial Cell Adhesion Molecule 3; LECAM3; Infarction; Percutaneous Coronary Intervention Platelet Activation Dependent Granule External Membrane Protein; CD62P; SELP Inhibitor Indatuximab, Syndecan I; CD138; SDC1 Lung Cancer; Prostate Cancer; Head and Neck Cancer; Indatuximab Pancreatic Cancer; Breast Cancer; Bladder Cancer; ravtansine Refractory Multiple Myeloma; Relapsed Multiple Myeloma Indusatumab, Heat Stable Enterotoxin Receptor; Guanylyl Metastatic Colorectal Cancer; Adenocarcinoma Of The Indusatumab Cyclase C; or Intestinal Guanylate Cyclase; Gastroesophageal Junction; Gastric Cancer; Adenocarcinoma vedotin GUCY2C; EC 4.6.1.2 Of The Gastroesophageal Junction; Gastric Cancer; Metastatic Adenocarcinoma of The Pancreas Inebilizumab Central Nervous System Progressive Relapsing Multiple Sclerosis (PRMS); Relapsing Remitting Multiple Sclerosis (RRMS); Secondary Progressive Multiple Sclerosis (SPMS); Neuromyelitis Optica (Devic's Syndrome); Follicular Lymphoma; Mantle Cell Lymphoma; Non- Hodgkin Lymphoma; Follicular Lymphoma; Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Multiple Myeloma (Kahler Disease); Systemic Sclerosis (Scleroderma); Diffuse Large B- Cell Lymphoma; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL) Infliximab Tumor Necrosis Factor; Cachectin; TNF Alpha; Crohn's Disease (Regional Enteritis); Ulcerative Colitis Plaque Tumor Necrosis Factor Ligand Superfamily Psoriasis (Psoriasis Vulgaris); Psoriasis; Rheumatoid Arthritis Member 2; TNF a; TNF; TNFa Ankylosing Spondylitis (Bekhterev's Disease); Psoriatic Arthritis Behcet Disease Crohn's Disease (Regional Enteritis); Ulcerative Colitis Mucocutaneous Lymph Node Syndrome (Kawasaki Disease); Plaque Psoriasis (Psoriasis Vulgaris); Psoriasis; Rheumatoid Arthritis Giant Cell Arteritis Juvenile Rheumatoid Arthritis; Sarcoidosis Cancer Anorexia-Cachexia Syndrome Hepatitis C; Autoimmune Disease Inolimomab Interleukin 2 Receptor Subunit Alpha; TAC Graft Versus Host Disease (GVHD) Antigen; p55; CD25; IL2RA Insulin peglispro Insulin Receptor; IR; CD220; INSR; EC 2.7.10.1 Type 1 Diabetes (Juvenile Diabetes); Type 2 Diabetes Interferon beta- Interferon Alpha/Beta Receptor 1; Cytokine Alopecia; Demyelinating Diseases; Multiple Sclerosis; Relapsing 1b Receptor Class II Member 1; Cytokine Remitting Multiple Sclerosis (RRMS); Secondary Progressive Receptor Family 2 Member 1; Type I Interferon Multiple Sclerosis (SPMS) Receptor 1; IFNAR1; Interferon Alpha/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2 Intetumumab Integrin Alpha V; Vitronectin Receptor Subunit Angiosarcoma; Hormone Refractory (Castration Resistant; Alpha; CD51; ITGAV; Integrin Beta 1; Fibronectin androgen-Independent) Prostate Cancer; Metastatic Receptor Subunit Beta; Glycoprotein lia; VLA 4 Melanoma; Melanoma Subunit Beta; CD29; ITGB1; Integrin Beta 3; Platelet Membrane Glycoprotein IIIa; CD61; ITGB3; Integrin Beta 5; ITGB5; Integrin Beta 6; ITGB6 Ipilimumab Cytotoxic T Lymphocyte Protein 4; Cytotoxic T Metastatic Melanoma; Head and Neck Cancer Squamous Cell Lymphocyte Associated Antigen 4; CD152; Carcinoma; Metastatic Renal Cell Carcinoma; Non-Small Cell CTLA4 Lung Cancer Adenocarcinoma Of The Gastroesophageal Junction; Adrenal Gland Cancer; Gastric Cancer; Metastatic Liver Cancer; Metastatic Lung Cancer; Ovarian Cancer; Skin Cancer Chronic Myelocytic Leukemia (CML; Chronic Myeloid Leukemia); Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Non-Hodgkin Lymphoma; Refractory Multiple Myeloma; Relapsed Multiple Myeloma Adenocarcinoma; Breast Cancer; Metastatic Adenocarcinoma of The Pancreas; Transitional Cell Cancer (Urothelial Cell Cancer); Metastatic Hormone Refractory (Castration Resistant; androgen-Independent); Prostate Cancer Iratumumab Tumor Necrosis Factor Receptor Superfamily Anaplastic Large Cell Lymphoma (ALCL); Hodgkin Lymphoma Member 8; CD30L Receptor; Ki 1 Antigen; (B-Cell Hodgkin Lymphoma) Lymphocyte Activation Antigen CD30; CD30; TNFRSF8 Isatuximab ADP Ribosyl Cyclase/Cyclic ADP Ribose Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Hydrolase 1; Cyclic ADP Ribose Hydrolase 1; Multiple Myeloma (Kahler Disease); Acute Lymphocytic T10; 2′ Phospho ADP Ribosyl Cyclase/2′ Leukemia (ALL; Acute Lymphoblastic Leukemia); Acute Phospho Cyclic ADP Ribose Transferase; ADP Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); B- Ribosyl Cyclase 1; CD38; EC 3.2.2.6; EC Cell Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia 2.4.99.20 (CLL) Itolizumab T Cell Differentiation Antigen CD6; T12; TP120; Plaque Psoriasis (Psoriasis Vulgaris); Arthritis; Relapsing CD6 Remitting Multiple Sclerosis (RRMS); Rheumatoid Arthritis; Vitiligo; Psoriatic Arthritis Ixekizumab Interleukin 17A; Cytotoxic T Lymphocyte Ankylosing Spondylitis (Bekhterev's Disease); Rheumatoid Associated Antigen 8; CTLA8; IL17A Arthritis; Plaque Psoriasis (Psoriasis Vulgaris); Psoriatic Arthritis; Axial Spondyloarthritis Labetuzumab, Carcinoembryonic Antigen Related Cell Ovarian Cancer; Small-Cell Lung Cancer; Metastatic Colorectal Labetuzumab Adhesion Molecule 5; Carcinoembryonic Cancer; Colorectal Cancer govitecan Antigen; CEA; Meconium Antigen 100; CD66e; CEACAM5 Lacnotuzumab Macrophage Colony Stimulating Factor 1 Pigmented Villonodular Synovitis; Tenosynovial Giant Cell Receptor; CSF 1 Receptor; Proto Oncogene c Tumor; Glioblastoma Multiforme (GBM); Head and Neck Cancer Fms; CD115; CSF1R; EC 2.7.10.1 Squamous Cell Carcinoma; Melanoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Renal Cell Carcinoma; Colorectal Cancer; Rheumatoid Arthritis Lampalizumab Complement Factor D; C3 Convertase Dry (Atrophic) Macular Degeneration Activator; Adipsin; Properdin Factor D; CFD; EC 3.4.21.46 Lanadelumab Kallikrein; EC 3.4.21. Diabetic Macular Edema; Hereditary Angioedema (HAE) (C1 Esterase Inhibitor [C1-INH] Deficiency) Landogrozumab Growth/Differentiation Factor 8; Myostatin; Cancer Anorexia-Cachexia Syndrome; Muscle Atrophy GDF8; MSTN Laprituximab, EGFR; epidermal growth factor receptor Laprituximab emtansine Larcaviximab Ebolavirus glycoprotein Ebola virus infections Lebrikizumab Interleukin 13; IL13 Idiopathic Pulmonary Fibrosis; Atopic Dermatitis; Chronic Obstructive Pulmonary Disease (COPD); Idiopathic Pulmonary Fibrosis; Asthma Lendalizumab Complement 5; Anaphylatoxine; C5a; C5 Pr678-751];. Lenercept Tumor Necrosis Factor Receptor Superfamily Septic Shock; Multiple Sclerosis; Rheumatoid Arthritis; Sepsis; Member 1A; Tumor Necrosis Factor Receptor 1; Tumor Necrosis Factor Receptor Type I; p55; p60; CD120a; TNFRSF1A Lenzilumab Granulocyte Macrophage Colony Stimulating Leukemias Multiple Sclerosis Psoriasis Bone Cancer; Juvenile Factor; GMCSF; Colony Stimulating Factor; Myelomonocytic Leukemia (JMML) Chronic Obstructive CSF; Molgramostin; Sargramostim; CSF2 Pulmonary Disease (COPD) Rheumatoid Arthritis Asthma Lerdelimumab Transforming Growth Factor Beta 2; BSC1 Cell Glaucoma Drainage Surgery Growth Inhibitor; Cetermin; Glioblastoma Derived T Cell Suppressor Factor; Polyergin; TGFB2 Lesofavumab Influenza B virus hemagglutinin HA Infectious Disease Letolizumab CD40 Ligand; T Cell Antigen Gp39; TNF Related Idiopathic Thrombocytopenic Purpura (Immune Activation Protein; Tumor Necrosis Factor Thrombocytopenic Purpura) Ligand Superfamily Member 5; CD154; CD40LG Lexatumumab Tumor Necrosis Factor Receptor Superfamily Solid Tumor Member 10B; Death Receptor 5; TNF Related Apoptosis Inducing Ligand Receptor 2; TRAIL Receptor 2; DR5; CD262; TNFRSF10B Libivirumab Hepatitis B Virus Surface Antigen; HBsAg Hepatitis B Lifastuzumab, Sodium Dependent Phosphate Transport Non-Small Cell Lung Cancer; Ovarian Cancer Lifastuzumab Protein 2B; Sodium Phosphate Transport vedotin Protein 2B; NaPi3b; Sodium/Phosphate Cotransporter 2B; NaPi 2b; Solute Carrier Family 34 Member 2; SLC34A2; phosphate- sodium co-transporter Ligelizumab Immunoglobulin E; IgE Allergic Asthma; Chronic Urticaria; Hives; Atopic Dermatitis; Bullous Pemphigoid Lilotomab, Leukocyte Antigen CD37; Tetraspanin 26; Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Mantle Betalutin, CD37 Cell Lymphoma; Marginal Zone B-cell Lymphoma Lutetium (I77Lu) Lilotomab satetraxetan Lintuzumab, Myeloid Cell Surface Antigen CD33; Sialic Acid Refractory Acute Myeloid Leukemia; Acute Myelocytic Actimab-A Binding Ig Like Lectin 3; gp67; CD33 Leukemia (AML; Acute Myeloblastic Leukemia); Relapsed Acute Myeloid Leukemia Lirilumab Killer Cell Immunoglobulin Like Receptor 2DL1; Chronic Lymphocytic Leukemia (CLL); Gastrointestinal Tract CD158 Antigen Like Family Member A; MHC Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Class I NK Cell Receptor; CD158a; KIR2DL1 Hepatocellular Carcinoma; Melanoma; Myelodysplastic Antagonist; Killer Cell Immunoglobulin Like Syndrome; Non-Small Cell Lung Cancer; Refractory Acute Receptor 2DL2; CD158 Antigen Like Family Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia Member B1; MHC Class I NK Cell Receptor; (CLL); Relapsed Acute Myeloid Leukemia; Relapsed Chronic Natural Killer Associated Transcript 6; Lymphocytic Leukemia (CLL); Chronic Myelocytic Leukemia CD158b1; KIR2DL2 Antagonist; Killer Cell (CML; Chronic Myeloid Leukemia); Hodgkin Lymphoma (B-Cell Immunoglobulin Like Receptor 2DL3; MHC Hodgkin Lymphoma); Metastatic Hormone Refractory Class I NK Cell Receptor; Killer Inhibitory (Castration Resistant; androgen-Independent) Prostate Receptor cl 2-3; Natural Killer Associated Cancer; Non-Hodgkin Lymphoma; Refractory Multiple Myeloma; Transcript 2; CD158b2; KIR2DL3 Antagonist Relapsed Multiple Myeloma Lodelcizumab Proprotein Convertase Subtilisin/Kexin Type Bacterial Sepsis; Inflammation; Hypercholesterolemia 9; Proprotein Convertase 9; Neural Apoptosis Regulated Convertase 1; Subtilisin/Kexin Like Protease PC9; PCSK9; EC 3.4.21. Lokivetmab Interleukin 31 canine atopic dermatitis Lorvotuzumab, Neural Cell Adhesion Molecule 1; Antigen Ovarian Cancer; Non-Small Cell Lung Cancer; Skin Cancer; Lorvotuzumab Recognized By Monoclonal Antibody 5.1H11; Neuroendocrine Tumors; Small-Cell Lung Cancer; mertansine CD56; NCAMI Neuroendocrine Carcinoma; Refractory Multiple Myeloma; Relapsed Multiple Myeloma Losatuxizumab Epidermal Growth Factor Receptor; Proto Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Oncogene c ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Non-Small Cell Lung Cancer; Solid Tumor Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Lpathomab Lysophosphatidic Acid; LPA Neuropathic Pain; Traumatic Brain Injury; Chronic Pain; Postherpetic Neuralgia; Spinal Cord Injury Kidney Fibrosis Diabetic Neuropathy Pulmonary Fibrosis Chemotherapy Induced Peripheral Neuropathy Wet (Neovascular/Exudative) Macular Degeneration Lucatumumab CD40 Ligand; T Cell Antigen Gp39; TNF Related Follicular Lymphoma; Hematological Tumor; Multiple Myeloma Activation Protein; Tumor Necrosis Factor (Kehler Disease); Non-Hodgkin Lymphoma; Chronic Ligand Superfamily Member 5; CD154; Lymphocytic Leukemia (CLL); Hodgkin Lymphoma (B-Cell CD40LG; Tumor Necrosis Factor Receptor Hodgkin Lymphoma) Superfamily Member 5; B Cell Surface Antigen CD40; Bp50; CDw40; CD40L Receptor; TNFRSF5; CD40 Lulizumab T Cell Specific Surface Glycoprotein CD28; Sicca Syndrome (Sjogren); Systemic Lupus Erythematosus TP44; CD28 Lulizumab pegol T Cell Specific Surface Glycoprotein CD28; Sicca Syndrome (Sjogren); Systemic Lupus Erythematosus TP44; CD28 Lumiliximab Low Affinity Immunoglobulin Epsilon Fc Atopic Dermatitis Chronic Lymphocytic Leukemia (CLL) Allergic Receptor; BLAST 2; C Type Lectin Domain Asthma Allergic Rhinitis Family 4 Member J; Fc Epsilon RII; Immunoglobulin E Binding Factor; Lymphocyte IgE Receptor; CD23; FCER2 Lumretuzumab Receptor Tyrosine Protein Kinase ERBB 3; Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Proto Imogene Like Protein c ErbB 3; Squamous Non-Small Cell Lung Cancer;; Colorectal Cancer; Tyrosine Kinase Type Cell Surface Receptor Head and Neck Cancer Squamous Cell Carcinoma; Non-Small HER3; HER3; ERBB3; EC 2.7.10.1 Cell Lung Cancer Lupartumab HUMAN GPI-ANCHORED CELL SURFACE- Neoplastics ASSOCIATED PROTEIN C4.4A Lutikizumab IL1A; interleukin 1 alpha and interleukin 1 beta; Osteoarthritis (OA) IL1B Mapatumumab Tumor Necrosis Factor Receptor Superfamily Hepatocellular Carcinoma; Cervical Cancer; Non-Hodgkin Member 10A; Death Receptor 4; TNF Related Lymphoma; Non-Small Cell Lung Cancer; Refractory Multiple Apoptosis Inducing Ligand Receptor 1; TRAIL Myeloma; Relapsed Multiple Myeloma Receptor 1; DR4; CD261; TNFRSF10A Margetuximab Receptor Tyrosine Protein Kinase ERBB 2; Metastatic Breast Cancer; Breast Cancer; Gastric Cancer; Metastatic Lymph Node Gene 19 Protein; Proto Gastroesophageal (GE) Junction Carcinomas; Colorectal Oncogene Neu; Proto Oncogene C ErbB 2; Cancer; Esophageal Cancer; Head and Neck Cancer; Tyrosine Kinase Type Cell Surface Receptor Hepatocellular Carcinoma; Cervical Cancer; Non-Hodgkin HER2; p185erbB2; HER2; CD340; ERBB2; EC Lymphoma; Non-Small Cell Lung Cancer; Refractory Multiple 2.7.10.1 Myeloma; Relapsed Multiple Myeloma; Solid Tumor Marzeptacog Coagulation Factor VII; Proconvertin; Serum Hemophilia A; Hemophilia B alfa Prothrombin Conversion Accelerator; SPCA; Eptacog Alfa; F7; EC 3.4.21.21 Matuzumab Epidermal Growth Factor Receptor; Proto Lung Cancer; Ovarian Cancer; Non-Small Cell Lung Cancer; Oncogene c ErbB 1; Receptor Tyrosine Protein Non-Small Cell Lung Cancer; Esophageal Cancer; Gastric Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Cancer; Metastatic Colorectal Cancer Mavrilimumab Granulocyte Colony Stimulating Factor Rheumatoid Arthritis Receptor; CD114; GCSFR; CSF3R MDX-1303, Anthrax Protective Antigen; pa Anthrax Valortim Mepolizumab Interleukin 5; Eosinophil Differentiation Hypereosinophilic Syndrome; Nasal Polyps; Atopic Dermatitis; Factor; B Cell Differentiation Factor 1; T Cell Asthma; Chronic Obstructive Pulmonary Disease (COPD); Replacing Factor; IL5 Churg-Strauss Syndrome; Hypereosinophilic Syndrome Metelimumab Transforming Growth Factor Beta 1; TGFB1 Systemic Sclerosis (Scleroderma) Milatuzumab HLA Class II Histocompatibility Antigen B-Cell Non-Hodgkin Lymphoma; Systemic Lupus Gamma Chain; HLA DR Antigens Associated Erythematosus; Graft Versus Host Disease (GVHD); Chronic Invariant Chain; 1a Antigen Associated Lymphocytic Leukemia (CLL); Refractory Multiple Myeloma; Invariant Chain; p33; CD74 Relapsed Multiple Myeloma Mirvetuximab Folate Receptor Alpha; Adult Folate Binding Metastatic Breast Cancer; Fallopian Tube Cancer; Epithelial soravtansine Protein; Folate Receptor 1; KB Cells FBP; Ovarian Cancer; Peritoneal Cancer; Renal Cell Carcinoma; Ovarian Tumor Associated Antigen M0v18; Non-Small Cell Lung Cancer; Endometrial Cancer; FOLRI” Adenocarcinoma Modotuximab Epidermal Growth Factor Receptor; Proto Esophageal Cancer; Solid Tumor; Glioblastoma Multiforme Oncogene c ErbB 1; Receptor Tyrosine Protein (GBM); Metastatic Colorectal Cancer; Recurrent Head and Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Neck Cancer Squamous Cell Carcinoma; Squamous Non-Small Cell Lung Cancer Mogamulizumab C-C Chemokine Receptor Type 4; K5-5; CD194; Allergic Rhinitis; Asthma; T-Cell Leukemia; T-Cell Lymphomas; CCR4 Breast Cancer; Gastric Cancer; Non-Small Cell Lung Cancer; Solid Tumor; Cutaneous T-Cell Lymphoma; Peripheral T-Cell Lymphomas (PTCL); T-Cell Leukemia; T-Cell Lymphomas Monalizumab NKG2 A/NKG2 B Type II Integral Membrane Cervical Cancer; Chronic Lymphocytic Leukemia (CLL); Protein; NK Cell Receptor A; NKG2 A/B Endometrial Cancer; Fallopian Tube Cancer; Ovarian Cancer; Activating NK Receptor; CD159a; KLRC1 Peritoneal Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL); Rheumatoid Arthritis; Oral Cavity (Mouth) Cancer; Squamous Cell Carcinoma Motavizumab Respiratory Syncytial Virus Fusion Protein; Respiratory Syncytial Virus (RSV) Infections RSV F Protein Moxetumomab, B Cell Receptor CD22; B Lymphocyte Cell Hairy Cell Leukemia; Acute Lymphocytic Leukemia (ALL; Acute Moxetumomab Adhesion Molecule; Sialic Acid Binding Ig Like Lymphoblastic Leukemia); Follicular Lymphoma; Relapsed pasudotox Lectin 2; T Cell Surface Antigen Lau 14; CD22 Chronic Lymphocytic Leukemia (CLL); Refractory Chronic Lymphocytic Leukemia (CLL); Diffuse Large B-Cell Lymphoma; B-Cell Non-Hodgkin Lymphoma; Mantle Cell Lymphoma Muromonab-CD3 T Cell Surface Glycoprotein CD3 Epsilon Heart Transplant Rejection; Kidney Transplant Rejection; Liver Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Transplant Rejection Chain; CD3E Namilumab Granulocyte Macrophage Colony Stimulating Rheumatoid Arthritis; Plaque Psoriasis (Psoriasis Vulgaris) Factor; GMCSF; Colony Stimulating Factor; CSF; Molgramostin; Sargramostim; CSF2 Naptumomab Trophoblast Glycoprotein; M6P1; 5T4 Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Pancreatic estafenatox Oncofetal Antigen; 5T4 Oncofetal Trophoblast Cancer; Advanced Malignancy Glycoprotein; Wnt Activated Inhibitory Factor 1; TPBG Narnatumab Macrophage Stimulating Protein Receptor; Advanced Malignancy; Solid Tumor CDw136; Protein Tyrosine Kinase 8; p185 Ron; CD136; MST1R; EC 2.7.10.1 Natalizumab Integrin Alpha 4; CD49 Antigen Like Family Acute Ischemic Stroke; Multiple Sclerosis; Rheumatoid Member D; VLA4 Subunit Alpha; CD49d; ITGA4 Arthritis; Paraneoplastic Syndrome; Graft Versus Host Disease (GVHD); Crohn's Disease (Regional Enteritis); Relapsing Remitting Multiple Sclerosis (RRMS) Navicixizumab Delta Like Protein 4; Delta Like Ligand 4; Ovarian Cancer; Uterine Cancer; Fallopian Tube Cancer; Solid Drosophila Delta Homolog 4; DLL4; Vascular Tumor; Metastatic Colorectal Cancer; Peritoneal Cancer Endothelial Growth Factor; VEGF Navivumab Influenza A virus hemagglutinin HA Infectious Disease Ndimab-varB Nerve growth factor Chronic Pancreatitis Pain; Sciatic Pain; Vertebral Fracture Pain; Cancer Pain; Chronic Pain; Osteoarthritis Pain; Low Back Pain Necitumumab Epidermal Growth Factor Receptor; Proto Metastatic Colorectal Cancer; Non-Small Cell Lung Cancer; Oncogene c ErbB 1; Receptor Tyrosine Protein Squamous Non-Small Cell Lung Cancer Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Neliximab V Type Proton Atpase 116 Kda Subunit A Heart Transplant Rejection; Kidney Transplant Rejection; Isoform 3; Osteoclastic Proton Pump 116 kDa Inflammation; Arthritis Subunit; T Cell Immune Regulator 1; T Cell Immune Response cDNA7 Protein; Vacuolar Proton Translocating ATPase 116 kDa Subunit A Isoform 3; TCIRG1; EC 3.6.3.6 Nemolizumab Interleukin 31 Receptor Subunit Alpha; Pruritus; Atopic Dermatitis Cytokine Receptor Like 3; Gp130 Like Monocyte Receptor; GLM R; ZcytoR17; IL31RA Nesvacumab Angiopoietin 2; Ang 2; ANGPT2; Placenta Diabetic Macular Edema; Wet (Neovascular/Exudative) Growth Factor; Vascular Endothelial Growth Macular Degeneration Factor Related Protein; PGF; Vascular Endothelial Growth Factor A; Vascular Permeability Factor; VEGFA; Vascular Endothelial Growth Factor B; VEGF Related Factor; VEGFB Neuradiab Tenascin; Cytotactin; GMEM; GP 150-225; Non-Hodgkin Lymphoma; Glioblastoma Multiforme (GBM); Brain Glioma Associated Extracellular Matrix Cancer Antigen; Hexabrachion; JI; Myotendinous Antigen; Neuronectin; Tenascin C; TNC Nimotuzumab Epidermal Growth Factor Receptor; Proto Gastric Cancer; Glioblastoma Multiforme (GBM); Pediatric Oncogene c ErbB 1; Receptor Tyrosine Protein Diffuse Intrinsic Pontine Glioma; Adenocarcinoma Of The Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Gastroesophageal Junction; Gastric Cancer; Metastatic Adenocarcinoma of The Pancreas; Non-Small Cell Lung Cancer; Nasopharyngeal Cancer; Oropharyngeal Cancer; Cervical Cancer; Metastatic Breast Cancer; Hypopharyngeal Cancer; Squamous Non-Small Cell Lung Carcinoma Nivolumab Programmed Cell Death Protein 1; PDI; CD279; Squamous Non-Small Cell Lung Cancer Metastatic Melanoma; PDCDI Metastatic Renal Cell Carcinoma; Squamous Non-Small Cell Lung Cancer Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Squamous Non-Small Cell Lung Cancer; Transitional Cell Cancer (Urothelial Cell Cancer) Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Metastatic Melanoma; Renal Cell Carcinoma; Squamous Non-Small Cell Lung Cancer Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Squamous Non-Small Cell Lung Cancer Hodgkin Lymphoma (B- Cell Hodgkin Lymphoma); Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Squamous Non-Small Cell Lung Cancer Gastric Cancer Non-Small Cell Lung Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Renal Cell Carcinoma Transitional Cell Cancer (Urothelial Cell Cancer) Malignant Pleural Mesothelioma; Small-Cell Lung Cancer Esophageal Cancer Gastric Cancer; Gastroesophageal (GE) Junction Carcinomas Glioblastoma Multiforme (GBM) Head and Neck Cancer Squamous Cell Carcinoma; Transitional Cell Carcinoma (Urothelial Cell Carcinoma) Head and Neck Carcinoma Hepatocellular Carcinoma; Non-Small Cell Lung Cancer; Renal Cell Carcinoma; Small-Cell Lung Cancer; Transitional Cell Cancer (Urothelial Cell Cancer) Malignant Pleural Mesothelioma; Ovarian Cancer Esophageal Cancer; Gastric Cancer; Gastroesophageal (GE) Junction Carcinomas; Hepatocellular Carcinoma; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Recurrent Glioblastoma Multiforme (GBM); Refractory Multiple Myeloma; Relapsed Multiple Myeloma Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); B-Cell Non-Hodgkin Lymphoma; Bladder Cancer; Chronic Lymphocytic Leukemia (CLL); Pancreatic Ductal Adenocarcinoma; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL) Metastatic Breast Cancer; Ovarian Cancer; Primary CNS Lymphoma; Testicular Cancer Human Papillomavirus Infections Adenocarcinoma; Anal Cancer; Cutaneous T-Cell Lymphoma; Gastric Cancer; Gastroesophageal (GE) Junction Carcinomas; Merkel Cell Carcinoma; Metastatic Colorectal Cancer; Papillary Tumor; Peripheral T-Cell Lymphomas (PTCL); Signet Ring Cell Squamous Cell Carcinoma Cervical Cancer; Nasopharyngeal Cancer; Skin Cancer; Vaginal Cancer; Vulvar Cancer Endometrial Cancer; Fallopian Tube Cancer; Peritoneal Cancer; Primary ENS Lymphoma; Soft Tissue Sarcoma; Testicular Cancer; Uterine Cancer Ovarian Cancer Bladder Cancer Acute Myelocytic Leukemia (AML; Acute Myeloblastic Leukemia); Gastric Cancer Cervical Cancer; Colon Cancer; Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Nasopharyngeal Cancer; Pancreatic Cancer; Skin Cancer; Vaginal Cancer; Vulvar Cancer Sepsis Bile Duct Cancer (Cholangiocarcinoma); Solid Tumor Metastatic Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Non-Small Cell Lung Cancer Hepatitis C Chronic Myelocytic Leukemia (CML; Chronic Myeloid Leukemia) Oral Cavity (Mouth) Cancer Leptomeningeal Disease (Neoplastic Meningitis; Leptomeningeal Carcinomatosis) Metastatic Melanoma Gastric Cancer; Non-Small Cell Lung Cancer; Renal Cell Carcinoma; Small-Cell Lung Cancer Gastroesophageal (GE) Junction Carcinomas Head and Neck Cancer Malignant Pleural Mesothelioma Metastatic Renal Cell Carcinoma Recurrent Glioblastoma Multiforme (GBM) Bladder Cancer; Breast Cancer; Ewing Sarcoma; Hepatocellular Carcinoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Malignant Pleural Mesothelioma; Metastatic Colorectal Cancer; Metastatic Hormone Refractory (Castration Resistant; androgen- Independent) Prostate Cancer; Metastatic Pancreatic Cancer; Metastatic Transitional (Urothelial) Tract Cancer; Metastatic Uveal Melanoma; Neuroblastoma; Non-Hodgkin Lymphoma; Non-Small Cell Lung Cancer; Osteosarcoma; Primitive Neuroectodermal Tumor (PNET); Rhabdomyosarcoma Melanoma Merkel Cell Carcinoma; Metastatic Hrmone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Non-Small Cell Lung Cancer Epithelial Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer Obiltoxaximab Anthrax Protective Antigen; pa Anthrax Obinutuzumab B Lymphocyte Antigen CD20; B Lymphocyte Graft Versus Host Disease (GVHD); Waldenstrom Surface Antigen B1; Bp35; Leukocyte Surface Macroglobulinemia; End-Stage Kidney Disease (End-Stage Antigen Leu 16; Membrane Spanning 4 Renal Disease; ESRD); Diffuse Large B-Cell Lymphoma; Domains Subfamily A Member 1; CD20; MS4A1 Follicular Lymphoma; Splenic Marginal Zone B-Cell Lymphoma Lupus Nephritis; Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia (CLL); Follicular Lymphoma Ocaratuzumab B Lymphocyte Antigen CD20: B Lymphocyte Follicular Lymphoma; Lymphoma; Rheumatoid Arthritis; Surface Antigen B1; Bp35; Leukocyte Surface Systemic Lupus Erythematosus; Chronic Lymphocytic Antigen Leu 16; Membrane Spanning 4 Leukemia (CLL) Domains Subfamily A Member 1; CD20; MS4A1 Ocrelizumab B Lymphocyte Antigen CD20; B Lymphocyte Follicular Lymphoma; Rheumatoid Arthritis; Lupus Nephritis; Surface Antigen B1; Bp35; Leukocyte Surface Systemic Lupus Erythematosus; Primary Progressive Multiple Antigen Leu 16; Membrane Spanning 4 Sclerosis (PPMS); Relapsing Multiple Sclerosis (RMS); Domains Subfamily A Member 1; CD20; MS4A1 Odulimomab Integrin Alpha L; CD11 Antigen Like Family Multiple Sclerosis; Graft Versus Host Disease (GVHD); Kidney Member A; Leukocyte Adhesion Glycoprotein Transplant Rejection LFA 1 Alpha Chain; CD11a; ITGAL Ofatumumab CD20; B Lymphocyte Surface Antigen B1; Relapsing Remitting Multiple Sclerosis (RRMS); Secondary Bp35; Leukocyte Surface Antigen Leu 16; Progressive Multiple Sclerosis (SPMS) B-Cell Non-Hodgkin Membrane Spanning 4 Domains Subfamily A Lymphoma; Neuromyelitis Optica (Devic's Syndrome); Member 1; CD20; MS4A1 Rheumatoid Arthritis; Diffuse Large B-Cell Lymphoma; Diffuse Large B-Cell Lymphoma; Waldenstrom Macroglobulinemia; Pemphigus Vulgaris; Rheumatoid Arthritis; Refractory Chronic Lymphocytic Leukemia (CLL); Chronic Lymphocytic Leukemia (CLL); Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL)” Olaratumab Platelet Derived Growth Factor Receptor; Epithelial Ovarian Cancer; Fallopian Tube Cancer; PDGFR; EC 2.7.10.1; Platelet Derived Growth Gastrointestinal Stromal Tumor (GIST); Metastatic Hormone Factor Receptor Alpha; Alpha Type Platelet Refractory (Castration Resistant; androgen-Independent) Derived Growth Factor Receptor; CD140 Prostate Cancer; Peritoneal Cancer; Recurrent Glioblastoma Antigen Like Family Member A; Platelet Multiforme (GBM); Metastatic Pancreatic Cancer; Non-Small Derived Growth Factor Receptor 2; CD140a; Cell Lung Cancer; Soft Tissue Sarcoma PDGFRA; EC 2.7.10.1 Oleclumab 5′ Nucleotidase; Ecto 5′ Nucleotidase; CD73; Colorectal Cancer; Pancreatic Cancer NT5E; EC 3.1.3.5 Olokizumab Interleukin 6; B Cell Stimulatory Factor 2; Rheumatoid Arthritis; Crohn's Disease (Regional Enteritis) BSF2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta 2; IFNB2; IL6 Omalizumab Immunoglobulin E; IgE Kidney Disease; Rhino-Conjunctivitis; Nasal Polyposis; Rhinosinusitis; Asthma; Allergic Asthma; Chronic Urticaria; Hives Onartuzumab Hepatocyte Growth Factor Receptor; Proto Gastric Cancer; Hepatocellular Carcinoma; Metastatic Breast Oncogene c Met; Tyrosine Protein Kinase Met; Cancer; Metastatic Colorectal Cancer; Non-Small Cell Lung HGF/SF Receptor; Scatter Factor Receptor; Cancer; Recurrent Glioblastoma Multiforme (GBM); Non-Small MET; EC 2.7.10.1 Cell Lung Cancer; Metastatic Melanoma; Recurrent Glioblastoma Multiforme (GBM) Ontuxizumab Endosialin; Tumor Endothelial Marker 1; CD164 Metastatic Melanoma; Solid Tumor; Metastatic Colorectal Sialomucin Like 1; CD248 Cancer; Rhabdomyosarcoma; Soft Tissue Sarcoma; Lymphoma Opicinumab Leucine Rich Repeat and Immunoglobulin Like Optic Neuritis; Relapsing Remitting Multiple Sclerosis (RRMS); Domain Containing Nogo Receptor Interacting Secondary Progressive Multiple Sclerosis (SPMS) Protein 1; Leucine Rich Repeat and Immunoglobulin Domain Containing Protein 1; Leucine Rich Repeat Neuronal Protein 1; Leucine Rich Repeat Neuronal Protein 6A; LINGOI Oportuzumab Epithelial Cell Adhesion Molecule; Head and Neck Cancer Squamous Cell Carcinoma; Ovarian monatox Adenocarcinoma Associated Antigen; Cell Cancer; Liver Cancer; Non Muscle Invasive Bladder Cancer Surface Glycoprotein Trop 1; Epithelial Cell (NMIBC) (Superficial Bladder Cancer) Surface Antigen; Epithelial Glycoprotein 314; KS ¼ Antigen; KSA; Tumor Associated Calcium Signal Transducer 1; CD326; EPCAM Oregovomab Mucin 16; Ovarian Cancer Related Tumor Epithelial Ovarian Cancer; Fallopian Tube Cancer; Ovarian Marker CA125; Ovarian Carcinoma Antigen Cancer; Pancreatic Ductal Adenocarcinoma; Peritoneal Cancer CA125; MUC16 Oreptacog, rFVIIa Hamophilie Oreptacog alfa Orticumab Oxidized low-density lipoprotein Atherosclerosis Otelixizumab T Cell Surface Glycoprotein CD3 Epsilon Graves' Ophthalmopathy; Type 1 Diabetes (Juvenile Diabetes); Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Myasthenia Gravis; Psoriasis; Rheumatoid Arthritis Chain; CD3E Otlertuzumab Leukocyte Antigen CD37; Tetraspanin 26; B-Cell Non-Hodgkin Lymphoma; Follicular Lymphoma; CD37 Lymphoblastic Lymphoma; Non-Hodgkin Lymphoma; Relapsed Chronic Lymphocytic Leukemia (CLL); Chronic Lymphocytic Leukemia (CLL) Oxelumab Tumor Necrosis Factor Ligand Superfamily Asthma Member 4; Glycoprotein Gp34; OX40 Ligand; TAX Transcriptionally Activated Glycoprotein 1; CD252; TNFSF4 Ozanezumab Reticulon 4; Human NogoA; Neurite Outgrowth Amyotrophic Lateral Sclerosis; Relapsing Remitting Multiple Inhibitor; Foocen; Neuroendocrine Specific Sclerosis (RRMS) Protein; Neuroendocrine Specific Protein C Homolog; RTN x; Reticulon 5; RTN4 Ozoralizumab Tumor Necrosis Factor; Cachectin; TNF Alpha; Rheumatoid Arthritis Tumor Necrosis Factor Ligand Superfamily Member 2; TNF a; TNF Pagibaximab Lipoteichoic Acid; LTA Bacterial Sepsis; Staphylococcal Infections Palivizumab Respiratory Syncytial Virus Fusion Protein; Respiratory Syncytial Virus (RSV) Infections RSV F Protein Pamrevlumab Connective Tissue Growth Factor; CCN Family Duchenne Muscular Dystrophy; Pancreatic Ductal Member 2; Hypertrophic Chondrocyte Adenocarcinoma; Idiopathic Pulmonary Fibrosis; Liver Fibrosis; Specific Protein 24; Insulin Like Growth Focal Segmental Glomerulosclerosis (FSGS); Microalbuminuria; Factor Binding Protein B; IGFBPB; CTGF Proteinuria; Systemic Sclerosis (Scleroderma); Diabetic Nephropathy; Type 1 Diabetes (Juvenile Diabetes); Type 2 Diabetes Panitumumab Epidermal Growth Factor Receptor; Proto Esophageal Cancer; Adenocarcinoma Of The Gastroesophageal Oncogene c ErbB 1; Receptor Tyrosine Protein Junction; Gastric Cancer; Metastatic Breast Cancer; Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Anal Cancer; Non-Small Cell Lung Cancer; Glioblastoma Multiforme (GBM); Gliosarcoma; Malignant Glioma; Muscle Invasive Bladder Cancer (MIBC); Non-Small Cell Lung Cancer; Renal Cell Carcinoma; Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Colorectal Cancer Pankomab, Mucin 1; Breast Carcinoma Associated Antigen Fallopian Tube Cancer; Epithelial Ovarian Cancer; Peritoneal Pankoab DF3; Episialin; H23AG; Krebs Von Den Lungen Cancer; Breast Cancer; Non-Small Cell Lung Cancer; 6; PEMT; Peanut Reactive Urinary Mucin; Colorectal Cancer; Ovarian Cancer Polymorphic Epithelial Mucin; Tumor Associated Epithelial Membrane Antigen; Tumor Associated Mucin; CD227; MUC1; tumor specific glycosylation of MUC1 Panobacumab Lipopolysaccharide; Endotoxin Ventilator Associated Pneumonia (VAP); Hospital Acquired Pneumonia (HAP); Pseudomonas aeruginosa Pneumonia Parsatuzumab Epidermal Growth Factor Like Protein 7; Solid Tumor; Metastatic Colorectal Cancer; Non-Small Cell Multiple Epidermal Growth Factor Like Lung Cancer; Solid Tumor Domains Protein 7; NOTCH4 Like Protein; Vascular Endothelial Statin; Zneu1; EGFL7 Pascolizumab Interleukin 4; B Cell Stimulatory Factor 1; Asthma Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4 Pasotuxizumab Glutamate Carboxypeptidase 2; Folate Hormone Refractory (Castration Resistant; androgen- Hydrolase 1; Prostate Specific Membrane Independent) Prostate Cancer Antigen; PSMA; Pteroylpoly Gamma Glutamate Carboxypeptidase; Cell Growth Inhibiting Gene 27 Protein; FOLH1; EC 3.4.17.21; T Cell Surface Glycoprotein CD3 Epsilon Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; CD3E Pateclizumab Lymphotoxin Alpha; TNF Beta; Tumor Necrosis Rheumatoid Arthritis Factor Ligand Superfamily Member 1; LTA Patritumab Receptor Tyrosine Protein Kinase ERBB 3; Non-Small Cell Lung Cancer; Breast Cancer; Bladder Cancer; Proto Oncogene Like Protein c ErbB 3; Cervical Cancer; Colon Cancer; Endometrial Cancer; Tyrosine Kinase Type Cell Surface Receptor Esophageal Cancer; Gastric Cancer; Liver Cancer; Ovarian HER3; HER3; ERBB3; EC 2.7.10.1 Cancer; Pancreatic Cancer; Prostate Cancer; Metastatic Breast Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma Pembrolizumab Programmed Cell Death Protein 1; PD1; CD279; Metastatic Melanoma; Non-Small Cell Lung Cancer Metastatic PDCD1 Melanoma; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Metastatic Melanoma; Non-Small Cell Lung Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Melanoma; Non-Small Cell Lung Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Colorectal Cancer; Metastatic Transitional (Urothelial) Tract Cancer; Non-Small Cell Lung Cancer; Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Adenocarcinoma Of The Gastroesophageal Junction; Gastric Cancer; Breast Cancer; Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma; Multiple Myeloma (Kahler Disease); Refractory Multiple Myeloma; Non-Small Cell Lung Cancer Adenocarcinoma Of The Gastroesophageal Junction; Esophageal Cancer; Gastric Cancer; Hepatocellular Carcinoma; Hypopharyngeal Cancer; Laryngeal Cancer; Metastatic Transitional (Urothelial) Tract Cancer; Oral Cavity (Mouth) Cancer; Oropharyngeal Cancer; Refractory Multiple Myeloma; Ureter Cancer; Urethral Cancer Bladder Cancer; Recurrent Head and Neck Cancer Squamous Cell Carcinoma Adenocarcinoma Of The Gastroesophageal Junction; Esophageal Cancer; Mantle Cell Lymphoma; Merkel Cell Carcinoma; Metastatic Biliary Tract Cancer; Small-Cell Lung Cancer; Squamous Cell Carcinoma Anal Cancer; Basal Cell Carcinoma (Basal Cell Epithelioma); Cervical Cancer; Chondrosarcoma; Dedifferentiated Liposarcoma; Diffuse Large B-Cell Lymphoma; Endometrial Cancer; Epithelial Ovarian Cancer; Ewing Sarcoma; Fallopian Tube Cancer; Follicular Lymphoma; Germinomatous (Seminomatous) Germ Cell Tumors; Gliosarcoma; Leiomyosarcoma; Lymphoma; Malignant Pleural Mesothelioma; Metastatic Colorectal Cancer; Metastatic Prostate Cancer; Metastatic Renal Cell Carcinoma; Nasopharyngeal Cancer; Neuroblastoma; Neuroendocrine Tumors; Non Muscle Invasive Bladder Cancer (NMIBC) (Superficial Bladder Cancer); Non-Hodgkin Lymphoma; Nongerminomatous (Nonseminomatous) Germ Cell Tumors; Osteosarcoma; Pancreatic Cancer; Peripheral Nerve Sheath Tumor (Neurofibrosarcoma); Peritoneal Cancer; Primary Mediastinal B-Cell Lymphoma; Recurrent Glioblastoma Multiforme (GBM); Salivary Gland Cancer; Small-Cell Lung Cancer; Soft Tissue Sarcoma; Synovial Sarcoma; T-Cell Lymphomas; Thymic Carcinoma; Thyroid Cancer Adenoid Cystic Carcinoma (ACC); Chronic Idiopathic Myelofibrosis; Chronic Lymphocytic Leukemia (CLL); Diffuse Large B-Cell Lymphoma; Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF); Post-Polycythemia Vera Myelofibrosis (PPV-MF); Small-Cell Lung Cancer; Soft Tissue Sarcoma Metastatic Melanoma Chronic Lymphocytic Leukemia (CLL); Lymphoma; Mycosis Fungoides; Myelodysplastic Syndrome; Non-Hodgkin Lymphoma; Sezary Syndrome Melanoma; Metastatic Breast Cancer; Neuroendocrine Gastroenteropancreatic Tumors (GEP-NET) Perakizumab Interleukin 17; IL17 Psoriatic Arthritis; Autoimmune Disorders; Inflammation; Rheumatoid Arthritis Pertuzumab, Receptor Tyrosine Protein Kinase ERBB 2; Non-Small Cell Lung Cancer; Pancreatic Cancer; Hormone Pertuzuab Metastatic Lymph Node Gene 19 Protein; Proto Refractory (Castration Resistant; androgen-Independent) Oncogene Neu; Proto Oncogene C ErbB 2; Prostate Cancer; Neuroendocrine Cancer; Adenocarcinoma Of Tyrosine Kinase Type Cell Surface Receptor The Gastroesophageal Junction; Breast Cancer; Epithelial HER2; pI85erbB2; HER2; CD340; ERBB2; EC Ovarian Cancer; Fallopian Tube Cancer; Gastric Cancer; 2.7.10.1; HER2/neu Metastatic Breast Cancer; Peritoneal Cancer; Breast Cancer; Metastatic Breast Cancer Pexelizumab, Complement C5; C3 and PZP Like Alpha 2 Coronary Disease; Myocardial Infarction; Reduction of Side Pexelizumab Macroglobulin Domain Containing Protein 4; Effects of Cardiac Surgery h5g1.1 C5 PF-05082566, Tumor Necrosis Factor Receptor Superfamily Non-Small Cell Lung Cancer; Colorectal Cancer; Metastatic Utomilumab Member 9; 4-IBB Ligand Receptor; T Cell Breast Cancer; Small-Cell Lung Cancer; Head and Neck Cancer Antigen 4-IBB Homolog; T Cell Antigen ILA; Squamous Cell Carcinoma; Metastatic Melanoma; Ovarian CD137; TNFRSF9 Cancer; Renal Cell Carcinoma; Follicular Lymphoma; Cervical Cancer; Pancreatic Cancer; Gastric Cancer; Bladder Cancer; Diffuse Large B-Cell Lymphoma; Sarcomas; Anaplastic Thyroid Cancer; Metastatic Hepatocellular Carcinoma (HCC); Thymoma (Thymic Epithelial Tumor) Pidilizumab Programmed Cell Death 1; PD-1; PDCD1; Pontine Glioma; Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Hepatitis C; Hepatocellular Carcinoma; Metastatic Colorectal Cancer; Pancreatic Cancer Pinatuzumab, B Cell Receptor CD22; B Lymphocyte Cell Follicular Lymphoma; Chronic Lymphocytic Leukemia (CLL); Pinatuzumab Adhesion Molecule; Sialic Acid Binding Ig Like Diffuse Large B-Coll Lymphoma vedotin Lectin 2; T Cell Surface Antigen Lou 14; CD22 Placulumab Tumor Necrosis Factor; Cachectin; TNF Alpha; Sciatica; Plague Psoriasis (Psoriasis Vulgaris); Rheumatoid Tumor Necrosis Factor Ligand Superfamily Arthritis Member 2; TNF a; TNF Plozalizumab C-C Chemokine Receptor Type 2; Monocyte Rheumatoid Arthritis; Bone Metastasis; Diabetic Nephropathy; Chemoattractant Protein 1 Receptor; CD192; Relapsing Remitting Multiple Sclerosis (RRMS); CCR2 Atherosclerosis; Melanoma; Solid Tumor Pogalizumab Tumor Necrosis Factor Receptor Superfamily Solid Tumor; Metastatic Transitional (Urothelial) Tract Cancer Member 4; ACT35 Antigen; TAX Transcriptionally Activated Glycoprotein 1 Receptor; DX40L Receptor; CD134; TNFRSF4 Polatuzumab, B Cell Antigen Receptor Complex Associated Follicular Lymphoma; Diffuse Large B-Cell Lymphoma; B-Cell Polatuzumab Protein Beta Chain; B Cell Specific Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia (CLL); vedotin, Glycoprotein B29; Ig Beta; Immunoglobulin Mantle Cell Lymphoma Polatuzuab Associated B29 Protein; CD79B Ponezumab Amyloid Beta Peptide; A beta P; Abeta; Beta Alzheimer's Disease; Neurodegenerative Diseases Amyloid Porgaviximab Ebolavirus glycoprotein Ebola virus infections Prezalumab ICOS Ligand; B7 Homolog 2; B7 Like Protein Subacute Cutaneous Lupus Erythematosus (SCLE); Psoriasis; G150; B7 Related Protein 1; CD275; ICOSLG Systemic Lupus Erythematosus; Sicca Syndrome (Sjogren) Pritoxaximab Shiga Toxin Type 1; stx1; Shiga Toxin Type 2; Escherichia coli Infections; Typical Hemolytic Uremic stx2 Syndrome (Shiga-Toxin Associated Hemolytic Uremic Syndrome); Typical Hemolytic Uremic Syndrome (Shiga-Toxin Associated Hemolytic Uremic Syndrome) Pritumumab Vimentin; Epididymis Luminal Protein 113; VIM Glioma; Pancreatic Cancer Duilizumab Immunoglobulin E; IgE Allergic Asthma; Allergic Rhinitis; Chronic Urticaria; Hives Racotumomab N Glycolylneuraminyl Lactosylceramide; Breast Cancer; Melanoma; Small-Cell Lung Cancer; Ewing NeuGcGM3 Sarcoma; Glioma; Retinoblastoma; Wilms' Tumor (Nephroblastoma); Neuroblastoma; Non-Small Cell Lung Cancer Radretumab Fibronectin; Cold Insoluble Globulin; FN1 Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Lung Cancer; Prostate Cancer; Metastatic Brain Tumor; Non-Small Cell Lung Cancer; Colorectal Cancer Rafivirumab Rabies Virus Glycoprotein Rabies Ralpancizumab Neural Apoptosis-regulated Proteinase 1 dyslipidemia; Hypercholesterolemia; Hyperlipidemia Ramucirumab Vascular Endothelial Growth Factor Receptor Adenocarcinoma Of The Gastroesophageal Junction; Gastric 2; Fetal Liver Kinase 1; Kinase Insert Domain Cancer; Metastatic Colorectal Cancer; Non-Small Cell Lung Receptor; Protein Tyrosine Kinase Receptor Cancer; Gastric Cancer; Metastatic Colorectal Cancer; Non- flk 1; VEGFR2; CD309; KDR; EC 2.7.10.1 Small Cell Lung Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Gallbladder Cancer; Metastatic Biliary Tract Cancer; Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma; Peritoneal Tumor; Mantle Cell Lymphoma; Neuroendocrine Tumors; Hepatocellular Carcinoma; Metastatic Hormone Refractory (Castration Resistant; androgen- Independent) Prostate Cancer; Metastatic Melanoma; Recurrent Glioblastoma Multiforme (GBM); Metastatic Breast Cancer Ranevetmab Canine Nerve Growth Factor; NGF Pain; Osteoarthritis Ranibizumab, Vascular Endothelial Growth Factor Receptor Retinal Vein Occlusion; Age Related Macular Degeneration; Ranibizivab 2; Fetal Liver Kinase 1; Kinase Insert Domain Diabetic Macular Edema; Diabetic Macular Edema; Diabetic Receptor; Protein Tyrosine Kinase Receptor Retinopathy; Non-Proliferative Diabetic Retinopathy (NPDR); flk 1; VEGFR2; CD309; KDR; EC 2.7.10.1; VEGF-A Proliferative Diabetic Retinopathy (PDR); Choroidal Neovascularization; Macular Edema; Wet (Neovascular/ Exudative) Macular Degeneration; Macular Edema; Wet (Neovascular/Exudative) Macular Degeneration; Retinopathy Of Prematurity; Epistaxis; Corneal Neovascularization; Cystoid Macular Edema; Macular Edema; Polypoidal Choroidal Vasculopathy; Pterygium; Retinal Vein Occlusion; Uveitis Raxibacumab Anthrax Protective Antigen; pa Anthrax Refanezumab Myelin Associated Glycoprotein; Siglec 4a; Ischemic Stroke Sialic Acid Binding Ig Like Lectin 4A; MAG Regavirumab Human Cytomegalovirus Envelope Cytomegalovirus (HHV-5) Infections Glycoprotein B; gB REGN2810 Programmed Cell Death Protein 1; PD1; CD279; Melanoma; Squamous Cell Carcinoma; Non-Small Cell Lung PDCD1 Cancer; Acute Lymphocytic Leukemia (ALL; Acute Lymphoblastic Leukemia); Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma); Solid Tumor; B-Cell Non-Hodgkin Lymphoma; Basal Cell Carcinoma (Basal Cell Epithelioma) Remtolumab Interleukin 17A; Cytotoxic T Lymphocyte Rheumatoid Arthritis; Psoriatic Arthritis; Systemic-Onset Associated Antigen B; CTLA8; IL17A; Tumor Juvenile Idiopathic Arthritis (Still Disease) Necrosis Factor; Cachectin; TNF Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF a; TNF Reslizumab Interleukin 5; Eosinophil Differentiation Asthma; Churg-Strauss Syndrome; Hypereosinophilic Factor; B Cell Differentiation Factor 1; T Cell Syndrome; Eosinophilic Esophagitis Replacing Factor; IL5 rhuMAb-VEGF Vascular Endothelial Growth Factor A; Breast Cancer; Lung Cancer; Ovarian Cancer; Glioblastoma Vascular Permeability Factor; VEGFA Multiforme (GBM); Glioma; Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Fallopian Tube Cancer; Epithelial Ovarian Cancer; Colorectal Cancer; Cervical Cancer; Metastatic Breast Cancer; Malignant Glioma; Metastatic Colorectal Cancer; Metastatic Ovarian Cancer; Metastatic Renal Cell Carcinoma; Peritoneal Cancer Rilotumumab Hepatocyte Growth Factor; Hepatopoietin A; Adenocarcinoma Of The Gastroesophageal Junction; Gastric Scatter Factor; HGF Cancer; Gliosarcoma; Metastatic Colorectal Cancer; Metastatic Hormone Refractory (Castration Resistant; androgen- Independent) Prostate Cancer; Metastatic Renal Cell Carcinoma; Non-Small Cell Lung Cancer; Recurrent Glioblastoma Multiforme (GBM); Recurrent Malignant Glioma; Small-Cell Lung Cancer Rinucumab Placenta Growth Factor; Vascular Endothelial Wet (Neovascular/Exudative) Macular Degeneration Growth Factor Related Protein; PGF; Platelet Derived Growth Factor Receptor Beta; Beta Type Platelet Derived Growth Factor Receptor; CD140 Antigen Like Family Member B; Platelet Derived Growth Factor Receptor 1; CD140b; PDGFRB; EC 2.7.10.1; Vascular Endothelial Growth Factor A; Vascular Permeability Factor; VEGFA; Vascular Endothelial Growth Factor B; VEGF Related Factor; VEGFB Risankizumab Interleukin 23; IL23 Asthma; Ulcerative Colitis; Ankylosing Spondylitis (Bekhterev's Disease); Psoriatic Arthritis; Plaque Psoriasis (Psoriasis Vulgaris; Crohn's Disease (Regional Enteritis) Rituximab B Lymphocyte Antigen CD20; B Lymphocyte B-Cell Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia Surface Antigen B1; Bp35; Leukocyte Surface (CLL); Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Antigen Lau 16; Membrane Spanning 4 Non-Hodgkin Lymphoma; Microscopic Polyangiitis (MPA); Domains Subfamily A Member 1; CD20; MS4A1 Granulomatosis with Polyangiitis (Wegener Polyangiitis); Rheumatoid Arthritis; Vasculitis; Nephrotic Syndrome; Pemphigus Vulgaris; Neuromyelitis Optice (Devic's Syndrome); Glomerulonephritis; Idiopathic Thrombocytopenic Purpura (Immune Thrombocytopenic Purpura); Kidney Transplant Rejection; Liver Transplant Rejection; Thrombotic Thrombocytopenic Purpura; Hemophilia A; Lupus Nephritis; Myasthenia Gravis; Sicca Syndrome (Sjogren); Systemic Lupus Erythematosus; Autoimmune Disease Rivabazumab, Pseudomonas aeruginosa type III secrection Pseudomonas aeruginosa infection Rivabazumab system; ttss pcrv protein pegol Robatumumab Insulin Like Growth Factor 1; Mechano Growth Colorectal Cancer; Ewing Sarcoma; Osteosarcoma; Solid Factor; Somatomedin C; IGF1 Tumor Roledumab Blood Group Rh(D Polypeptide; RHXIII; Rh Erythroblastosis Fetalis (Hemolytic Disease In Newborns) Polypeptide 2; Rhesus D Antigen; CD240D; RHD Romosozumab Sclerostin; SOST Post Menopausal Osteoporosis; Osteopenia; Bone Fracture; Osteoporosis Rontalizumab, Interferon Alpha/Beta Receptor I; Cytokine Systemic Lupus Erythematosus Rontalizuab Receptor Class II Member I; Cytokine Receptor Family 2 Member I; Type I Interferon Receptor I; IFNAR1; Interferon Alpha/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2; IFN-α Rosmantuzumab R Spondin 3; Roof Plate Specific Spondin 3; Solid Tumor; Metastatic Colorectal Cancer; Lung Cancer; Protein With TSP Type I Repeat; Ovarian Cancer; Pancreatic Cancer Thrombospondin Type I Domain Containing Protein 2; RSPO3 Rovalpituzumab, Delta Like Protein 3; Drosophila Delta Graft Versus Host Disease (GVHD); Small-Cell Lung Cancer; Rovalpituzumab Homolog 3; DLL3 Prostate Cancer; Glioblastoma Multiforme (GBM); Melanoma; tesirine Pancreatic Cancer; Gastric Cancer; Small-Cell Lung Cancer; Medullary Thyroid Cancer; Neuroendocrine Carcinoma; Small- Cell Lung Cancer Rovelizumab Integrin Beta 2; Cell Surface Adhesion Multiple Sclerosis; Hemorrhagic Shock; Ischemic Stroke; Glycoproteins LFA-1/CR3/p150; 95 Subunit Myocardial Infarction; Restenosis; Cerebral Vasospasm; Kidney Beta; Complement Receptor C3 Subunit Beta; Transplant Rejection; Brain (Head) Trauma CD18; ITGB2 Rozanolixizumab FCGRT; FCRN Receptor Myasthenia Gravis; Idiopathic Thrombocytopenic Purpura (Immune Thrombocytopenic Purpura) Ruplizumab CD40 Ligand; T Cell Antigen Gp39; TNF Related Glomerulonephritis; Kidney Transplant Rejection; Lupus Activation Protein; Tumor Necrosis Factor Nephritis; Transplant Rejection Ligand Superfamily Member 5; CD154; CD40LG Sacituzumab, Tumor Associated Calcium Signal Transducer Neuromyelitis Optica (Devic's Syndrome); Breast Cancer; Lung Sacituzumab 2; Cell Surface Glycoprotein Trop 2; Cancer; Ovarian Cancer; Glioblastoma Multiforme (GBM); govitecan Membrane Component Chromosome I Surface Kidney Cancer (Renal Cell Cancer); Non-Small Cell Lung Marker I; Pancreatic Carcinoma Marker Cancer; Esophageal Cancer; Epithelial Tumor; Colorectal Protein GA733-I; TACSTD2 Cancer; Cervical Cancer; Gastric Cancer; Bladder Cancer; Metastatic Breast Cancer; Small-Cell Lung Cancer; Endometrial Cancer; Colon Cancer; Follicular Thyroid Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Hepatocellular Carcinoma; Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Pancreatic Ductal Adenocarcinoma; Transitional Cell Cancer (Urothelial Cell Cancer) Samalizumab OX 2 Membrane Glycoprotein; MOX1; MOX2; Acute Myelocytic Leukemia (AML; Acute Myeloblastic MRC; CD200 Leukemia); Refractory Acute Myeloid Leukemia; Relapsed Acute Myeloid Leukemia; Solid Tumor; B-Cell Chronic Lymphocytic Leukemia; Multiple Myeloma (Kahler Disease) Sapelizumab Interleukin 6 Receptor; IL6R Rheumatoid Arthritis; Neuromyelitis Optica (Devic's Syndrome) Sarilumab Interleukin 6 Receptor; IL6R Oligoarticular Idiopathic Juvenile Arthritis; Polyarticular Juvenile Idiopathic Arthritis (PJIA); Systemic-Onset Juvenile Idiopathic Arthritis (Still Disease); Ankylosing Spondylitis (Bekhterev's Disease); Intermediate Uveitis; Posterior Uveitis; Uveitis; Rheumatoid Arthritis Satumomab, Insulin Receptor; IR; CD220; INSR; EC 2.7.10.1; Type 1 Diabetes (Juvenile Diabetes); Type 2 Diabetes; Cancer Satumomab TAG-72 (Diagnosis) pendetide Secukinumab Interleukin 17; IL17; Interleukin 17A; Cytotoxic T Axial Spondyloarthritis; Psoriasis; Ankylosing Spondylitis Lymphocyte Associated Antigen B; CTLA8; (Bekhterev's Disease); Psoriatic Arthritis; Plaque Psoriasis IL17A (Psoriasis Vulgaris); Congenital Ichthyosis; Netherton Syndrome (Trichorrhexis Invaginata; Bamboo Hair); Systemic- Onset Juvenile Idiopathic Arthritis (Still Disease); Alopecia; Atopic Dermatitis; Contact Dermatitis; Crohn's Disease (Regional Enteritis); Neutrophilia; Type I Diabetes (Juvenile Diabetes); Keratoconjunctivitis sicca (Dry Eye); Relapsing Multiple Sclerosis (RMS); Relapsing Remitting Multiple Sclerosis (RRMS); Uveitis; Rheumatoid Arthritis; Asthma Selicrelumab CD40; tumor necrosis factor receptor Solid Cancer superfamily member 5; TNFRSF5 Senlizumab Tumor Necrosis Factor; Cachectin; TNF Alpha; Septic Shock; Crohn's Disease (Regional Enteritis) Tumor Necrosis Factor Ligand Superfamily Member 2; TNF a; TNF Seribantumab Receptor Tyrosine Protein Kinase ERBB 3; Bile Duct Cancer (Cholangiocarcinoma); Breast Cancer; Proto Oncogene Like Protein c ErbB 3; Endometrial Cancer; Epithelial Ovarian Cancer; Fallopian Tube Tyrosine Kinase Type Cell Surface Receptor Cancer; Metastatic Breast Cancer; Ovarian Cancer; Peritoneal HER3; HER3; ERBB3; EC 2.7.10.1 Cancer; Solid Tumor; Colorectal Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Non-Small Cell Lung Cancer Setoxaximab Shiga Toxin Type 2; stx2 Escherichia coli Infections; Typical Hemolytic Bromic Syndrome (Shiga-Toxin Associated Hemolytic Uremic Syndrome) Sevirumab Human Cytomegalovirus Glycoprotein H; gH Cytomegalovirus (CMV) Retinitis; Cytomegalovirus (HHV-5) Infections Sibrotuzumab Prolyl Endopeptidase FAP; 170 kDa Melanoma Metastatic Colorectal Cancer; Non-Small Cell Lung Cancer Membrane Bound Gelatinase; Dipeptidyl Peptidase FAP; Integral Membrane Serine Protease; Fibroblast Activation Protein Alpha; Gelatine Degradation Protease FAP; Seprase; FAP; EC 3.4.21.26; EC 3.4.14.5 Sifalimumab Interferon Alpha; IFNA Systemic Lupus Erythematosus; Dermatomyositis; Polymyositis; Plaque Psoriasis (Psoriasis Vulgaris) Siltuximab Interleukin 6; B Cell Stimulatory Factor 2; B-Cell Non-Hodgkin Lymphoma; Metastatic Hormone BSF2; CTL Differentiation Factor; CDF; Refractory (Castration Resistant; androgen-Independent) Hybridoma Growth Factor; Interferon Beta 2; Prostate Cancer; Metastatic Renal Cell Carcinoma; IFNB2; IL6 Myelodysplastic Syndrome; Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Multiple Myeloma (Kahler Disease); Giant Lymph Node Hyperplasia (Castleman's Disease) Simtuzumab Lysyl Oxidase Homolog 2; Lysyl Oxidase Like Idiopathic Pulmonary Fibrosis; Adenocarcinoma; Metastatic Protein 2; Lysyl Oxidase Related Protein 2; Adenocarcinoma of The Pancreas; Metastatic Colorectal Lysyl Oxidase Related Protein WS9-14; LOXL2; Cancer; Myelofibrosis; Post-Polycythemia Vera Myelofibrosis EC 1.4.3.13 (PPV-MF); Thrombocythemia Myelofibrosis; Liver Cirrhosis; Liver Fibrosis; Non-Alcoholic Steatohepatitis; Primary Sclerosing Cholangitis Siplizumab T Cell Surface Antigen CD2; Erythrocyte Leukemias; Natural Killer Cell Lymphomas; Kidney Disease; Receptor; LFA2; LFA3 Receptor; Rosette Graft Versus Host Disease (GVHD); Kidney Transplant Receptor; T Cell Surface Antigen T11/Leu 5; Rejection; Plaque Psoriasis (Psoriasis Vulgaris); Cutaneous T- CD2 Cell Lymphoma; Peripheral T-Cell Lymphomas (PTCL); T-Cell Lymphomas Sirukumab Interleukin 6; B Cell Stimulatory Factor 2; Rheumatoid Arthritis; Giant Cell Arteritis; Major Depressive BSF2; CTL Differentiation Factor; CDF; Disorder; Polymyalgia Rheumatica; Asthma; Cutaneous Lupus Hybridoma Growth Factor; Interferon Beta 2; Erythematosus; Systemic Lupus Erythematosus; Lupus IFNB2; IL6 Nephritis Sofituzumab Mucin 16; Ovarian Cancer Related Tumor Ovarian Cancer; Fallopian Tube Cancer; Epithelial Ovarian vedotin Marker CA125; Ovarian Carcinoma Antigen Cancer; Pancreatic Cancer; Peritoneal Cancer CA125; MUC16 Solanezumab Amyloid Beta Peptide; A beta P; Abeta; Beta Alzheimer's Disease; Dementia Associated With Alzheimer's Amyloid Disease Solitomab Epithelial Cell Adhesion Molecule; Adenocarcinoma Of The Gastroesophageal Junction; Breast Adenocarcinoma Associated Antigen; Cell Cancer; Colorectal Cancer; Gastric Cancer; Hormone Surface Glycoprotein Trop 1; Epithelial Cell Refractory (Castration Resistant; androgen-Independent) Surface Antigen; Epithelial Glycoprotein 314; Prostate Cancer; Lung Adenocarcinoma; Ovarian Cancer; KS ¼ Antigen; KSA; Tumor Associated Small-Cell Lung Cancer; Solid Tumor Calcium Signal Transducer 1; CD326; EPCAM; T Cell Surface Glycoprotein CD3 Epsilon Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; CD3E Sonepcizumab Sphingosine 1-Phosphate Receptor 1; Choroidal Neovascularization; Retinal Pigment Epithelial (RPE) Endothelial Differentiation G Protein Coupled Detachment; Wet (Neovascular/Exudative) Macular Receptor 1; Sphingosine 1 Phosphate Receptor Degeneration; Renal Cell Carcinoma; Solid Tumor; Diabetic Edg 1; CD363; SIPRI Retinopathy; Multiple Sclerosis; Colitis Sontuzumab Mucin 1; Breast Carcinoma Associated Antigen Advanced Malignancy; Breast Cancer DF3; Episialin; H23AG; Krebs Von Den Lungen 6; PEMT; Peanut Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Tumor Associated Epithelial Membrane Antigen; Tumor Associated Mucin; CD227; MUC1 Stamulumab Growth/Differentiation Factor 8; Myostatin; Muscular Dystrophy GDF8; MSTN Suptavumab Respiratory Syncytial Virus Fusion Protein; Respiratory Syncytial Virus (RSV) Infections RSV F Protein Suvizumab Human Immunodeficiency Virus Type 1; HIV-1 Human Immunodeficiency Virus (HIV) Infections (AIDS) envelope glycoprotein gp120 third variable loop V3 Suvratoxumab Staphylococcus aureus Alpha Hemolysin; Staphylococcus aureus Infections; Ventilator Associated Alpha Toxin; hly Pneumonia (VAP) Tabalumab Tumor Necrosis Factor Ligand Superfamily Relapsing Remitting Multiple Sclerosis (RRMS); End-Stage Member 13B; B Lymphocyte Stimulator; Kidney Disease (End-Stage Renal Disease; ESRD); Rheumatoid Dendritic Cell Derived TNF Like Molecule; TNF Arthritis; Systemic Lupus Erythematosus; Multiple Myeloma and APOL Related Leukocyte Expressed Ligand (Kahler Disease) Refractory Multiple Myeloma; Relapsed 1; CD257; TNFSF13B Multiple Myeloma Tacatuzumab, Alpha Fetoprotein Receptor; AFPR Liver Cancer Tacatuzumab tetraxetan Tadocizumab Integrin Alpha 2b; GPalpha IIb; Platelet Coronary Thrombosis; Cerebral Infarction (Brain Infarction) Membrane Glycoprotein IIb; CD41; ITGA2B Antagonist Talizumab Immunoglobulin E; IgE Peanut Allergy; allergy Tamtuvetmab Canis familiaris T cell Infectious Disease; Oncology Tanezumab Beta Nerve Growth Factor; Beta NGF; NGF Chronic Pancreatitis Pain; Chronic Visceral Pain; Diabetic Neuropathic Pain; Neuropathic Pain; Cancer Pain; Chronic Pain; Low Back Pain; Osteoarthritis Pain; Interstitial Cystitis (Painful Bladder Syndrome) Tarextumab Neurogenic Locus Notch Homolog Protein 2; Small-Cell Lung Cancer; Solid Tumor; Metastatic Pancreatic NOTCH2; Neurogenic Locus Notch Homolog Cancer Protein 3; NOTCH3 Tavolixizumab Tumor Necrosis Factor Receptor Superfamily Solid Tumor; Head and Neck Cancer Squamous Cell Carcinoma Member 4; ACT35 Antigen; TAX Transcriptionally Activated Glycoprotein I Receptor; OX40L Receptor; CD134; TNFRSF4 Tefibazumab Clumping Factor A; Fibrinogen Receptor A; Staphylococcus aureus Infections Fibrinogen Binding Protein A; clfA Telisotuzumab, Hepatocyte Growth Factor Receptor; Proto Solid Tumor Telisotuzuab Oncogene c Met; Tyrosine Protein Kinase Met; vedotin HGF/SF Receptor; Scatter Factor Receptor; MET; EC 2.7.10.1 Tenatumomab Tenascin; Cytotactin; GMEM; GP 150-225; Breast Cancer; Lung Cancer; Ovarian Cancer; Colorectal Glioma Associated Extracellular Matrix Cancer; B-Cell Non-Hodgkin Lymphoma; T-Cell Lymphomas Antigen; Hexabrachion; JI; Myotendinous Antigen; Neuronectin; Tenascin C; TNC Teneliximab Tumor Necrosis Factor Receptor Superfamily Kidney Transplant Rejection; Transplant Rejection Member 5; B Cell Surface Antigen CD40; Bp50; CDw40; CD40L Receptor; TNFRSF5; CD40 Teplizumab T Cell Surface Glycoprotein CD3 Epsilon Psoriasis Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Chain; CD3E Teprotumumab Insulin Like Growth Factor 1 Receptor; CD221; Graves' Ophthalmopathy; Diabetic Macular Edema; Solid IGF1R; EC 2.7.10.1 Tumor; Breast Cancer; Ewing Sarcoma; Non-Small Cell Lung Cancer; Osteosarcoma; Rhabdomyosarcoma; Sarcomas; Synovial Sarcoma; Tesidolumab Complement C5; C3 and PZP Like Alpha 2 Thrombotic Microangiopathy Paroxysmal Nocturnal Macroglobulin Domain Containing Protein 4; Hemoglobinuria Dry (Atrophic) Macular Degeneration; C5 Intermediate Uveitis; Posterior Uveitis; Uveitis End-Stage Kidney Disease (End-Stage Renal Disease; ESRD) Wet (Neovascular/Exudative) Macular Degeneration Tezepelumab Thymic Stromal Lymphopoietin; TSLP Atopic Dermatitis; Cat Allergy; Allergic Asthma ThioMAb- CD79 chMA79b ThioMAb- CD79 huMA79b.v17 ThioMAb- CD79 huMA79b.v18 ThioMAb- CD79 huMA79b.v28 Tigatuzumab, Tumor Necrosis Factor Receptor Superfamily Adenocarcinoma; Brenner Tumor; Carcinomas; Lymphoma; Igatuzuab Member 5; B Cell Surface Antigen CD40; Metastatic Breast Cancer; Metastatic Colorectal Cancer; Bp50; CDw40; CD40L Receptor; TNFRSF5; Metastatic Ovarian Cancer; Metastatic Pancreatic Cancer; CD40; TRAIL-R2 Non-Small Cell Lung Cancer; Transitional Cell Carcinoma (Urothelial Cell Carcinoma); Hepatocellular Carcinoma Tildrakizumab Interleukin 23 Subunit Alpha; Interleukin 23 Ankylosing Spondylitis (Bekhterev's Disease); Axial Subunit p19; IL23A Spondyloarthritis; Psoriatic Arthritis; Plaque Psoriasis (Psoriasis Vulgaris) Timigutuzumab ERBB2; epidermal growth factor receptor 2; Breast Cancer; Adenocarcinoma Of The Gastroesophageal receptor tyrosine-protein kinase Junction; Gastric Cancer; Metastatic Breast Cancer Timolumab Membrane Primary Amine Oxidase; Copper Primary Sclerosing Cholangitis; Neurology; Plaque Psoriasis Amine Oxidase; Semicarbazide-Sensitive (Psoriasis Vulgaris); Rheumatoid Arthritis; Chronic Amine Oxidase; Vascular Adhesion Protein 1; Obstructive Pulmonary Disease (COPD); Inflammatory Bowel HPA0; A0C3; EC 1.4.3.21 Disease; Psoriasis; Rheumatoid Arthritis Tisotumab Tissue Factor; TF Ovarian Cancer; Non-Small Cell Lung Cancer; Esophageal vedotin Cancer; Cervical Cancer; Bladder Cancer; Endometrial Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Pancreatic Cancer; Cancer Tocilizumab Interleukin 6 Receptor; IL6R Systemic Sclerosis (Scleroderma); Amyotrophic Lateral Sclerosis; Dermatomyositis; Polymyositis; Pulmonary Arterial Hypertension; Schnitzler Syndrome; B-Cell Chronic Lymphocytic Leukemia; Polymyalgia Rheumatica; Giant Lymph Node Hyperplasia (Castleman's Disease); Ankylosing Spondylitis (Bekhterev's Disease); Metastatic Pancreatic Cancer; Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis (PJIA); Systemic Idiopathic Juvenile Arthritis; Giant Lymph Node Hyperplasia (Castleman's Disease); Rheumatoid Arthritis; Rheumatoid Arthritis; Takayasu Arteritis; Vasculitis” Tomuzotuximab Epidermal Growth Factor Receptor; Proto Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Oncogene c ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Non-Small Cell Lung Cancer; Solid Tumor Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Toralizumab CD40 Ligand; T Cell Antigen Gp39; TNF Related Multiple Sclerosis; Crohn's Disease (Regional Enteritis); Activation Protein; Tumor Necrosis Factor Idiopathic Thrombocytopenic Purpura (Immune Ligand Superfamily Member 5; CD154; CD40LG Thrombocytopenic Purpura); Autoimmune Disorders; Psoriasis; Systemic Lupus Erythematosus Tosatoxumab Staphylococcus aureus Alpha Hemolysin; Community Acquired Pneumonia; Hospital Acquired Pneumonia Alpha Toxin; hly (HAP); Sepsis; Ventilator Associated Pneumonia (VAP) Tositumomab B Lymphocyte Antigen CD20; B Lymphocyte B-Cell Non-Hodgkin Lymphoma; Follicular Lymphoma Surface Antigen B1; Bp35; Leukocyte Surface Antigen Leu 16; Membrane Spanning 4 Domains Subfamily A Member 1; CD20; MS4A1 Tovetumab Platelet Derived Growth Factor Receptor Solid Tumor; Hepatocellular Carcinoma; Advanced Malignancy; Alpha; Alpha Type Platelet Derived Growth Glioblastoma Multiforme (GBM); Non-Small Cell Lung Cancer; Factor Receptor; CD140 Antigen Like Family Member A; Platelet Derived Growth Factor Receptor 2; CD140a; PDGFRA; EC 2.7.10.1 Antagonist Tralokinumab Interleukin 13; IL13 Ulcerative Colitis; Idiopathic Pulmonary Fibrosis; Atopic Dermatitis; Asthma Trastuzumab, Receptor Tyrosine Protein Kinase ERBB 2; Gastric Cancer; Metastatic Breast Cancer; Metastatic Trastuzumab Metastatic Lymph Node Gene 19 Protein; Proto Transitional (Urothelial) Tract Cancer; Pancreatic Cancer; duocarmazine, Oncogene Neu; Proto Oncogene C ErbB 2; Adenocarcinoma Of The Gastroesophageal Junction; Breast Trastuzumab Tyrosine Kinase Type Cell Surface Receptor Cancer; Gastric Cancer; Cancer emtansine, HER2; p185erbB2; HER2; CD340; ERBB2; rhuMab HER2, HER2/neu; EC 2.7.10.1 rhuMab HER2(9C1), Herceptin, TRC-105, TRC105 Endoglin; CD105; ENG Breast Cancer; Non-Small Cell Lung Cancer; Fallopian Tube Cancer; Epithelial Ovarian Cancer; Colorectal Cancer; Bladder Cancer; Metastatic Breast Cancer; Angiosarcoma; Choriocarcinoma (Gestational Trophoblastic Neoplasia); Hepatocellular Carcinoma; Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Metastatic Renal Cell Carcinoma; Myocardial Fibrosis; Peritoneal Cancer; Recurrent Glioblastoma Multiforme (GBM); Transitional Cell Carcinoma (Urothelial Cell Carcinoma); Wet (Neovascular/ Exudative) Macular Degeneration Tregalizumab T Cell Surface Glycoprotein CD4; T Cell Multiple Sclerosis; Plaque Psoriasis (Psoriasis Vulgaris); Surface Antigen T4/Leu 3; CD4 Activator Rheumatoid Arthritis Tremelimumab, Cytotoxic T Lymphocyte Protein 4; Cytotoxic T Non-Small Cell Lung Cancer; Adenocarcinoma Of The Ticiliuab, Lymphocyte Associated Antigen 4; CD152; Gastroesophageal Junction; Epithelial Ovarian Cancer; Ticilimumab CTLA4; CTLA-4 Fallopian Tube Cancer; Gastric Cancer; Hepatocellular Carcinoma; Metastatic Breast Cancer; Peritoneal Cancer; Human Immunodeficiency Virus (HIV) Infections (AIDS); Bladder Cancer; Colorectal Cancer; Gastrointestinal Tract Cancer; Prostate Cancer; Renal Cell Carcinoma; Malignant Pleural Mesothelioma; Metastatic Melanoma; Metastatic Pancreatic Cancer Trevogrumab Growth/Differentiation Factor 8; Myostatin; Sarcopenia GDF8; MSTN Tucotuzumab, Epithelial Cell Adhesion Molecule; Ovarian Cancer; Prostate Cancer; Renal Cell Carcinoma; Non- Tucotuzumab Adenocarcinoma Associated Antigen; Cell Small Cell Lung Cancer; Colorectal Cancer; Small-Cell Lung celmoleukin Surface Glycoprotein Trop 1; Epithelial Cell Cancer; Cancer Surface Antigen; Epithelial Glycoprotein 314; KS ¼ Antigen; KSA; Tumor Associated Calcium Signal Transducer 1; CD326; EPCAM; EpCAM Tuvirumab Hepatitis B Virus Surface Antigen; HBsAg Hepatitis B Ublituximab B Lymphocyte Antigen CD20; B Lymphocyte Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Surface Antigen B1; Bp35; Leukocyte Surface Lymphocytic Leukemia (CLL); B-Cell Non-Hodgkin Lymphoma; Antigen Leu 16; Membrane Spanning 4 Mantle Cell Lymphoma; Neuromyelitis Optica (Doves Domains Subfamily A Member 1; CD20; MS4A1 Syndrome); Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL) Ulocuplumab C—X—C Chemokine Receptor Type 4; FB22; Acute Myelocytic Leukemia (AML; Acute Myeloblestic Fusin; HM89; LCR1; Leukocyte Derived Seven Leukemia); Refractory Multiple Myeloma; Relapsed Multiple Transmembrane Domain Receptor; Myeloma; Diffuse Large B-Cell Lymphoma; Follicular Lipopolysaccharide Associated Protein 3; Lymphoma; Metastatic Pancreatic Cancer; Refractory Acute Stromal Cell Derived Factor 1 Receptor; Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia NPYRL; CD184; CXCR4 (CLL); Relapsed Acute Myeloid Leukemia; Relapsed Chronic Lymphocytic Leukemia (CLL); Small-Cell Lung Cancer Urelumab Tumor Necrosis Factor Receptor Superfamily Diffuse Large B-Cell Lymphoma; Head and Neck Cancer Member 9; 4-IBB Ligand Receptor; T Cell Squamous Cell Carcinoma; Metastatic Melanoma; Non-Small Antigen 4-IBB Humolog; T Cell Antigen ILA; Cell Lung Cancer; Follicular Lymphoma; Gliosarcoma; CD137; TNFRSF9 Metastatic Colorectal Cancer; Recurrent Glioblastoma Multiforme (GBM); Chronic Lymphocytic Leukemia (CLL); Lymphoma; Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed Chronic Lymphocytic Leukemia (CLL) Urtoxazumab Shiga Toxin Type 2; stx2 Escherichia coli Infections Ustekinumab Interleukin 12 Subunit Beta; Cytotoxic Ulcerative Colitis; Axial Spondyloarthritis; Systemic Lupus Lymphocyte Maturation Factor 40 kDa Erythematosus; Type I Diabetes (Juvenile Diabetes); Crohn's Subunit; CLMF p40; IL12 Subunit p40 NK Cell Disease (Regional Enteritis); Relapsing Remitting Multiple Stimulatory Factor Chain 2; IL12B Sclerosis (RRMS); Hidradenitis Suppurativa; Plaque Psoriasis (Psoriasis Vulgaris); Psoriasis; Rheumatoid Arthritis; Primary Biliary Cirrhosis; Atopic Dermatitis; Sarcoidosis; Psoriatic Arthritis; Plaque Psoriasis (Psoriasis Vulgaris); Crohn's Disease (Regional Enteritis)” utomilumab Tumor Necrosis Factor Receptor Superfamily Anaplastic Thyroid Cancer; Bladder Cancer; Cervical Cancer; Member 9; 4-IBB Ligand Receptor; T Cell Diffuse Large B-Cell Lymphoma; Follicular Lymphoma; Gastric Antigen 4-IBB Humping; T Cell Antigen ILA; Cancer; Metastatic Hepatocellular Carcinoma (HCC); Ovarian CD137; TNFRSF9 Cancer; Pancreatic Cancer; Renal Cell Carcinoma; Sarcomas; Thymoma (Thymic Epithelial Tumor); Colorectal Cancer; Head and Neck Cancer Squamous Cell Carcinoma; Metastatic Breast Cancer; Metastatic Melanoma; Non-Small Cell Lung Cancer; Small-Cell Lung Cancer Vadastuximab, Myeloid Cell Surface Antigen CD33; Sialic Acid Acute Myelocytic Leukemia (AML; Acute Myeloblestic Vadastuximab Binding Ig Like Lectin 3; gp67; CD33 Leukemia); Myelodysplastic Syndrome; Refractory Acute talirine Myeloid Leukemia; Relapsed Acute Myeloid Leukemia Vandortuzumab, Metalloreductase STEAP1; Six Transmembrane Metastatic Hormone Refractory (Castration Resistant; Vandortuzumab Epithelial Antigen Of The Prostate 1; STEAP1; androgen-Independent) Prostate Cancer vedotin EC 1.16.1. Vantictumab Frizzled 7; hFz7; FzE3; FZD7 Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Pancreatic Ductal Adenocarcinoma Vanucizumab Angiopoietin 2; Ang 2; ANGPT2; Vascular Metastatic Colorectal Cancer; Epithelial Ovarian Cancer; Endothelial Growth Factor A; Vascular Fallopian Tube Cancer; Peritoneal Cancer; Solid Tumor Permeability Factor; VEGFA Vapaliximab Membrane Primary Amine Oxidase; Copper Inflammation Amine Oxidase; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; HPAD; ADC3; EC 1.4.3.21 Varisacumab, Vascular Endothelial Growth Factor A; Metastatic Cancer; Oncology Apagin Vascular Permeability Factor; VEGFA Varlilumab CD27 Antigen; CD27L Receptor; T Cell Bladder Cancer; Breast Cancer; Colorectal Cancer; Fallopian Activation Antigen CD27; Tumor Necrosis Tube Cancer; Glioblastoma Multiforme (GBM); Head and Neck Factor Receptor Superfamily Member 7; T14; Cancer Squamous Cell Carcinoma; Metastatic Melanoma; Non- TNFRSF7; CD27 Small Cell Lung Cancer; Ovarian Cancer; Renal Cell Carcinoma; Colorectal Cancer; Hormone Refractory (Castration Resistant; androgen-Independent) Prostate Cancer; Leukemias; Lymphoma; Metastatic Melanoma; Non-Small Cell Lung Cancer; Ovarian Cancer; Renal Cell Carcinoma Vatelizumab Integrin Alpha 2; CD49 Antigen Like Family Crohn's Disease (Regional Enteritis); Ulcerative Colitis; Member B; Collagen Receptor; Platelet Relapsing Remitting Multiple Sclerosis (RRMS) Membrane Glycoprotein 1a; VLA 2 Subunit Alpha; CD49b; ITGA2 Vedolizumab Integrin Alpha 4; CD49 Antigen Like Family Primary Sclerosing Cholangitis; Celiac Disease; Graft Versus Member D; VLA4 Subunit Alpha; CD49d; ITGA4; Host Disease (GVHD); Human Immunodeficiency Virus (HIV) Integrin Beta 7; Gut Homing Receptor Beta Infections (AIDS); Melanoma; Crohn's Disease (Regional Subunit; ITGB7 Enteritis); Ulcerative Colitis” Veltuzumab B Lymphocyte Antigen CD20; B Lymphocyte Idiopathic Thrombocytopenic Purpura (Immune Surface Antigen B1; Bp35; Leukocyte Surface Thrombocytopenic Purpura); Non-Hodgkin Lymphoma; Antigen Leu 16; Membrane Spanning 4 Pemphigus Vulgaris; Acute Lymphocytic Leukemia (ALL; Acute Domains Subfamily A Member 1; CD20; MS4A1 Lymphoblastic Leukemia); Chronic Lymphocytic Leukemia (CLL); Follicular Lymphoma; Systemic Lupus Erythematosus; Rheumatoid Arthritis Vepalimomab Membrane Primary Amine Oxidase; Copper Contact Dermatitis; Ulcerative Colitis; Psoriasis Amine Oxidase; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; HPAD; ADC3; EC 1.4.3.21 Vesencumab Neuropilin 1; Vascular Endothelial Cell Growth Solid Tumor Factor 165 Receptor; CD304; NRP1 Visilizumab T Cell Surface Glycoprotein CD3 Epsilon Graft Versus Host Disease (GVHD); Crohn's Disease (Regional Chain; T Cell Surface Antigen T3/Leu 4 Epsilon Enteritis); Ulcerative Colitis Chain; CD3E Vobarilizumab Interleukin 6 Receptor; IL6R Rheumatoid Arthritis; Systemic Lupus Erythematosus Volociximab Integrin Alpha 5; CD49 Antigen Like Family Age Related Macular Degeneration; Metastatic Melanoma; Member E; Fibronectin Receptor Subunit Metastatic Pancreatic Cancer; Non-Small Cell Lung Cancer; Alpha; lntegrin Alpha F; VLA 5; CD49e; ITGA5; Ovarian Cancer; Peritoneal Tumor; Renal Cell Carcinoma Integrin Beta 1; Fibronectin Receptor Subunit Beta; Glycoprotein lia; VLA 4 Subunit Beta; CD29; ITGB1 Vorsetuzumab, CD70 Antigen; CD27 Ligand; Tumor Necrosis Autoimmune Disorders; Cancer Vorsetuzumab Factor Ligand Superfamily Member 7; CD70 mafodotin Vunakizumab Interleukin 17A; Cytotoxic T Lymphocyte Psoriasis Associated Antigen B; CTLA8; IL17A Xentuzumab Insulin Like Growth Factor I; Mechano Growth Non-Small Cell Lung Cancer; Metastatic Breast Cancer; Solid Factor; Somatomedin C; IGF1; Insulin Like Tumor; Metastatic Hormone Refractory (Castration Resistant, Growth Factor II; Somatomedin A; T3M II androgen-Independent) Prostate Cancer Derived Growth Factor; IGF2 Zalutumumab Epidermal Growth Factor Receptor; Proto Non-Small Cell Lung Cancer; Squamous Cell Carcinoma; Oncogene c ErbB 1; Receptor Tyrosine Protein Colorectal Cancer; Head and Neck Cancer; Metastatic Cancer Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Zanolimumab T Cell Surface Glycoprotein CD4; T Cell Psoriasis; Rheumatoid Arthritis; Cutaneous T-Cell Lymphoma; Surface Antigen T4/Leu 3; CD4 Sezary Syndrome; Mycosis Fungoides; T-Cell Lymphomas Zatuximab Epidermal Growth Factor Receptor; Proto Glioblastoma Multiforme (GBM); Metastatic Colorectal Cancer; Oncogene c ErbB 1; Receptor Tyrosine Protein Recurrent Head and Neck Cancer Squamous Cell Carcinoma; Kinase erbB 1; HER1; ERBB1; EGFR; EC 2.7.10.1 Squamous Non-Small Cell Lung Cancer; Esophageal Cancer; Solid Tumor

Preferably, the RNA according to the present invention, the combination of RNA's according to the present invention, the composition according to the present invention, the vaccine according to the present invention, or the pharmaceutically active component of the kit according to the present invention is administered by injection, preferably by needle-less injection, more preferably by jet injection.

It is also preferred that the treatment of the diseases/disorders as described above (therapy or prophylaxis) by using the RNA according to the present invention, the combination of RNA's according to the present invention,the composition according to the present invention, the vaccine according to the present invention, or the kit according to the present invention comprises the administration of a further pharmaceutical compound. Such a further pharmaceutical compound is preferably a chemotherapeutic agent or a kinase inhibitor, in particular in the context of treatment of cancer. Moreover, in particular in the context of cancer treatment, the the treatment or prophylaxis as described herein may preferably further comprise radiation therapy.

It is also preferred that the treatment of the diseases/disorders as described above (therapy or prophylaxis) by using the RNA according to the present invention, the combination of RNA's according to the present invention, the composition according to the present invention, the vaccine according to the present invention, or the kit according to the present invention further comprises the administration of at least one modulator of an inhibitory and/or a stimulatory checkpoint molecule, such as an inhibitor of an inhibitory checkpoint molecule, preferably an inhibitor of CTLA-4 or of the PD-1 pathway.

The present invention also provides methods of treating or preventing the diseases and/or disorders as described above by administering to a subject in need thereof a (pharmaceutically) effective amount of the RNA, the combination of RNA's, the pharmaceutical composition or the vaccine according to the invention. Such a method typically comprises an optional first step of preparing the RNA, the combination of RNA's, the composition or the vaccine of the present invention, and a second step, comprising administering (a pharmaceutically effective amount of) said composition or vaccine to a patient/subject in need thereof. A subject in need thereof will preferably be a mammal. In the context of the present invention, the mammal is preferably selected from the group comprising, without being limited thereto, e.g. goat, cattle, swine, dog, cat, donkey, monkey, ape, a rodent such as a mouse, hamster, rabbit and, particularly, human, wherein the mammal typically suffers from the diseases and/or disorders as described above. Preferably, the disease/disorder is a cancer, a cardiovascular disease, an infectious disease, an autoimmune disease, a virus disease or a monogenetic disease.

In such a method according to the present invention also a combination of RNA's as described herein may be used, whereby the at least two RNA's of such a combination may be administered separately or in the same composition as described above. For example, in separate administration the at least two distinct RNA's may be administered at about the same time or consecutively via the same or different routes of administration as decribed above.

The subject receiving the RNA, the combination of RNA's, the pharmaceutical composition or the vaccine according to the invention may, for example, be a patient with cancer, preferably as defined herein, or a related condition, receiving chemotherapy (e.g. first-line or second-line chemotherapy), radiotherapy, chemoradiation (combination of chemotherapy and radiotherapy), tyrosine kinase inhibitors (e.g. EGFR tyrosine kinase inhibitors), antibody therapy and/or inhibitory and/or stimulatory checkpoint molecules (e.g. CTLA4 inhibitors, PD1 pathway inhibitors), or a patient, who has achieved partial response or stable disease after having received one or more of the treatments specified above. Support of the treatment or prophylaxis of cancer may be also envisaged in any of the other embodiments defined herein. Accordingly, any use of the RNA, the (pharmaceutical) composition or the vaccine according to the invention in co-therapy with any other approach, preferably one or more of the above therapeutic approaches, in particular in combination with surgery, radiation therapy, chemotherapy, chemoradiation, and/or treatment with kinase inhibitors, modulators of inhibitory and/or stimulatory checkpoint molecules or antibodies is within the scope of the present invention. In particular, modulators of inhibitory and/or stimulatory checkpoint molecules used for combination with the RNA, the vaccine or the (pharmaceutical) composition according to the invention may be encoded by a nucleic acid, preferably an RNA and most preferably by an mRNA.

For administration, preferably any of the administration routes may be used as defined herein. In particular, an administration route is used, which is suitable for treating or preventing any of the disorders and/or diseases as described herein. Administration of the composition and/or the vaccine according to the invention may then occur prior, concurrent and/or subsequent to administering another composition and/or vaccine as defined herein, which may—in addition—contain another RNA or combination of RNAs encoding different fragments of the same antibody or different antibodies, wherein each antibody encoded by the RNA according to the invention is preferably suitable for the treatment or prophylaxis of any of the disorders and/or diseases as described herein. In this context, a treatment as defined herein may also comprise the modulation of a disease associated to the of the disorders and/or diseases as described herein.

According to a preferred embodiment of this aspect of the invention, the (pharmaceutical) composition or the vaccine according to the invention is administered by injection. Any suitable injection technique known in the art may be employed. Preferably, the inventive composition is administered by injection, preferably by needle-less injection, for example by jet-injection.

In one embodiment, the inventive composition comprises at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more RNAs as defined herein, each of which is preferably injected separately, preferably by needle-less injection. Alternatively, the inventive composition comprises at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more RNAs, wherein the at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more RNAs are administered, preferably by injection as defined herein, as a mixture.

The (passive) immunization protocol for the immunization of a subject typically comprises a series of single doses or dosages of the (pharmaceutical) composition or the vaccine according to the invention. A single dosage, as used herein, refers to the initial/first dose, a second dose or any further doses, respectively. In this context, each single dosage preferably comprises the administration of RNA encoding the same antibody or the same combination of antibodies as defined herein, wherein the interval between the administration of two single dosages can vary from at least one day, preferably 2, 3, 4, 5, 6 or 7 days, to at least one week, preferably 2, 3, 4, 5, 6, 7 or 8 weeks. The intervals between single dosages may be constant or vary over the course of the immunization protocol, e.g. the intervals may be shorter in the beginning and longer towards the end of the protocol. Depending on the total number of single dosages and the interval between single dosages, the immunization protocol may extend over a period of time, which preferably lasts at least one week, more preferably several weeks (e.g. 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 weeks), even more preferably several months (e.g. 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 18 or 24 months). Each single dosage preferably encompasses the administration of an RNA encoding an antibody, preferably of a combination of at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more antibodies as defined herein and may involve at least one, preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 injections. In some cases, the composition or the vaccine according to the invention is administered as a single dosage typically in one injection. In the case, where the vaccine according to the invention comprises separate RNA formulations encoding distinct antibody fragments or distinct antibodies as defined herein, the minimum number of injections carried out during the administration of a single dosage may correspond to the number of separate components of the vaccine. In certain embodiments, the administration of a single dosage may encompass more than one injection for each component of the vaccine (e.g. a specific RNA formulation comprising an RNA encoding, for instance, one antibody as defined herein). For example, parts of the total volume of an individual component of the vaccine may be injected into different body parts, thus involving more than one injection. In a more specific example, a single dosage of a vaccine comprising four separate RNA formulations, each of which is administered in two different body parts, comprises eight injections. Typically, a single dosage comprises all injections required to administer all components of the vaccine, wherein a single component may be involve more than one injection as outlined above. In the case, where the administration of a single dosage of the vaccine according to the invention encompasses more than one injection, the injection are carried out essentially simultaneously or concurrently, i.e. typically in a time-staggered fashion within the time-frame that is required for the practitioner to carry out the single injection steps, one after the other. The administration of a single dosage therefore preferably extends over a time period of several minutes, e.g. 2, 3, 4, 5, 10, 15, 30 or 60 minutes.

Administration of the RNA as defined herein, the (pharmaceutical) composition or the vaccine according to the invention may be carried out in a time staggered treatment. A time staggered treatment may be e.g. administration of the RNA, the composition or the vaccine prior, concurrent and/or subsequent to a conventional therapy of any of of the disorders and/or diseases as described herein, e.g. by administration of the RNA, the composition or the vaccine prior, concurrent and/or subsequent to a therapy or an administration of a therapeutic suitable for the treatment or prophylaxis of any of of the disorders and/or diseases as described herein. Such time staggered treatment may be carried out using e.g. a kit, preferably a kit of parts as defined herein.

Time staggered treatment may additionally or alternatively also comprise an administration of the RNA as defined herein, the (pharmaceutical) composition or the vaccine according to the invention in a form, wherein the RNA encoding an antibody as defined herein or a fragment or variant thereof, preferably forming part of the composition or the vaccine, is administered parallel, prior or subsequent to another RNA encoding an antibody as defined above, preferably forming part of the same inventive composition or vaccine. Preferably, the administration (of all RNAs) occurs within an hour, more preferably within 30 minutes, even more preferably within 15, 10, 5, 4, 3, or 2 minutes or even within 1 minute. Such time staggered treatment may be carried out using e.g. a kit, preferably a kit of parts as defined herein.

In a preferred embodiment, the pharmaceutical composition or the vaccine of the present invention is administered repeatedly, wherein each administration preferably comprises individual administration of the at least one mRNA of the inventive composition or vaccine. At each time point of administration, the at least one mRNA may be administered more than once (e.g. 2 or 3 times). In a particularly preferred embodiment of the invention, at least two, three, four, five, six or more RNAs (each encoding a distinct one of the antibodies as defined herein) are administered at each time point, wherein each RNA is administered twice by injection, distributed over the four limbs.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 illustrates the structure of an IgG antibody. IgG antibodies are built up from in each case two identical light and two heavy protein chains which are bonded to one another via disulfide bridges. The light chain comprises the N-terminal variable domain V_(L) and the C-terminal constant domain C_(L). The heavy chain of an IgG antibody can be divided into an N-terminal variable domain V_(H) and three constant domains C_(H)1, C_(H)2 and C_(H)3.

FIG. 2 shows the gene cluster for the light and the heavy chains of an antibody:

-   -   (A): Gene cluster for the light chain κ.     -   (B): Gene cluster for the light chain λ.     -   (C): and (D): Gene cluster for the heavy chain.     -   In this context, the variable region of a heavy chain is         composed of three different gene segments. In addition to the V         and J segments, additional D segments are also found here. The         V_(H), D_(H) and J_(H) segments can likewise be combined with         one another virtually as desired to form the variable region of         the heavy chain.

FIG. 3 illustrates in the form of a diagram the differences in the light and heavy chains of murine (i.e. obtained in the mouse host organism), chimeric, humanized and human antibodies.

FIG. 4 shows an overview of the structure of various antibody fragments. The constituents of the antibody fragments are shown on a dark grey background.

FIG. 5 shows various variants of antibodies and antibody fragments in FIGS. 5A, 5B and 5C:

-   -   (A) shows a diagram of an IgG antibody of two light and two         heavy chains.     -   (B) shows an Fab fragments from the variable and a constant         domain in each case of a light and a heavy chain. The two chains         are bonded to one another via a disulfide bridge.     -   (C) shows an scFv fragment from the variable domain of the light         and the heavy chain, which are bonded to one another via an         artificial polypeptide linker.

FIG. 6 shows a presentation of an exemplified antibody-coding (modified) RNA according to

-   -   the invention as an expression construct. In this:     -   V_(H)=variable domain of the heavy chain;     -   C_(H)=constant domain of the heavy chain;     -   V_(L)=variable domain of the light chain;     -   C_(L)=constant domain of the light chain;     -   SIRES=internal ribosomal entry site (IRES, superlRES)     -   muag=mutated form of the 3′ UTR of the alpha-globin gene; and     -   A70C30=polyA-polyC tail.

FIG. 7 shows a diagram of the detection of an antibody coded by an RNA according to the invention by means of ELISA on the example of the antigen Her2.

FIG. 8 shows the wild-type DNA sequence of the heavy chain of the antibody rituximab (=Rituxan, MabThera) (wild-type: GC content: 56.5%, length: 1,344) (SEQ ID NO: 61161).

FIG. 9 shows a GC-optimized DNA sequence of the heavy chain of the antibody rituximab (=Rituxan, MabThera) (GC content: 65.9%, length: 1,344) (SEQ ID NO: 61162).

FIG. 10 shows the wild-type DNA sequence of the light chain of the antibody rituximab (=Rituxan, MabThera) (wild-type: GC content: 58.5%, length: 633) (SEQ ID NO: 61163).

FIG. 11 shows a GC-optimized DNA sequence of the light chain of the antibody rituximab (=Rituxan, MabThera) (GC content: 67.2%, length: 633) (SEQ ID NO: 61164).

FIG. 12 shows the total construct of a GC-optimized DNA sequence of the antibody rituximab (=Rituxan, MabThera) with the light and heavy chains (SEQ ID NO: 61165). The total construct contains the following sequences and cleavage sites (see also alternative cleavage sites of FIG. 25, SEQ ID NO: 61209):

AAGCTT HindIII

CATCATCATCATCATCAT His tag Signal peptide, HLA-A*0201: GC-rich ATGGCCGTGATGGCGCCGCGGACCCTGGTCCTCCTGCTGAGCGG CGCCCTCGCCCTGACGCAGACCTGGGCCGGG.

The coding region of the heavy chain sequence starts with the signal peptide as given above (italic). This region is G/C enriched as well. The subsequent sequence starting with CAG represents the actual antibody coding sequence (see FIG. 9) for the heavy chain, which ends with AAG and is followed by the above described His tag sequence. Finally, the open reading frame for the heavy chain ends with the stop codon TGA (

). The coding region for the light chain sequence starts 3′ upstream with the signal peptide's ATG as given above followed by the light chain's coding region for the light chain starting with CAG running to the stop codon TGA (

) (see FIG. 11). Both coding regions for the light and the heavy chain are separated by an IRES element (

) The inventive RNA coded by the construct given in FIG. 12 may or may not contain a (His) tag sequence and may contain a signal peptide sequence different from the above peptide sequence or may even have no signal peptide sequence. Accordingly, the inventive RNA molecule contains preferably the coding region (with or without a signal peptide sequence at its beginning) of the heavy and/or the light chain (e.g. as shown in FIG. 12), preferably in combination with at least one ribosomal entry site.

FIG. 13 shows the wild-type DNA sequence of the heavy chain of the antibody cetuximab (=Erbitux) (wild-type: GC content: 56.8%, length: 1,359) (SEQ ID NO: 61166).

FIG. 14 shows a GC-optimized DNA sequence of the heavy chain of the antibody cetuximab (=Erbitux) (GC content: 65.9%, length: 1,359) (SEQ ID NO: 61167).

FIG. 15 shows the wild-type DNA sequence of the light chain of the antibody cetuximab (=Erbitux) (wild-type: GC content: 58.2%, length: 642) (SEQ ID NO: 61168).

FIG. 16 shows a GC-optimized DNA sequence of the light chain of the antibody cetuximab (=Erbitux) (GC content: 65.7%, length: 642) (SEQ ID NO: 61169).

FIG. 17 shows the total construct of a GC-optimized DNA sequence of the antibody cetuximab (=Erbitux) with the light and heavy chains (SEQ ID NO: 61170). The total construct contains the following sequences and cleavage sites (see also alternative cleavage sites of FIG. 26, SEQ ID No 61210):

AAGCTT HindIII

CATCATCATCATCATCAT His tag Signal peptide, HLA-A*0201: GC-rich ATGGCCGTGATGGCGCCGCGGACCCTGGTCCTCCTGCTGAGCGG CGCCCTCGCCCTGACGCAGACCTGGGCCGGG.

The coding region of the heavy chain sequence starts with the signal peptide as given above (italic). This region is G/C enriched as well. The subsequent sequence starting with CAG represents the actual antibody coding sequence (see FIG. 14) for the heavy chain, which ends with AAG and is followed by the above described His tag sequence. Finally, the open reading frame for the heavy chain ends with the stop codon TGA (

). The coding region for the light chain sequence starts 3′ upstream with the signal peptide's ATG as given above followed by the light chain's coding region for the light chain starting with GAC running to the stop codon TGA (

) (see FIG. 16). Both coding regions for the light and the heavy chain are separated by an IRES element (

). The inventive RNA coded by the construct given in FIG. 17 may or may not contain a (His) tag sequence and may contain a signal peptide sequence different from the above peptide sequence or may even have no signal peptide sequence. Accordingly, the inventive RNA molecule contains preferably the coding region (with or without a signal peptide sequence at its beginning) of the heavy and/or the light chain (e.g. as shown in FIG. 17), preferably in combination with at least one ribosomal entry site.

FIG. 18 shows the wild-type DNA sequence of the heavy chain of the antibody trastuzumab (=Herceptin) (wild-type: GC content: 57.8%, length: 1,356) (SEQ ID NO: 61171).

FIG. 19 shows a GC-optimized DNA sequence of the heavy chain of the antibody trastuzumab (=Herceptin) (GC content: 67.0%, length: 1,356) (SEQ ID NO: 61172).

FIG. 20 shows the wild-type DNA sequence of the light chain of the antibody trastuzumab (=Herceptin) (wild-type: GC content: 56.9%, length: 645) (SEQ ID NO: 61173).

FIG. 21 shows a GC-optimized DNA sequence of the light chain of the antibody trastuzumab (=Herceptin) (GC content: 66.4%, length: 645) (SEQ ID NO: 61174).

FIG. 22 shows a total construct of the GC-optimized DNA sequence of the antibody trastuzumab (=Herceptin) with the light and heavy chains (SEQ ID NO: 61175). The total construct contains the following sequences and cleavage sites (see also alternative cleavage sites of FIG. 27, SEQ ID NO: 61211):

AAGCTT HindIII

CATCATCATCATCATCAT His tag Signal peptide, HLA-A*0201: GC-rich ATGGCCGTGATGGCGCCGCGGACCCTGGTCCTCCTGCTGAGCGG CGCCCTCGCCCTGACGCAGACCTGGGCCGGG.

The coding region of the heavy chain sequence starts with the signal peptide as given above (italic). This region is G/C enriched as well. The subsequent sequence starting with GAG represents the actual antibody coding sequence (see FIG. 19) for the heavy chain, which ends with AAG and is followed by the above described His tag sequence. Finally, the open reading frame for the heavy chain ends with the stop codon TGA (

). The coding region for the light chain sequence starts 3′ upstream with the signal peptide's ATG as given above followed by the light chain's coding region for the light chain starting with GAC running to the stop codon TGA (

) (see FIG. 21). Both coding regions for the light and the heavy chain are separated by an IRES element (

). The inventive RNA coded by the construct given in FIG. 22 may or may not contain a (His) tag sequence and may contain a signal peptide sequence different from the above peptide sequence or may even have no signal peptide sequence. Accordingly, the inventive RNA molecule contains preferably the coding region (with or without a signal peptide sequence at its beginning) of the heavy and/or the light chain (e.g. as shown in FIG. 22), preferably in combination with at least one ribosomal entry site.

FIG. 23 shows for Example 1 RNA-mediated antibody expression in cell culture. CHO or BHK cells were transfected with 20 μg of antibody-encoding mRNA according to the invention which was produced (RNA, G/C enriched, see above) or mock-transfected. 24 hours after transfection protein synthesis was analysed by Western blotting of cell lysates. Cells harboured about 0.5 μg of protein as assessed by Western Blot analysis. Each lane represents 10% of total lysate. Humanised antibodies served as control and for a rough estimate of protein levels. The detection antibody recognises both heavy and light chains; moreover, it shows some unspecific staining with cell lysates (three distinct bands migrating much slower than those of the antibodies). A comparison with control antibodies clearly demonstrates that heavy and light chains were produced in equal amounts.

FIG. 24 shows for Example 1 that RNA-mediated antibody expression gives rise to a functional protein (antibody). Functional antibody formation was addressed by FACS staining of antigen-expressing target cells. In order to examine the production of functional antibodies, cell culture supernatants of RNA-transfected (20 μg of Ab-RNA as defined above in Example 1) cells were collected after 48 to 96 hours. About 8% of total supernatant was used to stain target cells expressing the respective antigen. Humanised antibodies served as control and for a rough estimate of protein levels. Primary antibody used for cell staining: a) humanised antibody; b) none; c,d) supernatant from RNA-transfected cells expressing the respective antibody; e) supernatant from mock-transfected CHO cells. Calculations on the basis of the analysis shown in FIG. 24 reveal that cells secreted more than 12-15 μg of functional antibody within 48-96 hours. Accordingly, the present invention proves that RNA encoding antibodies may enter into cell, may be expressed within the cell and considerable amounts of RNA encoded antibodies are then secreted by the cell into the surrounding medium/extracellular space. Cell transfection in vivo or in vitro by the inventive RNA may therefore be used to provide antibodies acting e.g. therapeutically in the extracellular space.

FIG. 25 shows an alternative sequence of the construct of FIG. 12 (antibody rituximab), wherein the restriction sites have been modified as compared to SEQ ID NO: 61165 of FIG. 12 (SEQ ID NO: 61209). For closer information with regard to the description of various sequence elements it is referred to FIG. 12.

FIG. 26 shows an alternative sequence of the construct of FIG. 17 (antibody cetuximab), wherein the restriction sites have been modified as compared to SEQ ID NO: 61170 of FIG. 17 (SEQ ID NO: 61210). For closer information with regard to the description of various sequence elements it is referred to FIG. 17.

FIG. 27 shows an alternative sequence of the construct of FIG. 22 (antibody trastuzumab), wherein the restriction sites have been modified as compared to SEQ ID NO: 61175 of FIG. 22 (SEQ ID NO: 61211). For closer information with regard to the description of various sequence elements it is referred to FIG. 22.

FIG. 28 shows for Example 2 the median survival time of mice injected with mRNA encoding the antibody trastuzumab (Herceptin) as compared to the median survival time of naïve control mice in an in vivo tumor model. Briefly, BALB/c nu/nu mice (n=14 per group) were subcutaneously implanted with slow-release estrogen pellets (0.72 mg 17β-estradiol). Mice were inoculated subcutaneously with 10×10⁶ BT-474 tumour cells (100 μl of a cell/matrigel suspension) per mouse on day 0. Treatment was started on day 11 when tumors became injectable. Mice were treated twice weekly for up to 3.5 weeks with a single dose of 50 μg of mRNA (R1965) in a 50 μl injection volume (Ringer Lactate buffer).

FIG. 29 shows for Example 3 the concentration of cetuximab in the supernatant of R3578-transfected cells (in vitro antibody expression study). Briefly, HEK293T cells were transfected with 1 μg or 4 μg of mRNA (R3578) using the Lipofectamine2000 reagent. 24 hours after the transfection, the supernatant was collected and used for staining of A431 cells (EGFR-expressing cell line) and analysed by flow cytometry (FACS). The concentration of Cetuximab in the supernatant of the transfected cells was calculated using a standard curve generated with the commercially available Cetuximab protein.

FIG. 30 shows for Example 3 the median survival time of mice injected with mRNA encoding the antibody cetuximab (Erbitux) as compared to the median survival time of naïve control mice in an in vivo tumor model. Briefly, BALB/c nu/nu mice were inoculated subcutaneously in the right flank (near the dorsal region) with a cell suspension of about 5×10⁶ SW48 cells (human colon cancer cell line; 100 μl of a cell/matrigel suspension). When the tumor reached a volume of 400-500 mm³, the tumor tissue blocks were harvested for transplantation. SW48 tumor blocks (about 1.5 mm×1.5 mm×1.5 mm in size) were subcutaneously transplanted in the right flank (near the dorsal region) of 125 animals; eventually 40 tumor-bearing mice were enrolled in the study and were assigned to one of the following four groups (n=10 per group): untreated, Ringer Lactate (“RiLa”), 50 μg mRNA encoding cetuximab (“R3578 (50 μg)”) and 100 μg mRNA encoding cetuximab (“R3578 (100 μg)”). Except for the untreated group, all mice received the respective “treatment” (RiLa or 50 or 100 μg mRNA) every 3 days for a total of seven injections (21 days).

FIG. 31 shows for Example 3 the concentration of cetuximab antibody in the sera of treated mice. Briefly, the sera from mice injected with 100 μg and 50 μg of R3578 were collected 24 hours after the third application and tested by flow cytometry (FACS) for the presence of functional antibodies as described above. The sera from untreated animals and mice injected with RiLa served as controls.

FIG. 32 shows for Example 4 the reduction of the mean tumor volume after treatment with mRNA encoding Blinatumomab (R3981) versus untreated (RiLa control buffer experiment). Mean tumor volume after treatment with R3981 or buffer is depicted. NOG mice were subcutaneously challenged with a mixture of NALM-6 cells and human PBMCs followed by treatment with R3981 or buffer as a control (5x on consecutive days). Tumor growth was measured using caliper and tumor growth curves are depicted. Contrary to the control group, only one of six mice in the cohort treated with the mRNA encoding Blinatumomab developed a measurable tumor. As a result, a statistically significant inhibition of tumor growth was observed compared to the control group.

FIG. 33 shows for Example 4 the tumor volume of R3981- and buffer-treated mice on day 34. Day 34 was chosen for this analysis as the last day when all animals in all groups were still alive and therefore the mean tumor volumes could be compared. The treatment with the mRNA encoding Blinatumomab (R3981) significantly inhibited tumor growth compared to the buffer control. The dots represent the tumor volume of individual mice and the horizontal line represents the median.

FIG. 34 shows for Example 4 the median survival time of mice injected with mRNA encoding the antibody blinatumomab (“R3981”) as compared to the median survival time of buffer control mice in an in vivo tumor model. Briefly, survival proportions after tumor challenge with NALM-6 cells were investigated. Survival in groups treated with R3981 or buffer are shown. MS: median survival time.

FIG. 35 shows for Example 5 expression of anti-BoNTx antibodies by mRNA transfected cells evaluated by Western blot analysis. Aliquots of cell lysates and supernatants were separated by SDS-PAGE, blotted onto a membrane, and stained with an anti-human detection antibody recognizing heavy as well as light chain. Samples from cells transfected with mRNA encoding an unrelated antibody were used as positive control. Mock-transfected cells served as negative control.

FIG. 36 shows for Example 6 the expression of anti-HA antibodies by mRNA transfected cells evaluated by Western blot analysis. Aliquots of cell lysates and supernatants were separated by SDS-PAGE, blotted onto a membrane, and stained with an anti-human detection antibody recognizing heavy as well as light chain. 100 ng of a recombinant antibody were used as positive control and for rough quantification of mRNA-mediated antibody expression. Mock-transfected cells served as negative control.

FIG. 37 shows for Example 6 the production of functional anti-HA antibodies by mRNA transfected cells evaluated by flow cytometry. 24 h after transfection of BHK cells with mRNA-encoded anti-HAn antibody supernatant was collected and used for staining of HA-expressing HeLa cells. The supernatant of mock-transfected cells served as negative control.

FIG. 38 shows for Example 7 the production of functional anti-RAV G antibodies by mRNA transfected cells evaluated by flow cytometry. 24 h after transfection of BHK cells with mRNA-encoded anti-RAV G antibody supernatant was collected and used for staining of RAV G-expressing HeLa cells. The supernatant of mock-transfected cells served as negative control.

FIG. 39 shows the complete mRNA sequence “R1965” coding for the antibody Trastuzumab (Herceptin) (cf. Example 1).

FIG. 40 shows the complete mRNA sequence “R3578” coding for the antibody Cetuximab

(Erbitux) (cf. Example 1).

FIG. 41 shows the complete mRNA sequence “R3981” coding for the antibody Blinatumomab (cf. Example 1).

FIG. 42 shows for Example 8 data resulting from an ELISA assay (titers of anti-HIV antibodies expressed by mRNA). Individual supernatants (triplicates; pooled) were analyzed by IgG-specific ELISA. For mock co-transfection, an mRNA encoding eGFP was used.

FIG. 43 shows for Example 8 the HIV entry in MAGI-R5 cells in a Magi R5-Tropic Antiviral Assay (VC=virus control; CC=cell control) of a control without RNA (A); the HIV entry in MAGI-R5 cells in a Magi R5-Tropic Antiviral Assay (VC=virus control; CC=cell control) of mRNA-encoded VRC01 (B); and the HIV entry in MAGI-R5 cells in a Magi R5-Tropic Antiviral Assay (VC=virus control; CC=cell control) of commercially available recombinant VRC01 control (C).

FIG. 44 shows for Example 9 the concentration of human antibodies in the supernatant of R3917-transfected HEK293T cells evaluated by ELISA. The plates were coated with anti-human antibodies, followed by incubation with the supernatant of R3917-transfected cells and anti-human detection antibodies. The concentration of human antibodies was calculated from the standard curve generated using commercially available Rituximab. The supernatant from the sham-transfected cells (WFI, water for injection) served as a control.

FIG. 45 shows for Example 9 the concentration of the functional Rituximab antibodies in the supernatant of R3917-transfected cells evaluated by flow cytometry. 24 h after the transfection of HEK293T cells with mRNA-encoded Rituximab (R3917) supernatant was collected and used for staining of CD20-expressing Raji cells. The concentration of Rituximab was calculated from the standard curve generated using commercially available Rituximab. The supernatant from the sham-transfected cells (WFI) served as a control.

FIG. 46 shows for Example 10 the expression of anti-RSV F antibodies by mRNA transfected cells evaluated by Western blot analysis. Aliquots of cell lysates and supernatants were separated by SDS-PAGE, blotted onto a membrane, and stained with an anti-human detection antibody recognizing heavy as well as light chain. 100 ng of a recombinant antibody were used as positive control and for rough quantification of mRNA-mediated antibody expression. Mock-transfected cells served as negative control.

EXAMPLES

The Examples shown in the following are merely illustrative and shall describe the present invention in a further way. These Examples shall not be construed to limit the present invention thereto.

Example 1: Preparation of an mRNA Encoding Heavy and Light Chain Variable Regions and Antibody Expression

1.1 Preparation of Expression Vectors for Modified RNA Sequences:

For the production of modified RNA sequences according to the invention, the GC-enriched and translation-optimized DNA sequences which code for a heavy chain and a light chain of the antibodies shown below in Table 12 (e.g. cetuximab (Erbitux), trastuzumab (Herceptin) and rituximab (Rituxan), cf. SEQ ID NO: 61161-61175, where SEQ ID NO: 61161, 61163, 61166, 61168, 61171 and 61173 represent the particular coding sequences which are not GC-optimized of the heavy and the light chains of these antibodies and SEQ ID NO: 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174, and 61175 represent the coding GC-enriched sequences (see above)) were cloned into the pCV19 vector (CureVac GmbH) by standard molecular biology methods. To ensure equimolar expression of the two chains, an IRES (internal ribosomal entry site) was introduced. The mutated 3′ UTR (untranslated region) of the alpha-globin gene and a polyA-polyC tail at the 3′ end serve for additional stabilizing of the mRNA. The signal peptide of the HLA-A*0201 gene is coded for secretion of the antibody expressed. A His tag was additionally introduced for detection of the antibody. FIG. 6 shows the expression constructs used for cetuximab (Erbitux), trastuzumab (Herceptin) and rituximab (Rituxan).

TABLE 12 SEQ ID NOs of exemplified and preferred antibodies encoded by the mRNA according to the present invention and of exemplified and preferred mRNAs according to the invention Protein heavy Protein light Optimized CDS Optimized CDS chain (SEQ ID chain (SEQ ID heavy chain light chain mRNA sequence Antibody NO) NO) (SEQ ID NO) (SEQ ID NO) (SEQ ID NO) Cetuximab 61237 61238 61240 61241 61243 (“R3578”) (Erbitux) Trastuzumab 61270 61271 61273 61274 61276 (“R1965”) Rituximab 61303 61305 61306 61308 61310 (Rituxan) (“R3001”) Blinatumomab 61640 — 61642 (single — 61643 (“R3981”) (single chain) chain) Anti-BoNTx_v1 61603 61606 61604 61607 61605 (heavy chain; R4120”) 61608 (light chain; “R4122”) Anti-BoNTx_v2 61609 61612 61610 61613 61611 (heavy chain; R5045”) 61614 (light chain; “R5046”) Anti-HA 61456 61457 61458 61459 61465 CR8033_v1 (“R3996”) Anti-HA 61469 61470 61471 61472 61474 CR8033_v2 (“R3998”) Anti-HA 61475 61476 61477 61478 61480 CR8033_v3 (“R4000”) Anti-HA 61481 61482 61483 61484 61486 CR8033_v4 (“R4002”) Anti-HA 61487 61488 61489 61490 61492 CR8033_v5 (“R4004”) Anti-HA 61493 61494 61495 61496 61498 CR8033_v6 (“R4012”) Anti-Rabies 61408 61412 61409 61413 61410 (heavy chain; “R4116”) 61414 (light chain; “R4118”) Anti-Rabies 61384 61385 61402 61403 61405 (“R3059”) Anti-HIV 61370 61381 61371 61382 61372 (heavy chain; “R5319”) 61383 (light chain; “R5320”) Rituximab 61320 61332 61321 61333 61337 (Rituxan) (“R3917”) Anti-RSV F 61675 61697 61676 61698 61677 (heavy chain; “R4179”) 61699 (light chain; “R4181”) Anti-RSV F 61686 61708 61687 61709 61688 (heavy chain; “R4180”) 61710 (light chain; “R4182”) Anti-RSV F 61660 61661 61662 61663 61666 (“R3060”)

Table 13 below shows further RNA constructs, which were produced, including their SEQ ID NOs and the antibodies, which they encode.

TABLE 13 SEQ ID NOs of exemplified and preferred mRNAs according to the invention encoding the indicated antibodies. RNA construct name SEQ ID NO Encoded antibody R3578 61243 Cetuximab (Erbitux) R3000 61244 Cetuximab (Erbitux) R1965 61276 Trastuzumab (Herceptin) R2999 61277 Trastuzumab (Herceptin) R3012 61278 Trastuzumab (Herceptin) R3001 61310 Rituximab R3484 61311 Rituximab R4128 61322 Rituximab R5910 61323 Rituximab R4129 61334 Rituximab R5911 61335 Rituximab R3917 61337 Rituximab R4126 61348 Lexatumumab R4127 61359 Lexatumumab R3985 61361 Lexatumumab R5319 61372 VRC01 R5320 61383 VRC01 R3059 61404 SO57 R3059 61405 SO57 R3061 61406 SO57 R4634 61407 SO57 R4116 61410 SO57 R4635 61411 SO57 R4118 61414 SO57 R4636 61415 SO57 R4640 61416 SO57 R4640 61417 SO57 R5230 61428 anti-rabies_Mouse_ab R5231 61439 anti-rabies_Mouse_ab R4112 61460 CR8033 R4530 61461 CR8033 R4114 61462 CR8033 R4531 61463 CR8033 R3996 61465 CR8033 R4633 61466 CR8033 R4639 61467 CR8033 R4639 61468 CR8033 R3998 61473 CR8033 R3998 61474 CR8033 R4000 61479 CR8033 R4000 61480 CR8033 R4002 61485 CR8033 R4002 61486 CR8033 R4004 61491 CR8033 R4004 61492 CR8033 R4012 61497 CR8033 R4012 61498 CR8033 R4007 61520 5J8 R4008 61542 FLA5.10 R4010 61564 PN-SIA49 R5417 61575 Ipilimumab R5418 61586 Ipilimumab R4120 61603 anti-BoNT-A R4120 61604 anti-BoNT-A R4120 61605 anti-BoNT-A R4122 61606 anti-BoNT-A R4122 61607 anti-BoNT-A R4122 61608 anti-BoNT-A R5045 61609 anti-BoNT-A R5045 61610 anti-BoNT-A R5045 61611 anti-BoNT-A R5046 61612 anti-BoNT-A R5046 61613 anti-BoNT-A R5046 61614 anti-BoNT-A R3118, R3729 61615 anti-BoNT-A R3118 61616 anti-BoNT-A R3729 61617 anti-BoNT-A R3979 61638 Blinatumomab R3981 61643 Blinatumomab R3058 61665 anti-RSV R3060 61666 anti-RSV R4179 61677 anti-RSV R4180 61688 anti-RSV R4181 61699 anti-RSV R4182 61710 anti-RSV R4124 61721 anti-VEGFR2 R4125 61732 anti-VEGFR2 R3983 61733 anti-VEGFR2 R3983 61734 anti-VEGFR2

1.2 Preparation of the G/C-Enriched and Translation-Optimized Antibody-Coding mRNA

An in vitro transcription was carried out by means of T7 polymerase (T7-Opti mRNA Kit, CureVac, Tubingen, Germany), followed by purification with Pure Messenger™ (CureVac, Tubingen, Germany). For this, a DNase digestion was first carried out, followed by an LiCI precipitation and thereafter an HPLC using a porous reverse phase as the stationary phase (PURE Messenger).

1.3 Cell Lines

RNA-based expression of humanised antibodies was done in either CHO-K1 or BHK-21 (Syrian hamster kidney, HER2-negative) cells. The tumour cell lines BT-474, A-431 and Raji strongly expressing HER2, EGFR and CD20, respectively, were used to record antibody levels by FACS analysis. All cell lines except CHO were maintained in RPMI medium supplemented with FCS and glutamine according to the supplier's information. CHO cells were grown in Ham's F12 supplemented with 10% FCS. All cell lines were obtained from the German collection of cell cultures (DSMZ, Braunschweig, Germany).

1.4 Antibody Expression

Various amounts of mRNA (G/C enriched as defined by FIGS. 12, 17, 22, 25, 26, 27) encoding the humanised antibodies Herceptin, Erbitux, and Rituxan, respectively, were transfected into either CHO or BHK cells by electroporation (300 V, 450 μF for CHO and 300 V, 150 μF for BHK). After transfection, cells were seeded onto 24-well cell culture plates at a density of 200.000 to 400.000 cells per well. For collection of secreted protein, medium was replaced by 250 μl of fresh medium after cell attachment to the plastic surface. Secreted protein was collected for 24-96 hours and stored at 4° C. In addition, cells were harvested into 50 μl of phosphate buffered saline (1×PBS buffer) containing 0.5% BSA and broken up by three freeze-thaw cycles. Cell lysates were cleared by centrifugation and stored at −80° C.

1.5 Western Blot Analysis

In order to detect translation of transfected RNA, proteins from either cell culture supernatants or cell lysates were separated by a 12% SDS-PAGE and blotted onto a nitrocellulose membrane. Humanised antibodies Herceptin (Roche), Erbitux (Merck KGAA), and Mabthera=Rituxan (Roche) were used as controls. After blotting was completed, membranes were consecutively incubated with a biotinylated goat anti-human IgG antibody (Dianova), streptavidin coupled to horseradish peroxidase (BD), and a chemiluminescent substrate (SuperSignal West Pico, Pierce). Staining was detected with a Fuji LAS-1000 chemiluminescence camera. Results are shown in FIG. 23.

1.6 FACS Analysis

Functional antibody formation can be demonstrated by FACS staining of antigen-expressing target cells. In order to examine the production of functional antibodies, cell culture supernatants of RNA-transfected cells were collected after 48 to 96 hours. Approximately 200.000 target cells expressing the respective antigen were incubated with either control antibodies (Herceptin, Erbitux, Mabthera) or cell culture supernatants. For detection of bound antibodies, cells were stained with biotinylated goat anti-human IgG antibody (Dianova) and PE-labelled streptavidin (Invitrogen). Cells were analysed on a FACSCalibur (BD).

Example 2: Effects of an mRNA Encoding Trastuzumab (Herceptin) in an In Vivo Tumor Model

2.1 Preparation of mRNA

For the present example a DNA sequence encoding the Trastuzumab protein was prepared and used for subsequent in vitro transcription reactions as described in Example 1.

Briefly, a vector for in vitro transcription was constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and light chain of the Trastuzumab antibody, separated by the internal ribosomal entry site (IRES) from Encephalomyocarditis virus (EMCV). An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. This DNA construct is shown in FIGS. 22 and 39 (SEQ ID NO: 61175). This vector was transcribed in vitro in the presence of a cap analog resulting in 5′-capped (m7G) mRNA (“R1965”).

2.2 Animal Study

Before the start of the experiment, 7 weeks old female BALB/c nu/nu mice (n=14 per group) were subcutaneously implanted with slow-release estrogen pellets (0.72 mg 17β-estradiol) because the BT-474 cell line is estrogen receptor positive and estrogen enhances tumorigenicity. Mice were inoculated subcutaneously with 10×10⁶ BT-474 tumour cells (100 μl of a cell/matrigel suspension) per mouse on day 0. Treatment was started on day 11 when tumors became injectable. Mice were treated twice weekly for up to 3.5 weeks with a single dose of 50 μg of mRNA (R1965) in a 50 μl injection volume (Ringer Lactate buffer).

2.3 Statistical Analysis

The statistical difference in survival was evaluated using Mantel-Cox (p=0.0499) and Gehan-Breslow (p=0.0425) tests, which assume the proportional hazards or give more weight to deaths at early time points, respectively.

2.4 Results

Results are shown in FIG. 28. This experiment demonstrates the effectiveness of the mRNA-encoded antibody Trastuzumab with respect to enhancing survival of nude BALB/c mice harboring a human tumor cell xenograft (BT-474 breast cancer cell line). The Her-2 positive tumor cell line BT-474 was used to establish tumors which were then treated by intratumoral injections of mRNA encoding the anti-Her-2 antibody Trastuzumab. The effectiveness of treatment was demonstrated by prolonged survival of treated animals compared to untreated animals (FIG. 28). The median survival time compared to untreated mice was increased by 5.5 days.

Example 3: In Vitro and In Vivo Effects of an mRNA Encoding Cetuximab (Erbitux)

3.1 Preparation of mRNA

For the present example a DNA sequence encoding the Cetuximab protein was prepared and used for subsequent in vitro transcription reactions as described in Example 1.

Briefly, a vector for in vitro transcription was constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and light chain of the Cetuximab antibody, separated by the internal ribosomal entry site (I RES) from Encephalomyocarditis virus (EMCV). An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. This DNA construct is shown in FIGS. 17 and 40 (SEQ ID NO: 61170). This vector was transcribed in vitro.After in vitro transcription, the mRNA was enzymatically capped and polyadenylated. The resulting mRNA was termed “R3578”.

3.2 In Vitro Expression of the Antibody Cetuximab

The expression of functional antibodies by mRNA-encoded Cetuximab was evaluated in vitro. To this end, HEK293T cells were transfected with 1 μg or 4 μg of mRNA (R3578) using the Lipofectamine2000 reagent. 24 hours after the transfection, the supernatant was collected and used for staining of A431 cells (EGFR-expressing cell line) and analysed by flow cytometry (FACS). The concentration of Cetuximab in the supernatant of the transfected cells was calculated using a standard curve generated with the commercially available Cetuximab protein. As shown in FIG. 29, transfection with 4 μg of mRNA (R3578) resulted in the production of functional antibodies at the concentration of approximately 40 ng/ml.

3.3 Animal Study

6-7 weeks old female BALB/c nu/nu mice (n=10) were inoculated subcutaneously in the right flank (near the dorsal region) with a cell suspension of about 5×10⁶ SW48 cells (human colon cancer cell line; 100 μl of a cell/matrigel suspension). When the tumor reached a volume of 400-500 mm³, the tumor tissue blocks were harvested for transplantation. SW48 tumor blocks (about 1.5 mm×1.5 mm×1.5 mm in size) were subcutaneously transplanted in the right flank (near the dorsal region) of 125 animals; eventually 40 tumor-bearing mice were enrolled in the study. The animals were weighed and randomized into treatment groups when the tumor size reached a volume of 100-150 mm³. The date to start treatment was designated as day 0. All groups consisted of 10 animals each. The mRNA or Ringer lactate buffer was administered in a 50 μl volume intratumorally as shown in Table 14.

TABLE 14 Group designation and dosing schedule No. Frequency of an- and days of dosing Group imals Treatment Dose (after randomization) 1 10 Untreated — — 2 10 Ringer Lactate — Every 3 days for a total number of 7 injections 3 10 R3578 (Cetuximab 100 μg Every 3 days for a total (Erbitux) SEQ ID number of 7 injections NO: 61243) 4 10 R3578 (Cetuximab  50 μg Every 3 days for a total (Erbitux) SEQ ID number of 7 injections NO: 61243)

Animals in a deteriorating condition with a body weight loss greater than 30% or bearing a tumor exceeding 2,000 mm³ in size were euthanized.

Tumor volume, expressed in mm³, was calculated using the following formula, in which “a” and “b” are the long and the short diameters of a tumor, respectively.

V(mm³)=(a×b ²)/2

Statistical Analysis

The statistical difference in survival was evaluated using Mantel-Cox and Gehan-Breslow tests, which assume the proportional hazards or give more weight to deaths at early time points, respectively. The hazard ratio (logrank) as part of the survival analysis of two data sets was included in the results. Hazard is defined as the slope of the survival curve and the hazard ratio compares the rate of death between two groups. The statistical difference between groups was evaluated using Mann-Whitney test.

Results

This experiment demonstrates the efficacy of the mRNA-encoded antibody Cetuximab with respect to enhancing survival of nude BALB/c mice harboring a human tumor cell xenograft (SW48 human colon cancer cell line).

As shown in FIG. 30, compared to the buffer-treated mice, the treatment with R3578 increased the time to the first death incident by 20% (7 days; first incident at day 42 compared to day 35 in RiLa-treated mice) in the group injected with 100 μg of mRNA-encoded Cetuximab (FIG. 30A) and approximately 15% (5 days) in the group treated with 50 μg of R3578 (FIG. 30B). Moreover, at day 51 all mice in the RiLa group were dead, whereas in total four mice treated with R3578 were still alive (one mouse in group treated with 100 μg R3578 and three mice treated with 50 μg R3578) were still alive. Consequently, the median survival time compared to RiLa-injected mice was increased in animals treated with 100 μg or 50 μg of mRNA-encoded Cetuximab.

To confirm the expression and functionality of mRNA-encoded Cetuximab in vivo, the sera from mice injected with 100 μg and 50 μg of R3578 were collected 24 hours after the third application and tested by flow cytometry (FACS) for the presence of functional antibodies as described above. The sera from untreated animals and mice injected with RiLa served as controls. As shown in FIG. 31, Cetuximab antibodies were clearly detectable in both groups injected with R3578 confirming the in vivo expression and functionality (capability to bind to EGFR) of mRNA-encoded antibodies.

Example 4: Effects of an mRNA Encoding a Single Chain, Bispecific Antibody (Blinatumomab) in an In Vivo Tumor Model

As a further example, mRNA coding for Blinatumomab was tested in vivo (a bispecific anti-CD3/anti-CD19 antibody).

4.1 Preparation of mRNA

For the present example a DNA sequence encoding the Blinatumomab antibody was prepared and used for subsequent in vitro transcription reactions in a similar manner as described in Example 1, except that the antibody encoded by the mRNA was Blinatumomab.

Briefly, a vector for in vitro transcription was constructed containing a T7 promoter and a GC-enriched sequence coding for Blinatumomab (a fusion protein consisting of the variable regions of two single-chain monoclonal antibodies (scFvs)—CD19 and CD3—covalently linked by a non-immunogenic five-amino acid chain). An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction enzyme site used for linearization of the vector before in vitro transcription. The respective CDS sequence as well as the sequence of the mRNA can be retrieved from Table 12 (Example 1). This vector was transcribed in vitro in the presence of a cap analog resulting in 5′-capped (m7G) mRNA (“R3981”).

4.2 Animal Study

NOG female mice (n=6 per group) were inoculated subcutaneously in the right flank with a cell suspension consisting of 1×10⁶ NALM-6 cells (human pre-B cell leukemia) and 1×10⁸ freshly isolated human PBMCs (peripheral blood mononuclear cells). The NALM-6 cells were co-injected together with human peripheral mononuclear cells (PBMCs) as source of human T-cells because Blinatumomab as a bispecific antibody recognizes the CD19 protein on the human NALM-6 cells and the CD3 protein on the human T cells. One hour after cell inoculation mice were treated by peritumoral injections of the mRNA encoding Blinatumomab (“R3981”; 100 μg) or buffer (Ringer Lactate) as a control and this treatment was repeated on five consecutive days. The detailed group description is depicted in Table 15.

TABLE 15 Animal groups and dosing schedule. No. Treatment Group of animals PBMCs Treatment Dose schedule 1 6 — Ringer Lactate — At five consecutive days beginning at day 0 2 6 + Ringer Lactate — At five consecutive days beginning at day 0 3 6 + R3981 100 μg At five (Blinatumomab consecutive SEQ ID NO: days beginning 61643) at day 0

The animal health status was checked daily. Animals in a deteriorating condition with a body weight loss greater than 20% or bearing a tumor exceeding 2 cm³ in size were euthanized.

Tumor volume, expressed in cm³, was calculated using the following formula, in which “a” and “b” are the long and the short diameters of a tumor, respectively.

V(cm³)=(a×b ²)/2

Statistical Analysis

The statistical analysis of tumor growth curves was performed using 2-way ANOVA test with Bonferroni post test. The statistical analysis of differences in tumor volume at day 34 was performed using t-test with Welch's correction (the data were normally distributed as determined by Kolmogorov-Smirnov normality test). The statistical difference in survival was evaluated using Mantel-Cox test.

Results

This experiment shows the efficacy of the mRNA-encoded Blinatumomab antibody in terms of reduction of tumor growth and enhancing survival of NOG mice harboring a human cell xenograft (NALM-6 human pre-B leukemia cells).

Subcutaneously injected NALM-6 cells developed palpable tumors in control treated mice at day 25. Thereafter, the tumor rapidly increased in size in all buffer-treated animals (FIG. 32). Contrary to the control group, only one of six mice in the cohort treated with the mRNA-encoded Blinatumomab developed a measurable tumor. As a result, a statistically significant inhibition of tumor growth in the group injected with R3981 in comparison to buffer-treated mice was observed.

To further demonstrate the impact of the mRNA-encoded Blinatumomab treatment on the growth of the subcutaneously injected NALM-6 cells the tumor volume of each mouse at day 34 was depicted (FIG. 33). Day 34 was chosen for this analysis as the last day when all animals in all groups were still alive and therefore the mean tumor volumes can be compared. As shown in FIG. 33, treatment with R3981 significantly inhibited tumor growth compared to the buffer control.

In addition to the effect on tumor growth, the difference in survival between the experiments groups was evaluated. As shown in FIG. 34, treatment with the mRNA-encoded Blinatumomab significantly enhanced mice survival compared to the buffer-treated animals. At day 49, all animals in the R3981-treated group were alive (5/6 mice were completely tumor-free and only one mouse had a measurable tumor) compared to the control group where five of six animals were already dead. Consequently, the R3981-treated group had an undefined median survival time (MS), whereas the buffer-treated group reached MS at 38.25 days. Thus treatment with the mRNA encoding Blinatumomab significantly enhanced the survival compared to the buffer-treated animals.

Example 5: In Vitro Expression of mRNA-Encoded Anti-BoNTx Antibody

In this experiment the in vitro expression of mRNA-encoded anti-BoNTx antibody was evaluated.

5.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directed against the Botulinum neurotoxin (BoNTx) (Amersdorfer et al., 1997. Infect. Immun. 65(9):3743-52) were prepared and used for subsequent in vitro transcription reactions. Heavy (HC) and light (LC) chain of the antibody were encoded as separate entities and constructs differed regarding signal peptides used for protein secretion (Table 16).

Vectors for in vitro transcription were constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and light chain of the antibody, respectively. An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. The respective CDS sequences as well as the sequences of the mRNA can be retrieved from Table 12 (Example 1). For capping of the mRNA, in vitro transcription was conducted in the presence of cap analog.

TABLE 16 mRNA constructs encoded signal mRNA antibody peptide RNA design R5045 (any of SEQ ID NOs anti- HLA-2 HC and LC 61609-61611)/R5046 (any BoNTx encoded on of SEQ ID NOs 61612-61614) separate mRNA molecules R4120 (any of SEQ ID NOs anti- immuno- HC and LC 61603-61605)/R4122 (any BoNTx globulin encoded on of SEQ ID NOs 61606-61608) separate mRNA molecules

5.2 In Vitro Expression of the Anti-BoNTx Antibody Evaluated by Western Blot Analysis

The expression of mRNA-encoded anti-BoNTx antibody was evaluated in vitro. To this end, BHK cells were transfected with 10 μg of mRNA using the Lipofectamine2000 reagent. 24 hours after the transfection, cells and supernatants were collected for Western blot analysis to determine the expression of human antibodies.

5.3 Results

As shown in FIG. 35, human antibodies were clearly detectable in lysates and supernatants of mRNA-transfected cells. The mRNA-transfected cells produced both, heavy and light chain, and gave rise to high and equivalent levels of both chains in the supernatant, thus strongly suggesting the production of correctly folded and assembled antibodies. Expression was specific as no antibodies were detected in the supernatants of mock-transfected cells.

Example 6: In Vitro Expression of mRNA-Encoded Anti-Influenza (Anti-HA) Antibody

In these experiments the in vitro expression and binding to the native antigen of mRNA-encoded CR8033 (anti-HA: anti-hemagglutinin) antibody was evaluated.

6.1 Preparation of mRNA

For the present example DNA sequences encoding the CR8033 anti-hemagglutinin antibody (Dreyfus et al., 2012. Science 337(6100):1343-8) were prepared and used for subsequent in vitro transcription reactions. The antibody was represented by bi-cistronic sequences in which heavy chain (HC) and light chain (LC) were separated by the internal ribosomal entry site (IRES) from either Encephalomyocarditis (EMCV) or Foot-and-mouth disease (FMDV) virus. Moreover, sequences varied with respect to the order of heavy and light chain or utilized different signal peptides for the secretion of both chains (Table 17).

Vectors for in vitro transcription were constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and light chain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. The respective CDS sequences as well as the sequences of the mRNA can be retrieved from Table 12 (Example 1). For capping of the mRNA, in vitro transcription was conducted in the presence of cap analog.

TABLE 17 mRNA constructs encoded mRNA antibody signal peptide RNA design R3996 (SEQ ID CR8033 immunoglobulin HC:EMCV-IRES:LC NO: 61465) (anti-HA) R4000 (SEQ ID CR8033 Albumin (ALB) HC:EMCV-IRES:LC NO: 61479, (anti-HA) 61480)

6.2 In Vitro Expression of the CR8033 Antibody Evaluated by Western Blot Analysis

The expression of antibodies by mRNA-encoded CR8033 was evaluated in vitro. To this end, BHK cells were transfected with 10 μg of mRNA using the Lipofectamine2000 reagent. 24 hours after the transfection, cells and supernatants were collected for Western blot analysis to determine the expression of human antibodies.

6.3 In Vitro Expression of Functional CR8033 Antibody Evaluated by Flow Cytometry

To confirm the functionality of the in vitro-produced mRNA-encoded antibody, the supernatant obtained after transfection of BHK cells (as described above) was used for staining of hemagglutinin (HA) expressing HeLa cells. To this end, HeLa cells were transfected with 1 μg of HA-expressing mRNA using the Lipofectamine2000 reagent and, after staining, analyzed by flow cytometry (FACS). The expression is presented as median fluorescence intensity.

6.4 Results

As shown in FIG. 36, mRNA-transfected cells produced both, heavy and light chain, and gave rise to high and equivalent levels of both chains in the supernatant, thus strongly suggesting the production of correctly folded and assembled antibodies. Expression was specific as no antibodies were detected in the supernatants of mock-transfected cells.

As shown in FIG. 37, all antibody-encoding mRNAs resulted in the production of functional antibodies.

Example 7: In Vitro and In Vivo Expression of mRNA-Encoded Anti-Rabies (anti-RAV G) Antibody

In this experiment the in vitro expression and binding to the native antigen of mRNA-encoded anti-RAV G antibody was evaluated.

7.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directed against the Rabies virus glycoprotein (RAV G) (SO57 antibody; Prosniak et al., 2003. J. Infect. Dis. 188(1):53-6) were prepared and used for subsequent in vitro transcription reactions. Heavy (HC) and light (LC) chain of the antibody were either linked by the internal ribosomal entry site (IRES) from Encephalomyocarditis virus (EMCV) or encoded as separate entities (Table 18).

Vectors for in vitro transcription were constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and/or light chain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. The respective CDS sequences as well as the sequences of the mRNA can be retrieved from Table 12 (Example 1). For capping of the mRNA, in vitro transcription was conducted in the presence of cap analog.

TABLE 18 mRNA constructs encoded signal mRNA antibody peptide RNA design R4116 (SEQ ID NO: anti-RAV G immuno- HC and LC encoded 61410)/R4118 (SEQ globulin on separate ID NO: 61414) mRNA molecules R3059 (SEQ ID NO: anti-RAV G immuno- HC:EMCV-IRES:LC 614104/61405) globulin

7.2 In Vitro Expression of the Functional Anti-RAV G Antibody Evaluated by Flow Cytometry

To demonstrate functionality of in vitro-produced mRNA-encoded antibody, the supernatant obtained after transfection of BHK cells was used for staining of RAV G expressing HeLa cells. To this end, BHK cells were transfected with 10 μg of antibody-encoding mRNA and HeLa cells were transfected with 1 μg of RAV G-expressing mRNA, respectively, using the Lipofectamine2000 reagent. After staining, HeLa cells were analyzed by flow cytometry (FACS). The expression level of the anti-RAV G antibody is presented as median fluorescence intensity.

7.3 Results

As shown in FIG. 38, all antibody-encoding mRNAs resulted in the production of functional antibodies. However, the antibody produced from mRNA molecules separately encoding heavy chain and light chain produced higher antibody levels as compared to the antibody produced from an mRNA molecule encoding both, heavy chain and light chain. All antibodies were functional as they recognized and bound RAV G antigen expressed on the surface of HeLa cells. Encoding heavy and light chain by separate mRNA molecules instead of a bi-cistronic construct strongly increased the amount of functional antibodies secreted by mRNA-transfected cells.

Example 8: In Vitro Expression of mRNA-Encoded Anti-HIV Antibody

In this experiment the in vitro expression and neutralization activity to the HIV-1Ba-L HIV strain was tested for RNA-encoded antibodies.

8.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directed against the HIV (VRC01; Wu et al., Science 329(5993):856-861, 2010) were prepared and used for subsequent in vitro transcription reactions. Heavy (HC) and light (LC) chain of the antibody were encoded as separate entities (Table 19). For the heavy chains of VRC01, the sequence of the IgG constant region of S057 and the sequence of an immunoglobulin kappa light chain constant region (GenBank: AGH70219.1) was used.

Vectors for in vitro transcription were constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and/or light chain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. The respective CDS sequences as well as the sequences of the mRNA can be retrieved from Table 12. For capping of the mRNA, in vitro transcription was conducted in the presence of cap analog. Cells were transfected with lipofectamin 2000 complexed mRNA.

TABLE 19 mRNA constructs mRNA construct encoded antibody RNA design R5319 (SEQ ID NO: VRC01 HC and LC encoded on 61372)/R5320 (SEQ separate mRNA molecules ID NO: 61383)

8.2 In Vitro Expression of the Functional Anti-HIV Antibody Evaluated by IgG ELISA

To demonstrate expression of in vitro-produced mRNA-encoded antibody, the supernatant obtained after transfection of BHK cells was subjected to an IgG-specific ELISA where plates were coated with an anti-human IgG antibody. Antibody detection was obtained in a plate reader.

8.3 In Vitro Functionality of an Anti-HIV Antibody Evaluated in MAGI-R5 Cells—Inhibitory Effect on HIV Infection

The inhibitory activity of the mRNA-encoded antibody of the invention on HIV infection is measured on the human MAGI R5 recombinant cell line coexpressing the human CCR5 receptor and CD4 at their extracellular membrane. The cells used in the assay contain the HIV-1 LTR promoter that drives expression of β-gal upon infection (this driven by the interaction of tat and the LTR).

Consequently, to demonstrate the functionality of anti-HIV antibody, the supernatant obtained after transfection of BHK cells was subjected to the virus entry test using MAGI-R5 cells which report the entry of HIV by chemo luminescence (Magi R5-Tropic Antiviral Assay performed at Southern Research, Maryland, USA). Inhibition of virus entry correlates with reduced RLU (relative light units). Upon virus entry, the receptor (CCR5) fused to beta-gal is expressed which is detected by chemo-luminescence, thus, the lower the RLU values the more inhibition of virus entry is observed.

8.4 Results

As shown in FIG. 42, mRNA encoding anti-HIV antibody expressed antibodies.

As shown in FIG. 43, increasing concentrations of expressed anti-HIV antibody reduced virus entry in MAGI cells (CC=cell control containing cells only; VC=virus control containing also virus). Included as a control was commercially available recombinant VRC01 (FIG. 43C). mRNA-encoded VRC01 (FIG. 43B) inhibited the entry of HIV similar to recombinant VRC01 (FIG. 43C). Thus, the mRNA-encoded antibody of the invention is able to protect a human recombinant cell line (MAGI R5 cell) from the infection by a HIV virus.

Example 9: In Vitro Expression of mRNA-Encoded Rituximab

In these experiments the in vitro expression of mRNA-encoded Rituximab and binding to its native antigen was evaluated.

9.1. Preparation of mRNA

For the present example a DNA sequence encoding the Rituximab protein was prepared and used for subsequent in vitro transcription reactions.

A vector for in vitro transcription was constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and light chain of the Rituximab antibody, separated by the internal ribosomal entry site (IRES) from Encephalomyocarditis virus (EMCV). An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. This vector was transcribed in vitro in the presence of a cap analog resulting in 5′-capped (m7G) mRNA (R3917; SEQ ID NO: 61337).

9.2 In Vitro Expression of the Rituximab Antibody Evaluated by ELISA

The expression of functional antibodies by mRNA-encoded Rituximab was evaluated in vitro. To this end, HEK293T cells were transfected with 1 μg or 4 μg of mRNA (R3917) using the Lipofectamine2000 reagent. 24 hours after the transfection, the supernatant was collected and used in ELISA to determine the expression of human antibodies.

9.3 In Vitro Expression of the Functional Rituximab Antibody Evaluated by Flow Cytometry

To confirm the functionality of the in vitro-produced mRNA-encoded Rituximab, the supernatant obtained after transfection of HEK293T cells (as described above) was used for staining of Raji cells (the cell line expressing human CD20) and the cells were analysed by flow cytometry (FACS). The concentration of Rituximab in the supernatant of the transfected cells was calculated using a standard curve generated with the commercially available Rituximab protein.

9.4 Results

In these experiments the in vitro expression of mRNA-encoded Rituximab and binding to its native antigen was evaluated.

As shown in FIG. 44, the concentration of over 10 ng/ml of human antibodies was detected in the supernatant of cells transfected with 4 μg of R3917, the expression was dose-dependent and specific as no antibodies were detected in the supernatants of the sham-transfected cells. These antibodies were functional as they recognized and bound CD20 antigen expressed on the surface of Raji cells (FIG. 45). The estimated concentration of the antibodies using ELISA (here, a method that measures human antibodies) and flow cytometry (here, a method that measures only functional Rituximab) was similar suggesting that all antibodies detected in the supernatant are fully functional.

Example 10: In Vitro Expression of mRNA-Encoded Anti-RSV F Antibody

In this experiment the in vitro expression of an mRNA-encoded antibody against human respiratory syncytial virus F protein (anti-RSV F antibody; Palivizumab) was investigated.

10.1 Preparation of mRNA

For the present example DNA sequences encoding an antibody directed against the human respiratory syncytial virus F protein (RSV F) (Synagis antibody) were prepared and used for subsequent in vitro transcription reactions. Heavy (HC) and light (LC) chain of the antibody were either linked by the internal ribosomal entry site (IRES) from Encephalomyocarditis virus (EMCV) or encoded as separate entities (Table 20). Vectors for in vitro transcription were constructed containing a T7 promoter and a GC-enriched sequence coding for the heavy and/or light chain of the antibody. An α-globin 3′-UTR, followed by an A64 poly(A) sequence and a C30 sequence, was inserted 3′ of the open reading frame (ORF). The C30 sequence was followed by a restriction site used for linearization of the vector before in vitro transcription. For capping of the mRNA, in vitro transcription was conducted in the presence of cap analog.

TABLE 20 mRNA constructs encoded mRNA construct antibody RNA design R4179 (SEQ ID NO: anti-RSV F immuno- HC and LC encoded 61677)/R4181 (SEQ globulin on separate ID NO: 61699) mRNA molecules R4180 (SEQ ID NO: anti-RSV F immuno- HC and LC encoded 61688)/R4182 (SEQ globulin on separate ID NO: 61710) mRNA molecules R3060 (SEQ ID NO: anti-RSV F HLA-2 HC:EMCV-IRES:LC 61666)

10.2 In vitro expression of the anti-RSV-F antibodies evaluated by Western blot analysis The expression of mRNA-encoded anti-RSV F antibody was evaluated in vitro. To this end, BHK cells were transfected with 10 μg of mRNA using the Lipofectamine2000 reagent. 24 hours after the transfection, cells and supernatants were collected for Western blot analysis to determine the expression of human antibodies.

10.3 Results

As shown in FIG. 46, human antibodies were clearly detectable in lysates and supernatants of mRNA-transfected cells. However, the antibody level was strongly dependent on the format of antibody representation. The mRNA-transfected cells produced both, heavy and light chain, while encoding heavy and light chain by separate mRNA molecules instead of a bi-cistronic construct strongly improved the ratio of heavy and light chain, thus giving rise to almost equivalent levels of both chains. Expression was specific as no antibodies were detected in the supernatants of mock-transfected cells. 

1. An RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of nucleic acid sequences according to SEQ ID NOs: 7643-61136, 61161-61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734 or a fragment of any of said nucleic acid sequences that encode an antigen-binding fragment of an antibody.
 2. The RNA according to claim 1, wherein the at least one coding sequence comprises a nucleic acid sequence selected from the group consisting of nucleic acid sequences according to SEQ ID NO: 7643-61136, 61162, 61164, 61165, 61167, 61169, 61170, 61172, 61174, 61175, 61209-61211, 61215-61235, 61239-61242, 61248-61268, 61272-61275, 61282-61302, 61306-61309, 61313-61319, 61321, 61325-61331, 61333, 61336, 61339-61345, 61347, 61350-61356, 61358, 61360, 61363-61369, 61371, 61374-61380, 61382, 61386-61399, 61402-61404, 61416, 61419-61425, 61427, 61430-61436, 61438, 61442-61455, 61458, 61459, 61464, 61467, 61471-61473, 61477-61479, 61483-61485, 61489-61491, 61495-61497, 61501-61514, 61517-61519, 61523-61536, 61539-61541, 61545-61558, 61561-61563, 61566-61572, 61574, 61577-61583, 61585, 61589-61602, 61604, 61607, 61610, 61613, 61615, 61620-61633, 61636, 61637, 61641, 61642, 61646-61659, 61662-61664, 61668-61674, 61676, 61679-61685, 61687, 61690-61696, 61698, 61701-61707, 61709, 61712-61718, 61720, 61723-61729, 61731, 61733, 61243, 61244, 61276, 61277, 61278, 61310, 61311, 61322, 61323, 61334, 61335, 61337, 61348, 61359, 61361, 61372, 61383, 61404, 61405, 61406, 61407, 61410, 61411, 61414, 61415, 61416, 61417, 61428, 61439, 61460, 61461, 61462, 61463, 61465, 61466, 61467, 61468, 61473, 61474, 61479, 61480, 61485, 61486, 61491, 61492, 61497, 61498, 61520, 61542, 61564, 61575, 61586, 61603, 61604, 61605, 61606, 61607, 61608, 61609, 61610, 61611, 61612, 61613, 61614, 61615, 61616, 61617, 61638, 61643, 61665, 61666, 61677, 61688, 61699, 61710, 61721, 61732, 61733, and 61734 or a fragment of any of said nucleic acid sequences that encode an antigen-binding fragment of an antibody. 3-6. (canceled)
 7. The RNA according to claim 1, wherein the RNA codes for a CDR encoded by the at least one coding sequence comprises or consists of an amino acid sequence as set forth in any of SEQ ID NOs: 5601-7570.
 8. The RNA according to claim 7, wherein the at least one coding sequence comprises or consists of a nucleic acid sequence as set forth in any of SEQ ID NOs: 13243-15212, 20885-22854, 28527-30496, 36169-38138, 43811-45780, 51453-53422, and 59095-61064.
 9. (canceled)
 10. The RNA according to claim 1, wherein the at least one coding sequence encodes a constant region of an antibody or a fragment thereof.
 11. The RNA according to claim 10, wherein the at least one coding sequence encodes a heavy chain constant region of an antibody or a fragment thereof.
 12. The RNA according to claim 10, wherein the at least one coding sequence encodes a light chain constant region of an antibody or a fragment thereof.
 13. The RNA according to claim 10, wherein the constant region or the fragment or variant thereof encoded by the at least one coding sequence comprises or consists of an amino acid sequence as set forth in any of SEQ ID NOs: 7571-7642.
 14. The RNA according to claim 10, wherein the at least one coding sequence comprises or consists of a nucleic acid sequence as set forth in any of SEQ ID NOs: 15213-15284, 22855-22926, 30497-30568, 38139-38210, 45781-45852, 53423-53494, and 61065-61136.
 15. The RNA according to claim 1, wherein the RNA comprises (i) a coding sequence encoding a heavy chain variable region, or a fragment or variant thereof, and a heavy chain constant region, or a fragment or variant thereof; and/or (ii) a coding sequence encoding a light chain variable region, or a fragment or variant thereof, and a light chain constant region, or a fragment or variant thereof. 16-21. (canceled)
 22. The RNA according to claim 1, wherein the coded antibodies or antibody fragments specifically recognize and bind tumour-specific surface antigens chosen from (TSSA), 5T4, α5β1-integrin, 707-AP, AFP, ART-4, B7H4, BAGE, β-catenin/m, Bcr-abl, MN/C IX-antigen, CA125, CAMEL, CAP-1, CASP-8, β-catenin/m, CD4, CD19, CD20, CD22, CD25, CDC27/m, CD 30, CD33, CD52, CD56, CD80, CDK4/m, CEA, CT, Cyp-B, DAM, EGFR, ErbB3, ELF2M, EMMPRIN, EpCam, ETV6-AML1, G250, GAGE, GnT-V, Gp100, HAGE, HER-2/neu, HLA-A*0201-R1701, HPV-E7, HSP70-2M, HAST-2, hTERT (or hTRT), iCE, IGF-1R, IL-2R, IL-5, KIAA0205, LAGE, LDLR/FUT, MAGE, MART-1/Melan-A, MART-2/Ski, MCI R, myosin/m, MUC1, MUM-1, -2, -3, NA88-A, PAP, proteinase-3, p190 minor bcr-abl, Pml/RARα, PRAME, PSA, PSM, PSMA, RAGE, RU1 or RU2, SAGE, SART-1 or SART-3, survivin, TEL/AML1, TGFβ, TPI/m, TRP-1, TRP-2, TRP-2/INT2, VEGF and WT1, NY-Eso-1 and NY-Eso-B.
 23. The RNA according to claim 1, wherein the at least one coding sequence encodes an antibody selected from the group consisting of AAB-003; Abagovomab; Abciximab; Abituzumab; Abrilumab; Actoxumab; Adalimumab; Aducanumab; Afasevikumab; Aflibercept; Afutuzuab; Afutuzumab; Alacizumab_pegol; Alemtuzumab; Alirocumab; ALX-0061; Amatuximab; Anetumab_ravtansine; Anifrolumab; Anrukinzumab; Apolizumab; Apomab; Aquaporumab; Arcitumomab_99tc; Ascrinvacumab; Aselizuab; Atezolizumab; Atinumab; Atlizuab; Aurograb; Avelumab; Bapineuzumab; Basiliximab; Bavituximab; Begelomab; Benralizumab; Betalutin; Bevacituzuab; Bevacizumab_154-aspartic_acid; Bevacizumab_154-substitution; Bevacizumab_180-serine; Bevacizumab_180-substitution; Bevacizumab_beta; Bevacizumab; Bevacizumab-rhuMAb-VEGF; Bezlotoxumab; Bimagrumab; Bimekizumab; Bleselumab; Blinatumomab; Blinatumumab; Blontuvetmab; Blosozumab; Bococizumab; Brentuximab_vedotin; Briakinumab; Brodalumab; Brolucizumab; Brontictuzumab; BTT-1023; Burosumab; Canakinumab; Cantuzumab; Cantuzumab_mertansine; Cantuzumab_ravtansine; Caplacizumab; Carlumab; Cergutuzumab_amunaleukin; Certolizumab_pegol; Cetuximab; Citatuzumab_bogatox; Cixutumumab; Clazakizumab; Clivatuzumab_tetraxetan; Codrituzumab; Coltuximab_ravtansine; Conatumumab_CV; Conatumumab; Concizumab; Crenezumab; Crotedumab; Dacetuzumab; Dacliximab; Daclizumab; Dalotuzumab; Dapirolizumab_pegol; Daratumumab; Dectrekumab; Demcizumab; Denintuzumab_mafodotin; Denosumab; Depatuxizumab; Depatuxizumab_mafodotin; Dinutuximab_beta; Dinutuximab; Diridavumab; Domagrozumab; Drozituab; Drozitumab; Duligotumab; Duligotuzumab; Dupilumab; Durvalumab; Dusigitumab; Ecromeximab; Eculizumab; Efalizumab; Efungumab; Eldelumab; Elgemtumab; Elotuzumab; Emactuzumab; Emibetuzumab; Emicizumab; Enavatuzumab; Enfortumab; Enfortumab_vedotin; Enoblituzumab; Enokizumab; Enoticumab; Ensituximab; Entolimod; Epratuzumab; Eptacog_beta; Erlizuab; Etaracizumab; Etrolizuab; Etrolizumab; Evinacumab; Evolocumab; Exbivirumab; Farletuzumab; Fasinumab; Fezakinumab; FG-3019; Fibatuzumab; Ficlatuzumab; Figitumumab; Firivumab; Flanvotumab; Fletikumab; Fontolizumab; Foralumab; Foravirumab; Fresolimumab; Fulranumab; Futuximab; Galcanezumab; Galiximab; Ganitumab; Gantenerumab; Gemtuzumab; Gemtuzumab_ozogamicin; Gevokizumab; Girentuximab; Glembatumumab; Goilixiab; Guselkumab; HuMab-001; HuMab-005; HuMab-006; HuMab-019; HuMab-021; HuMab-025; HuMab-027; HuMab-032; HuMab-033; HuMab-035; HuMab-036; HuMab-041; HuMab-044; HuMab-049; HuMab-050; HuMab-054; HuMab-055; HuMab-059; HuMab-060; HuMab-067; HuMab-072; HuMab-084; HuMab-091; HuMab-093; HuMab-098; HuMab-100; HuMab-106; HuMab_10F8; HuMab-111; HuMab-123; HuMab-124; HuMab-125; HuMab-127; HuMab-129; HuMab-132; HuMab-143; HuMab-150; HuMab-152; HuMab-153; HuMab-159; HuMab-160; HuMab-162; HuMab-163; HuMab-166; HuMab-167; HuMab-169; HuMab-7D8; huMAb-anti-MSP10.1; huMAb-anti-MSP10.2; HUMAB-Clone_18; HUMAB-Clone_22; HuMab-L612; HuMab_LC5002-002; HuMab_LC5002-003; HuMab_LC5002-005; HuMab_LC5002-007; HuMab_LC5002-018; Ibalizumab; Ibritumomab_tiuxetan; Icrucumab; Idarucizumab; Igatuzuab; IGF-IR_HUMAB-1A; IGF-IR_HUMAB-23; IGF-IR_HUMAB-8; ImAb1; Imalumab; Imgatuzumab; Inclacumab; Indatuximab_ravtansine; Indusatumab_vedotin; Inebilizumab; Insulin_peglispro; Interferon_beta-1b; Intetumumab; Iodine_(124I)_Girentuximab; Iodine_(131I)_Derlotuxiab_biotin; Iodine_(131I)_Derlotuximab_biotin; Ipilimumab; Iratumumab; Isatuximab; Itolizumab; Ixekizumab; Labetuzumab_govitecan; Lambrolizumab; Lampalizumab; Lanadelumab; Landogrozumab; Laprituximab_emtansine; Lealesoab; Lebrikizumab; Lenercept_chain1; Lenzilumab; Lerdelimumab; Lexatumumab; Libivirumab; Lifastuzumab; Lifastuzumab_vedotin; Ligelizumab; Lilotomab; Lintuzumab; Lirilumab; Lodelcizumab; Lokivetmab; Lorvotuzumab_mertansine; Lpathomab; Lucatumumab; Lulizumab_pegol; Lumiliximab; Lumretuzumab; Lutetium_(177Lu)_lilotomab_satetraxetan; Margetuximab; Marzeptacog_alfa; Matuzumab; Mavrilimumab; MDX-1303; Mepolizumab; Metelimumab; Milatuzumab; Mirvetuximab; Modotuximab; Mogamulizumab; Monalizumab; Motavizumab; Moxetumomab_pasudotox; Muromonab-CD3; Namilumab; Naptumomab_estafenatox; Narnatumab; Natalizumab; Navicixizumab; Navivumab; Ndimab-varB; Necitumumab; Neliximab; Nemolizumab; Nesvacumab; Neuradiab; Nimotuzumab; Nivolumab; Obiltoxaximab; Obinutuzumab; Ocaratuzumab; Ocrelizumab; Ofatumumab; Olaratumab; Olizuab; Olokizumab; Omalizumab; Onartuzumab; Ontuxizumab; Opicinumab; Oportuzumab_monatox; Oreptacog_alfa; Orticumab; Otelixizumab; Otlertuzumab; Oxelumab; Ozanezumab; Ozoralizumab; Palivizumab; Pamrevlumab; Panitumumab; Pankoab; PankoMab; Panobacumab; Parsatuzumab; Pascolizumab; Pasotuxizumab; Pateclizumab; Patritumab; Pembrolizumab; Perakizumab; Pertuzuab; Pertuzumab; Pexelizumab_h5g1.1-scFv; Pexelizumab; PF-05082566; PF-05082568; Pidilizumab; Pinatuzumab_vedotin; Placulumab; Plozalizumab; Pogalizumab; Polatuzumab_vedotin; Ponezumab; Pritoxaximab; Pritumumab; Quilizumab; Racotumomab; Radretumab; Rafivirumab; Ralpancizumab; Ramucirumab; Ranibizivab; Ranibizumab; Refanezumab; REGN2810; rhuMab_HER2(9CI); rhuMab_HER2; rhuMAb-VEGF; Rilotumumab; Rinucumab; Risankizumab; Rituximab; Rivabazumab_pegol; Robatumumab; Roledumab; Romosozumab; Rontalizuab; Rontalizumab; Rovalpituzumab_tesirine; Rovelizumab; Ruplizumab; Sacituzumab_govitecan; Samalizumab; Sarilumab; Satumomab_pendetide; Secukinumab; Seribantumab; Setoxaximab; Sifalimumab; Siltuximab; Simtuzumab; Sirukumab; Sofituzumab_vedotin; Solanezumab; Solitomab; Sonepcizumab; Stamulumab; Suptavumab; Suvizumab; Tabalumab; Tacatuzuab; Tadocizumab; Talizumab; Tamtuvetmab; Tanezumab; Tarextumab; Tefibazumab; Tenatumomab; Teneliximab; Teplizumab; Teprotumumab; Tesidolumab; Tezepelumab; ThioMAb-chMA79b-HC(A118C); ThioMab-hu10A8.v1-HC(A118C); ThioMab-hu10A8.v1-HC(V205C); ThioMab-hu10A8.v1-LC(A118C); ThioMab-hu10A8.v1-LC(V205C); ThioMAb-huMA79b.v17-HC(A118C); ThioMAb-huMA79b.v18-HC(A118C); ThioMAb-huMA79b.v28-HC(A118C); ThioMAb-huMA79b.v28-LC(V205C); Ticilivab; Tigatuzumab; Tildrakizumab; Tisotumab_vedotin; Tocilizumab; Tosatoxumab; Tositumomab; Tovetumab; Tralokinumab; Trastuzuab; Trastuzumab_emtansine; Trastuzumab; TRC-105; Tregalizumab; Tremelimumab; Trevogrumab; Tucotuzumab_celmoleukin; Ublituximab; Ulocuplumab; Urelumab; Urtoxazumab; Ustekinumab; Vadastuximab_talirine; Vandortuzumab_vedotin; Vantictumab; Vanucizumab; Varlilumab; Vatelizumab; Vedolizumab; Veltuzumab; Vesencumab; Visilizumab; Volociximab; Vorsetuzumab; Vorsetuzumab_mafodotin; Yttrium_(90Y)_clivatuzumab_tetraxetan; Yttrium_Y_90_epratuzumab_tetraxetan; Yttrium_Y_90_epratuzumab; Zalutumumab; Zanolimumab; Zatuximab; Andecaliximab; Aprutumab; Azintuxizumab; Brazikumab; Cabiralizumab; Camrelizumab; Cosfroviximab; Crizanlizumab; Dezamizumab; Duvortuxizumab; Elezanumab; Emapalumab; Eptinezumab; Erenumab; Fremanezumab; Frunevetmab; Gatipotuzumab; Gedivumab; Gemetuzumab; Gilvetmab; Ifabotuzumab; Lacnotuzumab; Larcaviximab; Lendalizumab; Lesofavumab; Letolizumab; Losatuxizumab; Lupartumab; Lutikizumab; Oleclumab; Porgaviximab; Prezalumab; Ranevetmab; Remtolumab; Rosmantuzumab; Rozanolixizumab; Sapelizumab; Selicrelumab; Suvratoxumab; Tavolixizumab; Telisotuzumab; Telisotuzumab_vedotin; Timigutuzumab; Timolumab; Tomuzotuximab; Trastuzumab_duocarmazine; Varisacumab; Vunakizumab; Xentuzumab; anti-rabies_SO57; anti-rabies_SOJB; anti-rabies_SOJA; anti-rabies; anti-RSV_5ITB; anti-alpha-toxin_4U6V; anti-IsdB_5D1Q; anti-IsdB_5D1X; anti-IsdB_5D1Z; anti-HIV_b12; anti-HIV_2G12; anti-HIV_4E10; anti-HIV_VRC01; anti-HIV_PG9; anti-HIV_VRC07; anti-HIV_3BNC117; anti-HIV_10-1074; anti-HIV_PGT121; anti-HIV_PGDM1400; anti-HIV_N6; anti-HIV_10E8; anti-HIV_12A12; anti-HIV_12A21; anti-HIV_35022; anti-HIV_3BC176; anti-HIV_3BNC55; anti-HIV_3BNC60; anti-HIV_447-52D; anti-HIV_5H/I1-BMV-D5; anti-HIV_8ANC195; anti-HIV_CAP256-VRC26.01; anti-HIV_CAP256-VRC26.02; anti-HIV_CAP256-VRC26.03; anti-HIV_CAP256-VRC26.04; anti-HIV_CAP256-VRC26.05; anti-HIV_CAP256-VRC26.06; anti-HIV_CAP256-VRC26.07; anti-HIV_CAP256-VRC26.08; anti-HIV_CAP256-VRC26.09; anti-HIV_CAP256-VRC26.10; anti-HIV_CAP256-VRC26.11; anti-HIV_CAP256-VRC26.12; anti-HIV_CAP256-VRC26.I1; anti-HIV_CAP256-VRC26.I2; anti-HIV_CAP256-VRC26.UCA; anti-HIV_CH01; anti-HIV_CH02; anti-HIV_CH03; anti-HIV_CH04; anti-HIV_CH103; anti-HIV_M66.6; anti-HIV_NIH45-46; anti-HIV_PG16; anti-HIV_PGT122; anti-HIV_PGT123; anti-HIV_PGT125; anti-HIV_PGT126; anti-HIV_PGT127; anti-HIV_PGT128; anti-HIV_PGT130; anti-HIV_PGT131; anti-HIV_PGT135; anti-HIV_PGT136; anti-HIV_PGT137; anti-HIV_PGT141; anti-HIV_PGT142; anti-HIV_PGT143; anti-HIV_PGT144; anti-HIV_PGT145; anti-HIV_PGT151; anti-HIV_PGT152; anti-HIV_VRC-CH30; anti-HIV_VRC-CH31; anti-HIV_VRC-CH32; anti-HIV_VRC-CH33; anti-HIV_VRC-CH34; anti-HIV_VRC-PG04; anti-HIV_VRC-PG04b; anti-HIV_VRC-PG20; anti-HIV_VRC02; anti-HIV_VRC03; anti-HIV_VRC23; anti-HIV_5CCK; anti-HIV_5AWN; anti-HIV_3QEG; anti-HIV_1N0X; anti-HIV_3QEH; anti-HIV_2B1H; anti-HIV_3TNM; anti-HIV_3UJJ; anti-HIV_3UJI; anti-HIV_2QSC; anti-HIV_3MLZ; anti-HIV_3MLX; anti-HIV_3MLW; anti-HIV_3MLV; anti-HIV_3MLU; anti-HIV_3MLT; anti-HIV_3GO1; anti-HIV_4XCY; anti-HIV_4YBL; anti-HIV_4R4N; anti-HIV_4R4B; anti-HIV_3JUY; anti-HIV_4KG5; anti-HIV-1; anti-HIV_V3; anti-HIV_CD4bs; anti-HIV_V2; anti-HIV_C38-VRC18.02; anti-HIV_44-VRC13.02; anti-HIV_45; anti-HIV_cap256-206-252885; anti-HIV_cap256-206-249183; anti-HIV_cap256-206-220956; anti-HIV_cap256-206-220629; anti-HIV_cap256-206-200599; anti-HIV_cap256-206-186347; anti-HIV_cap256-206-186226; anti-HIV_cap256-206-179686; anti-HIV_cap256-206-173707; anti-HIV_cap256-206-173339; anti-HIV_cap256-206-172689; anti-HIV_cap256-206-162744; anti-HIV_cap256-206-146057; anti-HIV_cap256-206-139519; anti-HIV_cap256-206-136316; anti-HIV_cap256-206-116098; anti-HIV_cap256-206-115862; anti-HIV_cap256-206-107018; anti-HIV_cap256-206-098644; anti-HIV_cap256-206-098135; anti-HIV_cap256-206-096276; anti-HIV_cap256-206-092794; anti-HIV_cap256-206-086817; anti-HIV_cap256-206-086446; anti-HIV_cap256-206-086180; anti-HIV_cap256-206-083708; anti-HIV_cap256-206-079556; anti-HIV_cap256-206-078657; anti-HIV_cap256-206-075802; anti-HIV_cap256-206-069097; anti-HIV_cap256-206-067758; anti-HIV_cap256-206-057019; anti-HIV_cap256-206-055385; anti-HIV_cap256-206-053187; anti-HIV_cap256-206-053139; anti-HIV_cap256-206-050350; anti-HIV_cap256-206-046207; anti-HIV_cap256-206-043389; anti-HIV_cap256-206-042555; anti-HIV_cap256-206-029720; anti-HIV_cap256-206-028848; anti-HIV_cap256-206-027652; anti-HIV_cap256-206-024075; anti-HIV_cap256-206-008748; anti-HIV_cap256-206-008530; anti-HIV_cap256-176-723043; anti-HIV_cap256-176-600049; anti-HIV_cap256-176-531926; anti-HIV_cap256-176-504134; anti-HIV_cap256-119-186229; anti-HIV_cap256-119-183891; anti-HIV_cap256-119-183631; anti-HIV_cap256-119-182676; anti-HIV_cap256-119-180772; anti-HIV_cap256-119-180508; anti-HIV_cap256-119-180260; anti-HIV_cap256-119-180173; anti-HIV_cap256-119-179839; anti-HIV_cap256-119-179262; anti-HIV_cap256-119-178995; anti-HIV_cap256-119-178455; anti-HIV_cap256-119-177993; anti-HIV_cap256-119-177727; anti-HIV_cap256-119-176746; anti-HIV_cap256-119-176241; anti-HIV_cap256-119-175215; anti-HIV_cap256-119-173928; anti-HIV_cap256-119-173495; anti-HIV_cap256-119-172882; anti-HIV_cap256-119-172429; anti-HIV_cap256-119-172223; anti-HIV_cap256-119-171838; anti-HIV_cap256-119-171587; anti-HIV_cap256-119-169596; anti-HIV_cap256-119-169523; anti-HIV_cap256-119-169462; anti-HIV_cap256-119-169092; anti-HIV_cap256-119-168680; anti-HIV_cap256-119-166385; anti-HIV_cap256-119-165943; anti-HIV_cap256-119-165738; anti-HIV_cap256-119-164913; anti-HIV_cap256-119-164167; anti-HIV_cap256-119-163558; anti-HIV_cap256-119-162043; anti-HIV_cap256-119-161718; anti-HIV_cap256-119-161675; anti-HIV_cap256-119-161053; anti-HIV_cap256-119-159499; anti-HIV_cap256-119-159114; anti-HIV_cap256-119-156751; anti-HIV_cap256-119-155656; anti-HIV_cap256-119-154420; anti-HIV_cap256-119-153954; anti-HIV_cap256-119-153864; anti-HIV_cap256-119-153793; anti-HIV_cap256-119-153462; anti-HIV_cap256-119-153124; anti-HIV_cap256-119-153025; anti-HIV_cap256-119-152713; anti-HIV_cap256-119-151794; anti-HIV_cap256-119-150980; anti-HIV_cap256-119-148895; anti-HIV_cap256-119-148848; anti-HIV_cap256-119-148743; anti-HIV_cap256-119-148595; anti-HIV_cap256-119-148490; anti-HIV_cap256-119-148470; anti-HIV_cap256-119-148107; anti-HIV_cap256-119-147933; anti-HIV_cap256-119-147434; anti-HIV_cap256-119-146106; anti-HIV_cap256-119-145604; anti-HIV_cap256-119-143998; anti-HIV_cap256-119-143441; anti-HIV_cap256-119-141307; anti-HIV_cap256-119-140896; anti-HIV_cap256-119-140090; anti-HIV_cap256-119-140037; anti-HIV_cap256-119-139135; anti-HIV_cap256-119-137881; anti-HIV_cap256-119-137643; anti-HIV_cap256-119-137170; anti-HIV_cap256-119-136616; anti-HIV_cap256-119-136206; anti-HIV_cap256-119-135565; anti-HIV_cap256-119-135025; anti-HIV_cap256-119-133983; anti-HIV_cap256-119-133917; anti-HIV_cap256-119-132663; anti-HIV_cap256-119-132113; anti-HIV_cap256-119-131839; anti-HIV_cap256-119-130626; anti-HIV_cap256-119-130191; anti-HIV_cap256-119-129798; anti-HIV_cap256-119-128745; anti-HIV_cap256-119-128593; anti-HIV_cap256-119-128152; anti-HIV_cap256-119-127693; anti-HIV_cap256-119-126684; anti-HIV_cap256-119-126056; anti-HIV_cap256-119-125765; anti-HIV_cap256-119-125106; anti-HIV_cap256-119-124026; anti-HIV_cap256-119-121783; anti-HIV_cap256-119-121208; anti-HIV_cap256-119-120945; anti-HIV_cap256-119-118229; anti-HIV_cap256-119-118025; anti-HIV_cap256-119-117418; anti-HIV_cap256-119-117250; anti-HIV_cap256-119-117230; anti-HIV_cap256-119-116999; anti-HIV_cap256-119-116558; anti-HIV_cap256-119-116484; anti-HIV_cap256-119-114844; anti-HIV_cap256-119-114141; anti-HIV_cap256-119-111917; anti-HIV_cap256-119-111862; anti-HIV_cap256-119-110064; anti-HIV_cap256-119-109192; anti-HIV_cap256-119-108793; anti-HIV_cap256-119-108127; anti-HIV_cap256-119-107758; anti-HIV_cap256-119-107209; anti-HIV_cap256-119-107184; anti-HIV_cap256-119-106827; anti-HIV_cap256-119-106511; anti-HIV_cap256-119-106327; anti-HIV_cap256-119-105486; anti-HIV_cap256-119-105197; anti-HIV_cap256-119-104946; anti-HIV_cap256-119-103667; anti-HIV_cap256-119-103385; anti-HIV_cap256-119-103267; anti-HIV_cap256-119-103011; anti-HIV_cap256-119-102072; anti-HIV_cap256-119-101945; anti-HIV_cap256-119-101319; anti-HIV_cap256-119-100871; anti-HIV_cap256-119-100838; anti-HIV_cap256-119-100025; anti-HIV_cap256-119-100000; anti-HIV_cap256-119-098890; anti-HIV_cap256-119-098715; anti-HIV_cap256-119-098632; anti-HIV_cap256-119-097199; anti-HIV_cap256-119-096189; anti-HIV_cap256-119-094581; anti-HIV_cap256-119-094200; anti-HIV_cap256-119-094158; anti-HIV_cap256-119-092814; anti-HIV_cap256-119-092808; anti-HIV_cap256-119-092573; anti-HIV_cap256-119-090815; anti-HIV_cap256-119-090368; anti-HIV_cap256-119-089710; anti-HIV_cap256-119-088555; anti-HIV_cap256-119-087962; anti-HIV_cap256-119-086903; anti-HIV_cap256-119-086804; anti-HIV_cap256-119-085910; anti-HIV_cap256-119-085772; anti-HIV_cap256-119-084603; anti-HIV_cap256-119-084276; anti-HIV_cap256-119-082288; anti-HIV_cap256-119-080383; anti-HIV_cap256-119-079333; anti-HIV_cap256-119-078618; anti-HIV_cap256-119-077466; anti-HIV_cap256-119-076284; anti-HIV_cap256-119-074680; anti-HIV_cap256-119-074081; anti-HIV_cap256-119-071704; anti-HIV_cap256-119-071266; anti-HIV_cap256-119-069667; anti-HIV_cap256-119-069591; anti-HIV_cap256-119-068691; anti-HIV_cap256-119-068488; anti-HIV_cap256-119-067536; anti-HIV_cap256-119-065852; anti-HIV_cap256-119-065457; anti-HIV_cap256-119-064501; anti-HIV_cap256-119-063568; anti-HIV_cap256-119-063103; anti-HIV_cap256-119-061027; anti-HIV_cap256-119-058232; anti-HIV_cap256-119-057341; anti-HIV_cap256-119-056895; anti-HIV_cap256-119-056402; anti-HIV_cap256-119-056034; anti-HIV_cap256-119-055042; anti-HIV_cap256-119-054776; anti-HIV_cap256-119-054539; anti-HIV_cap256-119-054112; anti-HIV_cap256-119-053339; anti-HIV_cap256-119-052404; anti-HIV_cap256-119-051123; anti-HIV_cap256-119-051077; anti-HIV_cap256-119-050442; anti-HIV_cap256-119-049433; anti-HIV_cap256-119-047532; anti-HIV_cap256-119-047489; anti-HIV_cap256-119-046020; anti-HIV_cap256-119-044746; anti-HIV_cap256-119-044740; anti-HIV_cap256-119-043790; anti-HIV_cap256-119-042880; anti-HIV_cap256-119-042606; anti-HIV_cap256-119-042444; anti-HIV_cap256-119-040328; anti-HIV_cap256-119-040164; anti-HIV_cap256-119-039130; anti-HIV_cap256-119-038138; anti-HIV_cap256-119-037868; anti-HIV_cap256-119-037102; anti-HIV_cap256-119-036683; anti-HIV_cap256-119-036495; anti-HIV_cap256-119-035375; anti-HIV_cap256-119-035165; anti-HIV_cap256-119-035109; anti-HIV_cap256-119-033789; anti-HIV_cap256-119-033641; anti-HIV_cap256-119-032113; anti-HIV_cap256-119-031739; anti-HIV_cap256-119-030932; anti-HIV_cap256-119-030740; anti-HIV_cap256-119-030197; anti-HIV_cap256-119-027047; anti-HIV_cap256-119-026950; anti-HIV_cap256-119-026279; anti-HIV_cap256-119-025355; anti-HIV_cap256-119-025301; anti-HIV_cap256-119-025010; anti-HIV_cap256-119-024631; anti-HIV_cap256-119-024467; anti-HIV_cap256-119-023805; anti-HIV_cap256-119-021736; anti-HIV_cap256-119-021203; anti-HIV_cap256-119-020569; anti-HIV_cap256-119-019432; anti-HIV_cap256-119-018827; anti-HIV_cap256-119-018483; anti-HIV_cap256-119-018118; anti-HIV_cap256-119-017782; anti-HIV_cap256-119-017669; anti-HIV_cap256-119-016976; anti-HIV_cap256-119-015432; anti-HIV_cap256-119-015281; anti-HIV_cap256-119-014957; anti-HIV_cap256-119-014777; anti-HIV_cap256-119-014313; anti-HIV_cap256-119-014219; anti-HIV_cap256-119-013631; anti-HIV_cap256-119-012924; anti-HIV_cap256-119-011793; anti-HIV_cap256-119-011413; anti-HIV_cap256-119-011323; anti-HIV_cap256-119-011233; anti-HIV_cap256-119-009038; anti-HIV_cap256-119-008756; anti-HIV_cap256-119-008055; anti-HIV_cap256-119-006949; anti-HIV_cap256-119-006685; anti-HIV_cap256-119-006015; anti-HIV_cap256-119-005841; anti-HIV_cap256-119-005824; anti-HIV_cap256-119-005494; anti-HIV_cap256-119-004949; anti-HIV_cap256-119-004422; anti-HIV_cap256-119-003932; anti-HIV_cap256-119-003577; anti-HIV_cap256-119-002155; anti-HIV_cap256-119-002017; anti-HIV_cap256-119-001312; anti-HIV_cap256-119-001017; anti-HIV_cap256-119-000594; anti-HIV_cap256-059-241099; anti-HIV_cap256-059-207529; anti-HIV_cap256-059-205541; anti-HIV_cap256-059-188439; anti-HIV_cap256-059-187234; anti-HIV_cap256-059-187047; anti-HIV_cap256-059-186068; anti-HIV_cap256-059-182835; anti-HIV_cap256-059-176659; anti-HIV_cap256-059-172956; anti-HIV_cap256-059-171272; anti-HIV_cap256-059-168734; anti-HIV_cap256-059-155838; anti-HIV_cap256-059-149799; anti-HIV_cap256-059-148168; anti-HIV_cap256-059-144685; anti-HIV_cap256-059-140017; anti-HIV_cap256-059-137547; anti-HIV_cap256-059-131908; anti-HIV_cap256-059-116006; anti-HIV_cap256-059-115783; anti-HIV_cap256-059-114609; anti-HIV_cap256-059-113952; anti-HIV_cap256-059-113878; anti-HIV_cap256-059-113622; anti-HIV_cap256-059-109427; anti-HIV_cap256-059-109081; anti-HIV_cap256-059-107590; anti-HIV_cap256-059-107504; anti-HIV_cap256-059-099614; anti-HIV_cap256-059-098972; anti-HIV_cap256-059-097236; anti-HIV_cap256-059-091487; anti-HIV_cap256-059-089812; 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anti-HIV_cap256-048-108152; anti-HIV_cap256-048-107799; anti-HIV_cap256-048-107384; anti-HIV_cap256-048-106530; anti-HIV_cap256-048-106464; anti-HIV_cap256-048-106411; anti-HIV_cap256-048-106306; anti-HIV_cap256-048-104496; anti-HIV_cap256-048-103074; anti-HIV_cap256-048-100832; anti-HIV_cap256-048-100188; anti-HIV_cap256-048-099645; anti-HIV_cap256-048-098137; anti-HIV_cap256-048-097878; anti-HIV_cap256-048-097510; anti-HIV_cap256-048-097313; anti-HIV_cap256-048-096626; anti-HIV_cap256-048-096483; anti-HIV_cap256-048-095691; anti-HIV_cap256-048-095525; anti-HIV_cap256-048-094783; anti-HIV_cap256-048-094356; anti-HIV_cap256-048-090756; anti-HIV_cap256-048-089065; anti-HIV_cap256-048-084986; anti-HIV_cap256-048-083355; anti-HIV_cap256-048-082462; anti-HIV_cap256-048-082246; anti-HIV_cap256-048-080752; anti-HIV_cap256-048-078409; anti-HIV_cap256-048-078273; anti-HIV_cap256-048-078062; anti-HIV_cap256-048-077798; anti-HIV_cap256-048-073853; anti-HIV_cap256-048-071661; anti-HIV_cap256-048-071360; anti-HIV_cap256-048-070955; anti-HIV_cap256-048-070061; anti-HIV_cap256-048-069669; anti-HIV_cap256-048-069205; anti-HIV_cap256-048-068882; anti-HIV_cap256-048-067764; anti-HIV_cap256-048-066845; anti-HIV_cap256-048-065226; anti-HIV_cap256-048-063717; anti-HIV_cap256-048-063150; anti-HIV_cap256-048-062431; anti-HIV_cap256-048-060745; anti-HIV_cap256-048-060420; anti-HIV_cap256-048-060014; anti-HIV_cap256-048-059747; anti-HIV_cap256-048-058393; anti-HIV_cap256-048-058159; anti-HIV_cap256-048-057127; anti-HIV_cap256-048-056251; anti-HIV_cap256-048-055421; anti-HIV_cap256-048-054989; anti-HIV_cap256-048-054759; anti-HIV_cap256-048-052573; anti-HIV_cap256-048-051477; anti-HIV_cap256-048-051299; anti-HIV_cap256-048-050815; anti-HIV_cap256-048-049884; anti-HIV_cap256-048-049170; anti-HIV_cap256-048-048531; anti-HIV_cap256-048-048259; anti-HIV_cap256-048-047313; anti-HIV_cap256-048-046596; anti-HIV_cap256-048-044781; anti-HIV_cap256-048-042599; anti-HIV_cap256-048-041276; anti-HIV_cap256-048-040200; anti-HIV_cap256-048-039061; anti-HIV_cap256-048-038515; anti-HIV_cap256-048-038255; anti-HIV_cap256-048-038177; anti-HIV_cap256-048-035513; anti-HIV_cap256-048-034112; anti-HIV_cap256-048-033983; anti-HIV_cap256-048-032688; anti-HIV_cap256-048-031092; anti-HIV_cap256-048-030464; anti-HIV_cap256-048-030289; anti-HIV_cap256-048-030261; anti-HIV_cap256-048-029362; anti-HIV_cap256-048-027638; anti-HIV_cap256-048-027613; anti-HIV_cap256-048-026627; anti-HIV_cap256-048-026239; anti-HIV_cap256-048-025518; anti-HIV_cap256-048-024854; anti-HIV_cap256-048-024537; anti-HIV_cap256-048-021781; anti-HIV_cap256-048-021758; anti-HIV_cap256-048-020988; anti-HIV_cap256-048-020663; anti-HIV_cap256-048-020590; anti-HIV_cap256-048-019765; anti-HIV_cap256-048-019254; anti-HIV_cap256-048-018073; anti-HIV_cap256-048-016775; anti-HIV_cap256-048-016069; anti-HIV_cap256-048-015867; anti-HIV_cap256-048-015673; anti-HIV_cap256-048-015156; anti-HIV_cap256-048-014521; anti-HIV_cap256-048-014475; anti-HIV_cap256-048-013798; anti-HIV_cap256-048-013271; anti-HIV_cap256-048-013180; anti-HIV_cap256-048-012148; anti-HIV_cap256-048-011870; anti-HIV_cap256-048-011530; anti-HIV_cap256-048-010968; anti-HIV_cap256-048-010224; anti-HIV_cap256-048-009749; anti-HIV_cap256-048-009623; anti-HIV_cap256-048-008234; anti-HIV_cap256-048-008149; anti-HIV_cap256-048-007301; anti-HIV_cap256-048-007174; anti-HIV_cap256-048-007079; anti-HIV_cap256-048-007033; anti-HIV_cap256-048-006128; anti-HIV_cap256-048-005999; anti-HIV_cap256-048-005394; anti-HIV_cap256-048-004226; anti-HIV_cap256-048-004097; anti-HIV_cap256-048-003289; anti-HIV_cap256-048-002601; anti-HIV_cap256-048-002129; anti-HIV_cap256-048-001875; anti-HIV_cap256-048-001302; anti-HIV_cap256-048-001203; anti-HIV_cap256-048-000383; anti-HIV_cap256-038-261791; anti-HIV_cap256-038-241540; anti-HIV_cap256-038-235677; anti-HIV_cap256-038-234314; anti-HIV_cap256-038-234273; anti-HIV_cap256-038-223164; anti-HIV_cap256-038-220289; anti-HIV_cap256-038-220020; anti-HIV_cap256-038-216853; anti-HIV_cap256-038-213466; anti-HIV_cap256-038-213212; anti-HIV_cap256-038-213120; anti-HIV_cap256-038-212592; anti-HIV_cap256-038-211790; anti-HIV_cap256-038-209916; anti-HIV_cap256-038-207938; anti-HIV_cap256-038-202245; anti-HIV_cap256-038-197721; anti-HIV_cap256-038-196679; anti-HIV_cap256-038-196118; anti-HIV_cap256-038-195382; anti-HIV_cap256-038-180001; anti-HIV_cap256-038-178021; anti-HIV_cap256-038-177104; anti-HIV_cap256-038-171261; anti-HIV_cap256-038-169090; anti-HIV_cap256-038-168705; anti-HIV_cap256-038-167685; anti-HIV_cap256-038-158775; anti-HIV_cap256-038-157318; anti-HIV_cap256-038-153058; anti-HIV_cap256-038-150027; anti-HIV_cap256-038-146372; anti-HIV_cap256-038-141868; anti-HIV_cap256-038-141616; anti-HIV_cap256-038-127989; anti-HIV_cap256-038-118109; anti-HIV_cap256-038-112226; anti-HIV_cap256-038-105918; anti-HIV_cap256-038-104487; anti-HIV_cap256-038-102308; anti-HIV_cap256-038-091115; anti-HIV_cap256-038-090262; anti-HIV_cap256-038-083260; anti-HIV_cap256-038-080981; anti-HIV_cap256-038-080873; anti-HIV_cap256-038-074413; anti-HIV_cap256-038-073153; anti-HIV_cap256-038-064227; anti-HIV_cap256-038-061640; anti-HIV_cap256-038-059482; anti-HIV_cap256-038-054000; anti-HIV_cap256-038-050554; anti-HIV_cap256-038-044256; anti-HIV_cap256-038-040944; anti-HIV_cap256-038-040090; anti-HIV_cap256-038-032874; anti-HIV_cap256-038-025899; anti-HIV_cap256-038-024581; anti-HIV_cap256-038-013345; anti-HIV_cap256-038-011559; anti-HIV_cap256-038-009634; anti-HIV_cap256-038-006730; anti-HIV_cap256-038-004887; anti-HIV_cap256-038-004840; anti-HIV_cap256-038-002181; anti-HIV_cap256-038-001902; anti-HIV_cap256-038-000976; anti-HIV_cap256-038-000384; anti-HIV_206-314431; anti-HIV_206-247594; anti-HIV_206-116890; anti-HIV_206-072383; anti-HIV_206-037527; anti-HIV_206-009095; anti-HIV_176-503620; anti-HIV_176-478726; anti-HIV_176-245056; anti-HIV_176-164413; anti-HIV_176-094308; anti-HIV_176-065321; anti-HIV_119-099719; anti-HIV_119-099536; anti-HIV_119-098907; anti-HIV_119-098555; anti-HIV_119-097828; anti-HIV_119-096480; anti-HIV_119-095664; anti-HIV_119-095212; anti-HIV_119-094773; anti-HIV_119-094508; anti-HIV_119-093795; anti-HIV_119-093732; anti-HIV_119-092903; anti-HIV_119-092284; anti-HIV_119-091586; anti-HIV_119-091023; anti-HIV_119-090334; anti-HIV_119-088694; anti-HIV_119-088499; anti-HIV_119-088298; anti-HIV_119-087488; anti-HIV_119-087423; anti-HIV_119-087371; anti-HIV_119-087279; anti-HIV_119-087146; anti-HIV_119-087048; anti-HIV_119-085802; anti-HIV_119-085784; anti-HIV_119-085370; anti-HIV_119-085276; anti-HIV_119-084885; anti-HIV_119-084874; anti-HIV_119-084691; anti-HIV_119-083793; anti-HIV_119-083163; anti-HIV_119-082331; anti-HIV_119-082070; anti-HIV_119-081512; anti-HIV_119-080816; anti-HIV_119-079302; anti-HIV_119-079292; anti-HIV_119-079289; anti-HIV_119-078935; anti-HIV_119-078702; anti-HIV_119-078593; anti-HIV_119-077708; anti-HIV_119-076904; anti-HIV_119-075862; anti-HIV_119-075465; anti-HIV_119-074822; anti-HIV_119-074629; anti-HIV_119-074500; anti-HIV_119-073911; anti-HIV_119-072765; anti-HIV_119-072313; anti-HIV_119-072280; anti-HIV_119-071693; anti-HIV_119-071353; anti-HIV_119-069711; anti-HIV_119-069061; anti-HIV_119-068202; anti-HIV_119-068063; anti-HIV_119-067980; anti-HIV_119-067866; anti-HIV_119-067756; anti-HIV_119-066859; anti-HIV_119-065821; anti-HIV_119-065191; anti-HIV_119-064667; anti-HIV_119-063791; anti-HIV_119-062989; anti-HIV_119-062286; anti-HIV_119-061416; anti-HIV_119-061344; anti-HIV_119-060240; anti-HIV_119-060184; anti-HIV_119-058035; anti-HIV_119-057858; anti-HIV_119-057473; anti-HIV_119-057090; anti-HIV_119-055754; anti-HIV_119-054899; anti-HIV_119-054501; anti-HIV_119-051867; anti-HIV_119-051814; anti-HIV_119-051567; anti-HIV_119-051483; anti-HIV_119-050913; anti-HIV_119-050187; anti-HIV_119-049069; anti-HIV_119-048517; anti-HIV_119-048470; anti-HIV_119-048303; anti-HIV_119-048021; anti-HIV_119-047928; anti-HIV_119-047384; anti-HIV_119-047145; anti-HIV_119-046752; anti-HIV_119-046660; anti-HIV_119-046202; anti-HIV_119-045790; anti-HIV_119-044670; anti-HIV_119-044140; anti-HIV_119-042776; anti-HIV_119-042581; anti-HIV_119-040905; anti-HIV_119-040322; anti-HIV_119-039892; anti-HIV_119-039764; anti-HIV_119-039188; anti-HIV_119-039058; anti-HIV_119-038837; anti-HIV_119-038396; anti-HIV_119-036918; anti-HIV_119-036592; anti-HIV_119-036310; anti-HIV_119-035618; anti-HIV_119-035569; anti-HIV_119-035466; anti-HIV_119-035157; anti-HIV_119-035121; anti-HIV_119-035046; anti-HIV_119-034754; anti-HIV_119-034318; anti-HIV_119-033780; anti-HIV_119-033632; anti-HIV_119-033183; anti-HIV_119-030696; anti-HIV_119-030059; anti-HIV_119-029589; anti-HIV_119-029448; anti-HIV_119-029220; anti-HIV_119-028317; anti-HIV_119-028165; anti-HIV_119-027147; anti-HIV_119-026743; anti-HIV_119-026508; anti-HIV_119-025683; anti-HIV_119-025614; anti-HIV_119-025548; anti-HIV_119-025526; anti-HIV_119-023552; anti-HIV_119-023092; anti-HIV_119-022793; anti-HIV_119-022395; anti-HIV_119-022334; anti-HIV_119-021866; anti-HIV_119-021278; anti-HIV_119-021183; anti-HIV_119-019376; anti-HIV_119-019238; anti-HIV_119-018500; anti-HIV_119-018318; anti-HIV_119-018218; anti-HIV_119-017876; anti-HIV_119-017740; anti-HIV_119-017128; anti-HIV_119-017044; anti-HIV_119-016644; anti-HIV_119-015878; anti-HIV_119-015538; anti-HIV_119-015455; anti-HIV_119-014425; anti-HIV_119-013582; anti-HIV_119-013364; anti-HIV_119-012886; anti-HIV_119-012249; anti-HIV_119-012161; anti-HIV_119-012110; anti-HIV_119-012100; anti-HIV_119-011651; anti-HIV_119-011479; anti-HIV_119-011232; anti-HIV_119-011175; anti-HIV_119-008396; anti-HIV_119-007148; anti-HIV_119-007029; anti-HIV_119-004707; anti-HIV_119-003910; anti-HIV_119-002450; anti-HIV_119-001552; anti-HIV_059-188169; anti-HIV_059-183739; anti-HIV_059-182376; anti-HIV_059-182199; anti-HIV_059-169202; anti-HIV_059-155645; anti-HIV_059-151619; anti-HIV_059-146503; anti-HIV_059-136098; anti-HIV_059-105516; anti-HIV_059-095709; anti-HIV_059-069468; anti-HIV_059-060026; anti-HIV_059-053668; anti-HIV_059-052864; anti-HIV_059-050968; anti-HIV_059-046422; anti-HIV_059-045120; anti-HIV_059-039932; anti-HIV_059-038595; anti-HIV_059-035082; anti-HIV_059-029204; anti-HIV_059-025235; anti-HIV_059-015192; anti-HIV_059-007060; anti-HIV_059-006953; anti-HIV_059-005953; anti-HIV_059-003725; anti-HIV_059-002618; anti-HIV_059-001522; anti-HIV_059-000731; anti-HIV_059-000634; anti-HIV_048-250757; anti-HIV_048-250716; anti-HIV_048-250463; anti-HIV_048-248153; anti-HIV_048-247532; anti-HIV_048-245846; anti-HIV_048-244016; anti-HIV_048-243682; anti-HIV_048-243588; anti-HIV_048-241775; anti-HIV_048-237996; anti-HIV_048-237730; anti-HIV_048-237253; anti-HIV_048-234100; anti-HIV_048-230882; anti-HIV_048-229473; anti-HIV_048-228238; anti-HIV_048-228027; anti-HIV_048-227795; anti-HIV_048-227770; anti-HIV_048-225298; anti-HIV_048-225090; anti-HIV_048-224187; anti-HIV_048-223055; anti-HIV_048-222711; anti-HIV_048-221209; anti-HIV_048-220629; anti-HIV_048-219430; anti-HIV_048-216250; anti-HIV_048-216133; anti-HIV_048-214886; anti-HIV_048-214709; anti-HIV_048-214001; anti-HIV_048-213230; anti-HIV_048-212574; anti-HIV_048-212207; anti-HIV_048-209146; anti-HIV_048-208206; anti-HIV_048-208194; anti-HIV_048-207744; anti-HIV_048-206501; anti-HIV_048-204221; anti-HIV_048-204015; anti-HIV_048-201240; anti-HIV_048-200455; anti-HIV_048-200319; anti-HIV_048-197896; anti-HIV_048-193813; anti-HIV_048-192098; anti-HIV_048-191786; anti-HIV_048-188746; anti-HIV_048-185937; anti-HIV_048-184849; anti-HIV_048-183089; anti-HIV_048-181509; anti-HIV_048-180990; anti-HIV_048-177532; anti-HIV_048-177426; anti-HIV_048-177389; anti-HIV_048-174266; anti-HIV_048-172847; anti-HIV_048-172845; anti-HIV_048-172363; anti-HIV_048-171609; anti-HIV_048-170705; anti-HIV_048-168381; anti-HIV_048-166619; anti-HIV_048-162036; anti-HIV_048-160042; anti-HIV_048-159676; anti-HIV_048-159500; anti-HIV_048-159421; anti-HIV_048-159333; anti-HIV_048-158932; anti-HIV_048-155811; anti-HIV_048-155464; anti-HIV_048-155392; anti-HIV_048-155389; anti-HIV_048-154449; anti-HIV_048-153379; anti-HIV_048-153171; anti-HIV_048-152324; anti-HIV_048-146102; anti-HIV_048-145984; anti-HIV_048-145371; anti-HIV_048-144907; anti-HIV_048-142298; anti-HIV_048-142277; anti-HIV_048-141934; anti-HIV_048-141207; anti-HIV_048-140796; anti-HIV_048-139893; anti-HIV_048-138820; anti-HIV_048-135858; anti-HIV_048-134968; anti-HIV_048-134312; anti-HIV_048-132253; anti-HIV_048-130710; anti-HIV_048-128564; anti-HIV_048-126702; anti-HIV_048-124521; anti-HIV_048-122740; anti-HIV_048-119536; anti-HIV_048-116929; anti-HIV_048-116577; anti-HIV_048-116046; anti-HIV_048-115875; anti-HIV_048-115599; anti-HIV_048-113988; anti-HIV_048-112989; anti-HIV_048-112435; anti-HIV_048-111339; anti-HIV_048-111055; anti-HIV_048-111027; anti-HIV_048-109721; anti-HIV_048-109666; anti-HIV_048-109196; anti-HIV_048-109051; anti-HIV_048-108570; anti-HIV_048-108033; anti-HIV_048-107279; anti-HIV_048-106271; anti-HIV_048-106054; anti-HIV_048-104848; anti-HIV_048-104638; anti-HIV_048-104567; anti-HIV_048-102804; anti-HIV_048-101676; anti-HIV_048-097603; anti-HIV_048-097107; anti-HIV_048-096871; anti-HIV_048-096668; anti-HIV_048-095236; anti-HIV_048-094155; anti-HIV_048-093219; anti-HIV_048-092976; anti-HIV_048-090866; anti-HIV_048-090650; anti-HIV_048-089009; anti-HIV_048-088654; anti-HIV_048-086513; anti-HIV_048-086024; anti-HIV_048-085857; anti-HIV_048-084277; anti-HIV_048-084245; anti-HIV_048-082487; anti-HIV_048-081787; anti-HIV_048-081062; anti-HIV_048-079639; anti-HIV_048-079126; anti-HIV_048-073118; anti-HIV_048-070264; anti-HIV_048-069426; anti-HIV_048-068564; anti-HIV_048-068345; anti-HIV_048-067337; anti-HIV_048-067180; anti-HIV_048-063017; anti-HIV_048-061885; anti-HIV_048-061671; anti-HIV_048-060700; anti-HIV_048-060592; anti-HIV_048-060300; anti-HIV_048-059141; anti-HIV_048-057777; anti-HIV_048-056928; anti-HIV_048-056131; anti-HIV_048-055864; anti-HIV_048-055094; anti-HIV_048-054343; anti-HIV_048-054193; anti-HIV_048-052521; anti-HIV_048-049037; anti-HIV_048-048720; anti-HIV_048-048542; anti-HIV_048-047777; anti-HIV_048-046841; anti-HIV_048-046202; anti-HIV_048-046059; anti-HIV_048-043568; anti-HIV_048-042713; anti-HIV_048-042440; anti-HIV_048-040511; anti-HIV_048-039195; anti-HIV_048-036935; anti-HIV_048-034478; anti-HIV_048-031641; anti-HIV_048-029760; anti-HIV_048-027970; anti-HIV_048-027337; anti-HIV_048-027217; anti-HIV_048-026760; anti-HIV_048-024800; anti-HIV_048-024313; anti-HIV_048-021748; anti-HIV_048-020991; anti-HIV_048-020340; anti-HIV_048-019993; anti-HIV_048-019947; anti-HIV_048-017871; anti-HIV_048-015931; anti-HIV_048-015920; anti-HIV_048-013898; anti-HIV_048-013429; anti-HIV_048-012358; anti-HIV_048-011158; anti-HIV_048-010720; anti-HIV_048-009445; anti-HIV_048-006126; anti-HIV_048-005652; anti-HIV_048-005532; anti-HIV_048-005189; anti-HIV_048-005088; anti-HIV_048-004023; anti-HIV_048-001580; anti-HIV_038-221120; anti-HIV_038-197677; anti-HIV_038-196765; anti-HIV_038-186200; anti-HIV_038-126170; anti-HIV_038-108545; anti-HIV_038-107263; anti-HIV_038-104530; anti-HIV_038-099169; anti-HIV_038-075067; anti-HIV_038-072368; anti-HIV_038-068503; anti-HIV_038-068016; anti-HIV_038-063958; anti-HIV_038-033733; anti-HIV_038-030557; anti-HIV_038-024298; anti-HIV_038-011154; anti-HIV_5CIN; anti-HIV_5CIL; anti-HIV_5CIP; anti-HIV_4JKP; anti-HIV_3TNN; anti-HIV_3BQU; anti-HIV_IgG; anti-HIV_4P9M; anti-HIV_4P9H; anti-HIV_Ig; anti-HIV; anti-influenza; anti-influenza_Apo; anti-influenza-A; anti-OX40; or a fragment or variant thereof.
 24. (canceled)
 25. The RNA according to claim 1, wherein the RNA is monocistronic.
 26. The RNA according to claim 1, wherein the RNA is an mRNA.
 27. (canceled)
 28. The RNA according to claim 1, wherein the G/C content of the at least one coding sequence of the RNA is increased compared to the G/C content of the corresponding coding sequence of the corresponding wild-type RNA, and/or wherein the C content of the at least one coding sequence of the RNA is increased compared to the C content of the corresponding coding sequence of the corresponding wild-type RNA, and/or wherein the codons in the at least one coding sequence of the RNA are adapted to human codon usage, wherein the codon adaptation index (CAI) is preferably increased or maximised in the at least one coding sequence of the RNA, wherein the amino acid sequence encoded by the RNA is preferably not being modified compared to the amino acid sequence encoded by the corresponding wild-type RNA.
 29. The RNA according to claim 1, which comprises a 5′-CAP structure and/or at least one 3′-untranslated region element (3′-UTR element).
 30. The RNA according to claim 1, which comprises at least one histone stem-loop. 31-62. (canceled)
 63. A combination of at least two distinct RNA's according to claim
 1. 64-72. (canceled)
 73. Composition comprising the RNA according to claim 1 and a pharmaceutically acceptable carrier. 74-102. (canceled)
 103. Method of treating or preventing a disorder, wherein the method comprises administering to a subject in need thereof an effective amount of the RNA according to claim
 1. 104. (canceled) 